trimetrexate has been researched along with P carinii Pneumonia in 41 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of clindamycin plus primaquine appears to be the most effective alternative treatment for patients with P carinii pneumonia who are unresponsive to conventional antipneumocystis agents." | 4.81 | A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia. ( Maloba, B; Nagar, S; Popara, M; Smego, RA, 2001) |
| " Serial blood samples were obtained over 24 hours after dosing and analyzed for trimetrexate, dapsone, and monoacetyldapsone, and pharmacokinetic parameters were determined." | 2.69 | Pharmacokinetics of trimetrexate and dapsone in AIDS patients with Pneumocystis carinii pneumonia. ( Chatterjee, DJ; Dubé, MP; Koda, RT; Li, WY; Sattler, FR; Stansell, JD, 1999) |
| "Trimetrexate is a powerful inhibitor of the dihydrofolate reductase of Pneumocystis carinii." | 2.67 | Trimetrexate with leucovorin versus trimethoprim-sulfamethoxazole for moderate to severe episodes of Pneumocystis carinii pneumonia in patients with AIDS: a prospective, controlled multicenter investigation of the AIDS Clinical Trials Group Protocol 029/0 ( Akil, B; Baughman, R; Boylen, CT; Davis, R; Frame, P; Hughlett, C; Nichols, L; Sattler, FR; Shelton, B; Weiss, W, 1994) |
| "Trimetrexate is a folinic acid analogue structurally related to methotrexate, whose primary mechanism of action is believed to be inhibition of dihydrofolate reductase." | 2.39 | Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia. ( Fulton, B; McTavish, D; Wagstaff, AJ, 1995) |
| " Pharmacokinetic data and clinical trials are reviewed, as well as adverse effects, drug interactions, and dosage guidelines." | 2.38 | Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS. ( Amsden, GW; Kowalsky, SF; Morse, GD, 1992) |
| "The diagnosis of Pneumocystis carinii pneumonia (PCP) rests on the isolation of this micro-organism in patients whose latest blood count, less than 2 months old, shows less than 250 CD4 lymphocytes per cubic mm and who present with signs of impaired lung function." | 2.38 | [Pneumocystis carinii pneumonia in HIV infection. Diagnosis, prognostic factors and curative treatment]. ( Girard, PM; Saimot, AG, 1991) |
| "Trimetrexate was tolerated in 100% of cases with no treatment termination secondary to adverse drug reactions." | 1.35 | Trimetrexate and folinic acid: a valuable salvage option for Pneumocystis jirovecii pneumonia. ( Churchill, DR; Fisher, MJ; Gilleece, YC; Short, CE, 2009) |
| "To determine the maximal tolerable dosage of trimetrexate for treatment of pneumocystis pneumonia, 25 patients were treated each day with 45 mg/m2 of trimetrexate and 80 mg/m2 of leucovorin; 10 received 60 mg/m2 and 80 mg/m2; 12 received 60 mg/m2 and 160 mg/m2; and 6 received 90 mg/m2 and 160 mg/m2, respectively." | 1.28 | Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia. ( Akil, B; Allegra, CJ; Feinberg, J; Hughlett, C; Lane, HC; Ogata-Arakaki, D; Sattler, FR; Shelhamer, J; Tuazon, CU; Verdegem, TD, 1990) |
| "Both trimetrexate and BW301U were effective as prophylactic agents against P." | 1.27 | Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection. ( Bartlett, MS; Durkin, MM; Jay, MA; Queener, SF; Smith, JW, 1987) |
| "Rats treated with trimetrexate (25 mg/kg/d) plus sulfamethoxazole (250 mg/kg/d) orally responded at least as well as rats treated with trimethoprim (50 mg/kg/d) plus sulfamethoxazole." | 1.27 | Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia. ( Allegra, CJ; Chabner, B; Drake, J; Kennedy, S; Kovacs, JA; Masur, H; Parrillo, JE; Swan, JC, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (31.71) | 18.7374 |
| 1990's | 25 (60.98) | 18.2507 |
| 2000's | 2 (4.88) | 29.6817 |
| 2010's | 1 (2.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Queener, SF | 3 |
| Kuyper, LF | 1 |
| Baccanari, DP | 1 |
| Jones, ML | 1 |
| Hunter, RN | 1 |
| Tansik, RL | 1 |
| Joyner, SS | 1 |
| Boytos, CM | 1 |
| Rudolph, SK | 1 |
| Knick, V | 1 |
| Wilson, HR | 1 |
| Caddell, JM | 1 |
| Friedman, HS | 1 |
| Comley, JC | 1 |
| Stables, JN | 1 |
