trimetrexate has been researched along with Pneumocystis Infections in 5 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Pneumocystis Infections: Infections with species in the genus PNEUMOCYSTIS, a fungus causing interstitial plasma cell pneumonia (PNEUMONIA, PNEUMOCYSTIS) and other infections in humans and other MAMMALS. Immunocompromised patients, especially those with AIDS, are particularly susceptible to these infections. Extrapulmonary sites are rare but seen occasionally.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimetrexate is an agent that does not require uptake by the folate carrier transport system, a major mechanism of cellular resistance both in vitro and in vivo." | 2.39 | Clinical pharmacokinetics and pharmacology of trimetrexate. ( DeLap, RJ; Marshall, JL, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (80.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gangjee, A | 1 |
| Shi, J | 1 |
| Queener, SF | 1 |
| Barrows, LR | 1 |
| Kisliuk, RL | 1 |
| Ma, L | 1 |
| Jia, Q | 1 |
| Kovacs, JA | 1 |
| Marshall, JL | 1 |
| DeLap, RJ | 1 |
| Fishman, JA | 1 |
2 reviews available for trimetrexate and Pneumocystis Infections
| Article | Year |
|---|---|
Clinical pharmacokinetics and pharmacology of trimetrexate.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Dose-Response Rel | 1994 |
Treatment of infection due to Pneumocystis carinii.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Atovaquone; Clindamycin; Dapsone; Eflornithine; Humans | 1998 |
3 other studies available for trimetrexate and Pneumocystis Infections
| Article | Year |
|---|---|
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Topics: Animals; Antineoplastic Agents; Disease Models, Animal; Folic Acid Antagonists; Fungal Proteins; Hum | 1993 |
Development of a yeast assay for rapid screening of inhibitors of human-derived Pneumocystis carinii dihydrofolate reductase.
Topics: Animals; Drug Evaluation, Preclinical; Folic Acid Antagonists; Humans; Pneumocystis; Pneumocystis In | 2002 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |