trimetrexate has been researched along with Soft Tissue Neoplasms in 5 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A human fibrosarcoma cell line, HT-1080, and four new cell lines (HS-16, HS-28, HS-30, and HS-42) were established from untreated patients with mesenchymal chondrosarcoma, peripheral nerve sheath sarcoma, malignant hemangiopericytoma, and mixed mesodermal tumor, respectively, and were used for analysis of mechanisms of intrinsic resistance to methotrexate." | 7.68 | Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. ( Bertino, JR; Li, WW; Lin, JT; Niedzwiecki, D; Schweitzer, BI; Tong, WP, 1992) |
| "Trimetrexate has shown promising activity in animal model systems." | 5.28 | Phase II trial of trimetrexate in patients with advanced soft-tissue sarcoma. ( Antman, KH; Gonin, R; Licht, JD, 1991) |
| "A human fibrosarcoma cell line, HT-1080, and four new cell lines (HS-16, HS-28, HS-30, and HS-42) were established from untreated patients with mesenchymal chondrosarcoma, peripheral nerve sheath sarcoma, malignant hemangiopericytoma, and mixed mesodermal tumor, respectively, and were used for analysis of mechanisms of intrinsic resistance to methotrexate." | 3.68 | Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines. ( Bertino, JR; Li, WW; Lin, JT; Niedzwiecki, D; Schweitzer, BI; Tong, WP, 1992) |
| "A human lymphoblastoid line (RPMI-1788), a methotrexate-sensitive human fibrosarcoma cell line (HT-1080), and a naturally resistant mixed mesodermal human sarcoma cell line with impaired methotrexate polyglutamylation (HS-42), recently established in our laboratory, were used to compare the ability of leucovorin to prevent trimetrexate cytotoxicity." | 3.68 | Inability of leucovorin to rescue a naturally methotrexate-resistant human soft tissue sarcoma cell line from trimetrexate cytotoxicity. ( Bertino, JR; Li, WW, 1992) |
| "Trimetrexate has shown promising activity in animal model systems." | 1.28 | Phase II trial of trimetrexate in patients with advanced soft-tissue sarcoma. ( Antman, KH; Gonin, R; Licht, JD, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, WW | 3 |
| Lin, JT | 2 |
| Tong, WP | 2 |
| Trippett, TM | 1 |
| Brennan, MF | 1 |
| Bertino, JR | 3 |
| Schweitzer, BI | 1 |
| Niedzwiecki, D | 1 |
| Licht, JD | 1 |
| Gonin, R | 1 |
| Antman, KH | 1 |
| Eisenhauer, EA | 1 |
| Wierzbicki, R | 1 |
| Knowling, M | 1 |
| Bramwell, VH | 1 |
| Quirt, IC | 1 |
5 other studies available for trimetrexate and Soft Tissue Neoplasms
| Article | Year |
|---|---|
Mechanisms of natural resistance to antifolates in human soft tissue sarcomas.
Topics: Aminopterin; Chromatography, High Pressure Liquid; Drug Resistance; Folic Acid Antagonists; Humans; | 1992 |
Intrinsic resistance to methotrexate in human soft tissue sarcoma cell lines.
Topics: Drug Resistance; Humans; Methotrexate; Peptide Synthases; Polyglutamic Acid; Sarcoma; Soft Tissue Ne | 1992 |
Inability of leucovorin to rescue a naturally methotrexate-resistant human soft tissue sarcoma cell line from trimetrexate cytotoxicity.
Topics: Drug Resistance; Fibrosarcoma; Folic Acid; Humans; Leucovorin; Methotrexate; Pteroylpolyglutamic Aci | 1992 |
Phase II trial of trimetrexate in patients with advanced soft-tissue sarcoma.
Topics: Antineoplastic Agents; Drug Evaluation; Folic Acid Antagonists; Humans; Infusions, Intravenous; Quin | 1991 |
Phase II trials of trimetrexate in advanced adult soft tissue sarcoma. Studies of the Canadian Sarcoma Group and the National Cancer Institute of Canada Clinical Trials Group.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Canada; Clinical Trials as Topic; Drug Administration Sc | 1991 |