trinitrobenzenesulfonic acid has been researched along with Disease Models, Animal in 910 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (0.44) | 18.7374 |
| 1990's | 72 (7.91) | 18.2507 |
| 2000's | 281 (30.88) | 29.6817 |
| 2010's | 457 (50.22) | 24.3611 |
| 2020's | 96 (10.55) | 2.80 |
| Authors | Studies |
|---|---|
| Fichna, J; Jacenik, D; Krajewska, WM; Małecka-Panas, E; Mokrowiecka, A; Salaga, M; Zatorski, H; Zielińska, M | 1 |
| Chen, M; Chen, Z; Li, X; Mao, R; Miao, X; Qiu, C; Ren, J; Wang, P; Yin, T; You, Y; Zheng, R; Zhou, H | 1 |
| Aziz, M; Bôle-Feysot, C; Dupont-Lucas, C; Goichon, A; Guerin, C; Marion-Letellier, R; Nicol, L; Pala, M; Salameh, E; Savoye, G; Savoye-Collet, C | 1 |
| Chávez, MN; Das, S; Diaz, OE; Frede, A; Krais, AM; Luo, X; Morales, RA; Sorini, C; Villablanca, EJ; Wincent, E | 1 |
| Wang, J; Zheng, Z | 1 |
| Chen, H; Chen, Z; Gong, D; Li, H; Li, J; Li, Y; Ma, R; Ren, M; Wang, J; Xie, Q | 1 |
| Chen, C; Chen, L; Liu, W; Liu, Y; Ma, X; Wang, J; Wang, X; Xiang, Z; Xu, B | 1 |
| Alotaibi, NM; Murad, HA; Shaikh-Omar, A | 1 |
| Bettadaiah, BK; Mathew, NS; Muthukumar, SP; Negi, PS | 1 |
| Geesala, R; Lin, YM; Qiu, S; Shi, XZ; Zhang, K | 1 |
| Burukoğlu Dönmez, D; Can, B; Kanbak, G; Özkoç, M; Şentürk, H | 1 |
| Chen, T; Kuang, X; Li, Z; Shen, T; Wu, J | 1 |
| Mateus, V; Pinto, R; Silva, I; Solas, J | 1 |
| Ibrahim, HIM; Khalifa, A; Sheikh, A | 1 |
| Li, X; Liu, Z; Peng, Y; Zhao, L | 1 |
| Chen, L; Chen, LL; Chen, YP; Chu, KD; Fan, LM; Liu, YJ; Wang, Y; Xu, W; Xu, WH; Zhang, JP; Zhang, YQ | 1 |
| Abdollahi, A; Chaboki, A; Dehpour, AR; Hamaneh, AM; Mohammadi, S; Rashidian, A; Shayan, M; Sheibani, M; Yousefi-Manesh, H | 1 |
| Boirivant, M; Butera, A; Campanile, D; Crippa, L; Di Carlo, N; Labbaye, C; Quaranta, MT; Saulle, E; Spinello, I | 1 |
| Liu, H; Sun, MZ; Xiao, H; Zhang, C; Zhang, HC; Zhang, JN; Zhao, HR; Zhao, Y | 1 |
| Guerra, S; Mateus, V; Mendes, P; Pinto, R; Silva, I | 1 |
| Horsnell, W; Katsandegwaza, B; Smith, K | 1 |
| Chen, QQ; Deng, F; Li, DW; Li, J; Li, Y; Ling Hu, EQ; Wan, J; Zhu, WY | 1 |
| Chen, W; Chen, X; He, F; He, Y; Li, L; Lin, H; Liu, Q; Lu, J; Ni, B; Xu, R; Yang, F; Zhang, Q; Zheng, X; Zhong, X; Zou, X | 1 |
| Cao, YN; Liu, KC; Sun, M; Tu, PF; Wang, XX; Zhang, XM; Zhang, Y; Zou, HY | 1 |
| Wu, S; Xie, Y; Xiong, H; Xue, G; Zhang, Y; Zhao, Q; Zhao, R; Zhou, N | 1 |
| Chudan, S; Furusawa, Y; Ikushiro, S; Ishibashi, R; Nagai, Y; Nishikawa, M; Tabuchi, Y | 1 |
| Chen, C; Liu, M; Liu, W; Liu, X; Liu, Y; Wang, J; Wang, X; Wang, Z; Xiang, Z; Xiao, H; Yue, D | 1 |
| Bartolí, R; Bernal, C; Domènech, E; Garcia, A; Garcia-Jaraquemada, A; Jou-Ollé, E; Llaves, M; Lorén, V; Mañosa, M; Manyé, J; Pertegaz, A; Schiering, K; Suau, R; Vergara, P | 1 |
| Chen, Y; Fan, T; Li, J; Tian, Z; Wang, X; Wu, J; Zhuang, X | 1 |
| Fu, Y; Gu, M; He, Y; Li, R; Lin, S; Pan, Y; Sheng, J; Tao, Y; Wang, J; Wang, Z; Wei, P; Wu, Z; Xie, H; Xu, J; Zhang, C | 1 |
| Edelblum, KL; Kuo, WT; Nilsen, SP; Ong, MLDM; Shashikanth, N; Shen, L; Turner, JR; Wang, Y; Wu, L; Zha, J; Zuo, L | 1 |
| Castro-Ochoa, KF; Citalán-Madrid, AF; Schnoor, M; Vargas-Robles, H | 1 |
| Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D | 1 |
| Calabresi, MFF; Di Stasi, LC; Mello, FPF; Miranda, JRA; Próspero, AG; Soares, G; Tanimoto, A | 1 |
| Alvarenga, V; Baetas da Cruz, W; Bernardazzi, C; Bonfá, ND; Castelo-Branco, MT; de Souza, HSP; Madi, K; Nanini, H; Pêgo, B; Schanaider, A; Silva, PTD | 1 |
| Brierley, SM; Daly, DM; Garcia-Caraballo, S; Grundy, D; Grundy, L; Konthapakdee, N; O'Donnell, T | 1 |
| Bao, CH; Jin, XM; Li, GN; Liu, HR; Shi, Z; Wang, CY; Wang, D; Wang, XM; Wu, HG; Wu, LY; Yan, YL | 1 |
| Brierley, SM; Bunnett, NW; Castro, J; Chang, L; Dong, X; Garcia-Caraballo, S; Ghetti, A; Grundy, L; Harrington, AM; Lieu, T; Lumsden, AL; Maddern, J; Miller, P; O'Donnell, T; Poole, DP; Schober, G; Steinhoff, MS | 1 |
| Alam, MM; Huang, Y; Mathur, R; Zhao, XF; Zhu, X | 1 |
| Cui, X; Li, GQ; Liu, Y; Wang, XH; Xu, LQ; Yang, WR; Zhao, Q; Zuo, XL | 1 |
| Dziendzikowska, K; Gajewska, M; Gromadzka-Ostrowska, J; Harasym, J; Wilczak, J; Żyła, E | 1 |
| Jang, SE; Min, SW | 1 |
| Çeribaşı, AO; Cevik, CK; Gökbulut, A; Süntar, I | 1 |
| Bai, Y; Chen, T; Chen, YB; Fan, BY; Li, H; Li, YQ; Ma, LT; Qiu, XT; Sun, HK; Zhang, MM; Zhang, T | 1 |
| He, X; Hu, T; Lan, P; Liang, Z; Liu, H; Wang, F; Wu, X; Zheng, X; Zhou, C | 1 |
| Khan, I; Khan, K | 1 |
| Chun, H; Jones-Hall, YL; Kozik, AJ; Nakatsu, CH | 2 |
| Cazals-Hatem, D; Collard, M; Doblas, S; Flacs, M; Maggiori, L; Ogier-Denis, E; Panis, Y; Treton, X; Zappa, M | 1 |
| Chen, M; Li, J; Liu, L; Zhao, Q | 1 |
| Chen, QQ; Chen, Z; Du, HT; Li, Y; Wan, J; Yuan, J | 1 |
| Chen, L; Geng, H; Pei, LX; Song, YF; Sun, JH; Wu, J; Xu, WL; Yuan, MQ; Zhou, JY | 1 |
| Jia, K; Tong, X; Wang, R; Wang, Y | 1 |
| Allahverdi, A; Asadi, F; Ebrahimi-Barough, S; Heidari Barchi Nezhad, R; Khajouee Ravari, S; Lotfibakhshaiesh, N; Mirzaei, MR; Mirzahosseini-Pourranjbar, A; Niknia, S; Tashakori, M; Yousefi-Ahmadipour, A | 1 |
| Albuquerque, RM; Araújo E Silva, AC; Dittz, D; Ferreira, Ê; Freitas, KM; Lopes, MTP; Pizzitola, MP; Salas, CE | 1 |
| Lu, Y; Sun, Y; Wu, L; Xu, J; Yu, P | 1 |
| Li, N; Shi, RH | 1 |
| Bai, G; Bai, XS; Huan, Y; Li, Y; Tang, LD; Wang, H | 1 |
| Alard, J; Blanc, P; Boulard, O; Boutillier, D; Cesaro, A; Chamaillard, M; Couturier-Maillard, A; Delacre, M; Grangette, C; Hrdý, J; Lapadatescu, C; Pot, B; Ryffel, B | 1 |
| Gao, R; Guo, L; Li, D; Luo, M; Wang, J; Wang, L; Wei, C; Wu, B; Xiong, F; Xu, Z; Yao, J; Yu, Z; Zhang, D | 1 |
| Cui, J; Gao, J; Guo, W; Jiang, C; Jiao, C; Li, Y; Liu, W; Xu, Q; Zhong, H | 1 |
| Shen, H; Shen, ZF; Xu, LZ; Zhan, LB; Zhao, S; Zhu, L | 1 |
| Al Ojaimi, Y; Bahr, GM; Bazzi, S; Echtay, KS; Khachab, M | 1 |
| Dong, W; Huang, F; Mei, Y; Wang, J; Wu, J; Zhang, T | 1 |
| Indah Widasari, D; Putri Umizah, L; Setyo, P; Wasityastuti, W | 1 |
| Almási, N; Baráth, Z; Csonka, Á; Dvorácskó, S; Kupai, K; Murlasits, Z; Pósa, A; Tömböly, C; Török, S; Valkusz, Z; Varga, C | 1 |
| Huang, G; Li, S; Tang, X; Zhang, T | 1 |
| Chen, JDZ; Gharibani, P; Tu, L; Yin, J | 1 |
| Alcudia, A; Argüelles-Arias, F; De-Miguel, M; García-Montes, JM; Illanes, M; Macías-García, L; Motilva, V; Ortiz, T; Talero, E; Vázquez-Román, V | 1 |
| Chen, Z; Guan, Y; Kang, J; Liu, H; Yang, M; Yang, S; Zhao, T; Zhou, L | 1 |
| Bai, X; Ding, J; Guo, H; Jin, X; Liu, M; Liu, X; Pang, J; Yang, Y; Zhang, L; Zhang, Y | 1 |
| Ke, X; Ma, Z; Shi, Y; Xuan, L; Zhu, Y | 1 |
| Abiodun, OO; Nwadike, N; Oshinloye, AO; Sosanya, AS | 1 |
| Bálint, B; Balogh, P; Boros, É; Kellermayer, Z; Maróti, Z; Nagy, I; Prontvai, B; Sarlós, P; Varga, C; Vincze, Á | 1 |
| Biagioli, M; Bordoni, M; Carino, A; Di Giorgio, C; Distrutti, E; Fiorucci, S; Marchianò, S; Roselli, R | 1 |
| Cao, X; Chen, S; Duan, L; Guo, Z; Han, Z; Han, ZC; Hou, H; Li, Z; Liu, N; Liu, Y; Qi, X; Wang, C; Zhang, D; Zhang, S; Zhao, Q | 1 |
| Alves Júnior, EB; Araújo, AA; Batista, LM; de Araújo Júnior, RF; de Jesus, NZT; Formiga, RO; Lima, GRM; Machado, FDF; Marinho, AF; Pellizzon, CH; Santos, FA; Tavares, JF; Viana, AFSC | 1 |
| Allais, L; Bachert, C; Bracke, KR; Brusselle, GG; Cuvelier, CA; De Smet, R; De Vos, M; Devriese, S; Gonzales, GB; Laukens, D; Maes, T; Peeters, H; Van Crombruggen, K; Verschuere, S | 1 |
| Hubens, G; Pype, C; Timmermans, JP; Uyttebroek, L; Van Nassauw, L | 1 |
| Sharma, S; Sinha, VR | 1 |
| Cao, X; Chen, S; Duan, L; Guo, Z; Han, Z; Han, ZC; Huang, H; Li, Z; Wang, C; Zhao, X; Zhou, M | 1 |
| Assohoun, ALW; Boudebbouze, S; Boutillier, D; Cuffaro, B; Desramaut, J; Grangette, C; Hrdý, J; Maguin, E; Salomé-Desnoulez, S; Súkeníková, L; Waligora-Dupriet, AJ | 1 |
| Feng, W; Gu, P; Jia, J; Lu, Y; Shen, H; Xu, Y; Yan, S; Yu, J; Zheng, K; Zhu, L; Zhu, P | 1 |
| Brzozowski, T; Dieterich, W; Konturek, K; Konturek, PC; Krzysiek-Maczka, G; Kwiecien, S; Magierowska, K; Magierowski, M; Neurath, M; Ptak-Belowska, A; Sliwowski, Z; Strzalka, M; Szczyrk, U; Targosz, A; Wirtz, S; Wojcik, D; Zopf, Y | 1 |
| Liang, Y; Luo, S; Nong, F; Wen, B; Xing, S; Zhao, Z; Zhou, L | 1 |
| Almeida, POA; Arunachalam, K; Cruz, TCDD; Damazo, AS; Figueiredo, FF; Martins, DTO; Oliveira, DM; Pavan, E; Silva, JVD; Venturini, CL | 1 |
| da Cunha, VP; Machado, DCC; Miyoshi, A; Pereira, VB; Preisser, TM; Santana, MP | 1 |
| Amamou, A; Aziz, M; Bôle-Feysot, C; Colasse, E; David, A; Dupont-Lucas, C; Guerin, C; Jarbeau, M; Marion-Letellier, R; Nicol, L; Pala, M; Savoye, G; Savoye-Collet, C | 1 |
| Chen, G; Diao, F; Dong, M; Li, Y; Lin, W; Liu, T; Liu, Y; Mei, Q; Ruan, Y; Sun, Y; Tang, T; Zhou, H | 1 |
| Antonielli, LF; Arunachalam, K; Damazo, AS; Duckworth, CA; Lima, JCDS; Martins, DTO; Miyajima, F; Oliveira, RG; Pavan, E | 1 |
| Cao, Z; Cheng, Y; Cui, L; Li, Y; Ma, C; Wang, N; Wang, Q; Wang, Y; Wu, X; Zhang, B | 1 |
| Bruce, J; Goggins, BJ; Horvat, JC; Keely, S; Knight, D; Liu, G; Mathe, A; Minahan, K; Pryor, J; Sherwin, S; Soh, WS; Walker, MM | 1 |
| Du, YL; He, J; Huang, HL; Li, YF; Nie, YQ; Xu, HM; Xu, J; Zhao, C; Zhou, YJ; Zhou, YL | 1 |
| Brumovsky, PR; Chi, L; Emadi, S; Feng, B; Guo, T; Han, M; Patel, S; Pierce, DM; Shah, D | 1 |
| Guo, D; Han, Z; Wang, H; Zhang, J | 1 |
| Capas-Peneda, S; Dias-Pereira, P; Duarte-Araújo, M; Esteves-Monteiro, M; Ferreira-Duarte, M; Gonçalves-Monteiro, S; Magro, F; Menezes-Pinto, D; Morato, M; Rodrigues-Pinto, T | 1 |
| Chattopadhyay, N; Mehta, P; Mittal, M; Rajender, S; Rajput, S | 1 |
| Chiu, CY; Helge Schebb, N; Huang, D; Kühn, H; Rohwer, N; Rothe, M; Rund, KM; Smyl, C; Weylandt, KH | 1 |
| Gou, W; Lancaster, WP; Morgan, KA; Swaby, L; Wang, H; Wolfe, AM | 1 |
| Aragón, E; Delgado, M; Escolà, A; Farrera-Sinfreu, J; Fernández-Carneado, J; Gonzalez-Rey, E; Macias, MJ; Martin-Malpartida, P; Ponsati, B; Puig, E; Riera, A; Rol, Á; Todorovski, T; Vallès-Miret, M; Verdaguer, X | 1 |
| Ala, M; Dehpour, AR; Hashemian, SM; Mohammad Jafari, R; Rashidian, A; Shayesteh, S; Sorouri, M; Yousefi-Manesh, H | 1 |
| Jiang, Y; Jin, Q; Kuang, Y; Liu, K; Long, D; Qian, K; Wang, S; Yao, H; Yuan, L; Zhao, H | 1 |
| Chen, J; Fu, Y; Huang, Z; Ma, G; Shi, T; Wang, W; Zhang, J; Zhang, Y; Zhu, J | 1 |
| Chen, L; Guo, Y; Li, X; Pu, Y; Shen, Y; Shi, M; Wang, B; Wang, W; Wang, Z; Xu, C; Yang, J; Zhang, L; Zhang, T | 1 |
| Chandra, J; Dejanovic, D; Li, J; McDonald, C; Rieder, F; Zangara, MT | 1 |
| Clark, RJ; Cristofori-Armstrong, B; Haigh, OL; Loukas, A; Lutzky, VP; Miles, JJ; Mulvenna, JP; Navarro, S; Rosengren, KJ; Ryan, RYM; Smallwood, TB; Tungatt, K; Watkins, TS | 1 |
| Huang, M; Jiang, W; Luo, C; Ren, Y; Zhang, X | 1 |
| Ling-Fen, X; Tian-Chu, H; Yin, B | 1 |
| Chen, L; Chen, RY; Fan, JH; Gu, GL; Jiang, HX; Jin, H; Li, SQ; Liang, ZL; Liu, GF; Lu, F; Lv, XD; Lv, XP; Qin, LF; Wang, HQ; Xie, YF; Zhan, LL | 1 |
| Amamou, A; Aziz, M; Goichon, A; Guérin, C; Marion-Letellier, R; Rouland, M; Savoye, G; Yaker, L | 1 |
| Bartoszek, A; Binienda, A; Dziedziczak, K; Fabisiak, A; Fichna, J; Kordek, R; Krajewska, JB; Mosińska, P; Niewinna, K; Salaga, M; Talar, M; Tarasiuk, A | 1 |
| Chen, J; Duan, L; Shi, G; Tao, Y; Tu, L; Xie, Z; Xu, D; Yu, B | 1 |
| Kaneko, Y; Kato, K; Kojo, Y; Onoue, S; Sato, H; Seto, Y; Suzuki, H; Tsukada, R | 1 |
| Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G | 1 |
| Blennerhassett, MG; Ghasemlou, N; Lourenssen, SR; Parlow, LRG; Winterborn, AN | 1 |
| Ni, R; Qian, J; Tang, Q; Wang, L; Wu, H; Yan, L; Zhang, D; Zou, X | 1 |
| Dai, X; Gui, G; Li, K; Liu, J; Xiao, Y; Yang, H | 1 |
| Chen, L; Luo, D; Yu, B | 1 |
| Al-Jarallah, A; Oriowo, M | 1 |
| Castelucci, P; da Silva, MV; Marosti, AR; Mendes, CE; Palombit, K | 1 |
| Cai, Y; Chen, S; Du, C; Gao, Y; Lai, W; Qin, C; Yang, C; Zhou, J | 1 |
| Babygirija, R; Kannampalli, P; Miranda, A; Sengupta, JN; Sood, M | 1 |
| Chiu, CT; Hung, SW; Kuo, SN; Yang, CY | 1 |
| Arijs, I; Arnold, B; Breynaert, C; de Bruyn, M; De Hertogh, G; Ferrante, M; Geboes, K; Hu, J; Matteoli, G; Opdenakker, G; Thijs, G; Van Assche, G; Van Damme, J; Vermeire, S | 1 |
| Fichtner-Feigl, S; Gerlach, K; Kindermann, M; Neurath, MF; Popp, V; Weigmann, B; Wirtz, S | 1 |
| Afroz, S; Khan, RA; Mallick, N; Riaz, A | 1 |
| Han, MJ; Jang, HM; Jang, SE; Jeong, JJ; Kim, DH; Lee, HJ; Lim, SM | 1 |
| Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB | 1 |
| Chen, R; Chen, X; Dong, X; Huang, X; Huang, Z; Jiang, X; Lin, H; Lin, X; Wu, X; Yang, X | 1 |
| Hua, Z; Xu, L; Yang, Y; Zhang, M; Zhang, S; Zhou, L; Zou, X | 1 |
| Brichta, AM; Callister, RJ; Farrell, KE; Graham, BA; Keely, S; Walker, MM | 1 |
| Chen, R; Huang, X; Huang, Z; Jiang, X; Lin, H; Zhang, W | 1 |
| Endharti, AT; Permana, S | 1 |
| Andrews, C; Anver, MR; Baseler, WA; Davies, LC; Durum, SK; Hanson, ML; Hixon, J; Li, W; McLean, MH; Senkevitch, E; Shen, W; Smith, C; Staniszewska, AK; Steidler, L | 1 |
| Golomb, B; Griffey, S; Heeney, D; Marco, M; Srisengfa, Y; Yin, X | 1 |
| Augui, S; Boisgard, R; Braun, E; Bréchot, C; Chiappini, F; Darnaud, M; De Hertogh, G; Desterke, C; Doré, J; Dos Santos, A; Dubuquoy, L; Faivre, J; Gonzalez, P; Guerrieri, F; Lacoste, C; Lepage, P; Moniaux, N; Neut, C; Samuel, D; Valentino, E; Zheng, J | 1 |
| Suolang, Y; Tang, Y; Zhang, Y; Zhao, L; Zhou, D | 1 |
| Kuzmanov, A; Kuzmanova, V; Tzaneva, M; Valcheva-Kuzmanova, S | 1 |
| Fricker, M; Gellatly, SL; Goggins, BJ; Hansbro, PM; Jarnicki, AG; Jones, B; Keely, S; Kim, RY; Mateer, S; Oliver, BG; Powell, N; Radford-Smith, G; Talley, NJ; Walker, MM | 1 |
| Cheng, YY; Guo, Y; Ma, L; Qiao, L; Xu, CL | 1 |
| Alard, J; Boutillier, D; Breton, J; Grangette, C; Holowacz, S; Kuylle, S; Peucelle, V; Pot, B | 1 |
| Li, Q; Liu, L; Noë, M; Pasricha, PJ; Zhu, Y | 1 |
| Ahemaiti, A; Aximujiang, K; Huang, J; Wu, G; Xu, C; Yunusi, K; Zhang, J; Zhong, L | 1 |
| Cao, DL; Han, Y; Lu, Y; Zhang, YL; Zhao, LX | 1 |
| Li, L; Long, Y; Shen, Y; Xie, Y; Zeng, Y; Zhao, Y | 1 |
| Chopade, SS; Dhaneshwar, SS | 1 |
| Barbosa, ALDR; da Silva Martins, C; de Aguiar Magalhãres, D; de Brito, TV; de Sousa de Almeida Leite, JR; Fernando Pereira Vasconcelos, D; Guimarães Sousa, S; José Dias Júnior, G; Maria Costa Véras, L; Oliveira Silva, R; Rodolfo Pereira da Silva, F; Rodrigues de Carvalho, L; Santos Martins, D; Simião da C Júnior, J; Soares de Oliveira, J | 1 |
| Berindan-Neagoe, I; Catana, CS; Cozma, V; Crăciun, EC; Deak, G; Dumitraşcu, DL; Gherman, CM; Magdas, C; Magdaş, VA; Tabaran, FA | 1 |
| Bevivino, G; Colantoni, A; De Simone, V; Di Giovangiulio, M; Franzè, E; Izzo, R; Marafini, I; Monteleone, G; Monteleone, I; Ortenzi, A; Rizzo, A; Sedda, S | 1 |
| Cai, Y; Dong, Z; Du, C; Gao, Y; Lai, W; Ma, N; Pan, J; Shen, H; Xie, X; Yang, C; Yang, W; Zhang, R; Zhang, Y; Zhou, J | 1 |
| Hashimoto, N; Kaneko, Y; Kato, K; Kojo, Y; Onoue, S; Sato, H; Seto, Y; Suzuki, H; Yuminoki, K | 1 |
| He, X; Huang, Q; Ke, J; Lan, P; Lian, L; Qin, H; Xie, M; Zhang, L | 1 |
| Bernstein, CN; Guan, Q; Peng, Z; Qing, G; Wang, S; Warrington, RJ; Weiss, CR; Yang, X | 1 |
| Ceranowicz, P; Chmura, A; Cieszkowski, J; Dembiński, A; Gałązka, K; Konarska, K; Konturek, TJ; Kowalczyk, P; Kuśnierz-Cabala, B; Miskiewicz, A; Pędziwiatr, M; Warzecha, Z | 1 |
| Basbaum, A; Bosmans, F; Braz, J; Brierley, SM; Castro, J; Deiteren, A; Erickson, A; Gilchrist, J; Grundy, L; King, GF; Li, Q; Pasricha, PJ; Rais, R; Rychkov, GY; Salvatierra, J; Slusher, BS | 1 |
| Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Magar, TBT; Shrestha, A | 1 |
| E Silva, FGD; Netto, FM; Paiatto, LN; Simioni, PU; Tamashiro, WMSC; Yamada, AT | 1 |
| Bueren, JA; Dalemans, W; Delarosa, O; Escolano, A; Garin, MI; Lombardo, E; Lopez-Santalla, M; Mancheño-Corvo, P; Menta, R; Redondo, JM | 1 |
| Dou, J; Fan, H; Fang, K; Gu, Y; Mao, K; Wang, H; Wang, Y; Zhou, C | 1 |
| Liu, M; Lu, Y; Wu, L; Xu, J; Yu, P | 3 |
| Qian, H; Zhou, H | 1 |
| Alhouayek, M; Bottemanne, P; Masquelier, J; Muccioli, GG; Paquot, A; Terrasi, R | 1 |
| Hiraishi, K; Hu, YP; Inoue, R; Jian, YW; Koga, K; Kojima, D; Kurahara, LH; Onitsuka, M; Sumiyoshi, M; Takedatsu, H; Yue, L | 1 |
| Beck, SE; Chan, GV; Chan, JL; Chung, L; Ding, H; Fan, H; Geis, AL; Gomes, TAM; Housseau, F; Pardoll, DM; Sears, CL; Tam, AJ; Wang, H; Wu, S; Wu, X | 1 |
| Brierley, SM; Castro, J; Deiteren, A; Feil, R; Garcia-Caraballo, S; Ge, P; Ghetti, A; Grundy, L; Hannig, G; Harrington, AM; Kurtz, CB; Maddern, J; Miller, P; Peters, S; Rychkov, GY; Silos-Santiago, I | 1 |
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14 review(s) available for trinitrobenzenesulfonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2022 |
Beneficial effects of nutritional supplements on intestinal epithelial barrier functions in experimental colitis models
Topics: Animals; Caco-2 Cells; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Drug Evaluation, Preclinical; Fatty Acids; Humans; Intestinal Absorption; Intestinal Mucosa; Oxidative Stress; Permeability; Phytochemicals; Tight Junctions; Treatment Outcome; Trinitrobenzenesulfonic Acid; Vitamins | 2019 |
Human Relevance of Preclinical Studies on the Skeletal Impact of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Topics: Animals; Bone Diseases, Metabolic; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Trinitrobenzenesulfonic Acid | 2021 |
Quality of methods reporting in animal models of colitis.
Topics: Animals; Checklist; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-10; Leukocyte Common Antigens; Research Design; Trinitrobenzenesulfonic Acid | 2015 |
Toward a better understanding of the central consequences of intestinal inflammation.
Topics: Animals; Colitis, Ulcerative; Colon; Crohn Disease; Disease Models, Animal; Humans; Inflammation; Rats; Receptors, AMPA; Trinitrobenzenesulfonic Acid | 2015 |
The Role of Neuropeptides in Mouse Models of Colitis.
Topics: Animals; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Gene Deletion; Intestinal Mucosa; Mice; Neuropeptides; Trinitrobenzenesulfonic Acid | 2016 |
Lessons from probiotic-host interaction studies in murine models of experimental colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-10; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Probiotics; Trinitrobenzenesulfonic Acid | 2011 |
Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (TNBS) rat model of inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arginine; Blotting, Western; Colitis; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inflammatory Bowel Diseases; Injections, Subcutaneous; Instillation, Drug; Male; Models, Animal; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2003 |
[Real time PCR: principle and usage].
Topics: Animals; Colitis; Computer Systems; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Intestinal Mucosa; Polymerase Chain Reaction; Rats; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2004 |
Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Immune Tolerance; Immunity, Mucosal; Inflammation; Mice; Mouth Mucosa; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2004 |
Critical appraisal of the current practice in murine TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Hypersensitivity; Gene Expression Profiling; Health Planning Guidelines; Humans; Hypersensitivity, Delayed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 2006 |
Importance of CD44 variant isoforms in mouse models for inflammatory bowel disease.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Genetic Variation; Humans; Hyaluronan Receptors; Inflammatory Bowel Diseases; Mice; Th1 Cells; Trinitrobenzenesulfonic Acid | 1999 |
TNBS-colitis.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Humans; Trinitrobenzenesulfonic Acid | 2000 |
Modulation of heme oxygenase in tissue injury and its implication in protection against gastrointestinal diseases.
Topics: Animals; Brain Injuries; Colon; Cytoprotection; Disease Models, Animal; Enzyme Induction; Gastrointestinal Diseases; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Inflammation; Kidney; Liver; Male; Membrane Proteins; Rats; Reperfusion Injury; Trinitrobenzenesulfonic Acid; Wounds and Injuries | 2001 |
4 trial(s) available for trinitrobenzenesulfonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Linaclotide inhibits colonic nociceptors and relieves abdominal pain via guanylate cyclase-C and extracellular cyclic guanosine 3',5'-monophosphate.
Topics: Abdominal Pain; Adult; Aged; Aged, 80 and over; Animals; Caco-2 Cells; Cell Line; Colon; Cyclic GMP; Disease Models, Animal; Double-Blind Method; Female; Guanylate Cyclase; Humans; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Natriuretic Peptides; Nociceptors; Peptides; Receptors, Atrial Natriuretic Factor; Receptors, Enterotoxin; Receptors, Guanylate Cyclase-Coupled; Receptors, Peptide; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2013 |
A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Colon; Disease Models, Animal; Eating; Edema; Humans; Inflammatory Bowel Diseases; Infliximab; Male; Peptides, Cyclic; Peroxidase; Prednisolone; Rats; Rats, Wistar; Receptor, Anaphylatoxin C5a; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease.
Topics: Adult; Animals; Annexin A5; Antibodies, Monoclonal; Apoptosis; CD4-Positive T-Lymphocytes; Colitis; Crohn Disease; Disease Models, Animal; Female; Gastrointestinal Agents; Humans; Infliximab; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Middle Aged; Organotechnetium Compounds; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.
Topics: Animals; Butyrates; Colitis; Colon; Disease Models, Animal; Enema; Ion Transport; Male; Mucous Membrane; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
892 other study(ies) available for trinitrobenzenesulfonic acid and Disease Models, Animal
| Article | Year |
|---|---|
Colonic inflammation induces changes in glucose levels through modulation of incretin system.
Topics: Adult; Animals; Blood Glucose; Case-Control Studies; Colitis; Crohn Disease; Dipeptidyl Peptidase 4; Disease Models, Animal; Female; Glucagon-Like Peptide 1; Humans; Incretins; Inflammation; Male; Mice; Mice, Inbred C57BL; Middle Aged; Proprotein Convertase 1; Trinitrobenzenesulfonic Acid; Young Adult | 2021 |
Intracolic ultrasound molecular imaging: a novel method for assessing colonic tumor necrosis factor-α expression in inflammatory bowel disease.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fluorescent Antibody Technique; Gene Expression; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Linear Models; Male; Mice, Inbred BALB C; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Ultrasonography | 2021 |
Magnetic resonance colonography assessment of acute trinitrobenzene sulfonic acid colitis in pre-pubertal rats.
Topics: Animals; Colitis; Cyclooxygenase 2; Disease Models, Animal; Interleukin-1beta; Magnetic Resonance Imaging; Male; Mice; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation.
Topics: Alkanesulfonic Acids; Animals; Colitis; Cytokines; Disease Models, Animal; Fluorocarbons; Homeostasis; Inflammation; Intestinal Mucosa; Mice; Trinitrobenzenesulfonic Acid; Zebrafish | 2021 |
Bone marrow mesenchymal stem cells combined with
Topics: Animals; Atractylodes; Cell Line; Cell Movement; Coculture Techniques; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Plant Extracts; Polysaccharides; Protein Array Analysis; Rats; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2022 |
Effect of Coptis chinensis franch and Magnolia officinalis on intestinal flora and intestinal barrier in a TNBS-induced ulcerative colitis rats model.
Topics: Animals; Colitis, Ulcerative; Colon; Coptis chinensis; Disease Models, Animal; Gastrointestinal Microbiome; Magnolia; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Therapeutic effect of Patrinia villosa on TNBS-induced ulcerative colitis via metabolism, vitamin D receptor and NF-κB signaling pathways.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Male; NF-kappa B; Patrinia; Plant Extracts; Rats; Rats, Sprague-Dawley; Receptors, Calcitriol; Signal Transduction; Trinitrobenzenesulfonic Acid | 2022 |
Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats.
Topics: Aminopyridines; Animals; Benzamides; Colitis; Cyclopropanes; Disease Models, Animal; Mice; Peroxidase; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Efficacy of a functional food ingredient from
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Food Ingredients; Functional Food; Mice; NF-kappa B; Plant Extracts; Rats; Trinitrobenzenesulfonic Acid | 2022 |
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease.
Topics: Animals; Colitis; Colon; Crohn Disease; Disease Models, Animal; Rats; Rats, Sprague-Dawley; Rodentia; Stress, Mechanical; Trinitrobenzenesulfonic Acid | 2022 |
Possible Curative Effects of Boric Acid and Bacillus clausii Treatments on TNBS-Induced Ulcerative Colitis in Rats.
