trimethyloxamine has been researched along with Hypertension in 29 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment." | 9.41 | Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021) |
| "The association of total choline (TC) intake and its metabolite trimethylamine-N-oxide (TMAO) with hypertension and blood pressure (BP) has not been elucidated." | 8.12 | Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension. ( Feng, YQ; He, GD; Liu, XC; Lu, AS, 2022) |
| "Resveratrol, a phytochemical, has shown antioxidant properties and potential benefits in hypertension." | 8.02 | Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide. ( Chan, JYH; Chang-Chien, GP; Hou, CY; Hsu, CN; Lee, CT; Lin, S; Tain, YL, 2021) |
| "Alterations of gut metabolites, such as SCFAs and trimethylamine (TMA), and microbial composition are associated with the development of hypertension." | 7.91 | Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2019) |
| "Offspring hypertension is associated with increases in the plasma TMAO concentration and oxidative stress and shifts in gut microbiota." | 5.91 | Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment." | 5.41 | Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021) |
| "The association of total choline (TC) intake and its metabolite trimethylamine-N-oxide (TMAO) with hypertension and blood pressure (BP) has not been elucidated." | 4.12 | Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension. ( Feng, YQ; He, GD; Liu, XC; Lu, AS, 2022) |
| "Increased levels of lactic acid, pyruvate, and TMAO may be related to the pathophysiological changes in the minor ischaemic stroke population." | 4.12 | Related factors based on non-targeted metabolomics methods in minor ischaemic stroke. ( Chen, C; Ding, L; Guo, J; Liu, H; Ma, Y; Qiao, X; Wang, J; Wang, M; Yang, T; Zhao, S, 2022) |
| "Resveratrol, a phytochemical, has shown antioxidant properties and potential benefits in hypertension." | 4.02 | Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide. ( Chan, JYH; Chang-Chien, GP; Hou, CY; Hsu, CN; Lee, CT; Lin, S; Tain, YL, 2021) |
| "This study assessed the association of choline intake with hypertension and BP in US adults through the use of NHANES 2007-2010 data." | 3.91 | Relation of choline intake with blood pressure in the National Health and Nutrition Examination Survey 2007-2010. ( Cassano, PA; Caudill, MA; Taesuwan, S; Vermeylen, F, 2019) |
| "Alterations of gut metabolites, such as SCFAs and trimethylamine (TMA), and microbial composition are associated with the development of hypertension." | 3.91 | Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2019) |
| "Hypertension is the most prevalent chronic disease and a risk factor for various diseases." | 2.72 | TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies. ( Ding, YJ; Jia, QJ; Li, YY; Lv, SC; Wang, YJ; Zhang, A; Zhang, JP; Zhang, WQ; Zhang, XN; Zhu, YP, 2021) |
| "0001) according to the dose-response meta-analysis." | 2.66 | The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis. ( Fan, H; Ge, X; Liu, G; Xi, X; Xu, Z; Yu, P; Zheng, L; Zhou, X; Zhuang, R, 2020) |
| "Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier, which in turn increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of CVD." | 2.58 | The gut microbiota as a novel regulator of cardiovascular function and disease. ( Battson, ML; Gentile, CL; Lee, DM; Weir, TL, 2018) |
