triolein and Fractures--Bone

Pulmonary haemodynamic and arterial blood gas changes were measured in dogs subjected to either an intravenous injection of triolein or external trauma, which produced fractures of the ipsilateral femur, tibia and fibula. Musculoskeletal trauma resulted in pulmonary vasoconstriction followed by vasodilatation, arterial hypoxia with a pulmonary shunt of 30% and a 20% decrease in systemic oxygen delivery. Lipid injection produced an increased pulmonary vascular resistance, but no significant hypoxia, pulmonary shunting or inadequate tissue oxygenation. We therefore suggest that pulmonary fat embolism does not account for the pulmonary insufficiency following musculoskeletal trauma.

Topics: Animals; Blood Gas Analysis; Dogs; Embolism, Fat; Femoral Fractures; Fibula; Fractures, Bone; Fractures, Closed; Hemodynamics; Muscles; Pulmonary Valve Insufficiency; Respiratory Insufficiency; Tibial Fractures; Triolein

Topics: Animals; Blood Volume; Embolism, Fat; Fibula; Fractures, Bone; Hematoma; Histamine; Injections, Intramuscular; Injections, Subcutaneous; Iodine Isotopes; Lipid Metabolism; Pulmonary Embolism; Rabbits; Tibial Fractures; Triolein

Topics: Animals; Biopsy; Blood Coagulation Tests; Bone and Bones; Collagen; Disease Models, Animal; Disseminated Intravascular Coagulation; Dogs; Embolism, Fat; Exudates and Transudates; Fibrin; Fractures, Bone; Hindlimb; Hypoxia; Leukocytes; Lung; Microscopy; Microscopy, Electron; Muscles; Musculoskeletal System; Pulmonary Edema; Pulmonary Embolism; Triolein

Topics: Adult; Animals; Austria; Biopsy; Blood Volume; Embolism, Fat; Femoral Fractures; Fractures, Bone; Humans; Lung; Male; Pulse; Rabbits; Shock, Traumatic; Triolein

Topics: Animals; Autopsy; Dogs; Embolism, Fat; Fatty Acids, Nonesterified; Fractures, Bone; Humans; Hypoxia; Injections, Intravenous; Intracranial Embolism and Thrombosis; Iodine Isotopes; Lethal Dose 50; Lung; Oleic Acids; Oxygen; Pulmonary Embolism; Rabbits; Triolein