Topics: Animals; Antioxidants; Bacillus clausii; Colitis, Ulcerative; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukins; Peroxidase; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2023 |
Peptide YY 3-36 attenuates trinitrobenzene sulfonic acid-induced colitis in mice by modulating Th1/Th2 differentiation.
Topics: Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Interleukin-6; Mice; Mice, Inbred BALB C; Peptide YY; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Chronic Experimental Model of TNBS-Induced Colitis to Study Inflammatory Bowel Disease.
Topics: Animals; Chronic Disease; Colitis; Colon; Disease Models, Animal; Ethanol; Female; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Topics: Animals; Bacillus amyloliquefaciens; Camelus; Colitis; Colon; Cytokines; Disease Models, Animal; Mice; Milk; Peroxidase; Proliferating Cell Nuclear Antigen; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
MFE40-the active fraction of Mume Fructus alcohol extract-alleviates Crohn's disease and its complications.
Topics: Animals; Citrates; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Ethanol; Inflammation; Interleukin-17; Interleukin-6; Intestinal Obstruction; Lipopolysaccharides; Lung Injury; Occludin; Rats; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid | 2022 |
Polydatin alleviates DSS- and TNBS-induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3.
Topics: Animals; Cell Differentiation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Glucosides; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor; Stilbenes; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2022 |
Buspirone Ameliorates Colon Inflammation in TNBS-Induced Rat Acute Colitis: The Involvement of TLR4/NF-kB Pathway.
Topics: Animals; Anti-Inflammatory Agents; Buspirone; Colitis; Colon; Dexamethasone; Disease Models, Animal; Inflammation; Male; NF-kappa B; Rats; Rats, Wistar; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis.
Topics: Animals; Autophagy; Basigin; Colitis; Collagen; Colon; Disease Models, Animal; Ethanol; Fibrosis; Mice; Phenols; RNA, Messenger; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2022 |
The ethanol extract of Periplaneta Americana L. improves ulcerative colitis induced by a combination of chronic stress and TNBS in rats.
Topics: Adrenocorticotropic Hormone; Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Enema; Ethanol; Periplaneta; Plant Extracts; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Leukocyte L1 Antigen Complex; Mice; Topiramate; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Mesenchymal stem cell transplantation worsens intestinal inflammation and microenvironment in PI3Kγ-knockout mice.
Topics: Animals; Benzene; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Cytokines; Disease Models, Animal; Immunoglobulin A; Inflammation; Interleukin-10; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Knockout; Occludin; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid | 2022 |
Human umbilical cord-derived mesenchymal stem cells ameliorate experimental colitis by normalizing the gut microbiota.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Mesenchymal Stem Cells; Mice; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2022 |
Radix Panacis quinquefolii Extract Ameliorates Inflammatory Bowel Disease through Inhibiting Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Lipopolysaccharides; Trinitrobenzenesulfonic Acid; Zebrafish | 2023 |
Effect of exogenous galectin-9, a natural TIM-3 ligand, on the severity of TNBS- and DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Galectins; Hepatitis A Virus Cellular Receptor 2; Inflammatory Bowel Diseases; Interleukin-6; Ligands; Mice; Mice, Inbred C57BL; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2023 |
Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis.
Topics: Animals; Avena; Butyrates; Colitis; Disease Models, Animal; Inflammation; Trinitrobenzenesulfonic Acid | 2023 |
Therapeutic effect of Yiyi Fuzi Baijiang formula on TNBS-induced ulcerative colitis via metabolism and Th17/Treg cell balance.
Topics: Animals; Biomarkers; Caspases; Chromatography, Liquid; Colitis, Ulcerative; Colon; Disease Models, Animal; Interleukin-18; Interleukin-6; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; T-Lymphocytes, Regulatory; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2023 |
Response Variability to Drug Testing in Two Models of Chemically Induced Colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Male; Mice; Trinitrobenzenesulfonic Acid | 2023 |
Dynamic alterations in metabolomics and transcriptomics associated with intestinal fibrosis in a 2,4,6-trinitrobenzene sulfonic acid-induced murine model.
Topics: Animals; Colitis; Disease Models, Animal; Metabolomics; Mice; Transcriptome; Trinitrobenzenesulfonic Acid | 2023 |
Human umbilical cord mesenchymal stem cells alleviated TNBS-induced colitis in mice by restoring the balance of intestinal microbes and immunoregulation.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Humans; Immunity; Inflammatory Bowel Diseases; Mesenchymal Stem Cells; Mice; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2023 |
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
Topics: Animals; Apoptosis; Caco-2 Cells; Case-Control Studies; Caspase 3; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Occludin; Signal Transduction; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2019 |
Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Liposomes; Male; Mesalamine; Mice; Mice, Inbred BALB C; Peroxidase; Quality of Life; Trinitrobenzenesulfonic Acid | 2019 |
Changes in colonic contractility in response to inflammatory bowel disease: Long-term assessment in a model of TNBS-induced inflammation in rats.
Topics: Animals; Colitis; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Muscle Contraction; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2019 |
Protective effect of adipose tissue-derived mesenchymal stromal cells in an experimental model of high-risk colonic anastomosis.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colitis; Colon; Disease Models, Animal; Humans; Intra-Abdominal Fat; Male; Mesenchymal Stem Cell Transplantation; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2019 |
Serotonin exerts a direct modulatory role on bladder afferent firing in mice.
Topics: Afferent Pathways; Animals; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Granisetron; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred C57BL; Neurons; Neurons, Afferent; Peripheral Nervous System; Receptors, Serotonin, 5-HT3; Serotonin; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Trinitrobenzenesulfonic Acid; Urinary Bladder | 2019 |
Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome.
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Inflammasomes; Inflammation; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Moxibustion; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Receptors, Vasopressin; Signal Transduction; Specific Pathogen-Free Organisms; Trinitrobenzenesulfonic Acid | 2019 |
Activation of pruritogenic TGR5, MrgprA3, and MrgprC11 on colon-innervating afferents induces visceral hypersensitivity.
Topics: Abdominal Pain; Adolescent; Adult; Animals; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Healthy Volunteers; Humans; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Mice; Middle Aged; Nociception; Receptors, G-Protein-Coupled; Sensory Receptor Cells; Trinitrobenzenesulfonic Acid; Young Adult | 2019 |
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Intestinal Mucosa; Intestines; Mice; Sirolimus; Trinitrobenzenesulfonic Acid | 2019 |
Topics: Animals; Clostridium butyricum; Dendritic Cells; Disease Models, Animal; Humans; Immunity, Mucosal; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Mice; Mice, Inbred C57BL; Probiotics; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2019 |
Beneficial Effects of Oat Beta-Glucan Dietary Supplementation in Colitis Depend on its Molecular Weight.
Topics: Animals; Anti-Inflammatory Agents; Avena; beta-Glucans; Colitis; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation; Lymphocyte Count; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2019 |
Amelioration of colitis in mice by Leuconostoc lactis EJ-1 by M1 to M2 macrophage polarization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-1beta; Interleukin-6; Leuconostoc; Lipopolysaccharides; Macrophages, Peritoneal; Mice; NF-kappa B; Plants, Edible; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Healing effects of Cornus mas L. in experimentally induced ulcerative colitis in rats: From ethnobotany to pharmacology.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis, Ulcerative; Colon; Cornus; Disease Models, Animal; Ethnobotany; Ethnopharmacology; Gastrointestinal Agents; Inflammation Mediators; Interleukin-1beta; Male; Oxidative Stress; Plant Extracts; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Wound Healing | 2020 |
Nucleus tractus solitarius mediates hyperalgesia induced by chronic pancreatitis in rats.
Topics: Afferent Pathways; Animals; Chronic Pain; Disease Models, Animal; Enteric Nervous System; Humans; Hyperalgesia; Male; Neurons; Pancreas; Pancreatitis, Chronic; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Solitary Nucleus; Stereotaxic Techniques; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2019 |
Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism.
Topics: Animals; Colon; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Exosomes; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Macrophage Activation; Macrophages; Male; Mesenchymal Stem Cells; Mice; Trinitrobenzenesulfonic Acid | 2019 |
Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger.
Topics: Animals; Binding Sites; Carbonic Anhydrases; Colitis; Colon; Disease Models, Animal; Down-Regulation; Ileum; Injections, Spinal; Male; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Male; Mice; Microbiota; Mucous Membrane; Trinitrobenzenesulfonic Acid | 2019 |
Preclinical Model of Perianal Fistulizing Crohn's Disease.
Topics: Anal Canal; Animals; Crohn Disease; Disease Models, Animal; Proctitis; Rats; Rectal Fistula; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2020 |
Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice.
Topics: Animals; Collagen Type III; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoglobulin G; Interleukin-17; Interleukin-1beta; Intestinal Mucosa; Intestines; Matrix Metalloproteinase 2; Mice; Reverse Transcriptase Polymerase Chain Reaction; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2020 |
Altered microbial community structure in PI3Kγ knockout mice with colitis impeding relief of inflammation: Establishment of new indices for intestinal microbial disorder.
Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Mice, Knockout; Microbiota; RNA, Ribosomal, 16S; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Electroacupuncture Relieves Irritable Bowel Syndrome by Regulating IL-18 and Gut Microbial Dysbiosis in a Trinitrobenzene Sulfonic Acid-Induced Post-Inflammatory Animal Model.
Topics: Animals; Disease Models, Animal; Dysbiosis; Electroacupuncture; Gastrointestinal Microbiome; Interleukin-18; Irritable Bowel Syndrome; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2020 |
KGF Is Delivered to Inflammatory and Induces the Epithelial Hyperplasia in Trinitrobenzene Sulfonic Acid-Induced Ulcerative Colitis Rats.
Topics: Animals; Cell Proliferation; Cells, Cultured; Colitis, Ulcerative; Disease Models, Animal; Female; Fibroblast Growth Factor 7; Hyperplasia; Inflammation; Injections, Intravenous; Intestinal Mucosa; Lentivirus; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2020 |
Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat.
Topics: Animals; Apoptosis; Blood Platelets; Colitis; Combined Modality Therapy; Cytokines; Disease Models, Animal; Gastrointestinal Agents; Inflammatory Bowel Diseases; Male; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Sulfasalazine; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2020 |
The Proteolytic Fraction From Vasconcellea cundinamarcensis Latex Displays Anti-Inflammatory Effect in A Mouse Model of Acute TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Caricaceae; Colitis; Colon; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Hexosaminidases; Humans; Inflammation Mediators; Latex; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Peroxidase; Proteolysis; Trinitrobenzenesulfonic Acid; Weight Loss | 2020 |
Effect of T. spiralis Serine protease inhibitors on TNBS-induced experimental colitis mediated by Macrophages.
Topics: Animals; Arginase; Autoimmunity; Colitis; Disease Models, Animal; Inflammation; Interleukin-33; Janus Kinase 2; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Phenotype; Phosphorylation; Recombinant Proteins; Serine Proteinase Inhibitors; STAT3 Transcription Factor; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2020 |
lncRNACNN3-206 activates intestinal epithelial cell apoptosis and invasion by sponging miR-212, an implication for Crohn's disease.
Topics: 3' Untranslated Regions; Adolescent; Adult; Animals; Apoptosis; Caco-2 Cells; Caspase 10; Cell Movement; Crohn Disease; Disease Models, Animal; Epithelial Cells; Female; Gene Expression Profiling; Gene Knockdown Techniques; HT29 Cells; Humans; Intestinal Mucosa; Male; Mice; MicroRNAs; Middle Aged; RNA, Long Noncoding; RNA, Small Interfering; Tissue Array Analysis; Trinitrobenzenesulfonic Acid; Young Adult | 2020 |
MiR-195 alleviates ulcerative colitis in rats via MAPK signaling pathway.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Ethanol; Injections, Subcutaneous; MAP Kinase Signaling System; MicroRNAs; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium animalis; Citrobacter rodentium; Colitis; Dendritic Cells; Disease Models, Animal; Enterobacteriaceae Infections; Female; Gastrointestinal Microbiome; Germ-Free Life; Limosilactobacillus reuteri; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Pancreatitis-Associated Proteins; Probiotics; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2020 |
miR-802 participates in the inflammatory process of inflammatory bowel disease by suppressing SOCS5.
Topics: Adult; Animals; Case-Control Studies; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Colitis, Ulcerative; Colon; Crohn Disease; Disease Models, Animal; Female; Healthy Volunteers; Humans; Interleukin-17; Intestinal Mucosa; Male; Mice; MicroRNAs; Primary Cell Culture; Suppressor of Cytokine Signaling Proteins; Th17 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2020 |
Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Colonic Diseases; Cytokines; Disease Models, Animal; Diterpenes; Epithelium; Female; Fibrosis; Inflammation; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; T-Lymphocyte Subsets; Trinitrobenzenesulfonic Acid | 2020 |
Protective effect of baicalin on the regulation of Treg/Th17 balance, gut microbiota and short-chain fatty acids in rats with ulcerative colitis.
Topics: Animals; Butyrates; Colitis, Ulcerative; Disease Models, Animal; Dysbiosis; Fatty Acids, Volatile; Flavonoids; Gastrointestinal Microbiome; Gastrointestinal Tract; Prebiotics; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2020 |
Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.
Topics: Animals; Colitis; Disease Models, Animal; Energy Metabolism; Inflammation; Intestine, Small; Mitochondria; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid; Uncoupling Protein 2 | 2020 |
Evaluation of protein arginine deiminase-4 inhibitor in TNBS- induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Extracellular Traps; Female; Mice, Inbred BALB C; Ornithine; Protein-Arginine Deiminase Type 4; Trinitrobenzenesulfonic Acid | 2020 |
Effects of Yacon on Colonic IFN-γ and Goblet Cells of 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Mouse Model.
Topics: Animals; Cell Count; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Goblet Cells; Interferon-gamma; Male; Mice, Inbred BALB C; Plant Tubers; Trinitrobenzenesulfonic Acid | 2020 |
Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Disease Susceptibility; Fluvoxamine; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Inflammation Mediators; Interleukin-6; Ligands; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Protein Binding; Rats; Receptors, sigma; Severity of Illness Index; Sigma-1 Receptor; Signal Transduction; Trinitrobenzenesulfonic Acid; Ubiquitin Thiolesterase | 2020 |
Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways.
Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Caspase 1; Colitis; Colon; Cytoprotection; Diosgenin; Disease Models, Animal; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Sacral nerve stimulation ameliorates colonic barrier functions in a rodent model of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Electric Stimulation Therapy; Electrodes, Implanted; Lumbosacral Plexus; Male; Rats; Rats, Sprague-Dawley; Rodentia; Trinitrobenzenesulfonic Acid | 2020 |
Polyphenolic Maqui Extract as a Potential Nutraceutical to Treat TNBS-Induced Crohn's Disease by the Regulation of Antioxidant and Anti-Inflammatory Pathways.
Topics: Acute-Phase Reaction; Administration, Oral; Animals; Anti-Inflammatory Agents; Antioxidants; Crohn Disease; Cyclooxygenase 2; Dietary Supplements; Disease Models, Animal; Fruit; Heme Oxygenase-1; Inflammation Mediators; Male; Membrane Proteins; Mice, Inbred BALB C; NF-E2-Related Factor 2; Nitric Oxide Synthase Type II; Nutritional Physiological Phenomena; Phytotherapy; Polyphenols; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Drug release in vivo and efficacy evaluation of a new colon targeted powder of total saponins of Pulsatilla.
Topics: Animals; Biological Availability; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Compounding; Drug Liberation; Gastrointestinal Agents; Hydrogen-Ion Concentration; Male; Polymethacrylic Acids; Powders; Rats, Sprague-Dawley; Saponins; Solubility; Trinitrobenzenesulfonic Acid | 2020 |
Effect of recombinant serine protease from adult stage of Trichinella spiralis on TNBS-induced experimental colitis in mice.
Topics: Aging; Animals; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; Helminth Proteins; Mice, Inbred BALB C; Recombinant Proteins; Serine Proteases; Spleen; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Th2 Cells; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2020 |
RNF8 induces autophagy and reduces inflammation by promoting AKT degradation via ubiquitination in ulcerative colitis mice.
Topics: Animals; Autophagy; Cell Line, Tumor; Colitis, Ulcerative; Disease Models, Animal; Humans; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Proteolysis; Proto-Oncogene Proteins c-akt; Signal Transduction; Trinitrobenzenesulfonic Acid; Ubiquitin-Protein Ligases; Ubiquitination | 2020 |
Beneficial effect of Bidens pilosa L. (Asteraceae) in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bidens; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Inflammation; Leukocytes; Oxidative Stress; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2020 |
Transcriptome Based Profiling of the Immune Cell Gene Signature in Rat Experimental Colitis and Human IBD Tissue Samples.
Topics: Adult; Aged; Animals; Biopsy; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Rats; Sequence Analysis, RNA; Trinitrobenzenesulfonic Acid | 2020 |
Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation.
Topics: Animals; Bacillus subtilis; Bifidobacterium breve; Colitis; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Inflammation Mediators; Intestines; Lacticaseibacillus casei; Mice; Probiotics; Streptococcus thermophilus; Trinitrobenzenesulfonic Acid | 2020 |
IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE
Topics: Animals; Cells, Cultured; Chitosan; Colitis, Ulcerative; Colon; Dinoprostone; Disease Models, Animal; Drug Carriers; Female; Humans; Hydrogels; Insulin-Like Growth Factor I; Intestinal Mucosa; Macrophage Activation; Macrophages, Peritoneal; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Placenta; Pregnancy; Primary Cell Culture; Trinitrobenzenesulfonic Acid | 2020 |
Hyptis suaveolens (L.) Poit protects colon from TNBS-induced inflammation via immunomodulatory, antioxidant and anti-proliferative mechanisms.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cell Proliferation; Colitis, Ulcerative; Disease Models, Animal; Hyptis; Immunologic Factors; Inflammation; Male; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2021 |
Translational research into the effects of cigarette smoke on inflammatory mediators and epithelial TRPV1 in Crohn's disease.
Topics: Adult; Aged; Animals; Caco-2 Cells; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; HT29 Cells; Humans; Ileum; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Middle Aged; Tobacco Smoking; Translational Research, Biomedical; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2020 |
Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish.
Topics: Animals; Cholinergic Neurons; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Intestines; Trinitrobenzenesulfonic Acid; Zebrafish | 2020 |
In vitro and in vivo amelioration of colitis using targeted delivery system of cyclosporine a in New Zealand rabbits.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cyclosporine; Disease Models, Animal; Rabbits; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Extracellular vesicles derived from human placental mesenchymal stem cells alleviate experimental colitis in mice by inhibiting inflammation and oxidative stress.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Epithelial Cells; Extracellular Vesicles; Female; Humans; Immunologic Factors; Inflammation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Oxidative Stress; Placenta; Pregnancy; Trinitrobenzenesulfonic Acid | 2020 |
In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of
Topics: Adult; Animals; Bacteroidetes; Caco-2 Cells; Colitis; Disease Models, Animal; DNA, Bacterial; Feces; Female; Gastrointestinal Microbiome; Humans; Infant, Newborn; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2020 |
Qingchang Huashi granule ameliorates experimental colitis via restoring the dendritic cell-mediated Th17/Treg balance.
Topics: Animals; Cell Differentiation; Colitis, Ulcerative; Dendritic Cells; Disease Models, Animal; Drugs, Chinese Herbal; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2020 |
Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions.
Topics: Adiponectin; Animals; Bifidobacterium animalis; Cold Temperature; Colitis; Colon; Cytokines; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation Mediators; Inulin; Lactobacillus; Lactobacillus acidophilus; Lactobacillus plantarum; Male; Rats, Wistar; Synbiotics; Trinitrobenzenesulfonic Acid | 2020 |
Evaluation of the effect of Dahuang-Mudan decoction on TNBS-induced colitis using UPLC-QTOF/MS-based metabolomic analysis.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Mass Spectrometry; Metabolome; Metabolomics; Rats; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2021 |
Copaifera malmei Harms leaves infusion attenuates TNBS-ulcerative colitis through modulation of cytokines, oxidative stress and mucus in experimental rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Fabaceae; Inflammation Mediators; Male; Mucus; Oxidative Stress; Plant Extracts; Plant Leaves; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2021 |
Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model.
Topics: Animals; Bacterial Proteins; Chaperonin 60; Colitis; Cytokines; Disease Models, Animal; Female; Fibrosis; Immunoglobulin A; Lactococcus lactis; Mice, Inbred BALB C; Microorganisms, Genetically-Modified; Trinitrobenzenesulfonic Acid | 2020 |
A polymeric diet rich in transforming growth factor beta 2 does not reduce inflammation in chronic 2,4,6-trinitrobenzene sulfonic acid colitis in pre-pubertal rats.
Topics: Animals; Colitis; Colon; Diet; Disease Models, Animal; Inflammation; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2020 |
Jiaolong capsule protects SD rats against 2,4,6-trinitrobenzene sulfonic acid induced colitis.
Topics: Acetic Acid; Animals; Behavior, Animal; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Down-Regulation; Drugs, Chinese Herbal; Female; Gastrointestinal Agents; Gastrointestinal Microbiome; Mice, Inbred ICR; NF-kappa B; NF-KappaB Inhibitor alpha; Pain; Protective Agents; Rats, Sprague-Dawley; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2021 |
Dilodendron bipinnatum Radlk. extract alleviates ulcerative colitis induced by TNBS in rats by reducing inflammatory cell infiltration, TNF-α and IL-1β concentrations, IL-17 and COX-2 expressions, supporting mucus production and promotes an antioxidant ef
Topics: Animals; Antioxidants; Brazil; Caco-2 Cells; Cell Survival; Colitis, Ulcerative; Cyclooxygenase 2; Disease Models, Animal; Edema; Glutathione; Humans; Interleukin-17; Interleukin-1beta; Interleukin-8; Lipopolysaccharides; Mast Cells; Mucus; Peroxidase; Plant Bark; Plant Extracts; Rats, Wistar; Sapindaceae; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
Long Non-coding RNA MEG3 Alleviated Ulcerative Colitis Through Upregulating miR-98-5p-Sponged IL-10.
Topics: Animals; Apoptosis; Caco-2 Cells; Colitis, Ulcerative; Colon; Disease Models, Animal; Humans; Hydrogen Peroxide; Inflammation Mediators; Interleukin-10; Intestinal Mucosa; MicroRNAs; Pyroptosis; Rats, Sprague-Dawley; RNA, Long Noncoding; Trinitrobenzenesulfonic Acid; Up-Regulation | 2021 |
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Integrin alpha Chains; Integrin alpha2; Integrin alpha6; Intestinal Mucosa; Mice, Inbred BALB C; Prolyl-Hydroxylase Inhibitors; Protein Stability; Signal Transduction; Trinitrobenzenesulfonic Acid; Wound Healing | 2021 |
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Microbiome; Immune Checkpoint Inhibitors; Male; Mesalamine; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Protective Agents; Trinitrobenzenesulfonic Acid | 2021 |
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.
Topics: Animals; Bacterial Proteins; Channelrhodopsins; Colitis; Colon; Disease Models, Animal; Fructose; Ganglia, Spinal; Glycerol; Immunohistochemistry; Luminescent Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Rectum; Sensory Receptor Cells; Solutions; Tissue Fixation; Trinitrobenzenesulfonic Acid; Vesicular Glutamate Transport Protein 2 | 2021 |
Integrative transcriptomic and metabonomic profiling analyses reveal the molecular mechanism of Chinese traditional medicine huankuile suspension on TNBS-induced ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Drugs, Chinese Herbal; Gene Expression Profiling; Interleukin-10; Interleukin-1beta; Interleukin-4; Interleukin-6; Intestinal Mucosa; Mesalamine; Metabolomics; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
2,4,6-trinitrobenzenesulfonic acid-induced colitis in Rattus norgevicus: a categorization proposal.
Topics: Animals; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Male; Rats; Rats, Wistar; Retrospective Studies; Trinitrobenzenesulfonic Acid | 2021 |
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Disease Models, Animal; Eicosanoids; Fatty Acids, Omega-3; Inflammation; Mice, Transgenic; Trinitrobenzenesulfonic Acid | 2021 |
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion.
Topics: Animals; Behavior, Animal; Bile Ducts; Disease Models, Animal; Humans; Injections; Male; Mice, Inbred C57BL; Pancreatitis, Chronic; Solutions; Trinitrobenzenesulfonic Acid | 2021 |
Structure-based design of a Cortistatin analogue with immunomodulatory activity in models of inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Tract; Humans; Immunologic Factors; Immunomodulation; Inflammation; Male; Mice; Mice, Inbred C57BL; Molecular Conformation; Neuropeptides; Trinitrobenzenesulfonic Acid | 2021 |
Dapsone Ameliorates Colitis through TLR4/NF-kB Pathway in TNBS Induced Colitis Model in Rat.
Topics: Animals; Colitis; Colon; Dapsone; Disease Models, Animal; Humans; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2021 |
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling.
Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Middle Aged; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2021 |
HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylurea Compounds; Protein Serine-Threonine Kinases; Pyrimidines; Transcription Factors; Trinitrobenzenesulfonic Acid | 2021 |
Exploration of the potential mechanism of Banxia Xiexin Decoction for the effects on TNBS-induced ulcerative colitis rats with the assistance of network pharmacology analysis.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Inflammation; Male; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2021 |
Mouse Models of Intestinal Fibrosis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Escherichia coli; Humans; Interleukin-10; Male; Mice; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2021 |
Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
Topics: Amino Acid Sequence; Ancylostoma; Ancylostomatoidea; Animals; Cell Proliferation; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation Mediators; Intestines; Kv1.3 Potassium Channel; Leukocytes; Magnetic Resonance Spectroscopy; Male; Mice, Inbred C57BL; Necator americanus; Peptides; Principal Component Analysis; Protein Domains; Protein Folding; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Xenopus laevis | 2021 |
Atractylenolide III Ameliorates TNBS-Induced Intestinal Inflammation in Mice by Reducing Oxidative Stress and Regulating Intestinal Flora.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Down-Regulation; Gastrointestinal Microbiome; Interleukin-1beta; Lactones; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2021 |
Protection by microRNA-7a-5p Antagomir Against Intestinal Mucosal Injury Related to the JNK Pathway in TNBS-Induced Experimental Colitis.
Topics: Animals; Antagomirs; Colitis; Disease Models, Animal; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid | 2021 |
Curcumin improves experimentally induced colitis in mice by regulating follicular helper T cells and follicular regulatory T cells by inhibiting interleukin-21.
Topics: Animals; Colitis; Curcumin; Disease Models, Animal; Flow Cytometry; Interleukins; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; T Follicular Helper Cells; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2021 |
Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation.
Topics: Animals; Colitis; Diet; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Myofibroblasts; Rats; Salts; Trinitrobenzenesulfonic Acid | 2021 |
Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation Mediators; Intestinal Mucosa; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Permeability; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Sulfonamides; Tight Junction Proteins; Tight Junctions; Trinitrobenzenesulfonic Acid | 2021 |
IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis.
Topics: Adoptive Transfer; Adult; Animals; Biopsy; Colitis; Colon; Colonoscopy; Disease Models, Animal; Female; Humans; Injections, Intraperitoneal; Interleukin-33; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Middle Aged; Recombinant Proteins; Th2 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Protective effects of tranilast on experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; ortho-Aminobenzoates; Peroxidase; Protective Agents; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Male; Mesalamine; Methylamines; Nitrates; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestines; Mice; Mice, Inbred BALB C; Tramadol; Trinitrobenzenesulfonic Acid | 2017 |
PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; Colitis; Crohn Disease; Disease Models, Animal; DNA-Binding Proteins; Epithelial Cells; Humans; Interferon-gamma; Intestinal Mucosa; Intestines; Mice; Transcription Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2017 |
Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Clostridium butyricum; Colitis; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Inflammation; Interleukin-12; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Inhibition of the high affinity choline transporter enhances hyperalgesia in a rat model of chronic pancreatitis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hemicholinium 3; Hyperalgesia; Injections, Intraperitoneal; Male; Nerve Tissue Proteins; Pancreatitis, Chronic; Plasma Membrane Neurotransmitter Transport Proteins; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid | 2017 |
The effect of sphingosine-1-phosphate on colonic smooth muscle contractility: Modulation by TNBS-induced colitis.
Topics: Animals; Calcium; Colitis, Ulcerative; Colon; Disease Models, Animal; Humans; Inflammation; Lysophospholipids; Muscle Contraction; Muscle, Smooth; Rats; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Thapsigargin; Trinitrobenzenesulfonic Acid | 2017 |
Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis.
Topics: Animals; Cell Count; Colitis; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Neurons; Rats; Rats, Wistar; Receptors, Purinergic P2X7; Submucous Plexus; Trinitrobenzenesulfonic Acid | 2017 |
Critical Role of P2Y
Topics: Adenosine; Animals; Autoimmune Diseases; Cell Differentiation; Cells, Cultured; Clopidogrel; Colitis; Diabetes Mellitus, Experimental; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Th17 Cells; Ticagrelor; Ticlopidine; Trinitrobenzenesulfonic Acid | 2017 |
Percutaneous electrical nerve field stimulation modulates central pain pathways and attenuates post-inflammatory visceral and somatic hyperalgesia in rats.
Topics: Animals; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Neurons; Rats, Sprague-Dawley; Spinal Cord; Transcutaneous Electric Nerve Stimulation; Trinitrobenzenesulfonic Acid; Visceral Pain | 2017 |
Combined Treatment with Hyaluronic Acid and Mesalamine Protects Rats from Inflammatory Bowel Disease Induced by Intracolonic Administration of Trinitrobenzenesulfonic Acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Hyaluronic Acid; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Protective Agents; Rats; Trinitrobenzenesulfonic Acid | 2017 |
Inhibition of gelatinase B/MMP-9 does not attenuate colitis in murine models of inflammatory bowel disease.
Topics: Animals; Colitis, Ulcerative; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Female; Gastrointestinal Agents; Humans; Male; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2017 |
Chemically induced mouse models of acute and chronic intestinal inflammation.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2017 |
Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Biomarkers; Carrier Proteins; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Gastrointestinal Agents; Glutathione; Inflammation Mediators; Lythraceae; Male; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice.
Topics: Animals; Cell Membrane Permeability; Colitis; Disease Models, Animal; Dysbiosis; Escherichia coli; Feces; Gastrointestinal Microbiome; Gastrointestinal Tract; Hippocampus; Humans; Inflammation; Lactobacillus johnsonii; Male; Memory Disorders; Mice; Mice, Inbred ICR; NF-kappa B; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; HT29 Cells; Humans; Indenes; Inflammatory Bowel Diseases; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2017 |
Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Fibrinogen; Gene Expression Regulation; Immunohistochemistry; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice, Inbred BALB C; Spleen; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors; Trinitrobenzenesulfonic Acid | 2017 |
Bifidobacterium longum affects the methylation level of forkhead box P3 promoter in 2, 4, 6-trinitrobenzenesulphonic acid induced colitis in rats.
Topics: Animals; Bifidobacterium longum; Colitis; Disease Models, Animal; DNA Methylation; Forkhead Transcription Factors; Inflammatory Bowel Diseases; Leukocytes, Mononuclear; Probiotics; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2017 |
Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis.
Topics: Action Potentials; Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Excitatory Postsynaptic Potentials; Lumbar Vertebrae; Male; Mice, Inbred C57BL; Patch-Clamp Techniques; Physical Stimulation; Posterior Horn Cells; Rectum; Sacrum; Skin; Trinitrobenzenesulfonic Acid; Visceral Pain | 2017 |
Total glucosides of paeony ameliorates TNBS‑induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines.
Topics: Animals; Biomarkers; Cell Differentiation; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glucosides; Male; Paeonia; Plant Extracts; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors; Trinitrobenzenesulfonic Acid | 2017 |
Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS-induced colitis by regulating CD4+ T cells in mesenteric lymph nodes.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Female; Interleukin-10; Interleukin-17; Loranthaceae; Lymph Nodes; Mice, Inbred BALB C; Peroxidase; Plant Extracts; Th17 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Immunity, Innate; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-27; Intestinal Mucosa; Male; Mice; Mice, Knockout; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2017 |
Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Bacteriocins; Cecum; Colitis; Colon; Disease Models, Animal; DNA, Bacterial; Feces; Gastrointestinal Microbiome; Gene Deletion; Inflammatory Bowel Diseases; Interleukin-6; Lactobacillus plantarum; Mice; Probiotics; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.
Topics: Animals; Bacteria; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Hepatocytes; Humans; Mice, Inbred C57BL; Mice, Transgenic; Microbial Viability; Oxidative Stress; Pancreatitis-Associated Proteins; Reactive Oxygen Species; Time Factors; Trinitrobenzenesulfonic Acid | 2018 |
Age, sex, and TNF associated differences in the gut microbiota of mice and their impact on acute TNBS colitis.
Topics: Age Factors; Animals; Bacteria; Colitis; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Humans; Male; Mice; Mice, Knockout; RNA, Ribosomal, 16S; Sex Characteristics; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Bifidobacteria alleviate experimentally induced colitis by upregulating indoleamine 2, 3-dioxygenase expression.
Topics: Animals; Bifidobacterium; Colitis; Colonic Diseases; Disease Models, Animal; Female; Forkhead Transcription Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tryptophan; Up-Regulation | 2018 |
Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Disease Models, Animal; Fruit and Vegetable Juices; Inflammatory Bowel Diseases; Male; Photinia; Plant Extracts; Rats; Rats, Wistar; Sulfasalazine; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid | 2018 |
Chronic cigarette smoke exposure induces systemic hypoxia that drives intestinal dysfunction.
Topics: Adult; Aged; Amino Acids, Dicarboxylic; Animals; Biopsy; Cell Hypoxia; Colon; Colonoscopy; Crohn Disease; Disease Models, Animal; Disease Progression; Female; Humans; Ileum; Intestinal Mucosa; Lung; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nicotiana; Oxidative Stress; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Pulmonary Disease, Chronic Obstructive; Pulmonary Gas Exchange; Risk Factors; Smoke; Smoking; Smoking Cessation; Time Factors; Trinitrobenzenesulfonic Acid | 2018 |
Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats.