| "Offspring hypertension is associated with increases in the plasma TMAO concentration and oxidative stress and shifts in gut microbiota." | 1.91 | Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension. ( Chang-Chien, GP; Hou, CY; Hsu, CN; Lin, S; Tain, YL, 2023) |
| "Hypertension is an independent and preventable risk factor for the development of cardiovascular diseases, however, little is known about the impact of gut microbiota composition in its development." | 1.56 | Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study. ( Artacho, A; Calderón-Pérez, L; Companys, J; Gosalbes, MJ; Jimenez-Hernandez, N; Llauradó, E; Ludwig, I; Pedret, A; Pla-Pagà, L; Romero, MP; Rubió, L; Solà, R; Valls, RM; Yuste, S, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 10 (34.48) | 24.3611 |
| 2020's | 16 (55.17) | 2.80 |
| Authors | Studies |
|---|---|
| Li, D | 1 |
| Lu, Y | 1 |
| Yuan, S | 1 |
| Cai, X | 1 |
| He, Y | 1 |
| Chen, J | 1 |
| Wu, Q | 1 |
| He, D | 1 |
| Fang, A | 1 |
| Bo, Y | 1 |
| Song, P | 1 |
| Bogaert, D | 1 |
| Tsilidis, K | 1 |
| Larsson, SC | 1 |
| Yu, H | 1 |
| Zhu, H | 1 |
| Theodoratou, E | 1 |
| Zhu, Y | 1 |
| Li, X | 3 |
| He, GD | 1 |
| Liu, XC | 1 |
| Lu, AS | 1 |
| Feng, YQ | 1 |
| Chen, C | 1 |
| Qiao, X | 1 |
| Guo, J | 1 |
| Yang, T | 1 |
| Wang, M | 1 |
| Ma, Y | 1 |
| Zhao, S | 1 |
| Ding, L | 1 |
| Liu, H | 1 |
| Wang, J | 2 |
| Tain, YL | 3 |
| Chang-Chien, GP | 3 |
| Lin, S | 3 |
| Hou, CY | 3 |
| Hsu, CN | 3 |
| Calderón-Pérez, L | 1 |
| Gosalbes, MJ | 1 |
| Yuste, S | 1 |
| Valls, RM | 1 |
| Pedret, A | 1 |
| Llauradó, E | 1 |
| Jimenez-Hernandez, N | 1 |
| Artacho, A | 1 |
| Pla-Pagà, L | 1 |
| Companys, J | 1 |
| Ludwig, I | 1 |
| Romero, MP | 1 |
| Rubió, L | 1 |
| Solà, R | 1 |
| Poll, BG | 1 |
| Cheema, MU | 1 |
| Pluznick, JL | 1 |
| Sun, T | 1 |
| Zhang, Y | 2 |
| Yin, J | 2 |
| Peng, X | 1 |
| Zhou, L | 1 |
| Huang, S | 1 |
| Wen, Y | 1 |
| Cao, B | 1 |
| Chen, L | 1 |
| Yang, W | 1 |
| Tan, A | 1 |
| Cheng, J | 1 |
| Liu, L | 1 |
| Lu, D | 1 |
| Zhang, H | 2 |
| Shan, Q | 1 |
| Zhou, B | 1 |
| Verhaar, BJH | 1 |
| Prodan, A | 1 |
| Nieuwdorp, M | 1 |
| Muller, M | 1 |
| Naqvi, S | 1 |
| Asar, TO | 1 |
| Kumar, V | 1 |
| Al-Abbasi, FA | 1 |
| Alhayyani, S | 1 |
| Kamal, MA | 1 |
| Anwar, F | 1 |
| Duttaroy, AK | 1 |
| Zhong, C | 1 |
| Lu, Z | 1 |
| Che, B | 1 |
| Qian, S | 1 |
| Zheng, X | 1 |
| Wang, A | 1 |
| Bu, X | 1 |
| Zhang, J | 1 |
| Ju, Z | 1 |
| Xu, T | 1 |
| Zhang, WQ | 1 |
| Wang, YJ | 1 |
| Zhang, A | 1 |
| Ding, YJ | 1 |
| Zhang, XN | 1 |
| Jia, QJ | 1 |
| Zhu, YP | 1 |
| Li, YY | 1 |
| Lv, SC | 1 |
| Zhang, JP | 1 |
| Chan, JYH | 1 |
| Lee, CT | 1 |
| Zhou, J | 1 |
| Wang, D | 1 |
| Li, B | 1 |
| Lai, X | 1 |
| Lei, S | 1 |
| Li, N | 1 |
| Zhang, X | 1 |
| Jaworska, K | 1 |
| Huc, T | 2 |
| Samborowska, E | 2 |
| Dobrowolski, L | 1 |
| Bielinska, K | 2 |
| Gawlak, M | 1 |
| Ufnal, M | 3 |
| Battson, ML | 1 |
| Lee, DM | 1 |
| Weir, TL | 1 |
| Gentile, CL | 1 |
| Liu, M | 1 |
| Han, Q | 1 |
| Yang, J | 1 |
| Drapala, A | 2 |
| Gawrys, M | 1 |
| Konop, M | 1 |
| Zaorska, E | 1 |
| Wyczalkowska-Tomasik, A | 1 |
| Pączek, L | 1 |
| Dadlez, M | 2 |
| Nie, J | 1 |
| Xie, L | 1 |
| Zhao, BX | 1 |
| Li, Y | 1 |
| Qiu, B | 1 |
| Zhu, F | 1 |
| Li, GF | 1 |
| He, M | 1 |
| Wang, Y | 1 |
| Wang, B | 1 |
| Liu, S | 1 |
| Guo, H | 1 |
| Cai, Y | 1 |
| Huo, Y | 1 |
| Hou, FF | 1 |
| Xu, X | 1 |
| Qin, X | 1 |
| Jin, M | 1 |
| Qian, Z | 1 |
| Xu, W | 1 |
| Zhou, X | 2 |
| Liu, J | 1 |
| Li, T | 1 |
