Page last updated: 2024-10-20

trimethyloxamine and Ischemic Stroke

trimethyloxamine has been researched along with Ischemic Stroke in 14 studies

trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.

Ischemic Stroke: Stroke due to BRAIN ISCHEMIA resulting in interruption or reduction of blood flow to a part of the brain. When obstruction is due to a BLOOD CLOT formed within in a cerebral blood vessel it is a thrombotic stroke. When obstruction is formed elsewhere and moved to block a cerebral blood vessel (see CEREBRAL EMBOLISM) it is referred to as embolic stroke. Wake-up stroke refers to ischemic stroke occurring during sleep while cryptogenic stroke refers to ischemic stroke of unknown origin.

Research Excerpts

ExcerptRelevanceReference
"Although trimethylamine-N-oxide (TMAO) shows a notable correlation with cardiovascular disease, its association with acute ischemic stroke (AIS) remains uncertain and necessitates further investigation."9.41The relationship between trimethylamine-N-oxide and the risk of acute ischemic stroke: A dose‒response meta-analysis. ( Duan, Y; Guo, Z; Hong, Y; Li, Y; Liu, N; Sun, Z; Xu, Q; Yang, K, 2023)
"Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment."9.41Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021)
"Although trimethylamine-N-oxide (TMAO) shows a notable correlation with cardiovascular disease, its association with acute ischemic stroke (AIS) remains uncertain and necessitates further investigation."5.41The relationship between trimethylamine-N-oxide and the risk of acute ischemic stroke: A dose‒response meta-analysis. ( Duan, Y; Guo, Z; Hong, Y; Li, Y; Liu, N; Sun, Z; Xu, Q; Yang, K, 2023)
"Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment."5.41Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021)
"Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population."4.12Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022)
"A total of 64 patients with acute ischemic stroke were randomized into an observation group and a control group, 32 cases in each one."3.11[ ( Du, XZ; Lei, SQ; Liu, MK; Wang, H; Yuan, B, 2022)
"As we know, ischemic stroke is a heterogeneous disease with variable pathogenesis."2.82Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes. ( Cheng, A; Dai, L; Jing, J; Li, H; Meng, X; Song, B; Wang, A; Wang, Y; Xu, J; Xue, J; Zhao, M; Zheng, L, 2022)
" Trimethylamine N-oxide level, Acute ischemic stroke, Early neurological deterioration, NIHSS score."1.91Utility of Trimethylamine Oxide (TMAO) in Predicting Early Neurological Deterioration after Acute Ischemic Stroke. ( Cheng, H; Kang, Y; Liu, J; Shi, Y; Wan, D; Wang, Y, 2023)
"TMAO was associated with lacunar stroke but not other ischemic stroke subtypes in a model adjusted for age, sex, hypertension, diabetes, and smoking (OR, 1."1.91Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke. ( Ament, Z; Bevers, MB; Bhave, VM; Couch, CA; Garcia Guarniz, AL; Irvin, MR; Kijpaisalratana, N; Kimberly, WT, 2023)
"A total of 196 patients with ischaemic stroke and 100 controls were included between February 2018 and April 2019."1.56Trimethylamine-N-oxide is elevated in the acute phase after ischaemic stroke and decreases within the first days. ( Hauke, J; Mundiyanapurath, S; Nürnberg, C; Okun, JG; Ringleb, PA; Schneider, C; Schwarz, KV; Ungerer, M; Zorn, M, 2020)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's14 (100.00)2.80

Authors

AuthorsStudies
Xu, J1
Cheng, A1
Song, B1
Zhao, M1
Xue, J1
Wang, A2
Dai, L1
Jing, J1
Meng, X1
Li, H1
Zheng, L1
Wang, Y2
Wang, H1
Lei, SQ1
Du, XZ1
Yuan, B1
Liu, MK1
Chen, C1
Qiao, X1
Guo, J1
Yang, T1
Wang, M1
Ma, Y1
Zhao, S1
Ding, L1
Liu, H1
Wang, J1
Chou, PS1
Yang, IH1
Kuo, CM1
Wu, MN1
Lin, TC1
Fong, YO1
Juan, CH1
Lai, CL1
Kang, Y1
Cheng, H1
Shi, Y1
Liu, J1
Wan, D1
Lemaitre, RN1
Jensen, PN1
Wang, Z1
Fretts, AM1
Sitlani, CM1
Nemet, I1
Sotoodehnia, N1
de Oliveira Otto, MC1
Zhu, W1
Budoff, M1
Longstreth, WT1
Psaty, BM1
Siscovick, DS1
Hazen, SL1
Mozaffarian, D1
Kijpaisalratana, N1
Ament, Z1
Bevers, MB1
Bhave, VM1
Garcia Guarniz, AL1
Couch, CA1
Irvin, MR1
Kimberly, WT1
Hong, Y1
Sun, Z1
Liu, N1
Yang, K1
Li, Y1
Xu, Q1
Guo, Z1
Duan, Y1
Hu, X1
Ren, H1
Cao, Y1
Schneider, C1
Okun, JG1
Schwarz, KV1
Hauke, J1
Zorn, M1
Nürnberg, C1
Ungerer, M1
Ringleb, PA1
Mundiyanapurath, S1
Sun, T1
Zhang, Y2
Yin, J1
Peng, X1
Zhou, L1
Huang, S1
Wen, Y1
Cao, B1
Chen, L1
Li, X1
Yang, W1
Tan, A1
Cheng, J1
Liu, L1
Yamashita, T1
Yoshida, N1
Emoto, T1
Hirata, KI1
Zhong, C1
Lu, Z1
Che, B1
Qian, S1
Zheng, X1
Bu, X1
Zhang, J2
Ju, Z1
Xu, T1
Wang, L1
Cai, J1
Lei, A1
Liu, C1
Lin, R1
Jia, L1
Fu, Y1

