trimetrexate has been researched along with Disease Exacerbation in 5 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two randomised studies were performed with trimetrexate (TMTX) as a biochemical modulator of 5-fluorouracil (5-FU)/leucovorin (LV) in advanced colorectal cancer (ACC), one in Europe and one in the United States." | 9.10 | Integrated analysis of overall survival in two randomised studies comparing 5-fluorouracil/leucovorin with or without trimetrexate in advanced colorectal cancer. ( Blanke, CD; Hammershaimb, L; Punt, CJ; Zhang, J, 2002) |
| "Trimetrexate (TMTX) is a biochemical modulator of 5-fluorouracil (5-FU) and leucovorin (LV)." | 6.70 | Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study. ( Croles, JJ; Douma, J; Hammershaimb, L; Keizer, HJ; Lochs, H; Muller, EW; Punt, CJ; Schüller, J; Skovsgaard, T; Ten Napel, CH; Zhang, J, 2002) |
| "Two randomised studies were performed with trimetrexate (TMTX) as a biochemical modulator of 5-fluorouracil (5-FU)/leucovorin (LV) in advanced colorectal cancer (ACC), one in Europe and one in the United States." | 5.10 | Integrated analysis of overall survival in two randomised studies comparing 5-fluorouracil/leucovorin with or without trimetrexate in advanced colorectal cancer. ( Blanke, CD; Hammershaimb, L; Punt, CJ; Zhang, J, 2002) |
| "Trimetrexate (TMTX) is a biochemical modulator of 5-fluorouracil (5-FU) and leucovorin (LV)." | 2.70 | Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study. ( Croles, JJ; Douma, J; Hammershaimb, L; Keizer, HJ; Lochs, H; Muller, EW; Punt, CJ; Schüller, J; Skovsgaard, T; Ten Napel, CH; Zhang, J, 2002) |
| " The dosage of TMTX was reduced to 8 mg/m(2) daily for 5 days for those who had received prior radiotherapy." | 2.69 | Phase II trial of trimetrexate for patients with advanced gastric carcinoma: an Eastern Cooperative Oncology Group study (E1287). ( Asbury, RF; Greenberg, BR; Haller, DG; Lipsitz, S; Qazi, R; Ramanathan, RK, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 4 (80.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sweeney, CL | 1 |
| Frandsen, JL | 1 |
| Verfaillie, CM | 1 |
| McIvor, RS | 1 |
| Ramanathan, RK | 1 |
| Lipsitz, S | 1 |
| Asbury, RF | 1 |
| Qazi, R | 1 |
| Greenberg, BR | 1 |
| Haller, DG | 1 |
| Blanke, CD | 2 |
| Shultz, J | 1 |
| Cox, J | 1 |
| Modiano, M | 1 |
| Isaacs, R | 1 |
| Kasimis, B | 1 |
| Schilsky, R | 1 |
| Fleagle, J | 1 |
| Moore, M | 1 |
| Kemeny, N | 1 |
| Carlin, D | 1 |
| Hammershaimb, L | 3 |
| Haller, D | 1 |
| Punt, CJ | 2 |
| Keizer, HJ | 1 |
| Douma, J | 1 |
| Skovsgaard, T | 1 |
| Schüller, J | 1 |
| Muller, EW | 1 |
| Ten Napel, CH | 1 |
| Croles, JJ | 1 |
| Lochs, H | 1 |
| Zhang, J | 2 |
4 trials available for trimetrexate and Disease Exacerbation
| Article | Year |
|---|---|
Phase II trial of trimetrexate for patients with advanced gastric carcinoma: an Eastern Cooperative Oncology Group study (E1287).
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Disease Progression; Femal | 1999 |
A double-blind placebo-controlled randomized phase III trial of 5-fluorouracil and leucovorin, plus or minus trimetrexate, in previously untreated patients with advanced colorectal cancer.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorect | 2002 |
Trimetrexate as biochemical modulator of 5-fluorouracil/leucovorin in advanced colorectal cancer: final results of a randomised European study.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms | 2002 |
Integrated analysis of overall survival in two randomised studies comparing 5-fluorouracil/leucovorin with or without trimetrexate in advanced colorectal cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Disease Progression; Female; F | 2002 |
1 other study available for trimetrexate and Disease Exacerbation
| Article | Year |
|---|---|
Trimetrexate inhibits progression of the murine 32Dp210 model of chronic myeloid leukemia in animals expressing drug-resistant dihydrofolate reductase.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Marro | 2003 |