| Wu, H | 1 |
| Shi, H | 1 |
| Bai, J | 1 |
| Zhao, W | 1 |
| Jiang, D | 1 |
| Jiang, X | 1 |
| Taesuwan, S | 1 |
| Vermeylen, F | 1 |
| Caudill, MA | 1 |
| Cassano, PA | 1 |
| Ge, X | 1 |
| Zheng, L | 1 |
| Zhuang, R | 1 |
| Yu, P | 1 |
| Xu, Z | 1 |
| Liu, G | 1 |
| Xi, X | 1 |
| Fan, H | 1 |
| Jazwiec, R | 1 |
| Sikora, M | 1 |
| Skrzypecki, J | 1 |
| Akira, K | 2 |
| Imachi, M | 2 |
| Hashimoto, T | 2 |
| Fujiwara, M | 1 |
| Arifuku, K | 1 |
| Ando, I | 1 |
| Nemoto, T | 1 |
| Masu, S | 1 |
| Mitome, H | 1 |
| Hashimoto, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.[NCT05795946] | 45 participants (Anticipated) | Interventional | 2023-04-15 | Recruiting | |||
| Enalapril Maleate and Folic Acid Tablets for Primary Prevention of Stroke in Patients With Hypertension: a Post-marketing, Double-blind, Randomized Controlled Trial.[NCT00794885] | Phase 4 | 20,702 participants (Actual) | Interventional | 2008-05-31 | Completed | ||
| Association Analysis of Cardiovascular and Nervous System Diseases and Intestinal Microbiome Based on Multi-omics Big Data and Related Applications[NCT06099496] | 490 participants (Anticipated) | Observational [Patient Registry] | 2023-04-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
9 reviews available for trimethyloxamine and Hypertension
| Article | Year |
|---|---|
Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis.
Topics: Cardiovascular Diseases; Diabetes Mellitus; Gastrointestinal Microbiome; Humans; Hypertension; Methy | 2022 |
Gut Microbial Metabolites and Blood Pressure Regulation: Focus on SCFAs and TMAO.
Topics: Animals; Blood Pressure; Fatty Acids, Volatile; Gastrointestinal Microbiome; Humans; Hypertension; M | 2020 |
Gut Microbiota in Hypertension and Atherosclerosis: A Review.
Topics: Animals; Atherosclerosis; Blood Pressure; Fatty Acids, Volatile; Gastrointestinal Microbiome; Gram-N | 2020 |
A cross-talk between gut microbiome, salt and hypertension.
Topics: Animals; Bacteria; Blood Pressure; Diet, Healthy; Diet, Sodium-Restricted; Dietary Fiber; Dietary Su | 2021 |
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review.
Topics: Animals; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Fatty Acids, Volatile; Gastroint | 2021 |
TMA/TMAO in Hypertension: Novel Horizons and Potential Therapies.
Topics: Animals; Carnitine; Choline; Gastrointestinal Microbiome; Glucose; Humans; Hypertension; Inflammatio | 2021 |
The gut microbiota as a novel regulator of cardiovascular function and disease.
Topics: Aging; Animals; Anti-Bacterial Agents; Atherosclerosis; Bile Acids and Salts; Cardiovascular Disease | 2018 |
The role of intestinal microbiota in cardiovascular disease.
Topics: Bile Acids and Salts; Cardiovascular Diseases; Dysbiosis; Fatty Acids; Gastrointestinal Microbiome; | 2019 |
The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis.
Topics: Adult; Aged; Bacteria; Cardiovascular Diseases; Female; Gastrointestinal Microbiome; Humans; Hyperte | 2020 |
1 trial available for trimethyloxamine and Hypertension
| Article | Year |
|---|---|
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
Topics: Aged; Antihypertensive Agents; Brain Ischemia; China; Choline; Cognition; Cognition Disorders; Cogni | 2021 |
19 other studies available for trimethyloxamine and Hypertension
| Article | Year |
|---|---|
Association of Choline Intake with Blood Pressure and Effects of Its Microbiota-Dependent Metabolite Trimethylamine-N-Oxide on Hypertension.
