trimetrexate has been researched along with Uterine Cervical Dysplasia in 1 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Uterine Cervical Dysplasia: Abnormal development of immature squamous EPITHELIAL CELLS of the UTERINE CERVIX, a term used to describe premalignant cytological changes in the cervical EPITHELIUM. These atypical cells do not penetrate the epithelial BASEMENT MEMBRANE.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results would support consideration of a phase II study to determine the effectiveness of trimetrexate for recurrent intra-ocular retinoblastoma." | 3.74 | Impairments in antifolate transport are common in retinoblastoma tumor samples. ( Abramson, DH; Dunkel, IJ; Gorlick, RG; Mazza, BA; Sowers, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorlick, RG | 1 |
| Abramson, DH | 1 |
| Sowers, R | 1 |
| Mazza, BA | 1 |
| Dunkel, IJ | 1 |
1 other study available for trimetrexate and Uterine Cervical Dysplasia
| Article | Year |
|---|---|
Impairments in antifolate transport are common in retinoblastoma tumor samples.
Topics: Adolescent; Antimetabolites, Antineoplastic; Binding, Competitive; Biological Transport; Child; Drug | 2008 |