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trimethyloxamine and TDP-43 Proteinopathies

trimethyloxamine has been researched along with TDP-43 Proteinopathies in 1 studies

trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.

TDP-43 Proteinopathies: Diseases characterized by the presence of abnormally phosphorylated, ubiquitinated, and cleaved DNA-binding protein TDP-43 in affected brain and spinal cord. Inclusions of the pathologic protein in neurons and glia, without the presence of AMYLOID, is the major feature of these conditions, thus making these proteinopathies distinct from most other neurogenerative disorders in which protein misfolding leads to brain amyloidosis. Both frontotemporal lobar degeneration and AMYOTROPHIC LATERAL SCLEROSIS exhibit this common method of pathogenesis and thus they may represent two extremes of a continuous clinicopathological spectrum of one disease.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Choi, KJ1
Tsoi, PS1
Moosa, MM1
Paulucci-Holthauzen, A1
Liao, SJ1
Ferreon, JC1
Ferreon, ACM1

Other Studies

1 other study available for trimethyloxamine and TDP-43 Proteinopathies

ArticleYear
A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation.
    Biochemistry, 2018, 12-18, Volume: 57, Issue:50

    Topics: Cytoplasmic Granules; DNA-Binding Proteins; Humans; Intrinsically Disordered Proteins; Liquid-Liquid

2018