trimethyloxamine has been researched along with Heart Failure in 58 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Heart Failure: A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) and γ-butyrobetaine (GBB)-and heart failure with preserved ejection fraction (HFpEF) remains unclear." | 8.12 | Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events. ( Dong, E; Gao, J; Huang, M; Ji, L; Li, C; Wang, DW; Wang, Y; Wei, H; Wu, J; Zhang, Q; Zhao, C; Zhao, M; Zheng, L, 2022) |
| "Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)." | 8.02 | Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "Carnitine has been associated with cardiac energy metabolism and heart failure, but the association between its precursors-trimethyllysine (TML) and γ-butyrobetaine (GBB)-and heart failure with preserved ejection fraction (HFpEF) remains unclear." | 4.12 | Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events. ( Dong, E; Gao, J; Huang, M; Ji, L; Li, C; Wang, DW; Wang, Y; Wei, H; Wu, J; Zhang, Q; Zhao, C; Zhao, M; Zheng, L, 2022) |
| "Few studies have examined the associations of trimethylamine-N-oxide (TMAO) and its precursors (choline, betaine, dimethylglycine, and L-carnitine) with the risk of atrial fibrillation (AF) and heart failure (HF)." | 4.02 | Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study. ( Alonso-Gómez, A; Bulló, M; Clish, C; Corella, D; Estruch, R; Fiol, M; Fitó, M; Guasch-Ferré, M; Hernández-Alonso, P; Hu, FB; Li, J; Liang, L; Martínez-González, MA; Papandreou, C; Ros, E; Ruiz-Canela, M; Salas-Salvadó, J; Santos-Lozano, JM; Serra-Majem, L; Toledo, E, 2021) |
| "Trimethylamine N-oxide (TMAO), a gut-related metabolite, is associated with heart failure (HF) outcomes." | 4.02 | Association of gut-related metabolites with outcome in acute heart failure. ( Bernieh, D; Cassambai, S; Heaney, LM; Israr, MZ; Jones, DJL; Ng, LL; Salzano, A; Suzuki, T; Yazaki, Y, 2021) |
| "Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine." | 3.96 | Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020) |
| "To determine if differences exist in plasma concentrations of TMAO, choline, or l-carnitine among dogs with DMVD and congestive heart failure (CHF), dogs with asymptomatic DMVD, and healthy control dogs." | 3.91 | A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure. ( Freeman, LM; Karlin, ET; Rush, JE, 2019) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "This case-cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1." | 1.91 | Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. ( Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X, 2023) |
| "Patients with congestive heart failure (HF) develop intestinal wall edema due to venous congestion, which impairs absorption function and allows bacterial overgrowth." | 1.72 | Gut microbiome in heart failure and aortic stenosis. ( Dvorožňáková, M; Fülöp, P; Fülöpová, Z; Šoltys, K; Vachalcová, M; Valočik, G, 2022) |
