triolein and Amyotrophic-Lateral-Sclerosis

Most of the studies indicate that there is as yet no complete cure for X-ALD. However, methods of the treatment seem to slow rather than treat the disease. One method is the use of Lorenzo's oil in conjunction with a low fat diet, which may help in cerebral X-ALD. X-ALD is in very close resemblance to another neurodegenerative disease, amyotrophic lateral sclerosis (ALS). One of the believed pathomechanisms of ALS is oxidative stress; therefore, this article's emphasis on the role of reactive oxygen species in X-ALD. The aim of the present study was to review the literature concerning the advances in the treatment of X-adrenoleukodystrophy (X-ALD, OMIM # 300100) in the last two decades and to shed more light on the link between oxidative stress and X-ALD. This review article may point to a deficit in reactive oxygen species (ROS) scavenging and/or ROS overproduction being involved in the aetiopathology of these neurodegenerative diseases. Consequently, one of the useful neuronal rescue strategies could be the treatment with antioxidant agents.

Topics: Adrenoleukodystrophy; Amyotrophic Lateral Sclerosis; Animals; Antioxidants; Drug Combinations; Erucic Acids; Free Radical Scavengers; Humans; Oxidative Stress; Reactive Oxygen Species; Triolein

Topics: Aged; Amyotrophic Lateral Sclerosis; Female; Glucose Tolerance Test; Humans; Injections, Intravenous; Iodine Radioisotopes; Leucyl Aminopeptidase; Male; Middle Aged; Oleic Acids; Pancreas; Secretin; Tolbutamide; Triolein

Topics: Adult; Amylases; Amyotrophic Lateral Sclerosis; Glucose Tolerance Test; Humans; Iodine Radioisotopes; Male; Middle Aged; Neostigmine; Triolein