Topics: Animals; Colon; Crohn Disease; Diarrhea; Disease Models, Animal; Gastrointestinal Agents; Humans; Intestinal Mucosa; Male; Necrosis; NF-kappa B; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Signal Transduction; Toll-Like Receptor 4; Treatment Outcome; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2018 |
New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Caco-2 Cells; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Humans; Hydrogen Peroxide; Immunomodulation; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Mice; Mice, Inbred BALB C; Permeability; Probiotics; Trinitrobenzenesulfonic Acid | 2018 |
Neuronal Transforming Growth Factor beta Signaling via SMAD3 Contributes to Pain in Animal Models of Chronic Pancreatitis.
Topics: Animals; Ceruletide; Disease Models, Animal; Fibrosis; Humans; Hyperalgesia; Male; Mice; Mice, Transgenic; Nociceptors; Pain; Pancreas; Pancreatitis, Chronic; Patch-Clamp Techniques; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Recombinant Proteins; Signal Transduction; Smad3 Protein; Synaptic Potentials; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2018 |
Thyroid Dysfunction, Neurological Disorder and Immunosuppression as the Consequences of Long-term Combined Stress.
Topics: Animals; Blood; Colitis, Ulcerative; Colon; Disease Models, Animal; Gene Expression Profiling; Hypothalamus; Immune Tolerance; Male; Nervous System Diseases; Rats; Rats, Wistar; Sequence Analysis, RNA; Stress, Psychological; Thyroid Diseases; Thyroxine; Triiodothyronine; Trinitrobenzenesulfonic Acid | 2018 |
MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokine CCL8 in the spinal cord in a mouse model of colitis.
Topics: Animals; Antagomirs; Antibodies; Cells, Cultured; Chemokine CCL8; Colitis; Disease Models, Animal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Peroxidase; RNA, Small Interfering; Spinal Cord; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation; Visceral Pain | 2018 |
Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice.
Topics: Animals; Cell Differentiation; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; GATA3 Transcription Factor; Inflammatory Bowel Diseases; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Proto-Oncogene Proteins c-pim-1; RNA, Messenger; T-Lymphocytes; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2018 |
Determination of the mitigating effect of colon-specific bioreversible codrugs of mycophenolic acid and aminosugars in an experimental colitis model in Wistar rats.
Topics: Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Liberation; Drug Synergism; Galactosamine; Gastric Mucosa; Glucosamine; Humans; Immunosuppressive Agents; Male; Mycophenolic Acid; Prodrugs; Rats; Rats, Wistar; Severity of Illness Index; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2018 |
Epiisopiloturine, an imidazole alkaloid, reverses inflammation and lipid peroxidation parameters in the Crohn disease model induced by trinitrobenzenosulfonic acid in Wistar rats.
Topics: 4-Butyrolactone; Alkaloids; Animals; Anti-Inflammatory Agents; Crohn Disease; Disease Models, Animal; Female; Imidazoles; Inflammation; Intestinal Mucosa; Lipid Peroxidation; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2018 |
Comparison of two models of inflammatory bowel disease in rats.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Oxidative Stress; Rats; Trinitrobenzenesulfonic Acid | 2018 |
Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice.
Topics: Animals; Colitis; Collagen Type I; Colon; Crohn Disease; Disease Models, Animal; Down-Regulation; Female; Fibrosis; Gene Knockdown Techniques; Mice; Mice, Inbred BALB C; Oligonucleotides; Oligonucleotides, Antisense; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2018 |
BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis.
Topics: Animals; Cell Differentiation; Cells, Cultured; Colitis; Colon; Cytokines; Dendritic Cells; Disease Models, Animal; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Leukotriene B4; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Biological Availability; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Compounding; Gastrointestinal Agents; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Micelles; Neutrophil Infiltration; ortho-Aminobenzoates; Particle Size; Peroxidase; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2018 |
Anti-fibrogenic Potential of Mesenchymal Stromal Cells in Treating Fibrosis in Crohn's Disease.
Topics: Animals; Cells, Cultured; Colon; Crohn Disease; Disease Models, Animal; Epithelial-Mesenchymal Transition; Fibrosis; Gene Expression Regulation; Interleukins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice, Inbred BALB C; Phenotype; Phosphorylation; Signal Transduction; Smad2 Protein; Smad3 Protein; Stem Cell Niche; Time Factors; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2018 |
Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Fibrosis; Interleukin-12 Subunit p40; Interleukin-23; Intestines; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Vaccines, Subunit | 2018 |
Treatment with Obestatin-A Ghrelin Gene-Encoded Peptide-Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid.
Topics: Animals; Colitis; Disease Models, Animal; Ghrelin; Rats; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2018 |
NaV1.1 inhibition can reduce visceral hypersensitivity.
Topics: Animals; Chronic Pain; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Stability; Ganglia, Spinal; Humans; Irritable Bowel Syndrome; Male; Maximum Tolerated Dose; Mice; NAV1.1 Voltage-Gated Sodium Channel; Nociceptors; Pain Measurement; Trinitrobenzenesulfonic Acid; Visceral Pain; Voltage-Gated Sodium Channel Blockers | 2018 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; HT29 Cells; Humans; Indans; Inflammatory Bowel Diseases; Molecular Structure; Monocytes; Pyridines; Rats; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Intake of Protein Hydrolysates and Phenolic Fractions Isolated from Flaxseed Ameliorates TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Female; Flax; Inflammation Mediators; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenols; Protein Hydrolysates; RAW 264.7 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis.
Topics: Adipose Tissue; Animals; Cell Communication; Cell Differentiation; Cell Movement; Colitis; Disease Models, Animal; Genes, Reporter; Humans; Injections, Intraperitoneal; Intestinal Mucosa; Intestines; Liver; Luciferases; Luminescent Measurements; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Spleen; Trinitrobenzenesulfonic Acid | 2018 |
Lactobacillus acidophilus and Clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors.
Topics: Animals; Clostridium butyricum; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Intestines; Lactobacillus acidophilus; Male; Mice; Mice, Inbred BALB C; Probiotics; Rats, Sprague-Dawley; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Effect of two recombinant Trichinella spiralis serine protease inhibitors on TNBS-induced experimental colitis of mice.
Topics: Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Insulin-Like Growth Factor Binding Proteins; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Peroxidase; Serine Proteinase Inhibitors; T-Lymphocytes, Regulatory; Th2 Cells; Transcription Factor RelA; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2018 |
Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Budesonide; Colitis, Ulcerative; Disease Models, Animal; Humans; Hydrogen-Ion Concentration; Mice; Mice, Inbred Strains; Nanoparticles; Trinitrobenzenesulfonic Acid | 2018 |
Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects.
Topics: Animals; Cell Line; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Group IV Phospholipases A2; Lipopolysaccharides; Liver; Lysophospholipids; Macrophages; Male; Mice; Monoacylglycerol Lipases; Receptors, G-Protein-Coupled; Spleen; Tissue Distribution; Trinitrobenzenesulfonic Acid | 2018 |
Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel.
Topics: Adult; Animals; Cell Line; Chronic Disease; Colitis; Colon; Crohn Disease; Disease Models, Animal; Fibrosis; Humans; Male; Mice; Mice, Knockout; Middle Aged; Myofibroblasts; Panax; Plant Extracts; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; Zanthoxylum; Zingiberaceae | 2018 |
Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.
Topics: Adenomatous Polyposis Coli Protein; Animals; Bacteroides fragilis; Carcinogenesis; Cells, Cultured; Colitis; Colorectal Neoplasms; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
Topics: Afferent Pathways; Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Guanylyl Cyclase C Agonists; Humans; Hyperalgesia; Irritable Bowel Syndrome; Male; Mice; Neuronal Plasticity; Nociception; Peptides; Treatment Outcome; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urinary Bladder, Overactive | 2018 |
Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways.
Topics: Acute Disease; Animals; Benzopyrans; CARD Signaling Adaptor Proteins; Colitis; Disease Models, Animal; Inflammasomes; Inflammation; Inflammation Mediators; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2019 |
Oenothera rosea L´Hér. ex Ait attenuates acute colonic inflammation in TNBS-induced colitis model in rats: in vivo and in silico myeloperoxidase role.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Down-Regulation; Female; Inflammation; Interleukin-1beta; Intestinal Mucosa; Nitric Oxide; Oenothera; Peroxidase; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2018 |
The protective effects of Poria cocos-derived polysaccharide CMP33 against IBD in mice and its molecular mechanism.
Topics: Animals; Chromatography, High Pressure Liquid; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Fatty Acid-Binding Proteins; Haptoglobins; Hydroxymethylglutaryl-CoA Synthase; Inflammatory Bowel Diseases; Male; Malondialdehyde; Metabolomics; Mice; N-Acetylgalactosaminyltransferases; Peroxidase; Polysaccharides; Proteomics; Sulfasalazine; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Wolfiporia | 2018 |
Ginsenoside Rb1 promotes intestinal epithelial wound healing through extracellular signal-regulated kinase and Rho signaling.
Topics: Animals; Cell Line; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Ginsenosides; Intestinal Mucosa; Male; Panax; Plant Extracts; Rats, Wistar; rho GTP-Binding Proteins; Signal Transduction; Trinitrobenzenesulfonic Acid; Wound Healing; Zanthoxylum; Zingiberaceae | 2019 |
Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Humans; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th2 Cells; Therapy with Helminths; Trichinella spiralis; Trichinellosis; Trinitrobenzenesulfonic Acid | 2019 |
Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Immunomodulation; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th1 Cells; Th1-Th2 Balance; Th2 Cells; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2019 |
Gallic acid improved inflammation via NF-κB pathway in TNBS-induced ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Cell Proliferation; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Gallic Acid; Humans; Inflammation; Intestine, Small; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2019 |
Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.
Topics: Animals; Colitis; Colon; Dioscorea; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inulin; Male; Plant Extracts; Polysaccharides; Prebiotics; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2019 |
Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.
Topics: Animals; Colitis; Disease Models, Animal; Glycosides; Inflammatory Bowel Diseases; Interleukin-17; Interleukin-23; Male; Mice, Inbred BALB C; Paeonia; Phytotherapy; Specific Pathogen-Free Organisms; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.
Topics: Animals; Antigens, Ly; Bone Marrow Cells; Cell Movement; Colitis; Disease Models, Animal; Enteritis; Female; Humans; Intestinal Mucosa; Intestine, Small; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parabiosis; Paracrine Communication; Radiation Injuries, Experimental; Receptors, CXCR4; Trinitrobenzenesulfonic Acid; Wound Healing | 2019 |
Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Extracellular Vesicles; Interleukin-1 Receptor-Associated Kinases; Male; Mesenchymal Stem Cells; MicroRNAs; Rats, Sprague-Dawley; TNF Receptor-Associated Factor 6; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2019 |
Comparative Efficacy of Chitosan, Pectin Based Mesalamine Colon Targeted Drug Delivery Systems on TNBS-induced IBD Model Rats.
Topics: Animals; Anti-Inflammatory Agents; Chitosan; Colon; Disease Models, Animal; Drug Delivery Systems; Humans; Inflammatory Bowel Diseases; Mesalamine; Pectins; Rats; Rats, Wistar; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid; Ulcer | 2020 |
High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice.
Topics: Analgesia; Animals; Colitis; Disease Models, Animal; Male; Mice; Narcotic Antagonists; Peroxidase; Stress, Psychological; Trinitrobenzenesulfonic Acid | 2018 |
Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.
Topics: Animals; Bacteria; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Macrophages; Male; Mice, Inbred BALB C; Probiotics; Species Specificity; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2019 |
Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.
Topics: Acute Disease; Adaptive Immunity; Animals; Cell Membrane Permeability; Colitis; Disease Models, Animal; Epithelium; Immune Tolerance; Immunity, Innate; Inflammation; Male; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 2019 |
Inhibition of tumor necrosis factor alpha and increased of interleukin 10 by
Topics: Animals; Chickens; Colitis, Ulcerative; Colon; Disease Models, Animal; Female; Interleukin-10; Lactobacillus; Male; Probiotics; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Dendritic cells treated by Trichinella spiralis muscle larval excretory/secretory products alleviate TNBS-induced colitis in mice.
Topics: Animals; Antigens, Helminth; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Helminth Proteins; Humans; Immunotherapy; Inflammatory Bowel Diseases; Lymphocyte Activation; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th2 Cells; Therapy with Helminths; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2019 |
Investigation on Spectrum-Effect Correlation between Constituents Absorbed into Blood and Bioactivities of Baizhu Shaoyao San before and after Processing on Ulcerative Colitis Rats by UHPLC/Q-TOF-MS/MS Coupled with Gray Correlation Analysis.
Topics: Animals; Blood Chemical Analysis; Chromatography, High Pressure Liquid; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Drug Compounding; Drugs, Chinese Herbal; Male; Molecular Structure; Rats; Rats, Sprague-Dawley; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid | 2019 |
MiR-146a regulates the development of ulcerative colitis via mediating the TLR4/MyD88/NF-κB signaling pathway.
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Gene Expression Regulation; Male; MicroRNAs; Myeloid Differentiation Factor 88; NF-kappa B; Random Allocation; Rats; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2019 |
Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.
Topics: Animals; Colitis; Disease Models, Animal; Electroacupuncture; Hindlimb; Hyperalgesia; Long-Term Potentiation; Male; Nociception; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord; Trinitrobenzenesulfonic Acid | 2019 |
Ultrastructural changes in colonic epithelial cells in a rat model of inflammatory bowel disease.
Topics: Animals; Colon; Disease Models, Animal; Endoplasmic Reticulum; Epithelial Cells; Goblet Cells; Golgi Apparatus; Inflammatory Bowel Diseases; Male; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Mucins; Rats; Trinitrobenzenesulfonic Acid | 2019 |
Urine Proteome Changes in a TNBS-Induced Colitis Rat Model.
Topics: Animals; Colitis; Disease Models, Animal; Male; Proteomics; Rats; Rats, Wistar; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid | 2019 |
Potential Mechanisms of 3, 4-Oxo-Isopropylidene-Shikimic Acid in Ameliorating 2, 4, 6-Trinitrobenzenesulfonic Acid-Induced Colitis in Rats.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Shikimic Acid; Trinitrobenzenesulfonic Acid | 2019 |
Dihydroartemisinin Regulates the Th/Treg Balance by Inducing Activated CD4+ T cell Apoptosis via Heme Oxygenase-1 Induction in Mouse Models of Inflammatory Bowel Disease.
Topics: Animals; Apoptosis; Artemisinins; Colitis; Disease Models, Animal; Enzyme Induction; Heme Oxygenase-1; Inflammatory Bowel Diseases; Lymphocyte Activation; Lymphocyte Subsets; Mice; Oxazolone; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2019 |
Grape peel powder promotes intestinal barrier homeostasis in acute TNBS-colitis: A major role for dietary fiber and fiber-bound polyphenols.
Topics: Acute Disease; Animals; Chromatography, High Pressure Liquid; Colitis; Colon; Dietary Fiber; Disease Models, Animal; Fatty Acids, Volatile; Feces; Homeostasis; Hydrogen-Ion Concentration; Male; Permeability; Polyphenols; Powders; Rats; Rats, Wistar; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Vitis | 2019 |
Sacral nerve stimulation improves colonic inflammation mediated by autonomic-inflammatory cytokine mechanism in rats.
Topics: Animals; Autonomic Nervous System; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Electric Stimulation Therapy; Inflammation; Inflammatory Bowel Diseases; Lumbosacral Plexus; Rats; Trinitrobenzenesulfonic Acid; Vagus Nerve Stimulation | 2019 |
Regulatory mechanism of mesalazine on TLR4/MyD88-dependent pathway in mouse ulcerative colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Azathioprine; Colitis, Ulcerative; Colon; Disease Models, Animal; Down-Regulation; Ethanol; Humans; Intestinal Mucosa; Male; Mesalamine; Mice; MicroRNAs; Myeloid Differentiation Factor 88; Signal Transduction; Specific Pathogen-Free Organisms; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Up-Regulation | 2019 |
Supercritical Fluid Extract of
Topics: Angelica sinensis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Biopsy; Cell Survival; Chromatography, Supercritical Fluid; Colitis; Cytokines; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Inflammation Mediators; Lipopolysaccharides; Lymphocytes; Mice; Nitric Oxide; Plant Extracts; Rats; RAW 264.7 Cells; Spleen; Trinitrobenzenesulfonic Acid; Zingiber officinale | 2019 |
Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice.
Topics: Administration, Cutaneous; Animals; Biomarkers; Cells, Cultured; Colitis; Colon; Desensitization, Immunologic; Disease Models, Animal; Female; Immunoglobulins; Inflammation Mediators; Interferon-gamma; Interleukin-10; Interleukin-17; Mice; Neutrophils; Peroxidase; Severity of Illness Index; Skin; Spleen; Time Factors; Transdermal Patch; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2012 |
Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice.
Topics: Animals; Biomarkers; CD4 Lymphocyte Count; Colitis; Colon; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Inflammation Mediators; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Probiotics; Severity of Illness Index; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Chemically induced intestinal damage models in zebrafish larvae.
Topics: Alcian Blue; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Dextran Sulfate; Disease Models, Animal; Drug Discovery; Enterocolitis; Flow Cytometry; Humans; Immersion; Inflammation; Inflammatory Bowel Diseases; Interleukin-23; Intestines; Larva; Microinjections; Morpholinos; Neutral Red; Neutrophils; Nitric Oxide; Optical Imaging; Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Zebrafish; Zebrafish Proteins | 2013 |
Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis.
Topics: Amino Acids, Diamino; Animals; Body Weight; Colitis; Colon; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Intercellular Adhesion Molecule-1; Interleukin-1beta; Leukotriene B4; Male; Malondialdehyde; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Colitis; Colon; Cytokine TWEAK; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Humans; Immunoglobulins; Interleukin-13; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Culture Techniques; Receptors, Cytokine; Receptors, Tumor Necrosis Factor; Th2 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factors; TWEAK Receptor | 2013 |
Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis.
Topics: Animals; Anti-Inflammatory Agents; CD4 Lymphocyte Count; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunosuppressive Agents; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-17; Interleukin-6; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Phenotype; Sirolimus; Th17 Cells; Time Factors; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis.
Topics: Animals; Blood Vessels; Colitis; Colon; Corrosion Casting; Dextran Sulfate; Disease Models, Animal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Neovascularization, Pathologic; Trinitrobenzenesulfonic Acid | 2013 |
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice.
Topics: Animals; Central Nervous System Sensitization; Disease Models, Animal; Fibrosis; Inflammation; Injury Severity Score; Locomotion; Mice; Mice, Inbred C57BL; Mice, Knockout; Pancreatitis, Chronic; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; Visceral Pain | 2013 |
Dexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effect.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cells, Cultured; Colitis; Cytokines; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Immune System; Immunomodulation; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Spleen; Th17 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2013 |
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Signaling; Chemokines; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammation Mediators; Ion Channel Gating; Mice; Mice, Knockout; Pyrimidinones; Trinitrobenzenesulfonic Acid; TRPM Cation Channels; TRPV Cation Channels | 2013 |
The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.
Topics: Adenosine; Adult; Aged; Animals; Cell Hypoxia; Colitis; Disease Models, Animal; Enterochromaffin Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Response Elements; RNA, Messenger; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2013 |
Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Biopsy, Needle; Colitis; Cytokines; Disease Models, Animal; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Probiotics; Random Allocation; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.
Topics: Animals; Citrobacter rodentium; Colitis; Disease Models, Animal; Enterobacteriaceae Infections; Epithelial Cells; Ethanol; Fatty Acids, Volatile; Intestinal Mucosa; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, G-Protein-Coupled; Trinitrobenzenesulfonic Acid | 2013 |
Paradoxical regulation of ChAT and nNOS expression in animal models of Crohn's colitis and ulcerative colitis.
Topics: Acetylcholine; Animals; Blotting, Western; Choline O-Acetyltransferase; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Gene Expression Regulation, Enzymologic; Hydrogen Peroxide; Inflammation Mediators; Leupeptins; Male; Myenteric Plexus; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type I; Protein Multimerization; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Ubiquitin Thiolesterase | 2013 |
Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis.
Topics: Animals; Biomarkers; Colitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Feces; Humans; Inflammatory Bowel Diseases; Interleukin-6; Leukocyte L1 Antigen Complex; Male; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss | 2013 |
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Endotoxemia; Female; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunity, Innate; Immunity, Mucosal; Intestinal Mucosa; Mice; Permeability; Piperazines; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Pyridones; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation.
Topics: Acetylcholine; Acetylglucosamine; Adenocarcinoma; Animals; Cell Differentiation; Cell Line, Tumor; Colitis; Colon; Colorectal Neoplasms; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Gastrointestinal Diseases; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Humans; Hyperalgesia; Intestinal Mucosa; Male; Mast Cells; Morphine; Multidrug Resistance-Associated Proteins; Natriuretic Peptides; Organic Anion Transporters, Sodium-Independent; Peroxidase; Rats; Rats, Sprague-Dawley; Rats, Wistar; Restraint, Physical; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid; Visceral Pain | 2013 |
Evaluation of the usefulness of colonoscopy with mucosal biopsies in the follow-up of TNBS-induced colitis in rats.
Topics: Animals; Biopsy; Colitis; Colon; Colonoscopy; Disease Models, Animal; Intestinal Mucosa; Male; Rats; Trinitrobenzenesulfonic Acid | 2013 |
Recovery from TNBS-induced colitis leads to the resistance to recurrent colitis and an increased ratio of FOXP3 to CD3 mRNA.
Topics: Acute Disease; Animals; CD3 Complex; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Forkhead Transcription Factors; Gene Expression; Immune Tolerance; Mice; Mice, Inbred BALB C; Recurrence; RNA, Messenger; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2013 |
Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis.
Topics: Animals; Bacterial Translocation; Colitis; Colon; Disease Models, Animal; Endotoxins; Glucagon-Like Peptide 2; Male; Peroxidase; Random Allocation; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Interaction of Lactobacillus fermentum BGHI14 with rat colonic mucosa: implications for colitis induction.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Host-Pathogen Interactions; Intestinal Mucosa; Limosilactobacillus fermentum; Rats; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2013 |
Mitochondrial gene polymorphisms that protect mice from colitis.
Topics: Adenosine Triphosphate; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; DNA, Mitochondrial; Female; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Inbred NZB; Polymorphism, Genetic; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2013 |
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses.
Topics: Animals; Autoimmunity; Biomarkers; Cell Differentiation; Cell Proliferation; Cell Tracking; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Green Fluorescent Proteins; Inflammation Mediators; Intestinal Mucosa; Ki-67 Antigen; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Transgenic; Receptors, G-Protein-Coupled; T-Lymphocytes, Regulatory; Th2 Cells; Time Factors; Trinitrobenzenesulfonic Acid; Wound Healing | 2013 |
Penta-O-galloyl-β-D-glucose ameliorates inflammation by inhibiting MyD88/NF-κB and MyD88/MAPK signalling pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Hydrolyzable Tannins; Inflammation Mediators; Interleukin-1 Receptor-Associated Kinases; Macrophages, Peritoneal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myeloid Differentiation Factor 88; NF-kappa B; Phosphorylation; RNA Interference; Toll-Like Receptor 4; Transfection; Trinitrobenzenesulfonic Acid | 2013 |
AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antibodies, Monoclonal; Blotting, Western; Cattle; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Immunoglobulin G; Inflammation; Infliximab; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Synthesis and evaluation of mutual azo prodrug of 5-aminosalicylic acid linked to 2-phenylbenzoxazole-2-yl-5-acetic acid in ulcerative colitis.
Topics: Acetates; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzoxazoles; Colitis, Ulcerative; Disease Models, Animal; Female; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mesalamine; Prodrugs; Rats; Rats, Wistar; Salicylates; Spectrophotometry, Infrared; Trinitrobenzenesulfonic Acid | 2013 |
VEGF-A isoform modulation in an preclinical TNBS model of ulcerative colitis: protective effects of a VEGF164b therapy.
Topics: Animals; Blood Vessels; Cell Aggregation; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Disease Progression; HEK293 Cells; Humans; Leukocytes; Lymphatic Vessels; Mice; Organ Size; Protective Agents; Protein Isoforms; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A | 2013 |
Nilotinib-mediated mucosal healing in a rat model of colitis.
Topics: Animals; Apoptosis; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss; Wound Healing | 2013 |
Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri.
Topics: Animals; Artificial Gene Fusion; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation, Bacterial; Genes, Reporter; Histamine; Humans; Immunomodulation; Limosilactobacillus reuteri; Mice; Microbiota; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2013 |
Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice.
Topics: Aluminum; Aluminum Compounds; Animals; Cell Line; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Granuloma; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Male; Mice; Mice, Knockout; Phosphates; Trinitrobenzenesulfonic Acid; Wound Healing | 2014 |
Protective effects of Pogostemon cablin Bentham water extract on inflammatory cytokine expression in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; HT29 Cells; Humans; Intestinal Mucosa; Lamiaceae; Plant Components, Aerial; Plant Extracts; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; U937 Cells; Water | 2014 |
Genetically engineered immunomodulatory Streptococcus thermophilus strains producing antioxidant enzymes exhibit enhanced anti-inflammatory activities.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Immunologic Factors; Inflammation; Leukocytes, Mononuclear; Metabolic Engineering; Mice; Streptococcus thermophilus; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2014 |
Comparison of experimental mouse models of inflammatory bowel disease.
Topics: Acute Disease; Animals; Caspase 1; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-4; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2014 |
Aquaporin 3 and 8 are down-regulated in TNBS-induced rat colitis.
Topics: Animals; Aquaporin 3; Aquaporins; Colon; Crohn Disease; Disease Models, Animal; Down-Regulation; Female; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2014 |
Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Genetic Therapy; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-4; Interleukin-6; Mice; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme Activation; Glutathione; Isatin; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Microbial fingerprinting detects intestinal microbiota dysbiosis in Zebrafish models with chemically-induced enterocolitis.
Topics: Animals; Denaturing Gradient Gel Electrophoresis; Disease Models, Animal; DNA Fingerprinting; DNA, Bacterial; Dysbiosis; Enterocolitis; Female; Gastrointestinal Tract; Histocytochemistry; Humans; Male; Molecular Sequence Data; Sequence Analysis, DNA; Trinitrobenzenesulfonic Acid; Zebrafish | 2013 |
Beauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Depsipeptides; Disease Models, Animal; Down-Regulation; Female; Flow Cytometry; Gene Expression Regulation, Enzymologic; Inflammation; Interferon-gamma; Lymphocyte Activation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Intestinal upregulation of melanin-concentrating hormone in TNBS-induced enterocolitis in adult zebrafish.
Topics: Administration, Rectal; Animals; Cell Movement; Cytokines; Disease Models, Animal; Enterocolitis; Fish Proteins; Gene Expression Regulation; Humans; Hypothalamic Hormones; Intestinal Mucosa; Intestines; Male; Melanins; Microbiota; Peroxidase; Pituitary Hormones; Receptors, Pituitary Hormone; Survival Analysis; Trinitrobenzenesulfonic Acid; Vancomycin; Zebrafish | 2013 |
Effectiveness of a hydroxynaphthoquinone fraction from Arnebia euchroma in rats with experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Boraginaceae; Colitis, Ulcerative; Colon; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Gastrointestinal Agents; Goblet Cells; Inflammation Mediators; Male; Mesalamine; Naphthoquinones; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Plant Extracts; Rats; Rats, Wistar; Thymus Plant; Trinitrobenzenesulfonic Acid | 2014 |
ClC-3 chloride channel/antiporter defect contributes to inflammatory bowel disease in humans and mice.
Topics: Animals; Antiporters; Apoptosis; Blotting, Western; Chloride Channels; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Gastrointestinal Tract; Humans; In Situ Nick-End Labeling; Mice; Mice, Inbred C57BL; Mice, Knockout; Paneth Cells; Trinitrobenzenesulfonic Acid | 2014 |
Induction of murine TNBS colitis is strictly controlled by a modified method using continuous inhalation anesthesia with sevoflurane.
Topics: Anesthesia, Inhalation; Anesthetics; Anesthetics, Inhalation; Animals; Biomarkers; Colitis; Cytokines; Disease Models, Animal; Drug Administration Schedule; Enema; Ethanol; Female; Injections, Intraperitoneal; Methyl Ethers; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Sevoflurane; Trinitrobenzenesulfonic Acid | 2014 |
Role of metallothioneins as danger signals in the pathogenesis of colitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antibodies; Apoptosis; Biopsy; Case-Control Studies; Chemotaxis, Leukocyte; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; HT29 Cells; Humans; Macrophages; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Necrosis; Severity of Illness Index; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Young Adult | 2014 |
Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.
Topics: Animals; Body Weight; Colitis; Colon; Disease Models, Animal; Gene Knockdown Techniques; Male; Organ Size; Phosphorylation; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reference Values; RNA Interference; Spleen; Trinitrobenzenesulfonic Acid; Urocortins | 2014 |
Analgesic effect of minocycline in rat model of inflammation-induced visceral pain.
Topics: Analgesics; Animals; Behavior, Animal; Colitis; Colon; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mechanotransduction, Cellular; Microglia; Minocycline; Pain Perception; Pressure; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Visceral Pain | 2014 |
Effect of glucans from Caripia montagnei mushroom on TNBS-induced colitis.
Topics: Agaricales; Alkaline Phosphatase; Animals; Catalase; Colitis; Cytokines; Disease Models, Animal; Enzyme Activation; Glucans; Intestinal Mucosa; Male; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Peroxidase; Rats; Spectroscopy, Fourier Transform Infrared; Trinitrobenzenesulfonic Acid | 2014 |
Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Crohn's disease in mice.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Biomarkers; Capsules; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Particle Size; Peroxidase; Polylysine; Solubility; Technology, Pharmaceutical; Thalidomide; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.
Topics: Animals; Cabergoline; Colitis; Dextran Sulfate; Disease Models, Animal; Dopamine Agonists; Ergolines; Forkhead Transcription Factors; Immunity, Mucosal; Inflammation; Interleukins; Mice; Mice, Inbred BALB C; Prolactin; Stress, Psychological; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.
Topics: Animals; Cetirizine; Colitis; Colonoscopy; Convalescence; Disease Models, Animal; Histamine; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Hypersensitivity; Indoles; Intestinal Mucosa; Male; Mast Cells; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4; Regeneration; Trinitrobenzenesulfonic Acid | 2014 |
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Aged; Animals; Colitis; Colitis, Ulcerative; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Genotype; Humans; Ileitis; Immunity, Mucosal; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nod2 Signaling Adaptor Protein; Peptide Transporter 1; Polymorphism, Single Nucleotide; RNA, Messenger; Symporters; Tissue Culture Techniques; Trinitrobenzenesulfonic Acid; Young Adult | 2014 |
Neuron-glial communication mediated by TNF-α and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Behavior, Animal; Cell Communication; Cell Surface Extensions; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; Gap Junctions; Hyperalgesia; Inflammation Mediators; Male; Neuroglia; Neurons; Pain Threshold; Pressure; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.
Topics: Animals; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Enzyme Activation; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Interleukin-13; Mice; Mice, Inbred BALB C; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Trinitrobenzenesulfonic Acid | 2014 |
Intervention effects of QRZSLXF, a Chinese medicinal herb recipe, on the DOR-β-arrestin1-Bcl2 signal transduction pathway in a rat model of ulcerative colitis.
Topics: Animals; Arrestins; beta-Arrestins; Colitis, Ulcerative; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Male; Muscle Proteins; Proto-Oncogene Proteins c-bcl-2; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid | 2014 |
DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat.
Topics: Animals; Colitis; Dietary Fats; Dinitrofluorobenzene; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2014 |
The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Inhibitory Concentration 50; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Spleen; STAT3 Transcription Factor; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Preparation and evaluation of colon adhesive pellets of 5-aminosalicylic acid.
Topics: Acrylic Resins; Adhesiveness; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Cellulose; Chemistry, Pharmaceutical; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Carriers; Excipients; Kinetics; Male; Mesalamine; Polymethacrylic Acids; Rats, Sprague-Dawley; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2014 |
Role of gut microbiota in a zebrafish model with chemically induced enterocolitis involving toll-like receptor signaling pathways.
Topics: Animals; Disease Models, Animal; Enterocolitis; Gastrointestinal Tract; Inflammatory Bowel Diseases; Microbiota; Signal Transduction; Toll-Like Receptors; Trinitrobenzenesulfonic Acid; Zebrafish; Zebrafish Proteins | 2014 |
Intestinal anti-inflammatory effects of oligosaccharides derived from lactulose in the trinitrobenzenesulfonic acid model of rat colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Disease Models, Animal; Female; Humans; Interleukins; Intestines; Lactulose; Microbiota; Oligosaccharides; Prebiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2014 |
Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.
Topics: Animals; Cell Line; Colitis; Collagen Type I; Colon; Disease Models, Animal; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Insulin-Like Growth Factor I; Male; MAP Kinase Kinase Kinases; Mice; Mutation; Phosphorylation; Rats, Sprague-Dawley; Receptor, IGF Type 1; Resveratrol; RNA Interference; RNA, Messenger; Signal Transduction; Sirtuin 1; Stilbenes; Transfection; Trinitrobenzenesulfonic Acid | 2014 |
Pyruvate kinase M2 regulates apoptosis of intestinal epithelial cells in Crohn's disease.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Carrier Proteins; Case-Control Studies; Colon; Crohn Disease; Disease Models, Animal; Epithelial Cells; Female; HT29 Cells; Humans; Inflammation Mediators; Intestinal Mucosa; Membrane Proteins; Mice; Mice, Inbred BALB C; Prospective Studies; Pyruvate Kinase; RNA Interference; Signal Transduction; Thyroid Hormone-Binding Proteins; Thyroid Hormones; Time Factors; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Antioxidants; Apoptosis; Benzimidazoles; Benzoates; Colitis; Colon; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Immunohistochemistry; Inflammation; Inflammatory Bowel Diseases; Lipid Peroxidation; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Telmisartan; Trinitrobenzenesulfonic Acid | 2014 |
Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction.