| "Cardiac function, plasma TMAO level, cardiac hypertrophy and fibrosis, expression of inflammatory, electrophysiological studies and signaling pathway were analyzed at the sixth week after AB surgery." | 1.56 | 3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice. ( Fu, H; Huang, H; Jiang, X; Kong, B; Shuai, W; Wang, G, 2020) |
| "TMAO-treated rats with heart failure had lower blood pressure and urinated more than untreated rats with the condition." | 1.56 | TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats. ( Derzsi, L; Dobrowolski, L; Gawrys-Kopczynska, M; Holyst, R; Jaworska, K; Konop, M; Kraszewska, K; Maksymiuk, K; Mogilnicka, I; Pilz, M; Samborowska, E; Sozanski, K; Ufnal, M, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 19 (32.76) | 24.3611 |
| 2020's | 39 (67.24) | 2.80 |
| Authors | Studies |
|---|---|
| Lv, S | 1 |
| Wang, Y | 4 |
| Zhang, W | 1 |
| Shang, H | 2 |
| Bin-Jumah, MN | 1 |
| Gilani, SJ | 1 |
| Hosawi, S | 1 |
| Al-Abbasi, FA | 1 |
| Zeyadi, M | 1 |
| Imam, SS | 1 |
| Alshehri, S | 1 |
| Ghoneim, MM | 1 |
| Nadeem, MS | 1 |
| Kazmi, I | 1 |
| Chen, G | 1 |
| He, L | 1 |
| Dou, X | 1 |
| Liu, T | 1 |
| Konieczny, RA | 1 |
| Kuliczkowski, W | 2 |
| Salzano, A | 7 |
| Cassambai, S | 4 |
| Yazaki, Y | 7 |
| Israr, MZ | 6 |
| Bernieh, D | 4 |
| Wong, M | 2 |
| Suzuki, T | 9 |
| Gąsecka, A | 1 |
| Rzepa, Ł | 1 |
| Konwerski, M | 1 |
| Zawadzka, M | 1 |
| Wysocki, K | 1 |
| Budnik, M | 1 |
| Czub, P | 1 |
| Wilimski, R | 1 |
| Wondołkowski, M | 1 |
| Wilczyńska-Burlikowska, J | 1 |
| Scisło, P | 1 |
| Konop, M | 2 |
| Huczek, Z | 1 |
| Kochman, J | 1 |
| Kochanowski, J | 1 |
| Opolski, G | 1 |
| Filipiak, KJ | 1 |
| Ufnal, M | 3 |
| Kapłon-Cieślicka, A | 1 |
| Li, N | 1 |
| Zhou, J | 1 |
| Chen, R | 1 |
| Li, J | 3 |
| Zhao, X | 1 |
| Zhou, P | 1 |
| Liu, C | 1 |
| Song, L | 1 |
| Liao, Z | 1 |
| Wang, X | 2 |
| Yan, S | 1 |
| Zhao, H | 1 |
| Yan, H | 1 |
| Anderson, KM | 1 |
| Ferranti, EP | 1 |
| Alagha, EC | 1 |
| Mykityshyn, E | 1 |
| French, CE | 1 |
| Reilly, CM | 1 |
| Qiu, WD | 1 |
| Xiao, XJ | 1 |
| Xia, S | 1 |
| Gao, ZP | 1 |
| Li, LW | 1 |
| Konieczny, R | 1 |
| Żurawska-Płaksej, E | 1 |
| Kaaz, K | 1 |
| Czapor-Irzabek, H | 1 |
| Bombała, W | 1 |
| Mysiak, A | 1 |
| Yoshida, Y | 2 |
| Shimizu, I | 1 |
| Shimada, A | 1 |
| Nakahara, K | 1 |
| Yanagisawa, S | 1 |
| Kubo, M | 1 |
| Fukuda, S | 1 |
| Ishii, C | 1 |
| Yamamoto, H | 1 |
| Ishikawa, T | 1 |
| Kano, K | 1 |
| Aoki, J | 1 |
| Katsuumi, G | 1 |
| Suda, M | 1 |
| Ozaki, K | 1 |
| Okuda, S | 1 |
| Ohta, S | 1 |
| Okamoto, S | 1 |
| Minokoshi, Y | 1 |
| Oda, K | 1 |
| Sasaoka, T | 1 |
| Abe, M | 1 |
| Sakimura, K | 1 |
| Kubota, Y | 1 |
| Yoshimura, N | 1 |
| Kajimura, S | 1 |
| Zuriaga, M | 1 |
| Walsh, K | 1 |
| Soga, T | 1 |
| Minamino, T | 1 |
| Wei, H | 2 |
| Zhao, M | 2 |
| Wu, J | 1 |
| Li, C | 2 |
| Huang, M | 2 |
| Gao, J | 2 |
| Zhang, Q | 2 |
| Ji, L | 2 |
| Zhao, C | 2 |
| Dong, E | 2 |
| Zheng, L | 2 |
| Wang, DW | 2 |
