trinitrobenzenesulfonic acid has been researched along with Colitis in 1482 studies
*Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (0.27) | 18.7374 |
| 1990's | 152 (10.26) | 18.2507 |
| 2000's | 522 (35.22) | 29.6817 |
| 2010's | 683 (46.09) | 24.3611 |
| 2020's | 121 (8.16) | 2.80 |
| Authors | Studies |
|---|---|
| Abdel-Aziz, H; Efferth, T; Khayyal, MT; Scherner, O; Wadie, W | 1 |
| Fichna, J; Jacenik, D; Krajewska, WM; Małecka-Panas, E; Mokrowiecka, A; Salaga, M; Zatorski, H; Zielińska, M | 1 |
| Chen, M; Chen, Z; Li, X; Mao, R; Miao, X; Qiu, C; Ren, J; Wang, P; Yin, T; You, Y; Zheng, R; Zhou, H | 1 |
| Gallyas, F; Kálmán, N; Kovács, D; Radnai, B; Schicho, R; Vámos, E; Vántus, VB | 1 |
| Ha, NC; Hong, S; Ju, S; Jung, Y; Yoo, JW | 1 |
| Aziz, M; Bôle-Feysot, C; Dupont-Lucas, C; Goichon, A; Guerin, C; Marion-Letellier, R; Nicol, L; Pala, M; Salameh, E; Savoye, G; Savoye-Collet, C | 1 |
| Chávez, MN; Das, S; Diaz, OE; Frede, A; Krais, AM; Luo, X; Morales, RA; Sorini, C; Villablanca, EJ; Wincent, E | 1 |
| Dai, F; Dong, G; He, H; Ma, C; Wang, Y; Xiong, H; Yang, Y; Yu, W; Zhang, H; Zhou, G; Zhu, F | 1 |
| Ben-Khemis, M; Boudiaf, K; Chevreux, G; Dang, PM; El-Benna, J; Leger, T; Liu, D; Marie, JC; Pelletier, AL; Pintard, C; Song, Z; Terrier, S | 1 |
| Chen, L; Fang, L; Gao, X; Jia, J; Li, G; Lin, R; Liu, Z; Sun, M; Wu, W; Wu, X | 1 |
| Alotaibi, NM; Murad, HA; Shaikh-Omar, A | 1 |
| Bettadaiah, BK; Mathew, NS; Muthukumar, SP; Negi, PS | 1 |
| Chen, J; Liu, C; Liu, YJ; Lv, X; Qi, L; Wang, X; Wu, J; Zhu, S | 1 |
| Geesala, R; Lin, YM; Qiu, S; Shi, XZ; Zhang, K | 1 |
| Chen, T; Kuang, X; Li, Z; Shen, T; Wu, J | 1 |
| Liu, YH; Qu, HH; Zhang, ML | 1 |
| Han, R; Qin, H; Wang, L; Yuan, P; Zang, K | 1 |
| Mateus, V; Pinto, R; Silva, I; Solas, J | 1 |
| Ibrahim, HIM; Khalifa, A; Sheikh, A | 1 |
| Deng, C; Hu, J; Hu, T; Long, Y; Ma, X; Shen, Y; Wu, W; Zeng, Y; Zhao, Y | 1 |
| Chen, SY; Hong, CJ; Hsu, YH; Yen, GC | 1 |
| Ahmed, O; Alqurashi, T; Hussien, M; Murad, H | 1 |
| Chen, L; Chen, LL; Chen, YP; Chu, KD; Fan, LM; Liu, YJ; Wang, Y; Xu, W; Xu, WH; Zhang, JP; Zhang, YQ | 1 |
| Abdollahi, A; Chaboki, A; Dehpour, AR; Hamaneh, AM; Mohammadi, S; Rashidian, A; Shayan, M; Sheibani, M; Yousefi-Manesh, H | 1 |
| Boirivant, M; Butera, A; Campanile, D; Crippa, L; Di Carlo, N; Labbaye, C; Quaranta, MT; Saulle, E; Spinello, I | 1 |
| Joo, MK; Kim, DH; Ma, XY; Son, YH; Yoo, JW | 1 |
| Liu, H; Sun, MZ; Xiao, H; Zhang, C; Zhang, HC; Zhang, JN; Zhao, HR; Zhao, Y | 1 |
| Guerra, S; Mateus, V; Mendes, P; Pinto, R; Silva, I | 1 |
| Horsnell, W; Katsandegwaza, B; Smith, K | 1 |
| Chen, QQ; Deng, F; Li, DW; Li, J; Li, Y; Ling Hu, EQ; Wan, J; Zhu, WY | 1 |
| Hou, J; Li, H; Liu, X; Mu, D; Ni, Z; Tang, S; Zheng, S | 1 |
| Chen, W; Chen, X; He, F; He, Y; Li, L; Lin, H; Liu, Q; Lu, J; Ni, B; Xu, R; Yang, F; Zhang, Q; Zheng, X; Zhong, X; Zou, X | 1 |
| Chu, S; Cui, D; Gao, F; Liu, Y; Shou, Z; Wei, C; Yang, J; Yu, T; Zhu, F; Zuo, D | 1 |
| Blanc, P; Boutillier, D; Chamaillard, M; Couturier-Maillard, A; Grangette, C; Hrdý, J; Lapadatescu, C; Pot, B; Procházka, J; Ryffel, B | 1 |
| Abdollahi, M; Baeeri, M; Ghafour-Broujerdi, E; Gholami, M; Hassani, S; Mousavi, T; Rahimifard, M; Vakhshiteh, F | 1 |
| Cui, Y; Hu, D; Huang, T; Kabayama, S; Ochi, Y; Shigeta, M; Watanabe, Y | 1 |
| Estarreja, J; Mateus, V; Pinto, R; Silva, I | 1 |
| Astarcı, HM; Buğdaycı, G; Cinpolat, HY; Şengül, N | 1 |
| Hayashi, T; Horie, S; Kato, S; Kido, MA; Matsumoto, K; Mizuno, T; Nishioka, T; Okamura, R; Sugimoto, F; Yasuda, H | 1 |
| Cao, YN; Liu, KC; Sun, M; Tu, PF; Wang, XX; Zhang, XM; Zhang, Y; Zou, HY | 1 |
| Wu, S; Xie, Y; Xiong, H; Xue, G; Zhang, Y; Zhao, Q; Zhao, R; Zhou, N | 1 |
| Chudan, S; Furusawa, Y; Ikushiro, S; Ishibashi, R; Nagai, Y; Nishikawa, M; Tabuchi, Y | 1 |
| Bai, W; Cao, Y; Chen, Z; Hao, J; He, J; Heng, Z; Luo, X; Lv, L; Meng, C; Wang, L; Wang, X | 1 |
| Bartolí, R; Bernal, C; Domènech, E; Garcia, A; Garcia-Jaraquemada, A; Jou-Ollé, E; Llaves, M; Lorén, V; Mañosa, M; Manyé, J; Pertegaz, A; Schiering, K; Suau, R; Vergara, P | 1 |
| Deng, L; Li, C; Liu, M; Lu, Q; Luo, D; Ma, R | 1 |
| Im, M; Jang, SE; Jin, H; Kim, HS; Kim, JW; Kim, KJ; Kyung, S | 1 |
| Fan, X; Huang, W; Huang, Y; Qin, R; Su, Y; Wang, H; Wang, L; Yao, Y; Zhang, Z | 1 |
| Chen, Y; Fan, T; Li, J; Tian, Z; Wang, X; Wu, J; Zhuang, X | 1 |
| Fu, Y; Gu, M; He, Y; Li, R; Lin, S; Pan, Y; Sheng, J; Tao, Y; Wang, J; Wang, Z; Wei, P; Wu, Z; Xie, H; Xu, J; Zhang, C | 1 |
| Edelblum, KL; Kuo, WT; Nilsen, SP; Ong, MLDM; Shashikanth, N; Shen, L; Turner, JR; Wang, Y; Wu, L; Zha, J; Zuo, L | 1 |
| Du, J; Li, X; Li, YC; Sun, Y; Wei, X; Xun, Z | 1 |
| Chen, C; Czapor-Irzabek, H; Fichna, J; Gorniak, A; Karolewicz, B; Krajewska, JB; Owczarek, A; Pietruszka, P; Tomczyk, D | 1 |
| Calabresi, MFF; Di Stasi, LC; Mello, FPF; Miranda, JRA; Próspero, AG; Soares, G; Tanimoto, A | 1 |
| Benarafa, C; Burgener, SS; Candalh, C; Chatfield, S; Dang, PM; De Chiara, A; Desplancq, D; El-Benna, J; Favier, M; Frachet, P; Housset, D; Hurtado-Nedelec, M; Lagoutte, I; Marie, JC; Marzaioli, V; Mocek, J; Ohayon, D; Pintard, C; Renault, G; Tacnet-Delorme, P; Thieblemont, N; Walker, F; Weiss, E; Witko-Sarsat, V | 1 |
| Alvarenga, V; Baetas da Cruz, W; Bernardazzi, C; Bonfá, ND; Castelo-Branco, MT; de Souza, HSP; Madi, K; Nanini, H; Pêgo, B; Schanaider, A; Silva, PTD | 1 |
| Alam, MM; Huang, Y; Mathur, R; Zhao, XF; Zhu, X | 1 |
| Chun, J; Hwang, SW; Im, JP; Kim, JH; Kim, JS; Koh, J; Lee, C | 1 |
| Dziendzikowska, K; Gajewska, M; Gromadzka-Ostrowska, J; Harasym, J; Wilczak, J; Żyła, E | 1 |
| Aguiar, P; Antúnez-López, JR; Blanco-Méndez, J; Fernández-Ferreiro, A; Gómez-Lado, N; Lamela-Gómez, I; Lázare-Iglesias, H; Luzardo-Álvarez, A; Otero-Espinar, FJ; Pombo-Pasín, M; Rey-Bretal, D; Ruibal, Á; Seoane-Viaño, I | 1 |
| Jang, SE; Min, SW | 2 |
| Khan, I; Khan, K | 1 |
| Chun, H; Jones-Hall, YL; Kozik, AJ; Nakatsu, CH | 2 |
| Alrafas, HR; Busbee, PB; Nagarkatti, M; Nagarkatti, PS | 1 |
| Batista, ÂG; Bogusz Junior, S; Cazarin, CBB; da Cruz-Höfling, MA; da Silva-Maia, JK; Leal, RF; Maróstica Junior, MR; Soares, ES | 1 |
| Chen, Y; Gao, C; Guo, Z; Wang, J; Xiao, J; Zhou, Z | 1 |
| Al Nabhani, Z; Barreau, F; Berrebi, D; Cerf-Bensussan, N; Daniel, F; Dussaillant, M; Hugot, JP; Madre, C; Martinez-Vinson, C; Montcuquet, N; Ogier-Denis, E; Roy, M; Zouali, H | 1 |
| Dai, Z; Li, Y; Lin, X; Meng, S; Wang, H; Wei, D; Yang, J; Yang, R | 1 |
| He, XW; Hu, T; Lan, P; Liang, ZX; Liu, GH; Liu, HS; Liu, XH; Smith, LC; Wu, XJ; Wu, XR; Zhang, Y; Zheng, XB; Zhou, C | 1 |
| Chen, QQ; Chen, Z; Du, HT; Li, Y; Wan, J; Yuan, J | 1 |
| Fan, H; Liao, Y; Liu, X; Nan, Z; Tan, C; Tan, S; Tang, Q; Zhang, M; Zuo, D | 1 |
| Banerjee, S; Djerdjouri, B; Mouzaoui, S | 1 |
| Barbosa, ALDR; Carneiro, TB; da Cruz Júnior, JS; da Silva Costa, DV; da Silva Monteiro, CE; de Brito, TV; de Oliveira, JS; de Souza, MHLP; Franco, AX; Gomes Duarte, AS; Júnior, GJD; Silva, RO; Soares, PMG; Vasconcelos, DFP | 1 |
| Allahverdi, A; Asadi, F; Ebrahimi-Barough, S; Heidari Barchi Nezhad, R; Khajouee Ravari, S; Lotfibakhshaiesh, N; Mirzaei, MR; Mirzahosseini-Pourranjbar, A; Niknia, S; Tashakori, M; Yousefi-Ahmadipour, A | 1 |
| Chen, JD; Gharibani, P; Tu, L; Yin, J; Zhang, N | 1 |
| Albuquerque, RM; Araújo E Silva, AC; Dittz, D; Ferreira, Ê; Freitas, KM; Lopes, MTP; Pizzitola, MP; Salas, CE | 1 |
| Lu, Y; Sun, Y; Wu, L; Xu, J; Yu, P | 1 |
| Cagnon, VHA; Cazarin, CBB; Emanuelli, T; Lamas, CA; Maróstica Júnior, MR; Maurer, LH; Minuzzi, NM; Morari, J; Nichelle, SM; Quatrin, A; Velloso, LA | 1 |
| Alard, J; Blanc, P; Boulard, O; Boutillier, D; Cesaro, A; Chamaillard, M; Couturier-Maillard, A; Delacre, M; Grangette, C; Hrdý, J; Lapadatescu, C; Pot, B; Ryffel, B | 1 |
| Cui, J; Gao, J; Guo, W; Jiang, C; Jiao, C; Li, Y; Liu, W; Xu, Q; Zhong, H | 1 |
| Chen, Q; Chen, Y; Guo, Z; He, Q; Xiu, W | 1 |
| Al Ojaimi, Y; Bahr, GM; Bazzi, S; Echtay, KS; Khachab, M | 1 |
| Cai, XS; Chen, ZL; He, JH; Lei, L; Li, X; Wu, JH; Yuan, YJ | 1 |
| Dong, W; Huang, F; Mei, Y; Wang, J; Wu, J; Zhang, T | 1 |
| Indah Widasari, D; Putri Umizah, L; Setyo, P; Wasityastuti, W | 1 |
| da Cunha, VP; Machado, DCC; Miyoshi, A; Pereira, VB; Preisser, TM; Santana, MP | 2 |
| Almási, N; Baráth, Z; Csonka, Á; Dvorácskó, S; Kupai, K; Murlasits, Z; Pósa, A; Tömböly, C; Török, S; Valkusz, Z; Varga, C | 1 |
| Huang, G; Li, S; Tang, X; Zhang, T | 1 |
| Chen, JDZ; Gharibani, P; Tu, L; Yin, J | 1 |
| Bender, O; Durmus, A; Durmus, I; Karatepe, O | 1 |
| Bai, X; Jin, X; Liu, M; Qu, Z; Wang, X; Wang, Y; Xu, N; Yang, Y | 1 |
| Bai, X; Ding, J; Guo, H; Jin, X; Liu, M; Liu, X; Pang, J; Yang, Y; Zhang, L; Zhang, Y | 1 |
| Abiodun, OO; Nwadike, N; Oshinloye, AO; Sosanya, AS | 1 |
| Bálint, B; Balogh, P; Boros, É; Kellermayer, Z; Maróti, Z; Nagy, I; Prontvai, B; Sarlós, P; Varga, C; Vincze, Á | 1 |
| Biagioli, M; Bordoni, M; Carino, A; Di Giorgio, C; Distrutti, E; Fiorucci, S; Marchianò, S; Roselli, R | 1 |
| Dong, Y; Gao, T; Huo, C; Song, C; Sun, Y; Wang, P; Xing, J; Yan, Y; Zhang, R | 1 |
| Jin, S; Li, D; Luan, X; Tian, F; Xie, Y; Yan, B | 1 |
| Chen, D; Gao, JG; Gu, XW; Jin, X; Li, YM; Ren, Y; Yan, TL; Yu, MS; Zhang, MM; Zhou, XX | 1 |
| Hubens, G; Pype, C; Timmermans, JP; Uyttebroek, L; Van Nassauw, L | 1 |
| Sharma, S; Sinha, VR | 1 |
| Cao, X; Chen, S; Duan, L; Guo, Z; Han, Z; Han, ZC; Huang, H; Li, Z; Wang, C; Zhao, X; Zhou, M | 1 |
| Altinel, Y; Çelik, A; Ercan, G; Erçetin, C; Gülçiçek, OB; Özkaya, G; Uzun, H; Yalçın, Ş; Yavuz, E | 1 |
| Assohoun, ALW; Boudebbouze, S; Boutillier, D; Cuffaro, B; Desramaut, J; Grangette, C; Hrdý, J; Maguin, E; Salomé-Desnoulez, S; Súkeníková, L; Waligora-Dupriet, AJ | 1 |
| Brzozowski, T; Dieterich, W; Konturek, K; Konturek, PC; Krzysiek-Maczka, G; Kwiecien, S; Magierowska, K; Magierowski, M; Neurath, M; Ptak-Belowska, A; Sliwowski, Z; Strzalka, M; Szczyrk, U; Targosz, A; Wirtz, S; Wojcik, D; Zopf, Y | 1 |
| Liang, Y; Luo, S; Nong, F; Wen, B; Xing, S; Zhao, Z; Zhou, L | 1 |
| Lv, B; Meng, L; Shen, M; Wang, M; Zhang, B | 1 |
| Chen, B; Chen, M; Chen, P; Feng, R; He, Y; Li, X; Li, Y; Mao, R; Qiu, Y; Tian, Z; Wang, Y; Zeng, Z; Zhang, S; Zhang, Y; Zhu, L | 1 |
| Bauer, M; Chmielowiec-Korzeniowska, A; Fabisiak, A; Fabisiak, N; Fichna, J; Kamysz, E; Kamysz, W; Kordek, R; Tymczyna, L | 1 |
| Bednarz-Misa, I; Duda-Madej, A; Dzimira, S; Krzystek-Korpacka, M; Kucharska, AZ; Matuszewska, A; Merwid-Ląd, A; Nowak, B; Piórecki, N; Rutkowska, M; Sobieszczańska, B; Sozański, T; Szandruk-Bender, M; Szeląg, A; Turniak, M; Walczuk, U; Wiatrak, B | 1 |
| Amamou, A; Aziz, M; Bôle-Feysot, C; Colasse, E; David, A; Dupont-Lucas, C; Guerin, C; Jarbeau, M; Marion-Letellier, R; Nicol, L; Pala, M; Savoye, G; Savoye-Collet, C | 1 |
| Higashimura, Y; Ishikawa, T; Itoh, Y; Kamada, K; Katada, K; Mizushima, K; Naito, Y; Okayama, T; Takagi, T; Uchiyama, K | 1 |
| Duan, S; Gao, Y; Li, T; Li, Y; Lyu, L; Wang, Y; Xu, L | 1 |
| Bruce, J; Goggins, BJ; Horvat, JC; Keely, S; Knight, D; Liu, G; Mathe, A; Minahan, K; Pryor, J; Sherwin, S; Soh, WS; Walker, MM | 1 |
| Du, YL; He, J; Huang, HL; Li, YF; Nie, YQ; Xu, HM; Xu, J; Zhao, C; Zhou, YJ; Zhou, YL | 1 |
| Brumovsky, PR; Chi, L; Emadi, S; Feng, B; Guo, T; Han, M; Patel, S; Pierce, DM; Shah, D | 1 |
| Capas-Peneda, S; Dias-Pereira, P; Duarte-Araújo, M; Esteves-Monteiro, M; Ferreira-Duarte, M; Gonçalves-Monteiro, S; Magro, F; Menezes-Pinto, D; Morato, M; Rodrigues-Pinto, T | 1 |
| Chattopadhyay, N; Mehta, P; Mittal, M; Rajender, S; Rajput, S | 1 |
| Fukushi, S; Kawabata, A; Matsui, K; Okazaki, K; Sekiguchi, F; Tsubota, M | 1 |
| Arunachalam, K; Damazo, AS; Duckworth, CA; Figueiredo, FF; Leonti, M; Macho, A; Martins, DTO; Matchado, MS; Oliveira, DM; Pavan, E; Thangaraj, P | 1 |
| Arab, HH; Eid, AH; Mahmoud, AM; Senousy, MA | 1 |
| Ala, M; Dehpour, AR; Hashemian, SM; Mohammad Jafari, R; Rashidian, A; Shayesteh, S; Sorouri, M; Yousefi-Manesh, H | 1 |
| Awasthi, BP; Chaudhary, P; Jeong, BS; Karmacharya, U; Kim, JA; Kim, YE; Lee, IH; Nam, TG; Regmi, SC | 1 |
| Jiang, Y; Jin, Q; Kuang, Y; Liu, K; Long, D; Qian, K; Wang, S; Yao, H; Yuan, L; Zhao, H | 1 |
| Chen, J; Fu, Y; Huang, Z; Ma, G; Shi, T; Wang, W; Zhang, J; Zhang, Y; Zhu, J | 1 |
| Chandra, J; Dejanovic, D; Li, J; McDonald, C; Rieder, F; Zangara, MT | 1 |
| Huo, LL; Sun, ZR | 1 |
| Clark, RJ; Cristofori-Armstrong, B; Haigh, OL; Loukas, A; Lutzky, VP; Miles, JJ; Mulvenna, JP; Navarro, S; Rosengren, KJ; Ryan, RYM; Smallwood, TB; Tungatt, K; Watkins, TS | 1 |
| Chen, B; Chen, J; Huang, C; Tan, G; Zhi, F | 1 |
| Huang, M; Jiang, W; Luo, C; Ren, Y; Zhang, X | 1 |
| Ling-Fen, X; Tian-Chu, H; Yin, B | 1 |
| Chen, L; Chen, RY; Fan, JH; Gu, GL; Jiang, HX; Jin, H; Li, SQ; Liang, ZL; Liu, GF; Lu, F; Lv, XD; Lv, XP; Qin, LF; Wang, HQ; Xie, YF; Zhan, LL | 1 |
| Amamou, A; Aziz, M; Goichon, A; Guérin, C; Marion-Letellier, R; Rouland, M; Savoye, G; Yaker, L | 1 |
| Bartoszek, A; Binienda, A; Dziedziczak, K; Fabisiak, A; Fichna, J; Kordek, R; Krajewska, JB; Mosińska, P; Niewinna, K; Salaga, M; Talar, M; Tarasiuk, A | 1 |
| Almeida, LM; Dinis, TC; Figueiredo, I; Freitas, V; Pereira, R; Pereira, SR | 1 |
| Chen, J; Fu, Y; Gu, WJ; Huang, Z; Li, J; Ma, J; Shi, X; Song, XY; Xiao, S; Yang, Y; Zhang, J | 1 |
| Chen, J; Duan, L; Shi, G; Tao, Y; Tu, L; Xie, Z; Xu, D; Yu, B | 1 |
| Conner, EM; Reglinski, J; Smith, WE; Zeitlin, IJ | 1 |
| Kaneko, Y; Kato, K; Kojo, Y; Onoue, S; Sato, H; Seto, Y; Suzuki, H; Tsukada, R | 1 |
| Boros, M; Érces, D; Ghyczy, M; Hartmann, P; Jász, DK; Lajkó, N; Molnár, R; Szűcs, S; Tóth, G; Ugocsai, M; Varga, G | 1 |
| Hahm, KB; Kang, JX; Surh, YJ; Yum, HW | 1 |
| Blennerhassett, MG; Ghasemlou, N; Lourenssen, SR; Parlow, LRG; Winterborn, AN | 1 |
| Ni, R; Qian, J; Tang, Q; Wang, L; Wu, H; Yan, L; Zhang, D; Zou, X | 1 |
| Dai, X; Gui, G; Li, K; Liu, J; Xiao, Y; Yang, H | 1 |
| Alves, P; Bronze, R; Direito, R; Fernandes, A; Ferreira, RB; Figueira, ME; Lima, A; Mota, J; Pinto, R; Rebelo, P; Rocha, J; Sepodes, B | 1 |
| Barrachina, MD; Calatayud, S; Cosín-Roger, J; Esplugues, JV; Hernández, C; Macias-Ceja, DC; Ortiz-Masiá, D; Salvador, P | 2 |
| Castelucci, P; da Silva, MV; Marosti, AR; Mendes, CE; Palombit, K | 1 |
| Goto, H; Hirooka, Y; Ishiguro, K; Matsushita, M; Nakamura, M; Watanabe, O; Yamamura, T | 1 |
| Cai, Y; Chen, S; Du, C; Gao, Y; Lai, W; Qin, C; Yang, C; Zhou, J | 1 |
| Chen, JDZ; Foreman, RD; Guo, J; Jin, H; Liu, J; Lyu, B; Shi, Z; Yin, J | 1 |
| Fichtner-Feigl, S; Gerlach, K; Kindermann, M; Neurath, MF; Popp, V; Weigmann, B; Wirtz, S | 1 |
| Allred, CD; Allred, KF; Armstrong, CM; Chapkin, RS; Weeks, BR | 1 |
| Afroz, S; Khan, RA; Mallick, N; Riaz, A | 1 |
| Cai, Y; Chen, H; Li, H; Lin, YD; Sun, W; Zhang, XX | 1 |
| Han, MJ; Jang, HM; Jang, SE; Jeong, JJ; Kim, DH; Lee, HJ; Lim, SM | 1 |
| Hou, JT; Li, HW; Li, PW; Liu, FB; Mi, H | 1 |
| Banskota, S; Bist, G; Gurung, P; Kadayat, TM; Kim, JA; Lee, ES; Shrestha, A; Thapa Magar, TB | 1 |
| Chen, D; Lin, Y; Luo, D; Qiu, J; Shi, L; Wang, C; Wang, L; Xiong, Y; Zhou, Z | 1 |
| Guo, J; Jiang, M; Li, R; Liu, Y; Qin, X; Qu, Y; Song, Y; Wang, X; Yang, X; Zheng, J; Zhou, JA | 1 |
| Duarte, J; Galisteo, M; Gálvez, J; Perez-Vizcaino, F; Romero, M; Toral, M; Vera, B | 1 |
| Chen, R; Chen, X; Dong, X; Huang, X; Huang, Z; Jiang, X; Lin, H; Lin, X; Wu, X; Yang, X | 1 |
| Hua, Z; Xu, L; Yang, Y; Zhang, M; Zhang, S; Zhou, L; Zou, X | 1 |
| Fictum, P; Gajdziok, J; Hošek, J; Pokorná, M; Rotrekl, D; Šmejkal, K; Smékal, V; Suchý, P; Vochyánová, Z | 1 |
| Guan, Y; Liu, W; Pan, D; Sun, Y; Tan, Y; Wang, D; Yang, J; Zheng, C | 1 |
| Burns, P; Lavari, L; Páez, R; Reinheimer, J; Vinderola, G | 1 |
| Brichta, AM; Callister, RJ; Farrell, KE; Graham, BA; Keely, S; Walker, MM | 1 |
| Giacomin, P; Loukas, A; Miller, C; Navarro, S; Shepherd, C; Wangchuk, P | 1 |
| Chen, R; Huang, X; Huang, Z; Jiang, X; Lin, H; Zhang, W | 1 |
| Endharti, AT; Permana, S | 1 |
| Ahmetaj-Shala, B; Chang, TC; Chang, WL; Huang, SF; Lee, SY; Lin, JC; Tsai, WC | 1 |
| Alves, P; Mateus, V; Mota-Filipe, H; Pinto, R; Rocha, J; Sepodes, B | 1 |
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| Han, MJ; Hyam, SR; Jang, SE; Kim, DH; Kim, SY; Lee, BG | 1 |
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| Bernier, SG; Bryant, AP; Bueno, L; Currie, MG; Eutamene, H; Ge, P; Graul, C; Hannig, G; Jacobson, S; Jin, H; Kessler, MM; Kurtz, CB; Liong, E; Pezzone, MA; Reza, T; Rivers, S; Shea, C; Silos-Santiago, I; Tchernychev, B; Ustinova, EE | 1 |
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| Chang, JH; Kim, DH; Kim, JA; Ku, SK; Lee, EK; Park, S; Park, SY; Regmi, SC | 1 |
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| Aziz, M; Bôle-Feysot, C; Déchelotte, P; Guerin, C; Loeuillard, E; Marion-Letellier, R; Melchior, C; Mulder, P; Nicol, L; Savoye, G; Savoye-Collet, C; Vera, P | 1 |
| Amatucci, A; Burkly, LC; Dohi, T; Hagiwara, T; Kawamura, YI; Kawashima, R; Michaelson, J; Otsubo, T | 1 |
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| De Man, JG; De Winter, BY; Deiteren, A; Moreels, TG; Pelckmans, PA; Vermeulen, W | 1 |
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| Kong, X; Liu, J; Sha, S; Wei, N; Wu, K; Xu, B | 1 |
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| Cunha, TM; de Albuquerque Ribeiro, R; de Queiroz Cunha, F; de Sousa, RB; dos Reis Barbosa, AL; Soares, PM; Souza, MH; Torres, JN; Vale, ML | 1 |
| Cao, LY; Ding, H; Fan, WJ; Gan, HZ; Mei, Q; Xu, JM | 1 |
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| Bae, H; Cha, JM; Jang, SE; Kim, DH; Kim, HJ; Lee, CH; Lim, SJ; Min, JK; Park, JW | 1 |
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| Abdolghafari, AH; Abdollahi, M; Baeeri, M; Farzaei, MH; Ghasemi-Niri, SF; Khanavi, M; Navaei-Nigjeh, M; Rahimi, R | 1 |
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| Barbosa, JS; Brito, GA; Correia, ES; Fernandes, GC; Goes, AC; Guimaraes, SB; Lima Júnior, RC; Pinto, FM; Ribeiro, RA; Rodrigues, LV | 1 |
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| Chung, PC; Meng, QH; Yang, DH; Yu, L; Yuan, KT; Zuo, L | 1 |
| Blennerhassett, MG; Lourenssen, S; Miller, KG; Venkataramana, S | 1 |
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| González, R; Martínez-Augustin, O; Mascaraque, C; Sánchez de Medina, F; Suárez, MD; Zarzuelo, A | 1 |
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| Brito, GA; Gondim, Fde A; Marinho, LS; Matias, NS; Peixoto-Junior, AA; Rola, FH; Santos, AA; Silva, MT; Soares, PM; Viana-Cardoso, KV | 1 |
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| Brenner, M; Wang, P; Yang, WL; Zhang, Y | 1 |
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| Bastiaansen-Jenniskens, YM; Boersema, GS; Jeekel, J; Kleinrensink, GJ; Kroese, LF; Lam, KH; Lange, JF; Peppelenbosch, M; Taha, D; Vennix, S; Wu, Z | 1 |
| Liu, TJ; Shi, YY; Zhao, Q; Zhu, T | 1 |
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| Li, G; Ren, J; Tao, Q; Wang, B; Zheng, Y | 1 |
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| Chen, P; Li, YC; Toback, FG | 1 |
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| Bian, ZX; Chen, T; Kang, N; Su, M; Tang, XD; Wang, FY; Wang, XG; Zheng, YQ; Zhu, EL | 1 |
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| Ulutas, PA; Ural, M; Yaylali, A; Yildiz, G; Yildiz, Y | 1 |
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| Jeong, S; Jung, Y; Kim, MS; Kim, W; Lee, BL; Lee, S; Nam, J; Yoo, JW; Yum, S | 1 |
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| Bahremand, A; Daneshmand, A; Dehpour, AR; Fakhfouri, G; Mohammadi, H; Mousavizadeh, K; Rahimian, R; Rasouli, MR | 1 |
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| Fujita, H; Funakawa, K; Ido, A; Moriuchi, A; Numata, M; Oketani, M; Sakiyama, T; Setoyama, H; Tamai, T; Tsubouchi, H; Uto, H; Yamaji, N | 1 |
| Abdolghaffari, AH; Abdollahi, M; Atyabi, F; Baeeri, M; Baghaei, A; Dinarvand, R; Fazeli, MR; Jamalifar, H; Mahbod, M; Mahdaviani, P; Mohammadirad, A; Saadatzadeh, A | 1 |
| Bahremand, A; Dehpour, AR; Fakhfouri, G; Hashemi, S; Khorramizadeh, MR; Mehr, SE; Rahimian, R; Rasouli, MR | 1 |
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| Arribas, B; Bailón, E; Balsa, D; Camuesco, D; Comalada, M; Cueto-Sola, M; Gálvez, J; Garrido-Mesa, N; Janer, G; Merlos, M; Rodríguez-Cabezas, ME; Román, J; Xaus, J; Zarzuelo, A | 1 |
| Claes, IJ; De Keersmaecker, SC; Lebeer, S; Vanderleyden, J | 1 |
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| Brzozowski, T; Drozdowicz, D; Karczewska, E; Konturek, SJ; Krzysiek-Maczka, G; Pajdo, R; Pawlik, WW; Ptak-Belowska, A; Sliwowski, Z; Urbanczyk, K; Zwolinska-Wcislo, M | 1 |
| Bosse, T; de Jonge-Muller, ES; Duijvestein, M; Fibbe, WE; Hennink, S; Hommes, DW; Molendijk, I; Roelofs, H; te Velde, AA; van den Brink, GR; van der Weerd, L; van Zuylen, VL; Verspaget, HW; Vos, AC; Welling, MM; Wildenberg, ME | 1 |
| Ando, Y; Fukui, T; Hasegawa-Ishii, S; Hoshino, S; Ikehara, S; Inaba, M; Ito, T; Iwai, H; Kurishima, A; Li, M; Nishio, A; Okazaki, K; Shimada, A; Uchida, K; Yokoi, T | 1 |
| Cho, MH; Kim, JA; Lee, CS; Lee, J; Lee, JH; Regmi, SC; Yun, H | 1 |
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| de Villiers, WJ; Oz, HS; Zhong, J | 1 |
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| Grunwitz, CR; Kaminski, BM; Radeke, HH; Reuter, KC; Stein, J; Steinhilber, D | 1 |
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| Camargo, SM; Clevers, H; Fukamizu, A; Hanada, R; Hanada, T; Hashimoto, T; Ishiguro, H; Kuba, K; Lipinski, S; Paolino, M; Penninger, JM; Perlot, T; Rehman, A; Richter, A; Rosenstiel, P; Schreiber, S; Sigl, V; Singer, D; Trichereau, J; Verrey, F; Wild, B | 1 |
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| Gálvez, J; Garrido, M; Merlos, M; Torres, MI; Zarzuelo, A | 1 |
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| Bornstein, SR; Bouma, G; Chrousos, GP; Franchimont, D; Galon, J; Haidan, A; Wolkersdörfer, GW | 1 |
| Ajuebor, MN; Hogaboam, CM; Kunkel, SL; Proudfoot, AE; Wallace, JL | 1 |
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| Armstrong, AM; Foulkes, R; Gannon, C; Gardiner, KR; Jennings, G; Kirk, SJ | 1 |
| Depoortere, I; Peeters, TL; Van Assche, G | 1 |
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| Kondo, M; Murase, H; Naito, Y; Tanigawa, T; Yamaguchi, T; Yoshida, N; Yoshikawa, T | 1 |
| Adler, G; Bachem, M; Dikopoulos, N; Liptay, S; Nüssler, AK; Reinshagen, M; Schmid, RM; Stiegler, M; Weidenbach, H | 1 |
| Anderson, DC; Elena, M; Gironella, M; Panés, J; Piqué, JM; Pizcueta, P; Prats, N; Salas, A; Sans, M; Soriano, A | 1 |
| Crespo, E; Cruz, T; Gálvez, J; Ocete, MA; Zarzuelo, A | 1 |
| Auwerx, J; Chambon, P; Colombel, JF; Derijard, B; Desreumaux, P; Desvergne, B; Dubuquoy, L; Englaro, W; Leibowitz, MD; Nutten, S; Peuchmaur, M; Schoonjans, K; Wahli, W | 1 |
| Bossone, C; Hosseini, JM; Piñeiro-Carrero, V; Shea-Donohue, T | 1 |
| Chin, JE; Krzesicki, RF; Lai, PS; Nagele, RG; Sun, FF; Tong, DM; Wong, PY; Yin, K; Yue, G | 1 |
| Lai, PS; Lin, KT; Linask, KK; Liu, X; Nagele, RG; Sun, FF; Wang, C; Wong, PY; Yin, K; Yue, G | 1 |
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| Boerman, OC; Corstens, FH; Gratz, S; Oyen, WJ; Rennen, HJ | 1 |
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| Gerken, G; Goebell, H; Hoffmann, P; Reinshagen, M; Riley, NE; Zeeh, JM | 1 |
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| Kankuri, E; Knowles, RG; Korpela, R; Lähde, M; Moilanen, E; Vaali, K; Vapaatalo, H | 1 |
| Appleyard, CB; Asfaha, S; Chadee, K; MacNaughton, WK; Wallace, JL | 1 |
| Fuss, I; Kitani, A; Strober, W | 1 |
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| Akira, S; Hibi, T; Iiyama, R; Ikeda, M; Ishii, H; Kanai, T; Kurimoto, M; Okamoto, R; Okamoto, S; Okazawa, A; Sato, T; Takeda, K; Totsuka, T; Watanabe, M; Yamazaki, M | 1 |
| Azooz, OG; Ballinger, AB; Farthing, MJ; Savage, MO | 1 |
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| Coruzzi, G; Grandi, D; Lazzaretti, M; Poli, E; Pozzoli, C | 1 |
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| Cirino, G; Distrutti, E; Fiorucci, S; Hollenberg, MD; Mencarelli, A; Morelli, A; Palazzetti, B; Vergnolle, N; Wallace, JL | 1 |
| Aloni, S; Amitai, H; Belzer, I; Chvatchko, Y; Corbaz, A; Drillenburg, P; Graber, P; Te Velde, AA; Ten Hove, T; van Deventer, SJ | 1 |
| Coelho, G; Concha, A; Crespo, ME; Cruz, T; Gálvez, J; Gonzalez, M; Rodríguez-Cabezas, ME; Zarzuelo, A | 1 |
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| Antolín, M; Guarner, F; Malagelada, JR; Medina, C; Radomski, A; Radomski, M; Salas, A; Videla, S; Vilaseca, J | 1 |
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| Drillenburg, P; Peppelenbosch, MP; Pronk, I; ten Hove, T; van den Blink, B; van Deventer, SJ | 1 |
| Alexander, JS; Carter, P; Coe, L; Grisham, MB; Hsia, CJ; Liu, JE; Ma, JW; Ma, L; Oshima, T; Park, JH; Specian, R; Trimble, CE | 1 |
| Depoortere, I; Peeters, TL; Thijs, T | 1 |
| Coruzzi, G; Grandi, D; Lazzaretti, M; Nosalova, V; Poli, E; Pozzoli, C; Schunack, W | 1 |
| Barth, S; Diehl, V; Ecker, KW; Engert, A; Huhn, M; Jüngling, B; Mueller-Molaian, I; Pfister, K; Sasse, S; Stallmach, A; Wittig, BM; Zeitz, M | 1 |
| Fantuzzi, G; Lehr, HA; Siegmund, B | 1 |
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| Inamori, M; Nagase, H; Naito, M; Nakajima, A; Saito, T; Sato, S; Sekihara, H; Tanaka, K; Togawa, J; Umezawa, T | 1 |
| Asaka, M; Hige, S; Iwanaga, T; Kato, M; Mizue, Y; Nakamura, H; Nishihira, J; Ohkawara, T; Sugiyama, T; Takeda, H | 1 |
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| Guarner, F; Malagelada, JR; Rodriguez, R; Salas, A; Vilaseca, J | 1 |
| Allgayer, H; Deschryver, K; Stenson, WF | 1 |
| Fondacaro, JD; Griswold, DE; Rachmilewitz, D; Schwartz, LW; Simon, PL; Wasserman, MA | 1 |
| Evangelista, S; Meli, A | 1 |
| Wallace, JL | 1 |
10 review(s) available for trinitrobenzenesulfonic acid and Colitis
| Article | Year |
|---|---|
Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2022 |
Human Relevance of Preclinical Studies on the Skeletal Impact of Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.
Topics: Animals; Bone Diseases, Metabolic; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Trinitrobenzenesulfonic Acid | 2021 |
Quality of methods reporting in animal models of colitis.
Topics: Animals; Checklist; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-10; Leukocyte Common Antigens; Research Design; Trinitrobenzenesulfonic Acid | 2015 |
Lessons from probiotic-host interaction studies in murine models of experimental colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-10; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Probiotics; Trinitrobenzenesulfonic Acid | 2011 |
Assessment of anticolitic drugs in the trinitrobenzene sulfonic acid (TNBS) rat model of inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Arginine; Blotting, Western; Colitis; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; Inflammatory Bowel Diseases; Injections, Subcutaneous; Instillation, Drug; Male; Models, Animal; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2003 |
[Real time PCR: principle and usage].
Topics: Animals; Colitis; Computer Systems; Disease Models, Animal; Granulocyte-Macrophage Colony-Stimulating Factor; Intestinal Mucosa; Polymerase Chain Reaction; Rats; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2004 |
Insights into the mechanism of oral tolerance derived from the study of models of mucosal inflammation.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Immune Tolerance; Immunity, Mucosal; Inflammation; Mice; Mouth Mucosa; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2004 |
Critical appraisal of the current practice in murine TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Hypersensitivity; Gene Expression Profiling; Health Planning Guidelines; Humans; Hypersensitivity, Delayed; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 2006 |
Therapeutic potential of Yersinia anti-inflammatory components.
Topics: Animals; Antigens, Bacterial; Colitis; Humans; Inflammation; Inflammatory Bowel Diseases; Lactococcus lactis; Mice; Pore Forming Cytotoxic Proteins; Trinitrobenzenesulfonic Acid; Virulence Factors; Yersinia | 2007 |
TNBS-colitis.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Humans; Trinitrobenzenesulfonic Acid | 2000 |
6 trial(s) available for trinitrobenzenesulfonic acid and Colitis
| Article | Year |
|---|---|
Contribution of the Gut Microbiota in P28GST-Mediated Anti-Inflammatory Effects: Experimental and Clinical Insights.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Colitis; Crohn Disease; Fecal Microbiota Transplantation; Feces; Female; Gastrointestinal Microbiome; Glutathione Transferase; Humans; Immunization; Immunomodulation; Mice, Inbred BALB C; Phenotype; Trinitrobenzenesulfonic Acid | 2019 |
Pulsatile systems for colon targeting of budesonide: in vitro and in vivo evaluation.
Topics: Administration, Oral; Adult; Animals; Biological Availability; Budesonide; Capsules; Cellulose; Chemistry, Pharmaceutical; Colitis; Colon; Colon, Transverse; Delayed-Action Preparations; Galactans; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Hypromellose Derivatives; Ileum; Lactose; Male; Mannans; Mannosidases; Methylcellulose; Pectins; Peroxidase; Plant Gums; Polygalacturonase; Polymethacrylic Acids; Rabbits; Radiography; Rectum; Stomach; Tablets; Trinitrobenzenesulfonic Acid; Young Adult | 2011 |
Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis.
Topics: Adolescent; Adult; Aged; Amides; Animals; Cells, Cultured; Colitis; Crohn Disease; Cytokines; Enzyme Inhibitors; Female; Humans; I-kappa B Kinase; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Leukocytes, Mononuclear; Male; Middle Aged; NF-kappa B; Prospective Studies; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Trinitrobenzenesulfonic Acid | 2003 |
RDP58, a novel immunomodulatory peptide with anti-inflammatory effects. A pharmacological study in trinitrobenzene sulphonic acid colitis and Crohn disease.
Topics: Adolescent; Adult; Aged; Animals; Anti-Inflammatory Agents; Colitis; Crohn Disease; Female; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Interleukin-1; Intestinal Mucosa; Male; Middle Aged; Models, Animal; Peptides; Prospective Studies; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Prediction of antitumour necrosis factor clinical efficacy by real-time visualisation of apoptosis in patients with Crohn's disease.
Topics: Adult; Animals; Annexin A5; Antibodies, Monoclonal; Apoptosis; CD4-Positive T-Lymphocytes; Colitis; Crohn Disease; Disease Models, Animal; Female; Gastrointestinal Agents; Humans; Infliximab; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Middle Aged; Organotechnetium Compounds; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Butyrate enema therapy stimulates mucosal repair in experimental colitis in the rat.
Topics: Animals; Butyrates; Colitis; Colon; Disease Models, Animal; Enema; Ion Transport; Male; Mucous Membrane; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
1466 other study(ies) available for trinitrobenzenesulfonic acid and Colitis
| Article | Year |
|---|---|
Bacteria-Derived Compatible Solutes Ectoine and 5α-Hydroxyectoine Act as Intestinal Barrier Stabilizers to Ameliorate Experimental Inflammatory Bowel Disease.
Topics: Amino Acids, Diamino; Animals; Bacteria; Colitis; Colon; Egypt; Glutathione; Humans; Inflammatory Bowel Diseases; Intercellular Adhesion Molecule-1; Interleukin-1beta; Intestines; Male; Molecular Structure; Peroxidase; Rats; Rats, Wistar; Solutions; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Colonic inflammation induces changes in glucose levels through modulation of incretin system.
Topics: Adult; Animals; Blood Glucose; Case-Control Studies; Colitis; Crohn Disease; Dipeptidyl Peptidase 4; Disease Models, Animal; Female; Glucagon-Like Peptide 1; Humans; Incretins; Inflammation; Male; Mice; Mice, Inbred C57BL; Middle Aged; Proprotein Convertase 1; Trinitrobenzenesulfonic Acid; Young Adult | 2021 |
Intracolic ultrasound molecular imaging: a novel method for assessing colonic tumor necrosis factor-α expression in inflammatory bowel disease.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fluorescent Antibody Technique; Gene Expression; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Linear Models; Male; Mice, Inbred BALB C; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Ultrasonography | 2021 |
Olaparib: A Clinically Applied PARP Inhibitor Protects from Experimental Crohn's Disease and Maintains Barrier Integrity by Improving Bioenergetics through Rescuing Glycolysis in Colonic Epithelial Cells.
Topics: Animals; Colitis; Colon; Crohn Disease; Energy Metabolism; Epithelial Cells; Glycolysis; Male; Mice; Oxidative Stress; Permeability; Phthalazines; Piperazines; Poly(ADP-ribose) Polymerase Inhibitors; Trinitrobenzenesulfonic Acid | 2021 |
Design and evaluation of IKK-activated GSK3β inhibitory peptide as an inflammation-responsive anti-colitic therapeutic.
Topics: Animals; Colitis; Glycogen Synthase Kinase 3 beta; Inflammation; Peptides; Rats; Trinitrobenzenesulfonic Acid | 2021 |
Magnetic resonance colonography assessment of acute trinitrobenzene sulfonic acid colitis in pre-pubertal rats.
Topics: Animals; Colitis; Cyclooxygenase 2; Disease Models, Animal; Interleukin-1beta; Magnetic Resonance Imaging; Male; Mice; Nitric Oxide Synthase Type II; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation.
Topics: Alkanesulfonic Acids; Animals; Colitis; Cytokines; Disease Models, Animal; Fluorocarbons; Homeostasis; Inflammation; Intestinal Mucosa; Mice; Trinitrobenzenesulfonic Acid; Zebrafish | 2021 |
Protein Kinase CK2 Maintains Reciprocal Balance Between Th17 and Treg Cells in the Pathogenesis of UC.
Topics: Animals; Casein Kinase II; Colitis; Colitis, Ulcerative; Humans; Mice; Sirtuin 1; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2022 |
Protein Kinase CK2 Acts as a Molecular Brake to Control NADPH Oxidase 1 Activation and Colon Inflammation.
Topics: Animals; Casein Kinase II; Colitis; Inflammation; Inflammatory Bowel Diseases; Mice; NADPH Oxidase 1; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2022 |
Long-term exclusive enteral nutrition remodels the gut microbiota and alleviates TNBS-induced colitis in mice.
Topics: Animals; Colitis; Enteral Nutrition; Female; Gastrointestinal Microbiome; Male; Mice; Mice, Inbred C57BL; Time Factors; Trinitrobenzenesulfonic Acid | 2022 |
Rectal roflumilast improves trinitrobenzenesulfonic acid-induced chronic colitis in rats.
Topics: Aminopyridines; Animals; Benzamides; Colitis; Cyclopropanes; Disease Models, Animal; Mice; Peroxidase; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Efficacy of a functional food ingredient from
Topics: Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Food Ingredients; Functional Food; Mice; NF-kappa B; Plant Extracts; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Mesenchymal Stem Cells Alleviate Inflammatory Bowel Disease Via Tr1 Cells.
Topics: Animals; Colitis; Dioxygenases; Humans; Inflammatory Bowel Diseases; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2022 |
A TNBS-Induced Rodent Model to Study the Pathogenic Role of Mechanical Stress in Crohn's Disease.
Topics: Animals; Colitis; Colon; Crohn Disease; Disease Models, Animal; Rats; Rats, Sprague-Dawley; Rodentia; Stress, Mechanical; Trinitrobenzenesulfonic Acid | 2022 |
Peptide YY 3-36 attenuates trinitrobenzene sulfonic acid-induced colitis in mice by modulating Th1/Th2 differentiation.
Topics: Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Interleukin-6; Mice; Mice, Inbred BALB C; Peptide YY; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Protective Effect of Nanoparticles from Platycladi Cacumen Carbonisata on 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colitis, Ulcerative; Nanoparticles; Rats; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2022 |
Deficiency in glutathione synthesis and reduction contributes to the pathogenesis of colitis-related liver injury.
Topics: Animals; Antioxidants; Aspartate Aminotransferases; Colitis; Colitis, Ulcerative; Colon; Glutathione; Liver; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Chronic Experimental Model of TNBS-Induced Colitis to Study Inflammatory Bowel Disease.
Topics: Animals; Chronic Disease; Colitis; Colon; Disease Models, Animal; Ethanol; Female; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Topics: Animals; Bacillus amyloliquefaciens; Camelus; Colitis; Colon; Cytokines; Disease Models, Animal; Mice; Milk; Peroxidase; Proliferating Cell Nuclear Antigen; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Endoplasmic reticulum stress contributed to inflammatory bowel disease by activating p38 MAPK pathway.
Topics: Animals; Colitis; Endoplasmic Reticulum Stress; Humans; Inflammatory Bowel Diseases; Interleukin-8; Mice; p38 Mitogen-Activated Protein Kinases; Trinitrobenzenesulfonic Acid; Tunicamycin | 2022 |
Protective effect of fermented okara on the regulation of inflammation, the gut microbiota, and SCFAs production in rats with TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Dietary Fiber; Fatty Acids, Volatile; Gastrointestinal Microbiome; Inflammation; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Olmesartan medoxomil self-microemulsifying drug delivery system reverses apoptosis and improves cell adhesion in trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cadherins; Caspase 3; Cell Adhesion; Colitis; Crohn Disease; Drug Delivery Systems; Interleukin-6; Malondialdehyde; Matrix Metalloproteinase 9; Olmesartan Medoxomil; Peroxidase; Rats; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Polydatin alleviates DSS- and TNBS-induced colitis by suppressing Th17 cell differentiation via directly inhibiting STAT3.
Topics: Animals; Cell Differentiation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Glucosides; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; STAT3 Transcription Factor; Stilbenes; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2022 |
Buspirone Ameliorates Colon Inflammation in TNBS-Induced Rat Acute Colitis: The Involvement of TLR4/NF-kB Pathway.
Topics: Animals; Anti-Inflammatory Agents; Buspirone; Colitis; Colon; Dexamethasone; Disease Models, Animal; Inflammation; Male; NF-kappa B; Rats; Rats, Wistar; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis.
Topics: Animals; Autophagy; Basigin; Colitis; Collagen; Colon; Disease Models, Animal; Ethanol; Fibrosis; Mice; Phenols; RNA, Messenger; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2022 |
Citation: Tight Junction Protein Expression-Inducing Probiotics Alleviate TNBS-Induced Cognitive Impairment with Colitis in Mice.
Topics: Animals; Caco-2 Cells; Claudin-1; Claudin-5; Cognitive Dysfunction; Colitis; Humans; Inflammation; Interleukin-10; Lipopolysaccharides; Mice; NF-kappa B; Probiotics; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
The ethanol extract of Periplaneta Americana L. improves ulcerative colitis induced by a combination of chronic stress and TNBS in rats.
Topics: Adrenocorticotropic Hormone; Animals; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Enema; Ethanol; Periplaneta; Plant Extracts; Rats; Trinitrobenzenesulfonic Acid | 2022 |
Anti-Inflammatory Effect of Topiramate in a Chronic Model of TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Leukocyte L1 Antigen Complex; Mice; Topiramate; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Mesenchymal stem cell transplantation worsens intestinal inflammation and microenvironment in PI3Kγ-knockout mice.
Topics: Animals; Benzene; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Cytokines; Disease Models, Animal; Immunoglobulin A; Inflammation; Interleukin-10; Mesenchymal Stem Cell Transplantation; Mice; Mice, Inbred C57BL; Mice, Knockout; Occludin; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid | 2022 |
Rapamycin Alleviates 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis through Autophagy Induction and NF-
Topics: Animals; Autophagy; Colitis; Inflammation; Lipopolysaccharides; Mice; NF-kappa B; Sirolimus; Trinitrobenzenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2022 |
Human umbilical cord-derived mesenchymal stem cells ameliorate experimental colitis by normalizing the gut microbiota.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Humans; Mesenchymal Stem Cells; Mice; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2022 |
BMSCs improve TNBS-induced colitis in rats by inducing Treg differentiation by expressing PD-L1.
Topics: Animals; B7-H1 Antigen; Bone Marrow Cells; Cell Differentiation; Colitis; Mesenchymal Stem Cell Transplantation; Phosphates; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; T-Lymphocytes, Regulatory; TOR Serine-Threonine Kinases; Trinitrobenzenesulfonic Acid | 2022 |
Oral supplementation with selected Lactobacillus acidophilus triggers IL-17-dependent innate defense response, activation of innate lymphoid cells type 3 and improves colitis.
Topics: Animals; Bifidobacterium animalis; Colitis; Enterobacteriaceae Infections; Immunity, Innate; Inflammation; Inflammatory Bowel Diseases; Interleukin-17; Lactobacillus acidophilus; Lymphocytes; Mice; Probiotics; Trinitrobenzenesulfonic Acid | 2022 |
Comparison of the safety and efficacy of fingolimod and tofacitinib in the zebrafish model of colitis.
Topics: Animals; Colitis; Fingolimod Hydrochloride; Inflammatory Bowel Diseases; Myeloid Differentiation Factor 88; Trinitrobenzenesulfonic Acid; Zebrafish | 2022 |
Electrolyzed Hydrogen Water Alleviates Abdominal Pain through Suppression of Colonic Tissue Inflammation in a Rat Model of Inflammatory Bowel Disease.
Topics: Abdominal Pain; Animals; Colitis; Colon; Hydrogen; Inflammation; Inflammatory Bowel Diseases; Rats; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid; Water | 2022 |
Efficacy and safety of erythropoietin in a chronic model of Inflammatory Bowel Disease.
Topics: Animals; Anti-Inflammatory Agents; Chronic Disease; Colitis; Erythropoietin; Graft vs Host Disease; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2022 |
A Chemically Induced Experimental Colitis Model with a Simple Combination of Acetic Acid and Trinitrobenzene Sulphonic Acid.
Topics: Acetic Acid; Animals; Colitis; Colon; Inflammation; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2023 |
Immunohistochemical characterization of transient receptor potential vanilloid types 2 and 1 in a trinitrobenzene sulfonic acid-induced rat colitis model with visceral hypersensitivity.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Ganglia, Spinal; Neurons; Rats; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2023 |
Radix Panacis quinquefolii Extract Ameliorates Inflammatory Bowel Disease through Inhibiting Inflammation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Lipopolysaccharides; Trinitrobenzenesulfonic Acid; Zebrafish | 2023 |
Effect of exogenous galectin-9, a natural TIM-3 ligand, on the severity of TNBS- and DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Galectins; Hepatitis A Virus Cellular Receptor 2; Inflammatory Bowel Diseases; Interleukin-6; Ligands; Mice; Mice, Inbred C57BL; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2023 |
Effect of soluble oat fiber on intestinal microenvironment and TNBS-induced colitis.
Topics: Animals; Avena; Butyrates; Colitis; Disease Models, Animal; Inflammation; Trinitrobenzenesulfonic Acid | 2023 |
Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance.
Topics: Animals; Colitis; Colitis, Ulcerative; Cytokines; Forkhead Transcription Factors; Interleukin-10; Interleukin-17; Interleukin-4; Mice; Nuclear Receptor Subfamily 1, Group F, Member 3; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2023 |
Response Variability to Drug Testing in Two Models of Chemically Induced Colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Male; Mice; Trinitrobenzenesulfonic Acid | 2023 |
Oxyberberine ameliorates TNBS-induced colitis in rats through suppressing inflammation and oxidative stress via Keap1/Nrf2/NF-κB signaling pathways.
Topics: Animals; Colitis; Colitis, Ulcerative; Follow-Up Studies; Inflammation; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; NF-kappa B; Oxidative Stress; Rats; Signal Transduction; Trinitrobenzenesulfonic Acid | 2023 |
Lactic Acid Bacteria Isolated from Human Breast Milk Improve Colitis Induced by 2,4,6-Trinitrobenzene Sulfonic Acid by Inhibiting NF-κB Signaling in Mice.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Cytokines; Female; Humans; Inflammatory Bowel Diseases; Lactobacillales; Mice; Milk, Human; NF-kappa B; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2023 |
Mechanism by which oleracein E alleviates TNBS-induced ulcerative colitis.
Topics: Animals; Caco-2 Cells; Colitis; Colitis, Ulcerative; Humans; Interleukin-6; Lipopolysaccharides; NF-E2-Related Factor 2; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2023 |
Dynamic alterations in metabolomics and transcriptomics associated with intestinal fibrosis in a 2,4,6-trinitrobenzene sulfonic acid-induced murine model.
Topics: Animals; Colitis; Disease Models, Animal; Metabolomics; Mice; Transcriptome; Trinitrobenzenesulfonic Acid | 2023 |
Human umbilical cord mesenchymal stem cells alleviated TNBS-induced colitis in mice by restoring the balance of intestinal microbes and immunoregulation.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Humans; Immunity; Inflammatory Bowel Diseases; Mesenchymal Stem Cells; Mice; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2023 |
Inflammation-induced Occludin Downregulation Limits Epithelial Apoptosis by Suppressing Caspase-3 Expression.
Topics: Animals; Apoptosis; Caco-2 Cells; Case-Control Studies; Caspase 3; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Humans; Intestinal Mucosa; Mice, Inbred C57BL; Mice, Knockout; Occludin; Signal Transduction; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2019 |
High-fat diet promotes experimental colitis by inducing oxidative stress in the colon.
Topics: Animals; Cell Line; Cholesterol; Colitis; Colon; Cytokines; Diet, High-Fat; Epithelial Cells; Fatty Acids, Nonesterified; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Myosin-Light-Chain Kinase; Oxidative Stress; Reactive Oxygen Species; Triglycerides; Trinitrobenzenesulfonic Acid | 2019 |
Evaluation of the effect of liposomes loaded with chlorogenic acid in treatment of 2,4,6-trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Liposomes; Male; Mesalamine; Mice; Mice, Inbred BALB C; Peroxidase; Quality of Life; Trinitrobenzenesulfonic Acid | 2019 |
Changes in colonic contractility in response to inflammatory bowel disease: Long-term assessment in a model of TNBS-induced inflammation in rats.
Topics: Animals; Colitis; Disease Models, Animal; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Muscle Contraction; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2019 |
Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils.
Topics: Animals; Cell Line, Tumor; Cells, Cultured; Colitis; Cytosol; Enzyme Activation; Female; Humans; Male; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; Neutrophils; Proliferating Cell Nuclear Antigen; Protein Binding; Reactive Oxygen Species; Small Molecule Libraries; Trinitrobenzenesulfonic Acid | 2019 |
Protective effect of adipose tissue-derived mesenchymal stromal cells in an experimental model of high-risk colonic anastomosis.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colitis; Colon; Disease Models, Animal; Humans; Intra-Abdominal Fat; Male; Mesenchymal Stem Cell Transplantation; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2019 |
Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Intestinal Mucosa; Intestines; Mice; Sirolimus; Trinitrobenzenesulfonic Acid | 2019 |
Inactive Rhomboid Protein 2 Mediates Intestinal Inflammation by Releasing Tumor Necrosis Factor-α.
Topics: Animals; Carrier Proteins; Colitis; Cytokines; Inflammation; Intestines; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxidative Stress; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Beneficial Effects of Oat Beta-Glucan Dietary Supplementation in Colitis Depend on its Molecular Weight.
Topics: Animals; Anti-Inflammatory Agents; Avena; beta-Glucans; Colitis; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Regulation; Lymphocyte Count; Male; Molecular Weight; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2019 |
Evaluation of the therapeutic activity of melatonin and resveratrol in Inflammatory Bowel Disease: A longitudinal PET/CT study in an animal model.
Topics: Animals; Antioxidants; Colitis; Colon; Melatonin; Positron Emission Tomography Computed Tomography; Rats, Sprague-Dawley; Resveratrol; Trinitrobenzenesulfonic Acid | 2019 |
Amelioration of colitis in mice by Leuconostoc lactis EJ-1 by M1 to M2 macrophage polarization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-1beta; Interleukin-6; Leuconostoc; Lipopolysaccharides; Macrophages, Peritoneal; Mice; NF-kappa B; Plants, Edible; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Topics: Administration, Oral; Animals; Bacterial Adhesion; Caco-2 Cells; Colitis; Colon; Cyclooxygenase 2; Cytokines; Humans; Latilactobacillus sakei; Male; Mice; Mice, Inbred ICR; NF-kappa B; Nitric Oxide Synthase Type II; Probiotics; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Uncoupling of Carbonic Anhydrase from Na-H exchanger-1 in Experimental Colitis: A Possible Mechanistic Link with Na-H Exchanger.
Topics: Animals; Binding Sites; Carbonic Anhydrases; Colitis; Colon; Disease Models, Animal; Down-Regulation; Ileum; Injections, Spinal; Male; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Comparison of the fecal, cecal, and mucus microbiome in male and female mice after TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Male; Mice; Microbiota; Mucous Membrane; Trinitrobenzenesulfonic Acid | 2019 |
Resveratrol Downregulates miR-31 to Promote T Regulatory Cells during Prevention of TNBS-Induced Colitis.
Topics: Animals; Case-Control Studies; Colitis; Colitis, Ulcerative; Down-Regulation; Female; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Mice, Inbred C57BL; MicroRNAs; Resveratrol; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2020 |
Aqueous Extract of Brazilian Berry (
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Colitis; Fruit; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Myrtaceae; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2019 |
Sauchinone ameliorates intestinal inflammation and promotes Th17 cell production of IL-10 via Blimp-1.
Topics: Animals; Benzopyrans; Colitis; Dioxoles; Humans; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Intestines; Mice; Positive Regulatory Domain I-Binding Factor 1; Signal Transduction; Th17 Cells; Trinitrobenzenesulfonic Acid | 2020 |
Nod2 Protects the Gut From Experimental Colitis Spreading to Small Intestine.
Topics: Animals; Cecum; Colitis; Crohn Disease; Duodenitis; Duodenum; Gene Expression; Humans; Ileitis; Ileum; Interferon-gamma; Interleukin-12; Intestinal Mucosa; Mice; Mice, Knockout; Nod2 Signaling Adaptor Protein; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Effects of O-1602 and CBD on TNBS-induced colonic disturbances.
Topics: Animals; Cannabidiol; Colitis; Gastrointestinal Transit; Inflammation; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Trinitrobenzenesulfonic Acid | 2020 |
Immunomodulatory Effect of Urine-derived Stem Cells on Inflammatory Bowel Diseases via Downregulating Th1/Th17 Immune Responses in a PGE2-dependent Manner.
Topics: Adult; Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cells, Cultured; Coculture Techniques; Colitis; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dinoprostone; Down-Regulation; Gene Knockdown Techniques; Humans; Immunomodulation; Inflammatory Bowel Diseases; Lymphocyte Activation; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Phytohemagglutinins; Stem Cell Transplantation; Stem Cells; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Urine; Young Adult | 2020 |
Altered microbial community structure in PI3Kγ knockout mice with colitis impeding relief of inflammation: Establishment of new indices for intestinal microbial disorder.
Topics: Animals; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Mice, Knockout; Microbiota; RNA, Ribosomal, 16S; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
The Chinese medicinal herb decoction QRZSLXF enhances anti-inflammatory effect in TNBS-induced colitis via balancing Th17/Tregs differentiation.
Topics: Animals; Anti-Inflammatory Agents; beta-Naphthoflavone; Cell Differentiation; Colitis; Dexamethasone; Drugs, Chinese Herbal; Male; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2020 |
Low-dose curcumin reduced TNBS-associated mucin depleted foci in mice by scavenging superoxide anion and lipid peroxides, rebalancing matrix NO synthase and aconitase activities, and recoupling mitochondria.
Topics: Aconitate Hydratase; Animals; Apoptosis; Colitis; Colon; Curcumin; Inflammatory Bowel Diseases; Intestinal Mucosa; Lipid Peroxides; Male; Mice; Mitochondria; Mucins; Nitric Oxide Synthase; Oxidation-Reduction; Peroxidase; Reactive Oxygen Species; Superoxides; Trinitrobenzenesulfonic Acid | 2020 |
Gabapentin attenuates intestinal inflammation: Role of PPAR-gamma receptor.
Topics: Animals; Benzhydryl Compounds; Colitis; Cytokines; Gabapentin; Glutathione; Intestinal Mucosa; Male; Malondialdehyde; Mast Cells; NF-kappa B; Peroxidase; Phenols; PPAR gamma; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Therapeutic effects of combination of platelet lysate and sulfasalazine administration in TNBS-induced colitis in rat.
Topics: Animals; Apoptosis; Blood Platelets; Colitis; Combined Modality Therapy; Cytokines; Disease Models, Animal; Gastrointestinal Agents; Inflammatory Bowel Diseases; Male; NF-kappa B; Rats; Rats, Wistar; Signal Transduction; Sulfasalazine; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2020 |
Anti-inflammatory effects of sacral nerve stimulation: a novel spinal afferent and vagal efferent pathway.
Topics: Animals; Colitis; Efferent Pathways; Inflammation; Male; Rats; Rats, Sprague-Dawley; Sacrum; Spinal Nerves; Trinitrobenzenesulfonic Acid; Vagus Nerve | 2020 |
The Proteolytic Fraction From Vasconcellea cundinamarcensis Latex Displays Anti-Inflammatory Effect in A Mouse Model of Acute TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Caricaceae; Colitis; Colon; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Hexosaminidases; Humans; Inflammation Mediators; Latex; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Peroxidase; Proteolysis; Trinitrobenzenesulfonic Acid; Weight Loss | 2020 |
Effect of T. spiralis Serine protease inhibitors on TNBS-induced experimental colitis mediated by Macrophages.
Topics: Animals; Arginase; Autoimmunity; Colitis; Disease Models, Animal; Inflammation; Interleukin-33; Janus Kinase 2; Macrophages; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Phenotype; Phosphorylation; Recombinant Proteins; Serine Proteinase Inhibitors; STAT3 Transcription Factor; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2020 |
Grape peel powder attenuates the inflammatory and oxidative response of experimental colitis in rats by modulating the NF-κB pathway and activity of antioxidant enzymes.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Cytokines; Dietary Fiber; Fruit; Inflammation; Lipid Peroxidation; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Phytotherapy; Plant Extracts; Polyphenols; Rats, Wistar; Signal Transduction; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Vitis | 2020 |
Lactobacillus reuteri 5454 and Bifidobacterium animalis ssp. lactis 5764 improve colitis while differentially impacting dendritic cells maturation and antimicrobial responses.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium animalis; Citrobacter rodentium; Colitis; Dendritic Cells; Disease Models, Animal; Enterobacteriaceae Infections; Female; Gastrointestinal Microbiome; Germ-Free Life; Limosilactobacillus reuteri; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Pancreatitis-Associated Proteins; Probiotics; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2020 |
Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Colonic Diseases; Cytokines; Disease Models, Animal; Diterpenes; Epithelium; Female; Fibrosis; Inflammation; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; T-Lymphocyte Subsets; Trinitrobenzenesulfonic Acid | 2020 |
miR-340 affects sauchinone inhibition of Th17 cell differentiation and promotes intestinal inflammation in inflammatory bowel disease.
Topics: Base Sequence; Benzopyrans; Cell Cycle Proteins; Cell Differentiation; Colitis; Dioxoles; Disease Susceptibility; DNA-Binding Proteins; Down-Regulation; Forkhead Transcription Factors; Humans; Inflammation; Inflammatory Bowel Diseases; Intestines; MicroRNAs; Nuclear Proteins; Severity of Illness Index; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Up-Regulation | 2020 |
Mitochondrial bioenergetics, uncoupling protein-2 activity, and reactive oxygen species production in the small intestine of a TNBS-induced colitis rat model.
Topics: Animals; Colitis; Disease Models, Animal; Energy Metabolism; Inflammation; Intestine, Small; Mitochondria; Oxidative Stress; Oxygen Consumption; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid; Uncoupling Protein 2 | 2020 |
Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates 2,4,6-trinitrobenzenesulfonic acid-induced colitis via repressing toll-like receptor 4/nuclear factor-kappa B.
Topics: Adenoviridae; Animals; Body Weight; Chemokine CCL2; Colitis; Colon; Gene Expression Regulation; Genetic Vectors; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-1beta; Interleukin-6; Male; NF-kappa B; PCSK9 Inhibitors; Peroxidase; Proprotein Convertase 9; Rats; Rats, Wistar; RNA, Small Interfering; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Evaluation of protein arginine deiminase-4 inhibitor in TNBS- induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Extracellular Traps; Female; Mice, Inbred BALB C; Ornithine; Protein-Arginine Deiminase Type 4; Trinitrobenzenesulfonic Acid | 2020 |
Effects of Yacon on Colonic IFN-γ and Goblet Cells of 2,4,6-Trinitrobenzene Sulfonic Acid-Induced Colitis Mouse Model.
Topics: Animals; Cell Count; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Goblet Cells; Interferon-gamma; Male; Mice, Inbred BALB C; Plant Tubers; Trinitrobenzenesulfonic Acid | 2020 |
Invasive Lactococcus lactis producing mycobacterial Hsp65 ameliorates intestinal inflammation in acute TNBS-induced colitis in mice by increasing the levels of the cytokine IL-10 and secretory IgA.
Topics: Administration, Oral; Animals; Bacterial Proteins; Caco-2 Cells; Chaperonin 60; Colitis; Drug Delivery Systems; Female; Humans; Immunoglobulin A, Secretory; Inflammation; Interleukin-10; Lactococcus lactis; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid | 2020 |
Lessons on the Sigma-1 Receptor in TNBS-Induced Rat Colitis: Modulation of the UCHL-1, IL-6 Pathway.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Disease Susceptibility; Fluvoxamine; Gene Expression Regulation; Heme Oxygenase (Decyclizing); Inflammation Mediators; Interleukin-6; Ligands; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Protein Binding; Rats; Receptors, sigma; Severity of Illness Index; Sigma-1 Receptor; Signal Transduction; Trinitrobenzenesulfonic Acid; Ubiquitin Thiolesterase | 2020 |
Elucidation of colon-protective efficacy of diosgenin in experimental TNBS-induced colitis: inhibition of NF-κB/IkB-α and Bax/Caspase-1 signaling pathways.
