trimetrexate has been researched along with Cancer of Prostate in 2 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "TMTX has modest activity in prostatic cancer, and further trials are not warranted." | 1.28 | Trimetrexate in prostatic cancer: preliminary observations on the use of prostate-specific antigen and acid phosphatase as a marker in measurable hormone-refractory disease. ( Bezirdjian, L; Curley, T; Dershaw, DD; Engstrom, C; Fitzpatrick, K; Geller, N; Lin, SY; Nisselbaum, J; Scher, HI; Schwartz, M, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Witte, RS | 1 |
| Yeap, BY | 1 |
| Trump, DL | 1 |
| Scher, HI | 1 |
| Curley, T | 1 |
| Geller, N | 1 |
| Engstrom, C | 1 |
| Dershaw, DD | 1 |
| Lin, SY | 1 |
| Fitzpatrick, K | 1 |
| Nisselbaum, J | 1 |
| Schwartz, M | 1 |
| Bezirdjian, L | 1 |
1 trial available for trimetrexate and Cancer of Prostate
| Article | Year |
|---|---|
Trimetrexate in advanced hormone-refractory prostate cancer. An ECOG phase II trial.
Topics: Aged; Anemia; Humans; Leukopenia; Male; Middle Aged; Prostatic Neoplasms; Thrombocytopenia; Treatmen | 1994 |
1 other study available for trimetrexate and Cancer of Prostate
| Article | Year |
|---|---|
Trimetrexate in prostatic cancer: preliminary observations on the use of prostate-specific antigen and acid phosphatase as a marker in measurable hormone-refractory disease.
Topics: Acid Phosphatase; Aged; Antigens, Neoplasm; Antineoplastic Agents; Biomarkers, Tumor; Humans; Male; | 1990 |