Topics: Animals; Caco-2 Cells; Catechols; Colitis; Diarylheptanoids; Disease Models, Animal; ErbB Receptors; Gene Expression Regulation; Heme Oxygenase-1; Humans; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase 3; Occludin; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; tert-Butylhydroperoxide; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2014 |
Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Enteroendocrine Cells; Gastrointestinal Agents; Gene Expression Regulation; Glucagon-Like Peptide 2; Glucagon-Like Peptide-2 Receptor; Hep G2 Cells; Hepatectomy; HT29 Cells; Humans; Jurkat Cells; Liver; Liver Regeneration; Mice; Mice, Inbred C57BL; Peptide Fragments; Rats; Receptors, Glucagon; Recombinant Proteins; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
A mixed formulation of lactic acid bacteria inhibits trinitrobenzene-sulfonic-acid-induced inflammatory changes of the colon tissue in mice.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Colon; Disease Models, Animal; Lactobacillales; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Probiotics; Trinitrobenzenesulfonic Acid | 2014 |
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colitis; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gastrointestinal Motility; Inflammation Mediators; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Synthase Type II; Phosphorylation; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
Inhibition of the interleukin-23/interleukin-17 pathway by anti-interleukin-23p19 monoclonal antibody attenuates 2,4,6-trinitrobenzene sulfonic acid-induced Crohn's disease in rats.
Topics: Animals; Antibodies, Monoclonal; Crohn Disease; Disease Models, Animal; Interleukin-17; Interleukin-23; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Rats; Rats, Sprague-Dawley; RNA, Messenger; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2014 |
Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Interleukin-1beta; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Oenothera biennis; Plant Extracts; Polyphenols; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Immunoglobulin A; Inflammation; Interleukin-10; Interleukin-6; Lactococcus lactis; Mice; Mice, Inbred C57BL; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2014 |
Preventive effects of Escherichia coli strain Nissle 1917 with different courses and different doses on intestinal inflammation in murine model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Escherichia coli; Female; Ileum; Interleukin-10; Intestinal Mucosa; Peroxidase; Probiotics; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2014 |
Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis.
Topics: Animals; Astragalus propinquus; Body Weight; Colitis; Colon; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Interleukin-1beta; Male; Nerve Tissue Proteins; NFATC Transcription Factors; Polysaccharides; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Anti-inflammatory action of a novel orally available peptide 317 in mouse models of inflammatory bowel diseases.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Animals; Anti-Inflammatory Agents; Biological Availability; Case-Control Studies; Colitis, Ulcerative; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred BALB C; Middle Aged; Peptides, Cyclic; Real-Time Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Young Adult | 2014 |
Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Enkephalins; Inflammation; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred BALB C; Mustard Plant; Plant Oils; Trinitrobenzenesulfonic Acid | 2014 |
Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Butyric Acid; Carnitine; Colitis; Colon; Combined Modality Therapy; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Lacticaseibacillus casei; Male; Oxidative Stress; Probiotics; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis.
Topics: Animals; Colitis, Ulcerative; Colon; Dextran Sulfate; Disease Models, Animal; Female; Inflammation Mediators; Interleukin-10; Interleukin-8; Intestinal Mucosa; Male; Moxibustion; Rats, Sprague-Dawley; Time Factors; Toll-Like Receptor 9; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Wound Healing | 2014 |
Oridonin's therapeutic effect: suppressing Th1/Th17 simultaneously in a mouse model of Crohn's disease.
Topics: Animals; Apoptosis; Cells, Cultured; Crohn Disease; Disease Models, Animal; Diterpenes, Kaurane; Interferon-gamma; Interleukin-17; Male; Mice, Inbred BALB C; NF-kappa B; Phytotherapy; Spleen; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Divergent influence of microRNA-21 deletion on murine colitis phenotypes.
Topics: Animals; Biomarkers; Blotting, Western; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Deletion; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Oligonucleotide Array Sequence Analysis; Phenotype; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2014 |
Mitigation of colitis with NovaSil clay therapy.
Topics: Aluminum Silicates; Animals; Anti-Inflammatory Agents; Bacteria; Clay; Colitis; Colon; Crystallography, X-Ray; Cytokines; Disease Models, Animal; Feces; Female; Gastrointestinal Agents; Inflammation Mediators; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Powder Diffraction; Ribotyping; Silicates; Time Factors; Trinitrobenzenesulfonic Acid; Weight Gain | 2015 |
Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm.
Topics: Animals; Blotting, Western; Colitis; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Flavonoids; Flow Cytometry; Immunologic Factors; Inflammation Mediators; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Effectiveness of sildenafil and U-74389G in a rat model of colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Malondialdehyde; Phosphodiesterase 5 Inhibitors; Piperazines; Pregnatrienes; Purines; Random Allocation; Rats, Wistar; Sildenafil Citrate; Sulfones; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.
Topics: Animals; Case-Control Studies; Cell Line; Claudin-1; Colitis; Colon; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Genetic Predisposition to Disease; Humans; Inflammatory Bowel Diseases; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Permeability; Phenotype; Repressor Proteins; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
Homocysteine promotes intestinal fibrosis in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Collagen Type I; Collagen Type III; Colon; Cytokines; Disease Models, Animal; Ethanol; Fibrosis; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Vasoactive intestinal peptide-deficient mice exhibit reduced pathology in trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Cell Proliferation; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; RNA, Messenger; T-Lymphocytes; Time Factors; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2015 |
The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mice; Microcirculation; Neovascularization, Pathologic; Receptors, Neurotensin; Trinitrobenzenesulfonic Acid; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Inflammation Mediators; Male; Mesalamine; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-12; Intestinal Mucosa; Prebiotics; Random Allocation; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Sulfasalazine; Toll-Like Receptor 2; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Trisaccharides | 2015 |
PGRN protects against colitis progression in mice in an IL-10 and TNFR2 dependent manner.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bone Marrow; CD4-Positive T-Lymphocytes; Dextran Sulfate; Disease Models, Animal; Disease Progression; Gene Expression Regulation; Granulins; Humans; Inflammatory Bowel Diseases; Intercellular Signaling Peptides and Proteins; Interleukin-10; Mice; Mice, Knockout; Progranulins; Receptors, Tumor Necrosis Factor, Type II; Recombinant Proteins; Signal Transduction; Transplantation Chimera; Trinitrobenzenesulfonic Acid | 2014 |
Milk fermented with a 15-lipoxygenase-1-producing Lactococcus lactis alleviates symptoms of colitis in a murine model.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Colitis; Disease Models, Animal; Female; Fermentation; Lactococcus lactis; Mice, Inbred BALB C; Milk; Trinitrobenzenesulfonic Acid | 2015 |
Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Diterpenes; Female; Freezing Reaction, Cataleptic; Ganglia, Spinal; Grooming; Neurons, Afferent; Pain; Peroxidase; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Urethra; Urinary Bladder | 2015 |
Alleviated mucosal and neuronal damage in a rat model of Crohn's disease.
Topics: Animals; Colitis; Colon; Crohn Disease; Disease Models, Animal; Heme Oxygenase (Decyclizing); Intestinal Mucosa; Male; Myenteric Plexus; Rats, Sprague-Dawley; Recurrence; Remission Induction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2014 |
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Topics: Animals; CD40 Antigens; Chemokine CXCL5; Colitis; Dextran Sulfate; Dipeptides; Disease Models, Animal; Fibrinolysin; Inflammation; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Myeloid Cells; Neutrophils; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Comparison of noncontrast MRI magnetization transfer and T2 -Weighted signal intensity ratios for detection of bowel wall fibrosis in a Crohn's disease animal model.
Topics: Animals; Collagen; Colon; Crohn Disease; Disease Models, Animal; Fibrosis; Inflammation; Intestinal Mucosa; Intestines; Magnetic Resonance Imaging; Rats; Rats, Inbred Lew; ROC Curve; Sensitivity and Specificity; Signal Processing, Computer-Assisted; Trinitrobenzenesulfonic Acid | 2015 |
Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice.
Topics: Acupuncture Points; Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Electroacupuncture; Immunohistochemistry; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-1beta; Male; Malondialdehyde; Mice; Nitric Oxide Synthase Type II; Peroxidase; Random Allocation; Trinitrobenzenesulfonic Acid | 2014 |
Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis.
Topics: Administration, Oral; Animals; Colitis; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1; Immunoenzyme Techniques; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mucous Membrane; Piperazines; Prolyl-Hydroxylase Inhibitors; Pyridones; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Colitis; Colon; Disease Models, Animal; Fibrosis; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Tight Junction Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2014 |
Bifidobacterium infantis attenuates colitis by regulating T cell subset responses.
Topics: Animals; Bifidobacterium; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Mice, Inbred BALB C; Probiotics; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Early inflammatory damage to intestinal neurons occurs via inducible nitric oxide synthase.
Topics: Animals; Cell Line; Coculture Techniques; Colitis; Disease Models, Animal; Enteric Nervous System; Female; Hyperplasia; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C3H; Muscle, Smooth; Neuroimmunomodulation; Neurons; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hyperalgesia; Inflammation Mediators; Irritable Bowel Syndrome; Male; Middle Aged; Pain Threshold; Peroxidase; Pilot Projects; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide; Visceral Pain; Weight Loss; Young Adult | 2015 |
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Topics: Abdominal Fat; Adipocytes, White; Adipokines; Animals; Case-Control Studies; Cells, Cultured; Colitis; Colon; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Inflammation Mediators; Male; Mice, Inbred C57BL; Obesity; Receptors, Adiponectin; RNA Interference; RNA, Messenger; Severity of Illness Index; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid | 2015 |
Prostaglandin E₂ and polyenylphosphatidylcholine protect against intestinal fibrosis and regulate myofibroblast function.
Topics: Animals; Biomarkers; Cytokines; Dinoprostone; Disease Models, Animal; Female; Fibrosis; Gene Expression; Humans; Immunoenzyme Techniques; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Myofibroblasts; Phosphatidylcholines; Real-Time Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2015 |
Adrenergic signaling mediates mechanical hyperalgesia through activation of P2X3 receptors in primary sensory neurons of rats with chronic pancreatitis.
Topics: Adenosine Triphosphate; Adrenergic beta-2 Receptor Antagonists; Animals; Behavior, Animal; Calcium Signaling; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Motor Activity; Norepinephrine; Pain Threshold; Pancreas; Pancreatitis, Chronic; Protein Kinase Inhibitors; Purinergic P2X Receptor Antagonists; Rats, Sprague-Dawley; Receptor Cross-Talk; Receptors, Adrenergic, beta-2; Receptors, Purinergic P2X3; Sensory Receptor Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2015 |
Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Biomarkers; Colitis; Colon; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Organ Size; Pilot Projects; Random Allocation; Rats, Wistar; Solubility; Trinitrobenzenesulfonic Acid | 2015 |
[Experimental study of adipose-derived mesenchymal stem cells in the treatment of Crohn's disease].
Topics: Adipocytes; Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Down-Regulation; Female; Inflammatory Bowel Diseases; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Sensory and inflammatory colonic changes induced by vincristine in distinct rat models of colitis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colitis; Colon; Disease Models, Animal; Drug Interactions; Male; Mustard Plant; Pain Threshold; Plant Oils; Rats; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Vincristine | 2015 |
Exogenous carcinoembryonic antigen-related cell adhesion molecule 1 suppresses 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in mice.
Topics: Animals; Apoptosis; Carcinoembryonic Antigen; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Female; Genetic Therapy; Mice, Inbred BALB C; Random Allocation; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2015 |
Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice.
Topics: Animals; Antigens, Surface; Apoptosis; Cell Line; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Milk Proteins; Protective Agents; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 2015 |
Ablation of tumor necrosis factor is associated with decreased inflammation and alterations of the microbiota in a mouse model of inflammatory bowel disease.
Topics: Animals; Bacteria; Colitis, Ulcerative; Disease Models, Animal; DNA, Bacterial; Feces; Female; Humans; Mice; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colectomy; Colitis; Disease Models, Animal; Male; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesives; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
Vitamin D/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis.
Topics: Animals; Apoptosis; Case-Control Studies; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Permeability; Receptors, Calcitriol; Signal Transduction; Trinitrobenzenesulfonic Acid; Vitamin D | 2015 |
Royal Jelly and its dual role in TNBS colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Cyclooxygenase 2; Disease Models, Animal; Fatty Acids; Female; Functional Food; Glutathione; Glutathione Peroxidase; Humans; Mice; NF-kappa B; Trinitrobenzenesulfonic Acid | 2015 |
P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.
Topics: Adenosine Triphosphate; Animals; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Phenols; Polycyclic Compounds; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Trinitrobenzenesulfonic Acid | 2015 |
Effect of 3-aminobenzamide on perforation an experimental colitis model.
Topics: Animals; Benzamides; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Intestinal Perforation; Lipid Peroxidation; Male; Malondialdehyde; Pressure; Rats; Rats, Wistar; Rupture; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Validation of a modified model of TNBS-induced colitis in rats. How to induce a chemical colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Instillation, Drug; Male; Rats; Rats, Wistar; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2015 |
Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Feces; Feeding Behavior; Food Preferences; Gastrointestinal Agents; Immunity, Mucosal; Inflammation Mediators; Interleukin-1beta; Interleukin-4; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Medicine, Chinese Traditional; Motor Activity; Pain Threshold; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Galactans; Male; Mannans; Mesalamine; Pectins; Plant Gums; Prodrugs; Rats; Tablets; Trinitrobenzenesulfonic Acid | 2015 |
SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Colon; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; HCT116 Cells; Humans; Immediate-Early Proteins; Intestinal Mucosa; MAP Kinase Kinase 1; Mice, Inbred BALB C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rabbits; RNA Interference; Signal Transduction; Time Factors; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2015 |
Serum serotonin reduced the expression of hepatic transporter Mrp2 and P-gp via regulating nuclear receptor CAR in PI-IBS rats.
Topics: 5-Hydroxytryptophan; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Colon; Constitutive Androstane Receptor; Disease Models, Animal; Enterochromaffin Cells; Fenclonine; Irritable Bowel Syndrome; Liver; Male; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
Combined Therapy with Rheum tanguticum Polysaccharide and Low-dose 5-ASA Ameliorates TNBS-Induced Colitis in Rats by Suppression of NF-κB.
Topics: Animals; Body Weight; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Drug Therapy, Combination; Male; NF-kappa B; Nitric Oxide Synthase Type II; Polysaccharides; Rats; Rats, Sprague-Dawley; Rheum; Trinitrobenzenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Rivaroxaban Induces Mucosal Healing in a Rat Model of Trinitrobenzene Sulfonic Acid-Induced Colitis.
Topics: Animals; Colitis; Disease Models, Animal; Factor Xa Inhibitors; Female; Immunosuppressive Agents; Intestinal Mucosa; Malondialdehyde; Methylprednisolone; Rats; Rats, Wistar; Rivaroxaban; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, Myelomonocytic; Cell Movement; Colitis; Colon; Disease Models, Animal; Eosinophils; Female; Glutathione Transferase; Helminth Proteins; Immunization; Interleukin-13; Interleukin-5; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Schistosoma mansoni; Schistosomiasis mansoni; Sialic Acid Binding Immunoglobulin-like Lectins; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2016 |
Adipose-Derived Mesenchymal Stem Cells Ameliorate Ulcerative Colitis Through miR-1236 Negatively Regulating the Expression of Retinoid-Related Orphan Receptor Gamma.
Topics: 3' Untranslated Regions; Adipose Tissue; Animals; Cells, Cultured; Colitis, Ulcerative; Disease Models, Animal; Gene Expression Regulation; Injections, Intravenous; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; MicroRNAs; Nuclear Receptor Subfamily 1, Group F, Member 3; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis.
Topics: Aconitine; Aconitum; Alkaloids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Disease Models, Animal; Diterpenes; Epithelial Cells; Interferon-gamma; Male; Mice; Mice, Inbred C57BL; Plant Extracts; RNA, Messenger; Trinitrobenzenesulfonic Acid; Weight Loss | 2015 |
Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages.
Topics: Animals; Cell Line; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Intestinal Mucosa; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 1; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway.
Topics: Animals; Antidepressive Agents; Colitis; Colon; Crohn Disease; Depression; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hippocampus; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome.
Topics: Aged; Aged, 80 and over; Anilides; Animals; Antibodies, Neutralizing; Blotting, Western; Burning Mouth Syndrome; Cinnamates; Disease Models, Animal; Female; Glial Cell Line-Derived Neurotrophic Factor Receptors; Glossalgia; Hot Temperature; Humans; Hyperalgesia; Male; Mice; Middle Aged; Nerve Tissue Proteins; Neurons; Patch-Clamp Techniques; Real-Time Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Tongue; Trigeminal Ganglion; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2015 |
Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Biomarkers; Capsules; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Gelatin; Gene Expression Regulation; HCT116 Cells; Humans; Inflammation Mediators; Male; Mice; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Stilbenes; Technology, Pharmaceutical; Transfection; Trinitrobenzenesulfonic Acid | 2015 |
Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis.
Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Chromones; Colitis; Disease Models, Animal; Enzyme Inhibitors; Male; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Chromatography, High Pressure Liquid; Colitis; Colon; Cyclosporine; Cytokines; Disease Models, Animal; Half-Life; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.
Topics: Animals; Clodronic Acid; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Flow Cytometry; Inflammation; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2016 |
Neuroprotective Potential of Mesenchymal Stem Cell-Based Therapy in Acute Stages of TNBS-Induced Colitis in Guinea-Pigs.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Flow Cytometry; Guinea Pigs; Humans; Male; Mesenchymal Stem Cell Transplantation; Microscopy, Confocal; Myenteric Plexus; Neurons; Trinitrobenzenesulfonic Acid | 2015 |
Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Adhesion; Caco-2 Cells; Cells, Cultured; Colitis; Cultured Milk Products; Disease Models, Animal; Gastrointestinal Tract; Humans; Interleukin-10; Lactobacillus helveticus; Leukocytes, Mononuclear; Membrane Glycoproteins; Mice; Molecular Typing; Mongolia; Probiotics; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity.
Topics: Adaptive Immunity; Afferent Pathways; Animals; Colitis; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Interleukin-2; Irritable Bowel Syndrome; Mice; NAV1.7 Voltage-Gated Sodium Channel; Neurons, Afferent; Peroxidase; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channel Blockers; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Visceral Pain | 2016 |
Extracellular Vesicles Derived from Bone Marrow Mesenchymal Stem Cells Protect against Experimental Colitis via Attenuating Colon Inflammation, Oxidative Stress and Apoptosis.
Topics: Animals; Apoptosis; Cells, Cultured; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Extracellular Vesicles; Inflammation; Male; Mesenchymal Stem Cells; Oxidative Stress; Paracrine Communication; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn's Disease Mouse Model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Colitis; Crohn Disease; Disease Models, Animal; Female; Gene Expression; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Spleen; Th1 Cells; Th1-Th2 Balance; Th2 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Elevated H2 O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel.
Topics: Abdominal Pain; Acetanilides; Acetylcysteine; Administration, Intravenous; Animals; Colitis; Colon; Disease Models, Animal; Free Radical Scavengers; Hydrogen Peroxide; Hyperalgesia; Male; Pain Threshold; Purines; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation; Visceral Pain | 2016 |
Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Abdominal Pain; Adrenergic Antagonists; Age Factors; Animals; Animals, Newborn; Carrier Proteins; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Colon; Disease Models, Animal; Gastric Fundus; Intracellular Signaling Peptides and Proteins; Male; Matrix Metalloproteinase 9; Nerve Growth Factor; Norepinephrine; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Proteolysis; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
Topics: Animals; Colitis; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Histamine; Histidine; Histidine Decarboxylase; Immunomodulation; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Limosilactobacillus reuteri; Mice; Positron-Emission Tomography; Probiotics; Receptors, Histamine H2; Serum Amyloid A Protein; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
AT1R blocker losartan attenuates intestinal epithelial cell apoptosis in a mouse model of Crohn's disease.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Crohn Disease; Cytokines; Disease Models, Animal; Epithelial Cells; Inflammation Mediators; Intestinal Mucosa; Intestines; Losartan; Male; Mice, Inbred C57BL; Permeability; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Cell Line; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peroxidase; Piperidones; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2016 |
Colitis-induced bladder afferent neuronal activation is regulated by BDNF through PLCγ pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Colitis; CREB-Binding Protein; Disease Models, Animal; Ganglia, Spinal; Male; Mice, Knockout; Neurons; Phospholipase C gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; Up-Regulation; Urinary Bladder | 2016 |
Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis.
Topics: Adipose Tissue; Animals; Bone Marrow Cells; Cell Differentiation; Cholinergic Neurons; Colitis; Disease Models, Animal; Female; Guinea Pigs; Humans; Hyaluronan Receptors; Immunohistochemistry; Immunophenotyping; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microscopy, Confocal; Myenteric Plexus; Transforming Growth Factor beta1; Transplantation, Homologous; Trinitrobenzenesulfonic Acid | 2015 |
Oridonin derivative ameliorates experimental colitis by inhibiting activated T-cells and translocation of nuclear factor-kappa B.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cytokines; Disease Models, Animal; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastrointestinal Agents; Immunosuppressive Agents; Inflammation Mediators; Intestinal Mucosa; Lymphocyte Activation; Male; Mice, Inbred BALB C; NF-kappa B; Signal Transduction; Spleen; T-Lymphocyte Subsets; Th1 Cells; Th17 Cells; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2016 |
1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Inflammation; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Toll-Like Receptor 9; Trinitrobenzenesulfonic Acid; Vitamin D | 2015 |
Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology.
Topics: Administration, Oral; Animals; Cadmium; Colitis; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Female; Immune System; Immunomodulation; Intestinal Mucosa; Lead; Metals, Heavy; Mice; Salmonella Infections; Salmonella typhimurium; Time Factors; Trinitrobenzenesulfonic Acid | 2016 |
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.
Topics: Animals; Colitis; Colon; Dipeptides; Disease Models, Animal; Female; Guinea Pigs; Hyperalgesia; Male; Receptors, Neurokinin-2; Sex Characteristics; Thiophenes; Trinitrobenzenesulfonic Acid; Visceral Pain | 2016 |
Dysbiosis of the fecal microbiota in the TNBS-induced Crohn's disease mouse model.
Topics: Animals; Crohn Disease; Disease Models, Animal; DNA, Bacterial; Dysbiosis; Feces; Gastrointestinal Microbiome; Intestines; Male; Mice; Mice, Inbred BALB C; RNA, Ribosomal, 16S; Sequence Analysis, DNA; Trinitrobenzenesulfonic Acid | 2016 |
Rhenium-coated glass beads for intracolonic administration attenuate TNBS-induced colitis in mice: Proof-of-Concept Study.
Topics: Animals; Anti-Inflammatory Agents; Biocompatible Materials; Colitis, Ulcerative; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Glass; Mice; Mice, Inbred BALB C; Rhenium; Trinitrobenzenesulfonic Acid | 2015 |
Moxibustion regulates inflammatory mediators and colonic mucosal barrier in ulcerative colitis rats.
Topics: Acupuncture Points; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Down-Regulation; Female; Inflammation Mediators; Intestinal Absorption; Intestinal Mucosa; Male; Moxibustion; Occludin; p38 Mitogen-Activated Protein Kinases; Permeability; Phosphorylation; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2016 |
The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Cactaceae; Colitis; Colon; Cytokines; Disease Models, Animal; Ethanol; Flavonoids; Fruit; Gene Expression; Irritable Bowel Syndrome; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Polyphenols; Trinitrobenzenesulfonic Acid | 2016 |
Experimental and Pathalogical study of Pistacia atlantica, butyrate, Lactobacillus casei and their combination on rat ulcerative colitis model.
Topics: Animals; Butyrates; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Lacticaseibacillus casei; Male; Oxidative Stress; Peroxidase; Pistacia; Plant Extracts; Probiotics; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2016 |
Histological and immunohistochemical effects of L-arginine and silymarin on TNBS-induced inflammatory bowel disease in rats.
Topics: Animals; Antioxidants; Arginine; Disease Models, Animal; Immunohistochemistry; Inflammatory Bowel Diseases; Male; Random Allocation; Rats; Silymarin; Trinitrobenzenesulfonic Acid | 2016 |
Ozanimod (RPC1063) is a potent sphingosine-1-phosphate receptor-1 (S1P1 ) and receptor-5 (S1P5 ) agonist with autoimmune disease-modifying activity.
Topics: Animals; Autoimmune Diseases; Disease Models, Animal; Female; Indans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Mice, SCID; Myelin-Oligodendrocyte Glycoprotein; Oxadiazoles; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Trinitrobenzenesulfonic Acid | 2016 |
Methods of Inducing Inflammatory Bowel Disease in Mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2016 |
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Topics: Alcohol Oxidoreductases; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Colitis; Disease Models, Animal; Epithelial Cells; Humans; Intestinal Mucosa; Intestines; Mice; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches.
Topics: Animals; Anti-Inflammatory Agents; Astragalus propinquus; Colitis; Colon; Cytokines; Disease Models, Animal; Inflammation Mediators; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Peyer's Patches; Phosphorylation; Phytotherapy; Plants, Medicinal; Polysaccharides; Rats, Sprague-Dawley; STAT5 Transcription Factor; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2016 |
Pro-inflammatory miR-223 mediates the cross-talk between the IL23 pathway and the intestinal barrier in inflammatory bowel disease.
Topics: Animals; Antagomirs; Caco-2 Cells; Cell Line; Claudins; Disease Models, Animal; Gene Expression Profiling; Gene Expression Regulation; Humans; Inflammatory Bowel Diseases; Interleukin-23; Mice; MicroRNAs; Oligonucleotide Array Sequence Analysis; Oligonucleotides; Signal Transduction; Trinitrobenzenesulfonic Acid | 2016 |
Insight into the pharmacokinetic behavior of tanshinone IIA in the treatment of Crohn's disease: comparative data for tanshinone IIA and its two glucuronidated metabolites in normal and recurrent colitis models after oral administration.
Topics: Abietanes; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Disease Models, Animal; Glucuronosyltransferase; Mice; Trinitrobenzenesulfonic Acid; UDP-Glucuronosyltransferase 1A9 | 2017 |
Hypothalamic paraventricular nucleus stimulation reduces intestinal injury in rats with ulcerative colitis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Colitis, Ulcerative; Colon; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glutamic Acid; Inflammation Mediators; Oxidative Stress; Paraventricular Hypothalamic Nucleus; Rats, Sprague-Dawley; Signal Transduction; Solitary Nucleus; Trinitrobenzenesulfonic Acid; Vagus Nerve | 2016 |
Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response.
Topics: Animals; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Forkhead Transcription Factors; Hot Temperature; Humans; Immunosuppression Therapy; Immunotherapy; Inflammation Mediators; Intestinal Mucosa; Lacticaseibacillus casei; Male; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid | 2016 |
Comparison of Adipose-Derived and Bone Marrow Mesenchymal Stromal Cells in a Murine Model of Crohn's Disease.
Topics: Adipose Tissue; Animals; Bone Marrow Cells; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Injections, Intraperitoneal; Interleukin-10; Interleukin-12; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2017 |
Anti-inflammatory effects of Citrus sinensis L., Citrus paradisi L. and their combinations.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; C-Reactive Protein; Citrus paradisi; Citrus sinensis; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fruit; Fruit and Vegetable Juices; Glutathione; Inflammation Mediators; Male; Oxidative Stress; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2016 |
Tauroursodeoxycholate improves 2,4,6-trinitrobenzenesulfonic acid-induced experimental acute ulcerative colitis in mice.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Inflammatory Agents; Body Weight; Colitis, Ulcerative; Colon; Disease Models, Animal; Humans; Interferon-gamma; Interleukin-1beta; Male; Mice; Mice, Inbred BALB C; Peroxidase; Taurochenodeoxycholic Acid; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Bacteria; Biotransformation; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Gastrointestinal Agents; Gastrointestinal Microbiome; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; NF-kappa B; Signal Transduction; Spleen; T-Lymphocytes, Regulatory; Th17 Cells; Time Factors; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
Murine Trinitrobenzoic Acid-Induced Colitis as a Model of Crohn's Disease.
Topics: Adaptive Immunity; Animals; Colitis; Crohn Disease; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Immunity, Innate; Mice; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2016 |
VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Body Size; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Epithelial Cells; Female; Humans; Male; Mice, Inbred BALB C; NF-kappa B; Pregnadienediols; Trinitrobenzenesulfonic Acid | 2016 |
Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Colitis; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Female; Glutathione; Inflammation Mediators; Lavandula; Matrix Metalloproteinase 9; Methanol; Mice, Inbred BALB C; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Rats, Wistar; Solvents; Trinitrobenzenesulfonic Acid | 2016 |
Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.
Topics: Animals; Apoptosis; Blotting, Western; Colitis; Colon; Constriction, Pathologic; Crohn Disease; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Intestinal Obstruction; Male; Matrix Metalloproteinase 9; Microscopy, Electron, Transmission; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Trinitrobenzenesulfonic Acid | 2016 |
Curcumin improves regulatory T cells in gut-associated lymphoid tissue of colitis mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Colon; Curcumin; Cytokines; Dendritic Cells; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Ethanol; Humans; Intestinal Mucosa; Lymphoid Tissue; Male; Mesalamine; Mice; Mice, Inbred C57BL; Random Allocation; Signal Transduction; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2016 |
FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Female; Gastrointestinal Microbiome; Humans; Inflammation; Limosilactobacillus reuteri; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Mutagenesis, Insertional; Peptide Synthases; Probiotics; Tetrahydrofolates; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Colonic mucosal N-methyl-D-aspartate receptor mediated visceral hypersensitivity in a mouse model of irritable bowel syndrome.
Topics: Ammonia; Animals; Colon; Dilatation; Disease Models, Animal; Feces; Glutamic Acid; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Mice, Inbred C57BL; Pain Threshold; Receptors, N-Methyl-D-Aspartate; Reflex; Trinitrobenzenesulfonic Acid; Viscera | 2016 |
Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis.
Topics: Animals; Benzamides; Biomarkers; Body Weight; Chromogranin A; Colitis; Cyclohexanones; Disease Models, Animal; Endocrine Cells; Gene Expression; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; NF-kappa B; Piperidones; Rats; Serotonin; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2016 |
Transplantation of a bacterial consortium ameliorates trinitrobenzenesulfonic acid-induced colitis and intestinal dysbiosis in rats.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Inflammatory Bowel Diseases; Intestines; Mice; Microbial Consortia; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2016 |
Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Immunologic Factors; Inflammation Mediators; Macrophages; Mass Spectrometry; Mice; Microfilament Proteins; Mucins; Nitric Oxide Synthase Type II; Nitrites; Phenols; Phytotherapy; Plant Bark; Plant Extracts; Plants, Medicinal; Rats, Wistar; RAW 264.7 Cells; Solvents; Terminalia; Trinitrobenzenesulfonic Acid | 2016 |
Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis.
Topics: Animals; CD11b Antigen; CD4-Positive T-Lymphocytes; Chemokine CCL5; Chemokines; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Homeodomain Proteins; Inflammation; Intestinal Mucosa; Leukocytes; Maraviroc; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Triazoles; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice.
Topics: Animals; Carrageenan; CD4-Positive T-Lymphocytes; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; Humans; Male; Mice; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
Anti-Inflammatory and Anti-Oxidant Effects of p-Chloro-phenyl-selenoesterol on TNBS-Induced Inflammatory Bowel Disease in Mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Cytokines; Disease Models, Animal; Female; Inflammation Mediators; Inflammatory Bowel Diseases; Mice; Organoselenium Compounds; Oxidative Stress; Peroxidase; Trinitrobenzenesulfonic Acid | 2017 |
Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5(+) B regulatory cells.
Topics: Animals; CD5 Antigens; Cell Proliferation; Colitis; Disease Models, Animal; Humans; Inflammation; Interleukin-10; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Stem Cells; Survival Rate; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2016 |
Topics: Adalimumab; Anemia; Animals; Anti-Inflammatory Agents; Colon; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Infliximab; Intestinal Mucosa; Iron; Male; Malondialdehyde; Patient Outcome Assessment; Psychometrics; Rats; Rats, Wistar; Self Report; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Lung; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Targeting immunoproteasome and glutamine supplementation prevent intestinal hyperpermeability.
Topics: Animals; Avoidance Learning; Colon; Dietary Supplements; Disease Models, Animal; Glutamine; Inflammation; Intestinal Mucosa; Intestines; Male; Mice, Inbred C57BL; Occludin; Permeability; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Trinitrobenzenesulfonic Acid | 2017 |
Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Epoetin Alfa; Inflammation Mediators; Male; Mice; Peroxidase; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2017 |
Fecal Lipocalin-2 as a Sensitive and Noninvasive Biomarker in the TNBS Crohn's Inflammatory Bowel Disease Model.
Topics: Animals; Biomarkers; Colon; Crohn Disease; Disease Models, Animal; Feces; Female; Lipocalin-2; Mice, Inbred BALB C; Research Design; Sensitivity and Specificity; Trinitrobenzenesulfonic Acid | 2016 |
Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fatty Acids, Volatile; Galactans; Gastrointestinal Microbiome; Hydrolysis; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mannans; Mice; Mice, Inbred C57BL; Peroxidase; Plant Gums; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Vitamin D treatment attenuates 2,4,6-trinitrobenzene sulphonic acid (TNBS)-induced colitis but not oxazolone-induced colitis.
Topics: Animals; Apoptosis; Colitis, Ulcerative; Crohn Disease; Cytokines; Disease Models, Animal; Female; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Oxazolone; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid; Vitamin D | 2016 |
Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Animals; Case-Control Studies; Child; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Disease Models, Animal; DNA, Catalytic; Female; GATA3 Transcription Factor; Humans; Intestinal Mucosa; Male; Mice; Mice, Knockout; Middle Aged; Oxazolone; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Young Adult | 2017 |
TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Humans; Immune Tolerance; Jagged-1 Protein; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Poly I-C; Receptor, Notch1; Signal Transduction; T-Lymphocytes, Regulatory; Toll-Like Receptor 3; Transplantation Conditioning; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2017 |
Trinitrobenzene sulfonic acid-induced intestinal injury in neonatal mice activates transcriptional networks similar to those seen in human necrotizing enterocolitis.
Topics: Animals; Animals, Newborn; Disease Models, Animal; Enterocolitis, Necrotizing; Gene Expression Profiling; Gene Regulatory Networks; Humans; Intestinal Mucosa; Intestines; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Species Specificity; Trinitrobenzenesulfonic Acid | 2017 |
The effects of konjac oligosaccharide on TNBS-induced colitis in rats.
Topics: Amorphophallus; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Cyclooxygenase 2; Disease Models, Animal; Humans; Interleukin-1beta; Male; Nitric Oxide Synthase Type II; Oligosaccharides; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
A novel model for studying ileitis-induced visceral hypersensitivity in goats.
