trimetrexate has been researched along with HIV Coinfection in 3 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The diagnosis of Pneumocystis carinii pneumonia (PCP) rests on the isolation of this micro-organism in patients whose latest blood count, less than 2 months old, shows less than 250 CD4 lymphocytes per cubic mm and who present with signs of impaired lung function." | 2.38 | [Pneumocystis carinii pneumonia in HIV infection. Diagnosis, prognostic factors and curative treatment]. ( Girard, PM; Saimot, AG, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Harris, PJ | 1 |
| Saimot, AG | 1 |
| Girard, PM | 1 |
| Costantino, M | 1 |
1 review available for trimetrexate and HIV Coinfection
| Article | Year |
|---|---|
[Pneumocystis carinii pneumonia in HIV infection. Diagnosis, prognostic factors and curative treatment].
Topics: Adrenal Cortex Hormones; Antineoplastic Agents; CD4-Positive T-Lymphocytes; Dapsone; Eflornithine; F | 1991 |
2 other studies available for trimetrexate and HIV Coinfection
| Article | Year |
|---|---|
Trimetrexate glucuronate associated with anti-Kaposi sarcoma effect.
Topics: Adult; AIDS-Related Opportunistic Infections; Antineoplastic Agents; Drug Combinations; Glucuronates | 1996 |
[Some aspects of the treatment of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Dapsone; HIV Infections; Humans; Primaquine; Trimet | 1991 |