trimetrexate has been researched along with Kidney Neoplasms in 2 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Kidney Neoplasms: Tumors or cancers of the KIDNEY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimetrexate has little activity in advanced renal cell carcinoma at this dose and schedule." | 2.67 | Trimetrexate in advanced renal cell carcinoma. An ECOG phase II trial. ( Bryan, GT; Elson, P; Trump, DL; Witte, RS, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witte, RS | 1 |
| Elson, P | 1 |
| Bryan, GT | 1 |
| Trump, DL | 1 |
| Sternberg, CN | 1 |
| Yagoda, A | 1 |
| Scher, H | 1 |
| Bosl, G | 1 |
| Dershaw, D | 1 |
| Rosado, K | 1 |
| Houston, C | 1 |
| Rosenbluth, R | 1 |
| Vinciguerra, V | 1 |
| Boselli, B | 1 |
1 trial available for trimetrexate and Kidney Neoplasms
| Article | Year |
|---|---|
Trimetrexate in advanced renal cell carcinoma. An ECOG phase II trial.
Topics: Adult; Aged; Carcinoma, Renal Cell; Drug Evaluation; Female; Humans; Kidney Neoplasms; Male; Middle | 1992 |
1 other study available for trimetrexate and Kidney Neoplasms
| Article | Year |
|---|---|
Phase II trial of trimetrexate in patients with advanced renal cell carcinoma. Clinical Community Oncology Program.
Topics: Aged; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Evaluation; Folic Acid Antagonists; Humans; | 1989 |