Topics: Animals; bcl-2-Associated X Protein; Biomarkers; Caspase 1; Colitis; Colon; Cytoprotection; Diosgenin; Disease Models, Animal; Male; NF-kappa B; NF-KappaB Inhibitor alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
Sacral nerve stimulation ameliorates colonic barrier functions in a rodent model of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Electric Stimulation Therapy; Electrodes, Implanted; Lumbosacral Plexus; Male; Rats; Rats, Sprague-Dawley; Rodentia; Trinitrobenzenesulfonic Acid | 2020 |
The effect of Hericium erinaceum on the prevention of chemically induced experimental colitis in rats.
Topics: Animals; Colitis; Colon; Hericium; NF-kappa B; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
Effect of recombinant serine protease from newborn larval stage of Trichinella spiralis on 2,4,6-trinitrobenzene sulfonic acid-induced experimental colitis in mice.
Topics: Animals; Colitis; Cytokines; Female; Larva; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Recombinant Proteins; Serine Proteases; T-Lymphocytes, Regulatory; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2020 |
Effect of recombinant serine protease from adult stage of Trichinella spiralis on TNBS-induced experimental colitis in mice.
Topics: Aging; Animals; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; Helminth Proteins; Mice, Inbred BALB C; Recombinant Proteins; Serine Proteases; Spleen; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Th2 Cells; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2020 |
Beneficial effect of Bidens pilosa L. (Asteraceae) in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bidens; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Inflammation; Leukocytes; Oxidative Stress; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2020 |
Transcriptome Based Profiling of the Immune Cell Gene Signature in Rat Experimental Colitis and Human IBD Tissue Samples.
Topics: Adult; Aged; Animals; Biopsy; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Humans; Inflammatory Bowel Diseases; Male; Middle Aged; Rats; Sequence Analysis, RNA; Trinitrobenzenesulfonic Acid | 2020 |
Discovery of a Novel Multi-Strains Probiotic Formulation with Improved Efficacy toward Intestinal Inflammation.
Topics: Animals; Bacillus subtilis; Bifidobacterium breve; Colitis; Dextran Sulfate; Disease Models, Animal; Dysbiosis; Inflammation Mediators; Intestines; Lacticaseibacillus casei; Mice; Probiotics; Streptococcus thermophilus; Trinitrobenzenesulfonic Acid | 2020 |
Mucoadhesive nanoparticles-based oral drug delivery systems enhance ameliorative effects of low molecular weight heparin on experimental colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Biomarkers; Chitosan; Colitis; Colon; Drug Delivery Systems; Drug Liberation; Gene Expression; Heparin, Low-Molecular-Weight; Kinetics; Male; Mice; Nanoparticles; Peroxidase; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2020 |
Protective Effect of Thalidomide on 2,4,6-Trinitrobenzenesulfonic Acid-Induced Experimental Colitis in Rats via the Inhibition of T Helper 17 Cells.
Topics: Animals; Colitis; Colon; Rats; Rats, Sprague-Dawley; Th17 Cells; Thalidomide; Trinitrobenzenesulfonic Acid | 2020 |
Adipose-derived mesenchymal stem cells alleviate TNBS-induced colitis in rats by influencing intestinal epithelial cell regeneration, Wnt signaling, and T cell immunity.
Topics: Adipose Tissue; Animals; Colitis; Epithelial Cells; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Regeneration; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Wnt Signaling Pathway | 2020 |
Effect of TNBS-induced colitis on enteric neuronal subpopulations in adult zebrafish.
Topics: Animals; Cholinergic Neurons; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Inflammation; Intestines; Trinitrobenzenesulfonic Acid; Zebrafish | 2020 |
In vitro and in vivo amelioration of colitis using targeted delivery system of cyclosporine a in New Zealand rabbits.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cyclosporine; Disease Models, Animal; Rabbits; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2020 |
Extracellular vesicles derived from human placental mesenchymal stem cells alleviate experimental colitis in mice by inhibiting inflammation and oxidative stress.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Epithelial Cells; Extracellular Vesicles; Female; Humans; Immunologic Factors; Inflammation; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Oxidative Stress; Placenta; Pregnancy; Trinitrobenzenesulfonic Acid | 2020 |
The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis.
Topics: Animals; Antioxidants; Colitis; Curcumin; NF-kappa B; Platelet-Derived Growth Factor; Rats; Signal Transduction; Trinitrobenzenesulfonic Acid | 2020 |
In Vitro Characterization of Gut Microbiota-Derived Commensal Strains: Selection of
Topics: Adult; Animals; Bacteroidetes; Caco-2 Cells; Colitis; Disease Models, Animal; DNA, Bacterial; Feces; Female; Gastrointestinal Microbiome; Humans; Infant, Newborn; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2020 |
Participation of the intestinal microbiota in the mechanism of beneficial effect of treatment with synbiotic Syngut on experimental colitis under stress conditions.
Topics: Adiponectin; Animals; Bifidobacterium animalis; Cold Temperature; Colitis; Colon; Cytokines; Disease Models, Animal; Gastrointestinal Microbiome; Inflammation Mediators; Inulin; Lactobacillus; Lactobacillus acidophilus; Lactobacillus plantarum; Male; Rats, Wistar; Synbiotics; Trinitrobenzenesulfonic Acid | 2020 |
Evaluation of the effect of Dahuang-Mudan decoction on TNBS-induced colitis using UPLC-QTOF/MS-based metabolomic analysis.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Mass Spectrometry; Metabolome; Metabolomics; Rats; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2021 |
Mica Can Alleviate TNBS-Induced Colitis in Mice by Reducing Angiotensin II and IL-17A and Increasing Angiotensin-Converting Enzyme 2, Angiotensin 1-7, and IL-10.
Topics: Aluminum Silicates; Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme 2; Animals; Colitis; Eating; Enzyme-Linked Immunosorbent Assay; Interleukin-10; Interleukin-17; Male; Mice; Peptide Fragments; Trinitrobenzenesulfonic Acid | 2020 |
DNA Damage-Regulated Autophagy Modulator 1 (DRAM1) Mediates Autophagy and Apoptosis of Intestinal Epithelial Cells in Inflammatory Bowel Disease.
Topics: Adolescent; Adult; Aged; Animals; Apoptosis; Autophagy; Child; Colitis; Dextran Sulfate; Epithelial Cells; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; Middle Aged; Trinitrobenzenesulfonic Acid; Up-Regulation; Young Adult | 2021 |
Mycobacterial Hsp65 antigen delivered by invasive Lactococcus lactis reduces intestinal inflammation and fibrosis in TNBS-induced chronic colitis model.
Topics: Animals; Bacterial Proteins; Chaperonin 60; Colitis; Cytokines; Disease Models, Animal; Female; Fibrosis; Immunoglobulin A; Lactococcus lactis; Mice, Inbred BALB C; Microorganisms, Genetically-Modified; Trinitrobenzenesulfonic Acid | 2020 |
Anti-inflammatory and antibacterial effects of human cathelicidin active fragment KR-12 in the mouse models of colitis: a novel potential therapy of inflammatory bowel diseases.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Antimicrobial Cationic Peptides; Cathelicidins; Colitis; Colon; Dextran Sulfate; Feces; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Peptide Fragments; Peroxidase; Trinitrobenzenesulfonic Acid | 2021 |
Cornelian Cherry Iridoid-Polyphenolic Extract Improves Mucosal Epithelial Barrier Integrity in Rat Experimental Colitis and Exerts Antimicrobial and Antiadhesive Activities
Topics: Animals; Anti-Bacterial Agents; Colitis; Colon; Escherichia coli; Humans; Inflammation; Intestinal Mucosa; Iridoids; Male; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2020 |
A polymeric diet rich in transforming growth factor beta 2 does not reduce inflammation in chronic 2,4,6-trinitrobenzene sulfonic acid colitis in pre-pubertal rats.
Topics: Animals; Colitis; Colon; Diet; Disease Models, Animal; Inflammation; Male; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta1; Transforming Growth Factor beta2; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2020 |
Rectal administration of carbon monoxide inhibits the development of intestinal inflammation and promotes intestinal wound healing via the activation of the Rho-kinase pathway in rats.
Topics: Administration, Rectal; Animals; Carbon Monoxide; Cells, Cultured; Chemokine CXCL1; Colitis; Colon; Inflammation; Intestinal Mucosa; Male; Peroxidase; Rats, Wistar; Re-Epithelialization; rho-Associated Kinases; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid; Wound Healing | 2021 |
Impact of titanium dioxide nanoparticles on intestinal community in 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced acute colitis mice and the intervention effect of vitamin E.
Topics: Animals; Colitis; Mice; Nanoparticles; Titanium; Trinitrobenzenesulfonic Acid; Vitamin E | 2021 |
Pharmacological HIF-1 stabilization promotes intestinal epithelial healing through regulation of α-integrin expression and function.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Integrin alpha Chains; Integrin alpha2; Integrin alpha6; Intestinal Mucosa; Mice, Inbred BALB C; Prolyl-Hydroxylase Inhibitors; Protein Stability; Signal Transduction; Trinitrobenzenesulfonic Acid; Wound Healing | 2021 |
Inhibition of PD-1 Protects against TNBS-Induced Colitis via Alteration of Enteric Microbiota.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Microbiome; Immune Checkpoint Inhibitors; Male; Mesalamine; Mice; Mice, Inbred BALB C; Programmed Cell Death 1 Receptor; Protective Agents; Trinitrobenzenesulfonic Acid | 2021 |
Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.
Topics: Animals; Bacterial Proteins; Channelrhodopsins; Colitis; Colon; Disease Models, Animal; Fructose; Ganglia, Spinal; Glycerol; Immunohistochemistry; Luminescent Proteins; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Confocal; Rectum; Sensory Receptor Cells; Solutions; Tissue Fixation; Trinitrobenzenesulfonic Acid; Vesicular Glutamate Transport Protein 2 | 2021 |
2,4,6-trinitrobenzenesulfonic acid-induced colitis in Rattus norgevicus: a categorization proposal.
Topics: Animals; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Male; Rats; Rats, Wistar; Retrospective Studies; Trinitrobenzenesulfonic Acid | 2021 |
Effects of Bepridil and Pimozide, Existing Medicines Capable of Blocking T-Type Ca
Topics: Analgesics; Animals; Bepridil; Calcium Channel Blockers; Calcium Channels, T-Type; Colitis; Cyclophosphamide; Cystitis; Dopamine D2 Receptor Antagonists; Female; Male; Mice; Pimozide; Trinitrobenzenesulfonic Acid; Visceral Pain | 2021 |
Canthin-6-one ameliorates TNBS-induced colitis in rats by modulating inflammation and oxidative stress. An in vivo and in silico approach.
Topics: Animals; Anti-Inflammatory Agents; Carbolines; Colitis; Computer Simulation; Fungicides, Industrial; Indole Alkaloids; Inflammation; Inflammation Mediators; Male; Oxidative Stress; Protein Structure, Secondary; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2021 |
Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling.
Topics: Animals; Colitis; Cytokines; Hypoglycemic Agents; Inflammation; Inflammatory Bowel Diseases; Janus Kinase 2; Linagliptin; Male; NF-kappa B; Oxidation-Reduction; Rats; Rats, Wistar; Signal Transduction; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid | 2021 |
Dapsone Ameliorates Colitis through TLR4/NF-kB Pathway in TNBS Induced Colitis Model in Rat.
Topics: Animals; Colitis; Colon; Dapsone; Disease Models, Animal; Humans; NF-kappa B; Rats; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2021 |
Synthesis and activity of N-(5-hydroxy-3,4,6-trimethylpyridin-2-yl)acetamide analogues as anticolitis agents via dual inhibition of TNF-α- and IL-6-induced cell adhesions.
Topics: Acetamides; Animals; Cell Adhesion; Colitis; Dose-Response Relationship, Drug; Interleukin-6; Molecular Structure; Rats; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2021 |
Inhibitor of apoptosis-stimulating p53 protein protects against inflammatory bowel disease in mice models by inhibiting the nuclear factor kappa B signaling.
Topics: Adult; Animals; Anti-Inflammatory Agents; Apoptosis; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Middle Aged; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2021 |
HG-9-91-01 Attenuates Murine Experimental Colitis by Promoting Interleukin-10 Production in Colonic Macrophages Through the SIK/CRTC3 Pathway.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Phenylurea Compounds; Protein Serine-Threonine Kinases; Pyrimidines; Transcription Factors; Trinitrobenzenesulfonic Acid | 2021 |
Mouse Models of Intestinal Fibrosis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Escherichia coli; Humans; Interleukin-10; Male; Mice; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2021 |
MiR-128-3p alleviates TNBS-induced colitis through inactivating TRAF6/NF-κB signaling pathway in rats.
Topics: Animals; Colitis; Intracellular Signaling Peptides and Proteins; MicroRNAs; NF-kappa B; Rats; Signal Transduction; Trinitrobenzenesulfonic Acid | 2021 |
Synthetic hookworm-derived peptides are potent modulators of primary human immune cell function that protect against experimental colitis in vivo.
Topics: Amino Acid Sequence; Ancylostoma; Ancylostomatoidea; Animals; Cell Proliferation; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation Mediators; Intestines; Kv1.3 Potassium Channel; Leukocytes; Magnetic Resonance Spectroscopy; Male; Mice, Inbred C57BL; Necator americanus; Peptides; Principal Component Analysis; Protein Domains; Protein Folding; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Xenopus laevis | 2021 |
Gasdermin-E-mediated pyroptosis participates in the pathogenesis of Crohn's disease by promoting intestinal inflammation.
Topics: Animals; Colitis; Crohn Disease; Epithelial Cells; Hematopoiesis; HMGB1 Protein; Humans; Inflammation; Intestinal Mucosa; Intestines; Male; Mice, Inbred C57BL; Pore Forming Cytotoxic Proteins; Pyroptosis; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2021 |
Atractylenolide III Ameliorates TNBS-Induced Intestinal Inflammation in Mice by Reducing Oxidative Stress and Regulating Intestinal Flora.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Down-Regulation; Gastrointestinal Microbiome; Interleukin-1beta; Lactones; Male; Mice; Mice, Inbred C57BL; NF-E2-Related Factor 2; Oxidative Stress; Reactive Oxygen Species; Sesquiterpenes; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2021 |
Protection by microRNA-7a-5p Antagomir Against Intestinal Mucosal Injury Related to the JNK Pathway in TNBS-Induced Experimental Colitis.
Topics: Animals; Antagomirs; Colitis; Disease Models, Animal; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; MAP Kinase Signaling System; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid | 2021 |
Curcumin improves experimentally induced colitis in mice by regulating follicular helper T cells and follicular regulatory T cells by inhibiting interleukin-21.
Topics: Animals; Colitis; Curcumin; Disease Models, Animal; Flow Cytometry; Interleukins; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; RNA, Messenger; T Follicular Helper Cells; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2021 |
Dietary salt exacerbates intestinal fibrosis in chronic TNBS colitis via fibroblasts activation.
Topics: Animals; Colitis; Diet; Disease Models, Animal; Extracellular Matrix Proteins; Fibroblasts; Fibrosis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Myofibroblasts; Rats; Salts; Trinitrobenzenesulfonic Acid | 2021 |
Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice.
Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation Mediators; Intestinal Mucosa; Macrophages; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Permeability; RAW 264.7 Cells; Receptors, G-Protein-Coupled; Sulfonamides; Tight Junction Proteins; Tight Junctions; Trinitrobenzenesulfonic Acid | 2021 |
Comparison of anti-inflammatory activities of an anthocyanin-rich fraction from Portuguese blueberries (Vaccinium corymbosum L.) and 5-aminosalicylic acid in a TNBS-induced colitis rat model.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Antioxidants; Blueberry Plants; Colitis; Colon; Cyclooxygenase 2; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mesalamine; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
A novel pyrazole-containing indolizine derivative suppresses NF-κB activation and protects against TNBS-induced colitis via a PPAR-γ-dependent pathway.
Topics: Anilides; Animals; Colitis; Female; Indolizines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; NF-kappa B; PPAR gamma; Protective Agents; Pyrazoles; Trinitrobenzenesulfonic Acid | 2017 |
IL-33-induced alternatively activated macrophage attenuates the development of TNBS-induced colitis.
Topics: Adoptive Transfer; Adult; Animals; Biopsy; Colitis; Colon; Colonoscopy; Disease Models, Animal; Female; Humans; Injections, Intraperitoneal; Interleukin-33; Macrophage Activation; Macrophages; Mice; Mice, Inbred BALB C; Middle Aged; Recombinant Proteins; Th2 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Schiff base complexes of copper and zinc as potential anti-colitic compounds.
Topics: Animals; Colitis; Copper; Edema; Hydrogen-Ion Concentration; Inflammation; Male; Mice; Molecular Structure; Organometallic Compounds; Rats; Rats, Wistar; Schiff Bases; Trinitrobenzenesulfonic Acid; Zinc | 2017 |
Protective effects of tranilast on experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; ortho-Aminobenzoates; Peroxidase; Protective Agents; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Acetylsalicylic acid-tris-hydroxymethyl-aminomethane reduces colon mucosal damage without causing gastric side effects in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Male; Mesalamine; Methylamines; Nitrates; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Constitutive ω-3 fatty acid production in fat-1 transgenic mice and docosahexaenoic acid administration to wild type mice protect against 2,4,6-trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Cadherins; Colitis; Docosahexaenoic Acids; Fatty Acids, Omega-3; Mice; Mice, Inbred C57BL; Mice, Transgenic; Trinitrobenzenesulfonic Acid | 2017 |
Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestines; Mice; Mice, Inbred BALB C; Tramadol; Trinitrobenzenesulfonic Acid | 2017 |
PRDM5 promotes the apoptosis of epithelial cells induced by IFN-γ during Crohn's disease.
Topics: Animals; Apoptosis; Caspase 3; Cell Line; Colitis; Crohn Disease; Disease Models, Animal; DNA-Binding Proteins; Epithelial Cells; Humans; Interferon-gamma; Intestinal Mucosa; Intestines; Mice; Transcription Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2017 |
Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.
Topics: Animals; Azoxymethane; Carcinogenesis; Cell Proliferation; Clostridium butyricum; Colitis; Colonic Neoplasms; Disease Models, Animal; Gene Expression Regulation, Neoplastic; Humans; In Situ Hybridization, Fluorescence; Inflammation; Interleukin-12; Mice; MicroRNAs; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Cell Proliferation; Colitis; Colonic Neoplasms; Diospyros; Gelatinases; HT29 Cells; Humans; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice, Inbred Strains; Phenols; Plant Extracts; Trinitrobenzenesulfonic Acid | 2017 |
Stimulation of autophagy prevents intestinal mucosal inflammation and ameliorates murine colitis.
Topics: Administration, Rectal; Animals; Autophagy; Betacyanins; Colitis; Female; Inflammation; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Sirolimus; Trehalose; Trinitrobenzenesulfonic Acid | 2017 |
Submucosal neurons and enteric glial cells expressing the P2X7 receptor in rat experimental colitis.
Topics: Animals; Cell Count; Colitis; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Neurons; Rats; Rats, Wistar; Receptors, Purinergic P2X7; Submucous Plexus; Trinitrobenzenesulfonic Acid | 2017 |
Inhibition of KDM4A activity as a strategy to suppress interleukin-6 production and attenuate colitis induction.
Topics: Animals; Azoles; Cells, Cultured; Colitis; Colon; Female; Fibroblasts; Furans; Histone Demethylases; Interleukin-6; Mice, Inbred BALB C; Nitro Compounds; Plant Preparations; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Critical Role of P2Y
Topics: Adenosine; Animals; Autoimmune Diseases; Cell Differentiation; Cells, Cultured; Clopidogrel; Colitis; Diabetes Mellitus, Experimental; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; Interleukin-17; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, Knockout; Purinergic P2Y Receptor Antagonists; Receptors, Purinergic P2Y12; Signal Transduction; Th17 Cells; Ticagrelor; Ticlopidine; Trinitrobenzenesulfonic Acid | 2017 |
Anti-inflammatory effects and mechanisms of vagal nerve stimulation combined with electroacupuncture in a rodent model of TNBS-induced colitis.
Topics: Animals; Colitis; Cytokines; Electroacupuncture; Gene Expression Regulation; Inflammation; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid; Vagus Nerve Stimulation | 2017 |
Chemically induced mouse models of acute and chronic intestinal inflammation.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2017 |
Estradiol Has Differential Effects on Acute Colonic Inflammation in the Presence and Absence of Estrogen Receptor β Expression.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Colonic Neoplasms; Cytokines; Estradiol; Estrogen Receptor beta; Estrogens; Female; Immunohistochemistry; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2017 |
Prophylactic and therapeutic effect of Punica granatum in trinitrobenzene sulfonic acid induced inflammation in rats.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Biomarkers; Carrier Proteins; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Fibrinogen; Gastrointestinal Agents; Glutathione; Inflammation Mediators; Lythraceae; Male; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Osthole pretreatment alleviates TNBS-induced colitis in mice via both cAMP/PKA-dependent and independent pathways.
Topics: Animals; Blotting, Western; Colitis; Coumarins; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cytokines; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Signal Transduction; Trinitrobenzenesulfonic Acid | 2017 |
Gastrointestinal inflammation by gut microbiota disturbance induces memory impairment in mice.
Topics: Animals; Cell Membrane Permeability; Colitis; Disease Models, Animal; Dysbiosis; Escherichia coli; Feces; Gastrointestinal Microbiome; Gastrointestinal Tract; Hippocampus; Humans; Inflammation; Lactobacillus johnsonii; Male; Memory Disorders; Mice; Mice, Inbred ICR; NF-kappa B; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Anti-inflammatory effect of Chang-An-Shuan on TNBS-induced experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Drugs, Chinese Herbal; Humans; Interleukin-10; Interleukin-1beta; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2017 |
Discovery and structure-activity relationship studies of 2-benzylidene-2,3-dihydro-1H-inden-1-one and benzofuran-3(2H)-one derivatives as a novel class of potential therapeutics for inflammatory bowel disease.
Topics: Animals; Benzofurans; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Female; HT29 Cells; Humans; Indenes; Inflammatory Bowel Diseases; Molecular Structure; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; U937 Cells | 2017 |
Activation of sirtuin 1 by catalpol-induced down-regulation of microRNA-132 attenuates endoplasmic reticulum stress in colitis.
Topics: Animals; Apoptosis; Caco-2 Cells; Cell Line; Colitis; Colon; Cytokines; Down-Regulation; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Humans; Iridoid Glucosides; Male; MicroRNAs; Rats, Sprague-Dawley; Reactive Oxygen Species; Sirtuin 1; Trinitrobenzenesulfonic Acid | 2017 |
Unconjugated bilirubin ameliorates the inflammation and digestive protease increase in TNBS-induced colitis.
Topics: Animals; Bilirubin; Biomarkers; Chymotrypsin; Colitis; Colon; Cytokines; Digestion; Endopeptidases; Feces; Inflammation; Inflammation Mediators; Male; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Trypsin; Weight Loss | 2017 |
Protective vascular effects of quercitrin in acute TNBS-colitis in rats: the role of nitric oxide.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cyclooxygenase 2; Female; Humans; Interleukin-1beta; Mesenteric Arteries; NADPH Oxidase 1; Nitric Oxide; Nitric Oxide Synthase; Quercetin; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Elevated fibrinogen‑like protein 2 in TNBS‑induced colitis mice: Association with Th17 and regulatory T cells.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Fibrinogen; Gene Expression Regulation; Immunohistochemistry; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice, Inbred BALB C; Spleen; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors; Trinitrobenzenesulfonic Acid | 2017 |
Bifidobacterium longum affects the methylation level of forkhead box P3 promoter in 2, 4, 6-trinitrobenzenesulphonic acid induced colitis in rats.
Topics: Animals; Bifidobacterium longum; Colitis; Disease Models, Animal; DNA Methylation; Forkhead Transcription Factors; Inflammatory Bowel Diseases; Leukocytes, Mononuclear; Probiotics; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Spleen; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2017 |
Prenylated flavonoid morusin protects against TNBS-induced colitis in rats.
Topics: Animals; Colitis; Colon; Flavonoids; Male; Matrix Metalloproteinase 2; Prenylation; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway.
Topics: Animals; Cell Line; Colitis; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Humans; Hydroquinones; Mice; Mice, Inbred BALB C; NF-E2-Related Factor 2; Reactive Oxygen Species; Signal Transduction; Smad Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2018 |
Study of the effects of spray drying in whey-starch on the probiotic capacity of Lactobacillus rhamnosus 64 in the gut of mice.
Topics: Animals; Colitis; Desiccation; Interferon-gamma; Interleukin-10; Interleukin-2; Interleukin-6; Intestine, Large; Intestine, Small; Lacticaseibacillus rhamnosus; Mice; Probiotics; Starch; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Whey | 2017 |
Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis.
Topics: Action Potentials; Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Excitatory Postsynaptic Potentials; Lumbar Vertebrae; Male; Mice, Inbred C57BL; Patch-Clamp Techniques; Physical Stimulation; Posterior Horn Cells; Rectum; Sacrum; Skin; Trinitrobenzenesulfonic Acid; Visceral Pain | 2017 |
A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Bhutan; Colitis; Colon; Corydalis; Cytokines; Male; Medicine, Traditional; Mice, Inbred C57BL; Plant Extracts; Plants, Medicinal; Trinitrobenzenesulfonic Acid | 2018 |
Total glucosides of paeony ameliorates TNBS‑induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines.
Topics: Animals; Biomarkers; Cell Differentiation; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Glucosides; Male; Paeonia; Plant Extracts; Rats; T-Lymphocytes, Regulatory; Th17 Cells; Transcription Factors; Trinitrobenzenesulfonic Acid | 2017 |
Extract from mango mistletoes Dendrophthoe pentandra ameliorates TNBS-induced colitis by regulating CD4+ T cells in mesenteric lymph nodes.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Female; Interleukin-10; Interleukin-17; Loranthaceae; Lymph Nodes; Mice, Inbred BALB C; Peroxidase; Plant Extracts; Th17 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Astragaloside II promotes intestinal epithelial repair by enhancing L-arginine uptake and activating the mTOR pathway.
Topics: Animals; Arginine; Caco-2 Cells; Cell Proliferation; Colitis; Crohn Disease; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Saponins; Signal Transduction; TOR Serine-Threonine Kinases; Treatment Outcome; Trinitrobenzenesulfonic Acid; Wound Healing | 2017 |
Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Glycogen Synthase Kinase 3 beta; Male; Mice; Peroxidase; Thiadiazoles; Trinitrobenzenesulfonic Acid | 2018 |
Interleukin-27 Is a Potential Rescue Therapy for Acute Severe Colitis Through Interleukin-10-Dependent, T-Cell-Independent Attenuation of Colonic Mucosal Innate Immune Responses.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Immunity, Innate; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-27; Intestinal Mucosa; Male; Mice; Mice, Knockout; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2017 |
Pfaffia paniculata (Brazilian ginseng) extract modulates Mapk and mucin pathways in intestinal inflammation.
Topics: Amaranthaceae; Animals; Anti-Inflammatory Agents; Colitis; Colon; Gene Expression Regulation; Glucuronidase; Male; Mitogen-Activated Protein Kinases; Mucins; Plant Extracts; Plant Roots; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2018 |
Bacteriocin biosynthesis contributes to the anti-inflammatory capacities of probiotic Lactobacillus plantarum.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Bacteriocins; Cecum; Colitis; Colon; Disease Models, Animal; DNA, Bacterial; Feces; Gastrointestinal Microbiome; Gene Deletion; Inflammatory Bowel Diseases; Interleukin-6; Lactobacillus plantarum; Mice; Probiotics; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Effect of riboflavin-producing bacteria against chemically induced colitis in mice.
Topics: Animals; Colitis; Feces; Female; Humans; Interleukin-10; Intestines; Lactobacillus; Mice; Mice, Inbred BALB C; Probiotics; Riboflavin; Streptococcus thermophilus; Trinitrobenzenesulfonic Acid | 2018 |
Inhibition of Rho kinase protects against colitis in mice by attenuating intestinal epithelial barrier dysfunction via MLC and the NF-κB pathway.
Topics: Amides; Animals; Caco-2 Cells; Colitis; Gene Expression Regulation; Humans; Intestinal Mucosa; Membrane Proteins; Mice; Myosin-Light-Chain Phosphatase; Pyridines; rho-Associated Kinases; Trinitrobenzenesulfonic Acid | 2018 |
Enteric Delivery of Regenerating Family Member 3 alpha Alters the Intestinal Microbiota and Controls Inflammation in Mice With Colitis.
Topics: Animals; Bacteria; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Fecal Microbiota Transplantation; Gastrointestinal Microbiome; Hepatocytes; Humans; Mice, Inbred C57BL; Mice, Transgenic; Microbial Viability; Oxidative Stress; Pancreatitis-Associated Proteins; Reactive Oxygen Species; Time Factors; Trinitrobenzenesulfonic Acid | 2018 |
Age, sex, and TNF associated differences in the gut microbiota of mice and their impact on acute TNBS colitis.
Topics: Age Factors; Animals; Bacteria; Colitis; Disease Models, Animal; Feces; Gastrointestinal Microbiome; Humans; Male; Mice; Mice, Knockout; RNA, Ribosomal, 16S; Sex Characteristics; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
Baicalein ameliorates TNBS-induced colitis by suppressing TLR4/MyD88 signaling cascade and NLRP3 inflammasome activation in mice.
Topics: Animals; Biomarkers; Cell Line; Cell Survival; Colitis; Cytokines; Flavanones; Humans; Inflammasomes; Inflammation Mediators; MAP Kinase Signaling System; Mice; Models, Molecular; Molecular Conformation; Myeloid Differentiation Factor 88; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Signal Transduction; Structure-Activity Relationship; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2017 |
Bifidobacteria alleviate experimentally induced colitis by upregulating indoleamine 2, 3-dioxygenase expression.
Topics: Animals; Bifidobacterium; Colitis; Colonic Diseases; Disease Models, Animal; Female; Forkhead Transcription Factors; Indoleamine-Pyrrole 2,3,-Dioxygenase; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tryptophan; Up-Regulation | 2018 |
The protective effects of magnolol on acute trinitrobenzene sulfonic acid‑induced colitis in rats.
Topics: Acute Disease; Animals; Biphenyl Compounds; Colitis; Cyclooxygenase 2; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Interleukin-17; Interleukin-6; Lignans; Male; Nitric Oxide Synthase Type II; Peroxidase; Protective Agents; Rats; Rats, Wistar; Spleen; Thymus Gland; Toll-Like Receptor 4; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2018 |
CD16+ Macrophages Mediate Fibrosis in Inflammatory Bowel Disease.
Topics: Adolescent; Adult; Animals; Cell Count; Cells, Cultured; Colitis; Colon; Colonic Neoplasms; Crohn Disease; Female; Fibrosis; Humans; Interleukin-4; Intestinal Mucosa; Lectins, C-Type; Macrophages; Male; Mannose Receptor; Mannose-Binding Lectins; Mice; Mice, Inbred BALB C; Mice, Knockout; Proto-Oncogene Proteins; Receptors, Cell Surface; Receptors, IgG; STAT6 Transcription Factor; Trinitrobenzenesulfonic Acid; Wnt Proteins; Young Adult | 2018 |
MicroRNA-425 facilitates pathogenic Th17 cell differentiation by targeting forkhead box O1 (Foxo1) and is associated with inflammatory bowel disease.
Topics: Animals; Antagomirs; Case-Control Studies; Cell Differentiation; Cell Proliferation; Colitis; Colitis, Ulcerative; Crohn Disease; Forkhead Box Protein O1; Gene Expression Regulation; Humans; Interleukin-17; Intestinal Mucosa; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; MicroRNAs; RNA, Small Interfering; Severity of Illness Index; Signal Transduction; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Aronia melanocarpa fruit juice ameliorates the symptoms of inflammatory bowel disease in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Disease Models, Animal; Fruit and Vegetable Juices; Inflammatory Bowel Diseases; Male; Photinia; Plant Extracts; Rats; Rats, Wistar; Sulfasalazine; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid | 2018 |
Anti-inflammatory effects of sinapic acid on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Coumaric Acids; Dose-Response Relationship, Drug; Female; Mice; Mice, Inbred BALB C; Random Allocation; Trinitrobenzenesulfonic Acid | 2018 |
Copaiba Oil Decreases Oxidative Stress and Inflammation But not Colon Damage in Rats with TNBS-Induced Colitis.
Topics: Animals; Colitis; Colon; Fabaceae; Inflammation; Male; Oxidative Stress; Plant Oils; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2018 |
The Plasma Kallikrein-Kininogen Pathway Is Critical in the Pathogenesis of Colitis in Mice.
Topics: Animals; Bradykinin; Colitis; Dextran Sulfate; Factor XII; Interleukin-1beta; Intestinal Mucosa; Kallikrein-Kinin System; Kininogen, High-Molecular-Weight; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Plasma Kallikrein; Prekallikrein; Receptors, Bradykinin; Trinitrobenzenesulfonic Acid | 2018 |
New probiotic strains for inflammatory bowel disease management identified by combining in vitro and in vivo approaches.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Caco-2 Cells; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Humans; Hydrogen Peroxide; Immunomodulation; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Mice; Mice, Inbred BALB C; Permeability; Probiotics; Trinitrobenzenesulfonic Acid | 2018 |
Dual expression of CXCR4 and IL-35 enhances the therapeutic effects of BMSCs on TNBS-induced colitis in rats through expansion of Tregs and suppression of Th17 cells.
Topics: Animals; Cell Movement; Cell Proliferation; Colitis; Forkhead Transcription Factors; Interleukin-12 Subunit p35; Interleukins; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Nuclear Receptor Subfamily 1, Group F, Member 3; Protective Agents; Rats, Sprague-Dawley; Receptors, CXCR4; T-Lymphocytes, Regulatory; Th17 Cells; Transfection; Trinitrobenzenesulfonic Acid; Up-Regulation | 2018 |
A Novel Topical PPARγ Agonist Induces PPARγ Activity in Ulcerative Colitis Mucosa and Prevents and Reverses Inflammation in Induced Colitis Models.
Topics: Adult; Aged; Animals; Colitis; Colitis, Ulcerative; Colon; Cytokines; Dextran Sulfate; Female; Humans; Intestinal Mucosa; Male; Mice, Inbred BALB C; Middle Aged; Perilipin-2; Peroxidase; PPAR gamma; Rosiglitazone; Trinitrobenzenesulfonic Acid | 2018 |
Protective effects of guggulsterone against colitis are associated with the suppression of TREM-1 and modulation of macrophages.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Commiphora; HT29 Cells; Humans; Inflammation; Interleukin-10; Intestinal Mucosa; Intestines; Macrophages; Mice; Pregnenediones; Signal Transduction; Toll-Like Receptor 4; Triggering Receptor Expressed on Myeloid Cells-1; Trinitrobenzenesulfonic Acid; Wound Healing | 2018 |
MicroRNA-146a-5p attenuates visceral hypersensitivity through targeting chemokine CCL8 in the spinal cord in a mouse model of colitis.
Topics: Animals; Antagomirs; Antibodies; Cells, Cultured; Chemokine CCL8; Colitis; Disease Models, Animal; Gene Expression Regulation; Humans; Hyperalgesia; Male; Mice; Mice, Inbred C57BL; MicroRNAs; Peroxidase; RNA, Small Interfering; Spinal Cord; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation; Visceral Pain | 2018 |
Pim-1 inhibitor attenuates trinitrobenzene sulphonic acid induced colitis in the mice.
Topics: Animals; Cell Differentiation; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; GATA3 Transcription Factor; Inflammatory Bowel Diseases; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Proto-Oncogene Proteins c-pim-1; RNA, Messenger; T-Lymphocytes; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2018 |
Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling.
Topics: Animals; Benzylidene Compounds; Cell Adhesion; Colitis; Colon; Cytokines; Epithelium; Gene Expression Regulation; HT29 Cells; Humans; Indenes; MAP Kinase Kinase Kinase 5; MAP Kinase Signaling System; Rats; Receptor-Interacting Protein Serine-Threonine Kinases; Trinitrobenzenesulfonic Acid | 2018 |
Norisoboldine, a natural aryl hydrocarbon receptor agonist, alleviates TNBS-induced colitis in mice, by inhibiting the activation of NLRP3 inflammasome.
Topics: Alkaloids; Animals; Colitis; Drugs, Chinese Herbal; Humans; Inflammasomes; Interleukin-1beta; Lindera; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Receptors, Aryl Hydrocarbon; Trinitrobenzenesulfonic Acid | 2018 |
Comparison of two models of inflammatory bowel disease in rats.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Oxidative Stress; Rats; Trinitrobenzenesulfonic Acid | 2018 |
Knockdown of Smad7 With a Specific Antisense Oligonucleotide Attenuates Colitis and Colitis-Driven Colonic Fibrosis in Mice.
Topics: Animals; Colitis; Collagen Type I; Colon; Crohn Disease; Disease Models, Animal; Down-Regulation; Female; Fibrosis; Gene Knockdown Techniques; Mice; Mice, Inbred BALB C; Oligonucleotides; Oligonucleotides, Antisense; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2018 |
BLT1 in dendritic cells promotes Th1/Th17 differentiation and its deficiency ameliorates TNBS-induced colitis.
Topics: Animals; Cell Differentiation; Cells, Cultured; Colitis; Colon; Cytokines; Dendritic Cells; Disease Models, Animal; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Leukotriene B4; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Leukotriene B4; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Enhanced biopharmaceutical effects of tranilast on experimental colitis model with use of self-micellizing solid dispersion technology.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Biological Availability; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Compounding; Gastrointestinal Agents; Hydrogen-Ion Concentration; Intestinal Mucosa; Male; Micelles; Neutrophil Infiltration; ortho-Aminobenzoates; Particle Size; Peroxidase; Rats, Sprague-Dawley; Solubility; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2018 |
Adoptive transfer of dendritic cells expressing CD11c reduces the immunological response associated with experimental colitis in BALB/c mice.
Topics: Adoptive Transfer; Animals; B7-2 Antigen; CD11c Antigen; Cell- and Tissue-Based Therapy; Colitis; Dendritic Cells; Humans; Immune Tolerance; Mice; Ovalbumin; Spleen; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2018 |
Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment.
Topics: Animals; Colitis; Colon; Drug Carriers; Drug Liberation; Humans; Inflammatory Bowel Diseases; Magnetics; Magnetite Nanoparticles; Male; Oleic Acid; Particle Size; Phenazines; Porosity; Rats, Wistar; Silicon Dioxide; Surface Properties; Trinitrobenzenesulfonic Acid | 2018 |
[Protective role of green tea polyphenols in intestinal mucosal barrier function of mice with colitis induced by TNBS through inhibiting JAK2/STAT3 pathway].
Topics: Animals; Camellia sinensis; Claudin-1; Colitis; Humans; Intestinal Mucosa; Janus Kinase 2; Male; Mice; Mice, Inbred BALB C; Plant Extracts; Polyphenols; Signal Transduction; STAT3 Transcription Factor; Tea; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Reversing Ongoing Chronic Intestinal Inflammation and Fibrosis by Sustained Block of IL-12 and IL-23 Using a Vaccine in Mice.
Topics: Animals; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Fibrosis; Interleukin-12 Subunit p40; Interleukin-23; Intestines; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Vaccines, Subunit | 2018 |
Cytokine IL9 Triggers the Pathogenesis of Inflammatory Bowel Disease Through the miR21-CLDN8 Pathway.
Topics: Animals; Caco-2 Cells; Case-Control Studies; Claudins; Colitis; Crohn Disease; Follow-Up Studies; Humans; Interleukin-9; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Trinitrobenzenesulfonic Acid | 2018 |
Treatment with Obestatin-A Ghrelin Gene-Encoded Peptide-Reduces the Severity of Experimental Colitis Evoked by Trinitrobenzene Sulfonic Acid.
Topics: Animals; Colitis; Disease Models, Animal; Ghrelin; Rats; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2018 |
Portulacaoleraceal extract alleviates trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Body Weight; Colitis; Colon; Male; Malondialdehyde; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Plant Extracts; Portulacaceae; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2018 |
Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
Topics: Animals; Apoptosis; Bone Marrow Cells; Calcium-Binding Proteins; Cell Differentiation; Cell Proliferation; Colitis; Cytokines; Extracellular Matrix Proteins; Immunomodulation; Inflammation Mediators; Lymphocyte Activation; Matrix Gla Protein; Mesenchymal Stem Cells; Mice, Inbred C57BL; Peritoneal Lavage; Protein Processing, Post-Translational; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Vitamin K | 2018 |
[Effects of Pim-1 inhibitor on mouse model of inflammatory bowel disease induced by TNBS].
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Colon; Ethanol; Forkhead Transcription Factors; GATA3 Transcription Factor; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Nuclear Receptor Subfamily 1, Group F, Member 3; Prednisolone; Proto-Oncogene Proteins c-pim-1; Random Allocation; T-Box Domain Proteins; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2018 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; HT29 Cells; Humans; Indans; Inflammatory Bowel Diseases; Molecular Structure; Monocytes; Pyridines; Rats; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Intake of Protein Hydrolysates and Phenolic Fractions Isolated from Flaxseed Ameliorates TNBS-Induced Colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Female; Flax; Inflammation Mediators; Mice; Mice, Inbred BALB C; Nitric Oxide; Phenols; Protein Hydrolysates; RAW 264.7 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Colonic migrating motor complexes are inhibited in acute tri-nitro benzene sulphonic acid colitis.
Topics: Acute Disease; Animals; Blood Vessels; Body Weight; CD11b Antigen; Colitis; Colon; Immunity, Innate; Interleukin-1beta; Intestinal Mucosa; Male; Mice, Inbred C57BL; Myoelectric Complex, Migrating; Neurons; Trinitrobenzenesulfonic Acid | 2018 |
Comparative Analysis between the In Vivo Biodistribution and Therapeutic Efficacy of Adipose-Derived Mesenchymal Stromal Cells Administered Intraperitoneally in Experimental Colitis.
Topics: Adipose Tissue; Animals; Cell Communication; Cell Differentiation; Cell Movement; Colitis; Disease Models, Animal; Genes, Reporter; Humans; Injections, Intraperitoneal; Intestinal Mucosa; Intestines; Liver; Luciferases; Luminescent Measurements; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred C57BL; Spleen; Trinitrobenzenesulfonic Acid | 2018 |
Targeting eotaxin-1 and CCR3 receptor alleviates enteric neuropathy and colonic dysfunction in TNBS-induced colitis in guinea pigs.
Topics: Animals; Chemokine CCL11; Colitis; Eosinophils; Female; Guinea Pigs; Male; Myenteric Plexus; Receptors, CCR3; Trinitrobenzenesulfonic Acid | 2018 |
Farrerol Ameliorates TNBS-Induced Colonic Inflammation by Inhibiting ERK1/2, JNK1/2, and NF-κB Signaling Pathway.
Topics: Animals; Chromones; Colitis; Cytokines; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 8; Mitogen-Activated Protein Kinase 9; Mitogen-Activated Protein Kinases; NF-kappa B; Phytotherapy; RAW 264.7 Cells; Rhododendron; Signal Transduction; Trinitrobenzenesulfonic Acid | 2018 |
Treatment with Trichilia catigua ethyl-acetate fraction improves healing and reduces oxidative stress in TNBS-induced colitis in rats.
Topics: Acetates; Administration, Oral; Animals; Biomarkers; Body Weight; Colitis; Colon; Inflammation; Male; Meliaceae; Myenteric Plexus; Neurons; Oxidative Stress; Peroxidase; Plant Extracts; Rats, Wistar; Trinitrobenzenesulfonic Acid; Wound Healing | 2018 |
Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice.
Topics: Animals; Bacterial Load; Cattle; Colitis; Colostrum; Cytokines; Gastrointestinal Microbiome; Male; Mice; Protective Agents; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2018 |
Melatonin ameliorates TNBS-induced colitis in rats through the melatonin receptors: involvement of TLR4/MyD88/NF-κB signalling pathway.
Topics: Animals; Colitis; Colon; Down-Regulation; Intestinal Mucosa; Male; Melatonin; Myeloid Differentiation Factor 88; NF-kappa B; Rats; Rats, Wistar; Receptors, Melatonin; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Up-Regulation | 2019 |
Effect of hesperetin on inflammatory and oxidative status in trinitrobenzene sulfonic acid-induced experimental colitis model.
Topics: Animals; Antioxidants; Colitis; Enzyme-Linked Immunosorbent Assay; Hesperidin; Immunohistochemistry; In Situ Nick-End Labeling; Interleukin-6; Lipid Peroxidation; Male; Malondialdehyde; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Brusatol ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced experimental colitis in rats: Involvement of NF-κB pathway and NLRP3 inflammasome.
Topics: Animals; Cell Survival; Colitis; Colon; Cytokines; Male; Mice; NF-E2-Related Factor 2; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Oxidative Stress; Quassins; Rats; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Trinitrobenzenesulfonic Acid | 2018 |
FKBP11 protects intestinal epithelial cells against inflammation‑induced apoptosis via the JNK‑caspase pathway in Crohn's disease.
Topics: Animals; Apoptosis; Caspases; Colitis; Crohn Disease; Endoplasmic Reticulum Stress; Epithelial Cells; Gene Expression Regulation; Humans; Inflammation; Interferon-gamma; Intestinal Mucosa; MAP Kinase Kinase 4; Mice; RNA, Small Interfering; Signal Transduction; Tacrolimus Binding Proteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2018 |
Lysophosphatidylinositols in inflammation and macrophage activation: Altered levels and anti-inflammatory effects.
Topics: Animals; Cell Line; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation; Group IV Phospholipases A2; Lipopolysaccharides; Liver; Lysophospholipids; Macrophages; Male; Mice; Monoacylglycerol Lipases; Receptors, G-Protein-Coupled; Spleen; Tissue Distribution; Trinitrobenzenesulfonic Acid | 2018 |
MiR-155 inhibition ameliorates 2, 4, 6-Trinitrobenzenesulfonic acid (TNBS)-induced experimental colitis in rat via influencing the differentiation of Th17 cells by Jarid2.
Topics: Animals; Cell Differentiation; Colitis; Male; MicroRNAs; Polycomb Repressive Complex 2; Rats; Rats, Sprague-Dawley; Receptor, Notch1; Th17 Cells; Trinitrobenzenesulfonic Acid | 2018 |
Daikenchuto (Da-Jian-Zhong-Tang) ameliorates intestinal fibrosis by activating myofibroblast transient receptor potential ankyrin 1 channel.
Topics: Adult; Animals; Cell Line; Chronic Disease; Colitis; Colon; Crohn Disease; Disease Models, Animal; Fibrosis; Humans; Male; Mice; Mice, Knockout; Middle Aged; Myofibroblasts; Panax; Plant Extracts; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; Zanthoxylum; Zingiberaceae | 2018 |
NOX1-derived ROS drive the expression of Lipocalin-2 in colonic epithelial cells in inflammatory conditions.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytochrome b Group; Cytokines; Gene Expression Regulation; Humans; Immunity, Innate; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Lipocalin-2; Mice; Mice, Knockout; NADPH Oxidase 1; NADPH Oxidases; p38 Mitogen-Activated Protein Kinases; Reactive Oxygen Species; RNA, Small Interfering; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Non-toxigenic Bacteroides fragilis (NTBF) administration reduces bacteria-driven chronic colitis and tumor development independent of polysaccharide A.
Topics: Adenomatous Polyposis Coli Protein; Animals; Bacteroides fragilis; Carcinogenesis; Cells, Cultured; Colitis; Colorectal Neoplasms; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction.
Topics: Afferent Pathways; Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Guanylyl Cyclase C Agonists; Humans; Hyperalgesia; Irritable Bowel Syndrome; Male; Mice; Neuronal Plasticity; Nociception; Peptides; Treatment Outcome; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urinary Bladder, Overactive | 2018 |
Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways.
Topics: Acute Disease; Animals; Benzopyrans; CARD Signaling Adaptor Proteins; Colitis; Disease Models, Animal; Inflammasomes; Inflammation; Inflammation Mediators; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Protective Agents; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2019 |
Beneficial role of Terminalia arjuna hydro-alcoholic extract in colitis and its possible mechanism.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Feces; Female; Gene Expression; Phytotherapy; Plant Bark; Plant Extracts; Rats, Wistar; Terminalia; Trinitrobenzenesulfonic Acid; Zinc | 2019 |
Oenothera rosea L´Hér. ex Ait attenuates acute colonic inflammation in TNBS-induced colitis model in rats: in vivo and in silico myeloperoxidase role.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Down-Regulation; Female; Inflammation; Interleukin-1beta; Intestinal Mucosa; Nitric Oxide; Oenothera; Peroxidase; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2018 |
Immunohistochemical examination of anti-inflammatory and anti-apoptotic effects of hesperetin on trinitrobenzene sulfonic acid induced colitis in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Colitis; Gene Expression Regulation; Hesperidin; Immunohistochemistry; Inflammation; Leukocyte Common Antigens; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Ginsenoside Rb1 promotes intestinal epithelial wound healing through extracellular signal-regulated kinase and Rho signaling.
Topics: Animals; Cell Line; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Extracellular Signal-Regulated MAP Kinases; Ginsenosides; Intestinal Mucosa; Male; Panax; Plant Extracts; Rats, Wistar; rho GTP-Binding Proteins; Signal Transduction; Trinitrobenzenesulfonic Acid; Wound Healing; Zanthoxylum; Zingiberaceae | 2019 |
Effect of Trichinella spiralis intervention on TNBS-induced experimental colitis in mice.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Humans; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th2 Cells; Therapy with Helminths; Trichinella spiralis; Trichinellosis; Trinitrobenzenesulfonic Acid | 2019 |
Effect of recombinant Trichinella spiralis cysteine proteinase inhibitor on TNBS-induced experimental inflammatory bowel disease in mice.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cysteine Proteinase Inhibitors; Disease Models, Animal; Humans; Immunomodulation; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th1 Cells; Th1-Th2 Balance; Th2 Cells; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2019 |
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation.
Topics: Actins; Animals; Antibodies, Neutralizing; Case-Control Studies; Cells, Cultured; Colitis; Colitis, Ulcerative; Collagen Type VI; Colon; Crohn Disease; Dextran Sulfate; Fibroblasts; Fibrosis; Gene Expression; Gene Expression Profiling; Humans; Interleukin-1; Intestinal Mucosa; Intestine, Small; Ligands; Mice; Mice, Knockout; Receptors, Interleukin-1; Signal Transduction; Transcriptome; Trinitrobenzenesulfonic Acid | 2019 |
[Rosiglitazone ameliorates TNBS-induced colitis in mice by inhibiting inflammation of the mesenteric adipose tissues].
Topics: Adipose Tissue; Animals; Colitis; Cytokines; Inflammation; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Rats; Rosiglitazone; Trinitrobenzenesulfonic Acid | 2018 |
Fermented Red Ginseng Alleviates Cyclophosphamide-Induced Immunosuppression and 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Regulating Macrophage Activation and T Cell Differentiation.
Topics: Adjuvants, Immunologic; Administration, Oral; Animals; Cell Differentiation; Cells, Cultured; Colitis; Cyclophosphamide; Fermentation; Immunosuppressive Agents; Interferon-gamma; Interleukin-17; Interleukin-6; Macrophage Activation; Male; Mice, Inbred BALB C; Panax; Phytotherapy; Plant Extracts; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2018 |
Combination therapy of mesenchymal stromal cells and sulfasalazine attenuates trinitrobenzene sulfonic acid induced colitis in the rat: The S1P pathway.
Topics: Animals; bcl-2-Associated X Protein; Colitis; Colon; Gastrointestinal Agents; Gene Expression Regulation; Humans; Macrophages; Male; Mesenchymal Stem Cell Transplantation; Neoplasm Proteins; NF-kappa B; Nucleocytoplasmic Transport Proteins; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Serine Endopeptidases; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2019 |
Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function.
Topics: Animals; Colitis; Colon; Dioscorea; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Inulin; Male; Plant Extracts; Polysaccharides; Prebiotics; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2019 |
Total Glycosides of Peony Protects Against Inflammatory Bowel Disease by Regulating IL-23/IL-17 Axis and Th17/Treg Balance.
Topics: Animals; Colitis; Disease Models, Animal; Glycosides; Inflammatory Bowel Diseases; Interleukin-17; Interleukin-23; Male; Mice, Inbred BALB C; Paeonia; Phytotherapy; Specific Pathogen-Free Organisms; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
The recruitment of extra-intestinal cells to the injured mucosa promotes healing in radiation enteritis and chemical colitis in a mouse parabiosis model.
Topics: Animals; Antigens, Ly; Bone Marrow Cells; Cell Movement; Colitis; Disease Models, Animal; Enteritis; Female; Humans; Intestinal Mucosa; Intestine, Small; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Parabiosis; Paracrine Communication; Radiation Injuries, Experimental; Receptors, CXCR4; Trinitrobenzenesulfonic Acid; Wound Healing | 2019 |
Extracellular vesicles containing miR-146a attenuate experimental colitis by targeting TRAF6 and IRAK1.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Extracellular Vesicles; Interleukin-1 Receptor-Associated Kinases; Male; Mesenchymal Stem Cells; MicroRNAs; Rats, Sprague-Dawley; TNF Receptor-Associated Factor 6; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2019 |
High activity of the endogenous opioid system and acute but not chronic stress influence experimental colitis development in mice.
Topics: Analgesia; Animals; Colitis; Disease Models, Animal; Male; Mice; Narcotic Antagonists; Peroxidase; Stress, Psychological; Trinitrobenzenesulfonic Acid | 2018 |
Divergent Effectiveness of Multispecies Probiotic Preparations on Intestinal Microbiota Structure Depends on Metabolic Properties.
Topics: Animals; Bacteria; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Fatty Acids, Volatile; Gastrointestinal Microbiome; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Macrophages; Male; Mice, Inbred BALB C; Probiotics; Species Specificity; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2019 |
Acute Colitis Drives Tolerance by Persistently Altering the Epithelial Barrier and Innate and Adaptive Immunity.
Topics: Acute Disease; Adaptive Immunity; Animals; Cell Membrane Permeability; Colitis; Disease Models, Animal; Epithelium; Immune Tolerance; Immunity, Innate; Inflammation; Male; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 2019 |
Faecalibacterium prausnitzii produces butyrate to decrease c-Myc-related metabolism and Th17 differentiation by inhibiting histone deacetylase 3.
Topics: Animals; Anti-Inflammatory Agents; Butyrates; Cell Differentiation; Colitis; Faecalibacterium prausnitzii; Histone Deacetylases; Male; Mice; Mice, Inbred C57BL; Proto-Oncogene Proteins c-myc; Rats; Rats, Sprague-Dawley; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
Efficacy of budesonide-loaded mesoporous silica microparticles capped with a bulky azo derivative in rats with TNBS-induced colitis.
Topics: Animals; Azo Compounds; Budesonide; Colitis; Drug Delivery Systems; Male; Rats; Silicon Dioxide; Trinitrobenzenesulfonic Acid | 2019 |
Dendritic cells treated by Trichinella spiralis muscle larval excretory/secretory products alleviate TNBS-induced colitis in mice.
Topics: Animals; Antigens, Helminth; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Helminth Proteins; Humans; Immunotherapy; Inflammatory Bowel Diseases; Lymphocyte Activation; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th2 Cells; Therapy with Helminths; Trichinella spiralis; Trinitrobenzenesulfonic Acid | 2019 |
Electroacupuncture Alleviated Referral Hindpaw Hyperalgesia via Suppressing Spinal Long-Term Potentiation (LTP) in TNBS-Induced Colitis Rats.
Topics: Animals; Colitis; Disease Models, Animal; Electroacupuncture; Hindlimb; Hyperalgesia; Long-Term Potentiation; Male; Nociception; Pain Threshold; Rats, Sprague-Dawley; Spinal Cord; Trinitrobenzenesulfonic Acid | 2019 |
DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SELENBP1 Partially by p65NF-
Topics: Animals; Base Sequence; Colitis; Crohn Disease; DNA Methylation; Down-Regulation; HT29 Cells; Humans; Hydrogen Peroxide; Mice; MicroRNAs; Oxidative Stress; Selenium-Binding Proteins; Signal Transduction; Trinitrobenzenesulfonic Acid | 2019 |
A Manganese-Superoxide Dismutase From Thermus thermophilus HB27 Suppresses Inflammatory Responses and Alleviates Experimentally Induced Colitis.
Topics: Animals; Colitis; Dextran Sulfate; Inflammation; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; Oxidative Stress; Reactive Oxygen Species; Superoxide Dismutase; Thermus thermophilus; Trinitrobenzenesulfonic Acid; Zebrafish | 2019 |
Pharmacological mechanism of Sishen Wan
Topics: Animals; Anti-Inflammatory Agents; beta Catenin; Chronic Disease; Colitis; Colon; Cytokines; Drugs, Chinese Herbal; Male; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Wnt Signaling Pathway; Wnt3A Protein | 2019 |
Urine Proteome Changes in a TNBS-Induced Colitis Rat Model.
Topics: Animals; Colitis; Disease Models, Animal; Male; Proteomics; Rats; Rats, Wistar; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid | 2019 |
Effect of Forced Physical Activity on the Severity of Experimental Colitis in Normal Weight and Obese Mice. Involvement of Oxidative Stress and Proinflammatory Biomarkers.
Topics: Animals; Biomarkers; Colitis; Diet, High-Fat; Gene Expression Regulation; Glutathione; Inflammation; Intestinal Mucosa; Lipid Peroxidation; Male; Mice; Mice, Inbred C57BL; Oxidative Stress; Physical Conditioning, Animal; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2019 |
Potential Mechanisms of 3, 4-Oxo-Isopropylidene-Shikimic Acid in Ameliorating 2, 4, 6-Trinitrobenzenesulfonic Acid-Induced Colitis in Rats.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Molecular Conformation; Rats; Rats, Sprague-Dawley; Shikimic Acid; Trinitrobenzenesulfonic Acid | 2019 |
Roseburia intestinalis supernatant ameliorates colitis induced in mice by regulating the immune response.
Topics: Animals; Clostridiales; Colitis; Colon; Culture Media, Conditioned; Dextran Sulfate; Fatty Acids, Volatile; Gene Expression Regulation; Immunity, Innate; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred C57BL; Primary Cell Culture; RAW 264.7 Cells; Signal Transduction; STAT3 Transcription Factor; Th17 Cells; Trinitrobenzenesulfonic Acid | 2019 |
Linear growth failure induced by systemic inflammation inhibiting IGF-1/IGFBP axis in rats with asymptomatic colitis.
Topics: Analysis of Variance; Animals; Colitis; Growth; Hepatocytes; Inflammation; Insulin-Like Growth Factor Binding Protein 2; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Interleukin-6; Leukocyte L1 Antigen Complex; Liver; Malnutrition; NF-kappa B; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
EZH2 Regulates Intestinal Inflammation and Necroptosis Through the JNK Signaling Pathway in Intestinal Epithelial Cells.
Topics: Animals; Caco-2 Cells; Chemokine CCL20; Chemokine CCL5; Colitis; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gene Knockdown Techniques; Humans; In Vitro Techniques; Inflammation; Inflammatory Bowel Diseases; Interleukin-17; Interleukin-8; Intestinal Mucosa; JNK Mitogen-Activated Protein Kinases; MAP Kinase Signaling System; Mice; Necroptosis; Nuclear Pore Complex Proteins; Phosphoproteins; Proto-Oncogene Proteins c-jun; Real-Time Polymerase Chain Reaction; Receptor-Interacting Protein Serine-Threonine Kinases; RNA-Binding Proteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2019 |
Dihydroartemisinin Regulates the Th/Treg Balance by Inducing Activated CD4+ T cell Apoptosis via Heme Oxygenase-1 Induction in Mouse Models of Inflammatory Bowel Disease.
Topics: Animals; Apoptosis; Artemisinins; Colitis; Disease Models, Animal; Enzyme Induction; Heme Oxygenase-1; Inflammatory Bowel Diseases; Lymphocyte Activation; Lymphocyte Subsets; Mice; Oxazolone; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2019 |
Grape peel powder promotes intestinal barrier homeostasis in acute TNBS-colitis: A major role for dietary fiber and fiber-bound polyphenols.
Topics: Acute Disease; Animals; Chromatography, High Pressure Liquid; Colitis; Colon; Dietary Fiber; Disease Models, Animal; Fatty Acids, Volatile; Feces; Homeostasis; Hydrogen-Ion Concentration; Male; Permeability; Polyphenols; Powders; Rats; Rats, Wistar; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Vitis | 2019 |
Sacral nerve stimulation improves colonic inflammation mediated by autonomic-inflammatory cytokine mechanism in rats.
Topics: Animals; Autonomic Nervous System; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Electric Stimulation Therapy; Inflammation; Inflammatory Bowel Diseases; Lumbosacral Plexus; Rats; Trinitrobenzenesulfonic Acid; Vagus Nerve Stimulation | 2019 |
[Protective effect of procyanidin B2 on intestinal barrier and against enteritis in a mouse model of trinitrobenzene sulphonic acid-induced colitis].
Topics: Animals; Biflavonoids; Catechin; Colitis; Colon; Enteritis; Intestinal Mucosa; Male; Mice; Phosphatidylinositol 3-Kinases; Proanthocyanidins; Trinitrobenzenesulfonic Acid | 2019 |
Therapeutic effectiveness of rectally administered fish oil and mesalazine in trinitrobenzenesulfonic acid-induced colitis.
Topics: Animals; Colitis; Cytokines; Fish Oils; Intestinal Mucosa; Mesalamine; Oxidative Stress; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2019 |
Supercritical Fluid Extract of
Topics: Angelica sinensis; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Biopsy; Cell Survival; Chromatography, Supercritical Fluid; Colitis; Cytokines; Disease Models, Animal; Gas Chromatography-Mass Spectrometry; Inflammation Mediators; Lipopolysaccharides; Lymphocytes; Mice; Nitric Oxide; Plant Extracts; Rats; RAW 264.7 Cells; Spleen; Trinitrobenzenesulfonic Acid; Zingiber officinale | 2019 |
Epicutaneous immunization with protein antigen TNP-Ig alleviates TNBS-induced colitis in mice.
Topics: Administration, Cutaneous; Animals; Biomarkers; Cells, Cultured; Colitis; Colon; Desensitization, Immunologic; Disease Models, Animal; Female; Immunoglobulins; Inflammation Mediators; Interferon-gamma; Interleukin-10; Interleukin-17; Mice; Neutrophils; Peroxidase; Severity of Illness Index; Skin; Spleen; Time Factors; Transdermal Patch; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2012 |
Probiotics increase T regulatory cells and reduce severity of experimental colitis in mice.
Topics: Animals; Biomarkers; CD4 Lymphocyte Count; Colitis; Colon; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Inflammation Mediators; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Probiotics; Severity of Illness Index; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
Ameliorative effects of 3,4-oxo-isopropylidene-shikimic acid on experimental colitis and their mechanisms in rats.
Topics: Animals; Antioxidants; Cells, Cultured; Colitis; Colon; Cyclooxygenase 2; Dinoprostone; Glutathione Peroxidase; Male; Malondialdehyde; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Shikimic Acid; Trinitrobenzenesulfonic Acid | 2013 |
Novel effects of ectoine, a bacteria-derived natural tetrahydropyrimidine, in experimental colitis.
Topics: Amino Acids, Diamino; Animals; Body Weight; Colitis; Colon; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Glutathione; Intercellular Adhesion Molecule-1; Interleukin-1beta; Leukotriene B4; Male; Malondialdehyde; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chronic Disease; Colitis; Colon; Cytokine TWEAK; Disease Models, Animal; Female; Fibroblasts; Fibrosis; Humans; Immunoglobulins; Interleukin-13; Mice; Mice, Inbred BALB C; Mice, Knockout; Organ Culture Techniques; Receptors, Cytokine; Receptors, Tumor Necrosis Factor; Th2 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factors; TWEAK Receptor | 2013 |
Sirolimus ameliorates inflammatory responses by switching the regulatory T/T helper type 17 profile in murine colitis.
Topics: Animals; Anti-Inflammatory Agents; CD4 Lymphocyte Count; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunosuppressive Agents; Inflammation Mediators; Injections, Intraperitoneal; Interleukin-17; Interleukin-6; Lymph Nodes; Male; Mice; Mice, Inbred BALB C; Phenotype; Sirolimus; Th17 Cells; Time Factors; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Intussusceptive remodeling of vascular branch angles in chemically-induced murine colitis.
Topics: Animals; Blood Vessels; Colitis; Colon; Corrosion Casting; Dextran Sulfate; Disease Models, Animal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Microscopy, Electron, Scanning; Neovascularization, Pathologic; Trinitrobenzenesulfonic Acid | 2013 |
The anti-inflammatory potential of phenolic compounds in grape juice concentrate (G8000™) on 2,4,6-trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Beverages; Colitis; Colon; Dose-Response Relationship, Drug; Male; Phenols; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Vitis | 2013 |
Chrysin ameliorates chemically induced colitis in the mouse through modulation of a PXR/NF-κB signaling pathway.
Topics: Animals; Blotting, Western; Colitis; Dextran Sulfate; Female; Flavonoids; Fluorescent Antibody Technique; Gene Silencing; Genes, Reporter; Humans; Interleukin-6; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxidase; Pregnane X Receptor; Receptors, Steroid; RNA; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2013 |
Alteration of neuromuscular transmissions in the hamster colon following the resolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Cricetinae; Electric Stimulation; Male; Mesocricetus; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Oxadiazoles; Peristalsis; Quinoxalines; Receptors, Tachykinin; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2013 |
Dexmedetomidine ameliorates TNBS-induced colitis by inducing immunomodulator effect.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cells, Cultured; Colitis; Cytokines; Dexmedetomidine; Disease Models, Animal; Dose-Response Relationship, Drug; Immune System; Immunomodulation; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Spleen; Th17 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2013 |
TRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcium Signaling; Chemokines; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation; Inflammation Mediators; Ion Channel Gating; Mice; Mice, Knockout; Pyrimidinones; Trinitrobenzenesulfonic Acid; TRPM Cation Channels; TRPV Cation Channels | 2013 |
Brazilian propolis ameliorates trinitrobenzene sulfonic acid-induced colitis in mice by inhibiting Th1 differentiation.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Haptens; Interferon-gamma; Male; Mice; Mice, Inbred BALB C; Propolis; Th1 Cells; Trinitrobenzenesulfonic Acid | 2013 |
Enhanced excitability of guinea pig ileum myenteric AH neurons during and following recovery from chemical colitis.
Topics: Animals; Colitis; Excitatory Postsynaptic Potentials; Gastrointestinal Motility; Guinea Pigs; Ileum; Motor Neurons; Recovery of Function; Trinitrobenzenesulfonic Acid | 2013 |
The stimulatory adenosine receptor ADORA2B regulates serotonin (5-HT) synthesis and release in oxygen-depleted EC cells in inflammatory bowel disease.
Topics: Adenosine; Adult; Aged; Animals; Cell Hypoxia; Colitis; Disease Models, Animal; Enterochromaffin Cells; Female; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Middle Aged; Oxygen; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2B; Response Elements; RNA, Messenger; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2013 |
Faecalibacterium prausnitzii upregulates regulatory T cells and anti-inflammatory cytokines in treating TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Biopsy, Needle; Colitis; Cytokines; Disease Models, Animal; Humans; Immunohistochemistry; Intestinal Mucosa; Male; Probiotics; Random Allocation; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Up-Regulation | 2013 |
PPAR-γ and tollip are associated with toll-like receptors in colitis rats.
Topics: Animals; Colitis; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; PPAR gamma; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Toll-Like Receptor 2; Toll-Like Receptor 4; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2013 |
N-(3', 4'-dimethoxycinnamonyl) anthranilic acid alleviated experimental colitis by inhibiting autoimmune response and inducing CD4+ CD25+ regulatory T cells production.
Topics: Adult; Animals; Autoimmunity; CD4 Antigens; Cells, Cultured; Colitis; Crohn Disease; Cytokines; Female; Humans; Interleukin-2 Receptor alpha Subunit; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mucous Membrane; ortho-Aminobenzoates; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2013 |
Short-chain fatty acids activate GPR41 and GPR43 on intestinal epithelial cells to promote inflammatory responses in mice.
Topics: Animals; Citrobacter rodentium; Colitis; Disease Models, Animal; Enterobacteriaceae Infections; Epithelial Cells; Ethanol; Fatty Acids, Volatile; Intestinal Mucosa; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, G-Protein-Coupled; Trinitrobenzenesulfonic Acid | 2013 |
Serum calprotectin levels correlate with biochemical and histological markers of disease activity in TNBS colitis.
Topics: Animals; Biomarkers; Colitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Feces; Humans; Inflammatory Bowel Diseases; Interleukin-6; Leukocyte L1 Antigen Complex; Male; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss | 2013 |
Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Endotoxemia; Female; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunity, Innate; Immunity, Mucosal; Intestinal Mucosa; Mice; Permeability; Piperazines; Prolyl Hydroxylases; Prolyl-Hydroxylase Inhibitors; Pyridones; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Oxidative stress disrupts purinergic neuromuscular transmission in the inflamed colon.
Topics: Animals; Colitis; Cyclic N-Oxides; Dextran Sulfate; Female; Free Radical Scavengers; Gastrointestinal Motility; Guinea Pigs; In Vitro Techniques; Male; Mice; Mice, Inbred BALB C; Muscle, Smooth; Oxidative Stress; Purines; Spin Labels; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2013 |
Lactobacillus brevis G-101 ameliorates colitis in mice by inhibiting NF-κB, MAPK and AKT pathways and by polarizing M1 macrophages to M2-like macrophages.
Topics: Animals; Colitis; Colon; Cytokines; Interleukin-10; Levilactobacillus brevis; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinases; NF-kappa B; Proto-Oncogene Proteins c-akt; Trinitrobenzenesulfonic Acid | 2013 |
Post-translational loss of renal TRPV5 calcium channel expression, Ca(2+) wasting, and bone loss in experimental colitis.
Topics: Animals; Biomarkers; Bone Density; Calcium; Calcium Channels; CD4-Positive T-Lymphocytes; Colitis; Glucuronidase; Interferon-gamma; Kidney; Klotho Proteins; Mice; Mice, Transgenic; Protein Processing, Post-Translational; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Tomography, X-Ray Computed; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Tumor Necrosis Factor-alpha | 2013 |
Gastrointestinal pain: unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation.
