trimetrexate has been researched along with Body Weight in 2 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimetrexate was administered to rats in an interrupted treatment regimen comparable to proposed human clinical treatment." | 1.28 | Chronic toxicity of the anticancer agent trimetrexate in rats. ( Dethloff, LA; Watkins, JR, 1992) |
| "Trimetrexate is a nonclassical folate antagonist that is active against a number of experimental murine and human tumor cell lines." | 1.28 | Toxicity of the anticancer folate antagonist trimetrexate in rats. ( Graziano, MJ; Kim, SN; MacDonald, JR; Watkins, JR, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dethloff, LA | 1 |
| Watkins, JR | 2 |
| Graziano, MJ | 1 |
| Kim, SN | 1 |
| MacDonald, JR | 1 |
2 other studies available for trimetrexate and Body Weight
| Article | Year |
|---|---|
Chronic toxicity of the anticancer agent trimetrexate in rats.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Cecum; Dose-Response Relationship, Drug; Drug | 1992 |
Toxicity of the anticancer folate antagonist trimetrexate in rats.
Topics: Administration, Oral; Animals; Blood Cell Count; Body Weight; Bone Marrow; Bone Marrow Diseases; Eat | 1992 |