| Fülöp, P | 1 |
| Dvorožňáková, M | 1 |
| Vachalcová, M | 1 |
| Fülöpová, Z | 1 |
| Šoltys, K | 1 |
| Valočik, G | 1 |
| Crisci, G | 1 |
| Cittadini, A | 1 |
| Bossone, E | 1 |
| Weng, JQ | 1 |
| Li, JB | 1 |
| Yuan, MF | 1 |
| Yao, TT | 1 |
| Zhang, JF | 1 |
| Zeng, YY | 1 |
| Zhao, J | 1 |
| Li, Y | 1 |
| Xu, K | 1 |
| Shen, XX | 1 |
| Gui, XY | 2 |
| Rabkin, SW | 2 |
| Schrauben, SJ | 1 |
| Sapa, H | 1 |
| Xie, D | 1 |
| Zhang, X | 2 |
| Anderson, AH | 1 |
| Shlipak, MG | 1 |
| Hsu, CY | 1 |
| Shafi, T | 1 |
| Mehta, R | 1 |
| Bhat, Z | 1 |
| Brown, J | 1 |
| Charleston, J | 1 |
| Chen, J | 1 |
| He, J | 1 |
| Ix, JH | 1 |
| Rao, P | 1 |
| Townsend, R | 1 |
| Kimmel, PL | 1 |
| Vasan, RS | 1 |
| Feldman, HI | 1 |
| Seegmiller, JC | 1 |
| Brunengraber, H | 1 |
| Hostetter, TH | 1 |
| Schelling, JR | 1 |
| Cui, H | 1 |
| Han, S | 1 |
| Dai, Y | 1 |
| Xie, W | 1 |
| Zheng, R | 1 |
| Sun, Y | 2 |
| Xia, X | 1 |
| Deng, X | 1 |
| Cao, Y | 1 |
| Zhang, M | 1 |
| Belli, M | 1 |
| Barone, L | 1 |
| Longo, S | 1 |
| Prandi, FR | 1 |
| Lecis, D | 1 |
| Mollace, R | 1 |
| Margonato, D | 1 |
| Muscoli, S | 1 |
| Sergi, D | 1 |
| Federici, M | 1 |
| Barillà, F | 1 |
| Heaney, LM | 3 |
| Kanagala, P | 1 |
| Singh, A | 1 |
| Arnold, JR | 1 |
| Gulsin, GS | 1 |
| Squire, IB | 1 |
| McCann, GP | 1 |
| Ng, LL | 6 |
| Formiga, F | 1 |
| Ferreira Teles, CI | 1 |
| Chivite, D | 1 |
| Kuehn, BM | 1 |
| Zhou, X | 3 |
| Jin, M | 2 |
| Liu, L | 1 |
| Yu, Z | 1 |
| Lu, X | 1 |
| Zhang, H | 1 |
| Wang, G | 1 |
| Kong, B | 1 |
| Shuai, W | 1 |
| Fu, H | 1 |
| Jiang, X | 1 |
| Huang, H | 1 |
| Jin, B | 1 |
| Ji, F | 1 |
| Zuo, A | 1 |
| Liu, H | 1 |
| Qi, L | 1 |
| He, Y | 1 |
| Wang, Q | 1 |
| Zhao, P | 1 |
| Organ, CL | 2 |
| Li, Z | 1 |
| Sharp, TE | 1 |
| Polhemus, DJ | 2 |
| Gupta, N | 1 |
| Goodchild, TT | 1 |
| Tang, WHW | 1 |
| Hazen, SL | 3 |
| Lefer, DJ | 2 |
| Gawrys-Kopczynska, M | 1 |
| Maksymiuk, K | 1 |
| Kraszewska, K | 2 |
| Derzsi, L | 1 |
| Sozanski, K | 1 |
| Holyst, R | 1 |
| Pilz, M | 1 |
| Samborowska, E | 2 |
| Dobrowolski, L | 1 |
| Jaworska, K | 2 |
| Mogilnicka, I | 2 |
| Aizawa, K | 1 |
| Negishi, K | 1 |
| Saitoh, Y | 1 |
| Kimura, N | 1 |
| Kono, K | 1 |
| Heaney, L | 1 |
| Lai, F | 1 |
| Imai, Y | 1 |
| Kario, K | 1 |
| Nagai, R | 1 |
| Zhang, Y | 1 |
| Ke, B | 1 |
| Du, J | 1 |
| Drapala, A | 1 |
| Szudzik, M | 1 |
| Chabowski, D | 1 |
| Dong, Z | 2 |
| Liang, Z | 1 |
| Liu, W | 1 |
| Zhao, L | 1 |
| Wang, S | 1 |
| Hai, X | 2 |
| Yu, K | 1 |
| Li, W | 1 |
| Huang, A | 1 |
| Zhu, H | 1 |
| Liu, X | 1 |
| Huang, X | 1 |
| Huang, Y | 2 |
| Cai, X | 1 |
| Lu, J | 1 |
| Atherton, JJ | 1 |
| Punyadeera, C | 1 |
| Zheng, S | 1 |
| Shen, Z | 1 |
| Luo, Y | 1 |
| Papandreou, C | 1 |
| Bulló, M | 1 |
| Hernández-Alonso, P | 1 |
| Ruiz-Canela, M | 1 |
| Guasch-Ferré, M | 1 |
| Toledo, E | 1 |
| Clish, C | 1 |
| Corella, D | 1 |
| Estruch, R | 1 |
| Ros, E | 1 |
| Fitó, M | 1 |
| Alonso-Gómez, A | 1 |
