trimetrexate has been researched along with Opportunistic Infections in 7 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (14.29) | 18.7374 |
| 1990's | 3 (42.86) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Queener, SF | 4 |
| Piper, JR | 1 |
| Johnson, CA | 1 |
| Krauth, CA | 1 |
| Carter, RL | 1 |
| Hosmer, CA | 1 |
| Borotz, SE | 1 |
| Pfefferkorn, ER | 1 |
| Gangjee, A | 1 |
| Adair, OO | 1 |
| Bag, S | 1 |
| Tawari, NR | 1 |
| Degani, MS | 1 |
| Borde, JP | 1 |
| Offensperger, WB | 1 |
| de With, K | 1 |
| Davey, RT | 1 |
| Masur, H | 1 |
3 reviews available for trimetrexate and Opportunistic Infections
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infectio | 1995 |
[Diagnosis and treatment of pneumocystis jirovecii pneumonia].
Topics: AIDS-Related Opportunistic Infections; Anti-Infective Agents; Antifungal Agents; Atovaquone; Broncho | 2011 |
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Humans; Opportunistic Infections; Pneumon | 1990 |
4 other studies available for trimetrexate and Opportunistic Infections
| Article | Year |
|---|---|
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneu | 1996 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cricetinae; Drug | 2003 |
Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Topics: Animals; Biguanides; Computer Simulation; Drug Design; Folic Acid Antagonists; Liver; Microbial Sens | 2010 |
[AIDS. Trimetrexate--alternative in Pneumocystis carinii pneumonia].
Topics: Acquired Immunodeficiency Syndrome; Humans; Opportunistic Infections; Pneumonia, Pneumocystis; Quina | 1988 |