trimetrexate has been researched along with Local Neoplasm Recurrence in 5 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "This study was conducted to determine the objective response of trimetrexate in patients with advanced or recurrent leiomyosarcoma of the uterus." | 9.10 | Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group. ( Blessing, JA; Smith, HO; Vaccarello, L, 2002) |
| "The purpose of this report is to evaluate the efficacy and toxicity (Tx) of a double modulation of 5-fluorouracil (5-FU) by trimetrexate (TMTX) and leucovorin (LV) in patients with advanced recurrent (inoperable) or metastatic colorectal cancer (ACC)." | 5.11 | Double modulation of 5-fluorouracil by trimetrexate and leucovorin in patients with advanced colorectal carcinoma. ( Bologna, F; Dominguez, ME; Lacava, JA; Leone, BA; Machiavelli, MR; Ortiz, EH; Pérez, JE; Romero, AO; Salum, G; Vallejo, CT, 2004) |
| "This study was conducted to determine the objective response of trimetrexate in patients with advanced or recurrent leiomyosarcoma of the uterus." | 5.10 | Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group. ( Blessing, JA; Smith, HO; Vaccarello, L, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Machiavelli, MR | 1 |
| Salum, G | 1 |
| Pérez, JE | 1 |
| Ortiz, EH | 1 |
| Romero, AO | 1 |
| Bologna, F | 1 |
| Vallejo, CT | 1 |
| Lacava, JA | 1 |
| Dominguez, ME | 1 |
| Leone, BA | 1 |
| Smith, HO | 1 |
| Blessing, JA | 2 |
| Vaccarello, L | 1 |
| Fowler, JM | 1 |
| Burger, RA | 1 |
| Malfetano, JH | 1 |
| Sarris, AH | 1 |
| Phan, A | 1 |
| Duvic, M | 1 |
| Romaguera, J | 1 |
| McLaughlin, P | 1 |
| Mesina, O | 1 |
| King, K | 1 |
| Medeiros, LJ | 1 |
| Rassidakis, GZ | 1 |
| Samuels, B | 1 |
| Cabanillas, F | 1 |
| Weiss, GR | 1 |
| Liu, PY | 1 |
| O'Sullivan, J | 1 |
| Alberts, DS | 1 |
| Brown, TD | 1 |
| Neefe, JR | 1 |
| Hutchins, LF | 1 |
5 trials available for trimetrexate and Local Neoplasm Recurrence
| Article | Year |
|---|---|
Double modulation of 5-fluorouracil by trimetrexate and leucovorin in patients with advanced colorectal carcinoma.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Fluorouracil; Hu | 2004 |
Trimetrexate in the treatment of recurrent or advanced leiomyosarcoma of the uterus: a phase II study of the Gynecologic Oncology Group.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Drug Administration Schedule; Fe | 2002 |
Phase II evaluation of oral trimetrexate in mixed mesodermal tumors of the uterus: a gynecologic oncology group study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Administration | 2002 |
Trimetrexate in relapsed T-cell lymphoma with skin involvement.
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Resistance, Neoplasm; Female; Humans; | 2002 |
A randomized phase II trial of trimetrexate or didemnin B for the treatment of metastatic or recurrent squamous carcinoma of the uterine cervix: a Southwest Oncology Group trial.
Topics: Antineoplastic Agents; Carcinoma, Squamous Cell; Depsipeptides; Female; Humans; Neoplasm Recurrence, | 1992 |