trimetrexate has been researched along with Digestive System Neoplasms in 2 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Digestive System Neoplasms: Tumors or cancer of the DIGESTIVE SYSTEM.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimetrexate (TMTX) is a dihydrofolate reductase inhibitor, which, like methotrexate (MTX), has been shown to potentiate fluorouracil (FU) cytotoxicity by increasing phosphoribosylpyrophosphate (PRPP) levels." | 2.67 | Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma. ( André, M; Bertino, JR; Conti, JA; Goker, E; Kemeny, N; Ragusa, K; Seiter, K; Tong, W, 1994) |
| " The dosage schedule was single-dose intravenous administration (single treatment), followed by one or two courses of 5-day intravenous administration (5-day treatment) at 3-week intervals." | 2.67 | [Phase I study of CI-898. CI-898 Study Group]. ( Ariyoshi, H; Furue, H; Hasegawa, K; Majima, H; Nakao, I; Niitani, H; Ohta, K; Taguchi, T; Tsukagoshi, S; Yasutomi, M, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Conti, JA | 1 |
| Kemeny, N | 1 |
| Seiter, K | 1 |
| Goker, E | 1 |
| Tong, W | 1 |
| André, M | 1 |
| Ragusa, K | 1 |
| Bertino, JR | 1 |
| Taguchi, T | 1 |
| Tsukagoshi, S | 1 |
| Furue, H | 1 |
| Niitani, H | 1 |
| Ohta, K | 1 |
| Ariyoshi, H | 1 |
| Hasegawa, K | 1 |
| Majima, H | 1 |
| Nakao, I | 1 |
| Yasutomi, M | 1 |
2 trials available for trimetrexate and Digestive System Neoplasms
| Article | Year |
|---|---|
Trial of sequential trimetrexate, fluorouracil, and high-dose leucovorin in previously treated patients with gastrointestinal carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Digestive System | 1994 |
[Phase I study of CI-898. CI-898 Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Digestive System Neoplasms; Drug Administratio | 1991 |