Topics: Animals; Cytokines; Disease Models, Animal; Ethanol; Female; Goat Diseases; Goats; Hypersensitivity; Ileitis; Ileum; Inflammatory Bowel Diseases; Male; Peroxidase; Trinitrobenzenesulfonic Acid; Viscera | 2016 |
Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.
Topics: Animals; Biomarkers; Cell Differentiation; Colitis; Disease Models, Animal; Enteroendocrine Cells; Immunohistochemistry; Inflammatory Bowel Diseases; Male; Rats; Stem Cells; Trinitrobenzenesulfonic Acid | 2016 |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Topics: Animals; Colitis; Disease Models, Animal; Forkhead Transcription Factors; Humans; Mice; Receptors, Aryl Hydrocarbon; T-Lymphocytes, Regulatory; Thiazoles; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2016 |
Inflammatory Bowel Disease in a Rodent Model Alters Osteocyte Protein Levels Controlling Bone Turnover.
Topics: Animals; Bone Morphogenetic Proteins; Bone Remodeling; Cancellous Bone; Cytokines; Disease Models, Animal; Genetic Markers; Inflammatory Bowel Diseases; Male; Osteocytes; Osteoprotegerin; Rats; Rats, Sprague-Dawley; Tibia; Trinitrobenzenesulfonic Acid | 2017 |
Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats.
Topics: Animals; Biopsy; Colitis; Colonoscopy; Disease Models, Animal; Endocrine Cells; Intestinal Mucosa; Lymphocytes; Macrophages; Male; Monocytes; Rats; Trinitrobenzenesulfonic Acid | 2016 |
Study on the physicochemical properties and anti-inflammatory effects of paeonol in rats with TNBS-induced ulcerative colitis.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Disease Models, Animal; Humans; Interleukin-17; Interleukin-6; Male; Paeonia; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2017 |
A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation.
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Dopamine Agonists; Dysbiosis; Embryo, Nonmammalian; Gene Expression; High-Throughput Screening Assays; Humans; Immunologic Factors; Intestines; Neutrophils; Receptors, Cholecystokinin; Receptors, Dopamine; Small Molecule Libraries; Trinitrobenzenesulfonic Acid; Zebrafish | 2017 |
Application of carbon nanotubes as the carriers of the cannabinoid, 2-arachidonoylglycerol: Towards a novel treatment strategy in colitis.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Colitis; Disease Models, Animal; Drug Delivery Systems; Endocannabinoids; Glycerides; Inflammation; Male; Microscopy, Electron, Transmission; Nanotubes, Carbon; Oxidative Stress; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Trinitrobenzenesulfonic Acid | 2017 |
The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis.
Topics: 3' Untranslated Regions; Adolescent; Adult; Animals; Antibodies, Blocking; Colitis; Crohn Disease; Disease Models, Animal; Female; Humans; Inflammation; Interleukin-10; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Knockout; MicroRNAs; Middle Aged; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Young Adult | 2017 |
High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.
Topics: Animals; Colitis; Diet; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Male; Mice; Mucosal-Associated Invariant T Cells; Sodium, Dietary; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo.
Topics: ADAM10 Protein; ADAM17 Protein; Animals; Arthritis; Cells, Cultured; Colitis; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Lipopolysaccharides; Macrophages; Mice; Protein Domains; Shock, Septic; Trinitrobenzenesulfonic Acid | 2016 |
Anti-inflammatory effects of an oxylipin-containing lyophilised biomass from a microalga in a murine recurrent colitis model.
Topics: Animal Feed; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomass; Chlamydomonas; Colitis, Ulcerative; Colon; Cytokines; Dietary Supplements; Disease Models, Animal; Disease Progression; Female; Freeze Drying; Gene Expression Regulation; Intestinal Mucosa; Mice, Inbred BALB C; Microalgae; Neutrophil Infiltration; Oxidative Stress; Oxylipins; Secondary Prevention; Trinitrobenzenesulfonic Acid | 2016 |
Monitoring of Chemically Induced Colitis.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Biomarkers; Body Weight; Colitis; Colonoscopy; Cytokines; Disease Models, Animal; Gene Expression; Humans; Immunity, Mucosal; Immunohistochemistry; Mice; Mucous Membrane; Peroxidase; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2017 |
Neonatal mice with necrotizing enterocolitis-like injury develop thrombocytopenia despite increased megakaryopoiesis.
Topics: Animals; Animals, Newborn; Biomarkers; Blood Platelets; Disease Models, Animal; Enterocolitis, Necrotizing; Intestines; Mean Platelet Volume; Megakaryocytes; Mice, Inbred C57BL; Platelet Count; Platelet Membrane Glycoprotein IIb; Ploidies; Thrombocytopenia; Thrombopoiesis; Time Factors; Trinitrobenzenesulfonic Acid | 2017 |
Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Colitis; Cytokines; Dioscorea; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Trinitrobenzenesulfonic Acid | 2017 |
SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging.
Topics: Animals; Blotting, Western; Citrates; Colitis; Colon; Crohn Disease; Cyclooxygenase 2; Disease Models, Animal; Feasibility Studies; Gallium; Male; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon; Trinitrobenzenesulfonic Acid | 2017 |
Recombinant adeno-associated virus carrying thymosin β
Topics: Animals; Cell Proliferation; Colitis, Ulcerative; Colon; Crohn Disease; Dependovirus; Dextran Sulfate; Disease Models, Animal; DNA, Recombinant; Enterocytes; Enzyme-Linked Immunosorbent Assay; Genetic Vectors; Immunochemistry; Interleukin-10; Interleukin-1beta; Intestinal Mucosa; Male; Malondialdehyde; Mice; Mice, Inbred BALB C; Peroxidase; Superoxide Dismutase; Thymosin; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism.
Topics: Actins; Animals; Biomarkers; Cell Count; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Proteolysis; Rats; Regional Blood Flow; Saponins; Stem Cells; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Triterpenes | 2017 |
Therapeutic effect of the immunomodulatory drug lenalidomide, but not pomalidomide, in experimental models of rheumatoid arthritis and inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Collagen Type II; Dextran Sulfate; Disease Models, Animal; Immunologic Factors; Inflammatory Bowel Diseases; Lenalidomide; Male; Mice; Mice, Inbred C57BL; Thalidomide; Trinitrobenzenesulfonic Acid | 2017 |
Immunomodulatory effects of Bifidobacterium bifidum 231 on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Adhesion; Bifidobacterium bifidum; Colitis, Ulcerative; Dexamethasone; Disease Models, Animal; Female; Humans; Immunomodulation; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Investigating the potential of Tamarindus indica pectin-chitosan conjugate for reducing recovery period in TNBS induced colitis.
Topics: Animals; Chitosan; Colitis; Disease Models, Animal; Drug Delivery Systems; Humans; Pectins; Plant Exudates; Rats; Tablets; Tamarindus; Trinitrobenzenesulfonic Acid; Wound Healing | 2017 |
Zebrafish screens for new colitis treatments - a bottom-up approach.
Topics: Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Dysbiosis; High-Throughput Screening Assays; Humans; Immunologic Factors; Intestines; Neutrophils; Trinitrobenzenesulfonic Acid; Zebrafish | 2017 |
Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine Models of Inflammatory Bowel Disease (IBD).
Topics: Acute Disease; Animals; Azoxymethane; Cell Transformation, Neoplastic; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2017 |
Evaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Colitis; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred BALB C; Silver; Trinitrobenzenesulfonic Acid | 2017 |
Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system.
Topics: Animals; Breast Feeding; Colitis; Corticosterone; Disease Models, Animal; Female; Gastrointestinal Hormones; Gene Expression; Lactation; Male; Maternal Exposure; NF-kappa B; Rats; Receptors, Glucocorticoid; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2017 |
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Glutathione; Hydroxybenzoates; Interleukin-1beta; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Peroxidase; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Serine Endopeptidases; Signal Transduction; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Gain | 2017 |
Bovine glycomacropeptide ameliorates experimental rat ileitis by mechanisms involving downregulation of interleukin 17.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cattle; Disease Models, Animal; Down-Regulation; Female; Glycopeptides; Ileitis; Interleukin-17; Macrophages; Mesalamine; Rats; Rats, Wistar; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2008 |
Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: not just trefoil peptides.
Topics: Animals; Apoptosis; Bombesin; Cell Proliferation; Colitis; Disease Models, Animal; Intestinal Mucosa; Neurotensin; Neurotransmitter Agents; Oxidative Stress; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis.
Topics: Animals; Ankyrins; Calcium Channels; Colitis; Colon; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hyperalgesia; Male; Oligodeoxyribonucleotides, Antisense; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Stimulation, Chemical; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Up-Regulation; Visceral Afferents | 2008 |
Effect of different doses of thalidomide in experimentally induced inflammatory bowel disease in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammatory Bowel Diseases; Male; Malondialdehyde; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Thalidomide; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Intrahepatic CD8(+) lymphocyte trapping during tolerance induction using mushroom derived formulations: a possible role for liver in tolerance induction.
Topics: Animals; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Immune Tolerance; Interferon-gamma; Killer Cells, Natural; Liver; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Severity of Illness Index; Shiitake Mushrooms; Trinitrobenzenesulfonic Acid | 2008 |
Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis.
Topics: Analysis of Variance; Animals; Blotting, Western; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glutamine; Inflammation Mediators; Male; Manometry; NF-kappa B; Oxidative Stress; Probability; Random Allocation; Rats; Sensitivity and Specificity; Signal Transduction; Statistics, Nonparametric; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Up-Regulation | 2008 |
Therapeutic potential of two probiotics in inflammatory bowel disease as observed in the trinitrobenzene sulfonic acid model of colitis.
Topics: Animals; Bifidobacterium; Colitis; Disease Models, Animal; Lactobacillus; Male; Peroxidase; Probiotics; Rats; Rats, Wistar; Streptococcus thermophilus; Trinitrobenzenesulfonic Acid | 2008 |
Mycophenolate mofetil promotes down-regulation of expanded B cells and production of TNF-alpha in an experimental murine model of colitis.
Topics: Animals; Antigens, CD19; Antigens, Surface; Apoptosis; B-Lymphocytes; Colitis; Disease Models, Animal; Down-Regulation; Female; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mycophenolic Acid; NF-kappa B; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Glutathione; Honey; Inflammation; Inflammatory Bowel Diseases; Lipid Peroxidation; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2008 |
Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Chemokines; Colitis; Disease Models, Animal; Female; Male; Melatonin; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Colitis; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Intestinal Mucosa; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Vitamin E | 2008 |
Protective effect of salvianolic acid B on chronic pancreatitis induced by trinitrobenzene sulfonic acid solution in rats.
Topics: Animals; Benzofurans; Biomarkers; Body Weight; Disease Models, Animal; Hyaluronic Acid; Laminin; Male; Malondialdehyde; Organ Size; Pancreas; Pancreatitis, Chronic; Protective Agents; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2009 |
Protective effect of ilomastat on trinitrobenzenesulfonic acid-induced ulcerative colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Hydroxamic Acids; Immunohistochemistry; Indoles; Male; Matrix Metalloproteinase 1; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Trinitrobenzenesulfonic Acid | 2008 |
Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis.
Topics: Animals; Cluster Analysis; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Profiling; Genomics; Inflammatory Bowel Diseases; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Early Growth Response Protein 1; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Insulin-Like Growth Factor I; Interleukin-13; Interleukin-13 Receptor alpha2 Subunit; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; RNA; Signal Transduction; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Zinc Fingers | 2008 |
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.
Topics: Animals; Blotting, Western; Chronic Disease; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peroxidase; Trinitrobenzenesulfonic Acid | 2009 |
Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.
Topics: Administration, Oral; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dexamethasone; Disease Models, Animal; Feces; Gastrointestinal Agents; Hydrocortisone; Intestinal Absorption; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfates; Trinitrobenzenesulfonic Acid | 2009 |
[Effect of Kuijieling decoction on proteins expression of IKK-alpha in colonic mucosa of ulcerative colitis model rats].
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; I-kappa B Kinase; Immunohistochemistry; Intestinal Mucosa; Male; Plants, Medicinal; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Attenuation of colitis injury in rats using Garcinia cambogia extract.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dinoprostone; Disease Models, Animal; DNA Damage; Female; Garcinia cambogia; Inflammation Mediators; Male; Peroxidase; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Immunoglobulin E antibodies enhance pulmonary inflammation induced by inhalation of a chemical hapten.
Topics: Airway Resistance; Animals; Asthma; Bronchial Provocation Tests; Bronchoalveolar Lavage Fluid; Cell Count; Chemokine CCL2; Dinitrobenzenes; Disease Models, Animal; Eosinophils; Haptens; Immunization; Immunoglobulin E; Inflammation; Killer Cells, Natural; Lung; Metaplasia; Methacholine Chloride; Mice; Mice, Inbred BALB C; Mice, Knockout; Natural Killer T-Cells; Occupational Diseases; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2009 |
Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI.
Topics: Anesthetics, Inhalation; Animals; Colitis; Colon; Contrast Media; Disease Models, Animal; Disease Progression; Gastrointestinal Agents; Isoflurane; Magnetic Resonance Imaging; Male; Organ Size; Rats; Rats, Wistar; Severity of Illness Index; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2009 |
[The therapeutic effects of heparin on TNBS-induced rat colitis model].
Topics: Animals; Anticoagulants; Colitis; Disease Models, Animal; Heparin; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
Topics: Animals; Base Sequence; Caco-2 Cells; Cloning, Molecular; Colitis; Diarrhea; Disease Models, Animal; Down-Regulation; Humans; Intestinal Mucosa; Jejunum; Lipopolysaccharides; Male; Microvilli; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Sodium-Hydrogen Exchangers; Sp3 Transcription Factor; Time Factors; Transcription Initiation Site; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats.
Topics: Analgesics; Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Electromyography; Gene Expression Regulation; Hyperalgesia; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peroxidase; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Sensory Thresholds; Stress, Psychological; Trinitrobenzenesulfonic Acid | 2009 |
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drug Design; Female; Gastrointestinal Agents; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Salmonella typhimurium; Trinitrobenzenesulfonic Acid | 2009 |
L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation.
Topics: Animals; Carnitine; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Evaluation, Preclinical; Immunosuppressive Agents; Inflammation Mediators; Lipopolysaccharides; Lymphocyte Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Spleen; Trinitrobenzenesulfonic Acid | 2009 |
Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery.
Topics: Animals; Cecum; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Fluorouracil; Glass; Oxazolone; Pectins; Permeability; Polyvinyls; Rats; Steam; Temperature; Trinitrobenzenesulfonic Acid | 2009 |
Optimization of budesonide compression-coated tablets for colonic delivery.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Budesonide; Calorimetry, Differential Scanning; Cellulose; Chemistry, Pharmaceutical; Colitis; Colon; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Galactans; Gastrointestinal Agents; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Male; Mannans; Methylcellulose; Pectins; Plant Gums; Polymethacrylic Acids; Rabbits; Rheology; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2009 |
Ulcerative colitis in AKR mice is attenuated by intraperitoneally administered anandamide.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Colitis, Ulcerative; Cytokines; Disease Models, Animal; Endocannabinoids; Inflammation Mediators; Injections, Intraperitoneal; Mice; Mice, Inbred AKR; Polyunsaturated Alkamides; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
Therapeutic effects of rectal administration of muscovite on experimental colitis in rats.
Topics: Administration, Rectal; Aluminum Silicates; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; HT29 Cells; Humans; Interleukin-1beta; Mesalamine; Mucin-2; Neuropeptides; Rats; Rats, Sprague-Dawley; Trefoil Factor-3; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis.
Topics: Administration, Oral; Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Genistein; Genitalia, Male; Inflammation; Male; Organ Size; Peroxidase; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2009 |
Lactobacillus fermentum CECT 5716 prevents and reverts intestinal damage on TNBS-induced colitis in mice.
Topics: Animals; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Eicosanoids; Immunoenzyme Techniques; Intestinal Mucosa; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Peroxidase; Probiotics; Trinitrobenzenesulfonic Acid; Tyrosine | 2009 |
Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Male; Matrix Metalloproteinases; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Minocycline; Nitric Oxide Synthase Type II; RNA, Messenger; Species Specificity; Survival Analysis; Trinitrobenzenesulfonic Acid | 2009 |
pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model.
Topics: Animals; Budesonide; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Inflammatory Bowel Diseases; Nanospheres; Nanotechnology; Polymers; Rats; Tablets, Enteric-Coated; Trinitrobenzenesulfonic Acid | 2009 |
Effect of Bacillus subtilis PB6, a natural probiotic on colon mucosal inflammation and plasma cytokines levels in inflammatory bowel disease.
Topics: Animals; Bacillus subtilis; Bacterial Proteins; Body Weight; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Intestinal Mucosa; Lipopeptides; Male; Organ Size; Peptides, Cyclic; Phospholipases A2; Probiotics; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Glyburide; Hydrogen Sulfide; Immunohistochemistry; Male; Pinacidil; Probability; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Therapeutic effects of mucosal tolerance on experimental colitis in rats.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Administration, Oral; Animals; Antigens; Colitis; Desensitization, Immunologic; Disease Models, Animal; Immune Tolerance; Immunity, Mucosal; Inflammatory Bowel Diseases; Intestinal Mucosa; Lipopolysaccharides; Male; Ovalbumin; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Toll-Like Receptors; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Therapy, Combination; Male; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Trinitrobenzenesulfonic Acid | 2009 |
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.
Topics: Adoptive Transfer; Animals; Antibodies, Monoclonal; CD27 Ligand; CD4-Positive T-Lymphocytes; Cell Movement; Colitis; Cytokines; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2009 |
Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
Topics: Administration, Oral; Adrenal Glands; Animals; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Glucocorticoids; Male; Methylprednisolone; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfates; Thymus Gland; Trinitrobenzenesulfonic Acid | 2009 |
Slow synaptic transmission in myenteric AH neurons from the inflamed guinea pig ileum.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Electric Stimulation; Excitatory Postsynaptic Potentials; Female; Guinea Pigs; Ileitis; Ileum; Male; Myenteric Plexus; Nerve Fibers; Neurokinin-1 Receptor Antagonists; Protein Kinase C; Protein Kinase Inhibitors; Receptors, Neurokinin-1; Receptors, Neurokinin-3; Synaptic Transmission; Time Factors; Trinitrobenzenesulfonic Acid | 2009 |
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Topics: Animals; Caco-2 Cells; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Colitis; Colon; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression Profiling; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases; Mice; Mice, Knockout; NF-kappa B; Permeability; RNA, Messenger; Signal Transduction; Tight Junctions; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Trinitrobenzenesulfonic Acid; Up-Regulation | 2009 |
Comparison of the population capacity of hematopoietic and mesenchymal stem cells in experimental colitis rat model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Sex-Determining Region Y Protein; Time Factors; Transplantation, Homologous; Trinitrobenzenesulfonic Acid; Y Chromosome | 2009 |
A novel murine model for chronic inflammatory alveolar bone loss.
Topics: Administration, Oral; Alveolar Bone Loss; Alveolar Process; Animals; Chronic Periodontitis; Colon; Cystine; Dextran Sulfate; Disease Models, Animal; Disease Progression; Liver; Mandibular Diseases; Maxillary Diseases; Mice; Mice, Inbred BALB C; Mice, SCID; Periodontium; Time Factors; Trinitrobenzenesulfonic Acid | 2010 |
[Changes of mast cells and gut hormones in rats with TNBS-induced ulcerative colitis].
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Male; Mast Cells; Rats; Rats, Sprague-Dawley; Substance P; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2009 |
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
Topics: Action Potentials; Afferent Pathways; Animals; Bradykinin; Capsaicin; Colitis; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroanatomical Tract-Tracing Techniques; Nodose Ganglion; Pain Measurement; Pelvis; Pressure; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Nerves; Stimulation, Chemical; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel | 2009 |
Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions.
Topics: Acetylcholine; Active Transport, Cell Nucleus; Animals; Binding Sites; Calcium Channels, L-Type; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Enteric Nervous System; Homeostasis; Hormone Antagonists; Humans; I-kappa B Proteins; In Vitro Techniques; Inflammation Mediators; Infusions, Subcutaneous; Muscle Contraction; Muscle, Smooth; Neuroimmunomodulation; NF-kappa B; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Time Factors; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vasoactive Intestinal Peptide | 2009 |
Obesity predisposes to Th17 bias.
Topics: Animals; Colitis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Glycoproteins; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Obesity; Peptide Fragments; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2009 |
Novel immunomodulatory properties of cirsilineol through selective inhibition of IFN-gamma signaling in a murine model of inflammatory bowel disease.
Topics: Animals; Base Sequence; CD4-Positive T-Lymphocytes; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Flavones; Immunologic Factors; Inflammatory Bowel Diseases; Interferon-gamma; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Oligonucleotide Probes; Signal Transduction; Trinitrobenzenesulfonic Acid | 2010 |
Computational flow dynamics in a geometric model of intussusceptive angiogenesis.
Topics: Animals; Biomechanical Phenomena; Blood Circulation; Blood Vessels; Colitis; Computational Biology; Computer Simulation; Disease Models, Animal; Mice; Mice, Inbred BALB C; Models, Biological; Neovascularization, Pathologic; Shear Strength; Stress, Mechanical; Trinitrobenzenesulfonic Acid | 2009 |
Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance.
Topics: Animals; Body Weight; Colitis; Colon; Crohn Disease; Cytokines; Diarrhea; Disease Models, Animal; Drugs, Chinese Herbal; Female; Glycyrrhizic Acid; Humans; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Peroxidase; Trinitrobenzenesulfonic Acid | 2009 |
N-Methyl-D-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Colitis; Colon; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gastrointestinal Motility; Inflammation; Kynurenic Acid; Male; Nitric Oxide Synthase; Peroxidase; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Xanthine Oxidase | 2010 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Lipid Peroxidation; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Superoxide Dismutase; Thalidomide; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
High-dose naproxen aggravates pancreatic fibrosis in a rat model of chronic pancreatitis.
Topics: Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Fibrosis; Male; Naproxen; Pain; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
A33 antigen-deficient mice have defective colonic mucosal repair.
Topics: Animals; Antigens, Neoplasm; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Female; Haptens; Intestinal Mucosa; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid; Wound Healing | 2010 |
The role of dendritic cell subsets in 2,4,6-trinitrobenzene sulfonic acid-induced ileitis.
Topics: Animals; Cell Movement; Clonal Anergy; Cytokines; Dendritic Cells; Disease Models, Animal; Ileitis; Inflammation; Mice; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2010 |
A model for chronic mucosal inflammation in IBD and periodontitis.
Topics: Alveolar Bone Loss; Animals; Chronic Disease; Dextran Sulfate; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Intestines; Mice; Periodontitis; Trinitrobenzenesulfonic Acid; Weight Gain | 2010 |
Bioefficacy of budesonide loaded crosslinked polyelectrolyte microparticles in rat model of induced colitis.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Budesonide; Calcium Chloride; Chitosan; Colitis; Cross-Linking Reagents; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Electrolytes; Glucuronic Acid; Hexuronic Acids; Male; Microspheres; Polymethacrylic Acids; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Effect of COX-2 inhibitor after TNBS-induced colitis in Wistar rats.
Topics: Animals; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Inflammatory Bowel Diseases; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2009 |
Targeting delivery of anti-TNFalpha oligonucleotide into activated colonic macrophages protects against experimental colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Gene Targeting; Genetic Therapy; Genetic Vectors; Inflammation Mediators; Intestinal Mucosa; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotides, Antisense; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Proinflammatory and anti-inflammatory cytokines present in the acute phase of experimental colitis treated with Saccharomyces boulardii.
Topics: Acute Disease; Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Male; Probiotics; Rats; Rats, Wistar; Saccharomyces; Severity of Illness Index; Time Factors; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Expression of sonic hedgehog signaling pathways in a rat model of chronic pancreatitis.
Topics: Amylases; Animals; Bilirubin; Collagen; Disease Models, Animal; Hedgehog Proteins; Pancreas; Pancreatitis, Chronic; Rats; Rats, Wistar; Signal Transduction; Transcriptional Activation; Trinitrobenzenesulfonic Acid | 2010 |
Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antibodies; Carbon Monoxide; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Peroxidase; RNA, Messenger; Spleen; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
A new model of chronic hapten-induced colitis in young rats.
Topics: Animals; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Fibrosis; Haptens; Inflammation Mediators; Organ Size; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Ulcer | 2010 |
Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Gastrointestinal Motility; Helminth Proteins; Male; Mice; Peristalsis; Schistosoma mansoni; T-Lymphocyte Subsets; Trinitrobenzenesulfonic Acid | 2010 |
Preventive effects of Schistosoma japonicum ova on trinitrobenzenesulfonic acid-induced colitis and bacterial translocation in mice.
Topics: Animals; Bacterial Translocation; Colitis; Colon; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Injections, Intraperitoneal; Interferon-gamma; Interleukin-10; Mice; Mice, Inbred BALB C; Ovum; Polymerase Chain Reaction; RNA, Messenger; Schistosoma japonicum; T-Lymphocytes, Helper-Inducer; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Female; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; MicroRNAs; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Agents; Inflammation Mediators; Interleukin-1beta; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Plant Components, Aerial; Plant Preparations; Rats; Rats, Wistar; Teucrium; Thiobarbituric Acid Reactive Substances; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease.
Topics: Adamantane; Aminosalicylic Acids; Animals; Body Weight; Colon; Crohn Disease; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Epithelial Cells; Female; Gastrointestinal Agents; Humans; Interleukin-1beta; Leukocytes; Male; Mice; Mice, Inbred C57BL; Neutrophils; Peroxidase; Phosphotransferases (Alcohol Group Acceptor); Prednisolone; Pyridines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Chemokine CCL2; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Inflammatory Bowel Diseases; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Trinitrobenzenesulfonic Acid | 2010 |
Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Genetic Predisposition to Disease; Inflammation Mediators; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Knockout; Pilot Projects; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2010 |
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease.
Topics: Acute Disease; Animals; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Chronic Disease; Colitis; Dextran Sulfate; Dicarboxylic Acids; Dihydroorotate Dehydrogenase; Disease Models, Animal; Female; Immunoenzyme Techniques; Immunosuppressive Agents; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Oxidoreductases Acting on CH-CH Group Donors; Trinitrobenzenesulfonic Acid | 2010 |
Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis; Disease Models, Animal; Glutathione; Male; Peroxidase; Rats; Rats, Wistar; Scopoletin; Structure-Activity Relationship; Sulfasalazine; Trinitrobenzenesulfonic Acid; Umbelliferones | 2010 |
Rotavirus-like particles: a novel nanocarrier for the gut.
Topics: Analysis of Variance; Animals; Baculoviridae; Cell Line; Colitis; Disease Models, Animal; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Green Fluorescent Proteins; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Rotavirus; Spodoptera; Trinitrobenzenesulfonic Acid; Virion; Virus Internalization | 2010 |
Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.
Topics: Animals; Anti-Inflammatory Agents; Candy; Colitis; Colon; Disaccharides; Disease Models, Animal; Female; Food Handling; Food, Fortified; Glycosylation; Hot Temperature; Oligosaccharides; Prebiotics; Rats; Rats, Wistar; Stereoisomerism; Sucrose; Trinitrobenzenesulfonic Acid | 2010 |
Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis.
Topics: Animals; Base Sequence; Brain; Colitis; Colon; Disease Models, Animal; DNA Primers; Female; Gene Expression; Humans; Inflammatory Bowel Diseases; Interleukin-6; Neuroimmunomodulation; Peroxidase; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2010 |
Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Exosomes; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-2; Male; Mucous Membrane; Rats; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Anti-inflammatory effect of enzymatic hydrolysate of corn gluten in an experimental model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon, Descending; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Food, Formulated; Glutens; Histamine; Intestinal Mucosa; Male; Peroxidase; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Seeds; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Zea mays | 2010 |
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.
Topics: Animals; Cannabidiol; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Therapy, Combination; Gastrointestinal Motility; In Vitro Techniques; Inflammation; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2010 |
Ecabet sodium promotes the healing of trinitrobenzene-sulfonic-acid-induced ulceration by enhanced restitution of intestinal epithelial cells.
Topics: Abietanes; Acute Disease; Administration, Rectal; Animals; Anti-Ulcer Agents; Cell Line; Cell Movement; Colitis, Ulcerative; Colon; Disease Models, Animal; Enema; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Intestinal Mucosa; Male; Phosphorylation; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Wound Healing | 2010 |
Colonic delivery of carboxyfluorescein by pH-sensitive microspheres in experimental colitis.
Topics: Administration, Oral; Administration, Rectal; Animals; Biological Availability; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Fluoresceins; Hydrogen-Ion Concentration; Male; Microspheres; Polymethacrylic Acids; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2010 |
Protective effects of black cumin (Nigella sativa) oil on TNBS-induced experimental colitis in rats.
Topics: Animals; Cholesterol; Colitis, Ulcerative; Colon; Cytokines; Disease Models, Animal; Female; L-Lactate Dehydrogenase; Male; Malondialdehyde; Nigella sativa; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Treatment Outcome; Triglycerides; Trinitrobenzenesulfonic Acid | 2011 |
Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules.
Topics: Administration, Oral; Administration, Rectal; Animals; Capsules; Colitis; Colon; Dipeptides; Disease Models, Animal; Drug Delivery Systems; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Male; Phthalimides; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2010 |
Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-κB down-regulation and caspase-3 activation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Oxides; Peroxidase; Trinitrobenzenesulfonic Acid | 2011 |
Protective effects of N(G)-nitro-L-arginine methyl ester and metallothioneins on excess nitric oxide toxicity in trinitrobenzene sulfonic acid-induced rat colitis.
Topics: Animals; Blood Cell Count; Bone Marrow; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Intestinal Mucosa; Male; Metallothionein; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Trinitrobenzenesulfonic Acid | 2010 |
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Hyperplasia; Hypertrophy; Inflammation; Inflammation Mediators; Muscle, Smooth; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.
Topics: Adoptive Transfer; Animals; Bone Marrow Transplantation; CD11b Antigen; Cell Communication; Cell Tracking; Coculture Techniques; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunophenotyping; Interleukin-2 Receptor alpha Subunit; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Phenotype; Spleen; Stromal Cells; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats.
Topics: Animal Feed; Animals; Body Weight; Chemokines; Colitis; Colon; Disease Models, Animal; Endotoxemia; Endotoxins; Enema; Enteral Nutrition; Fatty Acids, Omega-3; Male; Peroxidase; Rats; Rats, Wistar; Triglycerides; Trinitrobenzenesulfonic Acid | 2010 |
The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis.
Topics: Animals; Antioxidants; Cholagogues and Choleretics; Colitis; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Male; NF-kappa B; Rats; Rats, Wistar; Silybin; Silymarin; Trinitrobenzenesulfonic Acid; Ursodeoxycholic Acid | 2011 |
Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model.
Topics: Adrenomedullin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Line; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Flow Cytometry; Gene Expression; Immunohistochemistry; Interferon-gamma; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Panax; Phytotherapy; Plant Extracts; Rats; Serum Amyloid A Protein; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation; Zanthoxylum; Zingiberaceae | 2010 |
A novel TRPV1 receptor antagonist JNJ-17203212 attenuates colonic hypersensitivity in rats.
Topics: Acetic Acid; Administration, Oral; Aminopyridines; Animals; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Irritable Bowel Syndrome; Male; Piperazines; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2010 |
Use of superoxide dismutase and catalase producing lactic acid bacteria in TNBS induced Crohn's disease in mice.
Topics: Animals; Body Weight; Catalase; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; Genetic Engineering; Histocytochemistry; Inflammation; Intestine, Large; Lacticaseibacillus casei; Liver; Mice; Mice, Inbred BALB C; Probiotics; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2011 |
A chemical enterocolitis model in zebrafish larvae that is dependent on microbiota and responsive to pharmacological agents.
Topics: Animals; Anti-Inflammatory Agents; Disease Models, Animal; Embryo, Nonmammalian; Enterocolitis; Gastrointestinal Tract; Haptens; Humans; Larva; Leukocytes; Metagenome; Myeloid Differentiation Factor 88; Trinitrobenzenesulfonic Acid; Zebrafish | 2011 |
Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Electromyography; Evoked Potentials; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hyperalgesia; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons, Afferent; Pressure; Rectum; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis.
Topics: Administration, Rectal; Animals; Anti-Ulcer Agents; Calcineurin; Calcineurin Inhibitors; Carnosine; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Gene Expression; Humans; Interleukin-2; Intestinal Mucosa; Jurkat Cells; Male; NFATC Transcription Factors; Organometallic Compounds; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Zinc Compounds | 2011 |
Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats.
Topics: Actins; Animals; Biomarkers; Blotting, Western; Cyclooxygenase 2; Disease Models, Animal; Disease Progression; Drugs, Chinese Herbal; Interleukin-10; Interleukin-1beta; Pancreas; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.
Topics: Animals; Caco-2 Cells; Chenodeoxycholic Acid; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Drug Evaluation, Preclinical; Gene Expression Regulation; Humans; Ileum; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Absorption; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis.
Topics: Animals; Bifidobacterium; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-1beta; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Probiotics; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2011 |
α-Tocopherol treatment ameliorates chronic pancreatitis in an experimental rat model induced by trinitrobenzene sulfonic acid.
Topics: Administration, Oral; alpha-Tocopherol; Animals; Antioxidants; Body Weight; Disease Models, Animal; Disease-Free Survival; Fibrosis; Kaplan-Meier Estimate; Longevity; Male; Organ Size; Pancreas; Pancreatic Pseudocyst; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Proteinase-activated receptor 2 mediates thermal hyperalgesia and is upregulated in a rat model of chronic pancreatitis.
Topics: Abdominal Pain; Analgesics; Animals; Behavior, Animal; Blotting, Western; Disease Models, Animal; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Ganglia, Spinal; Glycoproteins; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation | 2011 |
Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model.
Topics: Animals; Antibodies, Monoclonal; Crohn Disease; Diarrhea; Disease Models, Animal; Female; Fingolimod Hydrochloride; Gastrointestinal Agents; Interleukin-12; Interleukin-23; Mice; Mice, Inbred BALB C; Organ Size; Propylene Glycols; Sphingosine; Sulfasalazine; Trinitrobenzenesulfonic Acid; Weight Loss | 2011 |
Chronic lithium administration ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats; potential role for adenosine triphosphate sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Follow-Up Studies; Intestinal Mucosa; Lithium; Male; Potassium Channels; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Klebsiella pneumoniae increases the risk of inflammation and colitis in a murine model of intestinal bowel disease.