Topics: Acetylcholine; Acetylglucosamine; Adenocarcinoma; Animals; Cell Differentiation; Cell Line, Tumor; Colitis; Colon; Colorectal Neoplasms; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Female; Gastrointestinal Diseases; Gene Expression Regulation, Neoplastic; Guanylate Cyclase; Humans; Hyperalgesia; Intestinal Mucosa; Male; Mast Cells; Morphine; Multidrug Resistance-Associated Proteins; Natriuretic Peptides; Organic Anion Transporters, Sodium-Independent; Peroxidase; Rats; Rats, Sprague-Dawley; Rats, Wistar; Restraint, Physical; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid; Visceral Pain | 2013 |
Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine.
Topics: Animals; Brain; Colitis; Cytokines; Down-Regulation; Enzyme Inhibitors; Gastrointestinal Motility; Gene Expression; Intestinal Mucosa; Male; Mice, Inbred C57BL; Myenteric Plexus; Neurons; Phenylalanine; Pyrimidines; Serotonin; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tryptophan Hydroxylase | 2014 |
Paraoxonase-1 suppresses experimental colitis via the inhibition of IFN-γ production from CD4 T cells.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Aryldialkylphosphatase; CD4-Positive T-Lymphocytes; Cell Differentiation; Cell Line; CHO Cells; Colitis; Colon; Cricetinae; Crohn Disease; Female; Humans; Interferon-gamma; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; NF-kappa B; Th1 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Evaluation of the usefulness of colonoscopy with mucosal biopsies in the follow-up of TNBS-induced colitis in rats.
Topics: Animals; Biopsy; Colitis; Colon; Colonoscopy; Disease Models, Animal; Intestinal Mucosa; Male; Rats; Trinitrobenzenesulfonic Acid | 2013 |
Recovery from TNBS-induced colitis leads to the resistance to recurrent colitis and an increased ratio of FOXP3 to CD3 mRNA.
Topics: Acute Disease; Animals; CD3 Complex; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Forkhead Transcription Factors; Gene Expression; Immune Tolerance; Mice; Mice, Inbred BALB C; Recurrence; RNA, Messenger; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2013 |
Changes in the expression of smooth muscle contractile proteins in TNBS- and DSS-induced colitis in mice.
Topics: Acetylcholine; Actins; Animals; Calcium-Binding Proteins; Calmodulin-Binding Proteins; Calponins; Colitis; Contractile Proteins; Cytoskeletal Proteins; Dextran Sulfate; Inflammation; Male; Mice; Mice, Inbred C57BL; Microfilament Proteins; Muscle Contraction; Muscle Proteins; Muscle, Smooth; Trinitrobenzenesulfonic Acid; Tropomyosin | 2013 |
Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis.
Topics: Animals; Bacterial Translocation; Colitis; Colon; Disease Models, Animal; Endotoxins; Glucagon-Like Peptide 2; Male; Peroxidase; Random Allocation; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Interaction of Lactobacillus fermentum BGHI14 with rat colonic mucosa: implications for colitis induction.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Host-Pathogen Interactions; Intestinal Mucosa; Limosilactobacillus fermentum; Rats; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2013 |
Mitochondrial gene polymorphisms that protect mice from colitis.
Topics: Adenosine Triphosphate; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; DNA, Mitochondrial; Female; Genetic Predisposition to Disease; Male; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Inbred NZB; Polymorphism, Genetic; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2013 |
The role and potential therapeutic application of myeloid-derived suppressor cells in TNBS-induced colitis.
Topics: Adoptive Transfer; Animals; Body Weight; Cell Proliferation; Cell Separation; Cell Shape; Colitis; Cytokines; Dextran Sulfate; Female; Hepatic Stellate Cells; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Myeloid Cells; Spleen; Trinitrobenzenesulfonic Acid | 2013 |
Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses.
Topics: Animals; Autoimmunity; Biomarkers; Cell Differentiation; Cell Proliferation; Cell Tracking; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Green Fluorescent Proteins; Inflammation Mediators; Intestinal Mucosa; Ki-67 Antigen; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Transgenic; Receptors, G-Protein-Coupled; T-Lymphocytes, Regulatory; Th2 Cells; Time Factors; Trinitrobenzenesulfonic Acid; Wound Healing | 2013 |
Involvement of MAPK/NF-κB signaling in the activation of the cholinergic anti-inflammatory pathway in experimental colitis by chronic vagus nerve stimulation.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Female; Humans; Immunoblotting; Immunoenzyme Techniques; Inflammation; Interleukin-6; Lipopolysaccharides; Male; Mitogen-Activated Protein Kinases; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vagus Nerve Stimulation | 2013 |
Penta-O-galloyl-β-D-glucose ameliorates inflammation by inhibiting MyD88/NF-κB and MyD88/MAPK signalling pathways.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Hydrolyzable Tannins; Inflammation Mediators; Interleukin-1 Receptor-Associated Kinases; Macrophages, Peritoneal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Myeloid Differentiation Factor 88; NF-kappa B; Phosphorylation; RNA Interference; Toll-Like Receptor 4; Transfection; Trinitrobenzenesulfonic Acid | 2013 |
Intestinal epithelial vitamin D receptor signaling inhibits experimental colitis.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Colitis; Colon; Dextran Sulfate; Epithelial Cells; HCT116 Cells; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Transgenic; NF-kappa B; Receptors, Calcitriol; Signal Transduction; Tight Junctions; Transcriptional Activation; Trinitrobenzenesulfonic Acid; Tumor Suppressor Proteins | 2013 |
AVX-470: a novel oral anti-TNF antibody with therapeutic potential in inflammatory bowel disease.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies; Antibodies, Monoclonal; Blotting, Western; Cattle; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Humans; Immunoenzyme Techniques; Immunoglobulin G; Inflammation; Infliximab; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease.
Topics: Animals; Cell Movement; Cells, Cultured; Chemokine CXCL12; Colitis; Colon; Crohn Disease; Down-Regulation; Epithelial Cells; Female; Gene Expression Regulation; Humans; Interleukin-10; Mice; Mice, Inbred BALB C; Mice, Knockout; MicroRNAs; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2014 |
Design and development of novel azo prodrugs using various permutations and combinations of 5- and 4-aminosalicylic acids for inflammatory bowel disease: a colon-targeted approach.
Topics: Aminosalicylic Acid; Animals; Azo Compounds; Colitis; Colon; Drug Design; Female; Humans; Inflammatory Bowel Diseases; Male; Mesalamine; Models, Animal; Prodrugs; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2013 |
FXR mediates a chromatin looping in the GR promoter thus promoting the resolution of colitis in rodents.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Chenodeoxycholic Acid; Chromatin; Colitis; Dexamethasone; Humans; Mice; Mice, Knockout; Mifepristone; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Receptors, Glucocorticoid; Response Elements; Trinitrobenzenesulfonic Acid | 2013 |
Evaluation of ubiquitinated proteins by proteomics reveals the role of the ubiquitin proteasome system in the regulation of Grp75 and Grp78 chaperone proteins during intestinal inflammation.
Topics: Animals; Cell Line, Tumor; Colitis; Colon; Endoplasmic Reticulum Chaperone BiP; Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Interleukin-8; Intestinal Mucosa; Male; Membrane Proteins; Proteasome Endopeptidase Complex; Proteomics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Ubiquitin; Ubiquitinated Proteins | 2013 |
Maresin 1, a proresolving lipid mediator derived from omega-3 polyunsaturated fatty acids, exerts protective actions in murine models of colitis.
Topics: Animals; Cell Movement; Cells, Cultured; Colitis; Colon; Dextran Sulfate; Docosahexaenoic Acids; Inflammation; Intercellular Adhesion Molecule-1; Interferon-gamma; Interleukin-1beta; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Membrane Glycoproteins; Mice; Neutrophils; NF-kappa B; Reactive Oxygen Species; Receptors, Cell Surface; Receptors, Immunologic; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Animals; Apoptosis; Cell Proliferation; Colitis; Dietary Supplements; Disease Susceptibility; Epithelium; Hematopoietic System; Homeostasis; Humans; Interleukin-15; Intestines; Lymphocytes; Mice; Mice, Inbred C57BL; Microbiota; Nod2 Signaling Adaptor Protein; Receptor-Interacting Protein Serine-Threonine Kinase 2; Receptor-Interacting Protein Serine-Threonine Kinases; Signal Transduction; Spleen; Thymus Gland; Trinitrobenzenesulfonic Acid | 2013 |
Effects of sinomenine on the expression of microRNA-155 in 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Interferon-gamma; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Morphinans; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
A study comparing the efficacy of antimicrobial agents versus enzyme (P-gp) inducers in the treatment of 2,4,6 trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Ciprofloxacin; Colitis; Colon; Glutathione; Ileum; Male; Malondialdehyde; NF-kappa B; Peroxidase; Pregnane X Receptor; Rats; Rats, Sprague-Dawley; Receptors, Steroid; Rifampin; Spironolactone; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Nilotinib-mediated mucosal healing in a rat model of colitis.
Topics: Animals; Apoptosis; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Protein Kinase Inhibitors; Pyrimidines; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss; Wound Healing | 2013 |
Diet alters probiotic Lactobacillus persistence and function in the intestine.
Topics: Animals; Colitis; Diet; Female; Gene Expression Regulation, Bacterial; Interleukin-10; Interleukin-12; Intestines; Lactobacillus plantarum; Mice; Mice, Inbred BALB C; Microbiota; Probiotics; RNA, Ribosomal, 16S; Trinitrobenzenesulfonic Acid | 2014 |
Over-expression of CXCR4 on mesenchymal stem cells protect against experimental colitis via immunomodulatory functions in impaired tissue.
Topics: Animals; Cell Movement; Cell Survival; Cells, Cultured; Chemokine CXCL12; Colitis; Colon; Female; Gene Expression; Immunomodulation; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Sprague-Dawley; Receptors, CXCR4; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid | 2014 |
Lactobacillus reuteri-specific immunoregulatory gene rsiR modulates histamine production and immunomodulation by Lactobacillus reuteri.
Topics: Animals; Artificial Gene Fusion; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation, Bacterial; Genes, Reporter; Histamine; Humans; Immunomodulation; Limosilactobacillus reuteri; Mice; Microbiota; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2013 |
Aluminum enhances inflammation and decreases mucosal healing in experimental colitis in mice.
Topics: Aluminum; Aluminum Compounds; Animals; Cell Line; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Granuloma; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Male; Mice; Mice, Knockout; Phosphates; Trinitrobenzenesulfonic Acid; Wound Healing | 2014 |
Antidiarrheal and intestinal antiinflammatory activities of a methanolic extract of Qualea parviflora Mart. in experimental models.
Topics: Animals; Anti-Inflammatory Agents; Antidiarrheals; Castor Oil; Colitis; Colon; Diarrhea; Gastrointestinal Motility; Glutathione; Ileum; Interleukin-1beta; Male; Malondialdehyde; Methanol; Mice; Muscle Contraction; Parasympatholytics; Peroxidase; Phytotherapy; Plant Bark; Plant Extracts; Rats; Rats, Wistar; Solvents; Tracheophyta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Protective effects of Pogostemon cablin Bentham water extract on inflammatory cytokine expression in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; HT29 Cells; Humans; Intestinal Mucosa; Lamiaceae; Plant Components, Aerial; Plant Extracts; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; U937 Cells; Water | 2014 |
Prophylactic systemic P2X7 receptor blockade prevents experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Colitis; Collagen; Colon; Extracellular Signal-Regulated MAP Kinases; Gene Expression; Goblet Cells; Injections, Intraperitoneal; Macrophages; Male; NF-kappa B; Peroxidase; Purinergic P2X Receptor Antagonists; Rats; Rats, Wistar; Receptors, Purinergic P2X7; Rosaniline Dyes; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2014 |
Hymenaea stigonocarpa Mart. ex Hayne: A tropical medicinal plant with intestinal anti-inflammatory activity in TNBS model of intestinal inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Dose-Response Relationship, Drug; Hymenaea; Inflammation; Male; Plant Bark; Plant Stems; Plants, Medicinal; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2014 |
Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors.
Topics: Animals; Apoptosis; Caco-2 Cells; Cell Cycle; Cell Hypoxia; Cell Movement; Cell Survival; Chemokine CCL2; Colitis; Culture Media, Conditioned; Cytokines; Dextran Sulfate; Epithelial Cells; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Lymphocytes; Macrophages; Membrane Proteins; Mesenchymal Stem Cells; Mice; Oligonucleotide Array Sequence Analysis; Protein Array Analysis; Proto-Oncogene Proteins; Rats; Rats, Inbred Lew; Rats, Wistar; Trinitrobenzenesulfonic Acid; Up-Regulation; Vascular Endothelial Growth Factor A; Wnt Proteins; Wnt Signaling Pathway | 2014 |
Genetically engineered immunomodulatory Streptococcus thermophilus strains producing antioxidant enzymes exhibit enhanced anti-inflammatory activities.
Topics: Animals; Antioxidants; Catalase; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Immunologic Factors; Inflammation; Leukocytes, Mononuclear; Metabolic Engineering; Mice; Streptococcus thermophilus; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2014 |
Employing an IL-23 p19 vaccine to block IL-23 ameliorates chronic murine colitis.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chronic Disease; Colitis; Colon; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Immunoglobulin G; Interleukin-12; Interleukin-17; Interleukin-23; Interleukin-23 Subunit p19; Mice; Mice, Inbred BALB C; Peptides; Spleen; Trinitrobenzenesulfonic Acid; Vaccination; Vaccines, Subunit; Weight Loss | 2013 |
Comparison of experimental mouse models of inflammatory bowel disease.
Topics: Acute Disease; Animals; Caspase 1; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-4; Mice; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2014 |
Effects of interleukin-4 or interleukin-10 gene therapy on trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Genetic Therapy; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-4; Interleukin-6; Mice; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Inhibition of tumor necrosis factor-alpha and cyclooxigenase-2 by Isatin: a molecular mechanism of protection against TNBS-induced colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Enzyme Activation; Glutathione; Isatin; Rats; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Beauvericin ameliorates experimental colitis by inhibiting activated T cells via downregulation of the PI3K/Akt signaling pathway.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Depsipeptides; Disease Models, Animal; Down-Regulation; Female; Flow Cytometry; Gene Expression Regulation, Enzymologic; Inflammation; Interferon-gamma; Lymphocyte Activation; Membrane Potential, Mitochondrial; Mice; Mice, Inbred BALB C; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Signal Transduction; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
N-(2-Mercaptopropionyl)-glycine, a diffusible antioxidant, activates HIF-1 by inhibiting HIF prolyl hydroxylase-2: implication in amelioration of rat colitis by the antioxidant.
Topics: Animals; Antioxidants; Ascorbic Acid; Basic Helix-Loop-Helix Transcription Factors; Colitis; Diffusion; Enzyme Activation; HCT116 Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Male; Prolyl Hydroxylases; Rats; Rats, Sprague-Dawley; Tiopronin; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A | 2014 |
Intestinal anti-inflammatory activity of the Serpylli herba extract in experimental models of rodent colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Plant Extracts; Rats; Rats, Wistar; Thymus Plant; Trinitrobenzenesulfonic Acid | 2014 |
Anti-inflammatory effects of carbon monoxide-releasing molecule on trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Antimetabolites; Carbon Monoxide; Colitis; Colon; Cytokines; Gene Expression Regulation; Male; Mice; Organometallic Compounds; Peroxidase; Spleen; Trinitrobenzenesulfonic Acid | 2014 |
Induction of murine TNBS colitis is strictly controlled by a modified method using continuous inhalation anesthesia with sevoflurane.
Topics: Anesthesia, Inhalation; Anesthetics; Anesthetics, Inhalation; Animals; Biomarkers; Colitis; Cytokines; Disease Models, Animal; Drug Administration Schedule; Enema; Ethanol; Female; Injections, Intraperitoneal; Methyl Ethers; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Real-Time Polymerase Chain Reaction; Sevoflurane; Trinitrobenzenesulfonic Acid | 2014 |
Role of metallothioneins as danger signals in the pathogenesis of colitis.
Topics: Acute Disease; Adolescent; Adult; Aged; Aged, 80 and over; Animals; Antibodies; Apoptosis; Biopsy; Case-Control Studies; Chemotaxis, Leukocyte; Chronic Disease; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Female; HT29 Cells; Humans; Macrophages; Male; Metallothionein; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Necrosis; Severity of Illness Index; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Young Adult | 2014 |
A 3-D artificial colon tissue mimic for the evaluation of nanoparticle-based drug delivery system.
Topics: Animals; Biomimetics; Caco-2 Cells; Colitis; Colon; Cytokines; Drug Delivery Systems; Drug Evaluation; Extracellular Matrix; Female; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Leukocytes; Mice; Mice, Inbred BALB C; Mucus; Nanoparticles; Trinitrobenzenesulfonic Acid | 2014 |
Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: a potential pharmacologic mechanism and therapeutic advantages.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Celecoxib; Cell Line; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Gene Expression Regulation; Humans; Male; Mice; Prodrugs; Pyrazoles; Rats; Sulfonamides; Trinitrobenzenesulfonic Acid | 2014 |
Urocortin 3 expression at baseline and during inflammation in the colon: corticotropin releasing factor receptors cross-talk.
Topics: Animals; Body Weight; Colitis; Colon; Disease Models, Animal; Gene Knockdown Techniques; Male; Organ Size; Phosphorylation; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reference Values; RNA Interference; Spleen; Trinitrobenzenesulfonic Acid; Urocortins | 2014 |
Analgesic effect of minocycline in rat model of inflammation-induced visceral pain.
Topics: Analgesics; Animals; Behavior, Animal; Colitis; Colon; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Mechanotransduction, Cellular; Microglia; Minocycline; Pain Perception; Pressure; Rats, Sprague-Dawley; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Visceral Pain | 2014 |
Effect of glucans from Caripia montagnei mushroom on TNBS-induced colitis.
Topics: Agaricales; Alkaline Phosphatase; Animals; Catalase; Colitis; Cytokines; Disease Models, Animal; Enzyme Activation; Glucans; Intestinal Mucosa; Male; Nitric Oxide; Nuclear Magnetic Resonance, Biomolecular; Peroxidase; Rats; Spectroscopy, Fourier Transform Infrared; Trinitrobenzenesulfonic Acid | 2014 |
Tissue-expressed B7-H1 critically controls intestinal inflammation.
Topics: Animals; Bone Marrow Cells; Colitis; Humans; Immunity, Innate; Inflammation; Interleukin-22; Interleukins; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Programmed Cell Death 1 Receptor; Sodium Dodecyl Sulfate; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Use of artificial cell microcapsule containing thalidomide for treating TNBS-induced Crohn's disease in mice.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Biomarkers; Capsules; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Particle Size; Peroxidase; Polylysine; Solubility; Technology, Pharmaceutical; Thalidomide; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Prolactin mediates psychological stress-induced dysfunction of regulatory T cells to facilitate intestinal inflammation.
Topics: Animals; Cabergoline; Colitis; Dextran Sulfate; Disease Models, Animal; Dopamine Agonists; Ergolines; Forkhead Transcription Factors; Immunity, Mucosal; Inflammation; Interleukins; Mice; Mice, Inbred BALB C; Prolactin; Stress, Psychological; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Osteopontin expression by CD103- dendritic cells drives intestinal inflammation.
Topics: Adoptive Transfer; Animals; Antibodies, Neutralizing; Antigens, CD; Colitis; Dendritic Cells; DNA Primers; Flow Cytometry; Integrin alpha Chains; Integrins; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; Osteopontin; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2014 |
Histamine H4 and H1 receptors contribute to postinflammatory visceral hypersensitivity.
Topics: Animals; Cetirizine; Colitis; Colonoscopy; Convalescence; Disease Models, Animal; Histamine; Histamine H1 Antagonists, Non-Sedating; Histamine Release; Hypersensitivity; Indoles; Intestinal Mucosa; Male; Mast Cells; Piperazines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H1; Receptors, Histamine H4; Regeneration; Trinitrobenzenesulfonic Acid | 2014 |
Sulfated-polysaccharide fraction extracted from red algae Gracilaria birdiae ameliorates trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Colitis; Colon; Cytokines; Dexamethasone; Glutathione; Gracilaria; Inflammation; Lipid Peroxidation; Male; Malondialdehyde; Nitrates; Nitrites; Peroxidase; Polysaccharides; Rats; Rats, Wistar; Rhodophyta; Trinitrobenzenesulfonic Acid | 2014 |
Colonic expression of the peptide transporter PEPT1 is downregulated during intestinal inflammation and is not required for NOD2-dependent immune activation.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adolescent; Adult; Aged; Animals; Colitis; Colitis, Ulcerative; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Female; Gene Knockdown Techniques; Genotype; Humans; Ileitis; Immunity, Mucosal; Male; Mice; Mice, Inbred C57BL; Middle Aged; Nod2 Signaling Adaptor Protein; Peptide Transporter 1; Polymorphism, Single Nucleotide; RNA, Messenger; Symporters; Tissue Culture Techniques; Trinitrobenzenesulfonic Acid; Young Adult | 2014 |
Neuron-glial communication mediated by TNF-α and glial activation in dorsal root ganglia in visceral inflammatory hypersensitivity.
Topics: Animals; Animals, Newborn; Antibodies, Monoclonal; Behavior, Animal; Cell Communication; Cell Surface Extensions; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglia, Spinal; Gap Junctions; Hyperalgesia; Inflammation Mediators; Male; Neuroglia; Neurons; Pain Threshold; Pressure; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
IL-13 orchestrates resolution of chronic intestinal inflammation via phosphorylation of glycogen synthase kinase-3β.
Topics: Animals; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Enzyme Activation; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Interleukin-13; Mice; Mice, Inbred BALB C; Mice, Knockout; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Signal Transduction; Trinitrobenzenesulfonic Acid | 2014 |
Concentrated grape juice (G8000™) reduces immunoexpression of iNOS, TNF-alpha, COX-2 and DNA damage on 2,4,6-trinitrobenzene sulfonic acid-induced-colitis.
Topics: Animals; Anti-Inflammatory Agents; Beverages; Colitis; Colon; Comet Assay; Cyclooxygenase 2; DNA Damage; Fruit; Male; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vitis | 2014 |
DNBS/TNBS colitis models: providing insights into inflammatory bowel disease and effects of dietary fat.
Topics: Animals; Colitis; Dietary Fats; Dinitrofluorobenzene; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2014 |
Anti-inflammatory effect of recreational exercise in TNBS-induced colitis in rats: role of NOS/HO/MPO system.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Gene Expression Profiling; Heme Oxygenase (Decyclizing); Inflammation Mediators; Intestinal Mucosa; Male; Nitric Oxide Synthase; Peroxidase; Physical Conditioning, Animal; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Andrographolide sulfonate ameliorates experimental colitis in mice by inhibiting Th1/Th17 response.
Topics: Alkanesulfonates; Animals; Body Weight; Colitis; Colon; Cytokines; Diterpenes; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Models, Animal; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Peroxidase; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2014 |
The synthetic triterpenoid (CDDO-Im) inhibits STAT3, as well as IL-17, and improves DSS-induced colitis in mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Imidazoles; Inflammation; Inhibitory Concentration 50; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Oleanolic Acid; Spleen; STAT3 Transcription Factor; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Jun kinase-induced overexpression of leukemia-associated Rho GEF (LARG) mediates sustained hypercontraction of longitudinal smooth muscle in inflammation.
Topics: Animals; Colitis; Colon; Death-Associated Protein Kinases; Gene Expression Regulation; Inflammation; JNK Mitogen-Activated Protein Kinases; Mice; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Organ Culture Techniques; Peptide Fragments; Phosphorylation; Rho Guanine Nucleotide Exchange Factors; Signal Transduction; Trinitrobenzenesulfonic Acid | 2014 |
Hepcidin expression in colon during trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Colitis; Colon; Enzyme-Linked Immunosorbent Assay; Gene Expression Profiling; Gene Expression Regulation; Hepcidins; Interleukin-10; Interleukin-6; Iron; Male; Peroxidase; Phosphorylation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Intestinal anti-inflammatory effects of oligosaccharides derived from lactulose in the trinitrobenzenesulfonic acid model of rat colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Disease Models, Animal; Female; Humans; Interleukins; Intestines; Lactulose; Microbiota; Oligosaccharides; Prebiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2014 |
Protective effect of 7-O-succinyl macrolactin A against intestinal inflammation is mediated through PI3-kinase/Akt/mTOR and NF-κB signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Cell Adhesion; Cell Survival; Colitis; Colon; Cytokines; Female; HT29 Cells; Humans; Macrolides; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; TOR Serine-Threonine Kinases; Trinitrobenzenesulfonic Acid; U937 Cells | 2014 |
Hypercontractility of intestinal longitudinal smooth muscle induced by cytokines is mediated by the nuclear factor-κB/AMP-activated kinase/myosin light chain kinase pathway.
Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Benzimidazoles; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Carrier Proteins; Colitis; Colon; Cytokines; Drug Interactions; Interleukin-1beta; Leupeptins; Male; Mice; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Naphthalimides; NF-kappa B; Peptide Fragments; Phosphorylation; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts.
Topics: Animals; Cell Line; Colitis; Collagen Type I; Colon; Disease Models, Animal; Down-Regulation; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Fibrosis; Insulin-Like Growth Factor I; Male; MAP Kinase Kinase Kinases; Mice; Mutation; Phosphorylation; Rats, Sprague-Dawley; Receptor, IGF Type 1; Resveratrol; RNA Interference; RNA, Messenger; Signal Transduction; Sirtuin 1; Stilbenes; Transfection; Trinitrobenzenesulfonic Acid | 2014 |
Camel's milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Camelus; Caspase 3; Caspase Inhibitors; Colitis; Cytokines; Down-Regulation; Interleukin-10; Leukocytes; Milk; Oxidative Stress; Peroxidase; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Lactobacillus plantarum CLP-0611 ameliorates colitis in mice by polarizing M1 to M2-like macrophages.
Topics: Administration, Oral; Animals; Cell Differentiation; Cells, Cultured; Colitis; Colon; Cytokines; Interleukin-1 Receptor-Associated Kinases; Lactobacillus plantarum; Lipopolysaccharides; Macrophages, Peritoneal; Male; MAP Kinase Signaling System; Mice; Mice, Inbred ICR; NF-kappa B; Peroxidase; Probiotics; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2014 |
Continuous flushing of the bladder in rodents reduces artifacts and improves quantification in molecular imaging.
Topics: Animals; Colitis; Colonoscopy; Female; Fluorodeoxyglucose F18; Image Processing, Computer-Assisted; Mice; Molecular Imaging; Positron-Emission Tomography; Radiopharmaceuticals; Rats; Tomography, X-Ray Computed; Trinitrobenzenesulfonic Acid; Urinary Bladder | 2014 |
Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Antioxidants; Apoptosis; Benzimidazoles; Benzoates; Colitis; Colon; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Immunohistochemistry; Inflammation; Inflammatory Bowel Diseases; Lipid Peroxidation; Male; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Telmisartan; Trinitrobenzenesulfonic Acid | 2014 |
Hirsutenone reduces deterioration of tight junction proteins through EGFR/Akt and ERK1/2 pathway both converging to HO-1 induction.
Topics: Animals; Caco-2 Cells; Catechols; Colitis; Diarylheptanoids; Disease Models, Animal; ErbB Receptors; Gene Expression Regulation; Heme Oxygenase-1; Humans; Intestinal Mucosa; Mice; Mitogen-Activated Protein Kinase 3; Occludin; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; tert-Butylhydroperoxide; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2014 |
Glugacon-like peptide-2: broad receptor expression, limited therapeutic effect on intestinal inflammation and novel role in liver regeneration.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Enteroendocrine Cells; Gastrointestinal Agents; Gene Expression Regulation; Glucagon-Like Peptide 2; Glucagon-Like Peptide-2 Receptor; Hep G2 Cells; Hepatectomy; HT29 Cells; Humans; Jurkat Cells; Liver; Liver Regeneration; Mice; Mice, Inbred C57BL; Peptide Fragments; Rats; Receptors, Glucagon; Recombinant Proteins; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Effect of mesalamine and prednisolone on TNBS experimental colitis, following various doses of orally administered iron.
Topics: Administration, Oral; Animals; Colitis; Dietary Supplements; Dose-Response Relationship, Drug; Intestinal Mucosa; Iron; Male; Malondialdehyde; Mesalamine; Prednisolone; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
A mixed formulation of lactic acid bacteria inhibits trinitrobenzene-sulfonic-acid-induced inflammatory changes of the colon tissue in mice.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Cell Line; Colitis; Colon; Disease Models, Animal; Lactobacillales; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Probiotics; Trinitrobenzenesulfonic Acid | 2014 |
Efficacy of thalidomide on trinitrobenzene sulfonate-induced colitis in young rats and its mechanism.
Topics: Animals; Colitis; Cytokines; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-1beta; NF-kappa B; Rats; Rats, Sprague-Dawley; Thalidomide; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Colitis; Colon; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 4; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gastrointestinal Motility; Inflammation Mediators; Interleukin-1beta; Male; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Relaxation; Muscle, Smooth; Nitric Oxide Synthase Type II; Phosphorylation; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2014 |
Mangiferin ameliorates colitis by inhibiting IRAK1 phosphorylation in NF-κB and MAPK pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Interleukin-1 Receptor-Associated Kinases; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Peptidoglycan; Phosphorylation; Trinitrobenzenesulfonic Acid; Xanthones | 2014 |
Magnetic resonance colonography for fibrosis assessment in rats with chronic colitis.
Topics: Animals; Chronic Disease; Colitis; Colonoscopy; Constriction, Pathologic; Feasibility Studies; Fibrosis; Magnetic Resonance Imaging; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2014 |
Pathological activation of canonical nuclear-factor κB by synergy of tumor necrosis factor α and TNF-like weak inducer of apoptosis in mouse acute colitis.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Cytokine TWEAK; Gene Expression Profiling; Inflammation; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; NF-kappa B; NF-kappa B p50 Subunit; Receptors, Tumor Necrosis Factor; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Tumor Necrosis Factors; TWEAK Receptor | 2014 |
Polyphenol extract from evening primrose pomace alleviates experimental colitis after intracolonic and oral administration in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Free Radical Scavengers; Hydrogen Peroxide; Interleukin-1beta; Male; Mass Spectrometry; Mice; Mice, Inbred C57BL; Oenothera biennis; Plant Extracts; Polyphenols; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
The effect of chemically induced colitis, psychological stress and their combination on visceral pain in female Wistar rats.
Topics: Animals; Colitis; Female; Hyperalgesia; Rats; Rats, Wistar; Stress, Psychological; Trinitrobenzenesulfonic Acid; Visceral Pain | 2014 |
Lactococcus lactis carrying the pValac DNA expression vector coding for IL-10 reduces inflammation in a murine model of experimental colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Genetic Therapy; Genetic Vectors; Immunoglobulin A; Inflammation; Interleukin-10; Interleukin-6; Lactococcus lactis; Mice; Mice, Inbred C57BL; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2014 |
Preventive effects of Escherichia coli strain Nissle 1917 with different courses and different doses on intestinal inflammation in murine model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Escherichia coli; Female; Ileum; Interleukin-10; Intestinal Mucosa; Peroxidase; Probiotics; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2014 |
Effect of Astragalus polysaccharides on expression of TNF-α, IL-1β and NFATc4 in a rat model of experimental colitis.
Topics: Animals; Astragalus propinquus; Body Weight; Colitis; Colon; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Interleukin-1beta; Male; Nerve Tissue Proteins; NFATC Transcription Factors; Polysaccharides; Rats, Wistar; Real-Time Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: new potential treatment of abdominal pain associated with inflammatory bowel diseases.
Topics: Abdominal Pain; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Enkephalins; Inflammation; Inflammatory Bowel Diseases; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Inbred BALB C; Mustard Plant; Plant Oils; Trinitrobenzenesulfonic Acid | 2014 |
Beneficial effect of butyrate, Lactobacillus casei and L-carnitine combination in preference to each in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Butyric Acid; Carnitine; Colitis; Colon; Combined Modality Therapy; Disease Models, Animal; Gastrointestinal Agents; Inflammation Mediators; Lacticaseibacillus casei; Male; Oxidative Stress; Probiotics; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Preventive effect of the microalga Chlamydomonas debaryana on the acute phase of experimental colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Biomass; Chlamydomonas; Colitis; Colon; Cyclooxygenase 2; Fatty Acids, Omega-3; Freeze Drying; Linoleic Acids; Male; Neutrophils; Nitric Oxide Synthase Type II; Oxylipins; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Ursolic acid isolated from the seed of Cornus officinalis ameliorates colitis in mice by inhibiting the binding of lipopolysaccharide to Toll-like receptor 4 on macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cornus; Cytokines; Inflammation Mediators; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; NF-kappa B; Peptidoglycan; Seeds; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Triterpenes; Ursolic Acid | 2014 |
Divergent influence of microRNA-21 deletion on murine colitis phenotypes.
Topics: Animals; Biomarkers; Blotting, Western; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; DNA-Binding Proteins; Female; Gene Deletion; Gene Expression Profiling; Humans; Immunoenzyme Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Oligonucleotide Array Sequence Analysis; Phenotype; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2014 |
Mitigation of colitis with NovaSil clay therapy.
Topics: Aluminum Silicates; Animals; Anti-Inflammatory Agents; Bacteria; Clay; Colitis; Colon; Crystallography, X-Ray; Cytokines; Disease Models, Animal; Feces; Female; Gastrointestinal Agents; Inflammation Mediators; Mice, Inbred BALB C; Microscopy, Electron, Transmission; Powder Diffraction; Ribotyping; Silicates; Time Factors; Trinitrobenzenesulfonic Acid; Weight Gain | 2015 |
Novel orally available salvinorin A analog PR-38 protects against experimental colitis and reduces abdominal pain in mice by interaction with opioid and cannabinoid receptors.
Topics: Abdominal Pain; Administration, Oral; Analgesics; Animals; Colitis; Diterpenes, Clerodane; Male; Mice; Mice, Inbred C57BL; Receptors, Cannabinoid; Receptors, Opioid; Trinitrobenzenesulfonic Acid | 2014 |
Baicalin attenuates TNBS-induced colitis in rats by modulating the Th17/Treg paradigm.
Topics: Animals; Blotting, Western; Colitis; Cytokines; Disease Models, Animal; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Flavonoids; Flow Cytometry; Immunologic Factors; Inflammation Mediators; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Effectiveness of sildenafil and U-74389G in a rat model of colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Male; Malondialdehyde; Phosphodiesterase 5 Inhibitors; Piperazines; Pregnatrienes; Purines; Random Allocation; Rats, Wistar; Sildenafil Citrate; Sulfones; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.
Topics: Animals; Case-Control Studies; Cell Line; Claudin-1; Colitis; Colon; Disease Models, Animal; Down-Regulation; Gene Knockdown Techniques; Genetic Predisposition to Disease; Humans; Inflammatory Bowel Diseases; Male; Mice, Inbred C57BL; Mice, Knockout; MicroRNAs; Permeability; Phenotype; Repressor Proteins; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
Colitis generates remote antinociception in rats: the role of the L-arginine/NO/cGMP/PKG/KATP pathway and involvement of cannabinoid and opioid systems.
Topics: Analgesics, Opioid; Animals; Arginine; Cannabinoids; Carrageenan; Colitis; Colon; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Dinoprostone; KATP Channels; Male; Neurons; Nitric Oxide; Nociception; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2014 |
Homocysteine promotes intestinal fibrosis in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Collagen Type I; Collagen Type III; Colon; Cytokines; Disease Models, Animal; Ethanol; Fibrosis; Homocysteine; Hyperhomocysteinemia; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Mesenchymal stem cells and conditioned medium avert enteric neuropathy and colon dysfunction in guinea pig TNBS-induced colitis.
Topics: Animals; Cell Movement; Colitis; Colon; Culture Media, Conditioned; Enteric Nervous System; Female; Gastrointestinal Motility; Humans; Male; Mesenchymal Stem Cell Transplantation; Mice; Peripheral Nervous System Diseases; Trinitrobenzenesulfonic Acid; Weight Loss | 2014 |
Vasoactive intestinal peptide-deficient mice exhibit reduced pathology in trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Cell Proliferation; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; RNA, Messenger; T-Lymphocytes; Time Factors; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2015 |
The neurotensin-HIF-1α-VEGFα axis orchestrates hypoxia, colonic inflammation, and intestinal angiogenesis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Endothelial Cells; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mice; Microcirculation; Neovascularization, Pathologic; Receptors, Neurotensin; Trinitrobenzenesulfonic Acid; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
Ly49E expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases.
Topics: Animals; CD8 Antigens; Cell Count; Colitis; Colon; Dextran Sulfate; Disease Progression; Epithelial Cells; Ileitis; Inflammatory Bowel Diseases; Intestines; Lymphocytes; Mice, Inbred C57BL; Mice, Knockout; NK Cell Lectin-Like Receptor Subfamily A; Receptors, Natural Killer Cell; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
Amelioration of trinitrobenzene sulfonic acid-induced colitis in mice by liquiritigenin.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Flavanones; Inflammation Mediators; Male; Mesalamine; Mice, Inbred ICR; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-12; Intestinal Mucosa; Prebiotics; Random Allocation; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms; Sulfasalazine; Toll-Like Receptor 2; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Trisaccharides | 2015 |
Milk fermented with a 15-lipoxygenase-1-producing Lactococcus lactis alleviates symptoms of colitis in a murine model.
Topics: Animals; Anti-Inflammatory Agents; Arachidonate 15-Lipoxygenase; Colitis; Disease Models, Animal; Female; Fermentation; Lactococcus lactis; Mice, Inbred BALB C; Milk; Trinitrobenzenesulfonic Acid | 2015 |
Maternal exposure to low levels of corticosterone during lactation protects against experimental inflammatory colitis-induced damage in adult rat offspring.
Topics: Animals; Animals, Newborn; Blotting, Western; Body Weight; Chymases; Colitis; Colon; Corticosterone; Corticotropin-Releasing Hormone; Eating; Female; Immunohistochemistry; Lactation; Male; Peroxidase; Protective Agents; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Trinitrobenzenesulfonic Acid | 2014 |
Pelvic organ cross-sensitization to enhance bladder and urethral pain behaviors in rats with experimental colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Diterpenes; Female; Freezing Reaction, Cataleptic; Ganglia, Spinal; Grooming; Neurons, Afferent; Pain; Peroxidase; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Urethra; Urinary Bladder | 2015 |
In vivo efficacy of microbiota-sensitive coatings for colon targeting: a promising tool for IBD therapy.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cellulose; Colitis; Colon; Dextrins; Drug Delivery Systems; Hydroxymethylglutaryl-CoA Synthase; Interleukin-1beta; Male; Mesalamine; Mice, Transgenic; Microbiota; Peroxidase; PPAR gamma; Rats, Wistar; RNA, Messenger; Starch; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Therapeutic efficacy of quercetin enzyme-responsive nanovesicles for the treatment of experimental colitis in rats.
Topics: Animals; Antioxidants; Chitosan; Coated Materials, Biocompatible; Colitis; Drug Carriers; Male; Nanoparticles; Quercetin; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2015 |
Alleviated mucosal and neuronal damage in a rat model of Crohn's disease.
Topics: Animals; Colitis; Colon; Crohn Disease; Disease Models, Animal; Heme Oxygenase (Decyclizing); Intestinal Mucosa; Male; Myenteric Plexus; Rats, Sprague-Dawley; Recurrence; Remission Induction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2014 |
Biochemical and histopathological evidence on the beneficial effects of Tragopogon graminifolius in TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Lipid Peroxidation; Male; Plant Components, Aerial; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Tragopogon; Trinitrobenzenesulfonic Acid | 2015 |
Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity.
Topics: Animals; Ascorbic Acid; Carboxylic Acids; Cell Line, Tumor; Cinnamates; Coenzymes; Colitis; Depsides; Enzyme Inhibitors; Esters; Humans; Hydrophobic and Hydrophilic Interactions; Hydroxylation; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Ketoglutaric Acids; Protein Stability; Rats; Rosmarinic Acid; Signal Transduction; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A | 2015 |
Inhibition of plasmin protects against colitis in mice by suppressing matrix metalloproteinase 9-mediated cytokine release from myeloid cells.
Topics: Animals; CD40 Antigens; Chemokine CXCL5; Colitis; Dextran Sulfate; Dipeptides; Disease Models, Animal; Fibrinolysin; Inflammation; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Macrophages; Matrix Metalloproteinase 9; Mice; Mice, Knockout; Myeloid Cells; Neutrophils; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Electroacupuncture ameliorates experimental colitis induced by TNBS through activation of interleukin-10 and inhibition of iNOS in mice.
Topics: Acupuncture Points; Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Electroacupuncture; Immunohistochemistry; Inflammatory Bowel Diseases; Interleukin-10; Interleukin-1beta; Male; Malondialdehyde; Mice; Nitric Oxide Synthase Type II; Peroxidase; Random Allocation; Trinitrobenzenesulfonic Acid | 2014 |
Lactosucrose attenuates intestinal inflammation by promoting Th2 cytokine production and enhancing CD86 expression in colitic rats.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; B7-1 Antigen; B7-2 Antigen; Colitis; Colon; Dendritic Cells; Female; Gene Expression Regulation; Inflammation; Interferon-gamma; Interleukin-10; Interleukin-4; Intestinal Mucosa; Peroxidase; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Th1-Th2 Balance; Trinitrobenzenesulfonic Acid; Trisaccharides | 2015 |
Vacuolar protein sorting 4B regulates apoptosis of intestinal epithelial cells via p38 MAPK in Crohn's disease.
Topics: Adenosine Triphosphatases; Animals; Apoptosis; ATPases Associated with Diverse Cellular Activities; Blotting, Western; Caspase 3; Cell Proliferation; Colitis; Crohn Disease; Endosomal Sorting Complexes Required for Transport; Epithelial Cells; Female; HT29 Cells; Humans; Immunoenzyme Techniques; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Nude; p38 Mitogen-Activated Protein Kinases; RNA, Small Interfering; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2015 |
Oral delivery of prolyl hydroxylase inhibitor: AKB-4924 promotes localized mucosal healing in a mouse model of colitis.
Topics: Administration, Oral; Animals; Colitis; Disease Models, Animal; Female; Hypoxia-Inducible Factor 1; Immunoenzyme Techniques; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mucous Membrane; Piperazines; Prolyl-Hydroxylase Inhibitors; Pyridones; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
Zeyheria montana Mart. (Bignoniaceae) as source of antioxidant and immunomodulatory compounds with beneficial effects on intestinal inflammation.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Bignoniaceae; Brazil; Colitis; Flavonoids; Immunologic Factors; Inflammation; Inflammatory Bowel Diseases; Intestines; Lipid Peroxidation; Male; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Plant Leaves; Trinitrobenzenesulfonic Acid | 2015 |
2,4,6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling.
Topics: Animals; Boronic Acids; Bortezomib; Chronic Disease; Colitis; Colon; Disease Models, Animal; Fibrosis; Male; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Pyrazines; Rats, Sprague-Dawley; Signal Transduction; Tight Junction Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2014 |
Bifidobacterium infantis attenuates colitis by regulating T cell subset responses.
Topics: Animals; Bifidobacterium; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Mice, Inbred BALB C; Probiotics; Severity of Illness Index; T-Lymphocyte Subsets; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2014 |
Early inflammatory damage to intestinal neurons occurs via inducible nitric oxide synthase.
Topics: Animals; Cell Line; Coculture Techniques; Colitis; Disease Models, Animal; Enteric Nervous System; Female; Hyperplasia; Macrophages; Male; Mice, Inbred BALB C; Mice, Inbred C3H; Muscle, Smooth; Neuroimmunomodulation; Neurons; Neutrophils; Nitric Oxide; Nitric Oxide Synthase Type II; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Altered vasoactive intestinal peptides expression in irritable bowel syndrome patients and rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Adult; Animals; Biomarkers; Case-Control Studies; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Regulation; Humans; Hyperalgesia; Inflammation Mediators; Irritable Bowel Syndrome; Male; Middle Aged; Pain Threshold; Peroxidase; Pilot Projects; Rats, Sprague-Dawley; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide; Visceral Pain; Weight Loss; Young Adult | 2015 |
PF2405, standardized fraction of Scutellaria baicalensis, ameliorates colitis in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cyclooxygenase 2 Inhibitors; Dextran Sulfate; Female; HT29 Cells; Humans; Interleukin-1beta; MAP Kinase Kinase 4; Mice; Mice, Inbred C57BL; Phosphorylation; Plant Extracts; Scutellaria baicalensis; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Insulin-like growth factor-1 endues monocytes with immune suppressive ability to inhibit inflammation in the intestine.
Topics: Animals; Cell Line; Cell Separation; Colitis; Epithelial Cells; Immunosuppression Therapy; Inflammation; Insulin-Like Growth Factor I; Interleukin-10; Intestines; Lipopolysaccharide Receptors; Mice, Inbred BALB C; Monocytes; Oligodeoxyribonucleotides; Phenotype; Receptor, IGF Type 1; Spleen; Trinitrobenzenesulfonic Acid | 2015 |
Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1.
Topics: Abdominal Fat; Adipocytes, White; Adipokines; Animals; Case-Control Studies; Cells, Cultured; Colitis; Colon; Culture Media, Conditioned; Cytokines; Disease Models, Animal; Female; Gene Expression Regulation; Gene Knockdown Techniques; Humans; Inflammation Mediators; Male; Mice, Inbred C57BL; Obesity; Receptors, Adiponectin; RNA Interference; RNA, Messenger; Severity of Illness Index; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid | 2015 |
Intestinal anti-inflammatory activity of apigenin K in two rat colitis models induced by trinitrobenzenesulfonic acid and dextran sulphate sodium.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apigenin; Biomarkers; Colitis; Colon; Dextran Sulfate; Dietary Supplements; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Organ Size; Pilot Projects; Random Allocation; Rats, Wistar; Solubility; Trinitrobenzenesulfonic Acid | 2015 |
Intestinal smooth muscle phenotype determines enteric neuronal survival via GDNF expression.
Topics: Animals; Axons; Cattle; Cell Proliferation; Cell Survival; Coculture Techniques; Colitis; Enteric Nervous System; Glial Cell Line-Derived Neurotrophic Factor; Intestines; Male; Mice, Inbred BALB C; Muscle, Smooth; Neurons; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
Citrus nobiletin ameliorates experimental colitis by reducing inflammation and restoring impaired intestinal barrier function.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Citrus; Colitis; Cytokines; Flavones; Humans; Intestinal Mucosa; Intestines; Male; Myosin-Light-Chain Kinase; Neutrophil Infiltration; NF-kappa B; Permeability; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2015 |
[Experimental study of adipose-derived mesenchymal stem cells in the treatment of Crohn's disease].
Topics: Adipocytes; Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Down-Regulation; Female; Inflammatory Bowel Diseases; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Timosaponin AIII and its metabolite sarsasapogenin ameliorate colitis in mice by inhibiting NF-κB and MAPK activation and restoring Th17/Treg cell balance.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Colitis; Colon; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; NF-kappa B; Peroxidase; Saponins; Spirostans; Steroids; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
The viability of Lactobacillus fermentum CECT5716 is not essential to exert intestinal anti-inflammatory properties.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Colitis; Female; Gastrointestinal Microbiome; Humans; Immunomodulation; Interleukin-1beta; Interleukin-8; Intestinal Mucosa; Intestines; Limosilactobacillus fermentum; Mice; Microbial Viability; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Probiotics; Rats; Rats, Wistar; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Sensory and inflammatory colonic changes induced by vincristine in distinct rat models of colitis.
Topics: Animals; Antineoplastic Agents, Phytogenic; Colitis; Colon; Disease Models, Animal; Drug Interactions; Male; Mustard Plant; Pain Threshold; Plant Oils; Rats; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Vincristine | 2015 |
Experimental colitis in mice is attenuated by topical administration of chlorogenic acid.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Chlorogenic Acid; Colitis; Colon; Hydrogen Peroxide; Male; Mice, Inbred BALB C; NF-kappa B; Peroxidase; Trinitrobenzenesulfonic Acid | 2015 |
Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice.
Topics: Animals; Antigens, Surface; Apoptosis; Cell Line; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Milk Proteins; Protective Agents; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 2015 |
The potential protective role of caveolin-1 in intestinal inflammation in TNBS-induced murine colitis.
Topics: Animals; Caveolin 1; Colitis; Collagen; Cytokines; Female; Male; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2015 |
Polyphosphate, an active molecule derived from probiotic Lactobacillus brevis, improves the fibrosis in murine colitis.
Topics: Animals; Caco-2 Cells; Chronic Disease; Colitis; Collagen; Colon; Connective Tissue Growth Factor; Cytokines; Dextran Sulfate; Epithelial Cells; Fibrosis; Humans; Inflammation; Inflammation Mediators; Levilactobacillus brevis; Macrophages; Mice, Inbred C57BL; Polyphosphates; Probiotics; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Reducing colorectal anastomotic leakage with tissue adhesive in experimental inflammatory bowel disease.
Topics: Anastomosis, Surgical; Anastomotic Leak; Animals; Colectomy; Colitis; Disease Models, Animal; Male; Postoperative Complications; Rats; Rats, Wistar; Tissue Adhesives; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
Vitamin D/VDR signaling pathway ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis by inhibiting intestinal epithelial apoptosis.
Topics: Animals; Apoptosis; Case-Control Studies; Colitis; Cytokines; Disease Models, Animal; Gene Expression Regulation; Humans; Inflammation Mediators; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Permeability; Receptors, Calcitriol; Signal Transduction; Trinitrobenzenesulfonic Acid; Vitamin D | 2015 |
Royal Jelly and its dual role in TNBS colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Cyclooxygenase 2; Disease Models, Animal; Fatty Acids; Female; Functional Food; Glutathione; Glutathione Peroxidase; Humans; Mice; NF-kappa B; Trinitrobenzenesulfonic Acid | 2015 |
Triptolide ameliorates colonic fibrosis in an experimental rat model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Collagen; Collagen Type I; Colon; Diterpenes; Epoxy Compounds; Extracellular Matrix; Fibrosis; Male; Myofibroblasts; Phenanthrenes; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2015 |
Crotoxin from Crotalus durissus terrificus is able to down-modulate the acute intestinal inflammation in mice.
Topics: Animals; Colitis; Crotalus; Crotoxin; Forkhead Transcription Factors; Inflammation Mediators; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Peroxidase; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Catecholamine Mediates Psychological Stress-Induced Colitis Through a2-Adrenoreceptor.
Topics: Animals; Catecholamines; Colitis; Dopamine beta-Hydroxylase; Humans; Inflammatory Bowel Diseases; Male; Mice, Inbred BALB C; Receptors, Adrenergic, alpha-2; Stress, Psychological; Trinitrobenzenesulfonic Acid | 2015 |
Protective effects of Semen Crotonis Pulveratum on trinitrobenzene sulphonic acid-induced colitis in rats and H₂O₂-induced intestinal cell apoptosis in vitro.
Topics: Animals; Apoptosis; Colitis; Croton; Female; Hydrogen Peroxide; Intestinal Mucosa; Plant Extracts; Rats; Rats, Wistar; Seeds; Trinitrobenzenesulfonic Acid | 2015 |
P2X3 receptors mediate visceral hypersensitivity during acute chemically-induced colitis and in the post-inflammatory phase via different mechanisms of sensitization.
Topics: Adenosine Triphosphate; Animals; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Inflammation; Male; Phenols; Polycyclic Compounds; Purinergic P2X Receptor Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2X3; Trinitrobenzenesulfonic Acid | 2015 |
Effect of 3-aminobenzamide on perforation an experimental colitis model.
Topics: Animals; Benzamides; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Intestinal Perforation; Lipid Peroxidation; Male; Malondialdehyde; Pressure; Rats; Rats, Wistar; Rupture; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2014 |
A new therapeutic association to manage relapsing experimental colitis: Doxycycline plus Saccharomyces boulardii.
Topics: Animals; Anti-Bacterial Agents; Caco-2 Cells; Colitis; Combined Modality Therapy; Cytokines; Dextran Sulfate; Doxycycline; Epithelial Cells; Female; Humans; Interleukin-8; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Probiotics; Rats; Rats, Wistar; Recurrence; Saccharomyces; Trinitrobenzenesulfonic Acid | 2015 |
AMP-18 Targets p21 to Maintain Epithelial Homeostasis.
Topics: Animals; Apoptosis; Caspase 3; Cell Cycle; Cell Nucleus; Cell Proliferation; Colitis; Cyclin-Dependent Kinase Inhibitor p21; Epithelial Cells; Homeostasis; Humans; Mice; Peptide Hormones; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Transport; Proto-Oncogene Proteins c-akt; Rats; Signal Transduction; Subcellular Fractions; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Validation of a modified model of TNBS-induced colitis in rats. How to induce a chemical colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Instillation, Drug; Male; Rats; Rats, Wistar; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2015 |
Herbal prescription Chang'an II repairs intestinal mucosal barrier in rats with post-inflammation irritable bowel syndrome.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Behavior, Animal; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Drug Combinations; Drugs, Chinese Herbal; Feces; Feeding Behavior; Food Preferences; Gastrointestinal Agents; Immunity, Mucosal; Inflammation Mediators; Interleukin-1beta; Interleukin-4; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Medicine, Chinese Traditional; Motor Activity; Pain Threshold; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn's disease.
Topics: 3' Untranslated Regions; Adult; Animals; Base Sequence; Caco-2 Cells; Chemokine CCL20; Chemokines; Colitis; Crohn Disease; Down-Regulation; Female; HT29 Cells; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Intestinal Mucosa; Male; Mice; MicroRNAs; Middle Aged; Rats; Real-Time Polymerase Chain Reaction; RNA Interference; RNA, Messenger; RNA, Small Interfering; RNA, Untranslated; Sequence Alignment; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins; Trinitrobenzenesulfonic Acid | 2015 |
Investigation of the colon-targeting, improvement on the side-effects and therapy on the experimental colitis in mouse of a resin microcapsule loading dexamethasone sodium phosphate.
Topics: Acrylic Resins; Animals; Anion Exchange Resins; Capsules; Colitis; Colon; Dexamethasone; Drug Delivery Systems; Hydrogen-Ion Concentration; Mice; Rats; Trinitrobenzenesulfonic Acid | 2016 |
In Vivo Evaluation of 5-ASA Colon-Specific Tablets Using Experimental-Induced Colitis Rat Animal Model.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Female; Galactans; Male; Mannans; Mesalamine; Pectins; Plant Gums; Prodrugs; Rats; Tablets; Trinitrobenzenesulfonic Acid | 2015 |
Repression of Mammalian Target of Rapamycin Complex 1 Inhibits Intestinal Regeneration in Acute Inflammatory Bowel Disease Models.
Topics: Animals; Bone Marrow Transplantation; Caco-2 Cells; Cell Proliferation; Colitis; Gene Expression Regulation; Haploinsufficiency; Humans; Interleukin-6; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Neuropeptides; Ras Homolog Enriched in Brain Protein; Signal Transduction; Sirolimus; Sodium Dodecyl Sulfate; STAT3 Transcription Factor; Survival Analysis; TOR Serine-Threonine Kinases; Trinitrobenzenesulfonic Acid | 2015 |
SGK1 inhibits cellular apoptosis and promotes proliferation via the MEK/ERK/p53 pathway in colitis.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Colon; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; HCT116 Cells; Humans; Immediate-Early Proteins; Intestinal Mucosa; MAP Kinase Kinase 1; Mice, Inbred BALB C; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rabbits; RNA Interference; Signal Transduction; Time Factors; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Tumor Suppressor Protein p53 | 2015 |
Anti-inflammatory effects of ginsenoside Rg1 and its metabolites ginsenoside Rh1 and 20(S)-protopanaxatriol in mice with TNBS-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Ginsenosides; Interleukin-6; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; NF-kappa B; Peptidoglycan; Sapogenins; Th17 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Combined Therapy with Rheum tanguticum Polysaccharide and Low-dose 5-ASA Ameliorates TNBS-Induced Colitis in Rats by Suppression of NF-κB.
Topics: Animals; Body Weight; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Drug Therapy, Combination; Male; NF-kappa B; Nitric Oxide Synthase Type II; Polysaccharides; Rats; Rats, Sprague-Dawley; Rheum; Trinitrobenzenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Rivaroxaban Induces Mucosal Healing in a Rat Model of Trinitrobenzene Sulfonic Acid-Induced Colitis.
Topics: Animals; Colitis; Disease Models, Animal; Factor Xa Inhibitors; Female; Immunosuppressive Agents; Intestinal Mucosa; Malondialdehyde; Methylprednisolone; Rats; Rats, Wistar; Rivaroxaban; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Wound Healing | 2015 |
Experimental evidence of MAP kinase gene expression on the response of intestinal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Colitis; Enzyme Induction; Gene Expression; Male; Mitogen-Activated Protein Kinases; Prednisolone; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2015 |
Geraniol ameliorates TNBS-induced colitis: Involvement of Wnt/β-catenin, p38MAPK, NFκB, and PPARγ signaling pathways.
Topics: Acyclic Monoterpenes; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Drug Evaluation, Preclinical; Immunosuppressive Agents; Male; MAP Kinase Signaling System; NF-kappa B; PPAR gamma; Rats, Wistar; Terpenes; Trinitrobenzenesulfonic Acid; Wnt Signaling Pathway | 2015 |
The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils.
Topics: Animals; Antibodies, Monoclonal; Antigens, Differentiation, Myelomonocytic; Cell Movement; Colitis; Colon; Disease Models, Animal; Eosinophils; Female; Glutathione Transferase; Helminth Proteins; Immunization; Interleukin-13; Interleukin-5; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Schistosoma mansoni; Schistosomiasis mansoni; Sialic Acid Binding Immunoglobulin-like Lectins; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2016 |
Ocotillol, a Majonoside R2 Metabolite, Ameliorates 2,4,6-Trinitrobenzenesulfonic Acid-Induced Colitis in Mice by Restoring the Balance of Th17/Treg Cells.
Topics: Animals; Colitis; Ginsenosides; Humans; Interleukin-17; Interleukin-1beta; Mice; Panax; Plant Extracts; T-Lymphocytes, Regulatory; Th17 Cells; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Anti-inflammatory effects of Brazilian ginseng (Pfaffia paniculata) on TNBS-induced intestinal inflammation: Experimental evidence.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Glutathione; Male; Microscopy, Electron, Scanning; Panax; Peroxidase; Phytotherapy; Plant Extracts; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2015 |
Cape Gooseberry [Physalis peruviana L.] Calyces Ameliorate TNBS Acid-induced Colitis in Rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flowers; Mice; Mice, Inbred ICR; Physalis; Phytotherapy; Plant Extracts; Random Allocation; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2015 |
Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation.
Topics: Animals; Berberine; Cell Differentiation; Colitis; Colon; Inflammation; Macrophages; Male; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
The GPR55 antagonist CID16020046 protects against intestinal inflammation.
Topics: Animals; Azabicyclo Compounds; Benzoates; Cannabinoid Receptor Antagonists; Colitis; Dextran Sulfate; Male; Mice; Mice, Inbred C57BL; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Trinitrobenzenesulfonic Acid | 2015 |
Deficiency of Nuclear Receptor Nur77 Aggravates Mouse Experimental Colitis by Increased NFκB Activity in Macrophages.
Topics: Animals; Cell Line; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; Forkhead Transcription Factors; Gene Expression Regulation; Humans; Intestinal Mucosa; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 1; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Resveratrol Pretreatment Ameliorates TNBS Colitis in Rats.
Topics: Animals; Antioxidants; Colitis; Female; Inflammatory Bowel Diseases; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Resveratrol; Stilbenes; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2015 |
Behavioral despair associated with a mouse model of Crohn's disease: Role of nitric oxide pathway.
Topics: Animals; Antidepressive Agents; Colitis; Colon; Crohn Disease; Depression; Disease Models, Animal; Enzyme Inhibitors; Guanidines; Hippocampus; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitrites; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Biomarkers; Capsules; Chemistry, Pharmaceutical; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Gelatin; Gene Expression Regulation; HCT116 Cells; Humans; Inflammation Mediators; Male; Mice; Rats, Sprague-Dawley; RAW 264.7 Cells; Signal Transduction; Stilbenes; Technology, Pharmaceutical; Transfection; Trinitrobenzenesulfonic Acid | 2015 |
Endogenous BDNF augments NMDA receptor phosphorylation in the spinal cord via PLCγ, PKC, and PI3K/Akt pathways during colitis.
Topics: Animals; Antibodies; Brain-Derived Neurotrophic Factor; Chromones; Colitis; Disease Models, Animal; Enzyme Inhibitors; Male; Morpholines; Organ Culture Techniques; Phosphatidylinositol 3-Kinase; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Therapeutic and immunoregulatory effect of GATA-binding protein-3/T-box expressed in T-cells ratio of astragalus polysaccharides on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Astragalus Plant; Blotting, Western; Colitis; Colon; GATA3 Transcription Factor; Immunohistochemistry; Immunomodulation; Male; Peroxidase; Polysaccharides; Rats, Sprague-Dawley; T-Box Domain Proteins; Trinitrobenzenesulfonic Acid | 2016 |
Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Chromatography, High Pressure Liquid; Colitis; Colon; Cyclosporine; Cytokines; Disease Models, Animal; Half-Life; Humans; Leukocytes, Mononuclear; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Signal Transduction; STAT3 Transcription Factor; T-Lymphocytes; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid; Up-Regulation | 2015 |
Huangqin-Tang Ameliorates TNBS-Induced Colitis by Regulating Effector and Regulatory CD4(+) T Cells.
Topics: Animals; Colitis; Cytokines; Drugs, Chinese Herbal; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis.
Topics: Animals; Clodronic Acid; Colitis; Colonic Neoplasms; Cytokines; Dextran Sulfate; Disease Models, Animal; Flow Cytometry; Inflammation; Interleukin-10; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; N-Acetylglucosaminyltransferases; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2016 |
Dextran-5-(4-ethoxycarbonylphenylazo)salicylic acid ester, a polymeric colon-specific prodrug releasing 5-aminosalicylic acid and benzocaine, ameliorates TNBS-induced rat colitis.
Topics: Administration, Oral; Animals; Benzocaine; Cecum; Colitis; Colon; Dextrans; Inflammation Mediators; Male; Mesalamine; Polymers; Prodrugs; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2016 |
Neuroprotective Potential of Mesenchymal Stem Cell-Based Therapy in Acute Stages of TNBS-Induced Colitis in Guinea-Pigs.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Flow Cytometry; Guinea Pigs; Humans; Male; Mesenchymal Stem Cell Transplantation; Microscopy, Confocal; Myenteric Plexus; Neurons; Trinitrobenzenesulfonic Acid | 2015 |
Anti-inflammatory effect of dual nociceptin and opioid receptor agonist, BU08070, in experimental colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Buprenorphine; Cell Line; Colitis; Dose-Response Relationship, Drug; Humans; Male; Mice; Mice, Inbred BALB C; Nociceptin Receptor; Receptors, Opioid; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2015 |
Probiotic and anti-inflammatory attributes of an isolate Lactobacillus helveticus NS8 from Mongolian fermented koumiss.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Adhesion; Caco-2 Cells; Cells, Cultured; Colitis; Cultured Milk Products; Disease Models, Animal; Gastrointestinal Tract; Humans; Interleukin-10; Lactobacillus helveticus; Leukocytes, Mononuclear; Membrane Glycoproteins; Mice; Molecular Typing; Mongolia; Probiotics; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Experimental evidence of heparanase, Hsp70 and NF-κB gene expression on the response of anti-inflammatory drugs in TNBS-induced colonic inflammation.
Topics: Animals; Anti-Inflammatory Agents; Azathioprine; Biomarkers; Colitis; Colon; Cytokines; Gene Expression; Glucuronidase; HSP70 Heat-Shock Proteins; Inflammatory Bowel Diseases; Male; NF-kappa B; Prednisolone; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2015 |
Activation of colo-rectal high-threshold afferent nerves by Interleukin-2 is tetrodotoxin-sensitive and upregulated in a mouse model of chronic visceral hypersensitivity.
Topics: Adaptive Immunity; Afferent Pathways; Animals; Colitis; Disease Models, Animal; Ganglia, Spinal; Hyperalgesia; Interleukin-2; Irritable Bowel Syndrome; Mice; NAV1.7 Voltage-Gated Sodium Channel; Neurons, Afferent; Peroxidase; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sodium Channel Blockers; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Visceral Pain | 2016 |
Interleukin 19 reduces inflammation in chemically induced experimental colitis.
Topics: Animals; Colitis; Crohn Disease; Cytokines; Inflammation; Interleukin-10; Interleukins; Mice; Mice, Inbred C57BL; Mice, Knockout; Recovery of Function; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2015 |
The gut microbiome as a target for regulatory T cell-based immunotherapy: induction of regulatory lymphocytes by oral administration of anti-LPS enriched colostrum alleviates immune mediated colitis.
Topics: Administration, Oral; Animals; Cattle; Colitis; Colostrum; Cytokines; Female; Gastrointestinal Microbiome; Immunoglobulin G; Immunotherapy; Inflammation; Interleukin-10; Lipopolysaccharides; Mice; Pregnancy; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Weight Loss | 2015 |
Ethyl pyruvate ameliorates experimental colitis in mice by inhibiting the HMGB1-Th17 and Th1/Tc1 responses.
Topics: Animals; Cell Line, Tumor; Colitis; Female; HMGB1 Protein; Lipopolysaccharides; Lymph Nodes; Mice; Mice, Inbred BALB C; Pyruvates; Spleen; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2015 |
Actions of probiotics on trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Colitis; Enteric Nervous System; Enterococcus faecalis; Gastrointestinal Motility; Male; Probiotics; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2015 |
Mycophenolate Mofetil Modulates Differentiation of Th1/Th2 and the Secretion of Cytokines in an Active Crohn's Disease Mouse Model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Colitis; Crohn Disease; Disease Models, Animal; Female; Gene Expression; Immunosuppressive Agents; Interferon-gamma; Interleukin-12; Interleukin-1beta; Interleukin-6; Mice; Mice, Inbred BALB C; Mycophenolic Acid; Spleen; Th1 Cells; Th1-Th2 Balance; Th2 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2015 |
Elevated H2 O2 levels in trinitrobenzene sulfate-induced colitis rats contributes to visceral hyperalgesia through interaction with the transient receptor potential ankyrin 1 cation channel.
Topics: Abdominal Pain; Acetanilides; Acetylcysteine; Administration, Intravenous; Animals; Colitis; Colon; Disease Models, Animal; Free Radical Scavengers; Hydrogen Peroxide; Hyperalgesia; Male; Pain Threshold; Purines; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Up-Regulation; Visceral Pain | 2016 |
The activation of Wnt signaling by a STAT6-dependent macrophage phenotype promotes mucosal repair in murine IBD.
Topics: Animals; Cell Differentiation; Cells, Cultured; Colitis; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, Knockout; Phenotype; Signal Transduction; STAT6 Transcription Factor; Trinitrobenzenesulfonic Acid; Wnt Proteins; Wound Healing | 2016 |
Anti-fibrotic effects of a novel small compound on the regulation of cytokine production in a mouse model of colorectal fibrosis.
Topics: Alkadienes; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Female; Fibrosis; Mice; Mice, Inbred BALB C; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2015 |
Noninflammatory upregulation of nerve growth factor underlies gastric hypersensitivity induced by neonatal colon inflammation.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Abdominal Pain; Adrenergic Antagonists; Age Factors; Animals; Animals, Newborn; Carrier Proteins; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Colon; Disease Models, Animal; Gastric Fundus; Intracellular Signaling Peptides and Proteins; Male; Matrix Metalloproteinase 9; Nerve Growth Factor; Norepinephrine; Phosphoproteins; Phosphorylation; Protein Kinase Inhibitors; Protein Stability; Proteolysis; Proto-Oncogene Proteins c-akt; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Combining selected immunomodulatory Propionibacterium freudenreichii and Lactobacillus delbrueckii strains: Reverse engineering development of an anti-inflammatory cheese.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers; Body Weight; Cheese; Colitis; Colon; Female; Fermentation; Gastrointestinal Microbiome; Lactobacillus delbrueckii; Mice, Inbred BALB C; Oxidative Stress; Probiotics; Propionibacterium freudenreichii; Trinitrobenzenesulfonic Acid | 2016 |
Histamine H2 Receptor-Mediated Suppression of Intestinal Inflammation by Probiotic Lactobacillus reuteri.
Topics: Animals; Colitis; Colon; Diet; Disease Models, Animal; Gastrointestinal Microbiome; Histamine; Histidine; Histidine Decarboxylase; Immunomodulation; Interleukin-1beta; Interleukin-6; Intestinal Mucosa; Limosilactobacillus reuteri; Mice; Positron-Emission Tomography; Probiotics; Receptors, Histamine H2; Serum Amyloid A Protein; Signal Transduction; Trinitrobenzenesulfonic Acid | 2015 |
Novel anti-inflammatory agent 3-[(dodecylthiocarbonyl)-methyl]-glutarimide ameliorates murine models of inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; CD4-Positive T-Lymphocytes; Cell Line; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peroxidase; Piperidones; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2016 |
Colitis-induced bladder afferent neuronal activation is regulated by BDNF through PLCγ pathway.
Topics: Animals; Brain-Derived Neurotrophic Factor; Colitis; CREB-Binding Protein; Disease Models, Animal; Ganglia, Spinal; Male; Mice, Knockout; Neurons; Phospholipase C gamma; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; Up-Regulation; Urinary Bladder | 2016 |
Allogeneic guinea pig mesenchymal stem cells ameliorate neurological changes in experimental colitis.
Topics: Adipose Tissue; Animals; Bone Marrow Cells; Cell Differentiation; Cholinergic Neurons; Colitis; Disease Models, Animal; Female; Guinea Pigs; Humans; Hyaluronan Receptors; Immunohistochemistry; Immunophenotyping; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Microscopy, Confocal; Myenteric Plexus; Transforming Growth Factor beta1; Transplantation, Homologous; Trinitrobenzenesulfonic Acid | 2015 |
Oridonin derivative ameliorates experimental colitis by inhibiting activated T-cells and translocation of nuclear factor-kappa B.
Topics: Alanine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cytokines; Disease Models, Animal; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Gastrointestinal Agents; Immunosuppressive Agents; Inflammation Mediators; Intestinal Mucosa; Lymphocyte Activation; Male; Mice, Inbred BALB C; NF-kappa B; Signal Transduction; Spleen; T-Lymphocyte Subsets; Th1 Cells; Th17 Cells; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2016 |
1,25-hydroxyvitamin D relieves colitis in rats via down-regulation of toll-like receptor 9 expression.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Inflammation; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Severity of Illness Index; Toll-Like Receptor 9; Trinitrobenzenesulfonic Acid; Vitamin D | 2015 |
Therapeutic potential of recombinant cystatin from Schistosoma japonicum in TNBS-induced experimental colitis of mice.
