trimetrexate has been researched along with Acquired Immune Deficiency Syndrome in 21 studies
Trimetrexate: A nonclassical folic acid inhibitor through its inhibition of the enzyme dihydrofolate reductase. It is being tested for efficacy as an antineoplastic agent and as an antiparasitic agent against PNEUMOCYSTIS PNEUMONIA in AIDS patients. Myelosuppression is its dose-limiting toxic effect.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome." | 7.67 | Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome. ( Allegra, CJ; Balis, FM; Chabner, BA; Drake, JC; Lane, HC; Masur, H; Murphy, RF; Parrillo, JE; Poplack, DG; Rogers, P, 1988) |
| "The combination of the lipophilic antifolate trimetrexate and the rescue agent leucovorin has shown promise in the treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome." | 3.67 | Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome. ( Allegra, CJ; Balis, FM; Chabner, BA; Drake, JC; Lane, HC; Masur, H; Murphy, RF; Parrillo, JE; Poplack, DG; Rogers, P, 1988) |
| " Pharmacokinetic data and clinical trials are reviewed, as well as adverse effects, drug interactions, and dosage guidelines." | 2.38 | Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS. ( Amsden, GW; Kowalsky, SF; Morse, GD, 1992) |
| "To determine the maximal tolerable dosage of trimetrexate for treatment of pneumocystis pneumonia, 25 patients were treated each day with 45 mg/m2 of trimetrexate and 80 mg/m2 of leucovorin; 10 received 60 mg/m2 and 80 mg/m2; 12 received 60 mg/m2 and 160 mg/m2; and 6 received 90 mg/m2 and 160 mg/m2, respectively." | 1.28 | Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia. ( Akil, B; Allegra, CJ; Feinberg, J; Hughlett, C; Lane, HC; Ogata-Arakaki, D; Sattler, FR; Shelhamer, J; Tuazon, CU; Verdegem, TD, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (57.14) | 18.7374 |
| 1990's | 9 (42.86) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Masur, H | 5 |
| Polis, MA | 1 |
| Tuazon, CU | 4 |
| Ogata-Arakaki, D | 4 |
| Kovacs, JA | 2 |
| Katz, D | 1 |
| Hilt, D | 1 |
| Simmons, T | 1 |
| Feuerstein, I | 1 |
| Lundgren, B | 1 |
| Nusbaum, NJ | 1 |
| Abraham, T | 1 |
| Amsden, GW | 1 |
| Kowalsky, SF | 1 |
| Morse, GD | 1 |
| Vinogradov, NA | 1 |
| Costantino, M | 1 |
| Sattler, FR | 1 |
| Allegra, CJ | 4 |
| Verdegem, TD | 1 |
| Akil, B | 1 |
| Hughlett, C | 1 |
| Feinberg, J | 1 |
| Shelhamer, J | 1 |
| Lane, HC | 2 |
| Davey, RT | 1 |
| Faber, HJ | 1 |
| Sprenger, HG | 1 |
| Weits, J | 1 |
| Montgomery, AB | 1 |
| Hughes, WT | 1 |
| Chabner, BA | 3 |
| Baird, B | 2 |
| Drake, JC | 3 |
| Simmons, JT | 1 |
| Lack, EE | 1 |
| Shelhamer, JH | 1 |
| Balis, F | 1 |
| Rogers, P | 1 |
| Murphy, RF | 1 |
| Poplack, DG | 1 |
| Parrillo, JE | 1 |
| Balis, FM | 1 |
| Fischl, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Randomized, Comparative Trial of Trimetrexate With Leucovorin Rescue Versus Standard Anti-Pneumocystis Therapy Versus Standard Anti-Pneumocystis Therapy With High Dose Steroids for AIDS Patients With Pneumocystis Pneumonia Who Appear to Be Refractory to[NCT00000730] | Phase 3 | 240 participants | Interventional | Terminated | |||
| Evaluation of Escalating Doses of Intravenous Trimetrexate as Therapy for Previously Untreated Pneumocystis Carinii Pneumonia in AIDS Patients With Subsequent Comparison of Intravenous and Oral Pharmacokinetics[NCT00000998] | Phase 1 | 50 participants | Interventional | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for trimetrexate and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Trimetrexate for Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Humans; Pneumonia, Pneumocystis; Trimethoprim, Sulfamethoxazole | 1992 |