Topics: Animals; Biomarkers; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Klebsiella Infections; Klebsiella pneumoniae; Lactobacillus; Lipid Peroxidation; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Trinitrobenzenesulfonic Acid | 2011 |
Chemokine CXCL11 links microbial stimuli to intestinal inflammation.
Topics: Adult; Aged; Animals; Cell Differentiation; Cells, Cultured; Chemokine CXCL11; Colitis, Ulcerative; Disease Models, Animal; Female; Flagellin; Humans; Immunization; Inflammation; Interleukin-17; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Middle Aged; Th1-Th2 Balance; Th17 Cells; Trinitrobenzenesulfonic Acid | 2011 |
Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis.
Topics: Analgesics; Analysis of Variance; Animals; Antibodies; Disease Models, Animal; Down-Regulation; Hyperalgesia; Male; Membrane Potentials; Nerve Growth Factor; Pain; Pain Threshold; Pancreas; Pancreatitis, Chronic; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sensory Receptor Cells; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2011 |
The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.
Topics: Animals; Antigens, Helminth; Colitis; Colon; Cytokines; Disease Models, Animal; Helminth Proteins; Immunoglobulin G; Immunomodulation; Injections, Subcutaneous; Male; Mice; Mice, Inbred BALB C; Recombinant Proteins; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2011 |
Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis.
Topics: Animals; Blotting, Western; Chondroitin Sulfate Proteoglycans; Colitis; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Flow Cytometry; Haptens; Inflammation; Keratan Sulfate; Lipopolysaccharides; Lumican; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Colitis; Disease Models, Animal; Endocannabinoids; Endotoxemia; Enzyme Inhibitors; Glycerides; Humans; Indoles; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Trinitrobenzenesulfonic Acid | 2011 |
The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis.
Topics: Animals; Colitis; Collagen Type I; Colon; Disease Models, Animal; Female; Fibrosis; Inflammation; Interleukin-18; Intestinal Mucosa; Intestines; Organ Size; Pentoxifylline; Peroxidase; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Azithromycin; CD11b Antigen; Colitis; Collagen; Dextran Sulfate; Disease Models, Animal; Drug Discovery; Female; Humans; Immunologic Factors; Inflammation; Inflammatory Bowel Diseases; Male; Mice; Mucous Membrane; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2011 |
Immunomodulatory and therapeutic potential of a mycelial lectin from Aspergillus nidulans.
Topics: Anaphylaxis; Animals; Arthus Reaction; Aspergillus nidulans; Cattle; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Immunologic; Fungal Proteins; Immunologic Factors; Interferon-gamma; Interleukin-6; Lectins; Macrophages; Male; Mice; Mycelium; Nitric Oxide; Rats; Rats, Wistar; Serum Albumin; Trinitrobenzenesulfonic Acid | 2011 |
Aryl hydrocarbon receptor-induced signals up-regulate IL-22 production and inhibit inflammation in the gastrointestinal tract.
Topics: Adult; Animals; Basic Helix-Loop-Helix Transcription Factors; Biopsy; Carbazoles; Case-Control Studies; Cells, Cultured; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Flow Cytometry; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-22; Interleukins; Intestines; Mice; Mice, Inbred BALB C; Middle Aged; Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Severity of Illness Index; Signal Transduction; T-Lymphocytes; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2011 |
Proanthocyanidins from grape seeds modulates the nuclear factor-kappa B signal transduction pathways in rats with TNBS-induced recurrent ulcerative colitis.
Topics: Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Humans; Immunomodulation; Inflammation; Male; NF-kappa B; Oxidative Stress; Proanthocyanidins; Rats; Rats, Wistar; Recurrence; Seeds; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vitis | 2011 |
N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with TNBS-induced colitis model in rats.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Freeze Drying; Intestinal Mucosa; Lymphocyte Activation; Male; Mesalamine; Organ Size; Peroxidase; Polymers; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
Topics: Analysis of Variance; Animals; Cannabidiol; Cannabinoids; Chemotaxis, Leukocyte; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neutrophil Infiltration; Neutrophils; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Resorcinols; Trinitrobenzenesulfonic Acid | 2011 |
Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle.
Topics: Acetylcholine; Animals; Calcium Channels, L-Type; Colitis; Colon; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hydrogen Peroxide; Inflammatory Bowel Diseases; Intestinal Mucosa; Isothiocyanates; Male; Muscle, Smooth; NF-E2-Related Factor 2; Oxidative Stress; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Sulfoxides; Thiocyanates; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Glycyrrhizic Acid; Interleukin-10; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Spleen; Trinitrobenzenesulfonic Acid | 2011 |
Neuroimmunomodulative properties of dipeptidyl peptidase IV/CD26 in a TNBS-induced model of colitis in mice.
Topics: Animals; Blotting, Western; Colitis; Dipeptidyl Peptidase 4; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukins; Mice; Mice, Knockout; Neuropeptide Y; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2011 |
The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.
Topics: Actins; Animals; Anti-Bacterial Agents; Bone Marrow Transplantation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Nod2 Signaling Adaptor Protein; Peptide Transporter 1; Promoter Regions, Genetic; Severity of Illness Index; Signal Transduction; Symporters; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
TRPA1 and substance P mediate colitis in mice.
Topics: Aldehydes; Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes; Ganglia, Spinal; HEK293 Cells; Humans; Inflammation Mediators; Lipid Peroxidation; Membrane Potentials; Mice; Mice, Knockout; Mutation; Nerve Tissue Proteins; Patch-Clamp Techniques; Substance P; Transfection; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPV Cation Channels | 2011 |
Repeated enemas with hepatocyte growth factor selectively stimulate epithelial cell proliferation of injured mucosa in rats with experimental colitis.
Topics: Administration, Rectal; Animals; Cell Proliferation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Rats; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 2011 |
Biochemical and pathological evidences on the benefit of a new biodegradable nanoparticles of probiotic extract in murine colitis.
Topics: Animals; Chitosan; Colitis; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Freeze Drying; Inflammation Mediators; Lactic Acid; Lipid Peroxidation; Male; Nanoparticles; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
Topics: Animals; Colitis; Cyclic GMP; Disease Models, Animal; Glyburide; KATP Channels; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Trinitrobenzenesulfonic Acid | 2012 |
Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease.
Topics: Animals; Biomechanical Phenomena; Colitis; Colon; Crohn Disease; Diagnosis, Differential; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Elasticity; Female; Fibrosis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestine, Small; Pilot Projects; Rats; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid; Ultrasonography | 2011 |
The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Azo Compounds; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Platelet Activating Factor; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model.
Topics: Adrenomedullin; Amides; Animals; Calcitonin Gene-Related Peptide; Cell Line; Colitis; Colon; Crohn Disease; Disease Models, Animal; Intestinal Mucosa; Male; Microvessels; Panax; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; Up-Regulation; Vasodilation; Zanthoxylum; Zingiberaceae | 2011 |
The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats.
Topics: Animals; Colitis; Colonoscopy; Disease Models, Animal; Female; Follow-Up Studies; Intestinal Mucosa; Rats; Rats, Wistar; Reproducibility of Results; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2011 |
The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cholesterol; Colitis; Colon; Disease Models, Animal; Female; Glutathione; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; Male; Malondialdehyde; N-Acetylneuraminic Acid; Oxidative Stress; Peroxidase; Plant Oils; Rats; Rats, Wistar; Seeds; Superoxide Dismutase; Triglycerides; Trinitrobenzenesulfonic Acid; Urtica dioica | 2011 |
On the benefit of whey-cultured Lactobacillus casei in murine colitis.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dexamethasone; Disease Models, Animal; Ethanol; Lacticaseibacillus casei; Lipid Peroxidation; Male; Mice; Milk Proteins; Peroxidase; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Whey Proteins | 2011 |
Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis.
Topics: Animals; Body Weight; Cell Differentiation; Cell Movement; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Immunity, Cellular; Immunosuppression Therapy; Injections, Intraperitoneal; Interferon-gamma; Intestinal Mucosa; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Serum Amyloid A Protein; Trinitrobenzenesulfonic Acid | 2011 |
Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Flow Cytometry; Ileitis; Inflammation; Mice; Mice, Inbred BALB C; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2011 |
Effect of combination of thalidomide and sulfasalazine in experimentally induced inflammatory bowel disease in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Disease Models, Animal; Drug Therapy, Combination; Female; Immunosuppressive Agents; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Rats; Rats, Wistar; Sulfasalazine; Thalidomide; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blotting, Western; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes, Clerodane; Gastrointestinal Motility; Male; Mice; Naltrexone; Pain; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Salvia; Trinitrobenzenesulfonic Acid | 2012 |
Spinal microglia initiate and maintain hyperalgesia in a rat model of chronic pancreatitis.
Topics: Animals; Blotting, Western; CD11 Antigens; Chemokine CX3CL1; Disease Models, Animal; Enzyme Activation; Hyperalgesia; Immunohistochemistry; Male; Microglia; Minocycline; p38 Mitogen-Activated Protein Kinases; Pain Measurement; Pain Threshold; Pancreatitis, Chronic; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord; Thoracic Vertebrae; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Cells, Cultured; Colitis; Colon; Culture Media; Disease Models, Animal; Drugs, Chinese Herbal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mycelium; Reishi; Trinitrobenzenesulfonic Acid | 2011 |
Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model.
Topics: Animals; Colitis; Collagen Type I; Colon; Disease Models, Animal; Fibrosis; Gastrointestinal Agents; HSP47 Heat-Shock Proteins; Intestinal Mucosa; Male; Medicine, Kampo; Panax; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Ulcer; Zanthoxylum; Zingiberaceae | 2011 |
Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents; Buffers; Caffeic Acids; Chemistry, Pharmaceutical; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Compounding; Drug Implants; Drug Stability; Gastrointestinal Agents; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypromellose Derivatives; Male; Methylcellulose; Rats; Rats, Wistar; Rutin; Solubility; Technology, Pharmaceutical; Time Factors; Trinitrobenzenesulfonic Acid; Zinc Acetate | 2012 |
[Crohn disease in rats induced by different concentrations of trinitrobenzenesulfonic acid and ethanol].
Topics: Animals; Crohn Disease; Disease Models, Animal; Ethanol; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation.
Topics: Adoptive Transfer; Animals; Antibodies; Colitis; Colon; Disease Models, Animal; Immunity, Mucosal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Receptors, Antigen, T-Cell, alpha-beta; RNA, Messenger; Severity of Illness Index; Spleen; T-Lymphocyte Subsets; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
The effect of progesterone in the prevention of the chemically induced experimental colitis in rats.
Topics: Animals; Apoptosis; Colitis; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Intestinal Mucosa; Male; Malondialdehyde; Nitric Oxide; Progesterone; Progestins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics.
Topics: Animals; Biomarkers; Chemokines; Colitis; Cytokines; Disease Models, Animal; Female; Gene Expression Profiling; Immunoenzyme Techniques; Inflammation; Mast Cells; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Probiotics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Secondary Prevention; Trinitrobenzenesulfonic Acid | 2012 |
Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model.
Topics: Animals; Cell Line; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Osteopontin ablation attenuates progression of colitis in TNBS model.
Topics: Animals; Biopsy, Needle; Colitis; Disease Models, Animal; Disease Progression; Flow Cytometry; Immunohistochemistry; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteopontin; Random Allocation; Reference Values; Sensitivity and Specificity; Serum Amyloid A Protein; Trinitrobenzenesulfonic Acid | 2012 |
Magnetic resonance colonography in rats with TNBS-induced colitis: a feasibility and validation study.
Topics: Animals; Blotting, Western; Colitis; Colonoscopy; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Feasibility Studies; Inflammation Mediators; Intestinal Mucosa; Magnetic Resonance Imaging; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2012 |
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Colitis; Disease Models, Animal; Disease Progression; Down-Regulation; Fibrosis; Intestinal Mucosa; Losartan; Male; Rats; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2012 |
Chemically induced mouse models of colitis.
Topics: Animal Husbandry; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2009 |
Methods of inducing inflammatory bowel disease in mice.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Helicobacter Infections; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Specimen Handling; Trinitrobenzenesulfonic Acid | 2009 |
Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat.
Topics: Analysis of Variance; Animals; Antibodies, Neutralizing; Brain-Derived Neurotrophic Factor; Colitis; Colon; Disease Models, Animal; Diterpenes; Drug Administration Schedule; Drug Delivery Systems; Ganglia, Spinal; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Ubiquitin Thiolesterase; Up-Regulation; Urinary Bladder; Urination | 2012 |
BMP signaling in rats with TNBS-induced colitis following BMP7 therapy.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Carrier Proteins; Colitis; Connective Tissue Growth Factor; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Trinitrobenzenesulfonic Acid | 2012 |
β-Casein hydrolysate generated by the cell envelope-associated proteinase of Lactobacillus delbrueckii ssp. lactis CRL 581 protects against trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Antimutagenic Agents; Caseins; Colitis; Disease Models, Animal; Female; Glucuronidase; Lactobacillus delbrueckii; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Peroxidase; Protein Hydrolysates; Trinitrobenzenesulfonic Acid | 2012 |
Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice.
Topics: Administration, Oral; Administration, Rectal; Administration, Topical; Animals; Anti-Inflammatory Agents; Cannabidiol; Colitis; Disease Models, Animal; Injections, Intraperitoneal; Male; Mice; Peroxidase; Trinitrobenzenesulfonic Acid | 2012 |
Adenovirus-mediated hepatocarcinoma-intestine-pancreas/pancreatitis-associated protein suppresses dextran sulfate sodium-induced acute ulcerative colitis in rats.
Topics: Acute Disease; Adenocarcinoma; Adenoviridae; Animals; Antigens, Neoplasm; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Proliferation; Colitis, Ulcerative; Colon; Colonic Neoplasms; Disease Models, Animal; Gene Expression Profiling; Hydrogen Peroxide; Immunoenzyme Techniques; Inflammation; Interleukin-6; Intestinal Mucosa; Lectins, C-Type; Malondialdehyde; Oligonucleotide Array Sequence Analysis; Oxidants; Oxidative Stress; Pancreatitis-Associated Proteins; Peroxidase; Rats; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2012 |
Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Male; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis.
Topics: Animals; Apoptosis; Bone Marrow Cells; Cell Lineage; Cell Movement; Colitis; Collagen; Colon; Colonoscopy; Cryopreservation; Cytokines; Disease Models, Animal; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Mucosa; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Subcutaneous Fat; Trinitrobenzenesulfonic Acid; Wound Healing | 2012 |
Nanoparticle-based clodronate delivery mitigates murine experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Line; Cell Survival; Clodronic Acid; Colitis; Disease Models, Animal; Humans; Mice; Nanoparticles; Oxazolone; Polymers; Trinitrobenzenesulfonic Acid | 2012 |
Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dietary Supplements; Disease Models, Animal; Drug Synergism; Flour; Fruit; Glutathione; Inflammation; Lipid Peroxidation; Male; Musa; Oxidation-Reduction; Peroxidase; Phytotherapy; Plant Preparations; Prebiotics; Prednisolone; Rats, Wistar; Starch; Trinitrobenzenesulfonic Acid | 2012 |
Protective effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis induced by trinitrobenzenesulfonic acid in rats.
Topics: Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Glutathione; Glutathione Peroxidase; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Shikimic Acid; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2012 |
Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics--a pilot study.
Topics: Acute Disease; Animals; Biomarkers; Chromatography, Liquid; Colitis; Disease Models, Animal; Male; Metabolomics; Pilot Projects; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid | 2012 |
Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Diarrhea; Dietary Fiber; Dietary Supplements; Disease Models, Animal; Flour; Glutathione; Inflammation; Intestinal Mucosa; Male; Organ Size; Peroxidase; Phytotherapy; Plant Preparations; Prednisolone; Rats; Rats, Wistar; Rhizome; Trinitrobenzenesulfonic Acid; Typhaceae | 2012 |
Retinoic acid suppresses intestinal mucus production and exacerbates experimental enterocolitis.
Topics: Animals; Dextran Sulfate; Disease Models, Animal; Enterocolitis; Inflammation; Intestinal Mucosa; Intestines; Larva; Metagenome; Mice; Mucins; Mucus; Neutrophils; Phenotype; Tretinoin; Trinitrobenzenesulfonic Acid; Zebrafish | 2012 |
Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats.
Topics: Alkaline Phosphatase; Animals; Bacterial Translocation; Colitis; Dextran Sulfate; Disease Models, Animal; DNA, Bacterial; Feces; Female; Gene Expression Regulation, Enzymologic; Liver; Mice; Mice, Inbred C57BL; Mice, SCID; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis.
Topics: Adipose Tissue; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Survival; Colitis; Disease Models, Animal; Gene Expression; Humans; Infliximab; Interleukin-10; JNK Mitogen-Activated Protein Kinases; Male; Mesentery; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; PPAR gamma; Rats; Rats, Wistar; Resistin; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; U937 Cells | 2012 |
Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats.
Topics: Animals; Colitis; Disease Models, Animal; Ethanol; Irritable Bowel Syndrome; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2012 |
Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Crohn Disease; Cyclooxygenase 2; Dietary Supplements; Disease Models, Animal; Ellagic Acid; I-kappa B Proteins; Interferon-alpha; Intestinal Mucosa; Lythraceae; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Plant Extracts; Polyphenols; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2012 |
Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice.
Topics: Animals; Anti-Inflammatory Agents; Bacillus subtilis; Body Weight; Cell Line; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-12; Leukocytes, Mononuclear; Mice; Neutrophils; Probiotics; Serum Amyloid A Protein; Spores, Bacterial; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Reappraisal of total body irradiation followed by bone marrow transplantation as a therapy for inflammatory bowel disease.
Topics: Animals; Bone Marrow Transplantation; Colitis; Combined Modality Therapy; Cytokines; Disease Models, Animal; Female; Humans; Immunosuppression Therapy; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Weight Gain; Whole-Body Irradiation | 2013 |
MC-12, an annexin A1-based peptide, is effective in the treatment of experimental colitis.
Topics: Animals; Annexin A1; Cell Line; Colitis; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Female; Group IV Phospholipases A2; Humans; Intestinal Mucosa; Mice; NF-kappa B; Oligopeptides; Peroxidase; Trinitrobenzenesulfonic Acid | 2012 |
Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice.
Topics: Administration, Rectal; Animals; Colitis; Colon; Disease Models, Animal; Hypersensitivity; Immunoenzyme Techniques; Immunohistochemistry; Inflammation; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Physical Stimulation; Rectum; Saline Solution, Hypertonic; Time Factors; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2012 |
Therapeutic effect of ginsenoside Rd in rats with TNBS-induced recurrent ulcerative colitis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis, Ulcerative; Colon; Disease Models, Animal; Gastrointestinal Agents; Ginsenosides; Glutathione Peroxidase; Male; Malondialdehyde; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Recurrence; Superoxide Dismutase; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
Mucosal healing and fibrosis after acute or chronic inflammation in wild type FVB-N mice and C57BL6 procollagen α1(I)-promoter-GFP reporter mice.
Topics: Acute Disease; Animals; Antigens; Chronic Disease; Collagen Type I; Collagen Type I, alpha 1 Chain; Colon; Dextran Sulfate; Disease Models, Animal; Female; Fibrosis; Genes, Reporter; Green Fluorescent Proteins; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myofibroblasts; Promoter Regions, Genetic; Survival Analysis; Trinitrobenzenesulfonic Acid; Vimentin; Weight Loss; Wound Healing | 2012 |
Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis.
Topics: Amidines; Animals; Brain-Derived Neurotrophic Factor; Colitis; Colon; Disease Models, Animal; Diterpenes; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Male; Mitogen-Activated Protein Kinase 7; Nerve Growth Factor; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2012 |
[Comparative study of novel therapeutic possibilities in animal experimental model of inflammatory bowel disease].
Topics: Administration, Oral; Animals; Biomarkers; Colitis; Disease Models, Animal; Excitatory Amino Acid Antagonists; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Kynurenic Acid; Microcirculation; Microscopy, Confocal; Peroxidase; Phosphatidylcholines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Blotting, Western; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Drug Synergism; Female; Gene Expression; Interferon-gamma; Interleukin-1beta; Interleukin-2; Nitric Oxide Synthase Type II; Organ Size; Polysaccharides; Prebiotics; Probiotics; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Gain | 2013 |
Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.
Topics: Acetic Acid; Action Potentials; Animals; Anthracenes; Colitis; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Guinea Pigs; Indicators and Reagents; Intestines; Myenteric Plexus; Reaction Time; Riluzole; Trinitrobenzenesulfonic Acid | 2012 |
Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.
Topics: Animals; Cell Count; Colitis; Colon; Dependovirus; Disease Models, Animal; DNA, Complementary; Epitopes, T-Lymphocyte; Forkhead Transcription Factors; Genetic Therapy; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Thymus Gland; Trinitrobenzenesulfonic Acid | 2012 |
Cytokine expression and the role of Th17 cells in a mouse model of colitis.
Topics: Animals; Antibodies; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Interferon-gamma; Interleukin-17; Interleukin-6; Leukocytes, Mononuclear; Lymph Nodes; Mice; Mice, Inbred BALB C; RNA, Messenger; Spleen; Th17 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.
Topics: Animals; Anti-Bacterial Agents; Carrier Proteins; Colitis; Dendritic Cells; Disease Models, Animal; Environment; Epithelial Cells; Genetic Predisposition to Disease; Humans; Immune Tolerance; Inflammasomes; Inflammatory Bowel Diseases; Intestines; Metagenome; Mice; Mucous Membrane; NLR Family, Pyrin Domain-Containing 3 Protein; Phenotype; Protective Agents; Trinitrobenzenesulfonic Acid | 2012 |
Cytokine expression and the role of Thl7 cells in mice colitis.
Topics: Animals; Antibodies; Blotting, Western; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Inflammation Mediators; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spleen; Th1 Cells; Th17 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats.
Topics: Abdominal Pain; Animals; Colitis; Colon; Disease Models, Animal; Dyspepsia; Glucocorticoids; Hypersensitivity; Male; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stomach Diseases; Trinitrobenzenesulfonic Acid | 2013 |
A low dose of fermented soy germ alleviates gut barrier injury, hyperalgesia and faecal protease activity in a rat model of inflammatory bowel disease.
Topics: Animals; Cytokines; Disease Models, Animal; Enzyme Activation; Feces; Female; Glycine max; Humans; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Peptide Hydrolases; Permeability; Plant Extracts; Rats; Receptor, PAR-2; Trinitrobenzenesulfonic Acid; Weight Loss | 2012 |
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Ketotifen; Mast Cells; Membrane Transport Modulators; Mice; Mice, Knockout; Muscle Contraction; Neurons, Afferent; Oligopeptides; p-Methoxy-N-methylphenethylamine; Permeability; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urination Disorders | 2013 |
Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Heme Oxygenase-1; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; Real-Time Polymerase Chain Reaction; Sepharose; Time Factors; Trinitrobenzenesulfonic Acid | 2013 |
Effectiveness of Saccharomyces boulardii in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammation Mediators; Methylprednisolone; Nitric Oxide; Probiotics; Rats; Rats, Wistar; Saccharomyces; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents; Budesonide; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Immunomodulation; Inflammation; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Signal Transduction; Th1-Th2 Balance; Time Factors; Transcriptome; Trinitrobenzenesulfonic Acid | 2012 |
Sesame oil accelerates healing of 2,4,6-trinitrobenzenesulfonic acid-induced acute colitis by attenuating inflammation and fibrosis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Fibrosis; Inflammation; Male; Organ Size; Rats; Rats, Wistar; Sesame Oil; Trinitrobenzenesulfonic Acid | 2013 |
Dose-dependent antiinflammatory effect of ursodeoxycholic acid in experimental colitis.
Topics: Administration, Oral; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis, Ulcerative; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Intestinal Mucosa; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Ursodeoxycholic Acid | 2013 |
Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Curcumin; Disease Models, Animal; Gastrointestinal Agents; Inflammation; Interleukins; Intestinal Mucosa; Male; NF-kappa B; Peroxidase; Random Allocation; Rats; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2013 |
Involvement of the NO-cGMP-K(ATP) channel pathway in the mesenteric lymphatic pump dysfunction observed in the guinea pig model of TNBS-induced ileitis.
Topics: Animals; ATP-Binding Cassette Transporters; Disease Models, Animal; Enzyme Inhibitors; Glyburide; Guanylate Cyclase; Guinea Pigs; Hypoglycemic Agents; Ileitis; Inflammation Mediators; KATP Channels; Lymphatic Vessels; Muscle Contraction; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Potassium Channels, Inwardly Rectifying; Quinoxalines; Receptors, Drug; Sulfonylurea Receptors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Transplantation of granulocytic myeloid-derived suppressor cells (G-MDSCs) could reduce colitis in experimental murine models.
Topics: Animals; Body Weight; Colitis; Cytokines; Disease Models, Animal; Female; Graft Survival; Granulocytes; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Myeloid Cells; Peroxidase; Trinitrobenzenesulfonic Acid | 2013 |
Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Hyperalgesia; Interleukin-2; Interleukin-6; Irritable Bowel Syndrome; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid | 2013 |
Early detection of renal injury using urinary vanin-1 in rats with experimental colitis.
Topics: Acetylglucosaminidase; Amidohydrolases; Animals; Biomarkers; Cell Adhesion Molecules; Chemokine CCL2; Colitis; Colon; Creatinine; Disease Models, Animal; Early Diagnosis; GPI-Linked Proteins; Kidney; Kidney Diseases; Kidney Function Tests; Male; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2014 |
Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Colitis; Cyclooxygenase 2; Disease Models, Animal; Male; Peroxidase; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Protein Binding; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid; Trinitrobenzenesulfonic Acid | 2013 |
Relevance of TNBS-colitis in rats: a methodological study with endoscopic, histologic and Transcriptomic [corrected] characterization and correlation to IBD.
Topics: Animals; Biopsy; Colonoscopy; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Rats; Reproducibility of Results; Transcriptome; Trinitrobenzenesulfonic Acid | 2013 |
Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Glutathione; Intestinal Mucosa; Mucins; Necrosis; Peroxidase; Phlomis; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2013 |
Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Disulfiram; Enzyme Inhibitors; Honey; Male; Nitric Oxide; Peroxidase; Prednisolone; Rats; Rats, Wistar; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2002 |
Compromised neuroimmune status in rats with experimental colitis.
Topics: Animals; Body Temperature; Circadian Rhythm; Colitis; Disease Models, Animal; Escherichia coli; Fever; Interleukin-6; Lipopolysaccharides; Male; Neuroimmunomodulation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease.
Topics: Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Down-Regulation; Gastrointestinal Agents; Male; Mice; Mice, Inbred BALB C; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide; Wasting Syndrome | 2003 |
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Colitis; Colon; Cytokines; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Naloxone; Narcotic Antagonists; Oligopeptides; Peroxidase; Receptors, Opioid, mu; Trinitrobenzenesulfonic Acid | 2003 |
Galectin-1 suppresses experimental colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Galectin 1; Gene Expression; Interferon-gamma; Interleukin-1; Interleukin-12; Mice; Mice, Inbred BALB C; Recombinant Proteins; Spleen; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
A novel diamino-pyridine derivative (IS-741) attenuates rat ileitis induced by trinitrobenzene sulfonic acid.
Topics: Animals; Disease Models, Animal; Ileitis; Immunohistochemistry; Male; Neutrophil Infiltration; Peroxidase; Phospholipases A; Pyridines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2003 |
Role of NK1.1+ and AsGm-1+ cells in oral immunoregulation of experimental colitis.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Asialoglycoprotein Receptor; Biomarkers; Biopsy, Needle; Colitis; Cytokines; Cytotoxicity, Immunologic; Disease Models, Animal; Flow Cytometry; Immune Tolerance; Immunohistochemistry; Killer Cells, Natural; Lectins, C-Type; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily B; Probability; Proteins; Random Allocation; Reference Values; Sensitivity and Specificity; Th1 Cells; Trinitrobenzenesulfonic Acid | 2003 |
Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria.
Topics: Administration, Oral; Administration, Rectal; Animals; Bacterial Translocation; Colitis; Colon; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Ileum; Immune System; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Lymph Nodes; Mice; Probiotics; RNA, Messenger; Safety; Species Specificity; Spleen; Stomach; Trinitrobenzenesulfonic Acid | 2003 |
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease.
Topics: Administration, Rectal; Animals; Antibodies, Bacterial; Bacteroides; Bacteroides Infections; Bifidobacterium; Coculture Techniques; Colitis; Disease Models, Animal; Germ-Free Life; Haptens; Immunoglobulin G; Immunoglobulin kappa-Chains; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Peanut Agglutinin; Peyer's Patches; Probiotics; Receptors, Mitogen; Species Specificity; Trinitrobenzenesulfonic Acid | 2003 |
Central effects of selective NK1 and NK3 tachykinin receptor agonists on two models of experimentally-induced colitis in rats.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Interleukin-1; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Survival Rate; Time Factors; Trinitrobenzenesulfonic Acid | 2003 |
Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Interferon-gamma; Interleukin-4; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Spleen; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2004 |
Glutathione supplementation improves oxidative damage in experimental colitis.
Topics: Animals; Chronic Disease; Colitis; Colon; Disease Models, Animal; Glutathione; Male; Oxidative Stress; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2003 |
The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Electrolytes; Ethanol; Female; Intestinal Mucosa; Phosphates; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solutions; Therapeutic Irrigation; Trinitrobenzenesulfonic Acid; Ulcer | 2003 |
Long-term evaluation of a rat model of chronic cholangitis resembling human primary sclerosing cholangitis.
Topics: Alanine Transaminase; Animals; Antibodies, Antineutrophil Cytoplasmic; C-Reactive Protein; Cholangitis, Sclerosing; Chronic Disease; Disease Models, Animal; Disease Progression; Female; Humans; Liver; Rats; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid | 2003 |
Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats.
Topics: Animals; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Peroxidase; Rats; Rats, Wistar; Schistosomiasis mansoni; Spleen; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2004 |
Tolerogenic APC generate CD8+ T regulatory cells that modulate pulmonary interstitial fibrosis.
Topics: Adoptive Transfer; Animals; Antigen-Presenting Cells; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Cell Division; Cells, Cultured; Dermatitis, Contact; Disease Models, Animal; Female; Haptens; Immune Tolerance; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Pulmonary Fibrosis; T-Lymphocyte Subsets; Transforming Growth Factor beta; Transforming Growth Factor beta2; Trinitrobenzenesulfonic Acid | 2004 |
Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats.
Topics: Acute Disease; Administration, Rectal; Animals; Colitis; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Ethanol; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Rectum; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2003 |
A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B.
Topics: Animals; Chronic Disease; Colitis; Collagen; Colon; Disease Models, Animal; Female; Fibrosis; Interferon-gamma; Matrix Metalloproteinase 1; Mice; Mice, Inbred BALB C; NF-kappa B; Oligonucleotides, Antisense; RNA, Messenger; Transcription Factor RelA; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
A mouse model of intestinal fibrosis?
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fibrosis; Mice; NF-kappa B; Oligonucleotides, Antisense; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2003 |
Contrasting roles for CXCR2 during experimental colitis.
Topics: Animals; Antibodies, Blocking; Chemokines, CXC; Colitis; Disease Models, Animal; Intercellular Signaling Peptides and Proteins; Male; Neutrophil Infiltration; Neutrophils; Rats; Rats, Wistar; Receptors, Interleukin-8B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2004 |
Imaging of intestinal lymphocyte homing by means of pinhole SPECT in a TNBS colitis mouse model.
Topics: Animals; Cell Movement; Colitis; Colon; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Lymphocytes; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxyquinoline; Radiopharmaceuticals; Receptors, Lymphocyte Homing; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Trinitrobenzenesulfonic Acid | 2004 |
The expression and role of Fas ligand in intestinal inflammation.
Topics: Animals; Blotting, Western; Colitis; Disease Models, Animal; Fas Ligand Protein; Gastrointestinal Transit; Guinea Pigs; Ileitis; Immunohistochemistry; Inflammation; Intestines; Male; Membrane Glycoproteins; Mice; Mice, Transgenic; Myenteric Plexus; Neutrophils; Trinitrobenzenesulfonic Acid | 2004 |
An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo.
Topics: Adult; Animals; Apoptosis; Cell Division; Cells, Cultured; Colitis; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Interferon-gamma; Interleukin-12; Interleukin-12 Subunit p40; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Middle Aged; Prospective Studies; Protein Subunits; Receptors, Interleukin; Receptors, Interleukin-12; Recombinant Fusion Proteins; Trinitrobenzenesulfonic Acid | 2004 |
Do vitamin E and selenium have beneficial effects on trinitrobenzenesulfonic acid-induced experimental colitis.
Topics: Animals; Antioxidants; Colitis, Ulcerative; Dietary Supplements; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Selenium; Trinitrobenzenesulfonic Acid; Vitamin E | 2004 |
Anti-inflammatory effect of diosmectite in hapten-induced colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Colitis; Cytokines; Disease Models, Animal; Female; Glutathione; Glycoproteins; Haptens; Humans; Interleukin-1; Interleukin-1beta; Intestinal Mucosa; Leukotriene B4; Mucins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Wistar; Silicates; Trinitrobenzenesulfonic Acid | 2004 |
1,8-cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitis.
Topics: Acute Disease; Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Eucalyptol; Glutathione; Instillation, Drug; Intestinal Mucosa; Male; Monoterpenes; Organ Size; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Yersinia pseudotuberculosis anti-inflammatory components reduce trinitrobenzene sulfonic acid-induced colitis in the mouse.
Topics: Animals; Colitis; Disease Models, Animal; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Yersinia pseudotuberculosis; Yersinia pseudotuberculosis Infections | 2004 |
Reduction of Smad3 accelerates re-epithelialization in a murine model of colitis.
Topics: Animals; Cell Division; Colitis; Disease Models, Animal; DNA-Binding Proteins; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Regeneration; Severity of Illness Index; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Wound Healing | 2004 |
Expression of apoptosis-related proteins in rat with induced colitis.