Reviews

3 reviews available for trimethyloxamine and Ischemic Stroke

ArticleYear
Trimethylamine N-Oxide and Stroke Recurrence Depends on Ischemic Stroke Subtypes.
    Stroke, 2022, Volume: 53, Issue:4

    Topics: Atherosclerosis; Humans; Ischemic Stroke; Methylamines; Risk Factors; Stroke

2022
The relationship between trimethylamine-N-oxide and the risk of acute ischemic stroke: A dose‒response meta-analysis.
    PloS one, 2023, Volume: 18, Issue:10

    Topics: Humans; Ischemic Stroke; Methylamines; Oxides; Stroke

2023
The association between trimethylamine N-oxide levels and ischemic stroke occurrence: a meta-analysis and Mendelian randomization study.
    BMC neurology, 2023, Nov-21, Volume: 23, Issue:1

    Topics: Genome-Wide Association Study; Humans; Ischemic Stroke; Mendelian Randomization Analysis; Methylamin

2023

Trials

3 trials available for trimethyloxamine and Ischemic Stroke

ArticleYear
[
    Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2022, Aug-12, Volume: 42, Issue:8

    Topics: Acupuncture Points; Acupuncture Therapy; Brain-Gut Axis; C-Reactive Protein; Humans; Interleukin-17;

2022
Plasma Trimethylamine-
    Journal of the American Heart Association, 2023, 08-15, Volume: 12, Issue:16

    Topics: Aged; Atherosclerosis; Female; Humans; Ischemic Stroke; Methylamines; Oxides; Prospective Studies; R

2023
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
    Stroke, 2021, Volume: 52, Issue:3

    Topics: Aged; Antihypertensive Agents; Brain Ischemia; China; Choline; Cognition; Cognition Disorders; Cogni

2021

Other Studies

8 other studies available for trimethyloxamine and Ischemic Stroke

ArticleYear
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
    Frontiers in endocrinology, 2022, Volume: 13

    Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I

2022
The Prognostic Biomarkers of Plasma Trimethylamine N-Oxide and Short-Chain Fatty Acids for Recanalization Therapy in Acute Ischemic Stroke.
    International journal of molecular sciences, 2023, Jun-28, Volume: 24, Issue:13

    Topics: Adult; Biomarkers; Brain Ischemia; Fatty Acids, Volatile; Humans; Ischemic Stroke; Prognosis; Prospe

2023
Utility of Trimethylamine Oxide (TMAO) in Predicting Early Neurological Deterioration after Acute Ischemic Stroke.
    Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 2023, Volume: 33, Issue:8

    Topics: Biomarkers; Brain Ischemia; Cohort Studies; Humans; Ischemic Stroke; Stroke; United States

2023
Trimethylamine N-Oxide and White Matter Hyperintensity Volume Among Patients With Acute Ischemic Stroke.
    JAMA network open, 2023, 08-01, Volume: 6, Issue:8

    Topics: Aged; Betaine; Carnitine; Cerebral Small Vessel Diseases; Choline; Cross-Sectional Studies; Female;

2023
Trimethylamine-N-oxide is elevated in the acute phase after ischaemic stroke and decreases within the first days.
    European journal of neurology, 2020, Volume: 27, Issue:8

    Topics: Brain Ischemia; Case-Control Studies; Humans; Ischemic Stroke; Methylamines; Oxides; Prospective Stu

2020
Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke.
    Journal of atherosclerosis and thrombosis, 2021, Apr-01, Volume: 28, Issue:4

    Topics: Age Factors; Alcohol Drinking; Body Mass Index; Case-Control Studies; China; Chromatography, Liquid;

2021
Unraveling the Effects of Trimethylamine N-Oxide on Stroke: "The lower, the better?"
    Journal of atherosclerosis and thrombosis, 2021, Apr-01, Volume: 28, Issue:4

    Topics: Betaine; Carnitine; Cholesterol; Choline; Diet Therapy; Gastrointestinal Microbiome; Humans; Ischemi

2021
Gut microbial metabolite TMAO portends prognosis in acute ischemic stroke.
    Journal of neuroimmunology, 2021, 05-15, Volume: 354

    Topics: Aged; Biomarkers; China; Choline; Cohort Studies; Female; Gastrointestinal Microbiome; Humans; Ische

2021