| Piper, JR | 1 |
| Johnson, CA | 1 |
| Krauth, CA | 1 |
| Carter, RL | 1 |
| Hosmer, CA | 1 |
| Borotz, SE | 1 |
| Pfefferkorn, ER | 1 |
| Short, CE | 1 |
| Gilleece, YC | 1 |
| Fisher, MJ | 1 |
| Churchill, DR | 1 |
| Borde, JP | 1 |
| Offensperger, WB | 1 |
| de With, K | 1 |
| Fulton, B | 1 |
| Wagstaff, AJ | 1 |
| McTavish, D | 1 |
| Pastor, C | 1 |
| Lumbreras, C | 1 |
| Lizasoain, M | 1 |
| Sattler, FR | 4 |
| Frame, P | 1 |
| Davis, R | 1 |
| Nichols, L | 1 |
| Shelton, B | 1 |
| Akil, B | 2 |
| Baughman, R | 1 |
| Hughlett, C | 2 |
| Weiss, W | 1 |
| Boylen, CT | 1 |
| Freij, BJ | 1 |
| Wientzen, RL | 1 |
| Hayek, G | 1 |
| Whitfield, LR | 2 |
| Voelker, R | 1 |
| Nightingale, SL | 2 |
| Korraa, H | 1 |
| Saadeh, C | 1 |
| Deresinski, SC | 1 |
| Fishman, JA | 1 |
| Koda, RT | 1 |
| Dubé, MP | 1 |
| Li, WY | 1 |
| Chatterjee, DJ | 1 |
| Stansell, JD | 1 |
| Harris, PJ | 1 |
| Blanchet, KD | 1 |
| Smego, RA | 1 |
| Nagar, S | 1 |
| Maloba, B | 1 |
| Popara, M | 1 |
| Feinberg, J | 2 |
| Amsden, GW | 1 |
| Kowalsky, SF | 1 |
| Morse, GD | 1 |
| Saimot, AG | 1 |
| Girard, PM | 1 |
| Vinogradov, NA | 1 |
| Allegra, CJ | 4 |
| Verdegem, TD | 1 |
| Tuazon, CU | 3 |
| Ogata-Arakaki, D | 3 |
| Shelhamer, J | 1 |
| Lane, HC | 1 |
| Davey, RT | 1 |
| Masur, H | 4 |
| Faber, HJ | 1 |
| Sprenger, HG | 1 |
| Weits, J | 1 |
| Smit, MJ | 1 |
| De Groot, R | 1 |
| Van Dongen, JJ | 1 |
| Van der Voort, E | 1 |
| Neijens, HJ | 1 |
| Bartlett, MS | 1 |
| Jay, MA | 1 |
| Durkin, MM | 1 |
| Smith, JW | 1 |
| Montgomery, AB | 1 |
| Young, FE | 1 |
| Hughes, WT | 1 |
| Chabner, BA | 2 |
| Baird, B | 2 |
| Drake, JC | 2 |
| Simmons, JT | 1 |
| Lack, EE | 1 |
| Shelhamer, JH | 1 |
| Balis, F | 1 |
| Kovacs, JA | 2 |
| Kennedy, S | 1 |
| Swan, JC | 1 |
| Drake, J | 1 |
| Parrillo, JE | 1 |
| Chabner, B | 1 |
| Fischl, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00001014] | Phase 3 | 302 participants | Interventional | Completed | |||
| A Randomized, Comparative, Double-Blind Trial of Trimetrexate (CI-898) With Leucovorin Calcium Rescue Versus Trimethoprim / Sulfamethoxazole for Moderately Severe Pneumocystis Carinii Pneumonia in Patients With AIDS[NCT00001013] | Phase 3 | 364 participants | Interventional | Completed | |||
| A Randomized, Comparative Trial of Trimetrexate With Leucovorin Rescue Versus Standard Anti-Pneumocystis Therapy Versus Standard Anti-Pneumocystis Therapy With High Dose Steroids for AIDS Patients With Pneumocystis Pneumonia Who Appear to Be Refractory to[NCT00000730] | Phase 3 | 240 participants | Interventional | Terminated | |||
| Evaluation of Escalating Doses of Intravenous Trimetrexate as Therapy for Previously Untreated Pneumocystis Carinii Pneumonia in AIDS Patients With Subsequent Comparison of Intravenous and Oral Pharmacokinetics[NCT00000998] | Phase 1 | 50 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
15 reviews available for trimetrexate and P carinii Pneumonia
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infectio | 1995 |
[Diagnosis and treatment of pneumocystis jirovecii pneumonia].
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Agents; Atovaquone; Broncho | 2011 |
Trimetrexate. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of Pneumocystis carinii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Animals; Clinical Trials as Topic; Humans; Pneumonia, Pneumoc | 1995 |
[Current alternatives in the treatment of Pneumocystis carinii pneumonia in patients with AIDS].
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Atovaquone; Clindamycin; Dapsone; Eflornit | 1994 |
Options in the management of pneumonia caused by Pneumocystis carinii in patients with acquired immune deficiency syndrome and intolerance to trimethoprim/sulfamethoxazole.
Topics: Adrenal Cortex Hormones; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Ag | 1996 |
Treatment of Pneumocystis carinii pneumonia in adults with AIDS.
Topics: Administration, Oral; Adult; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifunga | 1997 |
Treatment of infection due to Pneumocystis carinii.