Topics: Animals; Antigens, Surface; Apoptosis; Biomarkers; Biopsy; Colitis; Disease Models, Animal; Fas Ligand Protein; fas Receptor; In Situ Nick-End Labeling; Ligands; Male; Membrane Glycoproteins; Rats; Rats, Wistar; Transglutaminases; Trinitrobenzenesulfonic Acid; Tumor Suppressor Protein p53 | 2004 |
The role of intrahepatic CD8+ T cell trapping and NK1.1+ cells in liver-mediated immune regulation.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immune Tolerance; Killer Cells, Natural; Lectins, C-Type; Liver; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily B; Proteins; Trinitrobenzenesulfonic Acid | 2004 |
Intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalanthus bromelioides, in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Antioxidants; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Eriocaulaceae; Female; Gastrointestinal Agents; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglionic Blockers; Hexamethonium; Hypothalamo-Hypophyseal System; Injections, Intraventricular; Intestinal Mucosa; Male; Mifepristone; Neurotransmitter Agents; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Restraint, Physical; Stress, Physiological; Sympathetic Nervous System; Trinitrobenzenesulfonic Acid | 2004 |
The effect of recombinant human growth hormone (rhGH) on trinitrobenzene sulfonic acid-induced colitis in rats: an experimental study.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Colitis, Ulcerative; Disease Models, Animal; Human Growth Hormone; Immunohistochemistry; Intestinal Mucosa; Male; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Sensitivity and Specificity; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid | 2004 |
Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis.
Topics: 1-Deoxynojirimycin; Adamantane; Animals; Anti-Inflammatory Agents; Antibodies; Body Weight; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Glycolipids; Haptens; Immunoglobulin G; Immunosuppressive Agents; Interferon-gamma; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Oxazolone; Peroxidase; Trinitrobenzenesulfonic Acid | 2004 |
Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine.
Topics: Animals; Body Weight; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Intestinal Mucosa; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1; Venules | 2004 |
Colitis up-regulates local glucocorticoid activation and down-regulates inactivation in colonic tissue.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Colitis, Ulcerative; Corticosterone; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Male; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2004 |
The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis.
Topics: Animals; Antibodies; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Colitis; Colon; Disease Models, Animal; Macrophage Inflammatory Proteins; Male; Neutrophil Infiltration; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2004 |
Pharmacological properties of traditional medicine (XXIX): effect of Hange-shashin-to and the combinations of its herbal constituents on rat experimental colitis.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Colitis; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Male; Peptic Ulcer; Phytotherapy; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Angiotensin II mediates acinar cell apoptosis during the development of rat pancreatic fibrosis by AT1R.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Disease Models, Animal; Fibrosis; Gene Expression Regulation; In Situ Nick-End Labeling; Losartan; Male; Pancreas; Pancreatic Ducts; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2004 |
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Administration, Rectal; Anesthetics, Local; Animals; Bupivacaine; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Injections, Subcutaneous; Lidocaine; Male; Organ Size; Rats; Rats, Sprague-Dawley; Trimebutine; Trinitrobenzenesulfonic Acid | 2004 |
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Topics: Adult; Animals; B-Lymphocytes; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peptide Fragments; Permeability; Peroxidase; Receptor, PAR-1; RNA, Messenger; Survival Rate; T-Lymphocytes; Thrombin; Trinitrobenzenesulfonic Acid | 2004 |
Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats.
Topics: Animals; Body Weight; Colitis; Disease Models, Animal; Female; Intestinal Mucosa; Lipid Peroxidation; Nitric Oxide Synthase; Rats; Rats, Wistar; Restraint, Physical; Trinitrobenzenesulfonic Acid | 2004 |
Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trinitrobenzene sulfonic acid.
Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Inflammation; Intestinal Mucosa; Male; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2004 |
Selective loss of NGF-sensitive neurons following experimental colitis.
Topics: Animals; Biomarkers; Calbindins; Cell Count; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; Male; Nerve Growth Factor; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; S100 Calcium Binding Protein G; Trinitrobenzenesulfonic Acid | 2005 |
Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten.
Topics: Adjuvants, Immunologic; Administration, Oral; Animal Feed; Animals; Antigens; Colitis; Colon; Disease Models, Animal; Haptens; Interleukin-10; Male; Mice; Monocytes; Oxazolone; Picrates; Proteins; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2005 |
Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitis.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Female; Glatiramer Acetate; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Peptides; Polymers; Severity of Illness Index; Survival Analysis; Trinitrobenzenesulfonic Acid | 2005 |
Disturbances in epithelial ionic secretion in different experimental models of colitis.
Topics: Acetic Acid; Acute Disease; Alkylating Agents; Animals; Animals, Genetically Modified; Chloramines; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; HLA-B27 Antigen; Indicators and Reagents; Iodoacetamide; Ions; Oxazolone; Patch-Clamp Techniques; Rats; Trinitrobenzenesulfonic Acid | 2005 |
The presentation of haptenated proteins and activation of T cells in the mesenteric lymph nodes by dendritic cells in the TNBS colitis rat.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Haptens; Inflammatory Bowel Diseases; Lymph Nodes; Rats; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2004 |
An improved and reliable method for the induction of colitis in rats using 2,4,6-trinitrobenzene sulfonic acid.
Topics: Animals; Colitis; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Ulcer; Wound Healing | 2005 |
Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease.
Topics: Animals; Crohn Disease; Cytokines; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Female; Imidazoles; Immunoblotting; Inflammation; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Models, Biological; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Kinases; Pyridines; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Subcellular Fractions; Trinitrobenzenesulfonic Acid; Up-Regulation | 2005 |
Preventative effects of lactulose in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Colitis; Disease Models, Animal; Female; Gastrointestinal Agents; Lactobacillaceae; Lactulose; Leukotriene B4; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Disease Models, Animal; Male; Metronidazole; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tylosin | 2005 |
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Male; Mesocricetus; Oxadiazoles; Prednisolone; Pyrimidinones; Random Allocation; Trinitrobenzenesulfonic Acid | 2005 |
Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig.
Topics: Adaptation, Physiological; Animals; Colitis; Colon; Disease Models, Animal; Excitatory Postsynaptic Potentials; Guinea Pigs; Intestinal Mucosa; Male; Neurons; Submucous Plexus; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2005 |
A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis.
Topics: Animals; Body Weight; Colitis; Disease Models, Animal; Eating; Edema; Enzyme Inhibitors; Female; Group II Phospholipases A2; Humans; Hypertension; Inflammatory Bowel Diseases; Lipopolysaccharides; Neutropenia; Pentanoic Acids; Peroxidase; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Differential role of tumor necrosis factor receptors in TNBS colitis.
Topics: Animals; Colitis; Disease Models, Animal; Hypothermia; Mice; Mice, Inbred C57BL; Mortality; Receptors, Tumor Necrosis Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss | 2005 |
Effects of hepatocyte growth factor on rat inflammatory bowel disease models.
Topics: Animals; Apoptosis; Cell Proliferation; Colon; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Hepatocyte Growth Factor; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mitogens; Rats; Rats, Wistar; Recombinant Proteins; Regeneration; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2005 |
The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Colitis; Collagen; Colon; Disease Models, Animal; Enzyme Inhibitors; Female; Glutathione; Lisinopril; Male; Malondialdehyde; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Gene Expression Regulation; Immunoglobulins; Interleukin-1; Interleukin-8; Lymphotoxin beta Receptor; Lymphotoxin-alpha; Male; Membrane Proteins; Mesalamine; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 14; Receptors, Virus; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor-alpha | 2005 |
Effects of acupuncture at GV01 on experimentally induced colitis in rats: possible involvement of the opioid system.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
Mucosal colonisation with Lactobacillus casei mitigates barrier injury induced by exposure to trinitronbenzene sulphonic acid.
Topics: Animals; Bacterial Translocation; Colitis, Ulcerative; Colon; Disease Models, Animal; Intestinal Absorption; Intestinal Mucosa; Lacticaseibacillus casei; Liver; Lymph Nodes; Male; Peroxidase; Probiotics; Rats; Rats, Sprague-Dawley; Spleen; Trinitrobenzenesulfonic Acid | 2005 |
Protective effect of hawthorn fruit on murine experimental colitis.
Topics: Acute Disease; Animals; Anticoagulants; Colitis; Crataegus; Dextran Sulfate; Disease Models, Animal; Female; Fruit; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Preparations; Trinitrobenzenesulfonic Acid | 2005 |
Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and matrix metalloproteinase activity.
Topics: Acremonium; Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Ergot Alkaloids; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Indole Alkaloids; Inflammation; Lymph Nodes; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Th1 Cells; Trinitrobenzenesulfonic Acid | 2005 |
Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis.
Topics: Analysis of Variance; Animals; Colitis; Colony Count, Microbial; Disease Models, Animal; Fatty Acids, Volatile; Female; Glutathione; Inflammation Mediators; Intestinal Mucosa; Leukotriene B4; Limosilactobacillus fermentum; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Enterochromaffin Cells; Immunohistochemistry; Intestinal Mucosa; Mast Cells; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2005 |
Thromboxane A2 up-regulates neutrophil elastase release in Syrian hamsters with trinitrobenzene sulfonic acid-induced colitis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Colitis; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Leukotriene B4; Male; Mesocricetus; Specific Pathogen-Free Organisms; Thromboxane A2; Trinitrobenzenesulfonic Acid; Up-Regulation | 2005 |
Molecular and behavioral changes in nociception in a novel rat model of chronic pancreatitis for the study of pain.
Topics: Amylases; Animals; Behavior, Animal; Calcitonin Gene-Related Peptide; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Radiation; Electric Stimulation; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Gene Expression Regulation; Immunohistochemistry; Male; Nerve Growth Factor; Nociceptors; Pain; Pain Measurement; Pancreatitis; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Substance P; Time Factors; Trinitrobenzenesulfonic Acid | 2005 |
Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children.
Topics: Animals; Antibodies; Case-Control Studies; Child; Colitis; Crohn Disease; Disease Models, Animal; Genotype; Growth Disorders; Humans; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Intestinal Diseases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2005 |
Spinal cord stimulation attenuates visceromotor reflexes in a rat model of post-inflammatory colonic hypersensitivity.
Topics: Animals; Colitis; Disease Models, Animal; Electric Stimulation Therapy; Gastrointestinal Motility; Inflammation; Male; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Trinitrobenzenesulfonic Acid | 2005 |
Role of tumor necrosis factor receptors in an animal model of acute colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; E-Selectin; Female; Gene Expression; Intercellular Adhesion Molecule-1; Intestine, Small; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2005 |
Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2.
Topics: Animals; Azoxymethane; beta Catenin; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Disease Susceptibility; Intramolecular Oxidoreductases; Lipocalins; Male; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Trinitrobenzenesulfonic Acid | 2005 |
Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Intestinal Mucosa; Male; Melatonin; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Matrines; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Quinolizines; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Treatment with Met-RANTES decreases bacterial translocation in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Translocation; Chemokine CCL5; Colitis; Colon; Disease Models, Animal; Male; Noxae; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Therapeutic effect of urocortin and adrenomedullin in a murine model of Crohn's disease.
Topics: Adrenomedullin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Chemokines; Corticotropin-Releasing Hormone; Crohn Disease; Cytokines; Disease Models, Animal; Interleukin-10; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Peptides; Proteins; Th1 Cells; Trinitrobenzenesulfonic Acid; Urocortins | 2006 |
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
Topics: Adult; Aged; Amidohydrolases; Animals; Arachidonic Acids; Benzenesulfonates; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Endocannabinoids; Female; Glycerides; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mesalamine; Mice; Mice, Inbred C57BL; Middle Aged; Peroxidase; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Specific Pathogen-Free Organisms; Trinitrobenzenesulfonic Acid | 2006 |
Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Myenteric Plexus; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Trinitrobenzenesulfonic Acid; Up-Regulation; Visceral Afferents | 2006 |
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hydroxamic Acids; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neutrophils; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Trinitrobenzenesulfonic Acid; Up-Regulation | 2006 |
A combination of peppermint oil and caraway oil attenuates the post-inflammatory visceral hyperalgesia in a rat model.
Topics: Administration, Rectal; Animals; Colon; Disease Models, Animal; Drug Therapy, Combination; Ethanol; Hyperalgesia; Male; Mentha piperita; Nociceptors; Oils, Volatile; Parasympatholytics; Plant Oils; Rats; Rats, Inbred Lew; Treatment Outcome; Trinitrobenzenesulfonic Acid; Viscera | 2006 |
Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects.
Topics: Animals; Colitis; Disease Models, Animal; Female; Lactobacillus plantarum; Lactococcus lactis; Mice; Mice, Inbred BALB C; Probiotics; Reproducibility of Results; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2006 |
Cortistatin, an antiinflammatory peptide with therapeutic action in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cytokines; Disease Models, Animal; Humans; Immunity, Mucosal; In Vitro Techniques; Inflammation Mediators; Inflammatory Bowel Diseases; Macrophages; Mice; Mice, Inbred BALB C; Neuropeptides; Th1 Cells; Trinitrobenzenesulfonic Acid | 2006 |
Psychological stress and the severity of post-inflammatory visceral hyperalgesia.
Topics: Abdominal Muscles; Acute Disease; Animals; Avoidance Learning; Behavior, Animal; Colon; Dilatation; Disease Models, Animal; Drinking Behavior; Electromyography; Ethanol; Female; Hyperalgesia; Inflammation; Interleukin-2; Pain Threshold; Rats; Rats, Inbred Lew; Rectum; Severity of Illness Index; Solvents; Stress, Psychological; Trinitrobenzenesulfonic Acid; Viscera; Visceral Afferents | 2007 |
Intestinal 5-hydroxytryptamine and mast cell infiltration in rat experimental colitis.
Topics: Analysis of Variance; Animals; Cell Movement; Colitis, Ulcerative; Confidence Intervals; Dexamethasone; Disease Models, Animal; Ethanol; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Male; Mast Cells; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity; Serotonin; Trinitrobenzenesulfonic Acid | 2006 |
Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Immunohistochemistry; Intestinal Mucosa; Leukocytes; Male; Microcirculation; Nitrobenzenes; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Regional Blood Flow; Sensitivity and Specificity; Sulfonamides; Tissue Adhesions; Trinitrobenzenesulfonic Acid | 2006 |
[Correlation of intestinal mucosal injury with serum diamine oxidase].
Topics: Amine Oxidase (Copper-Containing); Animals; Biomarkers; Colitis; Disease Models, Animal; Enema; Immunohistochemistry; Intestinal Mucosa; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Spectrophotometry; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model.
Topics: Abdominal Muscles; Acute Disease; Animals; Catheterization; Colitis; Colon; Dilatation, Pathologic; Disease Models, Animal; Electromyography; Enzyme-Linked Immunosorbent Assay; Hyperalgesia; Interleukin-2; Interleukin-6; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Rats; Rats, Inbred Lew; Rectum; Sensation Disorders; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis.
Topics: Action Potentials; Afferent Pathways; Animals; Disease Models, Animal; Ganglia, Spinal; Ion Channel Gating; Male; Membrane Potentials; Pain; Pancreatitis, Chronic; Posterior Horn Cells; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2006 |
Contractile activity of lymphatic vessels is altered in the TNBS model of guinea pig ileitis.
Topics: Animals; Disease Models, Animal; Guinea Pigs; Ileitis; Lymphatic Vessels; Male; Muscle Contraction; Muscle, Smooth; Prostaglandin-Endoperoxide Synthases; Trinitrobenzenesulfonic Acid | 2006 |
Anti-inflammatory potential of the probiotic dietary supplement Lactibiane Tolérance: in vitro and in vivo considerations.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Cells, Cultured; Colitis; Cytokines; Dietary Supplements; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Lactobacillus; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Probiotics; Random Allocation; Severity of Illness Index; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2006 |
GITR modulates innate and adaptive mucosal immunity during the development of experimental colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis, Ulcerative; Disease Models, Animal; Gene Deletion; Gene Expression; Glucocorticoid-Induced TNFR-Related Protein; Immunity, Innate; Immunity, Mucosal; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Leukocyte Common Antigens; Ligands; Mice; Mice, SCID; Polymerase Chain Reaction; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Spleen; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2007 |
Role of TNF-alpha in muscularis inflammation and motility disorder in a TNBS-induced colitis model: clues from TNF-alpha-deficient mice.
Topics: Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Inflammation; Interleukin-1; Interleukin-6; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Peroxidase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Antioxidant treatment with taurine ameliorates chronic pancreatitis in an experimental rat model.
Topics: Animals; Antioxidants; Body Weight; Disease Models, Animal; Fibrosis; Glutathione Peroxidase; Male; Malondialdehyde; Oxidative Stress; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Taurine; Trinitrobenzenesulfonic Acid | 2006 |
Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition.
Topics: Animals; Blotting, Western; Carbachol; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gastrointestinal Motility; Isometric Contraction; Male; Malondialdehyde; Meloxicam; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peroxidase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazines; Thiazoles; Trinitrobenzenesulfonic Acid | 2006 |
No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases.
Topics: Adult; Animals; Blotting, Western; Colitis, Ulcerative; Disease Models, Animal; Enzyme Inhibitors; Female; Gene Expression; Humans; Imidazoles; Inflammatory Bowel Diseases; Interleukin-1; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; Male; Mice; Mice, Inbred BALB C; Middle Aged; p38 Mitogen-Activated Protein Kinases; Polymerase Chain Reaction; Prognosis; Pyridines; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Endothelin-1 receptor antagonist (LU-135252) improves the microcirculation and course of TNBS colitis in rats.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Colitis; Colon; Disease Models, Animal; Endothelin A Receptor Antagonists; Male; Microcirculation; Phenylpropionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2006 |
Intestinal antiinflammatory activity of a lyophilized infusion of Turnera ulmifolia in TNBS rat colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freeze Drying; Gastrointestinal Agents; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Turnera | 2006 |
Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Colitis; Dendritic Cells; Disease Models, Animal; Lymph Nodes; Macrophages; Mice; Toll-Like Receptor 2; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2006 |
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Colitis; Disease Models, Animal; Free Radicals; Gene Expression Regulation; Glutathione Peroxidase; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2006 |
Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Colitis; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression; Male; Myenteric Plexus; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Non-viral delivery of nuclear factor-kappaB decoy ameliorates murine inflammatory bowel disease and restores tissue homeostasis.
Topics: Animals; Colon; Dextran Sulfate; Disease Models, Animal; Female; Gene Transfer Techniques; Genetic Therapy; Homeostasis; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microscopy, Confocal; NF-kappa B; Oligodeoxyribonucleotides; Oxazolone; Trinitrobenzenesulfonic Acid | 2007 |
Selecting lactic acid bacteria for their safety and functionality by use of a mouse colitis model.
Topics: Acute Disease; Animals; Bacterial Adhesion; Caco-2 Cells; Colitis; Disease Models, Animal; Female; Gastrointestinal Tract; Humans; In Vitro Techniques; Lactobacillus; Mice; Mice, Inbred BALB C; Probiotics; Safety; Trinitrobenzenesulfonic Acid | 2006 |
Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross-talk.
Topics: Action Potentials; Animals; Colon; Cystitis, Interstitial; Disease Models, Animal; Ganglia, Spinal; Immunohistochemistry; Inflammation; Irritable Bowel Syndrome; Male; Neurons; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Urinary Bladder | 2006 |
Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets.
Topics: Animals; Biomarkers; Colitis; Disease Models, Animal; Electronic Data Processing; Female; Gene Expression Profiling; Inflammation Mediators; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2006 |
Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Motility; Gene Expression; Haptens; Immunohistochemistry; Inflammation; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Peroxidase; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines.
Topics: Animals; Body Weight; Chemotaxis, Leukocyte; Colitis; Colon; Disease Models, Animal; Eating; Female; Interleukin-10; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Up-Regulation | 2006 |
Antibodies to complement receptor 3 treat established inflammation in murine models of colitis and a novel model of psoriasiform dermatitis.
Topics: Adoptive Transfer; Animals; Antibodies; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dermatitis; Disease Models, Animal; Female; Inflammation Mediators; Injections, Intravenous; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Psoriasis; Trinitrobenzenesulfonic Acid | 2006 |
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotides, Antisense; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2006 |
Therapeutic treatment of experimental colitis with regulatory dendritic cells generated with vasoactive intestinal peptide.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Transplantation; Cells, Cultured; Colitis; Dendritic Cells; Disease Models, Animal; Immune Tolerance; Immunotherapy; Interleukin-10; Mice; Mice, Inbred BALB C; Th1 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2006 |
Glucocorticoid-induced tumour necrosis factor receptor family-related receptor signalling exacerbates hapten-induced colitis by CD4+ T cells.
Topics: Animals; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Female; Glucocorticoid-Induced TNFR-Related Protein; Haptens; Immunity, Mucosal; Immunoglobulin A; Immunoglobulin G; Inflammatory Bowel Diseases; Intestinal Mucosa; Lymph Nodes; Mice; Mice, Inbred BALB C; Receptors, Nerve Growth Factor; Receptors, Tumor Necrosis Factor; Signal Transduction; Trinitrobenzenesulfonic Acid | 2006 |
[Effect of emodin on pancreatic fibrosis: experiment with rats].
Topics: Animals; Blotting, Western; Collagen; Disease Models, Animal; Dose-Response Relationship, Drug; Emodin; Fibrosis; Hyaluronic Acid; Laminin; Male; Pancreas; Pancreatic Diseases; Phytotherapy; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2006 |
Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression; Inflammatory Bowel Diseases; Leukocyte Common Antigens; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotide Array Sequence Analysis; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2007 |
Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Humans; Lactobacillus; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Probiotics; Trinitrobenzenesulfonic Acid | 2007 |
Adiponectin deficiency protects mice from chemically induced colonic inflammation.
Topics: Adiponectin; Animals; Chemokine CXCL2; Chemokines; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-6; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Receptors, Adiponectin; Receptors, Cell Surface; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Intestinal inflammation downregulates smooth muscle CPI-17 through induction of TNF-alpha and causes motility disorders.
Topics: Animals; Carbachol; Disease Models, Animal; Down-Regulation; Escin; Gastrointestinal Motility; Ileitis; Interleukin-1beta; Intestinal Diseases; Intracellular Signaling Peptides and Proteins; Male; Mice; Muscle Proteins; Muscle, Smooth; Phosphoproteins; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Corticosterone; Dextran Sulfate; Disease Models, Animal; Estradiol; Estrous Cycle; Female; Gonadal Steroid Hormones; Immunohistochemistry; Interleukin-1beta; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Ovariectomy; Peroxidase; Progesterone; Rats; Rats, Wistar; Severity of Illness Index; Sex Factors; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Chronic administration of galanin attenuates the TNBS-induced colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Galanin; Injections, Intraperitoneal; Male; Mast Cells; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Granulocytes; Hydrogen Sulfide; Mesalamine; Mice; Mice, Inbred BALB C; RNA, Messenger; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.
Topics: Animals; Colitis; Colon; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Electric Stimulation; Enzyme Activation; Evoked Potentials; Excitatory Postsynaptic Potentials; Guinea Pigs; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Electron, Transmission; Myenteric Plexus; Neuronal Plasticity; Peptides; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase Inhibitors; Sulfonamides; Synaptic Transmission; Synaptic Vesicles; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
PARP inhibition reduces acute colonic inflammation in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Agents; Isoquinolines; Membrane Proteins; Niacinamide; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
The role of adiponectin in colitis.
Topics: Adiponectin; Animals; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Interleukin-8; Intestinal Mucosa; Mice; Research Design; Trinitrobenzenesulfonic Acid | 2007 |
Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats.
Topics: Animals; Colitis; Disease Models, Animal; Female; Mast Cells; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stem Cell Factor; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urination | 2007 |
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2.
Topics: Animals; Anti-Inflammatory Agents; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Enteric Nervous System; Glucagon-Like Peptide 2; Ileitis; Male; Neurotensin; Rats; Rats, Sprague-Dawley; Recombinant Fusion Proteins; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2007 |
Chemically induced mouse models of intestinal inflammation.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2007 |
R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Mice; Mice, Inbred BALB C; Mitogens; Piroxicam; Plasma Substitutes; Recombinant Proteins; Severity of Illness Index; Thrombospondins; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2007 |
Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities.
Topics: Acridines; Animals; Antioxidants; Colitis; Collagen; Colon; Disease Models, Animal; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Expectorants; Female; Free Radical Scavengers; Glutathione; Luminescence; Luminol; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thioglycolates; Thiophenes; Trinitrobenzenesulfonic Acid | 2007 |
Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chemokines; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Acid; Nitric Oxide Synthase Type II; Trinitrobenzenesulfonic Acid | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis.
Topics: Animals; Anti-Ulcer Agents; Colitis; Colon; Cytokines; Dendritic Cells; Dinoprostone; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-12; Interleukin-17; Interleukin-23; Interleukins; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Misoprostol; Neutrophils; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2007 |
The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Malondialdehyde; Oxidative Stress; Radioimmunoassay; Rats; Restraint, Physical; Severity of Illness Index; Stress, Physiological; Substance P; Trinitrobenzenesulfonic Acid | 2008 |
15-deoxyspergualin prevents mucosal injury by inhibiting production of TNF-alpha and down-regulating expression of MD-1 in a murine model of TNBS-induced colitis.
Topics: Administration, Rectal; Animals; Antigens, CD19; Antigens, Surface; Apoptosis; B-Lymphocytes; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Down-Regulation; Female; Guanidines; Immunosuppressive Agents; Injections, Intraperitoneal; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Toll-Like Receptors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis.
Topics: Animals; Colitis; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Gastrointestinal Tract; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Urocortins | 2007 |
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arterioles; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Enteric Nervous System; Guanethidine; Intestinal Mucosa; Male; Mice; Microscopy, Video; Norepinephrine; Phenylephrine; Prazosin; Purinergic P2 Receptor Antagonists; Receptors, Adrenergic, alpha-1; Receptors, Purinergic P2; Receptors, Purinergic P2X; Suramin; Sympathetic Nervous System; Tetrodotoxin; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation; Vasoconstriction | 2007 |
Phenotypic changes of morphologically identified guinea-pig myenteric neurons following intestinal inflammation.
Topics: Action Potentials; Animals; Disease Models, Animal; Guinea Pigs; Ileitis; Ileum; Intermediate-Conductance Calcium-Activated Potassium Channels; Myenteric Plexus; Neurons; Phenotype; Potassium Channel Blockers; Pyrazoles; Synaptic Transmission; Tetrodotoxin; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein.
Topics: Administration, Oral; Animals; Antigens, Bacterial; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Interleukin-10; Intestinal Mucosa; Lactococcus lactis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Pore Forming Cytotoxic Proteins; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid | 2007 |
[The role of the serotoninergic system in the pathogenesis of experimental ulcerous colitis].
Topics: Animals; Colitis, Ulcerative; Disease Models, Animal; Dopamine Antagonists; Rats; Rats, Wistar; Serotonin; Spiperone; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2007 |
Transient receptor potential vanilloid 1 mediates hyperalgesia and is up-regulated in rats with chronic pancreatitis.
Topics: Anilides; Animals; Behavior, Animal; Capsaicin; Cinnamates; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; Hyperalgesia; Male; Membrane Potentials; Pain Measurement; Pain Threshold; Pancreas; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation | 2007 |
Regional difference in the healing process of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Topics: Animals; Colitis; Colon; Dinoprostone; Disease Models, Animal; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2007 |
Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Touch; Trinitrobenzenesulfonic Acid; Viscera; Visceral Afferents | 2008 |
Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; I-kappa B Kinase; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Peptides; Trinitrobenzenesulfonic Acid | 2007 |
The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
Topics: Animals; Capsaicin; Colitis; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Electromyography; Ganglia, Spinal; Gastrointestinal Motility; Hyperalgesia; Male; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; Sulfonamides; Thiourea; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Visceral Afferents | 2007 |
The therapeutic effect of glatiramer acetate in a murine model of inflammatory bowel disease is mediated by anti-inflammatory T-cells.
Topics: Adoptive Transfer; Animals; Dextran Sulfate; Disease Models, Animal; Glatiramer Acetate; Humans; Immunohistochemistry; Immunologic Factors; Inflammatory Bowel Diseases; Interleukin-10; Mice; Mice, Inbred C57BL; Peptides; Spleen; T-Lymphocytes, Regulatory; Th2 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2007 |
The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Colon; Crohn Disease; Disease Models, Animal; Female; Glutathione; Interferon-gamma; Leukotriene B4; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Salicylates; Spleen; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Inflammation and inflammatory agents activate protein kinase C epsilon translocation and excite guinea-pig submucosal neurons.
Topics: Action Potentials; Animals; Blotting, Western; Calbindin 2; Cell Membrane; Cytoplasm; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Activators; Guinea Pigs; Ileitis; Ileum; In Vitro Techniques; Inflammation Mediators; Kinetics; Neuropeptide Y; Oligopeptides; Peptide Fragments; Phorbol 12,13-Dibutyrate; Protein Kinase C-epsilon; Protein Transport; Receptor, PAR-2; Receptors, Neurokinin-3; S100 Calcium Binding Protein G; Signal Transduction; Submucous Plexus; Substance P; Trinitrobenzenesulfonic Acid; Trypsin; Vasoactive Intestinal Peptide | 2007 |
Altered protein profile of lymphocytes in an antigen-specific model of colitis: a comparative proteomic study.
Topics: Animals; Apoptosis; Blood Proteins; Colitis; Disease Models, Animal; Lymphocyte Activation; Lymphocytes; Male; Oxidative Stress; Proteomics; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trinitrobenzenesulfonic Acid | 2007 |
5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Survival; Chemistry, Pharmaceutical; Colitis; Colon; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Feasibility Studies; Gastrointestinal Agents; Humans; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Particle Size; Peroxidase; Polyesters; Solubility; Technology, Pharmaceutical; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
A comparative study of the preventative effects exerted by three probiotics, Bifidobacterium lactis, Lactobacillus casei and Lactobacillus acidophilus, in the TNBS model of rat colitis.
Topics: Animals; Bifidobacterium; Colitis, Ulcerative; Diarrhea; Disease Models, Animal; Feces; Female; Lacticaseibacillus casei; Lactobacillus acidophilus; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2007 |
Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile.
Topics: Animals; Anti-Inflammatory Agents; Calcitriol; Calcium; Cell Differentiation; Colitis; Colon; Creatinine; Cytokines; Dexamethasone; Disease Models, Animal; Glucocorticoids; Immunologic Factors; Male; Mice; Mice, Inbred BALB C; Peroxidase; T-Lymphocytes; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2008 |
Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Glutathione; Ileitis; Ileum; Lipid Peroxidation; Malondialdehyde; Neutrophil Infiltration; Neutrophils; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid; Trinitrobenzenesulfonic Acid | 2007 |
Effect of heme oxygenase-1 induction by octreotide on TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Blotting, Western; Colitis, Ulcerative; Colon; Disease Models, Animal; Enzyme Induction; Gastrointestinal Agents; Glutathione; Heme Oxygenase (Decyclizing); Male; Malondialdehyde; NF-kappa B; Octreotide; Oxidative Stress; Rats; Rats, Wistar; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
[Studies on the influence of Candida fungal colonization on the healing process of inflammatory lesions in the colon in rat animal model].
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Candidiasis; Disease Models, Animal; Fluconazole; Inflammatory Bowel Diseases; Interleukin-1beta; Male; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Wound Healing | 2007 |
The effect of the cholinergic anti-inflammatory pathway on experimental colitis.
Topics: Anabasine; Animals; Blotting, Western; Chlorisondamine; Cholinergic Agonists; Colitis; Disease Models, Animal; Inflammation; Male; Mice; NF-kappa B; Nicotinic Antagonists; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2008 |
Indomethacin and retinoic acid modify mouse intestinal inflammation and fibrosis: a role for SPARC.
Topics: Animals; Crohn Disease; Disease Models, Animal; Female; Fibrosis; Immunoenzyme Techniques; Indomethacin; Mice; Osteonectin; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; RNA; Statistics, Nonparametric; Tretinoin; Trinitrobenzenesulfonic Acid | 2008 |
Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis.
Topics: Animals; Antioxidants; Catechin; Colitis; Cytokines; Disease Models, Animal; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Peroxidase; Tea; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2008 |
Role of Ca2+-sensitization in attenuated carbachol-induced contraction of the colon in a rat model of colitis.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Colitis; Colon; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Trinitrobenzenesulfonic Acid | 2008 |
Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine models.
Topics: Animals; Antibiosis; Cell-Free System; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Female; Food Microbiology; Humans; Hydrogen-Ion Concentration; Lactobacillus plantarum; Leukocytes, Mononuclear; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Probiotics; Salmonella Infections; Streptococcus; Trinitrobenzenesulfonic Acid | 2008 |
Hind paw incision in the rat produces long-lasting colon hypersensitivity.
Topics: Animals; Colitis; Disease Models, Animal; Hindlimb; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors; Trinitrobenzenesulfonic Acid; Viscera | 2008 |
Allopurinol in rat chronic pancreatitis: effects on pancreatic stellate cell activation.
Topics: Actins; Allopurinol; Animals; Antioxidants; Atrophy; Collagen; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Immunohistochemistry; Male; Oxidative Stress; Pancreas; Pancreatitis, Chronic; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid; Xanthine Oxidase | 2007 |
Glucocorticoid availability in colonic inflammation of rat.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Budesonide; Carbenoxolone; Colitis; Colon; Corticosterone; Cyclooxygenase 2; Disease Models, Animal; Glucocorticoids; Hormone Antagonists; Interleukin-1beta; Male; Mifepristone; Mucin-2; Mucins; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.
Topics: Administration, Oral; Animals; Benzothiazoles; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Enzyme Inhibitors; Epoxide Hydrolases; Inflammation; Interleukin-6; Male; Peroxidase; Piperidines; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease.
Topics: Animals; Cell Membrane Permeability; Colitis; Colon; Cytokines; Disease Models, Animal; Feces; Immunity; Inflammatory Bowel Diseases; Interleukin-10; Lactobacillus; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Probiotics; Trinitrobenzenesulfonic Acid | 2008 |
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Colitis; Crohn Disease; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Susceptibility; Down-Regulation; Immunity, Innate; Interferon Regulatory Factors; Ligands; Mice; Mice, Mutant Strains; Nod2 Signaling Adaptor Protein; RNA, Small Interfering; Toll-Like Receptors; Trinitrobenzenesulfonic Acid | 2008 |
Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent.