| Fiol, M | 1 |
| Santos-Lozano, JM | 1 |
| Serra-Majem, L | 1 |
| Liang, L | 1 |
| Martínez-González, MA | 1 |
| Hu, FB | 1 |
| Salas-Salvadó, J | 1 |
| Jones, DJL | 2 |
| Mollar, A | 1 |
| Marrachelli, VG | 1 |
| Núñez, E | 1 |
| Monleon, D | 1 |
| Bodí, V | 1 |
| Sanchis, J | 1 |
| Navarro, D | 1 |
| Núñez, J | 1 |
| Kinugasa, Y | 1 |
| Nakamura, K | 1 |
| Kamitani, H | 1 |
| Hirai, M | 1 |
| Yanagihara, K | 1 |
| Kato, M | 1 |
| Yamamoto, K | 1 |
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| Bohn, B | 1 |
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| Mondellini, GM | 1 |
| Braghieri, L | 1 |
| Pinsino, A | 1 |
| Onat, D | 1 |
| Cagliostro, B | 1 |
| Kim, A | 1 |
| Takeda, K | 1 |
| Naka, Y | 1 |
| Farr, M | 1 |
| Sayer, GT | 1 |
| Uriel, N | 1 |
| Nandakumar, R | 1 |
| Mohan, S | 1 |
| Colombo, PC | 1 |
| Demmer, RT | 1 |
| Yu, T | 1 |
| Shen, X | 1 |
| Ni, L | 1 |
| Wang, Z | 3 |
| Subramaniam, S | 1 |
| Fletcher, C | 1 |
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| Cleland, JG | 2 |
| Dickstein, K | 1 |
| Filippatos, G | 1 |
| Hillege, HL | 1 |
| Lang, CC | 2 |
| Ponikowski, P | 1 |
| Samani, NJ | 2 |
| van Veldhuisen, DJ | 1 |
| Zannad, F | 1 |
| Zwinderman, AH | 1 |
| Metra, M | 2 |
| Karlin, ET | 1 |
| Rush, JE | 1 |
| Freeman, LM | 1 |
| Chioncel, O | 1 |
| Ambrosy, AP | 1 |
| Polsinelli, VB | 1 |
| Marteau, L | 1 |
| Shah, SJ | 1 |
| Qian, Z | 1 |
| Yin, J | 1 |
| Xu, W | 1 |
| Li, X | 1 |
| Wang, J | 1 |
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| Ueland, T | 1 |
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| Gregersen, I | 1 |
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| Aakhus, S | 1 |
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| Halvorsen, B | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Association Analysis of Cardiovascular and Nervous System Diseases and Intestinal Microbiome Based on Multi-omics Big Data and Related Applications[NCT06099496] | 490 participants (Anticipated) | Observational [Patient Registry] | 2023-04-01 | Recruiting | |||
| GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167] | Phase 2 | 150 participants (Anticipated) | Interventional | 2016-03-11 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 reviews available for trimethyloxamine and Heart Failure
| Article | Year |
|---|---|
Trimethylamine oxide: a potential target for heart failure therapy.
Topics: Cardiotonic Agents; Carnitine; Choline; Diuretics; Gastrointestinal Microbiome; Heart Failure; Human | 2022 |
Pathobiological Relationship of Excessive Dietary Intake of Choline/L-Carnitine: A TMAO Precursor-Associated Aggravation in Heart Failure in Sarcopenic Patients.
Topics: Biodiversity; Biomarkers; Carnitine; Choline; Dietary Supplements; Disease Susceptibility; Dysbiosis | 2021 |
Association of Trimethylamine-N-Oxide Levels with Risk of Cardiovascular Disease and Mortality among Elderly Subjects: A Systematic Review and Meta-Analysis.