Topics: Anti-Bacterial Agents; Anti-Infective Agents; Atovaquone; Clindamycin; Dapsone; Eflornithine; Humans | 1998 |
A meta-analysis of salvage therapy for Pneumocystis carinii pneumonia.
Topics: Adolescent; Adult; Aged; AIDS-Related Opportunistic Infections; Child; Child, Preschool; Clindamycin | 2001 |
Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole | 1992 |
[Pneumocystis carinii pneumonia in HIV infection. Diagnosis, prognostic factors and curative treatment].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; CD4-Positive T-Lymphocytes; Dapsone; Eflornithine; F | 1991 |
[Diagnosis and treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Diagnosis, Differential; Humans; Pneumonia, Pneumoc | 1991 |
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Humans; Opportunistic Infections; Pneumon | 1990 |
Recent developments in the therapy and management of Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Therapy, Combination; Humans; Pentamidine; Pneumon | 1989 |
Pneumocystis carinii pneumonia: therapy and prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy, | 1988 |
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Antiprotozoal Agents; Clinical Trials a | 1988 |
3 trials available for trimetrexate and P carinii Pneumonia
24 other studies available for trimetrexate and P carinii Pneumonia
| Article | Year |
|---|---|
High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B | 1996 |
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneu | 1996 |
Trimetrexate and folinic acid: a valuable salvage option for Pneumocystis jirovecii pneumonia.
Topics: Adult; AIDS-Related Opportunistic Infections; Antifungal Agents; Drug Evaluation; Drug Therapy, Comb | 2009 |
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
FDA approves trimetrexate as second-line therapy for Pneumocystis carinii pneumonia.
Topics: Humans; Pneumonia, Pneumocystis; Trimetrexate; United States; United States Food and Drug Administra | 1994 |
Pharmacokinetics of trimetrexate glucuronate in infants with AIDS and Pneumocystis carinii pneumonia.
Topics: AIDS-Related Opportunistic Infections; Drug Combinations; Female; Glucuronates; Humans; Infant; Male | 1993 |
More choices in treating AIDS-related pneumonia.
Topics: AIDS-Related Opportunistic Infections; Antifungal Agents; Drug Approval; Drug Combinations; Glucuron | 1994 |
From the Food and Drug Administration.
Topics: Cystic Fibrosis; Deoxyribonuclease I; Deoxyribonucleases; Drug Approval; Drug Therapy, Combination; | 1994 |
Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect.
Topics: Adult; AIDS-Related Opportunistic Infections; Antineoplastic Agents; Drug Combinations; Glucuronates | 1996 |
Current management practices in the treatment of Pneumocystis carinii pneumonia (PCP).
Topics: AIDS-Related Opportunistic Infections; Algorithms; Anti-Infective Agents; Antifungal Agents; Dapsone | 1996 |
New developments in the treatment of Pneumocystis carinii pneumonia.
Topics: Adrenal Cortex Hormones; Aerosols; Dapsone; Drug Therapy, Combination; Eflornithine; Folic Acid Anta | 1992 |
Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Drug T | 1990 |
Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative.
Topics: Acquired Immunodeficiency Syndrome; Adult; Folic Acid Antagonists; Humans; Male; Pneumonia, Pneumocy | 1990 |
Trimetrexate efficacy and pharmacokinetics during treatment of refractory Pneumocystis carinii pneumonia in an infant with severe combined immunodeficiency disease.
Topics: Antifungal Agents; Drug Combinations; Glucuronates; Humans; Immunologic Deficiency Syndromes; Infant | 1990 |
Activity of lipid-soluble inhibitors of dihydrofolate reductase against Pneumocystis carinii in culture and in a rat model of infection.
Topics: Animals; Cells, Cultured; Folic Acid Antagonists; Humans; Pneumocystis; Pneumonia, Pneumocystis; Pyr | 1987 |
AIDS drug available.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Glucuronates; Humans; Pneumonia, Pneumocystis | 1988 |
Trimetrexate for Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Leukopenia; Pneum | 1989 |
FDA's newly designated treatment INDs.
Topics: Clinical Protocols; Cytomegalovirus; Cytomegalovirus Infections; Drug Combinations; Drug Therapy, Co | 1988 |
Pneumocystis carinii pneumonitis.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Pneumonia, Pneumo | 1987 |
Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Evaluation; Drug Therapy, Combination; Female; Folic | 1987 |
Treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Combinations; Folic Acid Antagonists; Humans; Meth | 1987 |
Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Female; Humans; Male; Middle Aged; | 1988 |
[AIDS. Trimetrexate--alternative in Pneumocystis carinii pneumonia].
Topics: Acquired Immunodeficiency Syndrome; Humans; Opportunistic Infections; Pneumonia, Pneumocystis; Quina | 1988 |
Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia.
Topics: Administration, Oral; Animals; Drug Therapy, Combination; Folic Acid Antagonists; Injections, Subcut | 1988 |