Topics: Animals; Colitis; Concanavalin A; Curcumin; Diet; Disease Models, Animal; Inflammatory Bowel Diseases; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Microarray Analysis; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Trinitrobenzenesulfonic Acid | 2008 |
Anti-inflammatory properties of lactic acid bacteria producing superoxide dismutase.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Interleukin-10; Lactobacillus; Mice; Mice, Knockout; Probiotics; Reactive Oxygen Species; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2008 |
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blotting, Western; Colitis; Disease Models, Animal; Heme Oxygenase-1; Male; Mesalamine; Peroxidase; Protoporphyrins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Abolishment of TNBS-induced visceral hypersensitivity in mast cell deficient rats.
Topics: Animals; Colon; Disease Models, Animal; Hyperalgesia; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mast Cells; Necrosis; Pain Threshold; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2008 |
The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat.
Topics: Administration, Rectal; Animals; Antioxidants; Colitis; Colitis, Ulcerative; Colon; Dexamethasone; Disease Models, Animal; Ethanol; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Oils, Volatile; Origanum; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Impaired acetylcholine-induced smooth muscle contraction in colitis involves altered calcium mobilization and AKT phosphorylation.
Topics: Acetylcholine; Animals; Blotting, Western; Calcium Signaling; Colitis; Colon; Disease Models, Animal; Male; Microscopy, Fluorescence; Microscopy, Video; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Effect of taurine on oxidative stress and apoptosis-related protein expression in trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-2-Associated X Protein; Blotting, Western; Colitis, Ulcerative; Colon; Disease Models, Animal; Glutathione; Male; Malondialdehyde; Oxidative Stress; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Taurine; Trinitrobenzenesulfonic Acid | 2008 |
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; CD30 Ligand; Colitis; Cytokines; Disease Models, Animal; Genetic Predisposition to Disease; Inflammatory Bowel Diseases; Interleukin-4; Intestinal Mucosa; Ki-1 Antigen; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Oxazolone; Signal Transduction; Trinitrobenzenesulfonic Acid | 2008 |
Subcutaneous adipose tissue-derived stem cells facilitate colonic mucosal recovery from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats.
Topics: Adiponectin; Adipose Tissue; Animals; Cell Differentiation; Colon; Crohn Disease; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Hepatocyte Growth Factor; Intestinal Mucosa; Rats; Rats, Inbred F344; Stem Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A | 2008 |
[Protective effect of epigallocatechin-3-gallate on inflammatory bowel disease: experiment with rat models of induced colitis].
Topics: Animals; Blotting, Western; Catechin; Cyclooxygenase 2; Disease Models, Animal; Gene Expression; Inflammatory Bowel Diseases; Intestinal Mucosa; Random Allocation; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2007 |
Noninvasive ultrasound elasticity imaging (UEI) of Crohn's disease: animal model.
Topics: Animals; Colon; Crohn Disease; Disease Models, Animal; Elasticity; Elasticity Imaging Techniques; Female; Fibrosis; Image Interpretation, Computer-Assisted; In Vitro Techniques; Rats; Rats, Inbred Lew; Sensitivity and Specificity; Stress, Mechanical; Trinitrobenzenesulfonic Acid | 2008 |
VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Immunity, Cellular; Immunity, Innate; Lymph Nodes; Male; Mesentery; Mice; Mice, Inbred BALB C; Models, Immunological; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2008 |
Inflammation causes expression of NGF in epithelial cells of the rat colon.
Topics: Animals; Colitis; Disease Models, Animal; ELAV Proteins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Male; Mucous Membrane; Nerve Growth Factor; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Regulation of gut inflammation and th17 cell response by interleukin-21.
Topics: Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Humans; Interleukin-17; Interleukin-2 Receptor alpha Subunit; Interleukins; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; RNA; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2008 |
Corticotropin-releasing hormone deficiency is associated with reduced local inflammation in a mouse model of experimental colitis.
Topics: Animals; Anorexia; Colitis, Ulcerative; Corticotropin-Releasing Hormone; Disease Models, Animal; Female; Gene Expression; Inflammation; Interleukin-6; Leptin; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Mice, Knockout; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Weight Loss | 2008 |
Experimental colitis is associated with ultrastructural changes in inflamed and uninflamed regions of the gastrointestinal tract.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Endoplasmic Reticulum; Golgi Apparatus; Ileum; Inflammation; Male; Microscopy, Electron, Transmission; Mitochondria; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice.
Topics: Animals; Bystander Effect; CD28 Antigens; Cell Line; Cell Movement; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Histocompatibility Antigens; Immunity, Mucosal; Immunoglobulin Variable Region; Immunotherapy, Adoptive; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Oxazolone; Picrates; Receptors, Antigen, T-Cell; Receptors, IgG; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Induction of TNBS colitis in mice.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Leukocytes, Mononuclear; Lymph Nodes; Mice; Mucous Membrane; Trinitrobenzenesulfonic Acid | 2002 |
[Suppression of Schistosoma japonicum eggs on TNBS-induced colitis in mice].
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Ovum; Schistosoma japonicum; Trinitrobenzenesulfonic Acid | 2007 |
Protease-activated receptor-2 activation: a major actor in intestinal inflammation.
Topics: Animals; Cell Adhesion Molecules; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oxazolone; Peroxidase; Prostaglandin-Endoperoxide Synthases; Receptor, PAR-2; Trinitrobenzenesulfonic Acid | 2008 |
Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells.
Topics: Animals; Autoimmune Diseases; Bystander Effect; Cell Movement; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunity, Mucosal; Immunotherapy, Adoptive; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Transgenic; Oxazolone; Picrates; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Colitis; Crohn Disease; Disease Models, Animal; Endocannabinoids; Humans; Mice; Mice, Inbred C57BL; Polymorphism, Genetic; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis.
Topics: Acute Disease; Animal Feed; Animals; Colitis; Colon; Cyclooxygenase 2; Diet; Disease Models, Animal; Female; Organ Size; Peroxidase; Phytoestrogens; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Uterus | 2008 |
Non-lymphoid cells in experimental inflammatory bowel disease.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Dendritic Cells; Disease Models, Animal; Ethanol; Histocompatibility Antigens Class II; Inflammatory Bowel Diseases; Intestinal Mucosa; Macrophages; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats.
Topics: Animals; Blotting, Northern; Colitis; Colon; Disease Models, Animal; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 1995 |
The characterization of a rabbit model of inflammatory bowel disease.
Topics: Animals; Colitis, Ulcerative; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Inflammatory Bowel Diseases; Rabbits; Sodium Chloride; Time Factors; Trinitrobenzenesulfonic Acid | 1995 |
Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity.
Topics: Animals; Arginine; Calmodulin-Binding Proteins; Capsaicin; Colitis; Disease Models, Animal; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
A stable nitroxide radical effectively decreases mucosal damage in experimental colitis.
Topics: Acetates; Animals; Antioxidants; Colitis; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Intestinal Mucosa; Leukotriene B4; Leukotriene C4; Lipoxygenase; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Spin Labels; Time Factors; Trinitrobenzenesulfonic Acid | 1995 |
Antibodies to interleukin 12 abrogate established experimental colitis in mice.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; CD4 Lymphocyte Count; Colitis; Colon; Crohn Disease; Disease Models, Animal; Interferon-gamma; Interleukin-12; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Molecular Sequence Data; Spleen; Trinitrobenzenesulfonic Acid | 1995 |
Amelioration of chronic ileitis by nitric oxide synthase inhibition.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Chronic Disease; Disease Models, Animal; Guinea Pigs; Ileitis; Ileum; Intestinal Mucosa; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Peroxidase; Therapeutic Irrigation; Trinitrobenzenesulfonic Acid | 1993 |
Attenuation of epithelial injury in acute experimental colitis by immunomodulators.
Topics: Animals; Colitis; Colon; Cyclosporine; Disease Models, Animal; Epithelium; Immunosuppressive Agents; Male; Misoprostol; Neutrophils; Permeability; Peroxidase; Rabbits; Tacrolimus; Trinitrobenzenesulfonic Acid | 1993 |
Non-lymphoid cells in acute and chronic experimental inflammatory bowel disease.
Topics: Acute Disease; Administration, Rectal; Animals; Antibodies, Monoclonal; Chronic Disease; Colitis; Dendritic Cells; Disease Models, Animal; Histocompatibility Antigens Class II; Inflammatory Bowel Diseases; Lymphocyte Subsets; Lymphoid Tissue; Macrophage-1 Antigen; Macrophages; Neutrophils; Peyer's Patches; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 1994 |
Effect of leukotriene C4D4 antagonist on colonic damage induced by intracolonic administration of trinitrobenzene sulfonic acid in rats.
Topics: Animals; Chromones; Colon; Disease Models, Animal; Eicosanoids; Female; Inflammatory Bowel Diseases; Leukotriene C4; Leukotriene D4; Methacrylates; Peroxidase; Phenylpropionates; Rats; Rats, Sprague-Dawley; SRS-A; Thromboxane-A Synthase; Trinitrobenzenesulfonic Acid | 1995 |
Protective effect of epidermal growth factor in an experimental model of colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Epidermal Growth Factor; Ethanol; Gastric Mucosa; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1994 |
Mast cells are not essential to inflammation in murine model of colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Haptens; Male; Mast Cells; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 1994 |
Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Biliary Tract Diseases; Bilirubin; Colitis; Disease Models, Animal; Endotoxins; Interleukin-6; Liver Diseases; Male; Portal Vein; Rats; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid | 1994 |
Effect of epidermal growth factor on experimental colitis in the rat.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Eicosanoids; Epidermal Growth Factor; Ethanol; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Prednisolone; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1993 |
Nitric oxide release in response to gut injury.
Topics: Animals; Bile Acids and Salts; Capillary Permeability; Chromium Radioisotopes; Disease Models, Animal; Edetic Acid; Enterocolitis, Pseudomembranous; Epithelium; Female; Guinea Pigs; Ileitis; Inflammation; Intestinal Diseases; Nitric Oxide; Nitrites; Permeability; Peroxidase; Proteins; Rabbits; Swine; Therapeutic Irrigation; Trinitrobenzenesulfonic Acid | 1993 |
Defective modulation of colonic secretomotor neurons in a rabbit model of colitis.
Topics: Acetylcholine; Amiloride; Animals; Bucladesine; Colitis; Colon; Dinoprostone; Disease Models, Animal; Epithelium; Inflammation; Male; Membrane Potentials; Motor Neurons; Muscle, Smooth; Rabbits; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 1993 |
Inverse regulation of alpha- and beta-adrenoceptors during trinitrobenzenesulfonic acid (TNB)-induced inflammation in guinea-pig small intestine.
Topics: Animals; Dihydroalprenolol; Disease Models, Animal; Enteritis; Guinea Pigs; Intestinal Mucosa; Intestine, Small; Kinetics; Male; Membranes; Prazosin; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Trinitrobenzenesulfonic Acid; Tritium; Yohimbine | 1993 |
Guinea pig ileitis is attenuated by the leumedin N-(fluorenyl-9- methoxycarbonyl)-leucine (NPC 15199).
Topics: Animals; Disease Models, Animal; Fluorenes; Guinea Pigs; Ileitis; Intestines; Leucine; Peroxidase; Trinitrobenzenesulfonic Acid | 1993 |
Interleukin-2 activity of colonic lamina propria mononuclear cells in a rat model of experimental colitis.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Concanavalin A; Dinoprostone; Disease Models, Animal; Female; Inflammation; Interleukin-2; Intestinal Mucosa; Lymphocyte Activation; Lymphocytes; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values; Spleen; Trinitrobenzenesulfonic Acid | 1993 |
Thromboxanes, indomethacin, and experimental colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Indomethacin; Rats; Thromboxanes; Trinitrobenzenesulfonic Acid | 1993 |
Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid.
Topics: Animals; Benzenesulfonates; Colitis; Dinitrochlorobenzene; Disease Models, Animal; Haptens; Male; Neutrophils; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats.
Topics: Animals; Arginine; Body Weight; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusion Pumps, Implantable; Injections, Subcutaneous; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis.
Topics: Analysis of Variance; Animals; Chronic Disease; Colitis; Collagen; Collagenases; Colon; Colonic Diseases; Constriction, Pathologic; Dietary Fats, Unsaturated; Disease Models, Animal; Intestinal Obstruction; Male; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 1996 |
Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12.
Topics: Animals; Antibodies, Monoclonal; Bacteria; Colitis; Colon; Crohn Disease; Disease Models, Animal; Humans; Immune Tolerance; Immunologic Factors; Interleukin-10; Interleukin-12; Intestine, Small; Intestines; Leukocytes, Mononuclear; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Peyer's Patches; Rats; Recombinant Proteins; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Trinitrobenzenesulfonic Acid | 1996 |
Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.
Topics: Animals; Antibodies; CD40 Ligand; Colitis; Colon; Disease Models, Animal; Female; Interleukin-12; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Protein Binding; Th1 Cells; Trinitrobenzenesulfonic Acid | 1996 |
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Topics: Animals; Arginine; Colitis; Colon; Dexamethasone; Dilatation; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Hypoxanthines; Inflammation; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance.
Topics: Administration, Oral; Administration, Rectal; Animals; Antibody Formation; CD4-Positive T-Lymphocytes; Cytokines; Disease Models, Animal; Epitopes; Female; Haptens; Immune Tolerance; Immunosuppressive Agents; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 1996 |
Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice.
Topics: Adrenal Cortex Hormones; Adult; Aged; Animals; Base Sequence; Cells, Cultured; Crohn Disease; Cytokines; Disease Models, Animal; DNA; Enterocolitis; Female; Humans; Interleukin-10; Male; Mice; Middle Aged; Molecular Sequence Data; NF-kappa B; Oligonucleotides, Antisense; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 1996 |
[Immunohistochemistry of inducible nitric oxide synthase in rat with trinitrobenzene sulfonic acid induced colitis].
Topics: Animals; Colitis; Disease Models, Animal; Female; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
The effect of alpha-linolenic acid-rich emulsion on fatty acid metabolism and leukotriene generation of the colon in a rat model with inflammatory bowel disease.
Topics: alpha-Linolenic Acid; Animals; Body Weight; Cholesterol; Colon; Disease Models, Animal; Fatty Acids; Glucose; Inflammatory Bowel Diseases; Leukotriene B4; Male; Phospholipids; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Soybean Proteins; Trinitrobenzenesulfonic Acid | 1996 |
Bacterial peptides enhance inflammatory activity in a rat model of colitis.
Topics: Animals; Colitis; Dinoprostone; Disease Models, Animal; Eicosanoids; Intestinal Mucosa; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Peroxidase; Rats; Rats, Sprague-Dawley; Thromboxane B2; Trinitrobenzenesulfonic Acid | 1996 |
Impairment of antioxidants in colonic epithelial cells isolated from trinitrobenzene sulphonic acid-induced colitis rats. Protective effect of rebamipide.
Topics: Alanine; Analysis of Variance; Animals; Anti-Ulcer Agents; Antioxidants; Colitis; Culture Techniques; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Intestinal Mucosa; Male; Quinolones; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
Application of natural products in experimental models of intestinal inflammation in rats.
Topics: Acetic Acid; Alkaline Phosphatase; Animals; Biomarkers; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Leukotriene B4; Peroxidase; Quercetin; Rats; Rutin; Trinitrobenzenesulfonic Acid | 1996 |
Down-regulation of substance P receptors during colitis induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Colitis; Disease Models, Animal; Down-Regulation; Haptens; Humans; Indoles; Inflammatory Bowel Diseases; Isoindoles; Male; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Trinitrobenzenesulfonic Acid | 1996 |
Differences in immune responses to a low-molecular compound in three guinea-pig strains.
Topics: Animals; Antigen-Antibody Complex; Arthus Reaction; Disease Models, Animal; Female; Guinea Pigs; Hypersensitivity, Delayed; Immune System; Injections, Subcutaneous; Molecular Weight; Passive Cutaneous Anaphylaxis; Serum Albumin, Bovine; Species Specificity; Trinitrobenzenesulfonic Acid | 1997 |
Photopheresis, a possible therapy for airway hyperreactivity?
Topics: Animals; Bronchial Hyperreactivity; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Leukocyte Count; Macrophages; Male; Mice; Mice, Inbred BALB C; Photopheresis; Picryl Chloride; Trinitrobenzenesulfonic Acid | 1997 |
Effect of acute pentoxifylline treatment in an experimental model of colitis.
Topics: Animals; Colitis; Collagen; Colon; Disease Models, Animal; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1997 |
Role of cytokines in experimental colitis: relation to intestinal permeability.
Topics: Acute-Phase Proteins; Animals; Colitis; Colon; Coloring Agents; Cytokines; Disease Models, Animal; Evans Blue; Follow-Up Studies; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Macrophages; Male; Microscopy, Fluorescence; Permeability; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Trinitrobenzenesulfonic Acid | 1997 |
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.
Topics: Animals; Antibodies; Chronic Disease; Colitis; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Mice; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1997 |
A new experimental model for primary chronic pancreatitis.
Topics: Animals; Chronic Disease; Disease Models, Animal; Pancreatitis; Rats; Trinitrobenzenesulfonic Acid | 1997 |
Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis.
Topics: Analysis of Variance; Animals; Body Weight; Colitis; Colon; Diet; Disease Models, Animal; Drug Administration Schedule; Female; Glutamine; Interleukin-8; Intestinal Mucosa; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1997 |
Discrimination of site-specific alterations in gastrointestinal permeability in the rat.
Topics: Animals; Aspirin; Biological Transport; Cyclooxygenase Inhibitors; Digestive System; Disease Models, Animal; Gastrointestinal Diseases; Indomethacin; Rats; Trinitrobenzenesulfonic Acid | 1998 |
Intracolonic release of nitric oxide during trinitrobenzene sulfonic acid rat colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Leukotriene B4; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1997 |
Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells.
Topics: Animals; Biomarkers; Body Water; Chromium Radioisotopes; Chymases; Colitis; Colon; Dexamethasone; Disease Models, Animal; Edetic Acid; Granulocytes; Intestinal Absorption; Male; Mast Cells; Peroxidase; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Thioxanthenes; Trinitrobenzenesulfonic Acid; Xanthones | 1998 |
Oral administration of rutoside can ameliorate inflammatory bowel disease in rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Rats; Rats, Wistar; Rutin; Trinitrobenzenesulfonic Acid; Vasodilator Agents | 1998 |
Effect of methylprednisolone on the ulceration, matrix metalloproteinase distribution and eicosanoid production in a model of colitis in the rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dinoprostone; Disease Models, Animal; Eicosanoids; Leukocyte Count; Leukotriene B4; Metalloendopeptidases; Methylprednisolone; Neutrophils; Rabbits; Random Allocation; Trinitrobenzenesulfonic Acid | 1997 |
Viral vectors expressing immunoregulatory cytokines to treat inflammatory bowel disease.
Topics: Adenoviridae; Animals; Combined Modality Therapy; Crohn Disease; Disease Models, Animal; Genetic Therapy; Genetic Vectors; Humans; Interleukin-4; Rats; Trinitrobenzenesulfonic Acid | 1998 |
Cyclooxygenase-independent chemoprevention with an aspirin derivative in a rat model of colonic adenocarcinoma.
Topics: Adenocarcinoma; Animals; Aspirin; Azoxymethane; Colonic Neoplasms; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Isoenzymes; Male; Membrane Proteins; Mice; Pain Measurement; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1998 |
[Therapeutic effects of beclomethasone dipropionate enemas on colon damage of inflammatory bowel disease model rats].
Topics: Animals; Anti-Inflammatory Agents; Beclomethasone; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Enema; Inflammatory Bowel Diseases; Male; Organ Size; Rats; Rats, Inbred F344; Trinitrobenzenesulfonic Acid | 1998 |
Taurine can ameliorate inflammatory bowel disease in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colon; Disease Models, Animal; Eicosanoids; Inflammatory Bowel Diseases; Luminescent Measurements; Luminol; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Taurine; Trinitrobenzenesulfonic Acid | 1998 |
CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; CD4 Antigens; CD4-Positive T-Lymphocytes; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; DNA Primers; Female; Gene Expression; Humans; Immunization; Intestinal Mucosa; Leukocyte Common Antigens; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 1998 |
Effects of morin on an experimental model of acute colitis in rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flavonoids; Leukotriene B4; Malondialdehyde; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1998 |
[Effect of plaunotol on trinitrobenzene sulfonic acid and acetic acid induced colonic lesions in rats].
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Colon; Disease Models, Animal; Diterpenes; Dose-Response Relationship, Drug; Fatty Alcohols; Humans; Inflammatory Bowel Diseases; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1998 |
5-ASA-glutamate protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzensulfonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Eicosanoids; Glutamates; Leukotrienes; Prostaglandins; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1998 |
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Malondialdehyde; Mice; Neutrophils; Oxidative Stress; Permeability; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine; Up-Regulation | 1999 |
Hapten-induced colitis is associated with colonic patch hypertrophy and T helper cell 2-type responses.
Topics: Animals; Antibodies; Colitis, Ulcerative; Colon; Disease Models, Animal; Haptens; Hypertrophy; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-4; Interleukin-5; Mice; Mice, Inbred BALB C; Mice, Knockout; Peyer's Patches; T-Lymphocytes, Helper-Inducer; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 1999 |
Induction of iNOS in a rat model of acute colitis.
Topics: Acute Disease; Animals; Colitis; Disease Models, Animal; Enzyme Induction; Humans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Morphological and functional changes in the colonic epithelial cells in a rabbit model of colitis.
Topics: Animals; Binding Sites; Colitis; Colon; Dinoprostone; Disease Models, Animal; Epithelial Cells; Intestinal Mucosa; Ion Transport; Microscopy, Electron; Rabbits; Sodium Radioisotopes; Trinitrobenzenesulfonic Acid | 1999 |
Intestinal inflammation in adhesion molecule-deficient mice: an assessment of P-selectin alone and in combination with ICAM-1 or E-selectin.
Topics: Acetates; Animals; Colitis; Colon; Disease Models, Animal; E-Selectin; Gene Expression; Intercellular Adhesion Molecule-1; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Trinitrobenzenesulfonic Acid | 1999 |
Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.
Topics: Actins; Animals; Chronic Disease; Collagen; Desmin; Disease Models, Animal; Fibrosis; Glial Fibrillary Acidic Protein; Humans; Immunohistochemistry; Male; Pancreas; Pancreatitis, Alcoholic; Procollagen; Rats; Receptor, Platelet-Derived Growth Factor beta; RNA, Messenger; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 1999 |
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Male; Mesalamine; Models, Biological; Rats; Rats, Wistar; Reproducibility of Results; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1999 |
Experimental colitis induced by trinitrobenzenesulfonic acid: an ultrastructural and histochemical study.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Goblet Cells; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Medium-chain triglycerides modulate ileitis induced by trinitrobenzene sulfonic acid.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Ileitis; Immunoenzyme Techniques; Leukotriene B4; Male; Ornithine Decarboxylase; Prostaglandins E; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Triglycerides; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1999 |
Effects of spinal cholecystokinin receptor antagonists on morphine antinociception in a model of visceral pain in the rat.
Topics: Analgesics; Anesthesia; Animals; Benzodiazepinones; Colitis; Colon; Devazepide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Rectum; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Viscera | 2000 |
Therapeutic effects of the endothelin receptor antagonist Ro 48-5695 in the TNBS/DNBS rat model of colitis.
Topics: Animals; Benzenesulfonates; Colitis, Ulcerative; Disease Models, Animal; Endothelin Receptor Antagonists; Endothelin-1; Inflammatory Bowel Diseases; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Sulfonamides; Trinitrobenzenesulfonic Acid | 2000 |
Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats.
Topics: Animals; Bile; Colitis; Cytochrome P-450 Enzyme System; Disease Models, Animal; Liver; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-rel; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2000 |
Anti-IL12 imposes the death sentence on Th1 cells in TNBS colitis--is there a light at the end of the tunnel for Crohn's disease?
Topics: Animals; Antibodies; Apoptosis; Crohn Disease; Disease Models, Animal; Humans; Inflammation; Interleukin-12; Mice; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2000 |
Oral administration of inducible nitric oxide synthase inhibitors reduces nitric oxide synthesis but has no effect on the severity of experimental colitis.
Topics: Administration, Oral; Animals; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Reference Values; Severity of Illness Index; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid | 2000 |
Evaluation of oxidative stress in experimental colitis: effects of L-arginine-nitric oxide pathway manipulation.
Topics: Analysis of Variance; Animals; Arginine; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid | 2000 |
Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Crohn Disease; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-16; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2000 |
Treatment with fluoride or bisphosphonates prevents bone loss associated with colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Diphosphonates; Disease Models, Animal; Inflammatory Bowel Diseases; Intestine, Large; Male; Osteoporosis; Pamidronate; Rats; Rats, Wistar; Sodium Fluoride; Tibia; Trinitrobenzenesulfonic Acid | 2000 |
Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation.
Topics: Animals; Bacteria; Base Sequence; Colitis; Disease Models, Animal; DNA Primers; Humans; Immunoglobulin E; Interleukin-4; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Permeability; Receptors, IgE; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2001 |
CD40/CD40 ligand interactions are critical for elicitation of autoimmune-mediated fibrosis in the lung.
Topics: Animals; Antibodies, Blocking; Autoimmune Diseases; Bronchoalveolar Lavage Fluid; CD40 Antigens; CD40 Ligand; Cell Movement; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Haptens; Hydroxyproline; Injections, Intraperitoneal; Interleukin-12; Intubation, Intratracheal; Mice; Mice, Inbred BALB C; Mice, Knockout; Monocytes; Pulmonary Fibrosis; Trinitrobenzenesulfonic Acid; Up-Regulation | 2001 |
Differential role of selectins in experimental colitis.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Colitis; Disease Models, Animal; E-Selectin; Endothelium, Vascular; L-Selectin; Leukocytes; Male; P-Selectin; Rats; Rats, Sprague-Dawley; Selectins; Trinitrobenzenesulfonic Acid; Venules | 2001 |
Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Guanidines; In Vitro Techniques; Inflammation; Inflammatory Bowel Diseases; Male; Muscle Contraction; Muscle, Smooth; NADPH Dehydrogenase; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Trinitrobenzenesulfonic Acid | 2001 |
Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat.
Topics: Animals; Cell Adhesion Molecules; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Disease Progression; E-Selectin; Gene Expression Regulation; Granulocytes; Haptens; Inflammatory Bowel Diseases; Integrin beta Chains; Integrins; Intercellular Adhesion Molecule-1; Interferon-gamma; Intestinal Mucosa; Monocytes; P-Selectin; Rats; Rats, Sprague-Dawley; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1 | 2001 |
Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine | 2001 |
Amelioration of immune-mediated experimental colitis: tolerance induction in the presence of preexisting immunity and surrogate antigen bystander effect.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Immune Tolerance; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Proteins; Severity of Illness Index; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2001 |
An oral drug delivery system targeting immune-regulating cells ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis.
Topics: Administration, Oral; Animals; Cell Division; Colitis; Cyclooxygenase 1; Cytokines; Dexamethasone; Disease Models, Animal; Drug Delivery Systems; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Microspheres; NF-kappa B; Nitric Oxide; Peroxidase; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2001 |
Beneficial effects of Batimastat (BB-94), a matrix metalloproteinase inhibitor, in rat experimental colitis.
Topics: Animals; Chronic Disease; Colitis, Ulcerative; Disease Models, Animal; Hematoxylin; Intestinal Mucosa; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peroxidase; Phenylalanine; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thiophenes; Trinitrobenzenesulfonic Acid | 2001 |
N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats.
Topics: Amidines; Animals; Benzylamines; Blotting, Western; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Female; Injections, Intraperitoneal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Oral administration of unmodified colonic but not small intestinal antigens protects rats from hapten-induced colitis.
Topics: Administration, Oral; Animals; Antigens; Colitis, Ulcerative; Colon; Disease Models, Animal; Female; Haptens; Immunization, Passive; Intestine, Small; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2001 |
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
Topics: Animals; Antibodies; Colitis; Crohn Disease; Disease Models, Animal; Humans; Inflammation; Interleukin-18; Intestinal Mucosa; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2001 |
Delayed puberty and response to testosterone in a rat model of colitis.
Topics: Animals; Body Constitution; Body Weight; Colitis; Disease Models, Animal; Eating; Female; Follicle Stimulating Hormone; Genitalia, Male; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Nutrition Disorders; Organ Size; Pituitary-Adrenal System; Prolactin; Rats; Rats, Wistar; Sexual Maturation; Testosterone; Trinitrobenzenesulfonic Acid | 2001 |
Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis.
Topics: Animals; Body Weight; Colitis; Colon; Disease Models, Animal; Enteral Nutrition; Enteritis; Feces; Gastrostomy; Intestines; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2001 |
Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Chronic Disease; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2001 |
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Down-Regulation; Enzyme Activation; Hyaluronan Receptors; Interferon-gamma; Interleukin-12; Interleukin-2; Mice; Mice, Inbred BALB C; Oligopeptides; Peptide Fragments; Receptor, PAR-2; Receptors, Thrombin; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2001 |
Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Chronic Disease; Colitis; Disease Models, Animal; Female; Flavonoids; Interleukin-1; Intestinal Mucosa; Leukotriene B4; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Contrasting roles of IL-12p40 and IL-12p35 in the development of hapten-induced colitis.
Topics: Animals; Basement Membrane; CD8-Positive T-Lymphocytes; Cells, Cultured; Colon; Crohn Disease; Disease Models, Animal; Female; Haptens; Interferon-gamma; Interleukin-12; Interleukin-18; Male; Mice; Mice, Inbred BALB C; Mice, Knockout; Receptors, Interleukin; Receptors, Interleukin-12; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2002 |
Anorexia in a rat model of colitis: interaction of interleukin-1 and hypothalamic serotonin.
Topics: Animals; Anorexia; Antibodies; Body Weight; Colitis; Disease Models, Animal; Eating; Injections, Intraventricular; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Neuroimmunomodulation; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Serotonin; Sialoglycoproteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2002 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2001 |
Polynitroxylated starch/TPL attenuates cachexia and increased epithelial permeability associated with TNBS colitis.
Topics: Adult; Animals; Antioxidants; Body Weight; Cachexia; Cell Adhesion; Colitis; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Female; Free Radicals; Humans; Hydroxyethyl Starch Derivatives; Intestinal Mucosa; Mice; Mice, Inbred Strains; Neutrophils; Nitrogen Oxides; Permeability; Spin Labels; Survival Rate; Trinitrobenzenesulfonic Acid; Umbilical Veins | 2002 |
Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Muscle Contraction; Nerve Block; Neural Inhibition; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rabbits; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Trinitrobenzenesulfonic Acid | 2002 |
Porcine ileitis model induced by TNBS-ethanol instillation.
Topics: Animals; Disease Models, Animal; Drug Combinations; Ethanol; Female; Ileitis; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Swine; Time Factors; Trinitrobenzenesulfonic Acid | 2002 |
Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat.
Topics: Alkaline Phosphatase; Animals; Antidiarrheals; Biological Transport; Carbachol; Colitis, Ulcerative; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Malondialdehyde; Neutrophils; Nitric Oxide Synthase; Organ Culture Techniques; Peroxidase; Quercetin; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Water | 2002 |
Experimental colitis attenuates development of toxin-induced cholangitis in rats.
Topics: Animals; Bile Acids and Salts; Bilirubin; Cholangitis; Colitis, Ulcerative; Disease Models, Animal; Interleukin-10; Male; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; Up-Regulation | 2002 |
A comparative analysis of two models of colitis in rats.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Ethanol; Intestinal Mucosa; Male; Peroxidase; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
Chronic intrajejunal TNBS application in TNBS-sensitized rats: a new model of chronic inflammatory bowel diseases.
Topics: Aminosalicylic Acids; Animals; Disease Models, Animal; Female; Immunization; Inflammatory Bowel Diseases; Intestinal Mucosa; Jejunum; Mesalamine; Rats; Rats, Sprague-Dawley; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1992 |
Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Colitis; Colon; Cyclosporine; Disease Models, Animal; Indomethacin; Male; Prostaglandins; Rats; Rats, Wistar; Thromboxane B2; Trinitrobenzenesulfonic Acid | 1992 |
Ketotifen effectively prevents mucosal damage in experimental colitis.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Ketotifen; Male; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
[Experimental ileitis in dogs induced by trinitrobenzenesulfonic acid].
Topics: Animals; Disease Models, Animal; Dogs; Ileal Diseases; Ileitis; Male; Trinitrobenzenesulfonic Acid; Ulcer | 1992 |
Protective influence of oxypurinol on the trinitrobenzene sulfonic acid(TNB) model of inflammatory bowel disease in rats.
Topics: Animals; Colon; Disease Models, Animal; Free Radical Scavengers; Free Radicals; Inflammatory Bowel Diseases; Kinetics; Nucleotides; Oxypurinol; Rats; Thiobarbiturates; Trinitrobenzenesulfonic Acid; Xanthine Oxidase | 1992 |
An orally active inhibitor of leukotriene synthesis accelerates healing in a rat model of colitis.
Topics: Administration, Oral; Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Indoles; Inflammation; Leukotriene B4; Male; Rats; Rats, Inbred Strains; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1990 |
Hapten-induced model of chronic inflammation and ulceration in the rat colon.
Topics: Animals; Colitis, Ulcerative; Colon; Disease Models, Animal; Ethanol; Female; Intestinal Mucosa; Nitrobenzenes; Rats; Rats, Inbred Strains; Time Factors; Trinitrobenzenesulfonic Acid | 1989 |
Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis.
Topics: Animals; Colitis; Disease Models, Animal; Diterpenes; Ginkgolides; Lactones; Male; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1988 |
[Model of a stable form of delayed hypersensitivity to chemical allergens].
Topics: Allergens; Animals; Disease Models, Animal; Female; Freund's Adjuvant; Hypersensitivity, Delayed; Immunization; Mice; Mice, Inbred BALB C; Skin Tests; Time Factors; Trinitrobenzenesulfonic Acid | 1987 |
Immunohistochemical evidence for degeneration of cholinergic neurons in the forebrain of the rat following injection of AF64A-picrylsulfonate into the dorsal hippocampus.
Topics: Alzheimer Disease; Animals; Aziridines; Azirines; Choline; Choline O-Acetyltransferase; Cholinergic Fibers; Diencephalon; Disease Models, Animal; Hippocampus; Rats; Rats, Inbred Strains; Serotonin; Telencephalon; Trinitrobenzenesulfonic Acid | 1986 |