Topics: Aged; Biomarkers; Cardiovascular Diseases; Heart Failure; Humans; Methylamines; Oxides; Prospective | 2022 |
Trimethylamine N-oxide in cardiovascular disease.
Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines | 2022 |
The Gut Axis Involvement in Heart Failure: Focus on Trimethylamine N-oxide.
Topics: Choline; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines | 2022 |
The heart and gut relationship: a systematic review of the evaluation of the microbiome and trimethylamine-N-oxide (TMAO) in heart failure.
Topics: Heart Failure; Humans; Methylamines; Microbiota; Oxides; RNA, Ribosomal, 16S | 2022 |
C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.
Topics: Biomarkers; C-Reactive Protein; Heart Failure; Humans; Interleukin-6; Natriuretic Peptide, Brain; Ni | 2023 |
C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.
Topics: Biomarkers; C-Reactive Protein; Heart Failure; Humans; Interleukin-6; Natriuretic Peptide, Brain; Ni | 2023 |
C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.
Topics: Biomarkers; C-Reactive Protein; Heart Failure; Humans; Interleukin-6; Natriuretic Peptide, Brain; Ni | 2023 |
C-Reactive Protein, Interleukin-6, Trimethylamine-N-Oxide, Syndecan-1, Nitric Oxide, and Tumor Necrosis Factor Receptor-1 in Heart Failure with Preserved Versus Reduced Ejection Fraction: a Meta-Analysis.
Topics: Biomarkers; C-Reactive Protein; Heart Failure; Humans; Interleukin-6; Natriuretic Peptide, Brain; Ni | 2023 |
Gut microbiota and integrative traditional Chinese and western medicine in prevention and treatment of heart failure.
Topics: Drugs, Chinese Herbal; Gastrointestinal Microbiome; Heart Failure; Humans; Medicine, Chinese Traditi | 2023 |
Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines | 2023 |
Impact of intestinal microbiota in patients with heart failure: A systematic review.
Topics: Biomarkers; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines; Prognosis | 2019 |
The Gut Axis Involvement in Heart Failure: Focus on Trimethylamine N-oxide.
Topics: Biomarkers; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines; Prognosis; Stroke Volu | 2020 |
TMAO: how gut microbiota contributes to heart failure.
Topics: Gastrointestinal Microbiome; Heart Failure; Humans; Intestinal Mucosa; Methylamines | 2021 |
Gut microbiota-derived trimethylamine N-oxide is associated with poor prognosis in patients with heart failure.
Topics: Cause of Death; Gastrointestinal Microbiome; Heart Failure; Heart Transplantation; Hospitalization; | 2020 |
Trimethylamine N-oxide: breathe new life.
Topics: Animals; Brain Diseases; Heart Failure; Humans; Methylamines; Neoplasms; Obesity; Thrombosis | 2018 |
The role of splanchnic congestion and the intestinal microenvironment in the pathogenesis of advanced heart failure.
Topics: Disease Progression; Enterocytes; Fatty Acids, Volatile; Gastrointestinal Microbiome; Heart Failure; | 2019 |
The role of intestinal microbiota in cardiovascular disease.
Topics: Bile Acids and Salts; Cardiovascular Diseases; Dysbiosis; Fatty Acids; Gastrointestinal Microbiome; | 2019 |
Intersections Between Microbiome and Heart Failure: Revisiting the Gut Hypothesis.
Topics: Female; Gastrointestinal Microbiome; Heart Failure; Homeostasis; Humans; Male; Methylamines; Microbi | 2015 |
Exploring the Microbiome in Heart Failure.
Topics: Cardio-Renal Syndrome; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines; Microbiota | 2016 |
1 trial available for trimethyloxamine and Heart Failure
| Article | Year |
|---|---|
Bacterial metabolites trimethylamine N-oxide and butyrate as surrogates of small intestinal bacterial overgrowth in patients with a recent decompensated heart failure.
Topics: Aged; Bacteria; Biomarkers; Blind Loop Syndrome; Breath Tests; Butyrates; Female; Heart Failure; Hum | 2021 |
39 other studies available for trimethyloxamine and Heart Failure
| Article | Year |
|---|---|
Trimethylamine-N-oxide (TMAO) versus echocardiographic, biochemical and histopathological indices of heart failure in patients with severe aortic stenosis: Rationale and design of the prospective, observational TASTE study.
