trimetrexate has been researched along with Leucocythaemia in 12 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven adult patients with refractory acute leukemia were administered trimetrexate (TMTX), a non-classical folate antagonist, in a phase I trial." | 9.07 | A phase I trial of trimetrexate (NSC352122) on a daily x 5 schedule in patients with refractory adult leukemia. ( Balis, FM; Brown, TD; Craig, JB; Denham, CA; Havlin, K; Kuhn, JG; Rodriguez, G; Von Hoff, DD, 1993) |
| "Cellular methotrexate (MTX) resistance may cause treatment failure in childhood common/preB-acute lymphoblastic leukemia (c/preB-ALL), T-lineage ALL (T-ALL), and acute myeloid leukemia (AML)." | 7.70 | Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates. ( Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC, 1999) |
| "The mechanism of acquired methotrexate-resistance in an estrogen-receptor positive human breast cancer cell line (MTX(R)ZR-75-1) was studied." | 7.68 | Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line. ( Cowan, KH; Dixon, KH; Eng, SC; Trepel, JB, 1991) |
| "Twenty-five samples of fresh malignant cells of patients with acute leukemia (16 with acute myeloblastic leukemia, five with acute lymphoblastic leukemia, and four with chronic myelocytic leukemia in blast crisis) and of two patients with colon carcinoma were exposed for 1 hr to different concentrations of methotrexate (MTX) or trimetrexate (TMQ)." | 7.67 | Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells. ( Bertino, JR; McGuire, JJ; Rodenhuis, S; Sawicki, WL, 1987) |
| "Seven adult patients with refractory acute leukemia were administered trimetrexate (TMTX), a non-classical folate antagonist, in a phase I trial." | 5.07 | A phase I trial of trimetrexate (NSC352122) on a daily x 5 schedule in patients with refractory adult leukemia. ( Balis, FM; Brown, TD; Craig, JB; Denham, CA; Havlin, K; Kuhn, JG; Rodriguez, G; Von Hoff, DD, 1993) |
| "CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective transport via the reduced folate carrier (RFC)." | 3.70 | A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance. ( Assaraf, YG; Bunni, M; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Schornagel, JH; Sprecher, H, 1998) |
| "Cellular methotrexate (MTX) resistance may cause treatment failure in childhood common/preB-acute lymphoblastic leukemia (c/preB-ALL), T-lineage ALL (T-ALL), and acute myeloid leukemia (AML)." | 3.70 | Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates. ( Creutzig, U; Hählen, K; Janka-Schaub, G; Jansen, G; Kaspers, GJ; Mauritz, R; Noordhuis, P; Peters, GJ; Pieters, R; Rots, MG; van Zantwijk, CH; Veerman, AJ; Willey, JC, 1999) |
| "The mechanism of acquired methotrexate-resistance in an estrogen-receptor positive human breast cancer cell line (MTX(R)ZR-75-1) was studied." | 3.68 | Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line. ( Cowan, KH; Dixon, KH; Eng, SC; Trepel, JB, 1991) |
| "In order to clarify a molecular mechanism of folate resistance in leukemia cells, we studied alterations of the dihydrofolate reductase (DHFR) gene in a human leukemia cell line, MOLT-3, and its sublines made resistant to methotrexate (MTX), trimetrexate (TMQ) and N10-propargyl-5,8-dideazafolic acid (CB3717), alone or in combination." | 3.68 | Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues. ( Ando, K; Ando, Y; Kobayashi, H; Miyachi, H; Takemura, Y, 1993) |
| "Twenty-five samples of fresh malignant cells of patients with acute leukemia (16 with acute myeloblastic leukemia, five with acute lymphoblastic leukemia, and four with chronic myelocytic leukemia in blast crisis) and of two patients with colon carcinoma were exposed for 1 hr to different concentrations of methotrexate (MTX) or trimetrexate (TMQ)." | 3.67 | Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells. ( Bertino, JR; McGuire, JJ; Rodenhuis, S; Sawicki, WL, 1987) |
| "Trimetrexate (TMQ) is a lipophilic antifolate shown to have antitumor activity in humans." | 1.28 | Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate. ( Arkin, H; Holland, JF; Kamen, BA; Ohnuma, T; Vallabhajosula, S, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (33.33) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dixon, KH | 1 |