Topics: Animals; Colitis; Colon; Cystatins; Cytokines; Female; Gene Expression Regulation; Inflammation; Intestinal Mucosa; Mice, Inbred BALB C; Recombinant Proteins; Schistosoma japonicum; Spleen; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2016 |
Does oral exposure to cadmium and lead mediate susceptibility to colitis? The dark-and-bright sides of heavy metals in gut ecology.
Topics: Administration, Oral; Animals; Cadmium; Colitis; Dextran Sulfate; Disease Models, Animal; Disease Susceptibility; Female; Immune System; Immunomodulation; Intestinal Mucosa; Lead; Metals, Heavy; Mice; Salmonella Infections; Salmonella typhimurium; Time Factors; Trinitrobenzenesulfonic Acid | 2016 |
Gender-related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.
Topics: Animals; Colitis; Colon; Dipeptides; Disease Models, Animal; Female; Guinea Pigs; Hyperalgesia; Male; Receptors, Neurokinin-2; Sex Characteristics; Thiophenes; Trinitrobenzenesulfonic Acid; Visceral Pain | 2016 |
Intestinal anti-inflammatory activity of calcium pyruvate in the TNBS model of rat colitis: Comparison with ethyl pyruvate.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Female; Gene Expression; Inflammation Mediators; Intestinal Mucosa; Neutrophil Infiltration; NF-kappa B; Phosphorylation; Pyruvates; Pyruvic Acid; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2016 |
Mechanism of action and efficacy of RX-111, a thieno[2,3-c]pyridine derivative and small molecule inhibitor of protein interaction with glycosaminoglycans (SMIGs), in delayed-type hypersensitivity, TNBS-induced colitis and experimental autoimmune encephal
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Colitis; Encephalomyelitis, Autoimmune, Experimental; Heparitin Sulfate; Human Umbilical Vein Endothelial Cells; Humans; Hypersensitivity, Delayed; Leukocyte Rolling; Male; Mice, Inbred BALB C; Myelin Basic Protein; Oxazolone; Pyridines; Rats; Rats, Inbred Lew; T-Lymphocytes; Thiophenes; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2016 |
Raf kinase inhibitor protein mediates intestinal epithelial cell apoptosis and promotes IBDs in humans and mice.
Topics: Animals; Apoptosis; Colitis; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Epithelial Cells; HCT116 Cells; Homeostasis; Humans; Intestinal Mucosa; MAP Kinase Kinase Kinases; Mice; Mice, Knockout; Phosphatidylethanolamine Binding Protein; Phosphorylation; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2017 |
MicroRNA-124 Promotes Intestinal Inflammation by Targeting Aryl Hydrocarbon Receptor in Crohn's Disease.
Topics: Adolescent; Adult; Aged; Animals; Basic Helix-Loop-Helix Transcription Factors; Biomarkers; Caco-2 Cells; Colitis; Colon; Crohn Disease; Cytokines; Down-Regulation; Female; HT29 Cells; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Middle Aged; Real-Time Polymerase Chain Reaction; Receptors, Aryl Hydrocarbon; Trinitrobenzenesulfonic Acid; Up-Regulation; Young Adult | 2016 |
E3 Ubiquitin ligase RNF183 Is a Novel Regulator in Inflammatory Bowel Disease.
Topics: Adolescent; Adult; Aged; Animals; Biomarkers; Blotting, Western; Case-Control Studies; Colitis; Colon; Crohn Disease; Female; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; MicroRNAs; Middle Aged; NF-kappa B; NF-KappaB Inhibitor alpha; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Ubiquitin-Protein Ligases; Up-Regulation; Young Adult | 2016 |
Chlorogenic acid ameliorates intestinal mitochondrial injury by increasing antioxidant effects and activity of respiratory complexes.
Topics: Animals; Antioxidants; Chlorogenic Acid; Colitis; Cytochromes c; Electron Transport Complex I; Electron Transport Complex IV; Enzyme Activation; Female; Glutathione; Hydrogen Peroxide; Membrane Potential, Mitochondrial; Mitochondria; Mitochondrial Swelling; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2016 |
Melatonin, but not melatonin receptor agonists Neu-P11 and Neu-P67, attenuates TNBS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Indoles; Male; Melatonin; Mice, Inbred BALB C; Peroxidase; Pyrans; Receptors, Melatonin; Trinitrobenzenesulfonic Acid | 2016 |
Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Colon; Cyclooxygenase 2; Extracellular Signal-Regulated MAP Kinases; Forkhead Transcription Factors; Glucosides; Interleukin-10; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; Peroxidase; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Xanthones | 2016 |
[Regulatory effect of curcumin on subsets and co-stimulatory molecules of dendritic cells in spleen from mice with colitis].
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, CD; Cells, Cultured; Colitis; Colon; Curcumin; Dendritic Cells; Flow Cytometry; Histocompatibility Antigens Class II; Male; Mice, Inbred C57BL; Random Allocation; Spleen; Toll-Like Receptor 2; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
Eosinophils Contribute to Intestinal Inflammation via Chemoattractant Receptor-homologous Molecule Expressed on Th2 Cells, CRTH2, in Experimental Crohn's Disease.
Topics: Adult; Aged; Animals; Biomarkers; Blotting, Western; Case-Control Studies; Colitis; Colon; Crohn Disease; Cytokines; Eosinophils; Female; Flow Cytometry; Humans; Immunoassay; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Knockout; Middle Aged; Receptors, Immunologic; Receptors, Prostaglandin; Th2 Cells; Trinitrobenzenesulfonic Acid | 2016 |
The flesh ethanolic extract of Hylocereus polyrhizus exerts anti-inflammatory effects and prevents murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Cactaceae; Colitis; Colon; Cytokines; Disease Models, Animal; Ethanol; Flavonoids; Fruit; Gene Expression; Irritable Bowel Syndrome; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Extracts; Polyphenols; Trinitrobenzenesulfonic Acid | 2016 |
Cholecalciterol cholesterol emulsion ameliorates experimental colitis via down-regulating the pyroptosis signaling pathway.
Topics: Animals; Blotting, Western; Calcitriol; Calcium; Caspase 1; Child; Child, Preschool; Cholecalciferol; Cholesterol; Colitis; Colon; Emulsions; Female; Gene Expression; Humans; Interleukin-18; Interleukin-1beta; Male; Mice, Inbred BALB C; Phosphorus; Pyroptosis; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Survival Rate; Trinitrobenzenesulfonic Acid; Vitamin D Deficiency; Vitamins | 2016 |
Mangiferin corrects the imbalance of Th17/Treg cells in mice with TNBS-induced colitis.
Topics: Anemarrhena; Animals; Cell Differentiation; Cells, Cultured; Colitis; Coptis chinensis; Drugs, Chinese Herbal; Forkhead Transcription Factors; Homeostasis; Humans; Interleukin-10; Interleukin-17; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Nuclear Receptor Subfamily 1, Group F, Member 3; T-Lymphocytes, Regulatory; Th17 Cells; Trinitrobenzenesulfonic Acid; Xanthones | 2016 |
Experimental and Pathalogical study of Pistacia atlantica, butyrate, Lactobacillus casei and their combination on rat ulcerative colitis model.
Topics: Animals; Butyrates; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Lacticaseibacillus casei; Male; Oxidative Stress; Peroxidase; Pistacia; Plant Extracts; Probiotics; Rats; Rats, Wistar; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2016 |
Methods of Inducing Inflammatory Bowel Disease in Mice.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Inflammation; Inflammatory Bowel Diseases; Interleukin-10; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Trinitrobenzenes; Trinitrobenzenesulfonic Acid | 2016 |
Up regulation of glyoxylate reductase/hydroxypyruvate reductase (GRHPR) is associated with intestinal epithelial cells apoptosis in TNBS-induced experimental colitis.
Topics: Alcohol Oxidoreductases; Animals; Apoptosis; Caspase 3; Cell Line, Tumor; Colitis; Disease Models, Animal; Epithelial Cells; Humans; Intestinal Mucosa; Intestines; Mice; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Astragalus polysaccharide attenuates rat experimental colitis by inducing regulatory T cells in intestinal Peyer's patches.
Topics: Animals; Anti-Inflammatory Agents; Astragalus propinquus; Colitis; Colon; Cytokines; Disease Models, Animal; Inflammation Mediators; Male; Nuclear Receptor Subfamily 1, Group F, Member 3; Peyer's Patches; Phosphorylation; Phytotherapy; Plants, Medicinal; Polysaccharides; Rats, Sprague-Dawley; STAT5 Transcription Factor; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2016 |
Goniothalamin prevents the development of chemically induced and spontaneous colitis in rodents and induces apoptosis in the HT-29 human colon tumor cell line.
Topics: Animals; Apoptosis; Caspases; Cell Cycle; Cell Line, Tumor; Colitis; Colonic Neoplasms; Down-Regulation; HT29 Cells; Humans; Interleukin-10; Leukocytes; Male; Mice, Inbred C57BL; Peroxidase; Pyrones; Rats; Rats, Wistar; Sirtuin 1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2016 |
Atorvastatin attenuates TNBS-induced rat colitis: the involvement of the TLR4/NF-kB signaling pathway.
Topics: Animals; Atorvastatin; Colitis; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; NF-kappa B; Random Allocation; Rats; Rats, Wistar; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
Insight into the pharmacokinetic behavior of tanshinone IIA in the treatment of Crohn's disease: comparative data for tanshinone IIA and its two glucuronidated metabolites in normal and recurrent colitis models after oral administration.
Topics: Abietanes; Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Crohn Disease; Disease Models, Animal; Glucuronosyltransferase; Mice; Trinitrobenzenesulfonic Acid; UDP-Glucuronosyltransferase 1A9 | 2017 |
Lactobacillus rhamnosus RC007 intended for feed additive: immune-stimulatory properties and ameliorating effects on TNBS-induced colitis.
Topics: Animal Feed; Animals; Body Weight; Colitis; Cytokines; Female; Intestines; Lacticaseibacillus rhamnosus; Mice, Inbred BALB C; Microbiota; Phagocytosis; Probiotics; Trinitrobenzenesulfonic Acid | 2016 |
Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response.
Topics: Animals; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Forkhead Transcription Factors; Hot Temperature; Humans; Immunosuppression Therapy; Immunotherapy; Inflammation Mediators; Intestinal Mucosa; Lacticaseibacillus casei; Male; Mice; Mice, Inbred BALB C; Probiotics; T-Lymphocytes, Regulatory; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid | 2016 |
Comparison of Adipose-Derived and Bone Marrow Mesenchymal Stromal Cells in a Murine Model of Crohn's Disease.
Topics: Adipose Tissue; Animals; Bone Marrow Cells; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Flow Cytometry; Immunohistochemistry; Injections, Intraperitoneal; Interleukin-10; Interleukin-12; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Real-Time Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2017 |
5-Aminosalicylic Acid Azo-Linked to Procainamide Acts as an Anticolitic Mutual Prodrug via Additive Inhibition of Nuclear Factor kappaB.
Topics: Animals; Azo Compounds; Colitis; Colon; Male; Mesalamine; NF-kappa B; Procainamide; Prodrugs; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2016 |
Anti-inflammatory effects of Citrus sinensis L., Citrus paradisi L. and their combinations.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; C-Reactive Protein; Citrus paradisi; Citrus sinensis; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fruit; Fruit and Vegetable Juices; Glutathione; Inflammation Mediators; Male; Oxidative Stress; Peroxidase; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2016 |
Poncirin and its metabolite ponciretin attenuate colitis in mice by inhibiting LPS binding on TLR4 of macrophages and correcting Th17/Treg imbalance.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Bacteria; Biotransformation; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Flavonoids; Gastrointestinal Agents; Gastrointestinal Microbiome; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Male; Mice, Inbred C57BL; NF-kappa B; Signal Transduction; Spleen; T-Lymphocytes, Regulatory; Th17 Cells; Time Factors; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
The suppressor of cytokine signaling SOCS1 promotes apoptosis of intestinal epithelial cells via p53 signaling in Crohn's disease.
Topics: Animals; Apoptosis; Colitis; Crohn Disease; Epithelial Cells; Female; Gene Knockdown Techniques; HT29 Cells; Humans; Interferon-gamma; Intestines; Mice, Inbred BALB C; Signal Transduction; Suppressor of Cytokine Signaling 1 Protein; Trinitrobenzenesulfonic Acid; Tumor Suppressor Protein p53 | 2016 |
Murine Trinitrobenzoic Acid-Induced Colitis as a Model of Crohn's Disease.
Topics: Adaptive Immunity; Animals; Colitis; Crohn Disease; Disease Models, Animal; Gastrointestinal Microbiome; Humans; Immunity, Innate; Mice; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2016 |
VBP15, a novel dissociative steroid compound, reduces NFκB-induced expression of inflammatory cytokines in vitro and symptoms of murine trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Body Size; Cells, Cultured; Colitis; Cytokines; Disease Models, Animal; Epithelial Cells; Female; Humans; Male; Mice, Inbred BALB C; NF-kappa B; Pregnadienediols; Trinitrobenzenesulfonic Acid | 2016 |
Anti-inflammatory activity of hydroalcoholic extracts of Lavandula dentata L. and Lavandula stoechas L.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Cell Line; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Colitis; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Edema; Female; Glutathione; Inflammation Mediators; Lavandula; Matrix Metalloproteinase 9; Methanol; Mice, Inbred BALB C; Neutrophil Infiltration; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Phytotherapy; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Rats, Wistar; Solvents; Trinitrobenzenesulfonic Acid | 2016 |
Isomeranzin suppresses inflammation by inhibiting M1 macrophage polarization through the NF-κB and ERK pathway.
Topics: Animals; Anti-Inflammatory Agents; Cell Differentiation; Colitis; Coumarins; Dextran Sulfate; Extracellular Signal-Regulated MAP Kinases; Female; Macrophages; Mice; Mice, Inbred C57BL; Murraya; NF-kappa B; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2016 |
Structural and molecular features of intestinal strictures in rats with Crohn's-like disease.
Topics: Animals; Apoptosis; Blotting, Western; Colitis; Colon; Constriction, Pathologic; Crohn Disease; Disease Models, Animal; Gene Expression Regulation; Immunohistochemistry; Intestinal Obstruction; Male; Matrix Metalloproteinase 9; Microscopy, Electron, Transmission; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tissue Inhibitor of Metalloproteinase-1; Transforming Growth Factor beta2; Transforming Growth Factor beta3; Trinitrobenzenesulfonic Acid | 2016 |
FolC2-mediated folate metabolism contributes to suppression of inflammation by probiotic Lactobacillus reuteri.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Female; Gastrointestinal Microbiome; Humans; Inflammation; Limosilactobacillus reuteri; Mice; Mice, Inbred BALB C; Multienzyme Complexes; Mutagenesis, Insertional; Peptide Synthases; Probiotics; Tetrahydrofolates; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Effects of AP‑1 and NF‑κB inhibitors on colonic endocrine cells in rats with TNBS‑induced colitis.
Topics: Animals; Benzamides; Biomarkers; Body Weight; Chromogranin A; Colitis; Cyclohexanones; Disease Models, Animal; Endocrine Cells; Gene Expression; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; NF-kappa B; Piperidones; Rats; Serotonin; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2016 |
Transplantation of a bacterial consortium ameliorates trinitrobenzenesulfonic acid-induced colitis and intestinal dysbiosis in rats.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Dysbiosis; Fecal Microbiota Transplantation; Feces; Gastrointestinal Microbiome; Inflammatory Bowel Diseases; Intestines; Mice; Microbial Consortia; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2016 |
Effect of a probiotic Lactobacillus plantarum TN8 strain on trinitrobenzene sulphonic acid-induced colitis in rats.
Topics: Animals; Colitis; Diarrhea; Inflammation; Lactobacillus plantarum; Male; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2017 |
Andrographolide derivative AL-1 ameliorates TNBS-induced colitis in mice: involvement of NF-кB and PPAR-γ signaling pathways.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Diterpenes; Inflammation Mediators; Mice, Inbred C57BL; NF-kappa B; Peroxidase; PPAR gamma; Signal Transduction; Thioctic Acid; Trinitrobenzenesulfonic Acid | 2016 |
Antiinflammatory and immunomodulatory activity of an ethanolic extract from the stem bark of Terminalia catappa L. (Combretaceae): In vitro and in vivo evidences.
Topics: Animals; Anti-Inflammatory Agents; Chromatography, High Pressure Liquid; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Female; Immunologic Factors; Inflammation Mediators; Macrophages; Mass Spectrometry; Mice; Microfilament Proteins; Mucins; Nitric Oxide Synthase Type II; Nitrites; Phenols; Phytotherapy; Plant Bark; Plant Extracts; Plants, Medicinal; Rats, Wistar; RAW 264.7 Cells; Solvents; Terminalia; Trinitrobenzenesulfonic Acid | 2016 |
Highly specific blockade of CCR5 inhibits leukocyte trafficking and reduces mucosal inflammation in murine colitis.
Topics: Animals; CD11b Antigen; CD4-Positive T-Lymphocytes; Chemokine CCL5; Chemokines; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Homeodomain Proteins; Inflammation; Intestinal Mucosa; Leukocytes; Maraviroc; Mice; Mice, Inbred C57BL; Mice, Knockout; Th17 Cells; Triazoles; Trinitrobenzenesulfonic Acid; Up-Regulation | 2016 |
Enhanced effect of κ-carrageenan on TNBS-induced inflammation in mice.
Topics: Animals; Carrageenan; CD4-Positive T-Lymphocytes; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Female; Humans; Male; Mice; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2016 |
Effects of mimic of manganese superoxide dismutase on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Body Weight; Colitis; Colon; Male; Molecular Mimicry; Rats; Rats, Wistar; Superoxide Dismutase; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2016 |
Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5(+) B regulatory cells.
Topics: Animals; CD5 Antigens; Cell Proliferation; Colitis; Disease Models, Animal; Humans; Inflammation; Interleukin-10; Male; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Stem Cells; Survival Rate; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2016 |
The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca(2+)-NOS pathway.
Topics: Analgesics; Animals; Calcium; Cell Degranulation; Cell Line; Colitis; Colon; Evoked Potentials; Histamine Release; Humans; Male; Mast Cells; Microscopy, Confocal; Nitric Oxide Synthase; omega-N-Methylarginine; Oxytocin; Patch-Clamp Techniques; Rats; Rats, Wistar; Receptors, Oxytocin; Signal Transduction; Trinitrobenzenesulfonic Acid; Vasotocin | 2016 |
Investigation of pulmonary involvement in inflammatory bowel disease in an experimental model of colitis.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Lung; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2016 |
Protective effect of curcumin on TNBS-induced intestinal inflammation is mediated through the JAK/STAT pathway.
Topics: Animals; Apoptosis; Colitis; Colon; Curcumin; Janus Kinases; Macrophages; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; STAT Transcription Factors; Trinitrobenzenesulfonic Acid | 2016 |
Adeno-associated virus-mediated colonic secretory expression of HMGB1 A box attenuates experimental colitis in mice.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Colon; Cytokines; Dependovirus; Dextran Sulfate; Epithelial Cells; HMGB1 Protein; Humans; Male; Mice, Inbred BALB C; Peroxidase; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2016 |
Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.
Topics: Animals; Anti-Inflammatory Agents; Biomarkers; Colitis; Colon; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Epoetin Alfa; Inflammation Mediators; Male; Mice; Peroxidase; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2017 |
Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fatty Acids, Volatile; Galactans; Gastrointestinal Microbiome; Hydrolysis; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestines; Male; Mannans; Mice; Mice, Inbred C57BL; Peroxidase; Plant Gums; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2016 |
Rectal Delivery of a DNAzyme That Specifically Blocks the Transcription Factor GATA3 and Reduces Colitis in Mice.
Topics: Administration, Rectal; Adolescent; Adult; Aged; Animals; Case-Control Studies; Child; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Cytokines; Disease Models, Animal; DNA, Catalytic; Female; GATA3 Transcription Factor; Humans; Intestinal Mucosa; Male; Mice; Mice, Knockout; Middle Aged; Oxazolone; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; RNA, Messenger; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Young Adult | 2017 |
TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Humans; Immune Tolerance; Jagged-1 Protein; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, SCID; Poly I-C; Receptor, Notch1; Signal Transduction; T-Lymphocytes, Regulatory; Toll-Like Receptor 3; Transplantation Conditioning; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2017 |
Synthesis and evaluation of anti-inflammatory properties of silver nanoparticle suspensions in experimental colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Clostridium perfringens; Colitis; Colony Count, Microbial; Escherichia coli; Lactobacillus; Male; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Silver; Trinitrobenzenesulfonic Acid | 2017 |
NOX1/NADPH Oxidase Expressed in Colonic Macrophages Contributes to the Pathogenesis of Colonic Inflammation in Trinitrobenzene Sulfonic Acid-Induced Murine Colitis.
Topics: Animals; Body Weight; Colitis; Colon; Diarrhea; Gene Expression Regulation, Enzymologic; Gene Knockout Techniques; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; Peroxidase; RAW 264.7 Cells; Reactive Oxygen Species; RNA, Messenger; Trinitrobenzenesulfonic Acid; Up-Regulation | 2017 |
The Bisphosphonate Pamidronate is an Intestinal Antiinflammatory Agent in Rat and Mouse Experimental Colitis.
Topics: Alendronate; Animals; Anti-Inflammatory Agents; Colitis; Dextran Sulfate; Diphosphonates; Ibandronic Acid; Immunologic Factors; Intestinal Mucosa; Mice; Pamidronate; Rats; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2016 |
Goat whey ameliorates intestinal inflammation on acetic acid-induced colitis in rats.
Topics: Acetic Acid; Animals; Colitis; Colon; Goats; Humans; Inflammation; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Whey | 2016 |
Enteroendocrine cells, stem cells and differentiation progenitors in rats with TNBS-induced colitis.
Topics: Animals; Biomarkers; Cell Differentiation; Colitis; Disease Models, Animal; Enteroendocrine Cells; Immunohistochemistry; Inflammatory Bowel Diseases; Male; Rats; Stem Cells; Trinitrobenzenesulfonic Acid | 2016 |
AHR Activation Is Protective against Colitis Driven by T Cells in Humanized Mice.
Topics: Animals; Colitis; Disease Models, Animal; Forkhead Transcription Factors; Humans; Mice; Receptors, Aryl Hydrocarbon; T-Lymphocytes, Regulatory; Thiazoles; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2016 |
Imiquimod-induced CCR9 Ameliorates murine TNBS Colitis.
Topics: Aminoquinolines; Animals; Cell Differentiation; Cells, Cultured; Colitis; Female; Imiquimod; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Receptors, CCR; T-Lymphocytes, Regulatory; Toll-Like Receptor 7; Trinitrobenzenesulfonic Acid | 2016 |
Changes in enteroendocrine and immune cells following colitis induction by TNBS in rats.
Topics: Animals; Biopsy; Colitis; Colonoscopy; Disease Models, Animal; Endocrine Cells; Intestinal Mucosa; Lymphocytes; Macrophages; Male; Monocytes; Rats; Trinitrobenzenesulfonic Acid | 2016 |
Application of carbon nanotubes as the carriers of the cannabinoid, 2-arachidonoylglycerol: Towards a novel treatment strategy in colitis.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Colitis; Disease Models, Animal; Drug Delivery Systems; Endocannabinoids; Glycerides; Inflammation; Male; Microscopy, Electron, Transmission; Nanotubes, Carbon; Oxidative Stress; Rats; Rats, Wistar; Spectroscopy, Fourier Transform Infrared; Trinitrobenzenesulfonic Acid | 2017 |
Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation.
Topics: Animals; CD3 Complex; CD4 Lymphocyte Count; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dextran Sulfate; Drugs, Chinese Herbal; Female; Forkhead Transcription Factors; Gene Expression; Indigo Carmine; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Interleukin-22; Interleukins; Intestinal Mucosa; Leukocytes, Mononuclear; Mice, Knockout; Nuclear Receptor Subfamily 1, Group F, Member 3; Receptors, Aryl Hydrocarbon; RNA, Messenger; Severity of Illness Index; Spleen; T-Lymphocytes; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2017 |
The signaling axis of microRNA-31/interleukin-25 regulates Th1/Th17-mediated inflammation response in colitis.
Topics: 3' Untranslated Regions; Adolescent; Adult; Animals; Antibodies, Blocking; Colitis; Crohn Disease; Disease Models, Animal; Female; Humans; Inflammation; Interleukin-10; Interleukin-17; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Knockout; MicroRNAs; Middle Aged; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Young Adult | 2017 |
High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice.
Topics: Animals; Colitis; Diet; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-17; Intestinal Mucosa; Male; Mice; Mucosal-Associated Invariant T Cells; Sodium, Dietary; T-Lymphocytes, Regulatory; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo.
Topics: ADAM10 Protein; ADAM17 Protein; Animals; Arthritis; Cells, Cultured; Colitis; Collagen; Disease Models, Animal; Drug Evaluation, Preclinical; Enzyme Inhibitors; HEK293 Cells; Humans; Lipopolysaccharides; Macrophages; Mice; Protein Domains; Shock, Septic; Trinitrobenzenesulfonic Acid | 2016 |
Monitoring of Chemically Induced Colitis.
Topics: Animals; Antigens, CD; Antigens, Differentiation; Biomarkers; Body Weight; Colitis; Colonoscopy; Cytokines; Disease Models, Animal; Gene Expression; Humans; Immunity, Mucosal; Immunohistochemistry; Mice; Mucous Membrane; Peroxidase; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2017 |
Sijunzi Decoction attenuates 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats and ameliorates TNBS-induced claudin-2 damage via NF-κB pathway in Caco2 cells.
Topics: Animals; Caco-2 Cells; Claudin-2; Colitis; Drugs, Chinese Herbal; Humans; Intestinal Mucosa; Male; NF-kappa B; Rats; Signal Transduction; Trinitrobenzenesulfonic Acid | 2017 |
Glycyrrhizin ameliorates experimental colitis through attenuating interleukin-17-producing T cell responses via regulating antigen-presenting cells.
Topics: Animals; Anti-Inflammatory Agents; Cell Proliferation; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Glycyrrhiza; Glycyrrhizic Acid; HMGB1 Protein; Humans; Inflammation Mediators; Lymphocyte Activation; Macrophages; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred BALB C; Th17 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Anti-inflammatory effects of Dioscorea alata L. anthocyanins in a TNBS-induced colitis model.
Topics: Animals; Anthocyanins; Anti-Inflammatory Agents; Colitis; Cytokines; Dioscorea; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Trinitrobenzenesulfonic Acid | 2017 |
SPECT-computed tomography in rats with TNBS-induced colitis: A first step toward functional imaging.
Topics: Animals; Blotting, Western; Citrates; Colitis; Colon; Crohn Disease; Cyclooxygenase 2; Disease Models, Animal; Feasibility Studies; Gallium; Male; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Tomography, Emission-Computed, Single-Photon; Trinitrobenzenesulfonic Acid | 2017 |
Astragaloside IV ameliorates 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis implicating regulation of energy metabolism.
Topics: Actins; Animals; Biomarkers; Cell Count; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Energy Metabolism; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Proteolysis; Rats; Regional Blood Flow; Saponins; Stem Cells; Tight Junction Proteins; Trinitrobenzenesulfonic Acid; Triterpenes | 2017 |
Therapeutic efficacy of carboxyamidotriazole on 2,4,6-trinitrobenzene sulfonic acid-induced colitis model is associated with the inhibition of NLRP3 inflammasome and NF-κB activation.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Female; Gene Expression Regulation; Humans; Inflammasomes; Inflammatory Bowel Diseases; Intestines; NF-kappa B; NLR Family, Pyrin Domain-Containing 3 Protein; Rats; Rats, Sprague-Dawley; Signal Transduction; Triazoles; Trinitrobenzenesulfonic Acid | 2017 |
Local enema treatment to inhibit FOLH1/GCPII as a novel therapy for inflammatory bowel disease.
Topics: Animals; Colitis; Colon; Enema; Glutamate Carboxypeptidase II; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice, Inbred BALB C; Organophosphorus Compounds; Trinitrobenzenesulfonic Acid | 2017 |
Investigating the potential of Tamarindus indica pectin-chitosan conjugate for reducing recovery period in TNBS induced colitis.
Topics: Animals; Chitosan; Colitis; Disease Models, Animal; Drug Delivery Systems; Humans; Pectins; Plant Exudates; Rats; Tablets; Tamarindus; Trinitrobenzenesulfonic Acid; Wound Healing | 2017 |
Microtubule-associated protein 1S-related autophagy inhibits apoptosis of intestinal epithelial cells via Wnt/β-catenin signaling in Crohn's disease.
Topics: Animals; Apoptosis; Autophagy; Benzothiazoles; Blotting, Western; Caspase 3; Cells, Cultured; Colitis; Crohn Disease; Epithelial Cells; HCT116 Cells; Humans; Immunohistochemistry; Intestinal Mucosa; Mice; Microscopy, Confocal; Microtubule-Associated Proteins; RNA Interference; Trinitrobenzenesulfonic Acid; Wnt Signaling Pathway | 2017 |
4-Methoxylonchocarpin attenuates inflammation by inhibiting lipopolysaccharide binding to Toll-like receptor of macrophages and M1 macrophage polarization.
Topics: Abrus; Animals; Anti-Inflammatory Agents; Cell Differentiation; Cells, Cultured; Colitis; Colon; Flavones; Inflammation; Interleukin-6; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred ICR; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2017 |
Exploration of Inflammatory Bowel Disease in Mice: Chemically Induced Murine Models of Inflammatory Bowel Disease (IBD).
Topics: Acute Disease; Animals; Azoxymethane; Cell Transformation, Neoplastic; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Mice; Trinitrobenzenesulfonic Acid | 2017 |
Enzymatically synthesized glycogen inhibits colitis through decreasing oxidative stress.
Topics: Animals; Colitis; Dextran Sulfate; Gastrointestinal Tract; Gene Expression Regulation; Gene Knockdown Techniques; Glycogen; Heme Oxygenase-1; Humans; MAP Kinase Signaling System; Membrane Proteins; Mice; NF-E2-Related Factor 2; Oxidative Stress; RAW 264.7 Cells; Trinitrobenzenesulfonic Acid | 2017 |
Evaluation of anti-inflammatory effect of silver-coated glass beads in mice with experimentally induced colitis as a new type of treatment in inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Chemistry, Pharmaceutical; Colitis; Colitis, Ulcerative; Crohn Disease; Dextran Sulfate; Disease Models, Animal; Inflammation; Male; Mice; Mice, Inbred BALB C; Silver; Trinitrobenzenesulfonic Acid | 2017 |
Maternal exposure to low levels of corticosterone during lactation protects adult rat progeny against TNBS-induced colitis: A study on GR-mediated anti-inflammatory effect and prokineticin system.
Topics: Animals; Breast Feeding; Colitis; Corticosterone; Disease Models, Animal; Female; Gastrointestinal Hormones; Gene Expression; Lactation; Male; Maternal Exposure; NF-kappa B; Rats; Receptors, Glucocorticoid; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2017 |
Investigation of mitigating effect of colon-specific prodrugs of boswellic acid on 2,4,6-trinitrobenzene sulfonic acid-induced colitis in Wistar rats: Design, kinetics and biological evaluation.
Topics: Amides; Animals; Colitis; Colon; Drug Delivery Systems; Drug Design; Feces; Inflammatory Bowel Diseases; Kinetics; Male; Prodrugs; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Triterpenes | 2017 |
P2X7 receptor promotes intestinal inflammation in chemically induced colitis and triggers death of mucosal regulatory T cells.
Topics: Animals; Colitis; Female; Immunity, Mucosal; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Mice, Knockout; Oxazolone; Receptors, Purinergic P2X7; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2017 |
Protective Effect of Protocatechuic Acid on TNBS-Induced Colitis in Mice Is Associated with Modulation of the SphK/S1P Signaling Pathway.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Glutathione; Hydroxybenzoates; Interleukin-1beta; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Oxidative Stress; Peroxidase; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Proprotein Convertases; Serine Endopeptidases; Signal Transduction; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Gain | 2017 |
The transcription factor IFN regulatory factor-4 controls experimental colitis in mice via T cell-derived IL-6.
Topics: Adoptive Transfer; Adult; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Colitis; Cytokines; DNA-Binding Proteins; Female; Gene Expression Regulation; Humans; Inflammatory Bowel Diseases; Interferon Regulatory Factors; Interleukin-6; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Oxazolone; Receptors, Interleukin-6; Recombinant Fusion Proteins; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2008 |
The relevance of kinin B1 receptor upregulation in a mouse model of colitis.
Topics: Animals; Colitis; Colon; In Vitro Techniques; Indicators and Reagents; Kallidin; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nitric Oxide Synthase Type II; Peroxidase; Receptor, Bradykinin B1; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
Pleiotropic effects of bombesin and neurotensin on intestinal mucosa: not just trefoil peptides.
Topics: Animals; Apoptosis; Bombesin; Cell Proliferation; Colitis; Disease Models, Animal; Intestinal Mucosa; Neurotensin; Neurotransmitter Agents; Oxidative Stress; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Transient receptor potential ankyrin-1 participates in visceral hyperalgesia following experimental colitis.
Topics: Animals; Ankyrins; Calcium Channels; Colitis; Colon; Disease Models, Animal; Electromyography; Gastrointestinal Motility; Hyperalgesia; Male; Oligodeoxyribonucleotides, Antisense; Pain Measurement; Pain Threshold; Rats; Rats, Wistar; Stimulation, Chemical; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels; Up-Regulation; Visceral Afferents | 2008 |
Intestinal anti-inflammatory activity of coumarin and 4-hydroxycoumarin in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: 4-Hydroxycoumarins; Acute Disease; Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Chronic Disease; Colitis; Colon; Coumarins; Diarrhea; Gastrointestinal Agents; Glutathione; Male; Organ Size; Peroxidase; Rats; Rats, Wistar; Secondary Prevention; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2008 |
A2B adenosine receptor gene deletion attenuates murine colitis.
Topics: Animals; Cell Migration Assays, Leukocyte; Chemokine CXCL1; Colitis; Colon; Dextran Sulfate; Disease Susceptibility; Female; Flagellin; Gene Deletion; Inflammation Mediators; Interleukin-8; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Peroxidase; Receptor, Adenosine A2B; Salmonella Infections; Salmonella typhimurium; Trinitrobenzenesulfonic Acid | 2008 |
Intrahepatic CD8(+) lymphocyte trapping during tolerance induction using mushroom derived formulations: a possible role for liver in tolerance induction.
Topics: Animals; CD4-CD8 Ratio; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Immune Tolerance; Interferon-gamma; Killer Cells, Natural; Liver; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Severity of Illness Index; Shiitake Mushrooms; Trinitrobenzenesulfonic Acid | 2008 |
The effect of Saccharomyces boulardii on human colon cells and inflammation in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Epithelial Cells; Gene Expression Regulation; HT29 Cells; Humans; Interleukin-8; Intestinal Mucosa; Male; Mice; NF-kappa B; PPAR gamma; Rats; Rats, Sprague-Dawley; RNA, Messenger; Saccharomyces; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Effects of glutamine on proinflammatory gene expression and activation of nuclear factor kappa B and signal transducers and activators of transcription in TNBS-induced colitis.
Topics: Analysis of Variance; Animals; Blotting, Western; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glutamine; Inflammation Mediators; Male; Manometry; NF-kappa B; Oxidative Stress; Probability; Random Allocation; Rats; Sensitivity and Specificity; Signal Transduction; Statistics, Nonparametric; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Up-Regulation | 2008 |
Therapeutic potential of two probiotics in inflammatory bowel disease as observed in the trinitrobenzene sulfonic acid model of colitis.
Topics: Animals; Bifidobacterium; Colitis; Disease Models, Animal; Lactobacillus; Male; Peroxidase; Probiotics; Rats; Rats, Wistar; Streptococcus thermophilus; Trinitrobenzenesulfonic Acid | 2008 |
Points of control exerted along the macrophage-endothelial cell-polymorphonuclear neutrophil axis by PECAM-1 in the innate immune response of acute colonic inflammation.
Topics: Acute Disease; Animals; Cell Adhesion; Cell Movement; Cells, Cultured; Colitis; Endothelial Cells; Immunity, Innate; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Mimicry; Neutrophils; Platelet Endothelial Cell Adhesion Molecule-1; Trinitrobenzenesulfonic Acid | 2008 |
Anti-Inflammatory mechanisms of enteric Heligmosomoides polygyrus infection against trinitrobenzene sulfonic acid-induced colitis in a murine model.
Topics: Animals; Colitis; Colon; Cytokines; Exudates and Transudates; Female; Inflammation; Intestinal Mucosa; Mast Cells; Mice; Mice, Inbred BALB C; Nematospiroides dubius; Trinitrobenzenesulfonic Acid | 2008 |
Melanin-concentrating hormone as a mediator of intestinal inflammation.
Topics: Animals; Colitis; Colon; Enteric Nervous System; Humans; Hypothalamic Hormones; Inflammation; Interleukin-8; Intestinal Mucosa; Intestines; Male; Melanins; Mice; Mice, Transgenic; Neuropeptides; Pituitary Hormones; Trinitrobenzenesulfonic Acid | 2008 |
Effect of intestinal inflammation on neuronal survival and function in the dorsal motor nucleus of the vagus.
Topics: Animals; Apoptosis; Calcium; Cell Proliferation; Cells, Cultured; Colitis; Cytokines; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Rats; Rats, Sprague-Dawley; Stomach; Trinitrobenzenesulfonic Acid; Vagus Nerve | 2008 |
Effects of ghrelin on neuronal survival in cells derived from dorsal motor nucleus of the vagus.
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Colitis; Gastrointestinal Tract; Ghrelin; Indomethacin; Male; Medulla Oblongata; Neural Pathways; Neurons, Efferent; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Receptors, Interleukin-6; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vagus Nerve | 2008 |
Mycophenolate mofetil promotes down-regulation of expanded B cells and production of TNF-alpha in an experimental murine model of colitis.
Topics: Animals; Antigens, CD19; Antigens, Surface; Apoptosis; B-Lymphocytes; Colitis; Disease Models, Animal; Down-Regulation; Female; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Mycophenolic Acid; NF-kappa B; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Regulation of intestinal barrier function by signal transducer and activator of transcription 5b.
Topics: Animals; Apoptosis; Caspase 3; Cells, Cultured; Colitis; Colon; Cytokines; Epithelial Cells; Growth Hormone; Inflammation Mediators; Intestinal Absorption; Intestinal Mucosa; Mice; Mice, Knockout; NF-kappa B; Permeability; Signal Transduction; STAT5 Transcription Factor; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid; Up-Regulation | 2009 |
Effect of different doses of Manuka honey in experimentally induced inflammatory bowel disease in rats.
Topics: Analysis of Variance; Animals; Antioxidants; Colitis; Colon; Disease Models, Animal; Glutathione; Honey; Inflammation; Inflammatory Bowel Diseases; Lipid Peroxidation; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2008 |
Melatonin reduces the expression of chemokines in rat with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Chemokines; Colitis; Disease Models, Animal; Female; Male; Melatonin; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Luminal antioxidants enhance the effects of mesalamine in the treatment of chemically induced colitis in rats.
Topics: Animals; Antioxidants; Ascorbic Acid; Colitis; Cyclic N-Oxides; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Intestinal Mucosa; Male; Mesalamine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Vitamin E | 2008 |
Oxymatrine improves TNBS-induced colitis in rats by inhibiting the expression of NF-kappaB p65.
Topics: Alkaloids; Animals; Colitis; Colon; Down-Regulation; Interleukin-10; Interleukin-2; Male; Quinolizines; Rats; Rats, Sprague-Dawley; Sophora; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2008 |
Acute and chronic responses associated with adrenomedullin administration in experimental colitis.
Topics: Acute Disease; Adrenomedullin; Animals; Anti-Inflammatory Agents; Chronic Disease; Colitis; Colon; Female; Interferon-gamma; Interleukin-10; Male; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Effects of N-acetylcysteine plus mesalamine on prostaglandin synthesis and nitric oxide generation in TNBS-induced colitis in rats.
Topics: Acetylcysteine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Drug Therapy, Combination; Free Radical Scavengers; Intestinal Mucosa; Male; Membrane Proteins; Mesalamine; Nitric Oxide; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2009 |
Decreased total antioxidant capacity in plasma, but not tissue, in experimental colitis.
Topics: Animals; Antioxidants; Biomarkers; Colitis; Colon; Cyclooxygenase Inhibitors; Diclofenac; Male; Oxidative Stress; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Clotrimazole ameliorates intestinal inflammation and abnormal angiogenesis by inhibiting interleukin-8 expression through a nuclear factor-kappaB-dependent manner.
Topics: Angiogenesis Inhibitors; Animals; Antifungal Agents; Cell Adhesion; Cells, Cultured; Chick Embryo; Clotrimazole; Colitis; HT29 Cells; Humans; Interleukin-8; NF-kappa B; Rats; Rats, Sprague-Dawley; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid; U937 Cells | 2008 |
The effect of Hypericum perforatum (St. John's Wort) on experimental colitis in rat.
Topics: Animals; Catalase; Colitis; Glutathione; Granulocyte Colony-Stimulating Factor; Hypericum; Interleukin-3; Male; Malondialdehyde; Nitric Oxide; Plant Extracts; Rats; Rats, Wistar; Receptors, Peptide; Recombinant Fusion Proteins; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 2009 |
TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats.
Topics: Afferent Pathways; Animals; Colitis; Electrophysiology; Female; Gene Expression Regulation; Immunohistochemistry; Pain; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2008 |
Corticotropin-releasing hormone receptor 1 antagonist blocks colonic hypersensitivity induced by a combination of inflammation and repetitive colorectal distension.
Topics: Animals; Colitis; Colon; Dilatation, Pathologic; Electromyography; Humans; Inflammation; Irritable Bowel Syndrome; Male; Pyrimidines; Pyrroles; Rats; Rats, Wistar; Receptors, Corticotropin-Releasing Hormone; Trinitrobenzenesulfonic Acid | 2008 |
Increased duodenal expression of transforming growth factor-alpha and epidermal growth factor during experimental colitis in rats.
Topics: Animals; Colitis; Colon; Duodenum; Epidermal Growth Factor; Ethanol; Gene Expression; Intestinal Mucosa; Male; Models, Animal; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor alpha; Trinitrobenzenesulfonic Acid | 2008 |
Treatment with bindarit, an inhibitor of MCP-1 synthesis, protects mice against trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Cells, Cultured; Chemokine CCL2; Colitis; Disease Progression; Epithelial Cells; Female; Humans; Indazoles; Interferon-gamma; Mice; Mice, Inbred BALB C; Propionates; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis.
Topics: Alternative Splicing; Animals; Claudins; Colitis; Colitis, Ulcerative; Female; Gene Expression Profiling; Humans; Male; Membrane Proteins; Mice; Mice, Inbred C57BL; Occludin; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis.
Topics: Animals; Cluster Analysis; Colitis; Colon; Disease Models, Animal; Female; Gene Expression Profiling; Genomics; Inflammatory Bowel Diseases; Oligonucleotide Array Sequence Analysis; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Early Growth Response Protein 1; Enzyme-Linked Immunosorbent Assay; Female; Fibroblasts; Fibrosis; Gene Expression Regulation; Insulin-Like Growth Factor I; Interleukin-13; Interleukin-13 Receptor alpha2 Subunit; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; RNA; Signal Transduction; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Zinc Fingers | 2008 |
Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis.
Topics: Animals; Blotting, Western; Chronic Disease; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Disease Progression; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Female; Immunohistochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peroxidase; Trinitrobenzenesulfonic Acid | 2009 |
Microglial activation and TNFalpha production mediate altered CNS excitability following peripheral inflammation.
Topics: Animals; Central Nervous System; Colitis; Cytokines; Hippocampus; Male; Microglia; Rats; Rats, Sprague-Dawley; Seizures; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Dexamethasone 21-sulfate improves the therapeutic properties of dexamethasone against experimental rat colitis by specifically delivering the steroid to the large intestine.
Topics: Administration, Oral; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dexamethasone; Disease Models, Animal; Feces; Gastrointestinal Agents; Hydrocortisone; Intestinal Absorption; Male; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfates; Trinitrobenzenesulfonic Acid | 2009 |
Attenuation of colitis injury in rats using Garcinia cambogia extract.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dinoprostone; Disease Models, Animal; DNA Damage; Female; Garcinia cambogia; Inflammation Mediators; Male; Peroxidase; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic potential of helminth soluble proteins in TNBS-induced colitis in mice.
Topics: Ancylostoma; Animals; Colitis; Colon; Cytokines; Gene Expression; Helminth Proteins; Immunosuppressive Agents; Lymph Nodes; Male; Mice; Schistosoma mansoni; Solubility; Spleen; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2009 |
Short-chain inulin-like fructans reduce endotoxin and bacterial translocations and attenuate development of TNBS-induced colitis in rats.
Topics: Animals; Bacterial Translocation; Cecum; Colitis; Endotoxins; Fermentation; Fructans; Hydrogen-Ion Concentration; Immunoglobulin A; Lymph Nodes; Male; Mesentery; Mucins; Polymers; Rats; Rats, Inbred F344; Trinitrobenzenesulfonic Acid | 2009 |
Progression and variability of TNBS colitis-associated inflammation in rats assessed by contrast-enhanced and T2-weighted MRI.
Topics: Anesthetics, Inhalation; Animals; Colitis; Colon; Contrast Media; Disease Models, Animal; Disease Progression; Gastrointestinal Agents; Isoflurane; Magnetic Resonance Imaging; Male; Organ Size; Rats; Rats, Wistar; Severity of Illness Index; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2009 |
[The therapeutic effects of heparin on TNBS-induced rat colitis model].
Topics: Animals; Anticoagulants; Colitis; Disease Models, Animal; Heparin; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Role of serotonin in intestinal inflammation: knockout of serotonin reuptake transporter exacerbates 2,4,6-trinitrobenzene sulfonic acid colitis in mice.
Topics: Animals; Colitis; Colon; Gastrointestinal Motility; Histamine; Mice; Mice, Inbred C57BL; Mice, Knockout; Peroxidase; Rectum; Serotonin; Serotonin Plasma Membrane Transport Proteins; Trinitrobenzenesulfonic Acid | 2009 |
Tumor necrosis factor-{alpha} downregulates intestinal NHE8 expression by reducing basal promoter activity.
Topics: Animals; Base Sequence; Caco-2 Cells; Cloning, Molecular; Colitis; Diarrhea; Disease Models, Animal; Down-Regulation; Humans; Intestinal Mucosa; Jejunum; Lipopolysaccharides; Male; Microvilli; Molecular Sequence Data; Nucleic Acid Synthesis Inhibitors; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Recombinant Proteins; RNA, Messenger; Sodium-Hydrogen Exchangers; Sp3 Transcription Factor; Time Factors; Transcription Initiation Site; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Inhibition of endothelial cell adhesion molecule expression improves colonic hyperalgaesia.
Topics: Animals; Cell Adhesion; Cell Adhesion Molecules; Colitis; Colon; Dilatation, Pathologic; E-Selectin; Endothelial Cells; Gastrointestinal Motility; Humans; Hyperalgesia; Intercellular Adhesion Molecule-1; Leukocytes; Male; Polyethylene Glycols; Purines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological; Trinitrobenzenesulfonic Acid; Zymosan | 2009 |
Peripheral anti-nociceptive effect of nociceptin/orphanin FQ in inflammation and stress-induced colonic hyperalgesia in rats.
Topics: Analgesics; Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Routes; Drug Interactions; Electromyography; Gene Expression Regulation; Hyperalgesia; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peroxidase; Physical Stimulation; Rats; Rats, Wistar; Receptors, Opioid; Restraint, Physical; Sensory Thresholds; Stress, Psychological; Trinitrobenzenesulfonic Acid | 2009 |
Depot-specific alterations to insulin signaling in mesenteric adipose tissue during intestinal inflammatory response.
Topics: Adipose Tissue; Animals; Colitis; Insulin; Insulin Receptor Substrate Proteins; Intestinal Mucosa; Intestines; Male; Mesentery; Peroxidase; Phosphorylation; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid; Tyrosine | 2009 |
Matrix metalloproteinase-9-mediated tissue injury overrides the protective effect of matrix metalloproteinase-2 during colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Drug Design; Female; Gastrointestinal Agents; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Protease Inhibitors; Salmonella typhimurium; Trinitrobenzenesulfonic Acid | 2009 |
L-carnitine, a diet component and organic cation transporter OCTN ligand, displays immunosuppressive properties and abrogates intestinal inflammation.
Topics: Animals; Carnitine; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Immunologic; Drug Evaluation, Preclinical; Immunosuppressive Agents; Inflammation Mediators; Lipopolysaccharides; Lymphocyte Activation; Macrophages; Male; Mice; Mice, Inbred BALB C; Organic Cation Transport Proteins; Solute Carrier Family 22 Member 5; Spleen; Trinitrobenzenesulfonic Acid | 2009 |
Pectin/Kollicoat SR30D isolated films for colonic delivery [I]: a comparison of normal and colitis-induced models to assess the efficiency of microbially triggered drug delivery.
Topics: Animals; Cecum; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Fluorouracil; Glass; Oxazolone; Pectins; Permeability; Polyvinyls; Rats; Steam; Temperature; Trinitrobenzenesulfonic Acid | 2009 |
Tumor necrosis factor-alpha impairs intestinal phosphate absorption in colitis.
Topics: Animals; Caco-2 Cells; Colitis; DNA; ErbB Receptors; Gene Expression Regulation; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Phosphates; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA; Sodium-Phosphate Cotransporter Proteins, Type II; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Optimization of budesonide compression-coated tablets for colonic delivery.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Budesonide; Calorimetry, Differential Scanning; Cellulose; Chemistry, Pharmaceutical; Colitis; Colon; Delayed-Action Preparations; Disease Models, Animal; Drug Carriers; Drug Compounding; Galactans; Gastrointestinal Agents; Hydrogen-Ion Concentration; Hypromellose Derivatives; Kinetics; Male; Mannans; Methylcellulose; Pectins; Plant Gums; Polymethacrylic Acids; Rabbits; Rheology; Solubility; Tablets, Enteric-Coated; Technology, Pharmaceutical; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic effects of rectal administration of muscovite on experimental colitis in rats.
Topics: Administration, Rectal; Aluminum Silicates; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; HT29 Cells; Humans; Interleukin-1beta; Mesalamine; Mucin-2; Neuropeptides; Rats; Rats, Sprague-Dawley; Trefoil Factor-3; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Alterations to enteric neural signaling underlie secretory abnormalities of the ileum in experimental colitis in the guinea pig.
Topics: Animals; Colitis; Guinea Pigs; Ileum; Intestinal Mucosa; Male; Neurons; Signal Transduction; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2009 |
Oral treatment with genistein reduces the expression of molecular and biochemical markers of inflammation in a rat model of chronic TNBS-induced colitis.
Topics: Administration, Oral; Animals; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Genistein; Genitalia, Male; Inflammation; Male; Organ Size; Peroxidase; Proliferating Cell Nuclear Antigen; Random Allocation; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2009 |
Nitric oxide increases Wnt-induced secreted protein-1 (WISP-1/CCN4) expression and function in colitis.
Topics: Animals; beta Catenin; Blotting, Western; Caco-2 Cells; CCN Intercellular Signaling Proteins; Cell Line, Tumor; Colitis; Colitis, Ulcerative; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Gene Expression; HT29 Cells; Humans; Interleukin-10; Intracellular Signaling Peptides and Proteins; Mice; Mice, Knockout; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroso Compounds; Oncogene Proteins; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Time Factors; Trinitrobenzenesulfonic Acid | 2009 |
Effects of trefoil peptide 3 on expression of TNF-alpha, TLR4, and NF-kappaB in trinitrobenzene sulphonic acid induced colitis mice.
Topics: Animals; Colitis; Colon; Humans; Mice; Mice, Inbred BALB C; NF-kappa B; Peptides; Recombinant Proteins; Signal Transduction; Toll-Like Receptor 4; Trefoil Factor-3; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Trinitrobenzenesulphonic acid colitis alters Na 1.8 channel expression in mouse dorsal root ganglia neurons.
Topics: Animals; Colitis; Colon; Ganglia, Spinal; Mice; NAV1.8 Voltage-Gated Sodium Channel; NAV1.9 Voltage-Gated Sodium Channel; Neurons; Neuropeptides; Protein Subunits; Sodium Channels; Trinitrobenzenesulfonic Acid | 2009 |
Lactobacillus fermentum CECT 5716 prevents and reverts intestinal damage on TNBS-induced colitis in mice.
Topics: Animals; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Eicosanoids; Immunoenzyme Techniques; Intestinal Mucosa; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Myeloid Differentiation Factor 88; Peroxidase; Probiotics; Trinitrobenzenesulfonic Acid; Tyrosine | 2009 |
Minocycline attenuates experimental colitis in mice by blocking expression of inducible nitric oxide synthase and matrix metalloproteinases.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Enzyme Inhibitors; Inflammation; Male; Matrix Metalloproteinases; Metronidazole; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Minocycline; Nitric Oxide Synthase Type II; RNA, Messenger; Species Specificity; Survival Analysis; Trinitrobenzenesulfonic Acid | 2009 |
Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses.
Topics: Afferent Pathways; Animals; Colitis; Colon; Irritable Bowel Syndrome; Male; Mechanoreceptors; Mice; Mice, Inbred C57BL; Splanchnic Nerves; Time Factors; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2009 |
pH-Sensitive nanospheres for colon-specific drug delivery in experimentally induced colitis rat model.
Topics: Animals; Budesonide; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Hydrogen-Ion Concentration; Inflammatory Bowel Diseases; Nanospheres; Nanotechnology; Polymers; Rats; Tablets, Enteric-Coated; Trinitrobenzenesulfonic Acid | 2009 |
Endogenous IGF-I and alpha v beta3 integrin ligands regulate increased smooth muscle growth in TNBS-induced colitis.
Topics: Animals; Apoptosis; Cell Proliferation; Colitis; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Fibronectins; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hyperplasia; Insulin-Like Growth Factor I; Integrin alphaVbeta3; Intercellular Signaling Peptides and Proteins; Ligands; Muscle, Smooth; Myocytes, Smooth Muscle; Peptides; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Sprague-Dawley; Ribosomal Protein S6 Kinases, 70-kDa; Trinitrobenzenesulfonic Acid; Vitronectin | 2009 |
Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats.
Topics: Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Disease Models, Animal; Glyburide; Hydrogen Sulfide; Immunohistochemistry; Male; Pinacidil; Probability; Random Allocation; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity; Statistics, Nonparametric; Survival Rate; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
Halofuginone, a specific inhibitor of collagen type 1 synthesis, ameliorates oxidant colonic damage in rats with experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Collagen; Collagen Type I; Colon; Female; Glutathione; Luminescence; Male; Malondialdehyde; Organ Size; Peroxidase; Piperidines; Protein Synthesis Inhibitors; Quinazolinones; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Spinal NMDA NR1 subunit expression following transient TNBS colitis.
Topics: Analysis of Variance; Animals; Blotting, Western; Colitis; Electrophoresis, Gel, Two-Dimensional; Hot Temperature; Immunohistochemistry; Male; Pain; Pain Measurement; Photomicrography; Physical Stimulation; Protein Isoforms; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Trinitrobenzenesulfonic Acid | 2009 |
Vanillin improves and prevents trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Benzaldehydes; Colitis; Female; Mice; Mice, Inbred BALB C; Mice, Transgenic; Trinitrobenzenesulfonic Acid | 2009 |
Relationship between mast cells and the colitis with relapse induced by trinitrobenzesulphonic acid in Wistar rats.
Topics: Animals; Colitis; Colon; Gastrointestinal Agents; Histamine; Male; Mast Cells; Microscopy; Nedocromil; Rats; Rats, Wistar; Sulfasalazine; Thioxanthenes; Trinitrobenzenesulfonic Acid; Xanthones | 2009 |
Neurotensin induces IL-6 secretion in mouse preadipocytes and adipose tissues during 2,4,6,-trinitrobenzensulphonic acid-induced colitis.
Topics: 3T3-L1 Cells; Adipocytes; Adipose Tissue; Animals; Cell Differentiation; Cell Movement; Colitis; Interleukin-6; Macrophages; Mice; Mice, Knockout; Neurotensin; NF-kappa B; Phosphorylation; Protein Kinase C-delta; Protein Subunits; Receptors, Neurotensin; Signal Transduction; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic effects of mucosal tolerance on experimental colitis in rats.
Topics: Adjuvants, Immunologic; Administration, Intranasal; Administration, Oral; Animals; Antigens; Colitis; Desensitization, Immunologic; Disease Models, Animal; Immune Tolerance; Immunity, Mucosal; Inflammatory Bowel Diseases; Intestinal Mucosa; Lipopolysaccharides; Male; Ovalbumin; Rats; Rats, Sprague-Dawley; T-Lymphocytes, Regulatory; Toll-Like Receptors; Trinitrobenzenesulfonic Acid | 2009 |
Prevention of TNBS-induced colitis by different Lactobacillus and Bifidobacterium strains is associated with an expansion of gammadeltaT and regulatory T cells of intestinal intraepithelial lymphocytes.
Topics: Animals; Bifidobacterium; Colitis; Cytokines; Feces; Female; Intestinal Mucosa; Lactobacillus; Lymphocytes; Mice; Mice, Inbred BALB C; Probiotics; Receptors, Antigen, T-Cell, gamma-delta; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2009 |
Anti-CTLA-4 treatment induces IL-10-producing ICOS+ regulatory T cells displaying IDO-dependent anti-inflammatory properties in a mouse model of colitis.
Topics: Animals; Antibodies, Monoclonal; Antigens, CD; Colitis; CTLA-4 Antigen; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interleukin-10; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2009 |
Therapeutic action and underlying mechanisms of a combination of two pentacyclic triterpenes, alpha- and beta-amyrin, in a mouse model of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Drug Therapy, Combination; Male; Mice; Oleanolic Acid; Pentacyclic Triterpenes; Trinitrobenzenesulfonic Acid | 2009 |
Blocking CD27-CD70 costimulatory pathway suppresses experimental colitis.
Topics: Adoptive Transfer; Animals; Antibodies, Monoclonal; CD27 Ligand; CD4-Positive T-Lymphocytes; Cell Movement; Colitis; Cytokines; Disease Models, Animal; Inflammation Mediators; Intestinal Mucosa; Ligands; Mice; Mice, Inbred C57BL; Mice, Knockout; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Receptor Superfamily, Member 7 | 2009 |
Sulfate-conjugated methylprednisolone as a colon-targeted methylprednisolone prodrug with improved therapeutic properties against rat colitis.
Topics: Administration, Oral; Adrenal Glands; Animals; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Glucocorticoids; Male; Methylprednisolone; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfates; Thymus Gland; Trinitrobenzenesulfonic Acid | 2009 |
(-)-Epigallocatechin-3-gallate reduces experimental colon injury in rats by regulating macrophage and mast cell.
Topics: Animals; Catechin; Chemotaxis; Colitis; Histamine; Macrophages; Male; Mast Cells; N-Formylmethionine Leucyl-Phenylalanine; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
FoxO4 inhibits NF-kappaB and protects mice against colonic injury and inflammation.
Topics: Animals; Caco-2 Cells; CD4-Positive T-Lymphocytes; Cell Cycle Proteins; Colitis; Colon; Cytokines; Disease Models, Animal; Forkhead Transcription Factors; Gene Expression Profiling; Humans; Immunity, Mucosal; Inflammatory Bowel Diseases; Mice; Mice, Knockout; NF-kappa B; Permeability; RNA, Messenger; Signal Transduction; Tight Junctions; Time Factors; Transcription Factors; Transcription, Genetic; Transfection; Trinitrobenzenesulfonic Acid; Up-Regulation | 2009 |
Comparison of the population capacity of hematopoietic and mesenchymal stem cells in experimental colitis rat model.
Topics: Animals; Cell Proliferation; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Female; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Immunohistochemistry; In Situ Hybridization, Fluorescence; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Sex-Determining Region Y Protein; Time Factors; Transplantation, Homologous; Trinitrobenzenesulfonic Acid; Y Chromosome | 2009 |
Glycosaminoglycan degradation-inhibitory lactic acid bacteria ameliorate 2,4,6-trinitrobenzenesulfonic acid-induced colitis in mice.
Topics: Animals; Bifidobacterium; Colitis; Cyclooxygenase 2; Gene Expression Regulation; Glycosaminoglycans; Interleukin-1beta; Lactobacillus plantarum; Male; Mice; NF-kappa B; Probiotics; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli.
Topics: Action Potentials; Afferent Pathways; Animals; Bradykinin; Capsaicin; Colitis; Colon; Disease Models, Animal; Female; Ganglia, Spinal; Hyperalgesia; Immunohistochemistry; In Situ Hybridization; Intestinal Mucosa; Male; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuroanatomical Tract-Tracing Techniques; Nodose Ganglion; Pain Measurement; Pelvis; Pressure; Receptor, PAR-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Splanchnic Nerves; Stimulation, Chemical; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel | 2009 |
Blood flow patterns spatially associated with platelet aggregates in murine colitis.
Topics: Acute Disease; Animals; Blood Platelets; Chemokines; Colitis; Dextran Sulfate; Endothelium, Vascular; Gene Expression Profiling; Interleukin-1beta; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microcirculation; Platelet Aggregation; Regional Blood Flow; Trinitrobenzenesulfonic Acid | 2009 |
Homeostatic and therapeutic roles of VIP in smooth muscle function: myo-neuroimmune interactions.
Topics: Acetylcholine; Active Transport, Cell Nucleus; Animals; Binding Sites; Calcium Channels, L-Type; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Enteric Nervous System; Homeostasis; Hormone Antagonists; Humans; I-kappa B Proteins; In Vitro Techniques; Inflammation Mediators; Infusions, Subcutaneous; Muscle Contraction; Muscle, Smooth; Neuroimmunomodulation; NF-kappa B; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, Vasoactive Intestinal Peptide, Type II; Receptors, Vasoactive Intestinal Polypeptide, Type I; Time Factors; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vasoactive Intestinal Peptide | 2009 |
Obesity predisposes to Th17 bias.
Topics: Animals; Colitis; Disease Models, Animal; Encephalomyelitis, Autoimmune, Experimental; Glycoproteins; Interleukin-17; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; Obesity; Peptide Fragments; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2009 |
[Therapeutic effect of allogenic bone marrow transplantation in acute TNBS-induced colitis].
Topics: Actins; Acute Disease; Animals; Bone Marrow Transplantation; Colitis; Female; Fibroblasts; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Transplantation, Homologous; Trinitrobenzenesulfonic Acid; Vimentin | 2009 |
The possible mechanisms of Fructus Mume pill in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Topics: Animals; Body Weight; Colitis; Cytokines; Dexamethasone; Diarrhea; Herbal Medicine; Intestines; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2009 |
A role for CD47 in the development of experimental colitis mediated by SIRPalpha+CD103- dendritic cells.
Topics: Animals; Antigens, CD; CD47 Antigen; Colitis; Dendritic Cells; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Integrin alpha Chains; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Knockout; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Wasting Syndrome | 2009 |
Computational flow dynamics in a geometric model of intussusceptive angiogenesis.
Topics: Animals; Biomechanical Phenomena; Blood Circulation; Blood Vessels; Colitis; Computational Biology; Computer Simulation; Disease Models, Animal; Mice; Mice, Inbred BALB C; Models, Biological; Neovascularization, Pathologic; Shear Strength; Stress, Mechanical; Trinitrobenzenesulfonic Acid | 2009 |
Inhibitory effects of Geijigajakyak-Tang on trinitrobenzene sulfonic acid-induced colitis.
Topics: Acrolein; Animals; Anti-Inflammatory Agents; Antioxidants; Benzoates; Bridged-Ring Compounds; Chemotaxis; Colitis; Cyclohexanols; Eucalyptol; Female; Glucosides; Glycyrrhizic Acid; Ileum; Lipid Peroxidation; Magnoliopsida; Malondialdehyde; Mice; Mice, Inbred BALB C; Models, Animal; Monoterpenes; Muscle Contraction; Muscle, Smooth; Neutrophils; Parasympatholytics; Peroxidase; Phytotherapy; Plant Extracts; Saponins; Trinitrobenzenesulfonic Acid; Triterpenes | 2009 |
Si-Ni-San, a traditional Chinese prescription, and its active ingredient glycyrrhizin ameliorate experimental colitis through regulating cytokine balance.
Topics: Animals; Body Weight; Colitis; Colon; Crohn Disease; Cytokines; Diarrhea; Disease Models, Animal; Drugs, Chinese Herbal; Female; Glycyrrhizic Acid; Humans; Medicine, Chinese Traditional; Mice; Mice, Inbred C57BL; Peroxidase; Trinitrobenzenesulfonic Acid | 2009 |
N-Methyl-D-aspartate receptor antagonism decreases motility and inflammatory activation in the early phase of acute experimental colitis in the rat.
Topics: Analysis of Variance; Animals; Blood Pressure; Colitis; Colon; Disease Models, Animal; Excitatory Amino Acid Antagonists; Gastrointestinal Motility; Inflammation; Kynurenic Acid; Male; Nitric Oxide Synthase; Peroxidase; Random Allocation; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Xanthine Oxidase | 2010 |
Development of recombinant vaccines against IL-12/IL-23 p40 and in vivo evaluation of their effects in the downregulation of intestinal inflammation in murine colitis.
Topics: Animals; Antibody Affinity; Colitis; Collagen; Colon; Crohn Disease; Immunoglobulin G; Inflammation; Interleukin-12 Subunit p40; Interleukin-23; Male; Mice; Mice, Inbred BALB C; Models, Animal; Trinitrobenzenesulfonic Acid; Vaccines, Synthetic | 2009 |
Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid.
Topics: Animals; Atrophy; Colitis; Colon; Dexamethasone; Immunomodulation; Immunosuppressive Agents; Intestinal Diseases; Male; Nanocapsules; NF-kappa B; Polysaccharides; Rats; Rats, Sprague-Dawley; Rheum; Thymus Gland; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2009 |
Modulation of the colonic epithelial cell responses and amelioration of inflammation by CD80 blockade in TNBS colitis.
Topics: Animals; B7-1 Antigen; CD4-Positive T-Lymphocytes; Colitis; Epithelial Cells; Flow Cytometry; Histocytochemistry; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Oligopeptides; Reverse Transcriptase Polymerase Chain Reaction; RNA; Specific Pathogen-Free Organisms; Th1 Cells; Th2 Cells; Toll-Like Receptors; Trinitrobenzenesulfonic Acid | 2009 |
Intestinal inflammation and seizure susceptibility: understanding the role of tumour necrosis factor-alpha in a rat model.
Topics: Animals; Brain; Catalase; Colitis; Colon; Disease Models, Animal; Female; Glutathione Peroxidase; Lipid Peroxidation; Male; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Superoxide Dismutase; Thalidomide; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
A33 antigen-deficient mice have defective colonic mucosal repair.
Topics: Animals; Antigens, Neoplasm; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Female; Haptens; Intestinal Mucosa; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid; Wound Healing | 2010 |
The bile acid receptor FXR is a modulator of intestinal innate immunity.
Topics: Acute Disease; Adult; Animals; Chronic Disease; Colitis; Crohn Disease; Female; Humans; Immunity, Innate; Interleukin-1beta; Intestinal Mucosa; Intestines; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; NF-kappa B; Receptors, Cytoplasmic and Nuclear; Trinitrobenzenesulfonic Acid | 2009 |
Bifidobacterium longum HY8004 attenuates TNBS-induced colitis by inhibiting lipid peroxidation in mice.
Topics: Animals; Anti-Infective Agents; Bifidobacterium; Cell Line; Colitis; Colon; Humans; Lipid Peroxidation; Liposomes; Male; Mice; NF-kappa B; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2010 |
Targeting TGF-beta1 by employing a vaccine ameliorates fibrosis in a mouse model of chronic colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Female; Fibrosis; Immunoglobulin G; Interleukin-17; Interleukin-23; Lymph Nodes; Mesentery; Mice; Mice, Inbred BALB C; Phosphorylation; Smad3 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Vaccines, Synthetic | 2010 |
Oxytocin treatment alleviates stress-aggravated colitis by a receptor-dependent mechanism.
Topics: Animals; Anxiety; Colitis; Colon; Female; Male; Oxytocin; Rats; Rats, Sprague-Dawley; Receptors, Oxytocin; Stress, Psychological; Trinitrobenzenesulfonic Acid; Vasotocin | 2010 |
The role of brain-derived neurotrophic factor in experimental inflammation of mouse gut.
Topics: Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Colitis; Colon; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Hyperalgesia; Inflammation; Male; Mice; Mice, Knockout; Physical Stimulation; Random Allocation; Trinitrobenzenesulfonic Acid; Up-Regulation; Urinary Bladder | 2010 |
Bioefficacy of budesonide loaded crosslinked polyelectrolyte microparticles in rat model of induced colitis.
Topics: Alginates; Animals; Anti-Inflammatory Agents; Budesonide; Calcium Chloride; Chitosan; Colitis; Cross-Linking Reagents; Delayed-Action Preparations; Disease Models, Animal; Drug Delivery Systems; Electrolytes; Glucuronic Acid; Hexuronic Acids; Male; Microspheres; Polymethacrylic Acids; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2009 |
Targeting delivery of anti-TNFalpha oligonucleotide into activated colonic macrophages protects against experimental colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Gene Targeting; Genetic Therapy; Genetic Vectors; Inflammation Mediators; Intestinal Mucosa; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotides, Antisense; Transfection; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Lancemaside A ameliorates colitis by inhibiting NF-kappaB activation in TNBS-induced colitis mice.
Topics: Animals; Cell Line; Colitis; Cyclooxygenase 2; Cytokines; Feces; Glucuronidase; Humans; Hyaluronic Acid; Inflammation Mediators; Lipopolysaccharides; Mice; NF-kappa B; Saponins; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2010 |
Proinflammatory and anti-inflammatory cytokines present in the acute phase of experimental colitis treated with Saccharomyces boulardii.
Topics: Acute Disease; Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Male; Probiotics; Rats; Rats, Wistar; Saccharomyces; Severity of Illness Index; Time Factors; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Nutriose, a prebiotic low-digestible carbohydrate, stimulates gut mucosal immunity and prevents TNBS-induced colitis in piglets.
Topics: Animals; Animals, Newborn; Colitis; Dextrins; Dietary Carbohydrates; Enzyme-Linked Immunosorbent Assay; Immunity, Mucosal; Immunoglobulin A, Secretory; Immunomodulation; Intestinal Mucosa; Male; Prebiotics; Reverse Transcriptase Polymerase Chain Reaction; Swine; Trinitrobenzenesulfonic Acid | 2010 |
Colitis affects the smooth muscle and neural response to motilin in the rabbit antrum.