[Diagnosis and treatment of Pneumocystis carinii pneumonia in patients with acquired immunodeficiency syndrome].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Diagnosis, Differential; Humans; Pneumonia, Pneumoc | 1991 |
Recent advances in the diagnosis, treatment, and prevention of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Antineoplastic Agents; Humans; Opportunistic Infections; Pneumon | 1990 |
Recent developments in the therapy and management of Pneumocystis carinii pneumonia in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Therapy, Combination; Humans; Pentamidine; Pneumon | 1989 |
Pneumocystis carinii pneumonia: therapy and prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Anti-Bacterial Agents; Dapsone; Drug Combinations; Drug Therapy, | 1988 |
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Antiprotozoal Agents; Clinical Trials a | 1988 |
1 trial available for trimetrexate and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Treatment and prophylaxis of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Antiprotozoal Agents; Clinical Trials a | 1988 |
15 other studies available for trimetrexate and Acquired Immune Deficiency Syndrome
| Article | Year |
|---|---|
Drugs for AIDS and associated infections.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Amphotericin B; Antifunga | 1995 |
Salvage trial of trimetrexate-leucovorin for the treatment of cerebral toxoplasmosis in patients with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Drug Evaluation; Female; Humans; Leucovorin; | 1993 |
AZT modulation of trimetrexate myelotoxicity: evidence from an HL60 model.
Topics: Acquired Immunodeficiency Syndrome; Humans; Leukemia, Myeloid; Models, Biological; Trimetrexate; Tum | 1995 |
[Some aspects of the treatment of HIV infection].
Topics: Acquired Immunodeficiency Syndrome; Clindamycin; Dapsone; HIV Infections; Humans; Primaquine; Trimet | 1991 |
Trimetrexate-leucovorin dosage evaluation study for treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Adult; Dose-Response Relationship, Drug; Drug Evaluation; Drug T | 1990 |
Relapse Pneumocystis carinii pneumonitis and adverse reaction to current therapy in patients with AIDS: trimetrexate as an alternative.
Topics: Acquired Immunodeficiency Syndrome; Adult; Folic Acid Antagonists; Humans; Male; Pneumonia, Pneumocy | 1990 |
AIDS drug available.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Glucuronates; Humans; Pneumonia, Pneumocystis | 1988 |
Trimetrexate for Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Leukopenia; Pneum | 1989 |
Pneumocystis carinii pneumonitis.
Topics: Acquired Immunodeficiency Syndrome; Drug Therapy, Combination; Humans; Leucovorin; Pneumonia, Pneumo | 1987 |
Trimetrexate for the treatment of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Evaluation; Drug Therapy, Combination; Female; Folic | 1987 |
Treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; Dapsone; Drug Combinations; Folic Acid Antagonists; Humans; Meth | 1987 |
Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Administration, Oral; Adult; Biological Availability; Chromatogr | 1988 |
Treatment of Pneumocystis carinii pneumonia with trimetrexate in acquired immunodeficiency syndrome (AIDS).
Topics: Acquired Immunodeficiency Syndrome; Adult; Antineoplastic Agents; Female; Humans; Male; Middle Aged; | 1988 |
[AIDS. Trimetrexate--alternative in Pneumocystis carinii pneumonia].
Topics: Acquired Immunodeficiency Syndrome; Humans; Opportunistic Infections; Pneumonia, Pneumocystis; Quina | 1988 |
FDA bends rules on experimental AIDS drug.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Glucuronates; Health Policy; Humans; Public H | 1988 |