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trimetrexate and Carcinoma, Small Cell

trimetrexate has been researched along with Carcinoma, Small Cell in 1 studies

Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.

Carcinoma, Small Cell: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Robson, C1
Wright, KA1
Twentyman, PR1
Lambert, PA1
Griffin, RJ1

Other Studies

1 other study available for trimetrexate and Carcinoma, Small Cell

ArticleYear
Chemical synthesis and biological properties of novel fluorescent antifolates in Pgp- and MRP-overexpressing tumour cell lines.
    Biochemical pharmacology, 1998, Oct-01, Volume: 56, Issue:7

    Topics: 4-Chloro-7-nitrobenzofurazan; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B,

1998