Topics: Animals; Colitis; Enzyme Activation; Female; Male; Motilin; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; NF-kappa B; Peroxidase; Phosphorylation; Protein Kinase C; Pyloric Antrum; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neuropeptide; rho-Associated Kinases; Signal Transduction; Trinitrobenzenesulfonic Acid | 2010 |
Anti-inflammatory intestinal activity of Abarema cochliacarpos (Gomes) Barneby & Grimes in TNBS colitis model.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 2; Inflammation; Interleukin-10; Intestinal Mucosa; Intestines; JNK Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Inhalation of carbon monoxide ameliorates TNBS-induced colitis in mice through the inhibition of TNF-α expression.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Antibodies; Carbon Monoxide; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred C57BL; Peroxidase; RNA, Messenger; Spleen; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
[Saccharomyces boulardii reduced intestinal inflammation in mice model of 2,4,6-trinitrobencene sulfonic acid induced colitis: based on microarray].
Topics: Animals; Colitis; Colon; Gene Expression Profiling; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Probiotics; Saccharomyces; Trinitrobenzenesulfonic Acid | 2010 |
A new model of chronic hapten-induced colitis in young rats.
Topics: Animals; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Fibrosis; Haptens; Inflammation Mediators; Organ Size; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Ulcer | 2010 |
Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Gastrointestinal Motility; Helminth Proteins; Male; Mice; Peristalsis; Schistosoma mansoni; T-Lymphocyte Subsets; Trinitrobenzenesulfonic Acid | 2010 |
Preventive effects of Schistosoma japonicum ova on trinitrobenzenesulfonic acid-induced colitis and bacterial translocation in mice.
Topics: Animals; Bacterial Translocation; Colitis; Colon; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Injections, Intraperitoneal; Interferon-gamma; Interleukin-10; Mice; Mice, Inbred BALB C; Ovum; Polymerase Chain Reaction; RNA, Messenger; Schistosoma japonicum; T-Lymphocytes, Helper-Inducer; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2009 |
MicroRNA155 is induced in activated CD4(+) T cells of TNBS-induced colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Female; Lymph Nodes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; MicroRNAs; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2010 |
On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Gastrointestinal Agents; Inflammation Mediators; Interleukin-1beta; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Plant Components, Aerial; Plant Preparations; Rats; Rats, Wistar; Teucrium; Thiobarbituric Acid Reactive Substances; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Dietary medium-chain triglycerides prevent chemically induced experimental colitis in rats.
Topics: Animals; Cells, Cultured; Chemokine CXCL2; Colitis; Colon; Endotoxins; Interleukin-1beta; Male; Mice; Peroxidase; Rats; Rats, Wistar; Toll-Like Receptor 4; Triglycerides; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis.
Topics: Adjuvants, Immunologic; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Colitis; Dextran Sulfate; DNA; Female; Fluorescent Antibody Technique; Indoleamine-Pyrrole 2,3,-Dioxygenase; Intestinal Mucosa; Isoenzymes; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Mucous Membrane; Oligodeoxyribonucleotides; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Toll-Like Receptor 9; Trinitrobenzenesulfonic Acid | 2010 |
All-trans retinoic acid ameliorates trinitrobenzene sulfonic acid-induced colitis by shifting Th1 to Th2 profile.
Topics: Animals; Cells, Cultured; Colitis; Colon; Cytokines; Dibenzazepines; GATA3 Transcription Factor; Male; Mice; Mucous Membrane; Peroxidase; Retinoids; T-Box Domain Proteins; Th1 Cells; Th2 Cells; Tretinoin; Trinitrobenzenesulfonic Acid | 2010 |
Novel guggulsterone derivative GG-52 inhibits NF-kappaB signaling in intestinal epithelial cells and attenuates acute murine colitis.
Topics: Animals; Anti-Inflammatory Agents; Cell Line, Tumor; Chemokine CCL2; Colitis; Dextran Sulfate; Epithelial Cells; Humans; I-kappa B Kinase; Interleukin-8; Intestinal Mucosa; Mice; Mice, Inbred C57BL; NF-kappa B; Prednisolone; Pregnenediones; Pregnenes; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Combined administration of secretin and oxytocin inhibits chronic colitis and associated activation of forebrain neurons.
Topics: Amygdala; Animals; Cerebral Cortex; Chronic Disease; Colitis; Genes, fos; Injections, Intraperitoneal; Injections, Intraventricular; Interferon-gamma; Intestinal Mucosa; Male; Neurons; Oxytocin; Paraventricular Hypothalamic Nucleus; Prosencephalon; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Secretin; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vagotomy | 2010 |
CCL2 (pM levels) as a therapeutic agent in Inflammatory Bowel Disease models in mice.
Topics: Animals; Azoxymethane; Blotting, Western; Carcinogens; Cell Adhesion; Cell Movement; Cell Proliferation; Chemokine CCL2; Colitis; Colon; Colorectal Neoplasms; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Immunoenzyme Techniques; Inflammatory Bowel Diseases; Macrophages; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Monocytes; Trinitrobenzenesulfonic Acid | 2010 |
Mice lacking cannabinoid CB1-, CB2-receptors or both receptors show increased susceptibility to trinitrobenzene sulfonic acid (TNBS)-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Genetic Predisposition to Disease; Inflammation Mediators; Mice; Mice, Inbred AKR; Mice, Inbred C57BL; Mice, Knockout; Pilot Projects; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2010 |
Hematopoietic SCT modulates gut inflammation in experimental inflammatory bowel disease.
Topics: Animals; Bone Marrow Transplantation; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Combined Modality Therapy; Cyclosporine; Cytokines; Female; Hematopoietic Stem Cell Transplantation; Immunity, Mucosal; Immunosuppression Therapy; Immunosuppressive Agents; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Severity of Illness Index; Survival Analysis; Trinitrobenzenesulfonic Acid | 2010 |
4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease.
Topics: Acute Disease; Animals; Biphenyl Compounds; Blotting, Western; Cell Proliferation; Chronic Disease; Colitis; Dextran Sulfate; Dicarboxylic Acids; Dihydroorotate Dehydrogenase; Disease Models, Animal; Female; Immunoenzyme Techniques; Immunosuppressive Agents; Inflammatory Bowel Diseases; Interleukin-17; Mice; Mice, Inbred BALB C; Oxidoreductases Acting on CH-CH Group Donors; Trinitrobenzenesulfonic Acid | 2010 |
Neuronal nitric oxide inhibits intestinal smooth muscle growth.
Topics: Animals; Cells, Cultured; Coculture Techniques; Colitis; Cyclic GMP; Gene Expression Regulation, Enzymologic; Intestines; Male; Myenteric Plexus; Myocytes, Smooth Muscle; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chimera; Colitis; Colon; Dextran Sulfate; Inflammation; Leukocytes; Mice; Mice, Knockout; Peroxidase; Receptor, PAR-2; Trinitrobenzenesulfonic Acid | 2010 |
Cyclooxygenase-2 inhibitors prevent trinitrobenzene sulfonic acid-induced P-glycoprotein up-regulation in vitro and in vivo.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Caco-2 Cells; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Enzyme Induction; Humans; Indomethacin; Inflammation; Male; Mice; Trinitrobenzenesulfonic Acid; Up-Regulation | 2010 |
Identification of epithelial to mesenchymal transition as a novel source of fibroblasts in intestinal fibrosis.
Topics: Animals; beta-Galactosidase; Bone Morphogenetic Protein 7; Cadherins; Cell Line; Cells, Cultured; Colitis; Colon; Epithelial Cells; Female; Fibroblasts; Fibrosis; Humans; Inflammatory Bowel Diseases; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Intestines; Lac Operon; Male; Mesoderm; Mice; Mice, Inbred C57BL; Mice, Transgenic; Proteins; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Intestinal anti-inflammatory activity of esculetin and 4-methylesculetin in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Colitis; Disease Models, Animal; Glutathione; Male; Peroxidase; Rats; Rats, Wistar; Scopoletin; Structure-Activity Relationship; Sulfasalazine; Trinitrobenzenesulfonic Acid; Umbelliferones | 2010 |
Total alkaloids of Sophora alopecuroides increases the expression of CD4+ CD25+ Tregs and IL-10 in rats with experimental colitis.
Topics: Alkaloids; Animals; Base Sequence; CD4 Antigens; Colitis; Colon; DNA Primers; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Interleukin-10; Interleukin-2 Receptor alpha Subunit; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Sophora; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2010 |
Glutamine prevents fibrosis development in rats with colitis induced by 2,4,6-trinitrobenzene sulfonic acid.
Topics: Animals; Colitis; Fibrosis; Gene Expression Regulation; Glutamine; Inflammation; Interleukin-6; Male; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Rotavirus-like particles: a novel nanocarrier for the gut.
Topics: Analysis of Variance; Animals; Baculoviridae; Cell Line; Colitis; Disease Models, Animal; Drug Delivery Systems; Enzyme-Linked Immunosorbent Assay; Green Fluorescent Proteins; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Nanoparticles; Rotavirus; Spodoptera; Trinitrobenzenesulfonic Acid; Virion; Virus Internalization | 2010 |
Di-D-fructose dianhydride-enriched caramels: effect on colon microbiota, inflammation, and tissue damage in trinitrobenzenesulfonic acid-induced colitic rats.
Topics: Animals; Anti-Inflammatory Agents; Candy; Colitis; Colon; Disaccharides; Disease Models, Animal; Female; Food Handling; Food, Fortified; Glycosylation; Hot Temperature; Oligosaccharides; Prebiotics; Rats; Rats, Wistar; Stereoisomerism; Sucrose; Trinitrobenzenesulfonic Acid | 2010 |
Probiotic yeasts: anti-inflammatory potential of various non-pathogenic strains in experimental colitis in mice.
Topics: Animals; Colitis; Cytokines; Female; Humans; In Vitro Techniques; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Probiotics; Saccharomyces; Trinitrobenzenesulfonic Acid | 2010 |
Expression of interleukin 6 in brain and colon of rats with TNBS-induced colitis.
Topics: Animals; Base Sequence; Brain; Colitis; Colon; Disease Models, Animal; DNA Primers; Female; Gene Expression; Humans; Inflammatory Bowel Diseases; Interleukin-6; Neuroimmunomodulation; Peroxidase; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2010 |
Exosomes derived from interleukin-10-treated dendritic cells can inhibit trinitrobenzene sulfonic acid-induced rat colitis.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Exosomes; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-2; Male; Mucous Membrane; Rats; Rats, Wistar; RNA, Messenger; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Anti-inflammatory effect of enzymatic hydrolysate of corn gluten in an experimental model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon, Descending; Dietary Supplements; Disease Models, Animal; Dose-Response Relationship, Drug; Food, Formulated; Glutens; Histamine; Intestinal Mucosa; Male; Peroxidase; Protein Hydrolysates; Rats; Rats, Sprague-Dawley; Seeds; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Zea mays | 2010 |
Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Colon; Enzyme-Linked Immunosorbent Assay; Immunohistochemistry; Male; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sensory Receptor Cells; Signal Transduction; Substance P; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Urinary Bladder | 2010 |
Skeletal muscle catabolism in trinitrobenzene sulfonic acid-induced murine colitis.
Topics: Animals; Colitis; Inflammation Mediators; Insulin-Like Growth Factor I; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscle, Skeletal; Muscular Atrophy; Proteasome Endopeptidase Complex; Protein Stability; Trinitrobenzenesulfonic Acid | 2010 |
Gut microbial diversity is reduced by the probiotic VSL#3 and correlates with decreased TNBS-induced colitis.
Topics: Animals; Colitis; Male; Metagenome; Probiotics; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota.
Topics: Adoptive Transfer; Animals; Bacteroides fragilis; CD4-Positive T-Lymphocytes; Colitis; Forkhead Transcription Factors; Host-Pathogen Interactions; Humans; Immune Tolerance; Immunity, Mucosal; Interleukin-10; Intestinal Mucosa; Intestines; Lipopolysaccharides; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory; Trinitrobenzenesulfonic Acid | 2010 |
Naphthalen-1-yl-(4-pentyloxynaphthalen-1-yl)methanone (SAB378), a peripherally restricted cannabinoid CB1/CB2 receptor agonist, inhibits gastrointestinal motility but has no effect on experimental colitis in mice.
Topics: Animals; Colitis; Colon; Dextran Sulfate; Female; Gastrointestinal Motility; Gastrointestinal Transit; Male; Mice; Mice, Inbred C57BL; Motor Activity; Naphthalenes; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Trinitrobenzenesulfonic Acid | 2010 |
The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis.
Topics: Animals; Cannabidiol; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Therapy, Combination; Gastrointestinal Motility; In Vitro Techniques; Inflammation; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2010 |
Colonic delivery of carboxyfluorescein by pH-sensitive microspheres in experimental colitis.
Topics: Administration, Oral; Administration, Rectal; Animals; Biological Availability; Colitis; Colon; Disease Models, Animal; Drug Delivery Systems; Fluoresceins; Hydrogen-Ion Concentration; Male; Microspheres; Polymethacrylic Acids; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2010 |
Endothelins implicated in referred mechanical hyperalgesia associated with colitis induced by TNBS in mice.
Topics: Abdominal Pain; Animals; Atrasentan; Colitis; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Foot; Hindlimb; Hyperalgesia; Male; Mice; Mice, Inbred BALB C; Morphine; Pain, Referred; Pyrrolidines; Touch; Trinitrobenzenesulfonic Acid | 2010 |
Mitogenic factors promoting intestinal smooth muscle cell proliferation.
Topics: Animals; Becaplermin; Cell Proliferation; Cells, Cultured; Colitis; Epidermal Growth Factor; Humans; Insulin-Like Growth Factor I; Intercellular Signaling Peptides and Proteins; Intestines; Male; Myocytes, Smooth Muscle; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Receptor, Platelet-Derived Growth Factor beta; Signal Transduction; Trinitrobenzenesulfonic Acid | 2010 |
Enhanced therapeutic effect of LK-423 in treating experimentally induced colitis in rats when administered in colon delivery microcapsules.
Topics: Administration, Oral; Administration, Rectal; Animals; Capsules; Colitis; Colon; Dipeptides; Disease Models, Animal; Drug Delivery Systems; Hydrogen-Ion Concentration; Intestinal Absorption; Intestinal Mucosa; Male; Phthalimides; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2010 |
Arsenic trioxide reduces 2,4,6-trinitrobenzene sulfonic acid-induced murine colitis via nuclear factor-κB down-regulation and caspase-3 activation.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Caspase 3; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Humans; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Oxides; Peroxidase; Trinitrobenzenesulfonic Acid | 2011 |
Protective effects of N(G)-nitro-L-arginine methyl ester and metallothioneins on excess nitric oxide toxicity in trinitrobenzene sulfonic acid-induced rat colitis.
Topics: Animals; Blood Cell Count; Bone Marrow; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Intestinal Mucosa; Male; Metallothionein; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Trinitrobenzenesulfonic Acid | 2010 |
Dietary heme adversely affects experimental colitis in rats, despite heat-shock protein induction.
Topics: Animals; Biomarkers; Colitis; Colon; Enterobacter; Heat-Shock Proteins; Heme; Heme Oxygenase-1; Inflammation; Interleukin-1beta; Intestinal Mucosa; Lactobacillaceae; Male; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Amelioration of excess collagen IαI, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice.
Topics: Animals; Apoptosis; Blotting, Western; Cells, Cultured; Colitis; Collagen Type I; Collagen Type I, alpha 1 Chain; Enzyme-Linked Immunosorbent Assay; Fibrosis; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor Binding Protein 5; Insulin-Like Growth Factor I; Intestines; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2011 |
An α-linolenic acid-rich formula reduces oxidative stress and inflammation by regulating NF-κB in rats with TNBS-induced colitis.
Topics: alpha-Linolenic Acid; Animals; Chymotrypsin; Colitis; Colon; Cytokines; Diet; Dinoprost; Eicosanoids; Erythrocytes; Fatty Acids; Glutathione; Interferons; Male; NF-kappa B; Nitric Oxide Synthase Type II; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
AMPK agonist downregulates innate and adaptive immune responses in TNBS-induced murine acute and relapsing colitis.
Topics: Acute Disease; Adaptive Immunity; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Colitis; Down-Regulation; Enzyme Activation; Female; Immunity, Innate; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Recurrence; Ribonucleotides; Trinitrobenzenesulfonic Acid | 2010 |
Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation.
Topics: Animals; Berberine; Colitis; Enterobacteriaceae; Enzyme Activation; HEK293 Cells; Humans; Inflammation; Intestinal Mucosa; Intestines; Lipid Peroxidation; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Trinitrobenzenesulfonic Acid | 2010 |
Proinflammatory role of vasopressin through V1b receptors in hapten-induced experimental colitis in rodents: implication in IBD.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Colitis; Gene Expression; Gene Expression Regulation; Haptens; Humans; Indoles; Inflammatory Bowel Diseases; Mice; Phosphodiesterase Inhibitors; Pyrrolidines; Rats; Receptors, Vasopressin; Thioxanthenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vasopressins; Water Deprivation; Weight Gain; Xanthones | 2010 |
Adenosine A2A receptors and uric acid mediate protective effects of inosine against TNBS-induced colitis in rats.
Topics: Adenosine A2 Receptor Antagonists; Animals; Biomarkers; Colitis; Dietary Supplements; Drug Synergism; Enzyme Inhibitors; Inflammation Mediators; Inflammatory Bowel Diseases; Inosine Monophosphate; Lipid Peroxidation; Macrophages; Male; Neutrophil Infiltration; Oxonic Acid; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Urate Oxidase; Uric Acid | 2010 |
Substance P modulates colitis-associated fibrosis.
Topics: Animals; Bridged Bicyclo Compounds, Heterocyclic; Cell Line; Cell Movement; Colitis; Collagen; Colon; Fibroblasts; Fibrosis; Humans; Insulin-Like Growth Factor I; Intestinal Mucosa; Mice; Mice, Knockout; Neurokinin-1 Receptor Antagonists; Proto-Oncogene Proteins c-akt; Receptors, Neurokinin-1; Substance P; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Vimentin | 2010 |
Soyasaponin I attenuates TNBS-Induced colitis in mice by inhibiting NF-κB pathway.
Topics: Animals; Colitis; Cyclooxygenase 2; Glycine max; Humans; Interleukin-1; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Plant Extracts; Saponins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2010 |
Variable impact of CD39 in experimental murine colitis.
Topics: Animals; Antigens, CD; Apyrase; Colitis; Colon; Cytokines; Humans; Leukocytes, Mononuclear; Mice; Mice, Knockout; Oxazolone; Specific Pathogen-Free Organisms; Trinitrobenzenesulfonic Acid | 2011 |
Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Transformation, Neoplastic; Colitis; Colonic Neoplasms; Disease Models, Animal; Disease Progression; Immunohistochemistry; Male; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2010 |
Differential immune and genetic responses in rat models of Crohn's colitis and ulcerative colitis.
Topics: Animals; Colitis; Colitis, Ulcerative; Crohn Disease; Cytokines; Dextran Sulfate; Disease Models, Animal; Hyperplasia; Hypertrophy; Inflammation; Inflammation Mediators; Muscle, Smooth; Oxidative Stress; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Bone marrow stromal cell transplants prevent experimental enterocolitis and require host CD11b+ splenocytes.
Topics: Adoptive Transfer; Animals; Bone Marrow Transplantation; CD11b Antigen; Cell Communication; Cell Tracking; Coculture Techniques; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunophenotyping; Interleukin-2 Receptor alpha Subunit; Lymph Nodes; Male; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Phenotype; Spleen; Stromal Cells; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Enteral diets enriched with medium-chain triglycerides and N-3 fatty acids prevent chemically induced experimental colitis in rats.
Topics: Animal Feed; Animals; Body Weight; Chemokines; Colitis; Colon; Disease Models, Animal; Endotoxemia; Endotoxins; Enema; Enteral Nutrition; Fatty Acids, Omega-3; Male; Peroxidase; Rats; Rats, Wistar; Triglycerides; Trinitrobenzenesulfonic Acid | 2010 |
3,3'-Diindolylmethane decreases VCAM-1 expression and alleviates experimental colitis via a BRCA1-dependent antioxidant pathway.
Topics: Animals; Antioxidants; Blotting, Western; BRCA1 Protein; Cell Adhesion; Colitis; Endothelium, Vascular; Female; Fluorescent Antibody Technique; Humans; Indoles; Leukocytes; Mice; Mice, Inbred BALB C; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 2011 |
[Pathogenetic mechanism of beta-arrestin1 in experimental colitis of rats and intervention effects of oxymatrine].
Topics: Alkaloids; Animals; Arrestins; beta-Arrestins; Colitis; Colon; Inflammatory Bowel Diseases; Male; Proto-Oncogene Proteins c-bcl-2; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Signal Transduction; Trinitrobenzenesulfonic Acid | 2010 |
Anti-inflammatory effects of iridoid glycosides fraction of Folium syringae leaves on TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents; Base Sequence; Colitis; DNA Primers; Drugs, Chinese Herbal; Ethnopharmacology; Gene Expression; Glycosides; Interleukin-6; Iridoid Glycosides; Male; Malondialdehyde; Peroxidase; Phytotherapy; Plant Leaves; Plants, Medicinal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Syringa; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
The correlation between NF-κB inhibition and disease activity by coadministration of silibinin and ursodeoxycholic acid in experimental colitis.
Topics: Animals; Antioxidants; Cholagogues and Choleretics; Colitis; Dexamethasone; Disease Models, Animal; Drug Therapy, Combination; Male; NF-kappa B; Rats; Rats, Wistar; Silybin; Silymarin; Trinitrobenzenesulfonic Acid; Ursodeoxycholic Acid | 2011 |
Dietary polydextrose prevents inflammatory bowel disease in trinitrobenzenesulfonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Drug Interactions; Gastrointestinal Agents; Glucans; Glutathione; Inflammatory Bowel Diseases; Male; Organ Size; Oxidative Stress; Peroxidase; Prebiotics; Random Allocation; Rats; Rats, Wistar; Severity of Illness Index; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2010 |
Blockade of complement activation product C5a activity using specific antibody attenuates intestinal damage in trinitrobenzene sulfonic acid induced model of colitis.
Topics: Animals; Antibodies, Neutralizing; Colitis; Colon; Complement Activation; Complement C5a; Cytokines; Humans; Immunotherapy; Inflammatory Bowel Diseases; Intestinal Mucosa; Lymphocyte Count; Male; Mice; Mice, Inbred BALB C; Neutrophil Infiltration; Receptor, Anaphylatoxin C5a; RNA, Messenger; Severity of Illness Index; Th2 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Anti-colitis and -adhesion effects of daikenchuto via endogenous adrenomedullin enhancement in Crohn's disease mouse model.
Topics: Adrenomedullin; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Adhesion; Cell Line; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Flow Cytometry; Gene Expression; Immunohistochemistry; Interferon-gamma; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Panax; Phytotherapy; Plant Extracts; Rats; Serum Amyloid A Protein; Treatment Outcome; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation; Zanthoxylum; Zingiberaceae | 2010 |
Effects of recombinant human intestinal trefoil factor on trinitrobenzene sulphonic acid induced colitis in rats.
Topics: Animals; Colitis; Epidermal Growth Factor; Male; NF-kappa B; Peptides; Peroxidase; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Time Factors; Trefoil Factor-2; Trinitrobenzenesulfonic Acid | 2011 |
The intestinal anti-inflammatory effect of minocycline in experimental colitis involves both its immunomodulatory and antimicrobial properties.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Line; Colitis; Dextran Sulfate; Female; Humans; Immunologic Factors; Inflammatory Bowel Diseases; Macrophages; Mice; Mice, Inbred C57BL; Minocycline; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Modulation of visceral hypersensitivity by glial cell line-derived neurotrophic factor family receptor α-3 in colorectal afferents.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Electromyography; Evoked Potentials; Ganglia, Spinal; Glial Cell Line-Derived Neurotrophic Factor Receptors; Hyperalgesia; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurons, Afferent; Pressure; Rectum; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Calcineurin inhibition by polaprezinc in rats with experimentally-induced colitis.
Topics: Administration, Rectal; Animals; Anti-Ulcer Agents; Calcineurin; Calcineurin Inhibitors; Carnosine; Cell Survival; Colitis; Cytokines; Disease Models, Animal; Gene Expression; Humans; Interleukin-2; Intestinal Mucosa; Jurkat Cells; Male; NFATC Transcription Factors; Organometallic Compounds; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Zinc Compounds | 2011 |
Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells.
Topics: Animals; Apoptosis; CD4 Antigens; Cells, Cultured; Colitis; Colon; Cytokines; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Intestinal Mucosa; Male; Matrix Metalloproteinase 9; Mice; Neutrophil Infiltration; Neutrophils; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Quinoxalines; T-Lymphocytes, Regulatory; Thiazolidinediones; Trinitrobenzenesulfonic Acid; Vascular Endothelial Growth Factor A | 2011 |
Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-κB-inducible immune pathways.
Topics: Animals; Cell Line; Colitis; Dextran Sulfate; Erythropoietin; Humans; Inflammation Mediators; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Nitric Oxide; Receptors, Erythropoietin; Salmonella; Salmonella Infections; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Treatment with Bifidobacterium bifidum 17 partially protects mice from Th1-driven inflammation in a chemically induced model of colitis.
Topics: Animals; Bifidobacterium; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Inflammation Mediators; Inflammatory Bowel Diseases; Interleukin-1beta; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Probiotics; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2011 |
Blocking TNF-α by combination of TNF-α- and TNFR-binding cyclic peptide ameliorates the severity of TNBS-induced colitis in rats.
Topics: Animals; Colitis; Colon; Gene Expression Regulation; Humans; Inflammation; Interleukin-1beta; Interleukin-8; Leukocytes; Male; Nitric Oxide; Peptide Library; Peptides, Cyclic; Peroxidase; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor, Type I; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Proliferation modulates intestinal smooth muscle phenotype in vitro and in colitis in vivo.
Topics: Animals; Becaplermin; Biomarkers; Blotting, Western; Cell Proliferation; Colitis; Flow Cytometry; Immunohistochemistry; Mitogens; Mitosis; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Phenotype; Phosphorylation; Platelet-Derived Growth Factor; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2011 |
Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2.
Topics: Animals; Blotting, Western; Colitis; Disease Progression; Edema; Extracellular Signal-Regulated MAP Kinases; Immunohistochemistry; Kinetics; Male; Peroxidase; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Messenger; Signal Transduction; Trinitrobenzenesulfonic Acid; Urocortins | 2011 |
Perinodal adipose tissue and mesenteric lymph node activation during reactivated TNBS-colitis in rats.
Topics: Adipokines; Adipose Tissue; Animals; Arachidonic Acid; bcl-2-Associated X Protein; Colitis; Cyclooxygenase 2; Gene Expression Regulation; Inflammation; Interferon-gamma; Lymph Nodes; Male; Mesentery; Peroxidase; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Bojanggunbi-tang, a traditional Korean herbal prescription, ameliorates colonic inflammation induced by dextran sulfate sodium and 2,4,6-trinitrobenzene sulfonic acid in mice.
Topics: Animals; Colitis; Dextran Sulfate; Medicine, Traditional; Mice; Trinitrobenzenesulfonic Acid | 2011 |
Human umbilical cord mesenchymal stem cells ameliorate mice trinitrobenzene sulfonic acid (TNBS)-induced colitis.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Separation; Cell Survival; Coculture Techniques; Colitis; Colon; Cytokines; Humans; Immunophenotyping; Inflammation Mediators; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Microscopy, Fluorescence; Mucous Membrane; Spleen; Trinitrobenzenesulfonic Acid; Umbilical Cord | 2011 |
Chronic lithium administration ameliorates 2,4,6-trinitrobenzene sulfonic acid-induced colitis in rats; potential role for adenosine triphosphate sensitive potassium channels.
Topics: Adenosine Triphosphate; Animals; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Follow-Up Studies; Intestinal Mucosa; Lithium; Male; Potassium Channels; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Klebsiella pneumoniae increases the risk of inflammation and colitis in a murine model of intestinal bowel disease.
Topics: Animals; Biomarkers; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Klebsiella Infections; Klebsiella pneumoniae; Lactobacillus; Lipid Peroxidation; Lipopolysaccharides; Male; Mice; Mice, Inbred ICR; Trinitrobenzenesulfonic Acid | 2011 |
Targeting IL-12/IL-23 by employing a p40 peptide-based vaccine ameliorates TNBS-induced acute and chronic murine colitis.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Collagen; Colon; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Fibrosis; Gene Expression; Immunoglobulin G; Interleukin-12 Subunit p40; Lymph Nodes; Mesentery; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; Vaccines, Subunit; Weight Loss | 2011 |
The relationship between inflammation-induced neuronal excitability and disrupted motor activity in the guinea pig distal colon.
Topics: Animals; Colitis; Colon; Enteric Nervous System; Gastrointestinal Motility; Guinea Pigs; Indoles; Models, Animal; Motor Activity; Myenteric Plexus; Pyrazoles; Pyrimidines; Trinitrobenzenesulfonic Acid; Veratridine | 2011 |
Acute colonic inflammation triggers detrusor instability via activation of TRPV1 receptors in a rat model of pelvic organ cross-sensitization.
Topics: Acute Disease; Animals; Carbachol; Cholinergic Agents; Colitis; Diterpenes; Electric Stimulation; Male; Models, Animal; Muscle Contraction; Pelvic Pain; Rats; Rats, Sprague-Dawley; Signal Transduction; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Urinary Bladder; Urinary Bladder, Overactive | 2011 |
The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.
Topics: Animals; Antigens, Helminth; Colitis; Colon; Cytokines; Disease Models, Animal; Helminth Proteins; Immunoglobulin G; Immunomodulation; Injections, Subcutaneous; Male; Mice; Mice, Inbred BALB C; Recombinant Proteins; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2011 |
Extracellular matrix protein lumican regulates inflammation in a mouse model of colitis.
Topics: Animals; Blotting, Western; Chondroitin Sulfate Proteoglycans; Colitis; Cytokines; Disease Models, Animal; Electrophoretic Mobility Shift Assay; Female; Flow Cytometry; Haptens; Inflammation; Keratan Sulfate; Lipopolysaccharides; Lumican; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Influence of Shenqing Recipe on morphology and quantity of colonic interstitial cells of Cajal in trinitrobenzene sulfonic acid induced rat colitis.
Topics: Animals; Colitis; Colon; Drugs, Chinese Herbal; Interstitial Cells of Cajal; Male; Medicine, Chinese Traditional; Mesalamine; Peroxidase; Proto-Oncogene Proteins c-kit; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Colitis decreases mechanosensitive K2P channel expression and function in mouse colon sensory neurons.
Topics: Animals; Cells, Cultured; Colitis; Colon; Ganglia, Spinal; Gene Expression; Male; Mechanotransduction, Cellular; Membrane Potentials; Mice; Mice, Inbred C57BL; Potassium Channels, Tandem Pore Domain; Sensory Receptor Cells; Splanchnic Nerves; Trinitrobenzenesulfonic Acid | 2011 |
Upregulation of 11β-hydroxysteroid dehydrogenase 1 in lymphoid organs during inflammation in the rat.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Animals; Colitis; Colon; Interleukin-1beta; Lymph Nodes; Male; Mesentery; Rats; Rats, Wistar; RNA, Messenger; Spleen; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation.
Topics: Animals; Arachidonic Acids; Benzodioxoles; Colitis; Disease Models, Animal; Endocannabinoids; Endotoxemia; Enzyme Inhibitors; Glycerides; Humans; Indoles; Inflammation; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred C57BL; Monoacylglycerol Lipases; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Trinitrobenzenesulfonic Acid | 2011 |
The effect of pentoxifylline and its metabolite-1 on inflammation and fibrosis in the TNBS model of colitis.
Topics: Animals; Colitis; Collagen Type I; Colon; Disease Models, Animal; Female; Fibrosis; Inflammation; Interleukin-18; Intestinal Mucosa; Intestines; Organ Size; Pentoxifylline; Peroxidase; Rats; Rats, Sprague-Dawley; Stereoisomerism; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Development of non-antibiotic macrolide that corrects inflammation-driven immune dysfunction in models of inflammatory bowel diseases and arthritis.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Azithromycin; CD11b Antigen; Colitis; Collagen; Dextran Sulfate; Disease Models, Animal; Drug Discovery; Female; Humans; Immunologic Factors; Inflammation; Inflammatory Bowel Diseases; Male; Mice; Mucous Membrane; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid | 2011 |
Mitochondria-dependent apoptosis of activated T lymphocytes induced by astin C, a plant cyclopeptide, for preventing murine experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Aster Plant; Cells, Cultured; Colitis; Cytokines; Endoplasmic Reticulum Chaperone BiP; Female; Gene Expression Regulation; Mice; Mice, Inbred C57BL; Mitochondria; Peptides, Cyclic; Plant Roots; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2011 |
Ginsenoside Rb1 and its metabolite compound K inhibit IRAK-1 activation--the key step of inflammation.
Topics: Animals; Colitis; Enzyme Inhibitors; Ginsenosides; Inflammation; Interleukin-1 Receptor-Associated Kinases; Male; Mice; Mice, Inbred ICR; Molecular Structure; Panax; Trinitrobenzenesulfonic Acid | 2011 |
Involvement of tyrosine kinase-2 in both the IL-12/Th1 and IL-23/Th17 axes in vivo.
Topics: Adjuvants, Immunologic; Aminoquinolines; Animals; Cell Differentiation; Colitis; Dextran Sulfate; Drug Delivery Systems; Hypersensitivity, Delayed; Imiquimod; Interleukin-12; Interleukin-23; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Psoriasis; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid; TYK2 Kinase | 2011 |
Enteric neuronal density contributes to the severity of intestinal inflammation.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carrier Proteins; Colitis; Dextran Sulfate; Dinitrofluorobenzene; Enteric Nervous System; Female; Hypersensitivity, Delayed; Interferon-gamma; Interleukin-1beta; Leukocyte Elastase; Male; Mice; Neurons; Neutrophils; NF-kappa B p50 Subunit; Severity of Illness Index; Survival; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Expression level of Hand2 affects specification of enteric neurons and gastrointestinal function in mice.
Topics: Animals; Apoptosis; Basic Helix-Loop-Helix Transcription Factors; Calbindin 2; Cell Count; Colitis; Colon; ELAV Proteins; ELAV-Like Protein 2; ELAV-Like Protein 3; ELAV-Like Protein 4; Enteric Nervous System; Gastrointestinal Motility; Genotype; Intercellular Junctions; Mice; Muscle, Smooth; Neuroglia; Neurons; Nitric Oxide Synthase; S100 Calcium Binding Protein G; Substance P; Synaptic Transmission; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2011 |
The study of biochemical and histopathological effects of spirulina in rats with TNBS-induced colitis.
Topics: Animals; Antioxidants; Colitis; Colon; Intestinal Mucosa; Lipid Peroxidation; Rats; Rats, Wistar; Spirulina; Trinitrobenzenesulfonic Acid | 2011 |
Inhibition of colitis by IL-25 associates with induction of alternatively activated macrophages.
Topics: Analysis of Variance; Animals; Antibodies, Neutralizing; Antigens, Differentiation; Arginase; beta-N-Acetylhexosaminidases; Cell Count; Colitis; Gene Expression; Intercellular Signaling Peptides and Proteins; Interleukin-13; Interleukin-17; Interleukin-4; Intestinal Mucosa; Lectins; Macrophage Activation; Macrophages, Peritoneal; Mice; Statistics, Nonparametric; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2012 |
N-Succinyl-chitosan systems for 5-aminosalicylic acid colon delivery: in vivo study with TNBS-induced colitis model in rats.
Topics: Absorption; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Drug Delivery Systems; Freeze Drying; Intestinal Mucosa; Lymphocyte Activation; Male; Mesalamine; Organ Size; Peroxidase; Polymers; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Therapeutic effect of antisecretory factor-rich egg yolk on the late phases of 2,4,6-trinitrobenzenesulphonic acid colitis in mice.
Topics: Animals; Colitis; Egg Yolk; Female; Mice; Mice, Inbred BALB C; Neuropeptides; Trinitrobenzenesulfonic Acid | 2011 |
The atypical cannabinoid O-1602 protects against experimental colitis and inhibits neutrophil recruitment.
Topics: Analysis of Variance; Animals; Cannabidiol; Cannabinoids; Chemotaxis, Leukocyte; Colitis; Colon; Cyclohexanes; Dextran Sulfate; Disease Models, Animal; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; Neutrophil Infiltration; Neutrophils; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Resorcinols; Trinitrobenzenesulfonic Acid | 2011 |
Impaired integrity of DNA after recovery from inflammation causes persistent dysfunction of colonic smooth muscle.
Topics: Acetylcholine; Animals; Calcium Channels, L-Type; Colitis; Colon; Disease Models, Animal; DNA Damage; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hydrogen Peroxide; Inflammatory Bowel Diseases; Intestinal Mucosa; Isothiocyanates; Male; Muscle, Smooth; NF-E2-Related Factor 2; Oxidative Stress; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Sulfoxides; Thiocyanates; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
Protective effects of glycyrrhizic acid by rectal treatment on a TNBS-induced rat colitis model.
Topics: Administration, Oral; Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Glycyrrhizic Acid; Interleukin-10; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Rats; Rats, Wistar; Spleen; Trinitrobenzenesulfonic Acid | 2011 |
Neuroimmunomodulative properties of dipeptidyl peptidase IV/CD26 in a TNBS-induced model of colitis in mice.
Topics: Animals; Blotting, Western; Colitis; Dipeptidyl Peptidase 4; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Interleukins; Mice; Mice, Knockout; Neuropeptide Y; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2011 |
The PepT1-NOD2 signaling pathway aggravates induced colitis in mice.
Topics: Actins; Animals; Anti-Bacterial Agents; Bone Marrow Transplantation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Humans; Inflammation Mediators; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microfilament Proteins; Nod2 Signaling Adaptor Protein; Peptide Transporter 1; Promoter Regions, Genetic; Severity of Illness Index; Signal Transduction; Symporters; Time Factors; Trinitrobenzenesulfonic Acid | 2011 |
TRPA1 and substance P mediate colitis in mice.
Topics: Aldehydes; Animals; Calcitonin Gene-Related Peptide; Calcium; Calcium Channels; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes; Ganglia, Spinal; HEK293 Cells; Humans; Inflammation Mediators; Lipid Peroxidation; Membrane Potentials; Mice; Mice, Knockout; Mutation; Nerve Tissue Proteins; Patch-Clamp Techniques; Substance P; Transfection; Transient Receptor Potential Channels; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPV Cation Channels | 2011 |
Repeated enemas with hepatocyte growth factor selectively stimulate epithelial cell proliferation of injured mucosa in rats with experimental colitis.
Topics: Administration, Rectal; Animals; Cell Proliferation; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Rats; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 2011 |
Biochemical and pathological evidences on the benefit of a new biodegradable nanoparticles of probiotic extract in murine colitis.
Topics: Animals; Chitosan; Colitis; Cytokines; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Freeze Drying; Inflammation Mediators; Lactic Acid; Lipid Peroxidation; Male; Nanoparticles; Pilot Projects; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Sildenafil attenuates TNBS-induced colitis in rats: possible involvement of cGMP and KATP channels.
Topics: Animals; Colitis; Cyclic GMP; Disease Models, Animal; Glyburide; KATP Channels; Male; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Trinitrobenzenesulfonic Acid | 2012 |
Ultrasound elasticity imaging for detecting intestinal fibrosis and inflammation in rats and humans with Crohn's disease.
Topics: Animals; Biomechanical Phenomena; Colitis; Colon; Crohn Disease; Diagnosis, Differential; Diagnostic Imaging; Disease Models, Animal; Disease Progression; Elasticity; Female; Fibrosis; Humans; Inflammation; Inflammatory Bowel Diseases; Intestine, Small; Pilot Projects; Rats; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid; Ultrasonography | 2011 |
The intestinal anti-inflammatory effect of dersalazine sodium is related to a down-regulation in IL-17 production in experimental models of rodent colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Azo Compounds; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Down-Regulation; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Platelet Activating Factor; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
The effect of phosphodiesterase-5 inhibition by sildenafil citrate on inflammation and apoptosis in rat experimental colitis.
Topics: Animals; Apoptosis; Colitis; Female; Glutathione; Inflammatory Bowel Diseases; Interleukin-10; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Peroxidase; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sildenafil Citrate; Sulfones; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Daikenchuto (TU-100) ameliorates colon microvascular dysfunction via endogenous adrenomedullin in Crohn's disease rat model.
Topics: Adrenomedullin; Amides; Animals; Calcitonin Gene-Related Peptide; Cell Line; Colitis; Colon; Crohn Disease; Disease Models, Animal; Intestinal Mucosa; Male; Microvessels; Panax; Plant Extracts; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; Up-Regulation; Vasodilation; Zanthoxylum; Zingiberaceae | 2011 |
Probiotics modulate intestinal expression of nuclear receptor and provide counter-regulatory signals to inflammation-driven adipose tissue activation.
Topics: Adipose Tissue; Adult; Animals; Blotting, Western; Cells, Cultured; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoenzyme Techniques; Inflammation; Intestinal Mucosa; Intestines; Liver X Receptors; Male; Mesentery; Mice; Orphan Nuclear Receptors; PPAR gamma; Pregnane X Receptor; Probiotics; Receptors, Cytoplasmic and Nuclear; Receptors, Steroid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2011 |
BTZO-15, an ARE-activator, ameliorates DSS- and TNBS-induced colitis in rats.
Topics: Animals; Antioxidants; Cell Death; Colitis; Dextran Sulfate; Gene Expression Regulation; Glutathione Transferase; Heme Oxygenase-1; Humans; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Nitric Oxide; Protein Binding; Pyridines; Rats; Rectum; Response Elements; RNA, Messenger; Thiazines; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2011 |
The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats.
Topics: Animals; Colitis; Colonoscopy; Disease Models, Animal; Female; Follow-Up Studies; Intestinal Mucosa; Rats; Rats, Wistar; Reproducibility of Results; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2011 |
The effect of stinging nettle (Urtica dioica) seed oil on experimental colitis in rats.
Topics: Administration, Oral; Animals; Antioxidants; Cholesterol; Colitis; Colon; Disease Models, Animal; Female; Glutathione; Inflammation; Interleukin-6; L-Lactate Dehydrogenase; Male; Malondialdehyde; N-Acetylneuraminic Acid; Oxidative Stress; Peroxidase; Plant Oils; Rats; Rats, Wistar; Seeds; Superoxide Dismutase; Triglycerides; Trinitrobenzenesulfonic Acid; Urtica dioica | 2011 |
Etanercept attenuates TNBS-induced experimental colitis: role of TNF-α expression.
Topics: Animals; Body Weight; Colitis; Colon; Etanercept; Gene Expression Regulation; Immunoglobulin G; Immunohistochemistry; Male; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Staining and Labeling; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2011 |
Hyaluronic acid as a rescue therapy for trinitrobenzene sulfonic acid-induced colitis through Cox-2 and PGE2 in a Toll-like receptor 4-dependent way.
Topics: Animals; Colitis; Cyclooxygenase 2; Dinoprostone; Female; Hyaluronic Acid; Immunohistochemistry; Macrophages, Peritoneal; Mice; Mice, Inbred C3H; Microscopy, Fluorescence; Toll-Like Receptor 4; Toll-Like Receptors; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2011 |
On the benefit of whey-cultured Lactobacillus casei in murine colitis.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dexamethasone; Disease Models, Animal; Ethanol; Lacticaseibacillus casei; Lipid Peroxidation; Male; Mice; Milk Proteins; Peroxidase; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Whey Proteins | 2011 |
Antibiotic treatment with ampicillin accelerates the healing of colonic damage impaired by aspirin and coxib in the experimental colitis. Importance of intestinal bacteria, colonic microcirculation and proinflammatory cytokines.
Topics: Ampicillin; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Bacterial Load; Bacterial Translocation; Celecoxib; Chemokines; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Enterococcus; Escherichia coli; Feces; Humans; Intestinal Mucosa; Intestines; Male; Microcirculation; Peroxidase; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2011 |
Pretreatment with interferon-γ enhances the therapeutic activity of mesenchymal stromal cells in animal models of colitis.
Topics: Animals; Body Weight; Cell Differentiation; Cell Movement; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Humans; Immunity, Cellular; Immunosuppression Therapy; Injections, Intraperitoneal; Interferon-gamma; Intestinal Mucosa; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Serum Amyloid A Protein; Trinitrobenzenesulfonic Acid | 2011 |
Amelioration of 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice by immunoregulatory dendritic cells.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Flow Cytometry; Ileitis; Inflammation; Mice; Mice, Inbred BALB C; Receptors, Immunologic; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2011 |
Apple flavonoid phloretin inhibits Escherichia coli O157:H7 biofilm formation and ameliorates colon inflammation in rats.
Topics: Animals; Bacterial Adhesion; Biofilms; Colitis; Escherichia coli Infections; Escherichia coli O157; HT29 Cells; Humans; Malus; Molecular Structure; Phloretin; Rats; Trinitrobenzenesulfonic Acid | 2011 |
Salvinorin A has antiinflammatory and antinociceptive effects in experimental models of colitis in mice mediated by KOR and CB1 receptors.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Blotting, Western; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Diterpenes, Clerodane; Gastrointestinal Motility; Male; Mice; Naltrexone; Pain; Peroxidase; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid, kappa; Salvia; Trinitrobenzenesulfonic Acid | 2012 |
The water-soluble extract from cultured medium of Ganoderma lucidum (Reishi) mycelia (Designated as MAK) ameliorates murine colitis induced by trinitrobenzene sulphonic acid.
Topics: Animals; Anti-Inflammatory Agents; Antibodies, Monoclonal; Cells, Cultured; Colitis; Colon; Culture Media; Disease Models, Animal; Drugs, Chinese Herbal; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interferon-gamma; Macrophages, Peritoneal; Mice; Mice, Inbred C57BL; Mycelium; Reishi; Trinitrobenzenesulfonic Acid | 2011 |
Antagonism of protease-activated receptor 2 protects against experimental colitis.
Topics: Animals; Body Weight; Calcium Signaling; Colitis; Colon; Cytokines; Edema; HT29 Cells; Humans; Indenes; Intestinal Mucosa; Male; Oligopeptides; Piperazines; Piperidines; Rats; Rats, Wistar; Receptor, PAR-2; Sulfasalazine; Survival Rate; Transendothelial and Transepithelial Migration; Trinitrobenzenesulfonic Acid; Tryptases; Ulcer | 2012 |
Daikenchuto, a Kampo medicine, regulates intestinal fibrosis associated with decreasing expression of heat shock protein 47 and collagen content in a rat colitis model.
Topics: Animals; Colitis; Collagen Type I; Colon; Disease Models, Animal; Fibrosis; Gastrointestinal Agents; HSP47 Heat-Shock Proteins; Intestinal Mucosa; Male; Medicine, Kampo; Panax; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Ulcer; Zanthoxylum; Zingiberaceae | 2011 |
Ameliorating effects of short-chain inulin-like fructans on the healing stage of trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Bacteria; Colitis; Diet; Fructans; Immunoglobulin A; Inulin; Male; Peroxidase; Polymerization; Rats; Rats, Sprague-Dawley; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2011 |
Soyasaponin Ab ameliorates colitis by inhibiting the binding of lipopolysaccharide (LPS) to Toll-like receptor (TLR)4 on macrophages.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Saponins; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2011 |
Coated chitosan pellets containing rutin intended for the treatment of inflammatory bowel disease: in vitro characteristics and in vivo evaluation.
Topics: Administration, Oral; Alginates; Animals; Anti-Inflammatory Agents; Buffers; Caffeic Acids; Chemistry, Pharmaceutical; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Compounding; Drug Implants; Drug Stability; Gastrointestinal Agents; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Hypromellose Derivatives; Male; Methylcellulose; Rats; Rats, Wistar; Rutin; Solubility; Technology, Pharmaceutical; Time Factors; Trinitrobenzenesulfonic Acid; Zinc Acetate | 2012 |
Spironolactone and colitis: increased mortality in rodents and in humans.
Topics: Animals; Clostridioides difficile; Clostridium Infections; Colitis; Crohn Disease; Female; Fibrosis; Hospitalization; Humans; Inflammation; Intestinal Diseases; Male; Middle Aged; Mineralocorticoid Receptor Antagonists; Myofibroblasts; Rats; Retrospective Studies; Spironolactone; Survival Rate; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2012 |
Jα33+ MAIT cells play a protective role in TNBS induced intestinal inflammation.
Topics: Adoptive Transfer; Animals; Antibodies; Colitis; Colon; Disease Models, Animal; Immunity, Mucosal; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Receptors, Antigen, T-Cell, alpha-beta; RNA, Messenger; Severity of Illness Index; Spleen; T-Lymphocyte Subsets; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
Suppression of TNBS-induced colitis in rats by 4-methylesculetin, a natural coumarin: comparison with prednisolone and sulphasalazine.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Apoptosis; Cell Line; Colitis; Coumarins; Cytokines; Gene Expression Regulation; Glutathione; Humans; Male; Malondialdehyde; Matrix Metalloproteinase 9; Mice; Peroxidase; Prednisolone; Rats; Rats, Wistar; Recurrence; Sulfasalazine; Trinitrobenzenesulfonic Acid; Umbelliferones | 2012 |
Schistosoma japonicum ova maintains epithelial barrier function during experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Intestinal Mucosa; Membrane Proteins; Mice; Mice, Inbred BALB C; Nod2 Signaling Adaptor Protein; Occludin; Ovum; Phosphoproteins; Random Allocation; Schistosoma japonicum; Tight Junctions; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2011 |
The effect of progesterone in the prevention of the chemically induced experimental colitis in rats.
Topics: Animals; Apoptosis; Colitis; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Intestinal Mucosa; Male; Malondialdehyde; Nitric Oxide; Progesterone; Progestins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Gene expression profiling identifies mechanisms of protection to recurrent trinitrobenzene sulfonic acid colitis mediated by probiotics.
Topics: Animals; Biomarkers; Chemokines; Colitis; Cytokines; Disease Models, Animal; Female; Gene Expression Profiling; Immunoenzyme Techniques; Inflammation; Mast Cells; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Probiotics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Secondary Prevention; Trinitrobenzenesulfonic Acid | 2012 |
Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model.
Topics: Animals; Cell Line; Cell Proliferation; Colitis; Colon; Colonic Neoplasms; Disease Models, Animal; Disease Progression; ErbB Receptors; Erlotinib Hydrochloride; Humans; Male; Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Quinazolines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2011 |
Osteopontin ablation attenuates progression of colitis in TNBS model.
Topics: Animals; Biopsy, Needle; Colitis; Disease Models, Animal; Disease Progression; Flow Cytometry; Immunohistochemistry; Inflammation Mediators; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Osteopontin; Random Allocation; Reference Values; Sensitivity and Specificity; Serum Amyloid A Protein; Trinitrobenzenesulfonic Acid | 2012 |
Ginsenoside Rd attenuates the inflammatory response via modulating p38 and JNK signaling pathways in rats with TNBS-induced relapsing colitis.
Topics: Animals; Body Weight; Colitis; Colon; Down-Regulation; Ginsenosides; Interleukin-1beta; Interleukin-6; Leukocytes; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Selective glucocorticoid receptor agonists for the treatment of inflammatory bowel disease: studies in mice with acute trinitrobenzene sulfonic acid colitis.
Topics: Acute Disease; Animals; Benzofurans; Benzoxazines; Caco-2 Cells; Cells, Cultured; Colitis; HEK293 Cells; Humans; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Receptors, Glucocorticoid; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2012 |
Magnetic resonance colonography in rats with TNBS-induced colitis: a feasibility and validation study.
Topics: Animals; Blotting, Western; Colitis; Colonoscopy; Cyclooxygenase 2; Cytokines; Disease Models, Animal; Feasibility Studies; Inflammation Mediators; Intestinal Mucosa; Magnetic Resonance Imaging; Male; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Trinitrobenzenesulfonic Acid | 2012 |
Losartan reduces trinitrobenzene sulphonic acid-induced colorectal fibrosis in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Colitis; Disease Models, Animal; Disease Progression; Down-Regulation; Fibrosis; Intestinal Mucosa; Losartan; Male; Rats; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2012 |
Chemically induced mouse models of colitis.
Topics: Animal Husbandry; Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2009 |
Methods of inducing inflammatory bowel disease in mice.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Helicobacter Infections; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; Specimen Handling; Trinitrobenzenesulfonic Acid | 2009 |
Prevention of trinitrobenzene sulfonic acid-induced experimental colitis by oral administration of a poly(lactic-coglycolic acid) microsphere containing prostaglandin E₂ receptor subtype 4 agonist.
Topics: Administration, Oral; Animals; Apoptosis; CD4-Positive T-Lymphocytes; Cell Proliferation; Colitis; Colon; Cytokines; DNA, Single-Stranded; Epithelial Cells; Female; Forkhead Transcription Factors; Interleukin-2 Receptor alpha Subunit; Lactic Acid; Mice; Mice, Inbred BALB C; Microspheres; Mucous Membrane; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Receptors, Prostaglandin E, EP4 Subtype; Trinitrobenzenesulfonic Acid | 2012 |
A novel NF-κB inhibitor, dehydroxymethylepoxyquinomicin, ameliorates inflammatory colonic injury in mice.
Topics: Animals; Benzamides; CD4-Positive T-Lymphocytes; Chemokine CCL2; Colitis; Cyclohexanones; Cytokines; Dextran Sulfate; HT29 Cells; Humans; Interleukin-12 Subunit p40; Interleukin-17; Interleukin-1beta; Interleukin-6; Interleukin-8; Macrophages; Male; Mice; Mice, Inbred C57BL; NF-kappa B; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Up-regulation of brain-derived neurotrophic factor in primary afferent pathway regulates colon-to-bladder cross-sensitization in rat.
Topics: Analysis of Variance; Animals; Antibodies, Neutralizing; Brain-Derived Neurotrophic Factor; Colitis; Colon; Disease Models, Animal; Diterpenes; Drug Administration Schedule; Drug Delivery Systems; Ganglia, Spinal; Male; Neurotoxins; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Ubiquitin Thiolesterase; Up-Regulation; Urinary Bladder; Urination | 2012 |
BMP signaling in rats with TNBS-induced colitis following BMP7 therapy.
Topics: Animals; Bone Morphogenetic Protein 2; Bone Morphogenetic Protein 4; Bone Morphogenetic Protein 6; Bone Morphogenetic Protein 7; Bone Morphogenetic Protein Receptors, Type I; Bone Morphogenetic Protein Receptors, Type II; Carrier Proteins; Colitis; Connective Tissue Growth Factor; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad Proteins; Trinitrobenzenesulfonic Acid | 2012 |
β-Casein hydrolysate generated by the cell envelope-associated proteinase of Lactobacillus delbrueckii ssp. lactis CRL 581 protects against trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Antimutagenic Agents; Caseins; Colitis; Disease Models, Animal; Female; Glucuronidase; Lactobacillus delbrueckii; Mice; Mice, Inbred BALB C; Mutagenicity Tests; Peroxidase; Protein Hydrolysates; Trinitrobenzenesulfonic Acid | 2012 |
Apple polyphenols extract (APE) improves colon damage in a rat model of colitis.
Topics: Animals; Calpain; Colitis; Cyclooxygenase 2; GTP-Binding Proteins; Intestinal Mucosa; Male; Malus; Mice; NIH 3T3 Cells; Phytotherapy; Plant Extracts; Polyphenols; Protein Glutamine gamma Glutamyltransferase 2; Rabbits; Rats, Wistar; RNA, Messenger; Transglutaminases; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
1,3-Diphenylpropenone ameliorates TNBS-induced rat colitis through suppression of NF-κB activation and IL-8 induction.
Topics: Animals; Cell Adhesion; Cell Survival; Chalcones; Colitis; HT29 Cells; Humans; Immunohistochemistry; Inflammation; Interleukin-6; Interleukin-8; Neovascularization, Pathologic; NF-kappa B; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA; Trinitrobenzenesulfonic Acid; U937 Cells | 2012 |
Osteopontin biomarker in inflammatory bowel disease, animal models and target for drug discovery.
Topics: Animals; Colitis; Male; Osteopontin; Trinitrobenzenesulfonic Acid | 2012 |
Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice.
Topics: Administration, Oral; Administration, Rectal; Administration, Topical; Animals; Anti-Inflammatory Agents; Cannabidiol; Colitis; Disease Models, Animal; Injections, Intraperitoneal; Male; Mice; Peroxidase; Trinitrobenzenesulfonic Acid | 2012 |
Effect of COX-2 inhibitor lumiracoxib and the TNF-α antagonist etanercept on TNBS-induced colitis in Wistar rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diclofenac; Disease Models, Animal; Down-Regulation; Drug Therapy, Combination; Etanercept; Humans; Immunoglobulin G; Inflammatory Bowel Diseases; Male; Random Allocation; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Intraperitoneal but not intravenous cryopreserved mesenchymal stromal cells home to the inflamed colon and ameliorate experimental colitis.
Topics: Animals; Apoptosis; Bone Marrow Cells; Cell Lineage; Cell Movement; Colitis; Collagen; Colon; Colonoscopy; Cryopreservation; Cytokines; Disease Models, Animal; Inflammation; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Mucosa; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Rats; Rats, Wistar; Subcutaneous Fat; Trinitrobenzenesulfonic Acid; Wound Healing | 2012 |
Nanoparticle-based clodronate delivery mitigates murine experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Line; Cell Survival; Clodronic Acid; Colitis; Disease Models, Animal; Humans; Mice; Nanoparticles; Oxazolone; Polymers; Trinitrobenzenesulfonic Acid | 2012 |
Hydrogen sulfide-induced colonic mucosal cytoprotection involves T-type calcium channel-dependent neuronal excitation in rats.
Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Capsaicin; Colitis; Colon; Cystathionine beta-Synthase; Cystathionine gamma-Lyase; Cytoprotection; Extracellular Signal-Regulated MAP Kinases; Ganglia, Spinal; Hydrogen Sulfide; Intestinal Mucosa; Male; Mucous Membrane; Neurons; Nociceptors; Pain; Phosphorylation; Posterior Horn Cells; Rats; Rats, Wistar; Sensory Receptor Cells; Spine; Trinitrobenzenesulfonic Acid | 2012 |
Dietary intervention with green dwarf banana flour (Musa sp AAA) prevents intestinal inflammation in a trinitrobenzenesulfonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dietary Supplements; Disease Models, Animal; Drug Synergism; Flour; Fruit; Glutathione; Inflammation; Lipid Peroxidation; Male; Musa; Oxidation-Reduction; Peroxidase; Phytotherapy; Plant Preparations; Prebiotics; Prednisolone; Rats, Wistar; Starch; Trinitrobenzenesulfonic Acid | 2012 |
Nitric oxide modifies chromatin to suppress ICAM-1 expression during colonic inflammation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Colitis; Down-Regulation; Histone Deacetylases; Histones; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lysine; Male; NF-kappa B; Nitric Oxide; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transfection; Translocation, Genetic; Trinitrobenzenesulfonic Acid | 2012 |
Metabolite profiling of plasma and urine from rats with TNBS-induced acute colitis using UPLC-ESI-QTOF-MS-based metabonomics--a pilot study.
Topics: Acute Disease; Animals; Biomarkers; Chromatography, Liquid; Colitis; Disease Models, Animal; Male; Metabolomics; Pilot Projects; Rats; Rats, Sprague-Dawley; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trinitrobenzenesulfonic Acid | 2012 |
Inhibitory effect of β-sitosterol on TNBS-induced colitis in mice.
Topics: Animals; Colitis; Cyclooxygenase 2; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred C57BL; NF-kappa B; Peroxidase; Sitosterols; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Alkaline Phosphatase; Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Diarrhea; Dietary Fiber; Dietary Supplements; Disease Models, Animal; Flour; Glutathione; Inflammation; Intestinal Mucosa; Male; Organ Size; Peroxidase; Phytotherapy; Plant Preparations; Prednisolone; Rats; Rats, Wistar; Rhizome; Trinitrobenzenesulfonic Acid; Typhaceae | 2012 |
Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats.
Topics: Alkaline Phosphatase; Animals; Bacterial Translocation; Colitis; Dextran Sulfate; Disease Models, Animal; DNA, Bacterial; Feces; Female; Gene Expression Regulation, Enzymologic; Liver; Mice; Mice, Inbred C57BL; Mice, SCID; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2012 |
Dietary phosphatidylcholine supplementation attenuates inflammatory mucosal damage in a rat model of experimental colitis.
Topics: Animals; Colitis; Colon; Dietary Supplements; Hemodynamics; Interleukin-6; Intestinal Mucosa; Male; Microcirculation; Nitric Oxide; Peroxidase; Phosphatidylcholines; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Xanthine Dehydrogenase | 2012 |
Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis.
Topics: Animals; Apoptosis; Colitis; Cysteine Endopeptidases; Cytokines; Dextran Sulfate; Intestinal Mucosa; Intracellular Signaling Peptides and Proteins; Mice; Mice, Transgenic; NF-kappa B; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor alpha-Induced Protein 3 | 2012 |
Infliximab modifies mesenteric adipose tissue alterations and intestinal inflammation in rats with TNBS-induced colitis.
Topics: Adipose Tissue; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Monoclonal; Cell Survival; Colitis; Disease Models, Animal; Gene Expression; Humans; Infliximab; Interleukin-10; JNK Mitogen-Activated Protein Kinases; Male; Mesentery; Nitric Oxide Synthase Type II; Peroxidase; Phosphorylation; PPAR gamma; Rats; Rats, Wistar; Resistin; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; U937 Cells | 2012 |
Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats.
Topics: Animals; Colitis; Disease Models, Animal; Ethanol; Irritable Bowel Syndrome; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2012 |
Oral treatment with Hev b 13 ameliorates experimental colitis in mice.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antigens, Plant; Colitis; Colon; Crohn Disease; Diarrhea; Female; Humans; Interleukin-10; Mice; Mice, Inbred BALB C; Plant Proteins; Rectal Prolapse; Trinitrobenzenesulfonic Acid; Weight Loss | 2012 |
Dietary supplementation of an ellagic acid-enriched pomegranate extract attenuates chronic colonic inflammation in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Crohn Disease; Cyclooxygenase 2; Dietary Supplements; Disease Models, Animal; Ellagic Acid; I-kappa B Proteins; Interferon-alpha; Intestinal Mucosa; Lythraceae; Male; MAP Kinase Kinase 4; MAP Kinase Signaling System; NF-kappa B; NF-KappaB Inhibitor alpha; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; Plant Extracts; Polyphenols; Rats; Rats, Wistar; Signal Transduction; Trinitrobenzenesulfonic Acid | 2012 |
Vidofludimus inhibits colonic interleukin-17 and improves hapten-induced colitis in rats by a unique dual mode of action.
Topics: Animals; Biphenyl Compounds; CD3 Complex; Cell Proliferation; Colitis; Colon; Dicarboxylic Acids; Female; Haptens; Inflammation; Interleukin-17; Interleukin-1beta; Interleukin-23; NF-kappa B; Rats; Rats, Wistar; STAT3 Transcription Factor; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Uridine | 2012 |
Macromolecular prodrug of 4-aminosalicylic acid for targeted delivery to inflamed colon.
Topics: 1-Octanol; Aminosalicylic Acid; Animals; Anti-Inflammatory Agents; beta-Cyclodextrins; Colitis; Drug Stability; Feces; Liver; Pancreas; Prodrugs; Rats; Rats, Wistar; Solubility; Stomach; Trinitrobenzenesulfonic Acid; Water | 2013 |
Proteome profiling of spinal cord and dorsal root ganglia in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Colon; Ganglia, Spinal; Male; Peroxidase; Proteins; Proteome; Rats; Rats, Sprague-Dawley; Spinal Cord; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Spores from two distinct colony types of the strain Bacillus subtilis PB6 substantiate anti-inflammatory probiotic effects in mice.
Topics: Animals; Anti-Inflammatory Agents; Bacillus subtilis; Body Weight; Cell Line; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Interferon-gamma; Interleukin-10; Interleukin-12; Leukocytes, Mononuclear; Mice; Neutrophils; Probiotics; Serum Amyloid A Protein; Spores, Bacterial; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
The protective and healing effects of Si Shen Wan in trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Colitis; Drugs, Chinese Herbal; Female; Glutathione Peroxidase; Interleukin-10; Interleukin-4; Intestinal Mucosa; Male; Malondialdehyde; Peroxidase; Phytotherapy; Protective Agents; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2012 |
Reappraisal of total body irradiation followed by bone marrow transplantation as a therapy for inflammatory bowel disease.
Topics: Animals; Bone Marrow Transplantation; Colitis; Combined Modality Therapy; Cytokines; Disease Models, Animal; Female; Humans; Immunosuppression Therapy; Inflammation Mediators; Inflammatory Bowel Diseases; Male; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Weight Gain; Whole-Body Irradiation | 2013 |
Dynamic progress of 2,4,6-trinitrobenzene sulfonic acid induced chronic colitis and fibrosis in rat model.
Topics: Analysis of Variance; Animals; Chronic Disease; Colitis; Collagen Type I; Collagen Type III; Colon; Connective Tissue Growth Factor; Cytokines; Female; Fibrosis; Gene Expression; Interleukin-13; Interleukin-17; Interleukin-2; Interleukin-4; Rats; Rats, Sprague-Dawley; RNA, Messenger; Smad3 Protein; Time Factors; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Tissue inhibitor of metalloproteinase-3 regulates inflammation in human and mouse intestine.
Topics: Adult; Aged; Amyloid Precursor Protein Secretases; Animals; Cells, Cultured; Colitis; Colitis, Ulcerative; Crohn Disease; Cytokines; Down-Regulation; Gene Knockdown Techniques; Gene Knockout Techniques; Humans; Intestinal Mucosa; Leukocytes, Mononuclear; Mice; Mice, Knockout; Mice, Transgenic; Middle Aged; Oligonucleotides, Antisense; RNA, Messenger; Smad7 Protein; Tissue Inhibitor of Metalloproteinase-3; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2012 |
ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation.
Topics: Angiotensin-Converting Enzyme 2; Animals; Biocatalysis; Colitis; Dextran Sulfate; Diarrhea; Dietary Proteins; Female; Gene Deletion; Genetic Predisposition to Disease; Germ-Free Life; Homeostasis; Immunity, Innate; Intestines; Male; Malnutrition; Metagenome; Mice; Models, Biological; Niacinamide; Peptidyl-Dipeptidase A; Renin-Angiotensin System; TOR Serine-Threonine Kinases; Trinitrobenzenesulfonic Acid; Tryptophan | 2012 |
Adjunct therapy of n-3 fatty acids to 5-ASA ameliorates inflammatory score and decreases NF-κB in rats with TNBS-induced colitis.
Topics: Animals; Colitis; Fatty Acids, Omega-3; Inflammation; Male; Mesalamine; NF-kappa B; PPAR gamma; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2013 |
MC-12, an annexin A1-based peptide, is effective in the treatment of experimental colitis.
Topics: Animals; Annexin A1; Cell Line; Colitis; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Female; Group IV Phospholipases A2; Humans; Intestinal Mucosa; Mice; NF-kappa B; Oligopeptides; Peroxidase; Trinitrobenzenesulfonic Acid | 2012 |
Ginsenoside Re ameliorates inflammation by inhibiting the binding of lipopolysaccharide to TLR4 on macrophages.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Drug Evaluation, Preclinical; Ginsenosides; Inflammation; Interleukin-1beta; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred ICR; Myeloid Differentiation Factor 88; NF-kappa B; Nitric Oxide Synthase Type II; Peptidoglycan; Phosphorylation; RNA, Small Interfering; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Altered colorectal afferent function associated with TNBS-induced visceral hypersensitivity in mice.
Topics: Administration, Rectal; Animals; Colitis; Colon; Disease Models, Animal; Hypersensitivity; Immunoenzyme Techniques; Immunohistochemistry; Inflammation; Mechanoreceptors; Mechanotransduction, Cellular; Mice; Mice, Inbred C57BL; Physical Stimulation; Rectum; Saline Solution, Hypertonic; Time Factors; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2012 |
Chios mastic fractions in experimental colitis: implication of the nuclear factor κB pathway in cultured HT29 cells.
Topics: Adult; Animals; Anti-Inflammatory Agents; Colitis; Colon; Down-Regulation; Epithelial Cells; Female; HT29 Cells; Humans; Intercellular Adhesion Molecule-1; Interleukin-6; Interleukin-8; Leukocytes, Mononuclear; Male; Mastic Resin; Middle Aged; NF-kappa B; Pistacia; Plant Extracts; Rats; Rats, Wistar; Resins, Plant; Signal Transduction; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Young Adult | 2012 |
Up-regulation of brain-derived neurotrophic factor is regulated by extracellular signal-regulated protein kinase 5 and by nerve growth factor retrograde signaling in colonic afferent neurons in colitis.
Topics: Amidines; Animals; Brain-Derived Neurotrophic Factor; Colitis; Colon; Disease Models, Animal; Diterpenes; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Ganglia, Spinal; Male; Mitogen-Activated Protein Kinase 7; Nerve Growth Factor; Neurons, Afferent; Rats; Rats, Sprague-Dawley; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2012 |
[Comparative study of novel therapeutic possibilities in animal experimental model of inflammatory bowel disease].
Topics: Administration, Oral; Animals; Biomarkers; Colitis; Disease Models, Animal; Excitatory Amino Acid Antagonists; Inflammation; Inflammatory Bowel Diseases; Intestinal Mucosa; Kynurenic Acid; Microcirculation; Microscopy, Confocal; Peroxidase; Phosphatidylcholines; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Active hexose-correlated compound and Bifidobacterium longum BB536 exert symbiotic effects in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Blotting, Western; Colitis; Colon; Cyclooxygenase 2; Disease Models, Animal; Drug Synergism; Female; Gene Expression; Interferon-gamma; Interleukin-1beta; Interleukin-2; Nitric Oxide Synthase Type II; Organ Size; Polysaccharides; Prebiotics; Probiotics; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Gain | 2013 |
Enhanced excitability of guinea pig inferior mesenteric ganglion neurons during and following recovery from chemical colitis.
Topics: Acetic Acid; Action Potentials; Animals; Anthracenes; Colitis; Disease Models, Animal; Electrophysiology; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Guinea Pigs; Indicators and Reagents; Intestines; Myenteric Plexus; Reaction Time; Riluzole; Trinitrobenzenesulfonic Acid | 2012 |
Altered response to hydrogen sulphide during experimental colitis in rats.
Topics: Aminopyridines; Analgesics; Animals; Colitis; Diet; Female; Hydrogen Sulfide; Inflammation; Intestines; Male; Rats; Rats, Wistar; Sulfur; Trinitrobenzenesulfonic Acid | 2013 |
Adeno-associated virus mediated delivery of Tregitope 167 ameliorates experimental colitis.
Topics: Animals; Cell Count; Colitis; Colon; Dependovirus; Disease Models, Animal; DNA, Complementary; Epitopes, T-Lymphocyte; Forkhead Transcription Factors; Genetic Therapy; Intestinal Mucosa; Male; Membrane Proteins; Mice; Mice, Inbred BALB C; T-Lymphocytes, Regulatory; Thymus Gland; Trinitrobenzenesulfonic Acid | 2012 |
Colitis is associated with a loss of intestinofugal neurons.
