trimetrexate has been researched along with Retinoblastoma in 1 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Retinoblastoma: A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
| Excerpt | Relevance | Reference |
|---|---|---|
| "These results would support consideration of a phase II study to determine the effectiveness of trimetrexate for recurrent intra-ocular retinoblastoma." | 3.74 | Impairments in antifolate transport are common in retinoblastoma tumor samples. ( Abramson, DH; Dunkel, IJ; Gorlick, RG; Mazza, BA; Sowers, R, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gorlick, RG | 1 |
| Abramson, DH | 1 |
| Sowers, R | 1 |
| Mazza, BA | 1 |
| Dunkel, IJ | 1 |
1 other study available for trimetrexate and Retinoblastoma
| Article | Year |
|---|---|
Impairments in antifolate transport are common in retinoblastoma tumor samples.
Topics: Adolescent; Antimetabolites, Antineoplastic; Binding, Competitive; Biological Transport; Child; Drug | 2008 |