trimethyloxamine has been researched along with Pregnancy in 17 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Resveratrol, a phytochemical, has shown antioxidant properties and potential benefits in hypertension." | 8.02 | Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide. ( Chan, JYH; Chang-Chien, GP; Hou, CY; Hsu, CN; Lee, CT; Lin, S; Tain, YL, 2021) |
| "Alterations of gut metabolites, such as SCFAs and trimethylamine (TMA), and microbial composition are associated with the development of hypertension." | 7.91 | Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2019) |
| "Offspring hypertension is associated with increases in the plasma TMAO concentration and oxidative stress and shifts in gut microbiota." | 5.91 | Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Resveratrol, a phytochemical, has shown antioxidant properties and potential benefits in hypertension." | 4.02 | Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide. ( Chan, JYH; Chang-Chien, GP; Hou, CY; Hsu, CN; Lee, CT; Lin, S; Tain, YL, 2021) |
| "Alterations of gut metabolites, such as SCFAs and trimethylamine (TMA), and microbial composition are associated with the development of hypertension." | 3.91 | Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2019) |
| "Choline deficiency during pregnancy can lead to adverse birth outcomes, including impaired neurodevelopment and birth defects." | 3.81 | Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations. ( Berger, H; Caudill, MA; Croxford, R; El-Sohemy, A; Kim, YI; Lausman, AY; Ly, A; Malysheva, O; Masih, S; Nielsen, DE; O'Connor, DL; Plumptre, L; Sohn, KJ; Visentin, CE, 2015) |
| "Offspring hypertension is associated with increases in the plasma TMAO concentration and oxidative stress and shifts in gut microbiota." | 1.91 | Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Triclosan is a broad-spectrum antimicrobial, and was thought to affect intrauterine development, but the mechanism remains unclear." | 1.72 | Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes. ( Cao, Y; Chang, X; Dai, Y; Guo, J; Liang, W; Lu, D; Lv, S; Qi, X; Wang, Z; Wu, C; Zhang, J; Zhang, L; Zhou, Z, 2022) |
| "Birth weight was higher in the G allele homozygotes of the CHDH rs2289205 than in the minor allele carriers: GG: 3398 ± 64 g; GA+AA: 3193 ± 76 g." | 1.48 | PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women. ( Barlik, M; Chmurzynska, A; Drews, K; Jagodziński, PP; Kurzawińska, G; Malinowska, AM; Radziejewska, A; Różycka, A; Seremak-Mrozikiewicz, A; Szwengiel, A, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 10 (58.82) | 24.3611 |
| 2020's | 7 (41.18) | 2.80 |
| Authors | Studies |
|---|---|
| Jääskeläinen, T | 1 |
| Kärkkäinen, O | 1 |
| Heinonen, S | 1 |
| Hanhineva, K | 1 |
| Laivuori, H | 1 |
| Zhang, J | 1 |
| Wang, Z | 1 |
| Dai, Y | 1 |
| Zhang, L | 1 |
| Guo, J | 1 |
| Lv, S | 1 |
| Qi, X | 1 |
| Lu, D | 1 |
| Liang, W | 1 |
| Cao, Y | 1 |
| Wu, C | 2 |
| Chang, X | 1 |
| Zhou, Z | 1 |
| Tain, YL | 3 |
| Chang-Chien, GP | 3 |
| Lin, S | 3 |
| Hou, CY | 3 |
| Hsu, CN | 3 |
| Wang, J | 1 |
| Gu, X | 1 |
| Yang, J | 1 |
| Wei, Y | 1 |
| Zhao, Y | 1 |
| Nagy, RA | 1 |
| Homminga, I | 1 |
| Jia, C | 1 |
| Liu, F | 1 |
| Anderson, JLC | 1 |
| Hoek, A | 1 |
| Tietge, UJF | 1 |
| Chang, QX | 1 |
| Chen, X | 2 |
| Zang, NL | 1 |
| Li, LQ | 1 |
| Zhong, N | 1 |
| Xia, LX | 1 |
| Huang, QT | 1 |
| Zhong, M | 2 |
| Chan, JYH | 1 |
| Lee, CT | 1 |
| Lin, X | 1 |
| Zhang, Y | 1 |
| He, X | 1 |
| Chen, Y | 1 |
| Chen, N | 1 |
| Liu, J | 2 |
| Wang, M | 1 |
| Li, Y | 1 |
| Yang, H | 1 |
| Fan, L | 1 |
| Hou, Y | 1 |
| Li, J | 3 |
| Qi, H | 1 |
| Zhang, H | 1 |
| Xiao, X | 1 |
| Trenteseaux, C | 1 |
| Gaston, AT | 1 |
| Aguesse, A | 1 |
| Poupeau, G | 1 |
| de Coppet, P | 1 |
| Andriantsitohaina, R | 1 |
| Laschet, J | 1 |
| Amarger, V | 1 |
| Krempf, M | 1 |
| Nobecourt-Dupuy, E | 1 |
| Ouguerram, K | 1 |
| Chmurzynska, A | 2 |
| Mlodzik, MA | 1 |
| Radziejewska, A | 2 |
| Szwengiel, A | 2 |
| Malinowska, AM | 2 |
| Nowacka-Woszuk, J | 1 |
| Seremak-Mrozikiewicz, A | 1 |
| Różycka, A | 1 |
| Kurzawińska, G | 1 |
| Barlik, M | 1 |
| Jagodziński, PP | 1 |
| Drews, K | 1 |
| Li, P | 1 |
| Zhong, C | 1 |
| Li, S | 1 |
| Sun, T | 1 |
| Huang, H | 1 |
| Zhu, Y | 1 |
| Hu, X | 1 |
| Peng, X | 1 |
| Zhang, X | 1 |
| Bao, W | 1 |
| Shan, Z | 1 |
| Cheng, J | 1 |
| Hu, FB | 1 |
| Yang, N | 1 |
| Liu, L | 1 |
| Chen, H | 1 |
| Li, N | 1 |
| Liu, H | 1 |
| Tang, J | 1 |