Topics: Animals; Blood Pressure; Choline; Hypertension; Methylamines; Microbiota; Nutrition Surveys; Oxides; | 2022 |
Related factors based on non-targeted metabolomics methods in minor ischaemic stroke.
Topics: Biomarkers; Blood Glucose; Brain Ischemia; C-Reactive Protein; Homocysteine; Humans; Hypertension; I | 2022 |
Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension.
Topics: Animals; Female; Humans; Hypertension; Hypertrophy; Methylamines; Oxides; Pregnancy; Rats; Renal Ins | 2023 |
Gut metagenomic and short chain fatty acids signature in hypertension: a cross-sectional study.
Topics: Adult; Blood Pressure; Cross-Sectional Studies; DNA, Bacterial; Fatty Acids, Volatile; Feces; Female | 2020 |
Association of Gut Microbiota-Dependent Metabolite Trimethylamine N-Oxide with First Ischemic Stroke.
Topics: Age Factors; Alcohol Drinking; Body Mass Index; Case-Control Studies; China; Chromatography, Liquid; | 2021 |
Renal denervation improves chronic intermittent hypoxia induced hypertension and cardiac fibrosis and balances gut microbiota.
Topics: Animals; Blood Pressure; Cardiomyopathies; Denervation; Disease Models, Animal; Fibrosis; Gastrointe | 2020 |
Maternal resveratrol therapy protected adult rat offspring against hypertension programmed by combined exposures to asymmetric dimethylarginine and trimethylamine-N-oxide.
Topics: Animals; Antioxidants; Arginine; Female; Gastrointestinal Microbiome; Hypertension; Methylamines; Pr | 2021 |
Relationship between Plasma Trimethylamine N-Oxide Levels and Renal Dysfunction in Patients with Hypertension.
Topics: Biomarkers; Cross-Sectional Studies; Female; Humans; Hypertension; Male; Methylamines; Middle Aged; | 2021 |
Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite.
Topics: Animals; Blood Pressure; Colon; Hypertension; Intestinal Mucosa; Male; Methylamines; Rats; Rats, Inb | 2017 |
Trimethylamine-N-oxide (TMAO) increased aquaporin-2 expression in spontaneously hypertensive rats.
Topics: Animals; Antidiuretic Hormone Receptor Antagonists; Aquaporin 2; Blood Pressure; Hypertension; Kidne | 2019 |
Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Fibrosis; Hypertension; Male; Methylamines; Myocar | 2018 |
Serum Trimethylamine N-Oxide Concentration Is Positively Associated With First Stroke in Hypertensive Patients.
Topics: Aged; Carnitine; Case-Control Studies; China; Choline; Female; Folic Acid; Gastrointestinal Microbio | 2018 |
Lactobacillus rhamnosus GG strain mitigated the development of obstructive sleep apnea-induced hypertension in a high salt diet via regulating TMAO level and CD4
Topics: Animals; CD4-Positive T-Lymphocytes; Hypertension; Inflammation; Inflammation Mediators; Lacticaseib | 2019 |
Relation of choline intake with blood pressure in the National Health and Nutrition Examination Survey 2007-2010.
Topics: Adult; Aged; Blood Pressure; Choline; Cross-Sectional Studies; Female; Humans; Hypertension; Male; M | 2019 |
Targeting on Gut Microbial Metabolite Trimethylamine-N-Oxide and Short-Chain Fatty Acid to Prevent Maternal High-Fructose-Diet-Induced Developmental Programming of Hypertension in Adult Male Offspring.
Topics: Acetates; Animals; Blood Pressure; Dietary Supplements; Fatty Acids, Volatile; Female; Fructose; Gas | 2019 |
Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats.
Topics: Angiotensin II; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Anima | 2014 |
Investigations into biochemical changes of genetic hypertensive rats using 1H nuclear magnetic resonance-based metabonomics.
Topics: Animals; Citric Acid; Creatine; Creatinine; Dimethylamines; Disease Models, Animal; Hypertension; Ke | 2005 |
Pattern recognition analysis for classification of hypertensive model rats and diurnal variation using 1H-NMR spectroscopy of urine.
Topics: Animals; Circadian Rhythm; Citric Acid; Hypertension; Lactic Acid; Magnetic Resonance Spectroscopy; | 2005 |
1H NMR-based metabonomic analysis of urine from young spontaneously hypertensive rats.
Topics: Animals; Creatinine; Hippurates; Hypertension; Male; Methylamines; Nuclear Magnetic Resonance, Biomo | 2008 |