Topics: Amidines; Animals; Colitis; Female; Ganglia, Sympathetic; Guinea Pigs; Intestines; Male; Myenteric Plexus; Neurons; Trinitrobenzenesulfonic Acid | 2012 |
4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis.
Topics: Adamantane; Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding, Competitive; Blood Proteins; CHO Cells; Colitis; Cricetinae; Cricetulus; Humans; Intestinal Absorption; Ligands; Mice; Microsomes, Liver; Protein Binding; Pyridines; Radioligand Assay; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Trinitrobenzenesulfonic Acid | 2012 |
Ginger extract and zingerone ameliorated trinitrobenzene sulphonic acid-induced colitis in mice via modulation of nuclear factor-κB activity and interleukin-1β signalling pathway.
Topics: Animals; Colitis; Female; Guaiacol; Humans; Interleukin-1beta; Mice; Mice, Inbred BALB C; NF-kappa B; Plant Extracts; Signal Transduction; Trinitrobenzenesulfonic Acid; Zingiber officinale | 2013 |
Cytokine expression and the role of Th17 cells in a mouse model of colitis.
Topics: Animals; Antibodies; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Interferon-gamma; Interleukin-17; Interleukin-6; Leukocytes, Mononuclear; Lymph Nodes; Mice; Mice, Inbred BALB C; RNA, Messenger; Spleen; Th17 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
IL-17/IFN-γ interactions regulate intestinal inflammation in TNBS-induced acute colitis.
Topics: Animals; Antibodies, Monoclonal; Colitis; Cytokines; Inflammation; Interferon-gamma; Interleukin-17; Intestines; Mice; Mice, Inbred BALB C; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Signal Transduction; Th1 Cells; Th17 Cells; Trinitrobenzenesulfonic Acid | 2012 |
Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models: influence of genetic and environmental factors.
Topics: Animals; Anti-Bacterial Agents; Carrier Proteins; Colitis; Dendritic Cells; Disease Models, Animal; Environment; Epithelial Cells; Genetic Predisposition to Disease; Humans; Immune Tolerance; Inflammasomes; Inflammatory Bowel Diseases; Intestines; Metagenome; Mice; Mucous Membrane; NLR Family, Pyrin Domain-Containing 3 Protein; Phenotype; Protective Agents; Trinitrobenzenesulfonic Acid | 2012 |
Role of TRPV1 and TRPA1 in visceral hypersensitivity to colorectal distension during experimental colitis in rats.
Topics: Acetanilides; Animals; Colitis; Colon; Drug Synergism; Female; Purines; Pyrazines; Pyridines; Rats; Rats, Wistar; Rectum; Reflex; Trinitrobenzenesulfonic Acid; TRPA1 Cation Channel; TRPC Cation Channels; TRPV Cation Channels | 2013 |
Cytokine expression and the role of Thl7 cells in mice colitis.
Topics: Animals; Antibodies; Blotting, Western; Cells, Cultured; Colitis; Colon; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Inflammation Mediators; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Spleen; Th1 Cells; Th17 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2012 |
Developmental origins of functional dyspepsia-like gastric hypersensitivity in rats.
Topics: Abdominal Pain; Animals; Colitis; Colon; Disease Models, Animal; Dyspepsia; Glucocorticoids; Hypersensitivity; Male; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stomach Diseases; Trinitrobenzenesulfonic Acid | 2013 |
Differential effects of intravesical resiniferatoxin on excitability of bladder spinal neurons upon colon-bladder cross-sensitization.
Topics: Animals; Blotting, Western; Colitis; Colon; Data Interpretation, Statistical; Diterpenes; Lumbosacral Plexus; Male; Neurons; Neurons, Afferent; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Urinary Bladder; Urinary Bladder Diseases | 2013 |
The possible mechanisms of Picrasma quassiodes (D. Don) Benn. in the treatment of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in mice.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cyclooxygenase 2; Interleukin-8; Male; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Peroxidase; Phytotherapy; Picrasma; Plant Extracts; Plant Stems; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Treatment of experimental murine colitis with CD40 antisense oligonucleotides delivered in amphoteric liposomes.
Topics: Animals; B-Lymphocytes; CD40 Antigens; Chemokine CXCL10; Colitis; Female; Interleukin-6; Liposomes; Macrophages; Male; Mice; Mice, Inbred BALB C; Oligonucleotides, Antisense; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2013 |
Evidence for the role of mast cells in colon-bladder cross organ sensitization.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Female; Ketotifen; Mast Cells; Membrane Transport Modulators; Mice; Mice, Knockout; Muscle Contraction; Neurons, Afferent; Oligopeptides; p-Methoxy-N-methylphenethylamine; Permeability; Proto-Oncogene Proteins c-kit; Rats; Rats, Sprague-Dawley; Receptor, PAR-2; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urination Disorders | 2013 |
Oligosaccharides from agar inhibit murine intestinal inflammation through the induction of heme oxygenase-1 expression.
Topics: Animals; Anti-Inflammatory Agents; Blotting, Western; Cell Line; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Heme Oxygenase-1; Inflammation; Macrophages; Male; Mice; Mice, Inbred C57BL; Oligosaccharides; Real-Time Polymerase Chain Reaction; Sepharose; Time Factors; Trinitrobenzenesulfonic Acid | 2013 |
Effectiveness of Saccharomyces boulardii in a rat model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Disease Models, Animal; Female; Gastrointestinal Agents; Inflammation Mediators; Methylprednisolone; Nitric Oxide; Probiotics; Rats; Rats, Wistar; Saccharomyces; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2012 |
Glutamine treatment attenuates endoplasmic reticulum stress and apoptosis in TNBS-induced colitis.
Topics: Animals; Apoptosis; Brefeldin A; Caco-2 Cells; Caspases; Cell Line, Tumor; Cell Survival; Colitis; Endoplasmic Reticulum; Glutamine; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Male; Oxidative Stress; Phosphorylation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Transcription Factor CHOP; Trinitrobenzenesulfonic Acid; Tunicamycin | 2012 |
Temporal colonic gene expression profiling in the recurrent colitis model identifies early and chronic inflammatory processes.
Topics: Administration, Rectal; Animals; Anti-Inflammatory Agents; Budesonide; Chronic Disease; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Gene Expression Profiling; Gene Expression Regulation; Immunomodulation; Inflammation; Mice; Mice, Inbred BALB C; Oligonucleotide Array Sequence Analysis; Signal Transduction; Th1-Th2 Balance; Time Factors; Transcriptome; Trinitrobenzenesulfonic Acid | 2012 |
An IL-17 peptide-based and virus-like particle vaccine enhances the bioactivity of IL-17 in vitro and in vivo.
Topics: Animals; Colitis; Colon; Female; Hepatitis B Core Antigens; Humans; Immunoglobulin G; Immunotherapy; Interleukin-17; Interleukin-6; Macrophages; Mice; Mice, Inbred BALB C; Models, Animal; NIH 3T3 Cells; Peptide Fragments; Protein Engineering; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vaccines, Virus-Like Particle | 2012 |
Sesame oil accelerates healing of 2,4,6-trinitrobenzenesulfonic acid-induced acute colitis by attenuating inflammation and fibrosis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Fibrosis; Inflammation; Male; Organ Size; Rats; Rats, Wistar; Sesame Oil; Trinitrobenzenesulfonic Acid | 2013 |
Curcumin improves TNBS-induced colitis in rats by inhibiting IL-27 expression via the TLR4/NF-κB signaling pathway.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Curcumin; Disease Models, Animal; Gastrointestinal Agents; Inflammation; Interleukins; Intestinal Mucosa; Male; NF-kappa B; Peroxidase; Random Allocation; Rats; Signal Transduction; Sulfasalazine; Toll-Like Receptor 4; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2013 |
Exploiting the synergistic effect of chitosan-EDTA conjugate with MSA for the early recovery from colitis.
Topics: Adhesiveness; Animals; Calorimetry, Differential Scanning; Chitosan; Colitis; Colon; Drug Synergism; Edetic Acid; Hydrogen-Ion Concentration; Mesalamine; Microscopy, Electron, Scanning; Powders; Rats; Rats, Sprague-Dawley; Spectroscopy, Fourier Transform Infrared; Tablets; Trinitrobenzenesulfonic Acid | 2013 |
Transplantation of granulocytic myeloid-derived suppressor cells (G-MDSCs) could reduce colitis in experimental murine models.
Topics: Animals; Body Weight; Colitis; Cytokines; Disease Models, Animal; Female; Graft Survival; Granulocytes; Inflammation Mediators; Male; Mice; Mice, Inbred BALB C; Myeloid Cells; Peroxidase; Trinitrobenzenesulfonic Acid | 2013 |
Loss of phosphoinositide 3-kinase P110γ is protective in the acute phase but detrimental in the resolution phase of hapten-induced colitis.
Topics: Acute Disease; Animals; Bacterial Translocation; Biomarkers; Chronic Disease; Class Ib Phosphatidylinositol 3-Kinase; Colitis; Cytokines; Fluorescent Antibody Technique; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophil Infiltration; Peroxidase; Phagocytosis; Real-Time Polymerase Chain Reaction; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Weight Loss | 2013 |
Disturbance of hepatic and intestinal UDP-glucuronosyltransferase in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Constitutive Androstane Receptor; Glucuronosyltransferase; Intestine, Small; Liver; Male; Rats; Rats, Wistar; Receptors, Aryl Hydrocarbon; Receptors, Cytoplasmic and Nuclear; Transcription Factors; Trinitrobenzenesulfonic Acid | 2013 |
Anti-inflammatory Lactobacillus rhamnosus CNCM I-3690 strain protects against oxidative stress and increases lifespan in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Colitis; Female; Forkhead Transcription Factors; Gene Expression Profiling; HT29 Cells; Humans; Inflammation; Insulin; Lactobacillus; Longevity; Mice; Oxidative Stress; Probiotics; Reactive Oxygen Species; Receptor, Insulin; Signal Transduction; Species Specificity; Transcription Factors; Trinitrobenzenesulfonic Acid | 2012 |
Host immune response determines visceral hyperalgesia in a rat model of post-inflammatory irritable bowel syndrome.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Hyperalgesia; Interleukin-2; Interleukin-6; Irritable Bowel Syndrome; Male; Rats; Rats, Inbred F344; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid | 2013 |
Early detection of renal injury using urinary vanin-1 in rats with experimental colitis.
Topics: Acetylglucosaminidase; Amidohydrolases; Animals; Biomarkers; Cell Adhesion Molecules; Chemokine CCL2; Colitis; Colon; Creatinine; Disease Models, Animal; Early Diagnosis; GPI-Linked Proteins; Kidney; Kidney Diseases; Kidney Function Tests; Male; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2014 |
Anti-inflammatory intestinal activity of Arctium lappa L. (Asteraceae) in TNBS colitis model.
Topics: Animals; Anti-Inflammatory Agents; Arctium; Colitis; Cyclooxygenase 2; Disease Models, Animal; Male; Peroxidase; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Echinocystic acid, a metabolite of lancemaside A, inhibits TNBS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Codonopsis; Colitis; Colon; Cytokines; Humans; Inflammation Mediators; Lipopolysaccharides; Macrophages, Peritoneal; Male; Medicine, Chinese Traditional; Mice; Mice, Inbred ICR; NF-kappa B; Oleanolic Acid; Protein Binding; Rhizome; Saponins; Signal Transduction; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2013 |
Protective and worsening peripheral nociceptin/orphanin FQ receptor-mediated effect in a rat model of experimental colitis.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Intestinal Mucosa; Male; Nociceptin; Nociceptin Receptor; Opioid Peptides; Protein Binding; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid; Trinitrobenzenesulfonic Acid | 2013 |
The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
Topics: Animals; Cells, Cultured; Colitis; Gene Expression Regulation; Humans; Immunity, Innate; Inflammation; Interferon Regulatory Factor-7; Intestines; Male; Mice; Mice, Knockout; Monocytes; Myeloid Differentiation Factor 88; Oligodeoxyribonucleotides; Promoter Regions, Genetic; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Toll-Like Receptor 9; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2013 |
Arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the PI3K/AKT pathway and polarizing M1 macrophages to M2-like macrophages.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Cytokines; Furans; Lignans; Lipopolysaccharides; Macrophages, Peritoneal; Male; Mice; Mice, Inbred C57BL; Peroxidase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Trinitrobenzenesulfonic Acid | 2013 |
β-Arrestin-1 deficiency protects mice from experimental colitis.
Topics: Animals; Arrestins; beta-Arrestin 1; beta-Arrestins; Colitis; Colon; Dextran Sulfate; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Inflammation; Interleukin-10; Interleukin-6; Mice; Mice, Knockout; NF-kappa B; Signal Transduction; Trinitrobenzenesulfonic Acid; Weight Loss | 2013 |
Intestinal anti-inflammatory activity of hydroalcoholic extracts of Phlomis purpurea L. and Phlomis lychnitis L. in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Glutathione; Intestinal Mucosa; Mucins; Necrosis; Peroxidase; Phlomis; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2013 |
Disturbances of colonic ion secretion in inflammation: role of the enteric nervous system and cAMP.
Topics: 1-Methyl-3-isobutylxanthine; Anesthetics, Local; Animals; Biological Transport; Carbachol; Cholinergic Agonists; Colitis; Colon; Cyclic AMP; Cystic Fibrosis Transmembrane Conductance Regulator; Enteric Nervous System; Female; Gene Expression; Intestinal Mucosa; Ions; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2002 |
Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses.
Topics: Animals; Chromosome Mapping; Colitis; Female; Genetic Predisposition to Disease; Genotype; Inflammatory Bowel Diseases; Interleukin-12; Male; Mice; Mice, Inbred C57BL; Sex Factors; Trinitrobenzenesulfonic Acid | 2002 |
Endothelin in human inflammatory bowel disease: comparison to rat trinitrobenzenesulphonic acid-induced colitis.
Topics: Animals; Colitis; Dinoprostone; Endothelin-1; Endothelin-2; Endothelins; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; L-Lactate Dehydrogenase; Male; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2002 |
Could honey have a place in colitis therapy? Effects of honey, prednisolone, and disulfiram on inflammation, nitric oxide, and free radical formation.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Disease Models, Animal; Disulfiram; Enzyme Inhibitors; Honey; Male; Nitric Oxide; Peroxidase; Prednisolone; Rats; Rats, Wistar; Reactive Oxygen Species; Trinitrobenzenesulfonic Acid | 2002 |
Temporal changes in colonic vascular architecture and inflammatory mediator levels in animal models of colitis.
Topics: Animals; Blood Vessels; Colitis; Colon; Dinoprostone; Inflammation Mediators; Male; Rabbits; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Thromboxane B2; Time Factors; Trinitrobenzenesulfonic Acid | 2002 |
Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Colitis; Colon; Dextran Sulfate; Leukotriene B4; Leukotriene C4; Mice; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2002 |
Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension.
Topics: Animals; Central Nervous System Depressants; Colitis; Colon; Electromyography; Ethanol; Male; Nociceptors; Pressure; Rats; Rats, Inbred Lew; Rectum; Trinitrobenzenesulfonic Acid | 2002 |
Melatonin reduces colon immunological injury in rats by regulating activity of macrophages.
Topics: Animals; Colitis; Colon; Ethanol; Interleukin-1; Intestinal Mucosa; Macrophages; Male; Melatonin; Nitric Oxide; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2002 |
Galacto-oligosaccharides stimulate the growth of bifidobacteria but fail to attenuate inflammation in experimental colitis in rats.
Topics: Animals; Bifidobacterium; Body Weight; Colitis; Colon; Colony Count, Microbial; Dexamethasone; Galactans; Glucocorticoids; Intestinal Mucosa; Male; Models, Animal; Oligosaccharides; Rats; Trinitrobenzenesulfonic Acid | 2002 |
Lisofylline and lysophospholipids ameliorate experimental colitis in rats.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Ethanol; Lysophospholipids; Male; Pentoxifylline; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2002 |
NK 1.1+ T cell: a two-faced lymphocyte in immune modulation of the IL-4/IFN-gamma paradigm.
Topics: Administration, Oral; Animals; Antibody Formation; Biomarkers; Colitis; Cytotoxicity, Immunologic; Immune Tolerance; Interferon-gamma; Interleukin-4; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Models, Animal; Trinitrobenzenesulfonic Acid | 2002 |
Dietary fiber down-regulates colonic tumor necrosis factor alpha and nitric oxide production in trinitrobenzenesulfonic acid-induced colitic rats.
Topics: Adenocarcinoma; Animals; Butyric Acid; Colitis; Colon; Colonic Neoplasms; Dietary Fiber; Female; Glutathione; Humans; Interleukin-8; Intestinal Mucosa; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Propionates; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2002 |
NCX-1015, a nitric-oxide derivative of prednisolone, enhances regulatory T cells in the lamina propria and protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Colitis; Drug Evaluation, Preclinical; Endothelium, Vascular; Interferon-gamma; Interleukin-10; Intestinal Mucosa; Lymphokines; Male; Mesentery; Mice; Mice, Inbred BALB C; Models, Animal; Neutrophils; NF-kappa B; Peroxidase; Prednisolone; T-Lymphocyte Subsets; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2002 |
Exposure to schistosome eggs protects mice from TNBS-induced colitis.
Topics: Animals; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Hypoxanthine Phosphoribosyltransferase; Intestinal Mucosa; Lymph Nodes; Mesentery; Mice; Mice, Inbred BALB C; Ovum; Reverse Transcriptase Polymerase Chain Reaction; Schistosoma mansoni; Spleen; Trinitrobenzenesulfonic Acid | 2003 |
Short-chain fatty acid enemas fail to decrease colonic hypersensitivity and inflammation in TNBS-induced colonic inflammation in rats.
Topics: Acetates; Animals; Behavior, Animal; Butyrates; Colitis; Colonic Diseases, Functional; Enema; Fatty Acids, Volatile; Male; Pressure; Propionates; Rats; Rats, Sprague-Dawley; Sodium Chloride; Trinitrobenzenesulfonic Acid | 2002 |
Prevention of colitis by interleukin 10-transduced T lymphocytes in the SCID mice transfer model.
Topics: Animals; CD4-Positive T-Lymphocytes; Cell Survival; Colitis; Cytokines; Green Fluorescent Proteins; Indicators and Reagents; Inflammation Mediators; Interleukin-10; Leukocyte Common Antigens; Luminescent Proteins; Mice; Mice, Inbred BALB C; Mice, SCID; Spleen; Transduction, Genetic; Trinitrobenzenesulfonic Acid | 2002 |
Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Body Weight; Colitis; Colon; Curcumin; Cytokines; Dose-Response Relationship, Drug; Gene Expression; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; NF-kappa B; Survival Rate; Trinitrobenzenesulfonic Acid | 2002 |
IL-10 gene therapy prevents TNBS-induced colitis.
Topics: Adenoviridae; Animals; Colitis; Colon; Feces; Genetic Therapy; Genetic Vectors; Interferon-gamma; Interleukin-1; Interleukin-10; Interleukin-6; Mice; Mice, Inbred BALB C; Serum Amyloid A Protein; Transduction, Genetic; Trinitrobenzenesulfonic Acid | 2002 |
Importance of innate immunity and collagen binding integrin alpha1beta1 in TNBS-induced colitis.
Topics: Animals; Antibodies, Monoclonal; Colitis; Collagen; Extracellular Matrix; Female; Immunity, Innate; Integrin alpha1beta1; Mice; Mice, Inbred BALB C; Mice, SCID; Monocytes; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2002 |
Immunomodulation of experimental colitis via caloric restriction: role of Nk1.1+ T cells.
Topics: Animals; Caloric Restriction; CD4-CD8 Ratio; Cell Division; Colitis; Cytokines; Down-Regulation; Flow Cytometry; Intestinal Mucosa; Killer Cells, Natural; Liver; Male; Mice; Mice, Inbred C57BL; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured | 2002 |
Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat.
Topics: Animals; Capsaicin; Colitis; Female; Ganglia, Spinal; Gene Expression; Genes, fos; Genes, Immediate-Early; Genes, jun; Irritants; Neurons; Peptides, Cyclic; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-2; Spinal Cord; Trinitrobenzenesulfonic Acid | 2003 |
The prebiotic characteristics of fructooligosaccharides are necessary for reduction of TNBS-induced colitis in rats.
Topics: Analysis of Variance; Animals; Butyrates; Colitis; Lactates; Male; Oligosaccharides; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2003 |
Nitric oxide synthase immunoreactivity of interstitial cells of Cajal in experimental colitis.
Topics: Animals; Colitis; Colon; Immunohistochemistry; Male; Nerve Fibers; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Rats; Trinitrobenzenesulfonic Acid | 2002 |
Effects of dosmalfate, a new cytoprotective agent, on acute and chronic trinitrobenzene sulphonic acid-induced colitis in rats.
Topics: Acute-Phase Reaction; Animals; Colitis; Colon; Diosmin; ErbB Receptors; Immunohistochemistry; Inflammation; Instillation, Drug; Intestinal Mucosa; Male; Peroxidase; Protective Agents; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Enhanced excitability of myenteric AH neurones in the inflamed guinea-pig distal colon.
Topics: Action Potentials; Animals; Calcium Channels; Cations; Colitis; Electric Conductivity; Electrophysiology; Excitatory Postsynaptic Potentials; Guinea Pigs; Ion Channels; Myenteric Plexus; Neurons; Neurons, Afferent; Reaction Time; Synapses; Trinitrobenzenesulfonic Acid | 2003 |
Inhibition of intestinal bacterial translocation with rifaximin modulates lamina propria monocytic cells reactivity and protects against inflammation in a rodent model of colitis.
Topics: Acute Disease; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Bacterial Translocation; Colitis; Colon; Cytokines; Dose-Response Relationship, Drug; Interferon-gamma; Intestinal Mucosa; Leukocytes, Mononuclear; Lymph Nodes; Mesentery; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Prednisolone; Rifamycins; Rifaximin; Trinitrobenzenesulfonic Acid | 2002 |
Compromised neuroimmune status in rats with experimental colitis.
Topics: Animals; Body Temperature; Circadian Rhythm; Colitis; Disease Models, Animal; Escherichia coli; Fever; Interleukin-6; Lipopolysaccharides; Male; Neuroimmunomodulation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Mechanisms involved in the loss of excitatory post-stimulus responses by inflammation.
Topics: Adenosine Triphosphate; Animals; Colitis; Cyclooxygenase Inhibitors; Electric Stimulation; Female; In Vitro Techniques; Indomethacin; Male; Methiothepin; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Purinergic P2 Receptor Antagonists; Quinuclidines; Rabbits; Serotonin Antagonists; Substance P; Suramin; Trinitrobenzenesulfonic Acid | 2003 |
Serotonin availability is increased in mucosa of guinea pigs with TNBS-induced colitis.
Topics: Animals; Carrier Proteins; Colitis; Female; Gastrointestinal Motility; Gene Expression; Guinea Pigs; Intestinal Mucosa; Male; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Serotonin; Serotonin Plasma Membrane Transport Proteins; Trinitrobenzenesulfonic Acid | 2003 |
Therapeutic effects of vasoactive intestinal peptide in the trinitrobenzene sulfonic acid mice model of Crohn's disease.
Topics: Animals; Colitis; Crohn Disease; Cytokines; Disease Models, Animal; Down-Regulation; Gastrointestinal Agents; Male; Mice; Mice, Inbred BALB C; Receptors, Vasoactive Intestinal Peptide; Receptors, Vasoactive Intestinal Polypeptide, Type I; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide; Wasting Syndrome | 2003 |
Evidence for the critical role of interleukin-12 but not interferon-gamma in the pathogenesis of experimental colitis in mice.
Topics: Animals; Antibodies, Monoclonal; Colitis; Interferon gamma Receptor; Interferon-gamma; Interleukin-12; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interferon; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2003 |
Amelioration of TNBS-induced colon inflammation in rats by phospholipase A2 inhibitor.
Topics: Animals; Cellulase; Colitis; Colon; Drug Combinations; Enzyme Inhibitors; Glycoside Hydrolases; Intestinal Mucosa; Permeability; Peroxidase; Phosphatidylethanolamines; Phospholipases A; Phospholipases A2; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 2003 |
Anti-inflammatory properties of the mu opioid receptor support its use in the treatment of colon inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; CD4-Positive T-Lymphocytes; Colitis; Colon; Cytokines; Disease Models, Animal; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, SCID; Naloxone; Narcotic Antagonists; Oligopeptides; Peroxidase; Receptors, Opioid, mu; Trinitrobenzenesulfonic Acid | 2003 |
Galectin-1 suppresses experimental colitis in mice.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Disease Models, Animal; Galectin 1; Gene Expression; Interferon-gamma; Interleukin-1; Interleukin-12; Mice; Mice, Inbred BALB C; Recombinant Proteins; Spleen; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Role of NK1.1+ and AsGm-1+ cells in oral immunoregulation of experimental colitis.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Asialoglycoprotein Receptor; Biomarkers; Biopsy, Needle; Colitis; Cytokines; Cytotoxicity, Immunologic; Disease Models, Animal; Flow Cytometry; Immune Tolerance; Immunohistochemistry; Killer Cells, Natural; Lectins, C-Type; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily B; Probability; Proteins; Random Allocation; Reference Values; Sensitivity and Specificity; Th1 Cells; Trinitrobenzenesulfonic Acid | 2003 |
Curcumin, the major component of food flavour turmeric, reduces mucosal injury in trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Curcuma; Curcumin; Cytokines; Dose-Response Relationship, Drug; Female; Intestinal Mucosa; Malondialdehyde; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Phytotherapy; Plant Extracts; RNA, Messenger; Serine Endopeptidases; Superoxides; Trinitrobenzenesulfonic Acid | 2003 |
Thearubigin, the major polyphenol of black tea, ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Catechin; Colitis; Dose-Response Relationship, Drug; Female; Flavonoids; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Phenols; Polyphenols; Tea; Trinitrobenzenesulfonic Acid | 2003 |
Hyperbaric oxygen improves healing in experimental rat colitis.
Topics: Analysis of Variance; Animals; Colitis; Colon; Hyperbaric Oxygenation; Male; Oxidation-Reduction; Peroxidase; Proteins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2002 |
Effect of the antioxidant Mesna (2-mercaptoethane sulfonate) on experimental colitis.
Topics: Animals; Antioxidants; Colitis; Female; Mesna; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2003 |
Early expression of interferon gamma following oral antigen administration is associated with peripheral tolerance induction.
Topics: Administration, Oral; Animals; Antigens; Body Weight; Colitis; Gene Expression; Immune Tolerance; Interferon-gamma; Interleukin-10; Male; Mice; Mice, Inbred BALB C; Time Factors; Trinitrobenzenesulfonic Acid | 2003 |
Use of mouse models to evaluate the persistence, safety, and immune modulation capacities of lactic acid bacteria.
Topics: Administration, Oral; Administration, Rectal; Animals; Bacterial Translocation; Colitis; Colon; Cytokines; Disease Models, Animal; Drug Evaluation, Preclinical; Ileum; Immune System; Inflammatory Bowel Diseases; Intestinal Mucosa; Lactobacillus; Lymph Nodes; Mice; Probiotics; RNA, Messenger; Safety; Species Specificity; Spleen; Stomach; Trinitrobenzenesulfonic Acid | 2003 |
Bacterial load in animal models of acute and chronic 'reactivated' colitis.
Topics: Acute Disease; Animals; Bacteria; Chronic Disease; Colitis; Colony Count, Microbial; Dextran Sulfate; Indicators and Reagents; Male; Models, Animal; Peroxidase; Rats; Rats, Sprague-Dawley; Recurrence; Trinitrobenzenesulfonic Acid | 2003 |
Analysis of the T cell receptor V beta repertoire in 2,4,6-trinitrobenzenesulfonic acid induced colitis in mice.
Topics: Animals; Colitis; Female; Indicators and Reagents; Mice; Models, Animal; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2003 |
The suppressive effect of bifidobacteria on Bacteroides vulgatus, a putative pathogenic microbe in inflammatory bowel disease.
Topics: Administration, Rectal; Animals; Antibodies, Bacterial; Bacteroides; Bacteroides Infections; Bifidobacterium; Coculture Techniques; Colitis; Disease Models, Animal; Germ-Free Life; Haptens; Immunoglobulin G; Immunoglobulin kappa-Chains; Inflammatory Bowel Diseases; Mice; Mice, Inbred BALB C; Peanut Agglutinin; Peyer's Patches; Probiotics; Receptors, Mitogen; Species Specificity; Trinitrobenzenesulfonic Acid | 2003 |
[Investigation of the effect of Na-butyrate on TNBS induced rat colitis].
Topics: Administration, Rectal; Animals; Butyrates; Colitis; Female; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2003 |
Mucosal sulfhydryl compounds evaluation by in vivo electron spin resonance spectroscopy in mice with experimental colitis.
Topics: Animals; Colitis; Electron Spin Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Sulfhydryl Compounds; Trinitrobenzenesulfonic Acid | 2003 |
Allograft inflammatory factor-1 regulates trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Calcium-Binding Proteins; Colitis; Colon; Cytokines; Female; Gene Expression; Interleukin-1; Mice; Mice, Inbred BALB C; Mice, Transgenic; Microfilament Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Th1 Cells; Trinitrobenzenesulfonic Acid | 2003 |
Central effects of selective NK1 and NK3 tachykinin receptor agonists on two models of experimentally-induced colitis in rats.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Interleukin-1; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Tachykinin; Survival Rate; Time Factors; Trinitrobenzenesulfonic Acid | 2003 |
Dietary glycine prevents chemical-induced experimental colitis in the rat.
Topics: Animals; Cells, Cultured; Chemokine CXCL2; Chemokines; Chemokines, CXC; Colitis; Colon; Cytokines; Glycine; Intercellular Signaling Peptides and Proteins; Interleukin-1; Male; Monokines; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
CCR6 has a non-redundant role in the development of inflammatory bowel disease.
Topics: Animals; Chemokine CCL20; Chemokines, CC; Colitis; Cytokines; Dextran Sulfate; Disease Susceptibility; Inflammatory Bowel Diseases; Macrophage Inflammatory Proteins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Receptors, CCR6; Receptors, Chemokine; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2003 |
Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Cytokines; Dendritic Cells; Disease Models, Animal; Female; Interferon-gamma; Interleukin-4; Killer Cells, Natural; Mice; Mice, Inbred C57BL; Spleen; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2004 |
Effects of Rheum tanguticum polysaccharide on TNBS -induced colitis and CD4+T cells in rats.
Topics: Animals; Body Weight; CD4-Positive T-Lymphocytes; Colitis; Drugs, Chinese Herbal; Intestinal Mucosa; Male; Organ Size; Peroxidase; Phytotherapy; Polysaccharides; Rats; Rats, Sprague-Dawley; Rheum; Spleen; Superoxide Dismutase; Thymus Gland; Trinitrobenzenesulfonic Acid | 2003 |
Glutathione supplementation improves oxidative damage in experimental colitis.
Topics: Animals; Chronic Disease; Colitis; Colon; Disease Models, Animal; Glutathione; Male; Oxidative Stress; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2003 |
The effects of sodium phosphate and polyethylene glycol-electrolyte bowel preparation solutions on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Therapy, Combination; Electrolytes; Ethanol; Female; Intestinal Mucosa; Phosphates; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Solutions; Therapeutic Irrigation; Trinitrobenzenesulfonic Acid; Ulcer | 2003 |
Specific CTL activity of CD8+ TCR Vbeta14+ T cell in mouse 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis.
Topics: Adoptive Transfer; Animals; CD8-Positive T-Lymphocytes; Clone Cells; Colitis; Female; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes, Cytotoxic; Trinitrobenzenesulfonic Acid | 2003 |
Pancreatic changes in TNBS-induced colitis in mice.
Topics: Animals; Colitis; Mice; Mice, Inbred BALB C; Pancreas; Pancreatitis-Associated Proteins; Trinitrobenzenesulfonic Acid | 2003 |
The cyclo-oxygenase-2 inhibitor, rofecoxib, attenuates mucosal damage due to colitis induced by trinitrobenzene sulphonic acid in rats.
Topics: Animals; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Intestinal Mucosa; Isoenzymes; Lactones; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfones; Trinitrobenzenesulfonic Acid | 2003 |
The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aza Compounds; Azo Compounds; Cell Line; Colitis; Colon; Cytokines; Down-Regulation; Female; Inflammation Mediators; Interleukin-1; Interleukin-8; Mesalamine; Neutrophil Infiltration; Peroxidase; Platelet Activating Factor; Rats; Rats, Wistar; Secondary Prevention; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Concurrent infection with Schistosoma mansoni attenuates inflammation induced changes in colonic morphology, cytokine levels, and smooth muscle contractility of trinitrobenzene sulphonic acid induced colitis in rats.
Topics: Animals; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Peroxidase; Rats; Rats, Wistar; Schistosomiasis mansoni; Spleen; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2004 |
Effects of intrarectal and intraperitoneal N(G)-nitro-L-arginine methyl ester treatment in 2,4,6-trinitrobenzenesulfonic acid induced colitis in rats.
Topics: Acute Disease; Administration, Rectal; Animals; Colitis; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Ethanol; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Rectum; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2003 |
A murine model of chronic inflammation-induced intestinal fibrosis down-regulated by antisense NF-kappa B.
Topics: Animals; Chronic Disease; Colitis; Collagen; Colon; Disease Models, Animal; Female; Fibrosis; Interferon-gamma; Matrix Metalloproteinase 1; Mice; Mice, Inbred BALB C; NF-kappa B; Oligonucleotides, Antisense; RNA, Messenger; Transcription Factor RelA; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2003 |
Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice.
Topics: Animals; Blotting, Western; Colitis; DNA-Binding Proteins; Enzyme Inhibitors; Female; Indoleamine-Pyrrole 2,3,-Dioxygenase; Interferon-gamma; Mice; Mice, Inbred C57BL; Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; STAT1 Transcription Factor; Th1 Cells; Trans-Activators; Trinitrobenzenesulfonic Acid; Tryptophan Oxygenase | 2003 |
A mouse model of intestinal fibrosis?
Topics: Animals; Colitis; Colon; Disease Models, Animal; Fibrosis; Mice; NF-kappa B; Oligonucleotides, Antisense; Transcription Factor RelA; Trinitrobenzenesulfonic Acid | 2003 |
Contrasting roles for CXCR2 during experimental colitis.
Topics: Animals; Antibodies, Blocking; Chemokines, CXC; Colitis; Disease Models, Animal; Intercellular Signaling Peptides and Proteins; Male; Neutrophil Infiltration; Neutrophils; Rats; Rats, Wistar; Receptors, Interleukin-8B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2004 |
Imaging of intestinal lymphocyte homing by means of pinhole SPECT in a TNBS colitis mouse model.
Topics: Animals; Cell Movement; Colitis; Colon; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Lymphocytes; Mice; Mice, Inbred BALB C; Organometallic Compounds; Oxyquinoline; Radiopharmaceuticals; Receptors, Lymphocyte Homing; Tissue Distribution; Tomography, Emission-Computed, Single-Photon; Trinitrobenzenesulfonic Acid | 2004 |
The expression and role of Fas ligand in intestinal inflammation.
Topics: Animals; Blotting, Western; Colitis; Disease Models, Animal; Fas Ligand Protein; Gastrointestinal Transit; Guinea Pigs; Ileitis; Immunohistochemistry; Inflammation; Intestines; Male; Membrane Glycoproteins; Mice; Mice, Transgenic; Myenteric Plexus; Neutrophils; Trinitrobenzenesulfonic Acid | 2004 |
An interleukin 12 p40-IgG2b fusion protein abrogates T cell mediated inflammation: anti-inflammatory activity in Crohn's disease and experimental colitis in vivo.
Topics: Adult; Animals; Apoptosis; Cell Division; Cells, Cultured; Colitis; Crohn Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunoglobulin G; Interferon-gamma; Interleukin-12; Interleukin-12 Subunit p40; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Middle Aged; Prospective Studies; Protein Subunits; Receptors, Interleukin; Receptors, Interleukin-12; Recombinant Fusion Proteins; Trinitrobenzenesulfonic Acid | 2004 |
Effects of low molecular weight heparin on platelet surface P-selectin expression and serum interleukin-8 production in rats with trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Blood Platelets; Colitis; Eosinophils; Female; Heparin, Low-Molecular-Weight; Interleukin-8; Intestinal Mucosa; Monocytes; Neutrophils; P-Selectin; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2004 |
Long-term effects of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension.
Topics: Animals; Biomechanical Phenomena; Colitis; Dilatation, Pathologic; Electromyography; Ethanol; Gastrointestinal Motility; Male; Rats; Rats, Inbred Lew; Rectum; Trinitrobenzenesulfonic Acid | 2004 |
Nitric oxide released by Lactobacillus farciminis improves TNBS-induced colitis in rats.
Topics: Animals; Colitis; Colon; Lactobacillus; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Anti-inflammatory effect of diosmectite in hapten-induced colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Colitis; Cytokines; Disease Models, Animal; Female; Glutathione; Glycoproteins; Haptens; Humans; Interleukin-1; Interleukin-1beta; Intestinal Mucosa; Leukotriene B4; Mucins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peptide Fragments; Rats; Rats, Wistar; Silicates; Trinitrobenzenesulfonic Acid | 2004 |
Neonatal maternal deprivation triggers long term alterations in colonic epithelial barrier and mucosal immunity in rats.
Topics: Animals; Animals, Newborn; Bacterial Translocation; Colitis; Colon; Cytokines; Disease Susceptibility; Female; Immunity, Mucosal; Intestinal Mucosa; Male; Mast Cells; Maternal Deprivation; Permeability; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
1,8-cineole (eucalyptol), a monoterpene oxide attenuates the colonic damage in rats on acute TNBS-colitis.
Topics: Acute Disease; Administration, Rectal; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Eucalyptol; Glutathione; Instillation, Drug; Intestinal Mucosa; Male; Monoterpenes; Organ Size; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Cyclooxygenase-2 contributes to dysmotility and enhanced excitability of myenteric AH neurones in the inflamed guinea pig distal colon.
Topics: Animals; Colitis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Eicosanoids; Electrophysiology; Female; Gastrointestinal Motility; Guinea Pigs; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Male; Muscle, Smooth; Myenteric Plexus; Neurons; Prostaglandin-Endoperoxide Synthases; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2004 |
Decreased availability of intestinal dopamine in transmural colitis may relate to inhibitory effects of interferon-gamma upon L-DOPA uptake.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Caco-2 Cells; Chromatography, High Pressure Liquid; Colitis; Colon; Dopamine; Humans; Ileum; Interferon-gamma; Intestinal Mucosa; Levodopa; Male; Norepinephrine; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Yersinia pseudotuberculosis anti-inflammatory components reduce trinitrobenzene sulfonic acid-induced colitis in the mouse.
Topics: Animals; Colitis; Disease Models, Animal; Female; Humans; Inflammation; Inflammatory Bowel Diseases; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Yersinia pseudotuberculosis; Yersinia pseudotuberculosis Infections | 2004 |
Reduction of Smad3 accelerates re-epithelialization in a murine model of colitis.
Topics: Animals; Cell Division; Colitis; Disease Models, Animal; DNA-Binding Proteins; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Regeneration; Severity of Illness Index; Smad3 Protein; Trans-Activators; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Wound Healing | 2004 |
Expression of apoptosis-related proteins in rat with induced colitis.
Topics: Animals; Antigens, Surface; Apoptosis; Biomarkers; Biopsy; Colitis; Disease Models, Animal; Fas Ligand Protein; fas Receptor; In Situ Nick-End Labeling; Ligands; Male; Membrane Glycoproteins; Rats; Rats, Wistar; Transglutaminases; Trinitrobenzenesulfonic Acid; Tumor Suppressor Protein p53 | 2004 |
The role of intrahepatic CD8+ T cell trapping and NK1.1+ cells in liver-mediated immune regulation.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Immune Tolerance; Killer Cells, Natural; Lectins, C-Type; Liver; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily B; Proteins; Trinitrobenzenesulfonic Acid | 2004 |
Intestinal anti-inflammatory activity of paepalantine, an isocoumarin isolated from the capitula of Paepalanthus bromelioides, in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Antioxidants; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Eriocaulaceae; Female; Gastrointestinal Agents; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Anti-inflammatory effect of acute stress on experimental colitis is mediated by cholecystokinin-B receptors.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Ganglionic Blockers; Hexamethonium; Hypothalamo-Hypophyseal System; Injections, Intraventricular; Intestinal Mucosa; Male; Mifepristone; Neurotransmitter Agents; Pituitary-Adrenal System; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin B; Restraint, Physical; Stress, Physiological; Sympathetic Nervous System; Trinitrobenzenesulfonic Acid | 2004 |
Persistent and selective effects of inflammation on smooth muscle cell contractility in rat colitis.
Topics: Animals; Carbachol; Cells, Cultured; Cholinergic Agonists; Colitis; Dose-Response Relationship, Drug; Histamine; Inflammation; Male; Microscopy, Video; Muscle Contraction; Myocytes, Smooth Muscle; Potassium; Rats; Rats, Sprague-Dawley; Serotonin; Trinitrobenzenesulfonic Acid | 2004 |
Decrease in non-selective, non-sustained attention induced by a chronic visceral inflammatory state as a new pain evaluation in rats.
Topics: Acetaminophen; Analgesics; Animals; Anti-Inflammatory Agents; Aspirin; Attention; Behavior, Animal; Chronic Disease; Cognition Disorders; Colitis; Dose-Response Relationship, Drug; Hyperalgesia; Ibuprofen; Inflammation; Male; Morphine; Pain; Pain Measurement; Physical Stimulation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2004 |
Neuronal activity and CRF receptor gene transcription in the brains of rats with colitis.
Topics: Animals; Colitis; In Situ Hybridization; Male; Neurons; Paraventricular Hypothalamic Nucleus; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2004 |
Inhibition of glycolipid biosynthesis by N-(5-adamantane-1-yl-methoxy-pentyl)-deoxynojirimycin protects against the inflammatory response in hapten-induced colitis.
Topics: 1-Deoxynojirimycin; Adamantane; Animals; Anti-Inflammatory Agents; Antibodies; Body Weight; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Glycolipids; Haptens; Immunoglobulin G; Immunosuppressive Agents; Interferon-gamma; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Oxazolone; Peroxidase; Trinitrobenzenesulfonic Acid | 2004 |
Superoxide dismutase ameliorates TNBS-induced colitis by reducing oxidative stress, adhesion molecule expression, and leukocyte recruitment into the inflamed intestine.
Topics: Animals; Body Weight; Cell Adhesion; Cell Adhesion Molecules; Chemotaxis, Leukocyte; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Intestinal Mucosa; Lipid Peroxidation; Male; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1; Venules | 2004 |
Ameliorating effects of the immunomodulator 3-(2-ethylphenyl)-5-(3-methoxyphenyl)-1H-1,2,4-triazole in an experimental model of colitis in the rat.
Topics: Animals; Body Weight; Colitis; Colon; Cytokines; Diarrhea; Immunohistochemistry; Immunosuppressive Agents; Male; Neutrophil Infiltration; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Triazoles; Trinitrobenzenesulfonic Acid | 2004 |
Blood flow alterations in TNBS-induced colitis: role of endothelin receptors.
Topics: Animals; Antihypertensive Agents; Azepines; Bosentan; Colitis; Inflammation; Male; Mesenteric Arteries; Mucous Membrane; Oligopeptides; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Regional Blood Flow; Sulfonamides; Time Factors; Trinitrobenzenesulfonic Acid | 2004 |
Dietary iron affects inflammatory status in a rat model of colitis.
Topics: Animals; Colitis; Colon; Dose-Response Relationship, Drug; Ferritins; Iron; Iron, Dietary; Kidney; Liver; Male; Malondialdehyde; Osmolar Concentration; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Sulfhydryl Compounds; Trinitrobenzenesulfonic Acid | 2004 |
The role of CCL3/macrophage inflammatory protein-1alpha in experimental colitis.
Topics: Animals; Antibodies; Chemokine CCL3; Chemokine CCL4; Chemokines, CC; Colitis; Colon; Disease Models, Animal; Macrophage Inflammatory Proteins; Male; Neutrophil Infiltration; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2004 |
Pharmacological properties of traditional medicine (XXIX): effect of Hange-shashin-to and the combinations of its herbal constituents on rat experimental colitis.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Colitis; Colon; Disease Models, Animal; Drugs, Chinese Herbal; Male; Peptic Ulcer; Phytotherapy; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
In vivo evaluation of 111In-labeled T-lymphocyte homing in experimental colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Drug Evaluation, Preclinical; Female; Indium Radioisotopes; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Radionuclide Imaging; Receptors, Lymphocyte Homing; Reproducibility of Results; Sensitivity and Specificity; Trinitrobenzenesulfonic Acid | 2004 |
Dietary resistant starch alters the characteristics of colonic mucosa and exerts a protective effect on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Cecum; Colitis; Colon; Dietary Carbohydrates; Fatty Acids; Intestinal Mucosa; Mucins; Peroxidase; Rats; Rats, Wistar; Starch; Trinitrobenzenesulfonic Acid | 2004 |
A beta-oxidation-resistant lipoxin A4 analog treats hapten-induced colitis by attenuating inflammation and immune dysfunction.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Colitis; Female; Haptens; Lipoxins; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Oxidation-Reduction; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2004 |
Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis.
Topics: Animals; Capsaicin; Colitis; Colon; Nociceptors; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2004 |
Beneficial effect of trimebutine and N-monodesmethyl trimebutine on trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Administration, Rectal; Anesthetics, Local; Animals; Bupivacaine; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Gastrointestinal Agents; Injections, Subcutaneous; Lidocaine; Male; Organ Size; Rats; Rats, Sprague-Dawley; Trimebutine; Trinitrobenzenesulfonic Acid | 2004 |
Effects of Boswellia serrata in mouse models of chemically induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Boswellia; Caco-2 Cells; Cell Division; Colitis; Dextran Sulfate; Gene Expression; Humans; Intestinal Mucosa; Liver; Mice; NF-kappa B; Oligonucleotide Array Sequence Analysis; Organ Size; Plant Extracts; Trinitrobenzenesulfonic Acid; Triterpenes; Weight Loss | 2005 |
Uterine motor alterations and estrous cycle disturbances associated with colonic inflammation in the rat.
Topics: Animals; Carbachol; Colitis; Colon; Estrus; Female; In Vitro Techniques; Muscarinic Agonists; Oxytocin; Peroxidase; Potassium Chloride; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Uterine Contraction; Uterus | 2005 |
A role for proteinase-activated receptor-1 in inflammatory bowel diseases.
Topics: Adult; Animals; B-Lymphocytes; Colitis; Colon; Dextran Sulfate; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Humans; Immunohistochemistry; Inflammatory Bowel Diseases; Intestinal Mucosa; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Peptide Fragments; Permeability; Peroxidase; Receptor, PAR-1; RNA, Messenger; Survival Rate; T-Lymphocytes; Thrombin; Trinitrobenzenesulfonic Acid | 2004 |
Ameliorating effect of hepatocyte growth factor on inflammatory bowel disease in a murine model.
Topics: Animals; Apoptosis; Colitis; Colon; Cytokines; Hepatocyte Growth Factor; Humans; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Peroxidase; RNA, Messenger; Transfection; Trinitrobenzenesulfonic Acid; Weight Loss | 2005 |
Stress increases susceptibility to oxidative/nitrosative mucosal damage in an experimental model of colitis in rats.
Topics: Animals; Body Weight; Colitis; Disease Models, Animal; Female; Intestinal Mucosa; Lipid Peroxidation; Nitric Oxide Synthase; Rats; Rats, Wistar; Restraint, Physical; Trinitrobenzenesulfonic Acid | 2004 |
CD40 antisense oligonucleotide inhibition of trinitrobenzene sulphonic acid induced rat colitis.
Topics: Animals; CD40 Antigens; CD40 Ligand; Cells, Cultured; Colitis; Crohn Disease; Drug Design; Gene Expression Regulation; Immunity, Mucosal; Intestinal Mucosa; Liposomes; Male; Muscle, Smooth, Vascular; Oligonucleotides, Antisense; Rats; Rats, Wistar; Transfection; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1 | 2005 |
Effects and mechanism of the selective COX-2 inhibitor, celecoxib, on rat colitis induced by trinitrobenzene sulfonic acid.
Topics: Animals; Celecoxib; Colitis; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Inflammation; Intestinal Mucosa; Male; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2004 |
Selective loss of NGF-sensitive neurons following experimental colitis.
Topics: Animals; Biomarkers; Calbindins; Cell Count; Colitis; Colon; Disease Models, Animal; Enteric Nervous System; Male; Nerve Growth Factor; Neurons; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; S100 Calcium Binding Protein G; Trinitrobenzenesulfonic Acid | 2005 |
[Altered colonic transit in TNBS-induced experimental colitis in guinea pig and distribution of nitric oxide synthase in the colonic wall].
Topics: Animals; Colitis; Colon; Gastrointestinal Transit; Guinea Pigs; Male; Myenteric Plexus; Nitric Oxide Synthase; Trinitrobenzenesulfonic Acid | 2004 |
Regulatory cells induced by feeding TNP-haptenated colonic protein cross-protect mice from colitis induced by an unrelated hapten.
Topics: Adjuvants, Immunologic; Administration, Oral; Animal Feed; Animals; Antigens; Colitis; Colon; Disease Models, Animal; Haptens; Interleukin-10; Male; Mice; Monocytes; Oxazolone; Picrates; Proteins; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2005 |
Therapeutic effect of the immunomodulator glatiramer acetate on trinitrobenzene sulfonic acid-induced experimental colitis.
Topics: Animals; Colitis; Crohn Disease; Disease Models, Animal; Female; Glatiramer Acetate; Immunosuppressive Agents; Mice; Mice, Inbred BALB C; Multiple Sclerosis; Peptides; Polymers; Severity of Illness Index; Survival Analysis; Trinitrobenzenesulfonic Acid | 2005 |
Disturbances in epithelial ionic secretion in different experimental models of colitis.
Topics: Acetic Acid; Acute Disease; Alkylating Agents; Animals; Animals, Genetically Modified; Chloramines; Chronic Disease; Colitis; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Female; HLA-B27 Antigen; Indicators and Reagents; Iodoacetamide; Ions; Oxazolone; Patch-Clamp Techniques; Rats; Trinitrobenzenesulfonic Acid | 2005 |
The presentation of haptenated proteins and activation of T cells in the mesenteric lymph nodes by dendritic cells in the TNBS colitis rat.
Topics: Animals; Colitis; Dendritic Cells; Disease Models, Animal; Haptens; Inflammatory Bowel Diseases; Lymph Nodes; Rats; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2004 |
An improved and reliable method for the induction of colitis in rats using 2,4,6-trinitrobenzene sulfonic acid.
Topics: Animals; Colitis; Disease Models, Animal; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Ulcer; Wound Healing | 2005 |
Therapeutic potential of follistatin for colonic inflammation in mice.
Topics: Animals; Colitis; Colonic Diseases; Female; Follistatin; Inflammation; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2005 |
Amelioration of 2,4,6-trinitrobenzene sulphonic acid induced colitis in angiotensinogen gene knockout mice.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensinogen; Animals; Colitis; Colon; Cytokines; Immunity, Mucosal; Intestinal Mucosa; Losartan; Male; Mice; Mice, Inbred ICR; Mice, Knockout; Renin-Angiotensin System; Trinitrobenzenesulfonic Acid; Weight Loss | 2005 |
Vasoactive intestinal peptide impairs leucocyte migration but fails to modify experimental murine colitis.
Topics: Acute Disease; Animals; Chemotaxis, Leukocyte; Colitis; Infusion Pumps, Implantable; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Models, Animal; Treatment Failure; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2005 |
Preventative effects of lactulose in the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Colitis; Disease Models, Animal; Female; Gastrointestinal Agents; Lactobacillaceae; Lactulose; Leukotriene B4; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Colonic responses to Lactobacillus farciminis treatment in trinitrobenzene sulphonic acid-induced colitis in rats.
Topics: Animals; Bacterial Translocation; Colitis; Gastrointestinal Tract; Interleukin-1; Interleukin-10; Lactobacillus; Male; Permeability; Peroxidase; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2004 |
Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; Colitis; Interleukin-10; Male; Mice; Peptide Fragments; Probiotics; Protein Precursors; Recurrence; T-Lymphocyte Subsets; Th1 Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2005 |
Effect of the macrolide antibacterial drug, tylosin, on TNBS-induced colitis in the rat.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Disease Models, Animal; Male; Metronidazole; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tylosin | 2005 |
Pathophysiological studies of trinitrobenzene sulfonic acid-induced colitis in Syrian hamsters (Mesocricetus auratus).
Topics: Animals; Anti-Inflammatory Agents; Colitis; Colon; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Male; Mesocricetus; Oxadiazoles; Prednisolone; Pyrimidinones; Random Allocation; Trinitrobenzenesulfonic Acid | 2005 |
Therapeutic effect of adenoviral-mediated hepatocyte growth factor gene administration on TNBS-induced colitis in mice.
Topics: Adenoviridae; Administration, Rectal; Animals; Apoptosis; Body Weight; Cell Proliferation; Colitis; Female; Gene Expression; Genetic Therapy; Hepatocyte Growth Factor; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid | 2005 |
Activation of nuclear factor-kappa B and effects of pyrrolidine dithiocarbamate on TNBS-induced rat colitis.
Topics: Animals; Antioxidants; Colitis; Male; NF-kappa B; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiocarbamates; Trinitrobenzenesulfonic Acid | 2005 |
Synaptic facilitation and enhanced neuronal excitability in the submucosal plexus during experimental colitis in guinea-pig.
Topics: Adaptation, Physiological; Animals; Colitis; Colon; Disease Models, Animal; Excitatory Postsynaptic Potentials; Guinea Pigs; Intestinal Mucosa; Male; Neurons; Submucous Plexus; Synaptic Transmission; Trinitrobenzenesulfonic Acid | 2005 |
A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis.
Topics: Animals; Body Weight; Colitis; Disease Models, Animal; Eating; Edema; Enzyme Inhibitors; Female; Group II Phospholipases A2; Humans; Hypertension; Inflammatory Bowel Diseases; Lipopolysaccharides; Neutropenia; Pentanoic Acids; Peroxidase; Phospholipases A; Phospholipases A2; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Preventive and therapeutic effects of NF-kappaB inhibitor curcumin in rats colitis induced by trinitrobenzene sulfonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Curcumin; Cytokines; Cytoplasm; Gene Expression; I-kappa B Proteins; Intestinal Mucosa; Male; NF-kappa B; Rats; Rats, Wistar; Survival Rate; Trinitrobenzenesulfonic Acid | 2005 |
Expression and significance of nuclear factor kappaB p65 in colon tissues of rats with TNBS-induced colitis.
Topics: Animals; Blotting, Western; Colitis; Colon; Female; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Male; NF-kappa B; Peroxidase; Rats; Rats, Sprague-Dawley; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Therapeutic effects of rectal administration of basic fibroblast growth factor on experimental murine colitis.
Topics: Administration, Rectal; Animals; Body Weight; Colitis; Colon; Cytokines; Dextran Sulfate; Female; Fibroblast Growth Factor 2; Gene Expression; Humans; Inflammation Mediators; Intestinal Mucosa; Ki-67 Antigen; Mice; Mice, Inbred C57BL; Organ Size; Recombinant Proteins; Survival Analysis; Trinitrobenzenesulfonic Acid; Wound Healing | 2005 |
Protection against 2,4,6-trinitrobenzenesulphonic acid-induced colonic inflammation in mice by the marine products bolinaquinone and petrosaspongiolide M.
Topics: Animals; Anti-Inflammatory Agents; Calcium-Binding Proteins; Colitis; Cyclooxygenase 2; Dysidea; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Immunohistochemistry; Inflammatory Bowel Diseases; Interleukin-1; Male; Membrane Glycoproteins; Membrane Proteins; Mice; Mice, Inbred BALB C; Nerve Tissue Proteins; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oleanolic Acid; Prostaglandin-Endoperoxide Synthases; Sesquiterpenes; Synaptotagmin I; Synaptotagmins; Trinitrobenzenesulfonic Acid | 2005 |
Bovine glycomacropeptide is anti-inflammatory in rats with hapten-induced colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Base Sequence; Cattle; Colitis; Colon; DNA Primers; Gene Expression Regulation; Glycopeptides; Haptens; Interleukin-1; Necrosis; Polymerase Chain Reaction; Rats; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2005 |
Impaired TGF-beta responses in peripheral T cells of G alpha i2-/- mice.
Topics: Adoptive Transfer; Animals; Colitis; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Immune Tolerance; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Proto-Oncogene Proteins; Smad2 Protein; Smad3 Protein; T-Lymphocyte Subsets; Trans-Activators; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2005 |
Different sensitivity of lamina propria T-cell subsets to nitric oxide-induced apoptosis explains immunomodulatory activity of a nitric oxide-releasing derivative of mesalamine in rodent colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Cells, Cultured; Colitis; Colon; Immunologic Factors; In Vitro Techniques; Interferon-gamma; Interleukin-10; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Mitochondria; Nitric Oxide; Reactive Oxygen Species; T-Lymphocyte Subsets; Th1 Cells; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Differential role of tumor necrosis factor receptors in TNBS colitis.
Topics: Animals; Colitis; Disease Models, Animal; Hypothermia; Mice; Mice, Inbred C57BL; Mortality; Receptors, Tumor Necrosis Factor; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss | 2005 |
The effect of angiotensin-converting enzyme inhibitors on experimental colitis in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Colitis; Collagen; Colon; Disease Models, Animal; Enzyme Inhibitors; Female; Glutathione; Lisinopril; Male; Malondialdehyde; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Disruption of the blood-brain barrier during TNBS colitis.
Topics: Animals; Antigens, Surface; Blood-Brain Barrier; Blotting, Western; Colitis; Fluorescein; Image Processing, Computer-Assisted; Immunoglobulin G; Immunohistochemistry; Infarction, Middle Cerebral Artery; Male; Membrane Proteins; Middle Cerebral Artery; Occludin; Perfusion; Rats; Rats, Sprague-Dawley; Tight Junctions; Trinitrobenzenesulfonic Acid | 2005 |
Lymphtoxin beta receptor-Ig ameliorates TNBS-induced colitis via blocking LIGHT/HVEM signaling.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Disease Models, Animal; Gene Expression Regulation; Immunoglobulins; Interleukin-1; Interleukin-8; Lymphotoxin beta Receptor; Lymphotoxin-alpha; Male; Membrane Proteins; Mesalamine; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; Receptors, Tumor Necrosis Factor, Member 14; Receptors, Virus; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Ligand Superfamily Member 14; Tumor Necrosis Factor-alpha | 2005 |
Effects of acupuncture at GV01 on experimentally induced colitis in rats: possible involvement of the opioid system.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Injections, Subcutaneous; Male; Naloxone; Narcotic Antagonists; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
Effects of Changtai granules, a traditional compound Chinese medicine, on chronic trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Colitis; Diarrhea; Inflammation; Medicine, Chinese Traditional; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
Protective effect of hawthorn fruit on murine experimental colitis.
Topics: Acute Disease; Animals; Anticoagulants; Colitis; Crataegus; Dextran Sulfate; Disease Models, Animal; Female; Fruit; Mice; Mice, Inbred BALB C; Phytotherapy; Plant Preparations; Trinitrobenzenesulfonic Acid | 2005 |
Effect of nor-trimebutine on neuronal activation induced by a noxious stimulus or an acute colonic inflammation in the rat.
Topics: Abdominal Pain; Acetic Acid; Anesthetics, Local; Animals; Colitis; Immunohistochemistry; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Muscle Contraction; Neurons; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Spinal Cord; Trimebutine; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2005 |
Nanoparticles enhance therapeutic efficiency by selectively increased local drug dose in experimental colitis in rats.
Topics: Animals; Colitis; Creatinine; Drug Delivery Systems; Male; Nanostructures; Oxazolone; Rats; Rats, Wistar; Tacrolimus; Trinitrobenzenesulfonic Acid | 2005 |
Divergent changes to muscarinic and serotonergic signalling following colitis.
Topics: Acetylcholine; Animals; Cells, Cultured; Colitis; Male; Muscle Contraction; Muscle, Smooth; Myocytes, Smooth Muscle; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Receptors, Serotonin; Serotonin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2005 |
Fumigaclavine C, an fungal metabolite, improves experimental colitis in mice via downregulating Th1 cytokine production and matrix metalloproteinase activity.
Topics: Acremonium; Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Ergot Alkaloids; Female; Gene Expression Regulation; Gene Expression Regulation, Enzymologic; Indole Alkaloids; Inflammation; Lymph Nodes; Matrix Metalloproteinases; Mice; Mice, Inbred BALB C; Th1 Cells; Trinitrobenzenesulfonic Acid | 2005 |
Amelioration of experimental colitis by Na-H exchanger-1 inhibitor amiloride is associated with reversal of IL-1ss and ERK mitogen-activated protein kinase.
Topics: Amiloride; Animals; Blotting, Western; Colitis; Diuretics; Extracellular Signal-Regulated MAP Kinases; Interleukin-1; Male; Muscle Contraction; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peroxidase; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchangers; Trinitrobenzenesulfonic Acid | 2005 |
Lactobacillus fermentum, a probiotic capable to release glutathione, prevents colonic inflammation in the TNBS model of rat colitis.
Topics: Analysis of Variance; Animals; Colitis; Colony Count, Microbial; Disease Models, Animal; Fatty Acids, Volatile; Female; Glutathione; Inflammation Mediators; Intestinal Mucosa; Leukotriene B4; Limosilactobacillus fermentum; Neutrophil Infiltration; Nitric Oxide Synthase Type II; Oxidative Stress; Peroxidase; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Serotonin transporter function and expression are reduced in mice with TNBS-induced colitis.
Topics: Animals; Colitis; Disease Models, Animal; Enterochromaffin Cells; Immunohistochemistry; Intestinal Mucosa; Mast Cells; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Nerve Tissue Proteins; RNA, Messenger; Serotonin; Serotonin Plasma Membrane Transport Proteins; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2005 |
Thromboxane A2 up-regulates neutrophil elastase release in Syrian hamsters with trinitrobenzene sulfonic acid-induced colitis.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Colitis; Cricetinae; Disease Models, Animal; Leukocyte Elastase; Leukotriene B4; Male; Mesocricetus; Specific Pathogen-Free Organisms; Thromboxane A2; Trinitrobenzenesulfonic Acid; Up-Regulation | 2005 |
Differential responses of intrinsic and extrinsic innervation of smooth muscle cells in rat colitis.
Topics: Animals; Blotting, Western; Colitis; Gene Expression Regulation; In Vitro Techniques; Male; Models, Biological; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Rosette Formation; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine 3-Monooxygenase; Ubiquitin Thiolesterase | 2005 |
Preventative effects of a probiotic, Lactobacillus salivarius ssp. salivarius, in the TNBS model of rat colitis.
Topics: Animals; Colitis; Colon; Female; Intestinal Mucosa; Lactobacillus; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2005 |
The role of the tumor necrosis factor receptor in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in mice.
Topics: Animals; Apoptosis; Colitis; Female; Inflammation; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Receptors, Tumor Necrosis Factor, Type I; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Intestinal inflammation-induced growth retardation acts through IL-6 in rats and depends on the -174 IL-6 G/C polymorphism in children.
Topics: Animals; Antibodies; Case-Control Studies; Child; Colitis; Crohn Disease; Disease Models, Animal; Genotype; Growth Disorders; Humans; Inflammation; Insulin-Like Growth Factor I; Interleukin-6; Intestinal Diseases; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2005 |
Spinal cord stimulation attenuates visceromotor reflexes in a rat model of post-inflammatory colonic hypersensitivity.
Topics: Animals; Colitis; Disease Models, Animal; Electric Stimulation Therapy; Gastrointestinal Motility; Inflammation; Male; Pain; Pain Management; Rats; Rats, Sprague-Dawley; Reflex; Spinal Cord; Trinitrobenzenesulfonic Acid | 2005 |
Experimental colitis in mice and sensitization of converging visceral and somatic afferent pathways.
Topics: Afferent Pathways; Animals; Colitis; Colon; Hindlimb; Hot Temperature; Male; Mice; Nociceptors; Physical Stimulation; Pressure; Rectum; Reflex; Sensory Thresholds; Skin Physiological Phenomena; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urination | 2006 |
Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro.
Topics: Animals; Colitis; Free Radical Scavengers; Hydroxyl Radical; In Vitro Techniques; Male; Malondialdehyde; Melatonin; Nitric Oxide; Peroxidase; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
Role of tumor necrosis factor receptors in an animal model of acute colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Models, Animal; E-Selectin; Female; Gene Expression; Intercellular Adhesion Molecule-1; Intestine, Small; Rats; Rats, Sprague-Dawley; Receptors, Tumor Necrosis Factor; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor Receptor-Associated Peptides and Proteins; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2005 |
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
Topics: Acute Disease; Animals; Benzimidazoles; Body Weight; Colitis; Colon; Dose-Response Relationship, Drug; Indoles; Male; Organ Size; Peroxidase; Piperazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H4; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Role of nitric oxide in the impairment of circular muscle contractility of distended, uninflamed mid-colon in TNBS-induced acute distal colitis in rats.
Topics: Animals; Colitis; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2.
Topics: Animals; Azoxymethane; beta Catenin; Colitis; Colon; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Disease Susceptibility; Intramolecular Oxidoreductases; Lipocalins; Male; Prostaglandin D2; Rats; Rats, Wistar; Receptors, Immunologic; Receptors, Prostaglandin; Trinitrobenzenesulfonic Acid | 2005 |
Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Intestinal Mucosa; Male; Melatonin; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Milk whey culture with Propionibacterium freudenreichii ET-3 is effective on the colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Topics: Acetic Acid; Animals; Cattle; Colitis; Colon; Culture Media; Male; Milk; Probiotics; Propionates; Propionibacterium; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2005 |
[Effects of N-methyl-D-aspartate receptor in visceral, hypersensitivity in rats with colonic inflammation].
Topics: Animals; Colitis; Male; Posterior Horn Cells; Random Allocation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Trinitrobenzenesulfonic Acid | 2005 |
Matrine improves 2,4,6-trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Alkaloids; Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Matrines; Mice; Mice, Inbred BALB C; Neutrophils; Peroxidase; Quinolizines; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Activation of peripheral 5-HT receptors attenuates colonic sensitivity to intraluminal distension.
Topics: Acetic Acid; Animals; Colitis; Colon; Dose-Response Relationship, Drug; Gastrointestinal Agents; Indoles; Injections, Intraventricular; Male; Muscle, Smooth; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin, 5-HT4; Rectum; Serotonin Receptor Agonists; Trinitrobenzenesulfonic Acid | 2006 |
Protective effect of geranylgeranylacetone on trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Body Weight; CD4-Positive T-Lymphocytes; Colitis; Diterpenes; HSP70 Heat-Shock Proteins; Male; Mice; Mice, Inbred BALB C; Organ Size; Peroxidase; Survival Rate; Trinitrobenzenesulfonic Acid | 2006 |
Treatment with Met-RANTES decreases bacterial translocation in experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Bacterial Translocation; Chemokine CCL5; Colitis; Colon; Disease Models, Animal; Male; Noxae; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Up-regulation of anandamide levels as an endogenous mechanism and a pharmacological strategy to limit colon inflammation.
Topics: Adult; Aged; Amidohydrolases; Animals; Arachidonic Acids; Benzenesulfonates; Colitis; Colitis, Ulcerative; Colon; Disease Models, Animal; Drug Evaluation, Preclinical; Endocannabinoids; Female; Glycerides; Humans; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Mesalamine; Mice; Mice, Inbred C57BL; Middle Aged; Peroxidase; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Serotonin; Specific Pathogen-Free Organisms; Trinitrobenzenesulfonic Acid | 2006 |
Selective up-regulation of NMDA-NR1 receptor expression in myenteric plexus after TNBS induced colitis in rats.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Glutamic Acid; Inflammation Mediators; Male; Myenteric Plexus; Neuronal Plasticity; Neurons; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Trinitrobenzenesulfonic Acid; Up-Regulation; Visceral Afferents | 2006 |
Long-term expression of corticotropin-releasing factor (CRF) in the paraventricular nucleus of the hypothalamus in response to an acute colonic inflammation.
Topics: Animals; Autoradiography; Colitis; Corticotropin-Releasing Hormone; Cytokines; Diagnostic Imaging; Electrophoretic Mobility Shift Assay; Gene Expression Regulation; Male; Paraventricular Hypothalamic Nucleus; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Favorable response to subcutaneous administration of infliximab in rats with experimental colitis.
Topics: Animals; Antibodies, Monoclonal; Colitis; Gastrointestinal Agents; Infliximab; Injections, Subcutaneous; Male; Malondialdehyde; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2005 |
Evaluation of 5-aminosalicyltaurine as a colon-specific prodrug of 5-aminosalicylic acid for treatment of experimental colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Colitis; Colon; Drug Delivery Systems; Feces; Gastrointestinal Agents; Intestinal Absorption; Male; Mesalamine; Prodrugs; Rats; Rats, Sprague-Dawley; Sulfasalazine; Taurine; Trinitrobenzenesulfonic Acid | 2006 |
Effect of a novel water-soluble vitamin E derivative as a cure for TNBS-induced colitis in rats.
Topics: Animals; Body Weight; Chromans; Colitis; Colon; Cytokines; Glycosides; Inflammation; Intestinal Mucosa; Male; Peroxidase; Rats; Rats, Wistar; Solubility; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid; Vitamin E | 2006 |
Inflammatory bowel disease requires the interplay between innate and adaptive immune signals.
Topics: Animals; Cells, Cultured; Colitis; Dose-Response Relationship, Drug; Homeodomain Proteins; Immunity, Innate; Inflammatory Bowel Diseases; Interferon-gamma; Lipopolysaccharides; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; omega-N-Methylarginine; Th1 Cells; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid | 2006 |
The effects of resveratrol, a phytoalexin derived from red wines, on chronic inflammation induced in an experimentally induced colitis model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Gene Expression Regulation; Inflammation; Male; Membrane Proteins; NF-kappa B; Peroxidase; Phytoalexins; Prostaglandin D2; Rats; Rats, Wistar; Resveratrol; Sesquiterpenes; Stilbenes; Terpenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Wine | 2006 |
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hydroxamic Acids; Inflammation Mediators; Intestinal Mucosa; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Neutrophils; Pyrazines; Rats; Rats, Sprague-Dawley; Sulfonamides; Trinitrobenzenesulfonic Acid; Up-Regulation | 2006 |
Recommendations for improved use of the murine TNBS-induced colitis model in evaluating anti-inflammatory properties of lactic acid bacteria: technical and microbiological aspects.