| Wen, Y | 1 |
| Peng, L | 1 |
| Xu, R | 1 |
| Zang, N | 1 |
| Huang, Q | 1 |
| Huo, X | 1 |
| Cao, YF | 1 |
| Li, SN | 1 |
| Shao, P | 1 |
| Leng, J | 1 |
| Li, W | 1 |
| Yang, K | 1 |
| Ma, RCW | 1 |
| Hu, G | 1 |
| Fang, ZZ | 1 |
| Yang, X | 1 |
| Visentin, CE | 1 |
| Masih, S | 1 |
| Plumptre, L | 1 |
| Malysheva, O | 1 |
| Nielsen, DE | 1 |
| Sohn, KJ | 1 |
| Ly, A | 1 |
| Lausman, AY | 1 |
| Berger, H | 1 |
| Croxford, R | 1 |
| El-Sohemy, A | 1 |
| Caudill, MA | 1 |
| O'Connor, DL | 1 |
| Kim, YI | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Between Trimethylamine-N-oxide Levels and Risk of Gestational Diabetes Mellitus[NCT03415295] | 1,694 participants (Actual) | Observational | 2012-08-01 | Completed | |||
| [NCT02244684] | 368 participants (Actual) | Observational | 2010-09-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
17 other studies available for trimethyloxamine and Pregnancy
| Article | Year |
|---|---|
No association in maternal serum levels of TMAO and its precursors in pre-eclampsia and in non-complicated pregnancies.
Topics: Animals; Biomarkers; Case-Control Studies; Female; Humans; Methylamines; Pre-Eclampsia; Pregnancy; R | 2022 |
Multiple mediation effects on association between prenatal triclosan exposure and birth outcomes.
Topics: Acetylcarnitine; Bayes Theorem; Betaine; Choline; Cohort Studies; Estradiol; Female; Humans; Leptin; | 2022 |
Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension.
Topics: Animals; Female; Humans; Hypertension; Hypertrophy; Methylamines; Oxides; Pregnancy; Rats; Renal Ins | 2023 |
Gut Microbiota Dysbiosis and Increased Plasma LPS and TMAO Levels in Patients With Preeclampsia.
Topics: Adult; Biomarkers; Case-Control Studies; Dysbiosis; Feces; Female; Gastrointestinal Microbiome; Huma | 2019 |
Trimethylamine-N-oxide is present in human follicular fluid and is a negative predictor of embryo quality.
Topics: Cross-Sectional Studies; Female; Fertilization in Vitro; Follicular Fluid; Humans; Methylamines; Net | 2020 |
Trimethylamine N-Oxide increases soluble fms-like tyrosine Kinase-1 in human placenta via NADPH oxidase dependent ROS accumulation.
Topics: Cells, Cultured; Female; Gene Expression Regulation; Humans; Methylamines; NADPH Oxidases; Oxidation | 2021 |
Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide.
Topics: Animals; Antioxidants; Arginine; Female; Gastrointestinal Microbiome; Hypertension; Methylamines; Pr | 2021 |
The Choline Metabolite TMAO Inhibits NETosis and Promotes Placental Development in GDM of Humans and Mice.
Topics: Adult; Animals; Case-Control Studies; Cells, Cultured; Choline; Diabetes, Gestational; Extracellular | 2021 |
Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.
Topics: Age Factors; Animals; Animals, Newborn; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; | 2017 |
Caloric restriction can affect one-carbon metabolism during pregnancy in the rat: A transgenerational model.
Topics: Animals; Betaine; Caloric Restriction; Carbon; Choline; DNA Methylation; Female; Gene Expression; Ho | 2018 |
PEMT rs12325817 and PCYT1A rs7639752 polymorphisms are associated with betaine but not choline concentrations in pregnant women.
Topics: Adolescent; Adult; Alleles; Betaine; Birth Weight; Carnitine; Choline; Choline-Phosphate Cytidylyltr | 2018 |
Plasma concentration of trimethylamine-N-oxide and risk of gestational diabetes mellitus.
Topics: Adult; Case-Control Studies; Cohort Studies; Diabetes, Gestational; Fasting; Female; Gestational Age | 2018 |
Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Female; Hexanols; Inflammation; Interleukin- | 2019 |
Maternal serum trimethylamine-N-oxide is significantly increased in cases with established preeclampsia.
Topics: Adult; Biomarkers; Case-Control Studies; Female; Humans; Interleukin-1beta; Methylamines; Pre-Eclamp | 2019 |
Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring.
Topics: Acetates; Animals; Blood Pressure; Dietary Supplements; Fatty Acids, Volatile; Female; Fructose; Gas | 2019 |
Trimethylamine N-Oxide Metabolites in Early Pregnancy and Risk of Gestational Diabetes: A Nested Case-Control Study.
Topics: Adult; Betaine; Blood Glucose; Carnitine; Case-Control Studies; China; Choline; Diabetes, Gestationa | 2019 |
Maternal Choline Status, but Not Fetal Genotype, Influences Cord Plasma Choline Metabolite Concentrations.
Topics: Adolescent; Adult; Betaine; Canada; Choline; Female; Fetal Blood; Fetus; Genotype; Healthy Volunteer | 2015 |