| Trepel, JB | 1 |
| Eng, SC | 1 |
| Cowan, KH | 1 |
| Miyachi, H | 3 |
| Takemura, Y | 3 |
| Kobayashi, H | 3 |
| Ando, K | 1 |
| Ando, Y | 2 |
| Rodriguez, G | 1 |
| Brown, TD | 1 |
| Balis, FM | 1 |
| Craig, JB | 1 |
| Denham, CA | 1 |
| Kuhn, JG | 1 |
| Havlin, K | 1 |
| Von Hoff, DD | 1 |
| Jansen, G | 4 |
| Mauritz, R | 3 |
| Drori, S | 2 |
| Sprecher, H | 1 |
| Kathmann, I | 1 |
| Bunni, M | 1 |
| Priest, DG | 1 |
| Noordhuis, P | 2 |
| Schornagel, JH | 2 |
| Pinedo, HM | 1 |
| Peters, GJ | 3 |
| Assaraf, YG | 2 |
| Ma, L | 1 |
| Hirahara, I | 1 |
| Sonehara, H | 1 |
| Rots, MG | 1 |
| Pieters, R | 1 |
| van Zantwijk, CH | 1 |
| Willey, JC | 1 |
| Hählen, K | 1 |
| Creutzig, U | 1 |
| Janka-Schaub, G | 1 |
| Kaspers, GJ | 1 |
| Veerman, AJ | 1 |
| van der Veer, LJ | 1 |
| Westerhof, GR | 1 |
| Rijksen, G | 1 |
| Arkin, H | 1 |
| Ohnuma, T | 1 |
| Kamen, BA | 1 |
| Holland, JF | 1 |
| Vallabhajosula, S | 1 |
| Rodenhuis, S | 2 |
| McGuire, JJ | 2 |
| Narayanan, R | 1 |
| Bertino, JR | 2 |
| Sawicki, WL | 1 |
1 review available for trimetrexate and Leucocythaemia
| Article | Year |
|---|---|
Antifolate resistance and its circumvention by new analogues.
Topics: Carrier Proteins; Drug Resistance, Neoplasm; Folate Receptors, GPI-Anchored; Folic Acid Antagonists; | 2001 |
1 trial available for trimetrexate and Leucocythaemia
| Article | Year |
|---|---|
A phase I trial of trimetrexate (NSC352122) on a daily x 5 schedule in patients with refractory adult leukemia.
Topics: Adult; Chromatography, High Pressure Liquid; Drug Resistance; Female; Half-Life; Humans; Leukemia; L | 1993 |
10 other studies available for trimetrexate and Leucocythaemia
| Article | Year |
|---|---|
Folate transport and the modulation of antifolate sensitivity in a methotrexate-resistant human breast cancer cell line.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Breast Neoplasms; Carrier Proteins; | 1991 |
Differential alterations of dihydrofolate reductase gene in human leukemia cell lines made resistant to various folate analogues.
Topics: Antineoplastic Agents; Base Sequence; Blotting, Southern; DNA, Neoplasm; Drug Resistance; Folic Acid | 1993 |
A structurally altered human reduced folate carrier with increased folic acid transport mediates a novel mechanism of antifolate resistance.
Topics: Affinity Labels; Biological Transport; Blotting, Northern; Carrier Proteins; Drug Resistance, Neopla | 1998 |
Microsatellite instability and clonal heterogeneity of MDR1 messenger RNA expression in trimetrexate-resistant human leukemia MOLT-3 cells developed in thymidine.
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Drug Resis | 1999 |
Circumvention of methotrexate resistance in childhood leukemia subtypes by rationally designed antifolates.
Topics: Antimetabolites, Antineoplastic; Child; Child, Preschool; Drug Resistance, Neoplasm; Folic Acid Anta | 1999 |
Clustering of mutations in the first transmembrane domain of the human reduced folate carrier in GW1843U89-resistant leukemia cells with impaired antifolate transport and augmented folate uptake.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Blotting, Northern; Blotting, Southern; Blott | 2000 |
Cytotoxicity of methotrexate and trimetrexate and its reversal by folinic acid in human leukemic CCRF-CEM cells with carrier-mediated and receptor-mediated folate uptake.
Topics: Biological Transport; Carrier Proteins; Folate Receptors, GPI-Anchored; Folic Acid; Humans; In Vitro | 1989 |
Multidrug resistance in a human leukemic cell line selected for resistance to trimetrexate.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Doxorubicin; Drug Res | 1989 |
Development of an assay system for the detection and classification of methotrexate resistance in fresh human leukemic cells.
Topics: Adolescent; Adult; Aged; Cell Line; Deoxyuridine; DNA, Neoplasm; Drug Resistance; Female; Humans; Le | 1986 |
Effects of methotrexate and of the "nonclassical" folate antagonist trimetrexate on human leukemia cells.
Topics: Adenocarcinoma; Colonic Neoplasms; DNA Replication; DNA, Neoplasm; Dose-Response Relationship, Drug; | 1987 |