Topics: Animals; Colitis; Disease Models, Animal; Female; Lactobacillus plantarum; Lactococcus lactis; Mice; Mice, Inbred BALB C; Probiotics; Reproducibility of Results; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 2006 |
Induction of colitis causes inflammatory responses in fat depots: evidence for substance P pathways in human mesenteric preadipocytes.
Topics: Abdominal Fat; Animals; Cell Differentiation; Cells, Cultured; Chemotaxis; Colitis; Cytokines; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Keratinocytes; Mesentery; Mice; NF-kappa B; Phosphorylation; Receptors, Neurokinin-1; RNA, Messenger; Signal Transduction; Substance P; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Selective COX-2 inhibition reduces leukocyte sticking and improves the microcirculation in TNBS colitis.
Topics: Animals; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Immunohistochemistry; Intestinal Mucosa; Leukocytes; Male; Microcirculation; Nitrobenzenes; Probability; Random Allocation; Rats; Rats, Sprague-Dawley; Reference Values; Regional Blood Flow; Sensitivity and Specificity; Sulfonamides; Tissue Adhesions; Trinitrobenzenesulfonic Acid | 2006 |
[Correlation of intestinal mucosal injury with serum diamine oxidase].
Topics: Amine Oxidase (Copper-Containing); Animals; Biomarkers; Colitis; Disease Models, Animal; Enema; Immunohistochemistry; Intestinal Mucosa; Male; Random Allocation; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Spectrophotometry; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model.
Topics: Abdominal Muscles; Acute Disease; Animals; Catheterization; Colitis; Colon; Dilatation, Pathologic; Disease Models, Animal; Electromyography; Enzyme-Linked Immunosorbent Assay; Hyperalgesia; Interleukin-2; Interleukin-6; Intestinal Mucosa; Irritable Bowel Syndrome; Male; Rats; Rats, Inbred Lew; Rectum; Sensation Disorders; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Critical role of IL-17 receptor signaling in acute TNBS-induced colitis.
Topics: Animals; Colitis; Colon; Inflammation; Interleukin-17; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interleukin; Signal Transduction; Trinitrobenzenesulfonic Acid | 2006 |
The neutrophil/Th1 lymphocyte balance and the therapeutic effect of granulocyte colony-stimulating factor in TNBS-induced colitis of rat strains.
Topics: Animals; Colitis; Granulocyte Colony-Stimulating Factor; Humans; Lipopolysaccharides; Male; Neutrophils; Rats; Recombinant Proteins; RNA, Messenger; Survival Rate; Th1 Cells; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Anti-inflammatory potential of the probiotic dietary supplement Lactibiane Tolérance: in vitro and in vivo considerations.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Cells, Cultured; Colitis; Cytokines; Dietary Supplements; Disease Models, Animal; Female; Humans; Inflammatory Bowel Diseases; Lactobacillus; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Probiotics; Random Allocation; Severity of Illness Index; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2006 |
Role of TNF-alpha in muscularis inflammation and motility disorder in a TNBS-induced colitis model: clues from TNF-alpha-deficient mice.
Topics: Animals; Colitis; Disease Models, Animal; Gastrointestinal Motility; Inflammation; Interleukin-1; Interleukin-6; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle, Smooth; Peroxidase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Curcumin; Cyclooxygenase 2; Cytokines; Dexamethasone; Dinoprostone; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Gene Expression; PPAR gamma; Prostaglandin D2; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Specific Pathogen-Free Organisms; Time Factors; Trinitrobenzenesulfonic Acid; Weight Loss | 2006 |
Anti-tryptase treatment using nafamostat mesilate has a therapeutic effect on experimental colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamidines; Chemokine CXCL1; Chemokines, CXC; Colitis; Colon; Guanidines; Intestinal Mucosa; Male; Rats; Rats, Wistar; Serine Proteinase Inhibitors; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid; Tryptases; Tumor Necrosis Factor-alpha | 2006 |
Effects of statins on experimental colitis in normocholesterolemic rats.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Colitis; Collagen; Colon; Fatty Acids, Monounsaturated; Fluvastatin; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Luminescence; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Simvastatin; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Gliotoxin reduces the severity of trinitrobenzene sulfonic acid-induced colitis in mice: evidence of the connection between heme oxygenase-1 and the nuclear factor-kappaB pathway in vitro and in vivo.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Caco-2 Cells; Colitis; Gliotoxin; Heme Oxygenase-1; Humans; Immunosuppressive Agents; Inflammation; Intercellular Adhesion Molecule-1; Interleukin-8; Mice; NF-kappa B; Peroxidase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2.
Topics: Animals; Body Weight; Chronic Disease; Colitis; Colon; Curcumin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Gene Expression Regulation, Enzymologic; Interferon-gamma; Intestinal Mucosa; Leukocytes; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Mechanism underlying the reversal of contractility dysfunction in experimental colitis by cyclooxygenase-2 inhibition.
Topics: Animals; Blotting, Western; Carbachol; Colitis; Colon; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Gastrointestinal Motility; Isometric Contraction; Male; Malondialdehyde; Meloxicam; Muscle, Smooth; p38 Mitogen-Activated Protein Kinases; Peroxidase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thiazines; Thiazoles; Trinitrobenzenesulfonic Acid | 2006 |
Galanin in the trinitrobenzene sulfonic acid rat model of experimental colitis.
Topics: Animals; Body Weight; Colitis; Female; Galanin; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Colon; Curcumin; Cytokines; Dexamethasone; Interferon-gamma; Interleukin-12; Intestinal Mucosa; Peroxidase; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Endothelin-1 receptor antagonist (LU-135252) improves the microcirculation and course of TNBS colitis in rats.
Topics: Animals; Blood Flow Velocity; Capillary Permeability; Colitis; Colon; Disease Models, Animal; Endothelin A Receptor Antagonists; Male; Microcirculation; Phenylpropionates; Pyrimidines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2006 |
Short-chain fructooligosaccharides, in spite of being fermented in the upper part of the large intestine, have anti-inflammatory activity in the TNBS model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Bifidobacterium; Colitis; Colon; Colony Count, Microbial; Fatty Acids, Volatile; Female; Fermentation; Hydrogen-Ion Concentration; Ileum; Kinetics; Lactobacillus; Oligosaccharides; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Intestinal antiinflammatory activity of a lyophilized infusion of Turnera ulmifolia in TNBS rat colitis.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Freeze Drying; Gastrointestinal Agents; Phytotherapy; Plant Components, Aerial; Plant Extracts; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Turnera | 2006 |
Protection from experimental colitis by theaflavin-3,3'-digallate correlates with inhibition of IKK and NF-kappaB activation.
Topics: Animals; Biflavonoids; Biotransformation; Catechin; Cell Nucleus; Colitis; Cytoplasm; Ether; Female; Flavonoids; Gallic Acid; I-kappa B Proteins; Interferon-gamma; Interleukin-12; Macrophages; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Peroxidase; Phenols; Polyphenols; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Anti-inflammatory activity of a pteridine derivative (4AZA2096) alleviates TNBS-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Antibodies; Cells, Cultured; Colitis; Colon; Cytokines; Humans; Interleukin-1; Leukocytes, Mononuclear; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Peroxidase; Pteridines; RNA, Messenger; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Effect of VIP on TLR2 and TLR4 expression in lymph node immune cells during TNBS-induced colitis.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Movement; Colitis; Dendritic Cells; Disease Models, Animal; Lymph Nodes; Macrophages; Mice; Toll-Like Receptor 2; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2006 |
Identification of Card15/Nod2 mRNA in intestinal tissue of experimentally induced colitis in rats.
Topics: Animals; Base Sequence; Colitis; Colon; Gene Expression Regulation; Intracellular Signaling Peptides and Proteins; Male; Nod2 Signaling Adaptor Protein; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2006 |
The new low calcemic vitamin D analog 22-ene-25-oxa-vitamin D prominently ameliorates T helper cell type 1-mediated colitis in mice.
Topics: Animals; Calcitriol; Calcium; Colitis; Creatinine; Interleukin-10; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Receptors, Calcitriol; Th1 Cells; Trinitrobenzenesulfonic Acid; Vitamin D | 2006 |
Antisense therapy of MAdCAM-1 for trinitrobenzenesulfonic acid-induced murine colitis.
Topics: Animals; B-Lymphocytes; Cell Adhesion Molecules; Cell Line; Colitis; Colon; Endothelial Cells; Feasibility Studies; Mice; Mice, Inbred BALB C; Mucoproteins; Oligonucleotides; Oligonucleotides, Antisense; RNA, Messenger; Trinitrobenzenesulfonic Acid; Wasting Syndrome | 2006 |
ADOA3R as a therapeutic target in experimental colitis: proof by validated high-density oligonucleotide microarray analysis.
Topics: Adenosine; Adenosine A3 Receptor Agonists; Animals; Colitis; Disease Models, Animal; Free Radicals; Gene Expression Regulation; Glutathione Peroxidase; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2006 |
Sensitization of pelvic nerve afferents and mast cell infiltration in the urinary bladder following chronic colonic irritation is mediated by neuropeptides.
Topics: Anesthesia; Anesthetics, Intravenous; Animals; Bradykinin; Capsaicin; Chronic Disease; Colitis; Cystitis, Interstitial; Female; Mast Cells; Nerve Endings; Nerve Fibers, Unmyelinated; Neurons, Afferent; Neuropeptides; Pelvis; Physical Stimulation; Rats; Rats, Sprague-Dawley; Substance P; Trinitrobenzenesulfonic Acid; Urethane; Urinary Bladder | 2007 |
The effect of melatonin on TNBS-induced colitis.
Topics: Analysis of Variance; Animals; Antioxidants; Apoptosis; Caspase 3; Caspases; Colitis; Colon; Glutathione; Intestinal Mucosa; Male; Malondialdehyde; Melatonin; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Paeonol attenuates TNBS-induced colitis by inhibiting NF-kappaB and STAT1 transactivation.
Topics: Acetophenones; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dose-Response Relationship, Drug; Female; Gene Expression Regulation, Enzymologic; Humans; Interferon-gamma; Jurkat Cells; Mice; Mice, Inbred BALB C; NF-kappa B; Nitric Oxide Synthase Type II; Promoter Regions, Genetic; RNA, Messenger; STAT1 Transcription Factor; Transcriptional Activation; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Phosphorylation of NMDA NR1 subunits in the myenteric plexus during TNBS induced colitis.
Topics: Alkaline Phosphatase; Animals; Blotting, Western; Colitis; Disease Models, Animal; Electrophoresis, Gel, Two-Dimensional; Gene Expression; Male; Myenteric Plexus; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Selecting lactic acid bacteria for their safety and functionality by use of a mouse colitis model.
Topics: Acute Disease; Animals; Bacterial Adhesion; Caco-2 Cells; Colitis; Disease Models, Animal; Female; Gastrointestinal Tract; Humans; In Vitro Techniques; Lactobacillus; Mice; Mice, Inbred BALB C; Probiotics; Safety; Trinitrobenzenesulfonic Acid | 2006 |
The effect of glutamine on pancreatic damage in TNBS-induced colitis.
Topics: Animals; Caspase 3; Colitis; Glutamine; Glutathione; Male; Malondialdehyde; NF-kappa B; Pancreas; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Involvement of cannabinoid receptors in inflammatory hypersensitivity to colonic distension in rats.
Topics: Animals; Benzoxazines; Calcium Channel Blockers; Camphanes; Colitis; Colon; Dose-Response Relationship, Drug; Indoles; Inflammation; Male; Manometry; Morpholines; Muscle Contraction; Muscle, Smooth; Naphthalenes; Nociceptors; Pain; Piperidines; Pressure; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Rimonabant; Trinitrobenzenesulfonic Acid | 2006 |
Mucosal function in rat jejunum and ileum is altered by induction of colitis.
Topics: Aminopeptidases; Animals; Colitis; Colon; Gene Expression; Goblet Cells; Ileum; Intestinal Mucosa; Jejunum; Male; Microvilli; Mucins; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sucrase-Isomaltase Complex; Trinitrobenzenesulfonic Acid | 2006 |
Acute distal colitis impairs gastric emptying in rats via an extrinsic neuronal reflex pathway involving the pelvic nerve.
Topics: Acute Disease; Analgesics, Non-Narcotic; Animals; Capsaicin; Colitis; Ganglia, Spinal; Ganglionic Blockers; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Transit; Gastroparesis; Hexamethonium; Immunohistochemistry; Intestinal Mucosa; Male; Neural Pathways; Neurons; Pelvis; Peroxidase; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2007 |
Neonatal immune challenge exacerbates experimental colitis in adult rats: potential role for TNF-alpha.
Topics: Animals; Animals, Newborn; Body Temperature; Circadian Rhythm; Colitis; Corticosterone; Female; Immunity; Lipopolysaccharides; Pregnancy; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Weight Loss | 2007 |
A traditional Japanese medicine mitigates TNBS-induced colitis in rats.
Topics: Animals; Aspergillus oryzae; Body Weight; Colitis; Colon; Enema; Feces; In Vitro Techniques; Interleukin-1beta; Intestinal Mucosa; Japan; Macrophages; Male; Medicine, East Asian Traditional; Organ Size; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Zinc | 2006 |
Persistent alterations to enteric neural signaling in the guinea pig colon following the resolution of colitis.
Topics: Action Potentials; Animals; Bethanechol; Body Weight; Cell Count; Colforsin; Colitis; Colon; Enteric Nervous System; Enteroendocrine Cells; Excitatory Postsynaptic Potentials; Glucagon-Like Peptide 2; Guinea Pigs; Male; Membrane Potentials; Neurons; Peptide YY; Peroxidase; Serotonin; Serotonin Plasma Membrane Transport Proteins; Submucous Plexus; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Veratridine | 2007 |
The effect of octreotide on pancreatic damage in TNBS-induced colitis.
Topics: Animals; Colitis; Gastrointestinal Agents; Glutathione; Male; Malondialdehyde; NF-kappa B; Octreotide; Oxidative Stress; Pancreatitis; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
Molecular profiling of a rat model of colitis: validation of known inflammatory genes and identification of novel disease-associated targets.
Topics: Animals; Biomarkers; Colitis; Disease Models, Animal; Electronic Data Processing; Female; Gene Expression Profiling; Inflammation Mediators; Oligonucleotide Array Sequence Analysis; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid | 2006 |
Different susceptibilities of spontaneous rhythmicity and myogenic contractility to intestinal muscularis inflammation in the hapten-induced colitis.
Topics: Animals; Colitis; Cytokines; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Gastrointestinal Motility; Gene Expression; Haptens; Immunohistochemistry; Inflammation; Intestinal Mucosa; Male; Muscle Contraction; Muscle, Smooth; Peroxidase; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2006 |
Polyethylene glycol enhances colonic barrier function and ameliorates experimental colitis in rats.
Topics: Animals; Cathartics; Colitis; Colon; Hydrophobic and Hydrophilic Interactions; Inflammation Mediators; Intestinal Mucosa; Male; Polyethylene Glycols; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Weight Gain | 2007 |
Experimental colitis: decreased Octn2 and Atb0+ expression in rat colonocytes induces carnitine depletion that is reversible by carnitine-loaded liposomes.
Topics: Amino Acid Sequence; Amino Acid Transport System ASC; Animals; Base Sequence; Butyric Acid; Carnitine; Colitis; Liposomes; Molecular Sequence Data; Neurotransmitter Transport Proteins; Organic Cation Transport Proteins; Rats; Rats, Wistar; Solute Carrier Family 22 Member 5; Trinitrobenzenesulfonic Acid | 2006 |
Immunosuppressive activity of a new pteridine derivative (4AZA1378) alleviates severity of TNBS-induced colitis in mice.
Topics: Animals; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunosuppressive Agents; Jurkat Cells; Male; Mice; Mice, Inbred C57BL; Peroxidase; Pteridines; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2007 |
Improvement of an experimental colitis in rats by lactic acid bacteria producing superoxide dismutase.
Topics: Administration, Oral; Animals; Cattle; Colitis; Immunohistochemistry; Lactobacillus; Male; Peroxidase; Probiotics; Random Allocation; Rats; Rats, Wistar; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2006 |
Interleukin-6 genetic ablation protects from trinitrobenzene sulfonic acid-induced colitis in mice. Putative effect of antiinflammatory cytokines.
Topics: Animals; Body Weight; Chemotaxis, Leukocyte; Colitis; Colon; Disease Models, Animal; Eating; Female; Interleukin-10; Interleukin-6; Mice; Mice, Inbred C57BL; Mice, Knockout; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Up-Regulation | 2006 |
Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases.
Topics: Adoptive Transfer; Animals; Arthritis, Experimental; Cell Line; Colitis; Fibroblasts; Flow Cytometry; Humans; In Situ Hybridization; Interleukin-1beta; Interleukin-6; Interleukins; Leukocytes, Mononuclear; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Synovial Membrane; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Antibodies to complement receptor 3 treat established inflammation in murine models of colitis and a novel model of psoriasiform dermatitis.
Topics: Adoptive Transfer; Animals; Antibodies; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dermatitis; Disease Models, Animal; Female; Inflammation Mediators; Injections, Intravenous; Macrophage-1 Antigen; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Nude; Psoriasis; Trinitrobenzenesulfonic Acid | 2006 |
Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis.
Topics: Animals; Colitis; Disease Models, Animal; Down-Regulation; Female; Gene Expression Regulation; Male; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotides, Antisense; Signal Transduction; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2006 |
Therapeutic treatment of experimental colitis with regulatory dendritic cells generated with vasoactive intestinal peptide.
Topics: Animals; Autoimmunity; CD4-Positive T-Lymphocytes; Cell Transplantation; Cells, Cultured; Colitis; Dendritic Cells; Disease Models, Animal; Immune Tolerance; Immunotherapy; Interleukin-10; Mice; Mice, Inbred BALB C; Th1 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2006 |
Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis.
Topics: Animals; Apoptosis; Cell Separation; Colitis; Colon; Cytokines; Inflammation; Intestinal Mucosa; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred BALB C; Oligonucleotides, Antisense; Phosphoproteins; STAT3 Transcription Factor; Trinitrobenzenesulfonic Acid; Weight Loss | 2007 |
Long-term study of TNBS-induced colitis in rats: focus on mast cells.
Topics: Animals; Cell Degranulation; Colitis; Colon; Male; Mast Cells; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2006 |
The effect of heme oxygenase-1 induction by glutamine on TNBS-induced colitis. The effect of glutamine on TNBS colitis.
Topics: Animals; Caspase 3; Colitis; Enzyme Induction; Glutamine; Glutathione; Heme Oxygenase-1; Immunohistochemistry; Intestinal Mucosa; Male; Malondialdehyde; NF-kappa B; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2007 |
Mechanism of reduced colonic contractility in experimental colitis: role of sarcoplasmic reticulum pump isoform-2.
Topics: Animals; Body Weight; Carbachol; Colitis; Dose-Response Relationship, Drug; Gastrointestinal Motility; Gene Expression Regulation, Enzymologic; In Vitro Techniques; Isoenzymes; Male; Muscle Contraction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Trinitrobenzenesulfonic Acid | 2007 |
Vanin-1 licenses inflammatory mediator production by gut epithelial cells and controls colitis by antagonizing peroxisome proliferator-activated receptor gamma activity.
Topics: Active Transport, Cell Nucleus; Amidohydrolases; Animals; Benzhydryl Compounds; Body Weight; Cell Adhesion Molecules; Cell Line; Cell Nucleus; Chemokine CCL2; Chemokine CXCL2; Chemokines; Colitis; Colon; Cyclooxygenase 2; Cystamine; Cytokines; Epithelial Cells; Epoxy Compounds; Gene Expression Regulation; GPI-Linked Proteins; Interleukin-1beta; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, SCID; PPAR gamma; Prostaglandin D2; Survival Analysis; Trinitrobenzenesulfonic Acid | 2006 |
Signal transducer and activator of transcription 5b promotes mucosal tolerance in pediatric Crohn's disease and murine colitis.
Topics: Animals; Carrier Proteins; Child; Colitis; Colon; Crohn Disease; Epithelial Cells; Female; Genetic Predisposition to Disease; Humans; Hypoglycemic Agents; Intestinal Mucosa; Male; Mice; Mice, Inbred C57BL; Mucous Membrane; NF-kappa B; PPAR gamma; Rosiglitazone; Signal Transduction; STAT5 Transcription Factor; Thiazolidinediones; Trinitrobenzenesulfonic Acid | 2006 |
Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Gene Expression; Inflammatory Bowel Diseases; Leukocyte Common Antigens; Mice; Mice, Inbred BALB C; Mice, SCID; Oligonucleotide Array Sequence Analysis; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2007 |
Remission-inducing effect of anti-TNF monoclonal antibody in TNBS colitis: mechanisms beyond neutralization?
Topics: Amino Acid Chloromethyl Ketones; Animals; Antibodies, Monoclonal; Apoptosis; Caspase Inhibitors; Colitis; Down-Regulation; Inflammatory Bowel Diseases; Infliximab; Interferon-gamma; Interleukin-18; Male; Mice; Mice, Inbred C57BL; Oxazolone; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
A comparative study of the preventative effects exerted by two probiotics, Lactobacillus reuteri and Lactobacillus fermentum, in the trinitrobenzenesulfonic acid model of rat colitis.
Topics: Animals; Colitis; Colon; Diarrhea; Fatty Acids, Volatile; Feces; Female; Gastrointestinal Contents; Glutathione; Hydrogen-Ion Concentration; Inflammatory Bowel Diseases; Intestinal Mucosa; Limosilactobacillus fermentum; Limosilactobacillus reuteri; Models, Animal; Muscle, Skeletal; Organ Size; Peroxidase; Probiotics; Rats; Rats, Wistar; Spleen; Thymus Gland; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria.
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Humans; Lactobacillus; Leukocytes, Mononuclear; Mice; Mice, Inbred BALB C; Probiotics; Trinitrobenzenesulfonic Acid | 2007 |
Immunomodulatory effects of ciprofloxacin in TNBS-induced colitis in mice.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents; Ceftazidime; Ciprofloxacin; Colitis; Colon; Cytokines; Dexamethasone; Female; Inflammation; Mice; Mice, Inbred BALB C; NF-kappa B; Organ Size; Spleen; Trinitrobenzenesulfonic Acid; Weight Loss | 2007 |
Adiponectin deficiency protects mice from chemically induced colonic inflammation.
Topics: Adiponectin; Animals; Chemokine CXCL2; Chemokines; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Epidermal Growth Factor; Female; Fibroblast Growth Factor 2; Heparin-binding EGF-like Growth Factor; Intercellular Signaling Peptides and Proteins; Interleukin-6; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Receptors, Adiponectin; Receptors, Cell Surface; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
MIP-3alpha neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice.
Topics: Animals; Antibodies, Monoclonal; CD4 Lymphocyte Count; CD8 Antigens; Chemokine CCL20; Chemokines, CC; Colitis; Colonic Diseases; Intestinal Mucosa; Macrophage Inflammatory Proteins; Male; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid; Up-Regulation | 2007 |
Pharmacological and biochemical characterization of bradykinin B2 receptors in the mouse colon: influence of the TNBS-induced colitis.
Topics: Acetylcholine; Animals; Bradykinin; Bradykinin B2 Receptor Antagonists; Calcium Channels, L-Type; Calcium Channels, N-Type; Colitis; Colon; Dose-Response Relationship, Drug; Kallidin; Leukotrienes; Male; Mice; Muscle Contraction; Neuropeptides; Prostaglandins; Quinolines; Receptor, Bradykinin B2; Trinitrobenzenesulfonic Acid | 2007 |
Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis.
Topics: Animals; Chronic Disease; Colitis; Curcumin; Cyclooxygenase 2; Female; Gene Expression Regulation, Enzymologic; Male; MAP Kinase Signaling System; Nitric Oxide; Nitric Oxide Synthase Type II; p38 Mitogen-Activated Protein Kinases; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Corticosterone; Dextran Sulfate; Disease Models, Animal; Estradiol; Estrous Cycle; Female; Gonadal Steroid Hormones; Immunohistochemistry; Interleukin-1beta; Intramolecular Oxidoreductases; Macrophage Migration-Inhibitory Factors; Ovariectomy; Peroxidase; Progesterone; Rats; Rats, Wistar; Severity of Illness Index; Sex Factors; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Chronic administration of galanin attenuates the TNBS-induced colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Cyclooxygenase 2; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Galanin; Injections, Intraperitoneal; Male; Mast Cells; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Enhanced activity of a hydrogen sulphide-releasing derivative of mesalamine (ATB-429) in a mouse model of colitis.
Topics: Animals; Anti-Inflammatory Agents; Chemokines; Colitis; Colon; Cytokines; Disease Models, Animal; Disulfides; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Granulocytes; Hydrogen Sulfide; Mesalamine; Mice; Mice, Inbred BALB C; RNA, Messenger; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Bile synthesis in rat models of inflammatory bowel diseases.
Topics: Animals; Bile Acids and Salts; Colitis; Dextran Sulfate; Indomethacin; Inflammatory Bowel Diseases; Male; Models, Biological; NF-kappa B; Rats; Rats, Wistar; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2007 |
Synaptic plasticity in myenteric neurons of the guinea-pig distal colon: presynaptic mechanisms of inflammation-induced synaptic facilitation.
Topics: Animals; Colitis; Colon; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Electric Stimulation; Enzyme Activation; Evoked Potentials; Excitatory Postsynaptic Potentials; Guinea Pigs; Isoquinolines; Large-Conductance Calcium-Activated Potassium Channels; Microscopy, Electron, Transmission; Myenteric Plexus; Neuronal Plasticity; Peptides; Potassium Channel Blockers; Presynaptic Terminals; Protein Kinase Inhibitors; Sulfonamides; Synaptic Transmission; Synaptic Vesicles; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Role of calcitonin receptor-like receptor in colonic motility and inflammation.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Receptor-Like Protein; Colitis; Colon; Gastrointestinal Motility; Male; Rats; Rats, Sprague-Dawley; Receptors, Calcitonin; RNA Interference; RNA, Double-Stranded; Trinitrobenzenesulfonic Acid | 2007 |
PARP inhibition reduces acute colonic inflammation in rats.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gastrointestinal Agents; Isoquinolines; Membrane Proteins; Niacinamide; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
The bisphosphonate alendronate improves the damage associated with trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Administration, Oral; Alendronate; Animals; Anti-Inflammatory Agents; Body Weight; Bone Density Conservation Agents; Chemokine CCL2; Colitis; Colon; Diphosphonates; Dose-Response Relationship, Drug; Female; Gastrointestinal Agents; Gene Expression; Injections, Intraperitoneal; Interleukin 1 Receptor Antagonist Protein; Interleukin-1beta; Rats; Rats, Wistar; Sulfasalazine; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2007 |
The role of adiponectin in colitis.
Topics: Adiponectin; Animals; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Gastrointestinal Agents; Interleukin-8; Intestinal Mucosa; Mice; Research Design; Trinitrobenzenesulfonic Acid | 2007 |
Enhanced expression of mast cell growth factor and mast cell activation in the bladder following the resolution of trinitrobenzenesulfonic acid (TNBS) colitis in female rats.
Topics: Animals; Colitis; Disease Models, Animal; Female; Mast Cells; Nerve Growth Factors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stem Cell Factor; Trinitrobenzenesulfonic Acid; Urinary Bladder; Urination | 2007 |
Sinomenine attenuates 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in mice.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Colitis; Colon; Enzyme-Linked Immunosorbent Assay; Female; Interferon-gamma; Mice; Mice, Inbred BALB C; Morphinans; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Effects of Ginkgo biloba extract on inflammatory mediators (SOD, MDA, TNF-alpha, NF-kappaBp65, IL-6) in TNBS-induced colitis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Base Sequence; Colitis; Ginkgo biloba; Inflammation Mediators; Interleukin-6; Male; Malondialdehyde; Mesalamine; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase; Transcription Factor RelA; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2006 |
Chemically induced mouse models of intestinal inflammation.
Topics: Animals; Colitis; Dextran Sulfate; Disease Models, Animal; Epithelial Cells; Mice; Oxazolone; Trinitrobenzenesulfonic Acid | 2007 |
R-spondin1, a novel intestinotrophic mitogen, ameliorates experimental colitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Proliferation; Colitis; Colon; Cytokines; Dextran Sulfate; Disease Models, Animal; Female; Immunohistochemistry; Intestinal Mucosa; Intestine, Small; Mice; Mice, Inbred BALB C; Mitogens; Piroxicam; Plasma Substitutes; Recombinant Proteins; Severity of Illness Index; Thrombospondins; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2007 |
Erdosteine prevents colonic inflammation through its antioxidant and free radical scavenging activities.
Topics: Acridines; Animals; Antioxidants; Colitis; Collagen; Colon; Disease Models, Animal; DNA Fragmentation; Enzyme-Linked Immunosorbent Assay; Expectorants; Female; Free Radical Scavengers; Glutathione; Luminescence; Luminol; Malondialdehyde; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Severity of Illness Index; Thioglycolates; Thiophenes; Trinitrobenzenesulfonic Acid | 2007 |
Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis.
Topics: Animals; Colitis; Fibrosis; Interferon-gamma; Interleukin-13; Interleukin-13 Receptor alpha2 Subunit; Interleukins; Mice; Mice, Inbred BALB C; Phosphorylation; Receptors, Interleukin-13; RNA, Small Interfering; Smad3 Protein; Smad7 Protein; Th1 Cells; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2007 |
Inducible nitric oxide synthase from bone marrow-derived cells plays a critical role in regulating colonic inflammation.
Topics: Animals; Bone Marrow Cells; Bone Marrow Transplantation; Chemokines; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Acid; Nitric Oxide Synthase Type II; Trinitrobenzenesulfonic Acid | 2007 |
Active hexose correlated compound acts as a prebiotic and is antiinflammatory in rats with hapten-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Bacteria, Aerobic; Bifidobacterium; Colitis; Colon; Colony Count, Microbial; Female; Haptens; Lactobacillus; Polysaccharides; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2007 |
Therapeutic and prophylactic thalidomide in TNBS-induced colitis: synergistic effects on TNF-alpha, IL-12 and VEGF production.
Topics: Animals; CD4-Positive T-Lymphocytes; Colitis; Colon; Gene Expression Regulation; Immunosuppressive Agents; Interleukin-12; Intestinal Mucosa; Macrophages; Male; Rats; Rats, Wistar; Thalidomide; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2007 |
Visceral and somatic hypersensitivity in a subset of rats following TNBS-induced colitis.
Topics: Animals; Colitis; Hot Temperature; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Somatosensory Disorders; Touch; Trinitrobenzenesulfonic Acid; Visceral Afferents | 2008 |
Antiinflammatory activity of an herbal preparation (HemoHIM) in rats.
Topics: Administration, Oral; Angelica; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cnidium; Colitis; Cotton Fiber; Edema; Granuloma, Foreign-Body; Male; Paeonia; Phytotherapy; Plant Preparations; Plant Roots; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Rhizome; Trinitrobenzenesulfonic Acid | 2007 |
Colon-specific, mutual azo prodrug of 5-aminosalicylic acid with L-tryptophan: synthesis, kinetic studies and evaluation of its mitigating effect in trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Azo Compounds; Body Weight; Colitis; Kinetics; Mesalamine; Molecular Structure; Organ Size; Prodrugs; Rats; Trinitrobenzenesulfonic Acid; Tryptophan | 2007 |
Chronic inflammation alters the contribution of neurokinin receptor subtypes to epithelial function in rat colon.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Benzamides; Colitis; Disease Models, Animal; Indomethacin; Intestinal Mucosa; Male; Neurokinin A; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Receptors, Neurokinin-2; Receptors, Neurokinin-3; Receptors, Tachykinin; Stereoisomerism; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2008 |
Up-regulation of nerve growth factor and interleukin-10 in inflamed and non-inflamed intestinal segments in rats with experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Interleukin-10; Intestine, Small; Iodoacetamide; Nerve Growth Factor; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Up-Regulation | 2007 |
The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23-->IL-17 axis.
Topics: Animals; Anti-Ulcer Agents; Colitis; Colon; Cytokines; Dendritic Cells; Dinoprostone; Disease Models, Animal; Inflammatory Bowel Diseases; Interleukin-12; Interleukin-17; Interleukin-23; Interleukins; Intestinal Mucosa; Lipopolysaccharides; Male; Mice; Mice, Inbred BALB C; Misoprostol; Neutrophils; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2007 |
Tanshinone IIA ameliorates trinitrobenzene sulfonic acid (TNBS)-induced murine colitis.
Topics: Abietanes; Actins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Blotting, Western; Colitis; Colon; Dose-Response Relationship, Drug; Glutathione; Immunohistochemistry; Interleukin-1beta; Male; Mice; Mice, Inbred BALB C; NF-kappa B; Peroxidase; Phenanthrenes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
The effect of restraint stress on the normal colon and on intestinal inflammation in a model of experimental colitis.
Topics: Animals; Biomarkers; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Female; Intestinal Mucosa; Malondialdehyde; Oxidative Stress; Radioimmunoassay; Rats; Restraint, Physical; Severity of Illness Index; Stress, Physiological; Substance P; Trinitrobenzenesulfonic Acid | 2008 |
15-deoxyspergualin prevents mucosal injury by inhibiting production of TNF-alpha and down-regulating expression of MD-1 in a murine model of TNBS-induced colitis.
Topics: Administration, Rectal; Animals; Antigens, CD19; Antigens, Surface; Apoptosis; B-Lymphocytes; Cell Proliferation; Colitis; Colon; Disease Models, Animal; Down-Regulation; Female; Guanidines; Immunosuppressive Agents; Injections, Intraperitoneal; Interferon-gamma; Intestinal Mucosa; Membrane Glycoproteins; Mice; Mice, Inbred BALB C; Toll-Like Receptors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Hyperthermia ameliorates 2,4,6-trinitrobenzene sulphonic acid-induced colitis in rats: the role of heat shock proteins.
Topics: Animals; Anti-Ulcer Agents; Body Temperature; Colitis; Colon; Diterpenes; Enzyme Inhibitors; Fever; Heat-Shock Proteins; Male; Peroxidase; Protoporphyrins; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis.
Topics: Animals; Colitis; Colon; Corticotropin-Releasing Hormone; Disease Models, Animal; Gastrointestinal Tract; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Urocortins | 2007 |
Sympathetic vasoconstrictor regulation of mouse colonic submucosal arterioles is altered in experimental colitis.
Topics: Adenosine Triphosphate; Adrenergic Agents; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arterioles; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Enteric Nervous System; Guanethidine; Intestinal Mucosa; Male; Mice; Microscopy, Video; Norepinephrine; Phenylephrine; Prazosin; Purinergic P2 Receptor Antagonists; Receptors, Adrenergic, alpha-1; Receptors, Purinergic P2; Receptors, Purinergic P2X; Suramin; Sympathetic Nervous System; Tetrodotoxin; Time Factors; Trinitrobenzenesulfonic Acid; Up-Regulation; Vasoconstriction | 2007 |
Acetate inhibits NFAT activation in T cells via importin beta1 interference.
Topics: Acetic Acid; Animals; Anti-Inflammatory Agents; beta Karyopherins; Colitis; Dermatitis; Dinitrofluorobenzene; Enzyme Activation; Fatty Acids, Volatile; Female; Humans; Interleukin-2; Jurkat Cells; Mice; Mice, Inbred BALB C; NF-kappa B; NFATC Transcription Factors; Protein Transport; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2007 |
Acupuncture at GV01 relieves somatic pain referred by colitis in rats.
Topics: Acupuncture Points; Acupuncture Therapy; Animals; Colitis; Immunohistochemistry; Male; Naloxone; Neurons; Pain Threshold; Pain, Referred; Periaqueductal Gray; Proto-Oncogene Proteins c-fos; Random Allocation; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
2',4',6'-tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-alpha-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways.
Topics: Animals; Cell Line; Chalcone; Colitis; Epithelium; Heme Oxygenase-1; Inflammation; Intestines; Mice; Mucous Membrane; Protective Agents; Signal Transduction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Prevention and treatment of colitis with Lactococcus lactis secreting the immunomodulatory Yersinia LcrV protein.
Topics: Administration, Oral; Animals; Antigens, Bacterial; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Female; Interleukin-10; Intestinal Mucosa; Lactococcus lactis; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Pore Forming Cytotoxic Proteins; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid | 2007 |
Regional difference in the healing process of colitis induced by 2,4,6-trinitrobenzene sulfonic acid in rats.
Topics: Animals; Colitis; Colon; Dinoprostone; Disease Models, Animal; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2007 |
Visceral and somatic hypersensitivity in TNBS-induced colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Hyperalgesia; Male; Rats; Rats, Sprague-Dawley; Touch; Trinitrobenzenesulfonic Acid; Viscera; Visceral Afferents | 2008 |
Cutting edge: The IkappaB kinase (IKK) inhibitor, NEMO-binding domain peptide, blocks inflammatory injury in murine colitis.
Topics: Animals; Colitis; Cytokines; Dextran Sulfate; Disease Models, Animal; I-kappa B Kinase; Lipopolysaccharides; Mice; Mice, Inbred C57BL; NF-kappa B; Peptides; Trinitrobenzenesulfonic Acid | 2007 |
Gastrointestinal distribution and absorption behavior of Eudragit-coated chitosan-prednisolone conjugate microspheres in rats with TNBS-induced colitis.
Topics: Acrylates; Administration, Oral; Animals; Anti-Inflammatory Agents; Area Under Curve; Biological Availability; Cecum; Chitosan; Colitis; Colon; Gastric Mucosa; Hydrogen-Ion Concentration; Intestinal Absorption; Intestine, Small; Male; Microscopy, Electron, Scanning; Microspheres; Particle Size; Pharmaceutical Vehicles; Polymers; Prednisolone; Rats; Rats, Wistar; Surface Properties; Tissue Distribution; Trinitrobenzenesulfonic Acid | 2008 |
Changes in urinary bladder smooth muscle function in response to colonic inflammation.
Topics: Animals; Carbachol; Cholinergic Agonists; Colitis; Electric Stimulation; Enema; Male; Mucous Membrane; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rats; Rats, Sprague-Dawley; Recovery of Function; Time Factors; Trinitrobenzenesulfonic Acid; Urinary Bladder | 2007 |
The role of transient receptor potential vanilloid 1 in mechanical and chemical visceral hyperalgesia following experimental colitis.
Topics: Animals; Capsaicin; Colitis; Disease Models, Animal; Drug Administration Schedule; Drug Interactions; Electromyography; Ganglia, Spinal; Gastrointestinal Motility; Hyperalgesia; Male; Neurons; Rats; Rats, Sprague-Dawley; Reflex, Abdominal; Sulfonamides; Thiourea; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels; Visceral Afferents | 2007 |
The intestinal anti-inflammatory effects of the novel agent UR-1505 in the TNBS model of rat colitis are mediated by T-lymphocyte inhibition.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Colon; Crohn Disease; Disease Models, Animal; Female; Glutathione; Interferon-gamma; Leukotriene B4; Macrophages; Mice; Mice, Inbred BALB C; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Salicylates; Spleen; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
Influence of the H3/H4 receptor antagonist, thioperamide on regional haemodynamics in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Blood Circulation; Colitis; Histamine Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, Histamine; Receptors, Histamine H3; Receptors, Histamine H4; Regional Blood Flow; Trinitrobenzenesulfonic Acid | 2007 |
Altered protein profile of lymphocytes in an antigen-specific model of colitis: a comparative proteomic study.
Topics: Animals; Apoptosis; Blood Proteins; Colitis; Disease Models, Animal; Lymphocyte Activation; Lymphocytes; Male; Oxidative Stress; Proteomics; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trinitrobenzenesulfonic Acid | 2007 |
5-amino salicylic acid bound nanoparticles for the therapy of inflammatory bowel disease.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Caco-2 Cells; Cell Survival; Chemistry, Pharmaceutical; Colitis; Colon; Delayed-Action Preparations; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Carriers; Drug Compounding; Feasibility Studies; Gastrointestinal Agents; Humans; Male; Mice; Mice, Inbred C57BL; Nanoparticles; Particle Size; Peroxidase; Polyesters; Solubility; Technology, Pharmaceutical; Time Factors; Trinitrobenzenesulfonic Acid | 2007 |
Immune modulatory treatment of trinitrobenzene sulfonic acid colitis with calcitriol is associated with a change of a T helper (Th) 1/Th17 to a Th2 and regulatory T cell profile.
Topics: Animals; Anti-Inflammatory Agents; Calcitriol; Calcium; Cell Differentiation; Colitis; Colon; Creatinine; Cytokines; Dexamethasone; Disease Models, Animal; Glucocorticoids; Immunologic Factors; Male; Mice; Mice, Inbred BALB C; Peroxidase; T-Lymphocytes; T-Lymphocytes, Regulatory; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2008 |
Alpha-lipoic acid modulates gut inflammation induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Colitis; Colon; Disease Models, Animal; Gastrointestinal Agents; Glutathione; Ileitis; Ileum; Lipid Peroxidation; Malondialdehyde; Neutrophil Infiltration; Neutrophils; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Thioctic Acid; Trinitrobenzenesulfonic Acid | 2007 |
NOD2 transgenic mice exhibit enhanced MDP-mediated down-regulation of TLR2 responses and resistance to colitis induction.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Cells, Cultured; Colitis; Down-Regulation; Frameshift Mutation; Immunity, Innate; Interleukin-12; Mice; Mice, Inbred C57BL; Mice, Transgenic; Monocytes; NF-kappa B; Nod2 Signaling Adaptor Protein; Peptidoglycan; Plasmids; Spleen; Toll-Like Receptor 2; Trinitrobenzenesulfonic Acid | 2007 |
Hyperbaric oxygen therapy is as effective as dexamethasone in the treatment of TNBS-E-induced experimental colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Dexamethasone; Female; Hyperbaric Oxygenation; Male; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Influence of simultaneous inhibition of cyclooxygenase-2 and inducible nitric oxide synthase in experimental colitis in rats.
Topics: Animals; Catalase; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Intestine, Large; Lactones; Lipid Peroxidation; Male; Nitrates; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Inbred Strains; Sulfones; Superoxide Dismutase; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
The effect of the cholinergic anti-inflammatory pathway on experimental colitis.
Topics: Anabasine; Animals; Blotting, Western; Chlorisondamine; Cholinergic Agonists; Colitis; Disease Models, Animal; Inflammation; Male; Mice; NF-kappa B; Nicotinic Antagonists; Peroxidase; Reverse Transcriptase Polymerase Chain Reaction; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2007 |
The effects of caffeic acid phenethyl ester (CAPE) on TNBS-induced colitis in ovariectomized rats.
Topics: Animals; Caffeic Acids; Catalase; Colitis; Female; Glutathione; Malondialdehyde; Ovary; Peroxidase; Phenylethyl Alcohol; Rats; Rats, Wistar; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid | 2008 |
Changtai granule, a traditional Chinese drug, protects hapten-induced colitis by attenuating inflammatory and immune dysfunctions.
Topics: Animals; Colitis; Enzyme-Linked Immunosorbent Assay; Euphorbia; Haptens; Inflammation; Intestinal Mucosa; Male; Medicine, Chinese Traditional; Phellodendron; Plant Preparations; Polygonum; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sanguisorba; Trinitrobenzenesulfonic Acid | 2008 |
Changes in colonic motility and the electrophysiological properties of myenteric neurons persist following recovery from trinitrobenzene sulfonic acid colitis in the guinea pig.
Topics: Animals; Colitis; Electrophysiology; Excitatory Postsynaptic Potentials; Female; Gastrointestinal Motility; Guinea Pigs; Male; Myenteric Plexus; Neurons; Trinitrobenzenesulfonic Acid | 2007 |
MCP-1 targeting inhibits muscularis macrophage recruitment and intestinal smooth muscle dysfunction in colonic inflammation.
Topics: Animals; Antibodies; Cell Differentiation; Chemokine CCL2; Chemotaxis, Leukocyte; Colitis; Fluorescent Antibody Technique; Inflammation Mediators; Macrophages; Male; Microscopy, Electron, Transmission; Monocytes; Muscle, Smooth; Myenteric Plexus; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
TRPV1 receptor signaling mediates afferent nerve sensitization during colitis-induced motility disorders in rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Calcitonin Gene-Related Peptide Receptor Antagonists; Capsaicin; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Ganglia, Spinal; Gastric Emptying; Gastrointestinal Motility; Gastroparesis; Intestinal Mucosa; Intestines; Male; Muscle Relaxation; Neurons, Afferent; Peptide Fragments; Pyrazines; Pyridines; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; RNA, Messenger; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid; TRPV Cation Channels | 2008 |
Prolonged chronic inflammation progresses to dysplasia in a novel rat model of colitis-associated colon cancer.
Topics: 1,2-Dimethylhydrazine; Adenomatous Polyposis Coli Protein; Animals; Carcinoma; Chronic Disease; Colitis; Colonic Neoplasms; Exons; Inflammation; Inflammatory Bowel Diseases; Mutation; Rats; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Suppressor Protein p53 | 2007 |
Therapeutic effect of epigallocatechin-3-gallate in a mouse model of colitis.
Topics: Animals; Antioxidants; Catechin; Colitis; Cytokines; Disease Models, Animal; Injections, Intraperitoneal; Mice; Mice, Inbred C57BL; Neutrophil Infiltration; NF-kappa B; Peroxidase; Tea; Transcription Factor AP-1; Trinitrobenzenesulfonic Acid | 2008 |
Role of Ca2+-sensitization in attenuated carbachol-induced contraction of the colon in a rat model of colitis.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Colitis; Colon; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Protein Kinase C; Rats; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Trinitrobenzenesulfonic Acid | 2008 |
Simvastatin attenuates trinitrobenzene sulfonic acid-induced colitis, but not oxazalone-induced colitis.
Topics: Animals; Colitis; Cytokines; Enzyme-Linked Immunosorbent Assay; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Male; Mice; Oxazolone; Simvastatin; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid | 2008 |
Lactobacillus fermentum ACA-DC 179 displays probiotic potential in vitro and protects against trinitrobenzene sulfonic acid (TNBS)-induced colitis and Salmonella infection in murine models.
Topics: Animals; Antibiosis; Cell-Free System; Colitis; Colony Count, Microbial; Cytokines; Disease Models, Animal; Female; Food Microbiology; Humans; Hydrogen-Ion Concentration; Lactobacillus plantarum; Leukocytes, Mononuclear; Limosilactobacillus fermentum; Mice; Mice, Inbred BALB C; Probiotics; Salmonella Infections; Streptococcus; Trinitrobenzenesulfonic Acid | 2008 |
Down-regulation of hepatic cytochrome P450 enzymes in rats with trinitrobenzene sulfonic acid-induced colitis.
Topics: Animals; Colitis; Cytochrome P-450 Enzyme System; Down-Regulation; Intestinal Mucosa; Isoenzymes; Liver; Liver Diseases; Male; Peroxidase; Rats; Trinitrobenzenesulfonic Acid | 2008 |
Hind paw incision in the rat produces long-lasting colon hypersensitivity.
Topics: Animals; Colitis; Disease Models, Animal; Hindlimb; Hyperalgesia; Male; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors; Trinitrobenzenesulfonic Acid; Viscera | 2008 |
Relative quantification of mRNA: comparison of methods currently used for real-time PCR data analysis.
Topics: Animals; Colitis; Computational Biology; Cytokines; Data Interpretation, Statistical; Fluorescence; Gene Expression Profiling; Linear Models; Male; Mice; Mice, Inbred BALB C; Models, Animal; Reference Standards; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2007 |
Glucocorticoid availability in colonic inflammation of rat.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; 11-beta-Hydroxysteroid Dehydrogenase Type 2; Animals; Budesonide; Carbenoxolone; Colitis; Colon; Corticosterone; Cyclooxygenase 2; Disease Models, Animal; Glucocorticoids; Hormone Antagonists; Interleukin-1beta; Male; Mifepristone; Mucin-2; Mucins; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Attenuation of inflammation and cytokine production in rat colitis by a novel selective inhibitor of leukotriene A4 hydrolase.
Topics: Administration, Oral; Animals; Benzothiazoles; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Delivery Systems; Enzyme Inhibitors; Epoxide Hydrolases; Inflammation; Interleukin-6; Male; Peroxidase; Piperidines; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Effects of Lactobacillus salivarius 433118 on intestinal inflammation, immunity status and in vitro colon function in two mouse models of inflammatory bowel disease.
Topics: Animals; Cell Membrane Permeability; Colitis; Colon; Cytokines; Disease Models, Animal; Feces; Immunity; Inflammatory Bowel Diseases; Interleukin-10; Lactobacillus; Mannitol; Mice; Mice, Inbred C57BL; Mice, Knockout; Probiotics; Trinitrobenzenesulfonic Acid | 2008 |
Effect of n-3 polyunsaturated fatty acids on membrane microdomain localization of tight junction proteins in experimental colitis.
Topics: Animals; Blotting, Western; Claudin-1; Colitis; Colon; Male; Membrane Microdomains; Membrane Proteins; Microscopy, Electron, Transmission; Occludin; Phosphoproteins; Random Allocation; Rats; Rats, Wistar; Tight Junctions; Trinitrobenzenesulfonic Acid; Zonula Occludens-1 Protein | 2008 |
Suppression of colon inflammation by CD80 blockade: evaluation in two murine models of inflammatory bowel disease.
Topics: Adoptive Transfer; Animals; B7-1 Antigen; Binding, Competitive; Colitis; Colon; Cytokines; Female; Inflammation; Inflammatory Bowel Diseases; Lymphocyte Activation; Mice; Mice, Inbred C57BL; Mice, SCID; Oligopeptides; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2008 |
Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis.
Topics: Acetylmuramyl-Alanyl-Isoglutamine; Adjuvants, Immunologic; Animals; Colitis; Crohn Disease; Cytokines; Dendritic Cells; Disease Models, Animal; Disease Susceptibility; Down-Regulation; Immunity, Innate; Interferon Regulatory Factors; Ligands; Mice; Mice, Mutant Strains; Nod2 Signaling Adaptor Protein; RNA, Small Interfering; Toll-Like Receptors; Trinitrobenzenesulfonic Acid | 2008 |
Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent.
Topics: Animals; Colitis; Concanavalin A; Curcumin; Diet; Disease Models, Animal; Inflammatory Bowel Diseases; Lymphocytes; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Microarray Analysis; Reverse Transcriptase Polymerase Chain Reaction; Species Specificity; Trinitrobenzenesulfonic Acid | 2008 |
Anti-inflammatory properties of lactic acid bacteria producing superoxide dismutase.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Interleukin-10; Lactobacillus; Mice; Mice, Knockout; Probiotics; Reactive Oxygen Species; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 2008 |
Impairment and restoration of spontaneous contractile activity of longitudinal smooth muscles in the TNBS-inflamed hamster distal colon.
Topics: Animals; Colitis; Colon; Cricetinae; Diarrhea; Electric Stimulation; Gastrointestinal Motility; Muscle Contraction; Muscle, Smooth; Trinitrobenzenesulfonic Acid | 2007 |
Prolonged elevation of galanin and tachykinin expression in mucosal and myenteric enteric nerves in trinitrobenzene sulphonic acid colitis.
Topics: Animals; Colitis; Galanin; Immunohistochemistry; Intestinal Mucosa; Male; Myenteric Plexus; Neurofilament Proteins; Neuropeptides; Rats; Rats, Sprague-Dawley; Substance P; Trinitrobenzenesulfonic Acid; Ubiquitin Thiolesterase | 2008 |
The involvement of heme oxygenase-1 activity in the therapeutic actions of 5-aminosalicylic acid in rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Blotting, Western; Colitis; Disease Models, Animal; Heme Oxygenase-1; Male; Mesalamine; Peroxidase; Protoporphyrins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 2008 |
The effects of intra-rectal and intra-peritoneal application of Origanum onites L. essential oil on 2,4,6-trinitrobenzenesulfonic acid-induced colitis in the rat.
Topics: Administration, Rectal; Animals; Antioxidants; Colitis; Colitis, Ulcerative; Colon; Dexamethasone; Disease Models, Animal; Ethanol; Gas Chromatography-Mass Spectrometry; Immunohistochemistry; Injections, Intraperitoneal; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Oils, Volatile; Origanum; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Effects of borneol and thymoquinone on TNBS-induced colitis in mice.
Topics: Animals; Benzoquinones; Body Weight; Camphanes; Colitis; Colon; Cytokines; DNA; DNA Restriction Enzymes; Gene Expression Regulation; Male; Mice; Organ Size; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
Impaired acetylcholine-induced smooth muscle contraction in colitis involves altered calcium mobilization and AKT phosphorylation.
Topics: Acetylcholine; Animals; Blotting, Western; Calcium Signaling; Colitis; Colon; Disease Models, Animal; Male; Microscopy, Fluorescence; Microscopy, Video; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Muscle Contraction; Phosphorylation; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Signal Transduction; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats.
Topics: Animals; Apoptosis; Bacterial Translocation; Caspase 3; Colitis; Colon; Endotoxins; Humans; Male; Melatonin; Peroxidase; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice.
Topics: Adjuvants, Immunologic; Animals; Antibodies, Monoclonal; CD30 Ligand; Colitis; Cytokines; Disease Models, Animal; Genetic Predisposition to Disease; Inflammatory Bowel Diseases; Interleukin-4; Intestinal Mucosa; Ki-1 Antigen; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Oxazolone; Signal Transduction; Trinitrobenzenesulfonic Acid | 2008 |
Effects of a combination of thyme and oregano essential oils on TNBS-induced colitis in mice.
Topics: Animals; Body Weight; Colitis; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Inflammation; Interleukin-1beta; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Oils, Volatile; Origanum; Thymus Plant; Trinitrobenzenesulfonic Acid | 2007 |
Resistin-like molecule beta regulates intestinal mucous secretion and curtails TNBS-induced colitis in mice.
Topics: Animals; Blotting, Western; Calcium; Carbachol; Cells, Cultured; Colitis; Gastrins; Gene Expression; Goblet Cells; Hormones, Ectopic; Humans; Intercellular Signaling Peptides and Proteins; Intestinal Mucosa; Intestines; Mice; Mucin 5AC; Mucin-2; Mucins; Mucus; Protein Kinase C; Protein Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats.
Topics: Animals; Apoptosis; Bombesin; Caspase 3; Colitis; Colon; Interleukin-6; Male; Malondialdehyde; Neurotensin; Oxidative Stress; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2008 |
Control of IFN-alphaA by CD73: implications for mucosal inflammation.
Topics: 5'-Nucleotidase; Acute Disease; Adenosine Diphosphate; Animals; Colitis; Disease Progression; Down-Regulation; Inflammation Mediators; Interferon-alpha; Interleukin-10; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
VIP balances innate and adaptive immune responses induced by specific stimulation of TLR2 and TLR4.
Topics: Animals; Cells, Cultured; Colitis; Disease Models, Animal; Immunity, Cellular; Immunity, Innate; Lymph Nodes; Male; Mesentery; Mice; Mice, Inbred BALB C; Models, Immunological; Time Factors; Toll-Like Receptor 2; Toll-Like Receptor 4; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 2008 |
Differential changes in brain-derived neurotrophic factor and extracellular signal-regulated kinase in rat primary afferent pathways with colitis.
Topics: Afferent Pathways; Animals; Brain-Derived Neurotrophic Factor; Colitis; Colon; Enzyme Activation; Ganglia, Spinal; Lumbosacral Region; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinase 7; Phosphorylation; Rats; Rats, Sprague-Dawley; Spinal Cord; Trinitrobenzenesulfonic Acid | 2008 |
Inflammation causes expression of NGF in epithelial cells of the rat colon.
Topics: Animals; Colitis; Disease Models, Animal; ELAV Proteins; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Gene Expression Regulation; Male; Mucous Membrane; Nerve Growth Factor; Neurons; PC12 Cells; Rats; Rats, Sprague-Dawley; Receptor, Nerve Growth Factor; Receptor, trkA; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Efficacy and toxicity of Eudragit-coated chitosan-succinyl-prednisolone conjugate microspheres using rats with 2,4,6-trinitrobenzenesulfonic acid-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Body Weight; Chitosan; Colitis; Drug Delivery Systems; Intestinal Absorption; Intestinal Mucosa; Male; Microscopy, Electron, Scanning; Microspheres; Organ Size; Particle Size; Polymethacrylic Acids; Prednisolone; Rats; Rats, Wistar; Tissue Distribution; Trinitrobenzenesulfonic Acid | 2008 |
Regulation of gut inflammation and th17 cell response by interleukin-21.
Topics: Animals; CD4-Positive T-Lymphocytes; Cells, Cultured; Colitis; Dextran Sulfate; Disease Models, Animal; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Gene Expression; Humans; Interleukin-17; Interleukin-2 Receptor alpha Subunit; Interleukins; Intestinal Mucosa; Mice; Mice, Inbred C57BL; Mice, Knockout; Polymerase Chain Reaction; RNA; T-Lymphocyte Subsets; T-Lymphocytes, Helper-Inducer; Trinitrobenzenesulfonic Acid | 2008 |
Experimental colitis is associated with ultrastructural changes in inflamed and uninflamed regions of the gastrointestinal tract.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Endoplasmic Reticulum; Golgi Apparatus; Ileum; Inflammation; Male; Microscopy, Electron, Transmission; Mitochondria; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2008 |
Redirection of regulatory T cells with predetermined specificity for the treatment of experimental colitis in mice.
Topics: Animals; Bystander Effect; CD28 Antigens; Cell Line; Cell Movement; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Histocompatibility Antigens; Immunity, Mucosal; Immunoglobulin Variable Region; Immunotherapy, Adoptive; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Transgenic; Oxazolone; Picrates; Receptors, Antigen, T-Cell; Receptors, IgG; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Induction of TNBS colitis in mice.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Leukocytes, Mononuclear; Lymph Nodes; Mice; Mucous Membrane; Trinitrobenzenesulfonic Acid | 2002 |
[Suppression of Schistosoma japonicum eggs on TNBS-induced colitis in mice].
Topics: Animals; Colitis; Colon; Cytokines; Disease Models, Animal; Female; Mice; Mice, Inbred BALB C; Ovum; Schistosoma japonicum; Trinitrobenzenesulfonic Acid | 2007 |
[Mechanism of exacerbation of colonic damage in experimental colitis treated with celecoxib].
Topics: Animals; Celecoxib; Colitis; Colon; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Male; Pyrazoles; Random Allocation; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2008 |
Protease-activated receptor-2 activation: a major actor in intestinal inflammation.
Topics: Animals; Cell Adhesion Molecules; Colitis; Dextran Sulfate; Disease Models, Animal; Mice; Mice, Inbred C57BL; Oxazolone; Peroxidase; Prostaglandin-Endoperoxide Synthases; Receptor, PAR-2; Trinitrobenzenesulfonic Acid | 2008 |
Beta-glycosphingolipids-mediated lipid raft alteration is associated with redistribution of NKT cells and increased intrahepatic CD8+ T lymphocyte trapping.
Topics: Animals; CD4-CD8 Ratio; CD8-Positive T-Lymphocytes; Colitis; Cytokines; Glycosphingolipids; Killer Cells, Natural; Liver; Male; Membrane Microdomains; Mice; Mice, Inbred C57BL; Spleen; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2008 |
Strategies to cure experimental autoimmune colitis using antigen-specific Foxp3+ regulatory T cells.
Topics: Animals; Autoimmune Diseases; Bystander Effect; Cell Movement; Colitis; Colon; Disease Models, Animal; Forkhead Transcription Factors; Immunity, Mucosal; Immunotherapy, Adoptive; Intestinal Mucosa; Lymphocyte Activation; Mice; Mice, Transgenic; Oxazolone; Picrates; Receptors, Antigen, T-Cell; Recombinant Fusion Proteins; T-Lymphocytes, Regulatory; Time Factors; Trinitrobenzenesulfonic Acid | 2008 |
Prevention of colonic fibrosis by Boswellia and Scutellaria extracts in rats with colitis induced by 2,4,5-trinitrobenzene sulphonic acid.
Topics: Actins; Animals; Boswellia; CD3 Complex; Colitis; Collagen Type I; Collagen Type II; Collagen Type III; Colon; Connective Tissue Growth Factor; Crohn Disease; Fibrosis; Immediate-Early Proteins; Immunohistochemistry; Intercellular Signaling Peptides and Proteins; Male; Models, Animal; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley; Scutellaria; Smad3 Protein; Smad7 Protein; Transforming Growth Factor beta1; Trinitrobenzenesulfonic Acid | 2008 |
Targeting endocannabinoid degradation protects against experimental colitis in mice: involvement of CB1 and CB2 receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Colitis; Crohn Disease; Disease Models, Animal; Endocannabinoids; Humans; Mice; Mice, Inbred C57BL; Polymorphism, Genetic; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2008 |
In utero and postnatal exposure to a phytoestrogen-enriched diet increases parameters of acute inflammation in a rat model of TNBS-induced colitis.
Topics: Acute Disease; Animal Feed; Animals; Colitis; Colon; Cyclooxygenase 2; Diet; Disease Models, Animal; Female; Organ Size; Peroxidase; Phytoestrogens; Pregnancy; Pregnancy, Animal; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Uterus | 2008 |
Non-lymphoid cells in experimental inflammatory bowel disease.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Dendritic Cells; Disease Models, Animal; Ethanol; Histocompatibility Antigens Class II; Inflammatory Bowel Diseases; Intestinal Mucosa; Macrophages; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in rats.
Topics: Animals; Blotting, Northern; Colitis; Colon; Disease Models, Animal; Enzyme Induction; Female; Gene Expression Regulation, Enzymologic; Neutrophils; Nitrates; Nitric Oxide Synthase; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; RNA, Messenger; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 1995 |
The selective beneficial effects of nitric oxide inhibition in experimental colitis.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Body Weight; Colitis; Colon; Eating; Hyperplasia; Hypertrophy; Intestines; Male; Muscle, Smooth; Myenteric Plexus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Manipulation of the L-arginine-nitric oxide pathway in experimental colitis.
Topics: Administration, Oral; Administration, Topical; Animals; Arginine; Colitis; Colon; Female; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
Annexin 1 is overexpressed and specifically secreted during experimentally induced colitis in rats.
Topics: Animals; Annexin A1; Annexins; Colitis; Extracellular Space; Kinetics; Male; Molecular Weight; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 1995 |
Experimental colitis is ameliorated by inhibition of nitric oxide synthase activity.
Topics: Animals; Arginine; Calmodulin-Binding Proteins; Capsaicin; Colitis; Disease Models, Animal; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Transmucosal potential difference in experimental colitis in rats.
Topics: Animals; Colitis; Colitis, Ulcerative; Fibrosis; Intestinal Mucosa; Leukotriene B4; Leukotrienes; Male; Membrane Potentials; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
A stable nitroxide radical effectively decreases mucosal damage in experimental colitis.
Topics: Acetates; Animals; Antioxidants; Colitis; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Intestinal Mucosa; Leukotriene B4; Leukotriene C4; Lipoxygenase; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Spin Labels; Time Factors; Trinitrobenzenesulfonic Acid | 1995 |
Antibodies to interleukin 12 abrogate established experimental colitis in mice.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; CD4 Lymphocyte Count; Colitis; Colon; Crohn Disease; Disease Models, Animal; Interferon-gamma; Interleukin-12; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Molecular Sequence Data; Spleen; Trinitrobenzenesulfonic Acid | 1995 |
Transforming growth factor-beta gene therapy ameliorates experimental colitis in rats.
Topics: Animals; Colitis; DNA, Complementary; Genetic Therapy; Genetic Vectors; Male; Rats; Rats, Inbred Strains; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 1995 |
Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents; Chymases; Colitis; Colon; Haptens; Male; Peroxidase; Rats; Rats, Wistar; Recurrence; Serine Endopeptidases; Trinitrobenzenesulfonic Acid | 1995 |
Experimental colitis alters myenteric nerve function at inflamed and noninflamed sites in the rat.
Topics: Adrenergic Fibers; Animals; Colitis; Colon; Ileum; Intestinal Diseases, Parasitic; Male; Myenteric Plexus; Norepinephrine; Peroxidase; Rats; Rats, Sprague-Dawley; Trichinella spiralis; Trichinellosis; Trinitrobenzenesulfonic Acid | 1995 |
Attenuation of epithelial injury in acute experimental colitis by immunomodulators.
Topics: Animals; Colitis; Colon; Cyclosporine; Disease Models, Animal; Epithelium; Immunosuppressive Agents; Male; Misoprostol; Neutrophils; Permeability; Peroxidase; Rabbits; Tacrolimus; Trinitrobenzenesulfonic Acid | 1993 |
Platelet-activating factor mediates trinitrobenzene induced colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Azepines; Colitis; Colon; Dinoprostone; Eicosanoids; Gastrointestinal Contents; Leukotriene B4; Platelet Activating Factor; Rabbits; Second Messenger Systems; Thromboxane B2; Triazoles; Trinitrobenzenesulfonic Acid | 1994 |
Non-lymphoid cells in acute and chronic experimental inflammatory bowel disease.
Topics: Acute Disease; Administration, Rectal; Animals; Antibodies, Monoclonal; Chronic Disease; Colitis; Dendritic Cells; Disease Models, Animal; Histocompatibility Antigens Class II; Inflammatory Bowel Diseases; Lymphocyte Subsets; Lymphoid Tissue; Macrophage-1 Antigen; Macrophages; Neutrophils; Peyer's Patches; Rats; Rats, Wistar; Severity of Illness Index; Trinitrobenzenesulfonic Acid | 1994 |
Disruption of colonic electrolyte transport in experimental colitis.
Topics: Animals; Biological Transport; Colitis; Colon; Dinoprostone; Electrolytes; Leukotriene B4; Male; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 1995 |
BPC-15 reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
Topics: Amino Acid Sequence; Animals; Colitis; Male; Molecular Sequence Data; Peptide Fragments; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Alterations in rat peripheral blood neutrophil function as a consequence of colitis.
Topics: Animals; Chemotaxis, Leukocyte; Colitis; Inflammatory Bowel Diseases; Leukocyte Count; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phagocytosis; Rats; Rats, Wistar; Superoxides; Trinitrobenzenesulfonic Acid | 1995 |
Non-lymphoid and lymphoid cells in acute, chronic and relapsing experimental colitis.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Ethanol; Granulocytes; Immunoenzyme Techniques; Lymphocyte Subsets; Macrophages; Male; Rats; Rats, Wistar; Recurrence; Trinitrobenzenesulfonic Acid | 1995 |
Effects of zileuton, a new 5-lipoxygenase inhibitor, in experimentally induced colitis in rats.
Topics: Animals; Colitis; Colon; Eicosanoids; Hydroxyurea; Inflammatory Bowel Diseases; Leukocytes; Lipoxygenase Inhibitors; Male; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1993 |
Role of intestinal microflora in chronic inflammation and ulceration of the rat colon.
Topics: Animals; Anti-Bacterial Agents; Colitis; Colon; Colony Count, Microbial; Drug Therapy, Combination; Eicosanoids; Male; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 1994 |
The healing process of chronic colitis in rats, induced by 2,4,6-trinitrobenzene sulfonic acid, with special reference to the role of fibronectin.
Topics: Animals; Blotting, Northern; Chronic Disease; Colitis; Fibronectins; Immunohistochemistry; Male; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 1994 |
[Effect of mesalazine microgranules on experimental colitis].
Topics: Aminosalicylic Acids; Animals; Carrageenan; Colitis; Delayed-Action Preparations; Guinea Pigs; Male; Mesalamine; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1994 |
Neutrophil-independence of the initiation of colonic injury. Comparison of results from three models of experimental colitis in the rat.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Ethanol; Leukocyte Count; Male; Neutropenia; Neutrophils; Peroxidase; Rats; Rats, Sprague-Dawley; Tetradecanoylphorbol Acetate; Time Factors; Trinitrobenzenesulfonic Acid | 1994 |
Protective effect of epidermal growth factor in an experimental model of colitis in rats.
Topics: Animals; Colitis; Disease Models, Animal; Epidermal Growth Factor; Ethanol; Gastric Mucosa; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1994 |
Effect of experimental colitis on bone metabolism in the rat.
Topics: Animals; Body Weight; Bone and Bones; Calcium; Chronic Disease; Colitis; Data Interpretation, Statistical; Male; Organ Size; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1994 |
Mast cells are not essential to inflammation in murine model of colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Haptens; Male; Mast Cells; Mice; Mice, Inbred C57BL; Trinitrobenzenesulfonic Acid | 1994 |
Effect of a new de-N-acetyl-lysoglycosphingolipid on chemically-induced inflammatory bowel disease: possible mechanism of action.
Topics: Animals; Arachidonic Acid; Carbohydrate Sequence; Colitis; Colon; Gangliosides; Humans; Inflammatory Bowel Diseases; Leukotriene B4; Male; Malondialdehyde; Molecular Sequence Data; Organ Size; Pancreas; Peroxidase; Phospholipases A; Phospholipases A2; Platelet Activating Factor; Platelet Aggregation Inhibitors; Rats; Rats, Wistar; Spleen; Synovial Fluid; Trinitrobenzenesulfonic Acid | 1993 |
Involvement of calcitonin gene-related peptide in rat experimental colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Colitis; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1993 |
Role of cytokine-induced neutrophil chemoattractant, a member of the interleukin-8 family, in rat experimental colitis.
Topics: Animals; Chemokines, CXC; Chemotactic Factors; Colitis; Colon; Enzyme-Linked Immunosorbent Assay; Ethanol; Growth Substances; Intercellular Signaling Peptides and Proteins; Interleukin-8; Leukotriene B4; Male; Neutrophils; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1994 |
Beneficial effects of local or systemic lidocaine in experimental colitis.
Topics: Administration, Rectal; Animals; Cell Count; Chemotaxis; Colitis; Colon; Dose-Response Relationship, Drug; Granulocytes; Injections, Subcutaneous; Lidocaine; Male; Mast Cells; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Weight Gain | 1994 |
Experimental colitis in rats induces low-grade endotoxinemia without hepatobiliary abnormalities.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Biliary Tract Diseases; Bilirubin; Colitis; Disease Models, Animal; Endotoxins; Interleukin-6; Liver Diseases; Male; Portal Vein; Rats; Rats, Inbred Lew; Trinitrobenzenesulfonic Acid | 1994 |
Central interleukin-1 receptors contribute to suppression of feeding after acute colitis in the rat.
Topics: Animals; Body Weight; Colitis; Ethanol; Feeding Behavior; Humans; Inflammation; Interleukin-1; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Receptors, Interleukin-1; Recombinant Proteins; Time Factors; Trinitrobenzenesulfonic Acid | 1994 |
Characterization of suppression of food intake following acute colon inflammation in the rat.
Topics: Analysis of Variance; Animals; Appetite; Biomarkers; Colitis; Colon; Ethanol; Feeding Behavior; Gastric Emptying; Inflammation; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 1993 |
Topical capsaicin administration protects against trinitrobenzene sulfonic acid-induced colitis in the rat.
