trimetrexate and Leukopenia studies

trimetrexate and Leukopenia

trimetrexate has been researched along with Leukopenia in 4 studies

Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Leukopenia: A decrease in the number of LEUKOCYTES in a blood sample below the normal range (LEUKOCYTE COUNT less than 4000).

Research Excerpts

Excerpt	Relevance	Reference
" TMTX plasma concentrations were measured after the first dose and the data were fit by two- or three-compartment mammillary pharmacokinetic models."	1.28	A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics. ( Donehower, RC; Ettinger, DS; Grochow, LB; Noe, DA, 1989)

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (50.00)	18.7374
1990's	2 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

2 (50.00)

18.7374

1990's

2 (50.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Witte, RS	1
Yeap, BY	1
Trump, DL	1
Pappo, AS	1
Vats, T	1
Williams, TE	1
Bernstein, M	1
Kamen, BA	1
Grochow, LB	1
Noe, DA	1
Ettinger, DS	1
Donehower, RC	1

Studies

Witte, RS

Yeap, BY

Trump, DL

Pappo, AS

Vats, T

Williams, TE

Bernstein, M

Kamen, BA

Grochow, LB

Noe, DA

Ettinger, DS

Donehower, RC

Trials

2 trials available for trimetrexate and Leukopenia

Article	Year
Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial. Investigational new drugs, 1994, Volume: 12, Issue:3 Topics: Aged; Anemia; Humans; Leukopenia; Male; Middle Aged; Prostatic Neoplasms; Thrombocytopenia; Treatmen	1994
Phase I trial of trimetrexate in pediatric solid tumors: a Pediatric Oncology Group study. Medical and pediatric oncology, 1993, Volume: 21, Issue:4 Topics: Adolescent; Adult; Brain Neoplasms; Carcinoma, Renal Cell; Child; Child, Preschool; Female; Follow-U	1993

Article

Year

Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial.

Investigational new drugs, 1994, Volume: 12, Issue:3

Topics: Aged; Anemia; Humans; Leukopenia; Male; Middle Aged; Prostatic Neoplasms; Thrombocytopenia; Treatmen

1994

Phase I trial of trimetrexate in pediatric solid tumors: a Pediatric Oncology Group study.

Medical and pediatric oncology, 1993, Volume: 21, Issue:4

Topics: Adolescent; Adult; Brain Neoplasms; Carcinoma, Renal Cell; Child; Child, Preschool; Female; Follow-U

1993

Other Studies

2 other studies available for trimetrexate and Leukopenia

Article	Year
Trimetrexate for Pneumocystis carinii pneumonia. The Medical letter on drugs and therapeutics, 1989, Jan-27, Volume: 31, Issue:784 Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Leukopenia; Pneum	1989
A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics. Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:5 Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Dose-Response Relationship, Drug; Drug Combinations	1989

Article

Year

Trimetrexate for Pneumocystis carinii pneumonia.

The Medical letter on drugs and therapeutics, 1989, Jan-27, Volume: 31, Issue:784

Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Leukopenia; Pneum

1989

A phase I trial of trimetrexate glucuronate (NSC 352122) given every 3 weeks: clinical pharmacology and pharmacodynamics.

Cancer chemotherapy and pharmacology, 1989, Volume: 24, Issue:5

Topics: Adult; Aged; Antineoplastic Agents; Bone Marrow; Dose-Response Relationship, Drug; Drug Combinations

1989