Topics: Administration, Topical; Animals; Capsaicin; Colitis; Diterpenes; In Vitro Techniques; Kinetics; Male; Membranes; Rats; Rats, Sprague-Dawley; Receptors, Drug; Trinitrobenzenesulfonic Acid | 1993 |
Experimental ileitis in dogs and colitis in rats with trinitrobenzene sulfonic acid--colonoscopic and histopathologic studies.
Topics: Animals; Colitis; Colon; Colonoscopy; Dogs; Ethanol; Ileitis; Ileum; Intestinal Mucosa; Male; Rats; Trinitrobenzenesulfonic Acid | 1993 |
Effect of epidermal growth factor on experimental colitis in the rat.
Topics: Aminosalicylic Acids; Animals; Colitis; Colon; Disease Models, Animal; Eicosanoids; Epidermal Growth Factor; Ethanol; Intestinal Mucosa; Male; Mesalamine; Peroxidase; Prednisolone; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1993 |
Defective modulation of colonic secretomotor neurons in a rabbit model of colitis.
Topics: Acetylcholine; Amiloride; Animals; Bucladesine; Colitis; Colon; Dinoprostone; Disease Models, Animal; Epithelium; Inflammation; Male; Membrane Potentials; Motor Neurons; Muscle, Smooth; Rabbits; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 1993 |
Effect of growth hormone on the inflammatory activity of experimental colitis in rats.
Topics: Animals; Biomechanical Phenomena; Colitis; Colon; Growth Hormone; Humans; Insulin-Like Growth Factor I; Male; Peroxidase; Rats; Rats, Wistar; Recombinant Proteins; Trinitrobenzenesulfonic Acid | 1993 |
Defective stimulation of cyclic AMP by prostaglandin E2 in colonic epithelial cells in colitis.
Topics: Animals; Colitis; Colon; Cyclic AMP; Dinoprostone; Epithelium; In Vitro Techniques; Male; Rabbits; Trinitrobenzenesulfonic Acid; Vasoactive Intestinal Peptide | 1993 |
Platelet-activating factor and interleukin 1 are involved in colonic dysmotility in experimental colitis in rats.
Topics: Animals; Colitis; Colon; Cyclooxygenase Inhibitors; Eicosanoids; Gastrointestinal Motility; Interleukin-1; Intestinal Mucosa; Lipoxygenase Inhibitors; Male; Platelet Activating Factor; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 1993 |
On the specificity of altered muscle function in experimental colitis in rats.
Topics: Acetates; Acetic Acid; Animals; Carbachol; Colitis; Colon; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Isometric Contraction; Male; Mice; Mice, Inbred CBA; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Trichinella spiralis; Trichinellosis; Trinitrobenzenesulfonic Acid | 1993 |
Interleukin-2 activity of colonic lamina propria mononuclear cells in a rat model of experimental colitis.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Concanavalin A; Dinoprostone; Disease Models, Animal; Female; Inflammation; Interleukin-2; Intestinal Mucosa; Lymphocyte Activation; Lymphocytes; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values; Spleen; Trinitrobenzenesulfonic Acid | 1993 |
On the suppression of food intake in experimental models of colitis in the rat.
Topics: Acetates; Acetic Acid; Administration, Rectal; Animals; Body Weight; Colitis; Eating; Indoles; Indomethacin; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1993 |
Thromboxanes, indomethacin, and experimental colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Indomethacin; Rats; Thromboxanes; Trinitrobenzenesulfonic Acid | 1993 |
Hapten-induced chronic colitis in the rat: alternatives to trinitrobenzene sulfonic acid.
Topics: Animals; Benzenesulfonates; Colitis; Dinitrochlorobenzene; Disease Models, Animal; Haptens; Male; Neutrophils; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1995 |
The 21-aminosteroid tirilazad mesylate can ameliorate inflammatory bowel disease in rats.
Topics: Animals; Antioxidants; Body Weight; Colitis; Colon; Free Radical Scavengers; Inflammatory Bowel Diseases; Lipid Peroxides; Luminescent Measurements; Male; Organ Size; Peroxidase; Pregnatrienes; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid | 1996 |
Immunosuppressive agents in the treatment of Crohn's disease and ulcerative colitis.
Topics: Animals; Antibodies, Monoclonal; CD4 Antigens; Colitis; Colitis, Ulcerative; Crohn Disease; Humans; Immunosuppressive Agents; Mercaptopurine; Rats; Remission Induction; Trinitrobenzenesulfonic Acid | 1995 |
Therapeutic efficacy of N-3 polyunsaturated fatty acid in experimental Crohn's disease.
Topics: alpha-Linolenic Acid; Animals; Colitis; Colon; Crohn Disease; Fatty Acids, Omega-3; Fish Oils; Food, Formulated; Leukotriene B4; Male; Organ Size; Rats; Rats, Sprague-Dawley; Safflower Oil; Trinitrobenzenesulfonic Acid | 1995 |
Effects of chronic nitric oxide synthase inhibition on TNB-induced colitis in rats.
Topics: Animals; Arginine; Body Weight; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusion Pumps, Implantable; Injections, Subcutaneous; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Molecular association of trinitrobenzenesulfonic acid and surface phospholipids in the development of colitis in rats.
Topics: 1,2-Dipalmitoylphosphatidylcholine; Animals; Chromatography, Thin Layer; Colitis; Colon; Intestinal Mucosa; Male; Phospholipids; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Water | 1996 |
Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis.
Topics: Analysis of Variance; Animals; Chronic Disease; Colitis; Collagen; Collagenases; Colon; Colonic Diseases; Constriction, Pathologic; Dietary Fats, Unsaturated; Disease Models, Animal; Intestinal Obstruction; Male; Phosphatidylcholines; Rats; Rats, Sprague-Dawley; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 1996 |
Tolerance towards resident intestinal flora in mice is abrogated in experimental colitis and restored by treatment with interleukin-10 or antibodies to interleukin-12.
Topics: Animals; Antibodies, Monoclonal; Bacteria; Colitis; Colon; Crohn Disease; Disease Models, Animal; Humans; Immune Tolerance; Immunologic Factors; Interleukin-10; Interleukin-12; Intestine, Small; Intestines; Leukocytes, Mononuclear; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Peyer's Patches; Rats; Recombinant Proteins; Species Specificity; Specific Pathogen-Free Organisms; Spleen; Trinitrobenzenesulfonic Acid | 1996 |
Blocking the CD40L-CD40 interaction in vivo specifically prevents the priming of T helper 1 cells through the inhibition of interleukin 12 secretion.
Topics: Animals; Antibodies; CD40 Ligand; Colitis; Colon; Disease Models, Animal; Female; Interleukin-12; Membrane Glycoproteins; Mice; Mice, Inbred Strains; Protein Binding; Th1 Cells; Trinitrobenzenesulfonic Acid | 1996 |
Toxic dilatation of colon in a rat model of colitis is linked to an inducible form of nitric oxide synthase.
Topics: Animals; Arginine; Colitis; Colon; Dexamethasone; Dilatation; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Guanidines; Hypoxanthines; Inflammation; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Direct evidence of oxidative damage in acute and chronic phases of experimental colitis in rats.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Colon; Ethanol; Glutathione; Intestinal Mucosa; Lipid Peroxidation; Male; Malondialdehyde; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Trinitrobenzenesulfonic Acid | 1996 |
The X-ray contrast medium iodixanol detects increased colonic permeability equally well as 51Cr-labeled ethylenediaminetetraacetic acid in experimental colitis of rats.
Topics: Animals; Cell Membrane Permeability; Chromium Radioisotopes; Colitis; Contrast Media; Edetic Acid; Extravasation of Diagnostic and Therapeutic Materials; Intestinal Absorption; Male; Rats; Rats, Wistar; Triiodobenzoic Acids; Trinitrobenzenesulfonic Acid | 1996 |
Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance.
Topics: Animals; Antibodies; CD28 Antigens; CD3 Complex; CD4-Positive T-Lymphocytes; Colitis; Cytokines; Female; Granulomatous Disease, Chronic; Haptens; Humans; Immune Tolerance; Immunotherapy, Adoptive; Interleukin-10; Interleukin-4; Intestinal Mucosa; Mice; Mice, Inbred Strains; Ovalbumin; Peyer's Patches; T-Lymphocytes; Th1 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 1996 |
[Immunohistochemistry of inducible nitric oxide synthase in rat with trinitrobenzene sulfonic acid induced colitis].
Topics: Animals; Colitis; Disease Models, Animal; Female; Immunohistochemistry; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
Role of histamine in a rat model of colitis.
Topics: Animals; Colitis; Diphenhydramine; Ethanol; Female; Histamine; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1995 |
Bacterial peptides enhance inflammatory activity in a rat model of colitis.
Topics: Animals; Colitis; Dinoprostone; Disease Models, Animal; Eicosanoids; Intestinal Mucosa; Leukotriene B4; Male; N-Formylmethionine Leucyl-Phenylalanine; Peroxidase; Rats; Rats, Sprague-Dawley; Thromboxane B2; Trinitrobenzenesulfonic Acid | 1996 |
Dissociation of temperature changes and anorexia after experimental colitis and LPS administration in rats.
Topics: Animals; Anorexia; Body Temperature; Body Weight; Colitis; Eating; Feeding Behavior; Lipopolysaccharides; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Impairment of antioxidants in colonic epithelial cells isolated from trinitrobenzene sulphonic acid-induced colitis rats. Protective effect of rebamipide.
Topics: Alanine; Analysis of Variance; Animals; Anti-Ulcer Agents; Antioxidants; Colitis; Culture Techniques; Disease Models, Animal; Glutathione; Glutathione Peroxidase; Glutathione Transferase; Intestinal Mucosa; Male; Quinolones; Random Allocation; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
Colitis causes bone loss in rats through suppression of bone formation.
Topics: Animals; Bone Development; Bone Resorption; Colitis; Female; Inflammatory Bowel Diseases; Male; Osteoporosis; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1996 |
Application of natural products in experimental models of intestinal inflammation in rats.
Topics: Acetic Acid; Alkaline Phosphatase; Animals; Biomarkers; Colitis; Disease Models, Animal; Humans; Inflammatory Bowel Diseases; Leukotriene B4; Peroxidase; Quercetin; Rats; Rutin; Trinitrobenzenesulfonic Acid | 1996 |
Down-regulation of substance P receptors during colitis induced by trinitrobenzene sulfonic acid in rats.
Topics: Animals; Colitis; Disease Models, Animal; Down-Regulation; Haptens; Humans; Indoles; Inflammatory Bowel Diseases; Isoindoles; Male; Rats; Rats, Sprague-Dawley; Receptors, Neurokinin-1; Trinitrobenzenesulfonic Acid | 1996 |
Previous inflammation alters the response of the rat colon to stress.
Topics: Animals; Colitis; Colon; Corticosterone; Interleukin-1; Male; Norepinephrine; Peroxidase; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; Stress, Physiological; Trinitrobenzenesulfonic Acid | 1996 |
Histomorphometric evaluation of experimentally induced colitis with trinitrobenzene-sulphonic acid in rats.
Topics: Acute Disease; Animals; Colitis; Colon; Disease Progression; Fibrosis; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Necrosis; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 1996 |
Nucleoside-nucleotide free diet protects rat colonic mucosa from damage induced by trinitrobenzene sulphonic acid.
Topics: Animals; Body Weight; Colitis; Colon; Diet; Female; Intestinal Mucosa; Nucleosides; Nucleotides; Organ Size; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Effect of IL-12 and antibodies to IL-12 on established granulomatous colitis in mice.
Topics: Animals; Colitis; Granuloma; Immunologic Techniques; Interleukin-12; Mice; Mice, Inbred BALB C; Trinitrobenzenesulfonic Acid | 1996 |
The mechanism of altered neural function in a rat model of acute colitis.
Topics: Acute Disease; Administration, Topical; Adrenergic Fibers; Animals; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Glucocorticoids; Interleukin 1 Receptor Antagonist Protein; Male; Mice; Norepinephrine; Potassium Chloride; Pregnenediones; Premedication; Rats; Rats, Nude; Rats, Sprague-Dawley; Receptors, Interleukin-1; Sialoglycoproteins; Trinitrobenzenesulfonic Acid | 1997 |
Intracolonic administration of zileuton, a selective 5-lipoxygenase inhibitor, accelerates healing in a rat model of chronic colitis.
Topics: Aminosalicylic Acids; Animals; Anti-Inflammatory Agents, Non-Steroidal; Chronic Disease; Colitis; Colon; Eicosanoids; Female; Hydroxyurea; Lipoxygenase Inhibitors; Mesalamine; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1996 |
Incrimination of anaerobic bacteria in the induction of experimental colitis.
Topics: Animals; Bacteria, Anaerobic; Bacterial Infections; Colitis; Colon; Dinoprostone; Ethanol; Male; Necrosis; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1997 |
Stress-induced enhancement of colitis in rats: CRF and arginine vasopressin are not involved.
Topics: Animals; Arginine Vasopressin; Colitis; Colon; Corticotropin-Releasing Hormone; Hormone Antagonists; Injections, Intraventricular; Intestinal Mucosa; Male; Peptide Fragments; Peroxidase; Rats; Rats, Wistar; Restraint, Physical; Stress, Physiological; Trinitrobenzenesulfonic Acid | 1997 |
Effects of chemical sympathectomy and sensory nerve ablation on experimental colitis in the rat.
Topics: Administration, Topical; Animals; Capsaicin; Colitis; Colon; Denervation; Female; Injections; Lidocaine; Male; Nervous System; Oxidopamine; Rats; Rats, Sprague-Dawley; Sensation; Sympathectomy, Chemical; Trinitrobenzenesulfonic Acid | 1997 |
Anti-inflammatory properties of interleukin-10 administration in hapten-induced colitis.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Female; Gene Expression; Interleukin-10; Leukocyte Count; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Up-Regulation | 1997 |
Effect of acute pentoxifylline treatment in an experimental model of colitis.
Topics: Animals; Colitis; Collagen; Colon; Disease Models, Animal; Male; Pentoxifylline; Phosphodiesterase Inhibitors; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1997 |
Role of cytokines in experimental colitis: relation to intestinal permeability.
Topics: Acute-Phase Proteins; Animals; Colitis; Colon; Coloring Agents; Cytokines; Disease Models, Animal; Evans Blue; Follow-Up Studies; Immunohistochemistry; Interleukin 1 Receptor Antagonist Protein; Macrophages; Male; Microscopy, Fluorescence; Permeability; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Sialoglycoproteins; Trinitrobenzenesulfonic Acid | 1997 |
Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.
Topics: Animals; Antibodies; Chronic Disease; Colitis; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Mice; Mice, Inbred Strains; Mice, Knockout; Mice, Transgenic; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1997 |
Nucleoside-nucleotide-free diet suppresses cytokine production and contact sensitivity responses in rats with trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Colitis; Colon; Cytokines; Dermatitis, Contact; Diet; Ear, External; Female; Interleukin-8; Nucleosides; Nucleotides; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1997 |
Increased expression of transforming growth factor alpha precursors in acute experimental colitis in rats.
Topics: Acute Disease; Animals; Blotting, Northern; Blotting, Western; Colitis; DNA Primers; Epidermal Growth Factor; Ethanol; Gene Expression Regulation; Immunohistochemistry; Male; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Transforming Growth Factor alpha; Trinitrobenzenesulfonic Acid | 1997 |
Hepatocyte tight-junctional permeability is increased in rat experimental colitis.
Topics: Animals; Antibodies, Monoclonal; Bile; Bile Canaliculi; Colitis; Colon; Fluorescent Antibody Technique, Indirect; Horseradish Peroxidase; Intestinal Mucosa; Lanthanum; Liver; Liver Function Tests; Male; Membrane Proteins; Microscopy, Electron; Organ Size; Rats; Rats, Sprague-Dawley; Reference Values; Spleen; Tight Junctions; Trinitrobenzenesulfonic Acid; Weight Gain | 1997 |
Excess glutamine exacerbates trinitrobenzenesulfonic acid-induced colitis in rats.
Topics: Animals; Colitis; Colon; Crohn Disease; Female; Food, Formulated; Glutamine; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 1997 |
Scintigraphic evaluation of experimental colitis in rabbits.
Topics: Animals; Colitis; Colon; Female; Humans; Immunoglobulin G; Indium Radioisotopes; Leukocytes; Liposomes; Polyethylene Glycols; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution; Trinitrobenzenesulfonic Acid | 1997 |
Effect of Z-103 on TNB-induced colitis in rats.
Topics: Animals; Anti-Ulcer Agents; Antioxidants; Carnosine; Colitis; Colon; Intestinal Mucosa; Male; Organometallic Compounds; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid; Zinc; Zinc Compounds; Zinc Sulfate | 1997 |
Effects of a thromboxane A2 receptor antagonist in an animal model of inflammatory bowel disease.
Topics: Animals; Bridged Bicyclo Compounds; Colitis; Colon; Dose-Response Relationship, Drug; Ethanol; Fatty Acids, Monounsaturated; Leukotriene B4; Male; Rats; Rats, Wistar; Receptors, Thromboxane; Thromboxane A2; Trinitrobenzenesulfonic Acid | 1997 |
Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats.
Topics: Animals; Colitis; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid | 1997 |
Prophylactic effect of dietary glutamine supplementation on interleukin 8 and tumour necrosis factor alpha production in trinitrobenzene sulphonic acid induced colitis.
Topics: Analysis of Variance; Animals; Body Weight; Colitis; Colon; Diet; Disease Models, Animal; Drug Administration Schedule; Female; Glutamine; Interleukin-8; Intestinal Mucosa; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1997 |
Intracolonic release of nitric oxide during trinitrobenzene sulfonic acid rat colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Leukotriene B4; Male; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1997 |
Disruption of intestinal barrier function associated with experimental colitis: possible role of mast cells.
Topics: Animals; Biomarkers; Body Water; Chromium Radioisotopes; Chymases; Colitis; Colon; Dexamethasone; Disease Models, Animal; Edetic Acid; Granulocytes; Intestinal Absorption; Male; Mast Cells; Peroxidase; Rats; Rats, Sprague-Dawley; Serine Endopeptidases; Thioxanthenes; Trinitrobenzenesulfonic Acid; Xanthones | 1998 |
Beneficial effect of ursodeoxycholic acid on mucosal damage in trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Body Weight; Colitis; Intestinal Mucosa; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid; Ursodeoxycholic Acid | 1997 |
Effect of methylprednisolone on the ulceration, matrix metalloproteinase distribution and eicosanoid production in a model of colitis in the rabbit.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Anti-Inflammatory Agents; Colitis; Colon; Dinoprostone; Disease Models, Animal; Eicosanoids; Leukocyte Count; Leukotriene B4; Metalloendopeptidases; Methylprednisolone; Neutrophils; Rabbits; Random Allocation; Trinitrobenzenesulfonic Acid | 1997 |
Effect of mizolastine on visceral sensory afferent sensitivity and inflammation during experimental colitis.
Topics: Animals; Benzimidazoles; Colitis; Colon; Histamine H1 Antagonists; Hypersensitivity; In Vitro Techniques; Male; Neurons, Afferent; Organ Size; Peroxidase; Rats; Rats, Wistar; Terfenadine; Trinitrobenzenesulfonic Acid | 1998 |
Effect of intracolonic benzalkonium chloride on trinitrobenzene sulphonic acid-induced colitis in the rat.
Topics: Animals; Anti-Infective Agents, Local; Benzalkonium Compounds; CD4 Antigens; CD4-Positive T-Lymphocytes; CD8 Antigens; CD8-Positive T-Lymphocytes; Colitis; Colon; Immunohistochemistry; Intestinal Mucosa; Macrophages; Male; Peroxidase; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Weight Gain; Weight Loss | 1998 |
The effect of heparin on trinitrobenzene sulphonic acid-induced colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents; Anticoagulants; Blood Platelets; Colitis; Colon; Dexamethasone; Erythrocyte Count; Heparin; Male; Microradiography; Partial Thromboplastin Time; Peroxidase; Rats; Rats, Sprague-Dawley; Treatment Outcome; Trinitrobenzenesulfonic Acid | 1998 |
CD4+ T cells from 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis rodents migrate to the recipient's colon upon transfer; down-regulation by CD8+ T cells.
Topics: Adoptive Transfer; Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Colitis; Colon; Dinitrofluorobenzene; Down-Regulation; Immunohistochemistry; Interferon-gamma; Interleukin-2; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Polymerase Chain Reaction; Rats; Trinitrobenzenesulfonic Acid | 1998 |
CD45RChighCD4+ intestinal mucosal lymphocytes infiltrating in the inflamed colonic mucosa of a novel rat colitis model induced by TNB immunization.
Topics: Animals; Antibodies, Monoclonal; Base Sequence; CD4 Antigens; CD4-Positive T-Lymphocytes; Colitis; Colon; Crohn Disease; Cytokines; Disease Models, Animal; DNA Primers; Female; Gene Expression; Humans; Immunization; Intestinal Mucosa; Leukocyte Common Antigens; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 1998 |
Curative treatment of an experimentally induced colitis by a CD44 variant V7-specific antibody.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Colitis; Cytokines; Hyaluronan Receptors; Inflammatory Bowel Diseases; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Th1 Cells; Trinitrobenzenesulfonic Acid | 1998 |
Effects of morin on an experimental model of acute colitis in rats.
Topics: Acute Disease; Administration, Oral; Animals; Antioxidants; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Flavonoids; Leukotriene B4; Malondialdehyde; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1998 |
Influence of trimebutine on inflammation- and stress-induced hyperalgesia to rectal distension in rats.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Gastrointestinal Agents; Hyperalgesia; Male; Peritoneal Cavity; Proctitis; Rats; Rats, Wistar; Receptors, Opioid; Rectum; Restraint, Physical; Trimebutine; Trinitrobenzenesulfonic Acid | 1998 |
5-ASA-glutamate protects rats from inflammatory bowel disease induced by intracolonic administration of trinitrobenzensulfonic acid.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Colitis; Colon; Disease Models, Animal; Eicosanoids; Glutamates; Leukotrienes; Prostaglandins; Radioimmunoassay; Random Allocation; Rats; Rats, Sprague-Dawley; Statistics, Nonparametric; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1998 |
Protective role of vagal afferents in experimentally-induced colitis in rats.
Topics: Animals; Autonomic Nervous System; Capsaicin; Colitis; Colon; Denervation; Intestinal Absorption; Intestinal Mucosa; Male; Neurons, Afferent; Neutrophils; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Vagus Nerve | 1998 |
Colitis-induced changes in the level of trace elements in rat colon and other tissues.
Topics: Acetic Acid; Animals; Colitis; Colon; Copper; Glutathione Peroxidase; Liver; Male; Manganese; Peroxidase; Rats; Rats, Sprague-Dawley; Selenium; Trace Elements; Trinitrobenzenesulfonic Acid; Zinc | 1998 |
Elevated plasma leptin concentrations in early stages of experimental intestinal inflammation in rats.
Topics: Animals; Body Weight; Colitis; Eating; Ileitis; Leptin; Male; Proteins; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1998 |
Role of nitric oxide in inflammation-induced suppression of secretion in a mouse model of acute colitis.
Topics: Acute Disease; Animals; Biological Transport; Colitis; Colon; Electrolytes; Enzyme Inhibitors; Lysine; Male; Mice; Mice, Inbred C57BL; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; RNA, Messenger; Trinitrobenzenesulfonic Acid | 1998 |
Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Body Weight; Colitis; Enzyme Inhibitors; Free Radical Scavengers; Guanidines; Immunohistochemistry; Male; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tyrosine | 1998 |
Protective effect of taurine on TNBS-induced inflammatory bowel disease in rats.
Topics: Animals; Colitis; Colon; Dinoprostone; Eicosanoids; Inflammatory Bowel Diseases; Luminescent Measurements; Male; Peroxidase; Rats; Rats, Sprague-Dawley; Taurine; Trinitrobenzenesulfonic Acid | 1998 |
The role of luminal bacteria in colitis: more than an antigenic drive.
Topics: Animals; Colitis; Gastrointestinal Contents; Picrates; Rats; Trinitrobenzenesulfonic Acid | 1998 |
Effect of chronic nicotine administration on trinitrobenzene sulphonic acid-induced colitis.
Topics: Animals; Colitis; Colon; Dinoprostone; Dose-Response Relationship, Drug; Interleukin-1; Intestinal Mucosa; Leukotriene B4; Male; Nicotine; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 1998 |
Blockade of Poly(ADP-ribose) synthetase inhibits neutrophil recruitment, oxidant generation, and mucosal injury in murine colitis.
Topics: Animals; Colitis; Disease Models, Animal; Immunohistochemistry; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Malondialdehyde; Mice; Neutrophils; Oxidative Stress; Permeability; Peroxidase; Poly(ADP-ribose) Polymerase Inhibitors; Severity of Illness Index; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine; Up-Regulation | 1999 |
Experimental colitis increases small intestine permeability in the rat.
Topics: Animals; Cell Membrane Permeability; Colitis; Intestinal Absorption; Intestine, Small; Male; Membrane Proteins; Occludin; Rats; Rats, Sprague-Dawley; Tight Junctions; Trinitrobenzenesulfonic Acid | 1999 |
SR140333, a substance P receptor antagonist, influences morphological and motor changes in rat experimental colitis.
Topics: Animals; Colitis; Colon; Inflammation; Male; Muscle Contraction; Muscle, Smooth; Neurokinin-1 Receptor Antagonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Substance P; Trinitrobenzenesulfonic Acid | 1999 |
Effects of kappa opioids in the inflamed rat colon.
Topics: Acetamides; Action Potentials; Analgesics, Opioid; Animals; Benzamides; Chronic Disease; Colitis; Colon; Electrophysiology; Male; Morphine; Naloxone; Narcotic Antagonists; Nerve Fibers; Neurons, Afferent; Pain Measurement; Piperazines; Pressure; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa; Rectum; Trinitrobenzenesulfonic Acid | 1999 |
Protein kinase C mediates experimental colitis in the rat.
Topics: Animals; Colitis; Colon; Enzyme Inhibitors; Ethanol; Indoles; Intestinal Mucosa; Isoenzymes; Male; Maleimides; Neutropenia; Peroxidase; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Tetradecanoylphorbol Acetate; Trinitrobenzenesulfonic Acid | 1999 |
Altered myoelectrical activity in noninflamed ileum of rats with colitis induced by trinitrobenzene sulphonic acid.
Topics: Animals; Atropine; Colitis; Colon; Electromyography; Enzyme Inhibitors; Ileum; Indomethacin; Male; Myoelectric Complex, Migrating; NG-Nitroarginine Methyl Ester; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
VCAM-1 and ICAM-1 mediate leukocyte-endothelial cell adhesion in rat experimental colitis.
Topics: Animals; Antibodies, Monoclonal; Cell Adhesion; Colitis; Endothelium, Vascular; Intercellular Adhesion Molecule-1; Leukocytes; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1 | 1999 |
Susceptibility of Lewis and Fischer rats to stress-induced worsening of TNB-colitis: protective role of brain CRF.
Topics: Animals; Cerebral Ventricles; Colitis; Colon; Corticosterone; Corticotropin-Releasing Hormone; Female; Genetic Predisposition to Disease; Injections, Intraventricular; Intestinal Mucosa; Neuroprotective Agents; Peptide Fragments; Peroxidase; Rats; Rats, Inbred F344; Rats, Inbred Lew; Species Specificity; Stress, Psychological; Trinitrobenzenesulfonic Acid | 1999 |
Induction of iNOS in a rat model of acute colitis.
Topics: Acute Disease; Animals; Colitis; Disease Models, Animal; Enzyme Induction; Humans; Male; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Morphological and functional changes in the colonic epithelial cells in a rabbit model of colitis.
Topics: Animals; Binding Sites; Colitis; Colon; Dinoprostone; Disease Models, Animal; Epithelial Cells; Intestinal Mucosa; Ion Transport; Microscopy, Electron; Rabbits; Sodium Radioisotopes; Trinitrobenzenesulfonic Acid | 1999 |
Behavioral evaluation of visceral pain in a rat model of colonic inflammation.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Benzofurans; Cognition; Colitis; Colon; Discrimination, Psychological; Male; Morphine; Pain; Pyrrolidines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Viscera | 1999 |
Lack of beneficial effect of COX-2 inhibitors in an experimental model of colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Isoenzymes; Male; Nitrobenzenes; Peroxidase; Peroxidases; Phenols; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Sprague-Dawley; Sulfonamides; Thiazoles; Trinitrobenzenesulfonic Acid | 1999 |
Experimental colitis increases blood-brain barrier permeability in rabbits.
Topics: Acetic Acid; Animals; Blood Pressure; Blood-Brain Barrier; Brain; Capillary Permeability; Cerebrovascular Circulation; Colitis; Dextrans; Fluorescein; Fluorescein-5-isothiocyanate; Male; Microspheres; Rabbits; Trinitrobenzenesulfonic Acid; Vascular Resistance | 1999 |
Colon-specific delivery of budesonide with azopolymer-coated pellets: therapeutic effects of budesonide with a novel dosage form against 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents; Budesonide; Colitis; Colon; Drug Implants; Enema; Male; Polymers; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Temporal distribution of neuronal and inducible nitric oxide synthase and nitrotyrosine during colitis in rats.
Topics: Animals; Colitis; Immunohistochemistry; Male; Neurons; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Time Factors; Trinitrobenzenesulfonic Acid; Tyrosine | 1999 |
Intestinal inflammation in adhesion molecule-deficient mice: an assessment of P-selectin alone and in combination with ICAM-1 or E-selectin.
Topics: Acetates; Animals; Colitis; Colon; Disease Models, Animal; E-Selectin; Gene Expression; Intercellular Adhesion Molecule-1; Intestines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; P-Selectin; Trinitrobenzenesulfonic Acid | 1999 |
Effect of DA-6034, a derivative of flavonoid, on experimental animal models of inflammatory bowel disease.
Topics: Acetic Acid; Animals; Animals, Genetically Modified; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; beta 2-Microglobulin; Colitis; Flavonoids; Gastrointestinal Agents; HLA-B27 Antigen; Humans; Inflammatory Bowel Diseases; Organ Size; Prednisolone; Rats; Sulfasalazine; Trinitrobenzenesulfonic Acid; Weight Loss | 1999 |
Inflammatory neutrophils secrete annexin 1 during experimentally induced colitis in rats.
Topics: Animals; Annexin A1; Colitis; Immunoblotting; Immunoenzyme Techniques; Intestinal Mucosa; Macrophages; Neutrophils; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Protection of trinitrobenzene sulfonic acid-induced colitis by an interleukin 2-IgG2b fusion protein in mice.
Topics: Animals; Colitis; Colon; Female; Immunoglobulin G; Interleukin-2; Mice; Mice, Inbred BALB C; Recombinant Fusion Proteins; Trinitrobenzenesulfonic Acid | 1999 |
Progressive alterations in circular smooth muscle contractility in TNBS-induced colitis in rats.
Topics: Acetylcholine; Animals; Atropine; Colitis; Dose-Response Relationship, Drug; Gastrointestinal Motility; Hexamethonium; Male; Muscle Contraction; Muscle, Smooth; Neurokinin A; Nicotinic Antagonists; Parasympatholytics; Potassium Chloride; Rats; Rats, Sprague-Dawley; Substance P; Tetrodotoxin; Trinitrobenzenesulfonic Acid; Vasodilator Agents | 1999 |
Beneficial effects of ropivacaine in rat experimental colitis.
Topics: Acetylcholine; Amides; Anesthetics, Local; Animals; Budesonide; Colitis; Ethanol; Gastrointestinal Motility; In Vitro Techniques; Male; Mesalamine; Mucous Membrane; Peroxidase; Rats; Rats, Sprague-Dawley; Ropivacaine; Time Factors; Trinitrobenzenesulfonic Acid; Wound Healing | 1999 |
Effect of dehydroleucodine in experimental colitis in rats and mice.
Topics: Acetic Acid; Animals; Anti-Ulcer Agents; Colitis; Colon; Diarrhea; Irritants; Lactones; Male; Mice; Organ Size; Rats; Rats, Wistar; Sesquiterpenes; Trinitrobenzenesulfonic Acid | 1999 |
The effect of Oren-gedoku-to on experimental colitis in rats.
Topics: Animals; Anti-Ulcer Agents; Body Weight; Colitis; Drugs, Chinese Herbal; Gastrointestinal Agents; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1999 |
Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice.
Topics: Animals; Antibodies; Apoptosis; Colitis; fas Receptor; Interferon-gamma; Interleukin-12; Male; Mice; Mice, Inbred MRL lpr; Mice, Inbred Strains; T-Lymphocytes; Th1 Cells; Trinitrobenzenesulfonic Acid | 1999 |
Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice.
Topics: Acute Disease; Animals; Chronic Disease; Colitis; Female; Fluorescent Antibody Technique; Gene Expression; Male; Mice; Mice, Mutant Strains; Neutrophils; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 1999 |
Altered expression of the Na+/H+ exchanger isoform-3 in experimental colitis: effect of garlic.
Topics: Animals; Base Sequence; Blotting, Western; Body Water; Colitis; Colon; DNA Primers; Enzyme Induction; Garlic; Gene Expression; Ileum; Male; Peroxidase; Plants, Medicinal; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Trinitrobenzenesulfonic Acid | 1999 |
The effect of an inhibitor of matrix metalloproteinases on colonic inflammation in a trinitrobenzenesulphonic acid rat model of inflammatory bowel disease.
Topics: Animals; Biological Availability; Colitis; Hydroxamic Acids; Inflammatory Bowel Diseases; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peroxidase; Protease Inhibitors; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 1999 |
Desulfonation of a colitis inducer 2,4,6-trinitrobenzene sulfonic acid produces sulfite radical.
Topics: Animals; Colitis; Colon; Electron Spin Resonance Spectroscopy; Erythrocytes; Free Radicals; Male; Rats; Rats, Sprague-Dawley; Sulfites; Sulfones; Trinitrobenzenesulfonic Acid | 1999 |
Anti-inflammatory activity of diosmin and hesperidin in rat colitis induced by TNBS.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Diosmin; Female; Hesperidin; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Validation of a pharmacokinetic model of colon-specific drug delivery and the therapeutic effects of chitosan capsules containing 5-aminosalicylic acid on 2,4,6-trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Capsules; Chitin; Chitosan; Colitis; Colon; Disease Models, Animal; Drug Carriers; Male; Mesalamine; Models, Biological; Rats; Rats, Wistar; Reproducibility of Results; Sulfasalazine; Trinitrobenzenesulfonic Acid | 1999 |
Aminoguanidine has both an anti-inflammatory effect on experimental colitis and a proliferative effect on colonic mucosal cells.
Topics: Analysis of Variance; Animals; Colitis; Enzyme Inhibitors; Epithelial Cells; Guanidines; Intestinal Mucosa; Male; Nitric Oxide Synthase; Nitrogen Oxides; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Vagally dependent protective action of calcitonin gene-related peptide on colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Injections, Intraventricular; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Vagotomy | 1999 |
Experimental colitis induced by trinitrobenzenesulfonic acid: an ultrastructural and histochemical study.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Goblet Cells; Male; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1999 |
Effects of spinal cholecystokinin receptor antagonists on morphine antinociception in a model of visceral pain in the rat.
Topics: Analgesics; Anesthesia; Animals; Benzodiazepinones; Colitis; Colon; Devazepide; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Male; Morphine; Phenylurea Compounds; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Rectum; Spinal Cord; Time Factors; Trinitrobenzenesulfonic Acid; Viscera | 2000 |
Therapeutic role for bismuth compounds in TNBS-induced colitis in the rat.
Topics: Animals; Anti-Ulcer Agents; Bismuth; Colitis; Female; Mesalamine; Organometallic Compounds; Rats; Rats, Sprague-Dawley; Salicylates; Trinitrobenzenesulfonic Acid | 2000 |
Oral tolerance therapy in an experimental model of colitis.
Topics: Administration, Oral; Animals; Antigens; Colitis; Colon; Cytokines; Desensitization, Immunologic; Humans; Immune Tolerance; Proteins; Rats; T-Lymphocytes; Tissue Extracts; Trinitrobenzenesulfonic Acid | 2000 |
Treatment of experimental colitis by oral tolerance induction: a central role for suppressor lymphocytes.
Topics: Administration, Oral; Adoptive Transfer; Animals; Colitis; Desensitization, Immunologic; Down-Regulation; Immune Tolerance; Male; Proteins; Rats; Rats, Inbred Strains; T-Lymphocytes, Regulatory; Th2 Cells; Tissue Extracts; Trinitrobenzenesulfonic Acid | 2000 |
Growth failure occurs through a decrease in insulin-like growth factor 1 which is independent of undernutrition in a rat model of colitis.
Topics: Animals; Colitis; Dietary Supplements; Female; Growth Disorders; Insulin-Like Growth Factor I; Interleukin-6; Male; Nutrition Disorders; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Weight Gain | 2000 |
Alterations in protein kinase C isoforms in experimentally-induced colitis in the rat.
Topics: Animals; Animals, Genetically Modified; Cell Membrane; Colitis; Colon; Cytosol; HLA-B27 Antigen; Intestinal Mucosa; Isoenzymes; Male; Protein Kinase C; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2000 |
Recombinant factor XIII improves established experimental colitis in rats.
Topics: Animals; Colitis; Factor XIII; Humans; Intestinal Mucosa; Male; Rats; Rats, Wistar; Recombinant Proteins; Transglutaminases; Trinitrobenzenesulfonic Acid; Wound Healing | 2000 |
Effect of intrarectal prostaglandin E2 analogue (enprostil) on trinitrobenzenesulphonic acid-induced colitis in rats.
Topics: Animals; Colitis; Colon; Eicosanoids; Enprostil; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2000 |
Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice.
Topics: Animals; Colitis; Haptens; Inflammation; Interferon-gamma; Mice; Mice, Inbred C57BL; Mice, Knockout; Th1 Cells; Trinitrobenzenesulfonic Acid | 2000 |
Replenishment of glutathione levels improves mucosal function in experimental acute colitis.
Topics: Acetylcysteine; Acute Disease; Animals; Colitis; Ethanol; Glutathione; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Time Factors; Trinitrobenzenesulfonic Acid | 2000 |
Effects of trimetazidine on oxidant/antioxidant status in trinitrobenzenesulfonic acid-induced chronic colitis.
Topics: Administration, Rectal; Animals; Chronic Disease; Colitis; Ethanol; Glutathione; Injections, Intraperitoneal; Lipid Peroxidation; Male; Malondialdehyde; Peroxidase; Rats; Rats, Sprague-Dawley; Solvents; Trimetazidine; Trinitrobenzenesulfonic Acid; Vasodilator Agents | 2000 |
Disturbed bile secretion and cytochrome P450 function during the acute state of experimental colitis in rats.
Topics: Animals; Bile; Colitis; Cytochrome P-450 Enzyme System; Disease Models, Animal; Liver; Male; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Proto-Oncogene Proteins c-rel; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2000 |
Enhancement of immune tolerance via induction of NK1.1 positive liver-associated-lymphocytes under immunosuppressive conditions.
Topics: Animals; Antigens; Antigens, Ly; Antigens, Surface; Colitis; Immune Tolerance; Immunosuppression Therapy; Immunosuppressive Agents; Lectins, C-Type; Liver; Lymphocyte Subsets; Male; Mice; Mice, Inbred C57BL; NK Cell Lectin-Like Receptor Subfamily B; Proteins; Tacrolimus; Trinitrobenzenesulfonic Acid | 2000 |
Abrogation of experimental colitis correlates with increased apoptosis in mice deficient for CD44 variant exon 7 (CD44v7).
Topics: Adoptive Transfer; Animals; Apoptosis; Bone Marrow Transplantation; CD40 Antigens; Colitis; Colon; Exons; Hyaluronan Receptors; Inflammatory Bowel Diseases; Interleukin-10; Intestinal Mucosa; Mice; Mice, Knockout; Protein Isoforms; Radiation Chimera; Trinitrobenzenesulfonic Acid | 2000 |
A novel receptor for calcitonin gene-related peptide (CGRP) mediates secretion in the rat colon: implications for secretory function in colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Colitis; Colon; Electric Conductivity; Humans; Ion Transport; Male; Rats; Rats, Wistar; Receptors, Calcitonin Gene-Related Peptide; Tetrodotoxin; Trinitrobenzenesulfonic Acid | 2000 |
Treatment of experimental (Trinitrobenzene sulfonic acid) colitis by intranasal administration of transforming growth factor (TGF)-beta1 plasmid: TGF-beta1-mediated suppression of T helper cell type 1 response occurs by interleukin (IL)-10 induction and I
Topics: Administration, Intranasal; Animals; Colitis; Colon; Cytokines; Cytomegalovirus; Genetic Therapy; Injections, Intraperitoneal; Intestinal Mucosa; Male; Mice; Mice, Inbred Strains; Plasmids; Recombinant Proteins; Swine; Th1 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2000 |
Experimental inflammatory bowel disease--role of T cells.
Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Transplantation; Colitis; Dose-Response Relationship, Drug; Genetic Predisposition to Disease; Lymph Nodes; Lymphocyte Subsets; Male; Mesentery; Mice; Mice, Inbred Strains; Species Specificity; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2000 |
Protective role of neurotrophins in experimental inflammation of the rat gut.
Topics: Animals; Antibodies; Calcitonin Gene-Related Peptide; Colitis; Colon; Gene Expression; Male; Nerve Growth Factor; Neurotrophin 3; Neutralization Tests; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptor, trkA; Receptor, trkC; RNA, Messenger; Substance P; Tachykinins; Trinitrobenzenesulfonic Acid | 2000 |
The effect of berberine chloride on experimental colitis in rats in vivo and in vitro.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Berberine; Cells, Cultured; Colitis; Colon; Interleukin-8; Intestinal Mucosa; Leukocytes, Mononuclear; Male; Organ Size; Peroxidase; Rats; Rats, Sprague-Dawley; Rectum; Trinitrobenzenesulfonic Acid | 2000 |
Dose-dependent effects of recombinant human interleukin-11 on contractile properties in rabbit 2,4,6-trinitrobenzene sulfonic acid colitis.
Topics: Acetylcholine; Animals; Colitis; Colon; Dinoprostone; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Interleukin-11; Male; Motilin; Muscle Contraction; Muscle, Smooth; Potassium Chloride; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Neurokinin-1; Receptors, Neuropeptide; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; Substance P; Tensile Strength; Trinitrobenzenesulfonic Acid | 2000 |
Intestinal anti-inflammatory activity of UR-12746, a novel 5-ASA conjugate, on acute and chronic experimental colitis in the rat.
Topics: Acute Disease; Aminosalicylic Acids; Animals; Anti-Inflammatory Agents; Aza Compounds; Chronic Disease; Colitis; Colon; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Gastrointestinal Agents; Intestinal Mucosa; Intestines; Male; Mesalamine; Platelet Activating Factor; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid | 2000 |
Mice deficient in Th1- and Th2-type cytokines develop distinct forms of hapten-induced colitis.
Topics: Animals; Antibodies; Antibody Specificity; Atrophy; Colitis; Colon; Cytokines; Disease Susceptibility; Enema; Interferon-gamma; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2000 |
Oral administration of inducible nitric oxide synthase inhibitors reduces nitric oxide synthesis but has no effect on the severity of experimental colitis.
Topics: Administration, Oral; Animals; Colitis; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Intestinal Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Reference Values; Severity of Illness Index; Statistics, Nonparametric; Trinitrobenzenesulfonic Acid | 2000 |
The effect of alpha-melanocyte stimulating hormone on colonic inflammation in the rat.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Colitis; Cyclooxygenase 1; Female; Free Radical Scavengers; Indomethacin; Isoenzymes; Male; Membrane Proteins; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Signal Transduction; Sulfonamides; Trinitrobenzenesulfonic Acid | 2000 |
Evaluation of oxidative stress in experimental colitis: effects of L-arginine-nitric oxide pathway manipulation.
Topics: Analysis of Variance; Animals; Arginine; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Glutathione; Glutathione Peroxidase; Lipid Peroxidation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid | 2000 |
Interleukin 16 is up-regulated in Crohn's disease and participates in TNBS colitis in mice.
Topics: Animals; Antibodies, Monoclonal; Colitis; Colon; Crohn Disease; Disease Models, Animal; Gene Expression Regulation; Humans; Interleukin-16; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transcription, Genetic; Trinitrobenzenesulfonic Acid | 2000 |
Adrenal cortical activation in murine colitis.
Topics: Adrenal Cortex; Adrenal Glands; Animals; Antibodies, Monoclonal; Colitis; Corticosterone; Disease Susceptibility; Drug Resistance; Interleukin-6; Male; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Microscopy, Electron; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured | 2000 |
The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.
Topics: Acute Disease; Administration, Rectal; Animals; Cell Movement; Chemokine CCL5; Chronic Disease; Colitis; Disease Progression; Dose-Response Relationship, Drug; Haptens; Inflammation Mediators; Injections, Intravenous; Leukocyte Count; Male; Mast Cells; Monocytes; Rats; Rats, Wistar; Receptors, CCR1; Receptors, CCR5; Receptors, Chemokine; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid | 2001 |
Treatment with fluoride or bisphosphonates prevents bone loss associated with colitis in the rat.
Topics: Animals; Anti-Inflammatory Agents; Colitis; Diphosphonates; Disease Models, Animal; Inflammatory Bowel Diseases; Intestine, Large; Male; Osteoporosis; Pamidronate; Rats; Rats, Wistar; Sodium Fluoride; Tibia; Trinitrobenzenesulfonic Acid | 2000 |
Role of the high affinity immunoglobulin E receptor in bacterial translocation and intestinal inflammation.
Topics: Animals; Bacteria; Base Sequence; Colitis; Disease Models, Animal; DNA Primers; Humans; Immunoglobulin E; Interleukin-4; Lymph Nodes; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Transgenic; Permeability; Receptors, IgE; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2001 |
Protective role of cyclooxygenase inhibitors in the adverse action of passive cigarette smoking on the initiation of experimental colitis in rats.
Topics: Animals; Blotting, Western; Colitis; Colon; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gene Expression Regulation, Enzymologic; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Isoenzymes; Leukotriene B4; Male; Membrane Proteins; Peroxidase; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sulfonamides; Tobacco Smoke Pollution; Trinitrobenzenesulfonic Acid | 2001 |
Tumour necrosis factor inhibitors reduce the acute-phase response in hapten-induced colitis.
Topics: Acute-Phase Reaction; Animals; Antibodies; Colitis; Haptens; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2001 |
Motilin receptor density in inflamed and noninflamed tissue in rabbit TNBS-induced colitis.
Topics: Animals; Autoradiography; Colitis; Female; Interleukin-1; Intestinal Mucosa; Male; Muscle Contraction; Peroxidase; Rabbits; Receptors, Gastrointestinal Hormone; Receptors, Interleukin-1; Receptors, Neuropeptide; Trinitrobenzenesulfonic Acid | 2001 |
Role of hypothalamic neuropeptide Y and orexigenic peptides in anorexia associated with experimental colitis in the rat.
Topics: Adaptation, Physiological; Animals; Anorexia; Blood Glucose; Body Weight; Carrier Proteins; Colitis; Corticosterone; Eating; Hypothalamic Hormones; Hypothalamus; Insulin; Intracellular Signaling Peptides and Proteins; Male; Melanins; Neuropeptide Y; Neuropeptides; Orexins; Pituitary Hormones; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Role of P-selectin and intercellular adhesion molecule-1 in TNB-induced colitis in rats.
Topics: Animals; Antibodies, Monoclonal; Colitis; Endothelium; Intercellular Adhesion Molecule-1; Intestinal Mucosa; Male; Neutrophils; P-Selectin; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Probiotic therapy fails to improve gut permeability in a hapten model of colitis.
Topics: Animals; Bacteriocins; Cell Membrane Permeability; Colitis; Ethanol; Intestines; Male; Models, Animal; Probiotics; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2000 |
Oral administration of recombinant cholera toxin subunit B inhibits IL-12-mediated murine experimental (trinitrobenzene sulfonic acid) colitis.
Topics: Administration, Oral; Administration, Rectal; Animals; Apoptosis; Cells, Cultured; Cholera Toxin; Colitis; Colon; Disease Progression; Interferon-gamma; Interleukin-10; Interleukin-12; Interleukin-4; Intestinal Mucosa; Leukocytes, Mononuclear; Male; Mice; Mice, Inbred Strains; Oxazolone; Recombinant Proteins; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2001 |
Mycophenolate mofetil reduces tissue damage and inflammation in an experimental model of colitis in rats.
Topics: Animals; Colitis; Colon; Immunosuppressive Agents; IMP Dehydrogenase; Male; Mycophenolic Acid; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2001 |
A novel water-soluble vitamin E derivative protects against experimental colitis in rats.
Topics: Animals; Antioxidants; Body Weight; Chromans; Colitis; Colon; Glycosides; Intestinal Mucosa; Lipid Peroxidation; Male; Molecular Structure; Organ Size; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Trinitrobenzenesulfonic Acid; Vitamin E | 1999 |
Inhibition of nitric oxide synthesis by aminoguanidine increases intestinal damage in the acute phase of rat TNB-colitis.
Topics: Acute Disease; Animals; Colitis; Colon; Guanidines; Liver; Male; Neutrophil Infiltration; NF-kappa B; Nitric Oxide; Prostaglandins; Proto-Oncogene Proteins; Rats; Rats, Wistar; Transcription Factor RelB; Transcription Factors; Trinitrobenzenesulfonic Acid; Up-Regulation | 2001 |
Differential role of selectins in experimental colitis.
Topics: Animals; Antibodies, Monoclonal; Body Weight; Colitis; Disease Models, Animal; E-Selectin; Endothelium, Vascular; L-Selectin; Leukocytes; Male; P-Selectin; Rats; Rats, Sprague-Dawley; Selectins; Trinitrobenzenesulfonic Acid; Venules | 2001 |
Effects of silymarin on the acute stage of the trinitrobenzenesulphonic acid model of rat colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Colitis; Female; Rats; Rats, Wistar; Silymarin; Trinitrobenzenesulfonic Acid | 2001 |
Attenuation of colon inflammation through activators of the retinoid X receptor (RXR)/peroxisome proliferator-activated receptor gamma (PPARgamma) heterodimer. A basis for new therapeutic strategies.
Topics: Animals; Colitis; Dimerization; Drug Synergism; Mice; Mice, Mutant Strains; Receptors, Cytoplasmic and Nuclear; Receptors, Retinoic Acid; Retinoid X Receptors; Rosiglitazone; Tetrahydronaphthalenes; Thiazoles; Thiazolidinediones; Transcription Factors; Transcriptional Activation; Trinitrobenzenesulfonic Acid | 2001 |
Alterations in spontaneous contractions in vitro after repeated inflammation of rat distal colon.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Gastrointestinal Motility; Guanidines; In Vitro Techniques; Inflammation; Inflammatory Bowel Diseases; Male; Muscle Contraction; Muscle, Smooth; NADPH Dehydrogenase; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Sprague-Dawley; Tetrodotoxin; Time Factors; Trinitrobenzenesulfonic Acid | 2001 |
Pattern of cytokine and adhesion molecule mRNA in hapten-induced relapsing colon inflammation in the rat.
Topics: Animals; Cell Adhesion Molecules; Chronic Disease; Colitis; Cytokines; Disease Models, Animal; Disease Progression; E-Selectin; Gene Expression Regulation; Granulocytes; Haptens; Inflammatory Bowel Diseases; Integrin beta Chains; Integrins; Intercellular Adhesion Molecule-1; Interferon-gamma; Intestinal Mucosa; Monocytes; P-Selectin; Rats; Rats, Sprague-Dawley; Recurrence; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; T-Lymphocytes; Transcription, Genetic; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1 | 2001 |
Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Death; Colitis; Colon; Disease Models, Animal; Epithelial Cells; Immunohistochemistry; In Situ Nick-End Labeling; Isoenzymes; Lysine; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Sprague-Dawley; Superoxides; Trinitrobenzenesulfonic Acid; Tyrosine | 2001 |
Amelioration of immune-mediated experimental colitis: tolerance induction in the presence of preexisting immunity and surrogate antigen bystander effect.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Immune Tolerance; Interferon-gamma; Interleukin-4; Male; Mice; Mice, Inbred BALB C; Proteins; Severity of Illness Index; Th1 Cells; Th2 Cells; Trinitrobenzenesulfonic Acid | 2001 |
An oral drug delivery system targeting immune-regulating cells ameliorates mucosal injury in trinitrobenzene sulfonic acid-induced colitis.
Topics: Administration, Oral; Animals; Cell Division; Colitis; Cyclooxygenase 1; Cytokines; Dexamethasone; Disease Models, Animal; Drug Delivery Systems; Immunohistochemistry; Intestinal Mucosa; Isoenzymes; Male; Membrane Proteins; Microspheres; NF-kappa B; Nitric Oxide; Peroxidase; Proliferating Cell Nuclear Antigen; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Treatment Outcome; Trinitrobenzenesulfonic Acid | 2001 |
Rapid imaging of experimental colitis with (99m)Tc-interleukin-8 in rabbits.
Topics: Acute Disease; Animals; Colitis; Colon; Female; Gamma Cameras; Granulocytes; Hydrazines; Interleukin-8; Niacinamide; Rabbits; Radionuclide Imaging; Radiopharmaceuticals; Technetium; Technetium Tc 99m Exametazime; Trinitrobenzenesulfonic Acid | 2001 |
N-(3-(aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats.
Topics: Amidines; Animals; Benzylamines; Blotting, Western; Colitis; Colon; Disease Models, Animal; Drug Administration Schedule; Enzyme Activation; Enzyme Inhibitors; Female; Injections, Intraperitoneal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Expression of insulin-like growth factor binding proteins and collagen in experimental colitis in rats.
Topics: Animals; Blotting, Northern; Blotting, Western; Cells, Cultured; Colitis; Collagen; Colon; Insulin-Like Growth Factor Binding Proteins; Insulin-Like Growth Factor I; Male; Muscle, Smooth; Rats; Rats, Sprague-Dawley; Rats, Wistar; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2001 |
Thalidomide impairment of trinitrobenzene sulphonic acid-induced colitis in the rat - role of endothelial cell-leukocyte interaction.
Topics: Animals; CD40 Ligand; Cell Adhesion; Colitis; Colon; Endothelium; Gene Expression Regulation; Humans; Interleukin-8; Leukocytes; Male; Mice; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Thalidomide; Trinitrobenzenesulfonic Acid; Vascular Cell Adhesion Molecule-1 | 2001 |
Suppression of acute experimental colitis by a highly selective inducible nitric-oxide synthase inhibitor, N-[3-(aminomethyl)benzyl]acetamidine.
Topics: Amidines; Animals; Anti-Inflammatory Agents; Benzylamines; Blotting, Western; Colitis; Colon; Enzyme Inhibitors; Male; Neutrophil Infiltration; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Organ Size; Peroxidase; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Trinitrobenzenesulfonic Acid | 2001 |
Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation.
Topics: 1-Methyl-3-isobutylxanthine; Acute Disease; Animals; Bacteria, Aerobic; Bacterial Toxins; Bacterial Translocation; Cell Division; Chronic Disease; Colitis; Colon; Enterotoxins; Enzyme Inhibitors; Ethanol; In Vitro Techniques; Intestinal Mucosa; Male; Mucus; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Permeability; Rats; Rats, Inbred Strains; Rats, Wistar; Remission, Spontaneous; Trinitrobenzenesulfonic Acid | 2001 |
Regulation of experimental mucosal inflammation.
Topics: Animals; Colitis; Down-Regulation; Gene Transfer Techniques; Immunotherapy; Interleukin-10; Interleukin-12; Intestinal Mucosa; Mice; Mice, Inbred Strains; T-Lymphocyte Subsets; Th1 Cells; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2001 |
Colon epithelial cellular protein induces oral tolerance in the experimental model of colitis by trinitrobenzene sulfonic acid.
Topics: Administration, Oral; Animals; Cell Extracts; Colitis; Colon; Colonic Neoplasms; Epithelium; Female; Fibroblasts; Humans; Immune Tolerance; Immunization, Passive; Interferon-gamma; Intestine, Small; Lymph Nodes; Peroxidase; Proteins; Rats; Rats, Sprague-Dawley; Rectum; Spleen; Tissue Extracts; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid; Tumor Cells, Cultured | 2001 |
Macrophage-derived IL-18-mediated intestinal inflammation in the murine model of Crohn's disease.
Topics: Animals; Antibodies; Colitis; Crohn Disease; Disease Models, Animal; Humans; Inflammation; Interleukin-18; Intestinal Mucosa; Macrophages; Mice; Mice, Inbred C57BL; Mice, Knockout; Trinitrobenzenesulfonic Acid | 2001 |
Delayed puberty and response to testosterone in a rat model of colitis.
Topics: Animals; Body Constitution; Body Weight; Colitis; Disease Models, Animal; Eating; Female; Follicle Stimulating Hormone; Genitalia, Male; Humans; Hypothalamo-Hypophyseal System; Luteinizing Hormone; Male; Nutrition Disorders; Organ Size; Pituitary-Adrenal System; Prolactin; Rats; Rats, Wistar; Sexual Maturation; Testosterone; Trinitrobenzenesulfonic Acid | 2001 |
Colitis induces CRF expression in hypothalamic magnocellular neurons and blunts CRF gene response to stress in rats.
Topics: Animals; Blood; Colitis; Colon; Corticosterone; Corticotropin-Releasing Hormone; Drinking; Eating; Gastrointestinal Motility; Gene Expression; Hypothalamus; Male; Osmolar Concentration; Rats; Rats, Sprague-Dawley; RNA, Heterogeneous Nuclear; RNA, Messenger; Stress, Physiological; Trinitrobenzenesulfonic Acid | 2001 |
Medium-chain triglyceride-rich enteral nutrition is more effective than low-fat enteral nutrition in rat colitis, but is equal in enteritis.
Topics: Animals; Body Weight; Colitis; Colon; Disease Models, Animal; Enteral Nutrition; Enteritis; Feces; Gastrostomy; Intestines; Male; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2001 |
Morphological and functional alterations of the myenteric plexus in rats with TNBS-induced colitis.
Topics: Animals; Colitis; Electric Stimulation; Immunohistochemistry; Male; Myenteric Plexus; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Changes of colonic mucosal microcirculation and histology in two colitis models: an experimental study using intravital microscopy and a new histological scoring system.
Topics: Animals; Colitis; Colon; Inflammatory Bowel Diseases; Intestinal Mucosa; Male; Microcirculation; Mitomycin; Rats; Rats, Sprague-Dawley; Time Factors; Trinitrobenzenesulfonic Acid | 2001 |
Effects of tumour necrosis factor-alpha synthesis inhibitors on rat trinitrobenzene sulphonic acid-induced chronic colitis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzamides; Chronic Disease; Colitis; Colon; Disease Models, Animal; Enzyme Inhibitors; Peroxidase; Rats; Rats, Wistar; Sulfasalazine; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2001 |
Proteinase-activated receptor 2 is an anti-inflammatory signal for colonic lamina propria lymphocytes in a mouse model of colitis.
Topics: Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cells, Cultured; Colitis; Colon; Disease Models, Animal; Down-Regulation; Enzyme Activation; Hyaluronan Receptors; Interferon-gamma; Interleukin-12; Interleukin-2; Mice; Mice, Inbred BALB C; Oligopeptides; Peptide Fragments; Receptor, PAR-2; Receptors, Thrombin; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2001 |
Blockade of endogenous IL-18 ameliorates TNBS-induced colitis by decreasing local TNF-alpha production in mice.
Topics: Animals; Body Weight; Colitis; Female; Glycoproteins; Humans; Intercellular Signaling Peptides and Proteins; Interleukin-18; Intestinal Mucosa; Mice; Mice, Inbred BALB C; Protein Isoforms; Recombinant Proteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2001 |
Intestinal anti-inflammatory activity of morin on chronic experimental colitis in the rat.
Topics: Administration, Oral; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Chronic Disease; Colitis; Disease Models, Animal; Female; Flavonoids; Interleukin-1; Intestinal Mucosa; Leukotriene B4; Nitric Oxide; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Prednisolone-appended alpha-cyclodextrin: alleviation of systemic adverse effect of prednisolone after intracolonic administration in 2,4,6-trinitrobenzenesulfonic acid-induced colitis rats.
Topics: Administration, Rectal; alpha-Cyclodextrins; Animals; Anti-Inflammatory Agents; Colitis; Colon; Cyclodextrins; Delayed-Action Preparations; Injections, Intravenous; Male; Prednisolone; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Therapeutic effect of phenantroline in two rat models of inflammatory bowel disease.
Topics: Animals; Chelating Agents; Colitis; Colon; Dextran Sulfate; Male; Metalloendopeptidases; Phenanthrolines; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid; Zinc | 2001 |
The interrelated roles of TGF-beta and IL-10 in the regulation of experimental colitis.
Topics: Adjuvants, Immunologic; Administration, Oral; Administration, Rectal; Adoptive Transfer; Animals; Antibodies, Monoclonal; CD4-Positive T-Lymphocytes; Colitis; Colon; Down-Regulation; Haptens; Interleukin-10; Lymphocyte Activation; Male; Mice; Mice, Inbred Strains; Picrates; T-Lymphocyte Subsets; Transforming Growth Factor beta; Trinitrobenzenesulfonic Acid | 2002 |
Anorexia in a rat model of colitis: interaction of interleukin-1 and hypothalamic serotonin.
Topics: Animals; Anorexia; Antibodies; Body Weight; Colitis; Disease Models, Animal; Eating; Injections, Intraventricular; Interleukin 1 Receptor Antagonist Protein; Interleukin-1; Male; Neuroimmunomodulation; Paraventricular Hypothalamic Nucleus; Rats; Rats, Wistar; Serotonin; Sialoglycoproteins; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2002 |
Effects of a COX-2 preferential agent nimesulide on TNBS-induced acute inflammation in the gut.
Topics: Acute Disease; Animals; Aspirin; Colitis; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Disease Models, Animal; Drug Evaluation, Preclinical; Indomethacin; Inflammation; Inflammatory Bowel Diseases; Isoenzymes; Male; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Sulfonamides; Trinitrobenzenesulfonic Acid | 2001 |
Lycopene supplementation attenuates the inflammatory status of colitis in a rat model.
Topics: Analysis of Variance; Animals; Antioxidants; beta Carotene; Carotenoids; Colitis; Colon; Inflammation; Lycopene; Male; Peroxidase; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 2001 |
Protective effects of Polygalae root in experimental TNBS-induced colitis in mice.
Topics: Animals; Colitis; Colon; Cytokines; Dose-Response Relationship, Drug; Female; Intestinal Mucosa; Lymphocytes; Mice; Mice, Inbred BALB C; Organ Size; Phytotherapy; Plant Extracts; Plant Roots; Polygalaceae; Spleen; Thymus Gland; Trinitrobenzenesulfonic Acid | 2002 |
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis.
Topics: Animals; Blotting, Western; Colitis; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Imidazoles; Interferon-gamma; Mice; Mice, Inbred BALB C; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pyridines; T-Lymphocytes; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha; Wasting Syndrome; Weight Loss | 2002 |
Polynitroxylated starch/TPL attenuates cachexia and increased epithelial permeability associated with TNBS colitis.
Topics: Adult; Animals; Antioxidants; Body Weight; Cachexia; Cell Adhesion; Colitis; Cyclic N-Oxides; Disease Models, Animal; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Female; Free Radicals; Humans; Hydroxyethyl Starch Derivatives; Intestinal Mucosa; Mice; Mice, Inbred Strains; Neutrophils; Nitrogen Oxides; Permeability; Spin Labels; Survival Rate; Trinitrobenzenesulfonic Acid; Umbilical Veins | 2002 |
Generalized loss of inhibitory innervation reverses serotonergic inhibition into excitation in a rabbit model of TNBS-colitis.
Topics: Animals; Colitis; Colon; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; In Vitro Techniques; Male; Muscle Contraction; Nerve Block; Neural Inhibition; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rabbits; RNA, Messenger; Serotonin; Serotonin Receptor Agonists; Trinitrobenzenesulfonic Acid | 2002 |
Effect of BP 2.94, a histamine H3-receptor agonist prodrug, on different models of colitis.
Topics: Acetic Acid; Animals; Colitis; Ethanol; Histamine Agonists; Histamine Antagonists; Imidazoles; Imines; Intestinal Mucosa; Male; Phenols; Prodrugs; Rats; Rats, Wistar; Receptors, Histamine H3; Trinitrobenzenesulfonic Acid | 2002 |
The in vitro anti-inflammatory effects of recombinant anti-CD25 immunotoxin on lamina propria T cells of patients with inflammatory bowel disease are not sufficient to cure experimental colitis in mice.
Topics: Adult; Animals; Antibodies, Monoclonal; Apoptosis; Colitis; Female; Humans; Immunotoxins; In Vitro Techniques; Inflammation; Inflammatory Bowel Diseases; Interferon-gamma; Intestinal Mucosa; Male; Mice; Mice, Inbred BALB C; Middle Aged; Receptors, Interleukin-2; Single-Chain Antibodies; T-Lymphocytes; Trinitrobenzenesulfonic Acid | 2002 |
Leptin: a pivotal mediator of intestinal inflammation in mice.
Topics: Animals; Cells, Cultured; Chemokines; Chronic Disease; Colitis; Colon; Cyclooxygenase 2; Cytokines; Dextran Sulfate; Disease Susceptibility; DNA-Binding Proteins; Enzyme Induction; Female; Intestinal Mucosa; Isoenzymes; Leptin; Lymphocytes; Mice; Mice, Inbred C57BL; Monocytes; Obesity; Prostaglandin-Endoperoxide Synthases; Reference Values; STAT3 Transcription Factor; Trans-Activators; Trinitrobenzenesulfonic Acid | 2002 |
The role of mast cells in the development of 2, 4, 6-trinitrobenzene sulfonic acid-induced colitis in rats.
Topics: Animals; Chymases; Colitis; Colon; Crohn Disease; Male; Mast Cells; Models, Animal; Rats; Serine Endopeptidases; Trinitrobenzenesulfonic Acid | 2002 |
Lactoferrin reduces colitis in rats via modulation of the immune system and correction of cytokine imbalance.
Topics: Animals; Cattle; Colitis; Colon; Cytokines; Dose-Response Relationship, Drug; Immune System; Lactoferrin; Male; NF-kappa B; Rats; Rats, Sprague-Dawley; Trinitrobenzenesulfonic Acid | 2002 |
Amelioration of dextran sulfate sodium-induced colitis by anti-macrophage migration inhibitory factor antibody in mice.
Topics: Animals; Antibodies; Cecum; Colitis; Colitis, Ulcerative; Colon; Crohn Disease; Dextran Sulfate; Humans; Immunohistochemistry; Interferon-gamma; Interleukin-4; Macrophage Migration-Inhibitory Factors; Male; Matrix Metalloproteinase 13; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; RNA, Messenger; Time Factors; Trinitrobenzenesulfonic Acid; Tumor Necrosis Factor-alpha | 2002 |
A comparative analysis of two models of colitis in rats.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Ethanol; Intestinal Mucosa; Male; Peroxidase; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
Prevention and reversal of experimental colitis by a monoclonal antibody which inhibits leukocyte adherence.
Topics: Acute Disease; Animals; Antibodies, Monoclonal; Antigens, CD; Cell Adhesion; Colitis; Epithelium; Neutrophils; Permeability; Peroxidase; Rabbits; Trinitrobenzenesulfonic Acid | 1992 |
Granulocyte infiltration in experimental colitis in the rat is interleukin-1 dependent and leukotriene independent.
Topics: Analysis of Variance; Animals; Benzopyrans; Chemotaxis, Leukocyte; Colitis; Interleukin-1; Kinetics; Leukotriene B4; Male; Neutrophils; Peroxidase; Quinolines; Rats; Rats, Wistar; Trinitrobenzenesulfonic Acid | 1992 |
Mechanism and prevention of chronic colonic inflammation with trinitrobenzene sulfonic acid in rats.
Topics: Animals; Chromatography, High Pressure Liquid; Chronic Disease; Colitis; Colon; Cyclosporine; Disease Models, Animal; Indomethacin; Male; Prostaglandins; Rats; Rats, Wistar; Thromboxane B2; Trinitrobenzenesulfonic Acid | 1992 |
Ketotifen effectively prevents mucosal damage in experimental colitis.
Topics: Acetates; Acetic Acid; Animals; Colitis; Colon; Disease Models, Animal; Intestinal Mucosa; Ketotifen; Male; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
Misoprostol therapy following trinitrobenzene sulfonic acid-induced colitis accelerates healing.
Topics: Aminosalicylic Acids; Animals; Betamethasone; Colitis; Intestinal Absorption; Intestinal Mucosa; Male; Mesalamine; Misoprostol; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1992 |
Influence of oxypurinol on colitis induced in rat colon by trinitrobenzene sulfonic acid treatment.
Topics: Adenine Nucleotides; Animals; Colitis; Colon; Guanine Nucleotides; Oxypurinol; Rats; Reference Values; Trinitrobenzenesulfonic Acid | 1991 |
Participation of thromboxane and other eicosanoid synthesis in the course of experimental inflammatory colitis.
Topics: 6-Ketoprostaglandin F1 alpha; Aminosalicylic Acids; Animals; Colitis; Dinoprostone; Indomethacin; Leukotriene B4; Male; Mesalamine; Methacrylates; Pentanoic Acids; Prednisone; Pyridines; Rats; Rats, Inbred Strains; Thromboxane B2; Thromboxane-A Synthase; Trinitrobenzenesulfonic Acid | 1990 |
Treatment with 16,16'-dimethyl prostaglandin E2 before and after induction of colitis with trinitrobenzenesulfonic acid in rats decreases inflammation.
Topics: 16,16-Dimethylprostaglandin E2; Acute Disease; Animals; Arachidonic Acid; Arachidonic Acids; Colitis; Colon; Dinoprostone; Leukotrienes; Male; Peroxidase; Prostaglandins E, Synthetic; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1989 |
Inflammatory mediators of experimental colitis in rats.
Topics: Animals; Colitis; Colon; Ethanol; Interleukin-1; Intestinal Mucosa; Leukotriene B4; Male; Peroxidase; Platelet Activating Factor; Rats; Rats, Inbred Strains; Thromboxane B2; Trinitrobenzenesulfonic Acid | 1989 |
Influence of capsaicin-sensitive fibres on experimentally-induced colitis in rats.
Topics: Acetates; Animals; Capsaicin; Colitis; Ethanol; Male; Neurons; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1989 |
Release of platelet-activating factor (PAF) and accelerated healing induced by a PAF antagonist in an animal model of chronic colitis.
Topics: Animals; Colitis; Disease Models, Animal; Diterpenes; Ginkgolides; Lactones; Male; Platelet Activating Factor; Rabbits; Rats; Rats, Inbred Strains; Trinitrobenzenesulfonic Acid | 1988 |