Topics: Aortic Valve Stenosis; Echocardiography; Heart Failure; Humans; Methylamines; Oxides; Prospective St | 2022 |
Association between trimethylamine N-oxide and prognosis of patients with acute myocardial infarction and heart failure.
Topics: C-Reactive Protein; Heart Failure; Humans; Myocardial Infarction; Prognosis | 2022 |
[Predictive value of plasma TMAO combined with NT-proBNP on the prognosis and length of hospitalization of patients with ischemic heart failure].
Topics: Aged; Biomarkers; Female; Heart Failure; Hospitalization; Humans; Male; Methylamines; Middle Aged; N | 2022 |
All-Cause Mortality and Trimethylamine N-Oxide Levels in Patients with Cardiovascular Disease.
Topics: Atrial Fibrillation; Biomarkers; Cardiovascular Diseases; Female; Heart Failure; Humans; Male; Methy | 2022 |
Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism.
Topics: Adipocytes, Brown; Adipose Tissue, Brown; Animals; Choline; Heart Failure; Methylamines; Mice; Myoca | 2022 |
Association of Systemic Trimethyllysine With Heart Failure With Preserved Ejection Fraction and Cardiovascular Events.
Topics: Carnitine; Cross-Sectional Studies; Heart Failure; Humans; Prospective Studies; Stroke Volume | 2022 |
Gut microbiome in heart failure and aortic stenosis.
Topics: Aortic Valve Stenosis; Gastrointestinal Microbiome; Heart Failure; Humans; Lipopolysaccharides; Meth | 2022 |
Heart failure and trimethylamine N-oxide: time to transform a 'gut feeling' in a fact?
Topics: Heart Failure; Humans; Methylamines | 2023 |
Effects of Buyang Huanwu Decoction on Intestinal Barrier, Intestinal Flora, and Trimethylamine Oxide in Rats with Heart Failure.
Topics: Animals; Chromatography, Liquid; Claudin-1; Drugs, Chinese Herbal; Gastrointestinal Microbiome; Hear | 2023 |
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; D | 2023 |
Combined use of trimethylamine N-oxide with BNP for risk stratification in heart failure with preserved ejection fraction: findings from the DIAMONDHFpEF study.
Topics: Aged; Biomarkers; Case-Control Studies; Female; Heart Failure; Humans; Male; Methylamines; Middle Ag | 2020 |
Gut Microbes Role in Heart Failure Explored.
Topics: Atherosclerosis; Bacteria; Butyrates; Diet; Dietary Fiber; Gastrointestinal Microbiome; Heart Failur | 2019 |
Trimethylamine N-oxide and cardiovascular outcomes in patients with chronic heart failure after myocardial infarction.
Topics: Aged; Aged, 80 and over; Biomarkers; Female; Follow-Up Studies; Heart Failure; Humans; Male; Methyla | 2020 |
3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Echocardiography; Electrocardiography; Fibroblasts; H | 2020 |
Destructive Role of TMAO in T-Tubule and Excitation-Contraction Coupling in the Adult Cardiomyocytes.
Topics: Animals; Calcium; Cells, Cultured; Excitation Contraction Coupling; Heart Failure; Male; Membrane Pr | 2020 |
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi | 2020 |
TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats.
Topics: Angiotensins; Animals; Diuresis; Gene Expression Regulation; Heart Failure; Kidney; Male; Methylamin | 2020 |
Ethnic differences in association of outcomes with trimethylamine N-oxide in acute heart failure patients.
Topics: Cohort Studies; Heart Failure; Humans; Methylamines | 2020 |
Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite.
Topics: Animals; Bacteria; Chromatography, High Pressure Liquid; Feces; Gastrointestinal Microbiome; Heart F | 2020 |
The correlation between plasma trimethylamine N-oxide level and heart failure classification in northern Chinese patients.
Topics: Biomarkers; China; Heart Failure; Humans; Methylamines; Predictive Value of Tests; Prognosis | 2020 |
Should patients with heart failure listen to their gut?
Topics: Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines; Prognosis | 2020 |
Trimethylamine N-Oxide is Associated with Heart Failure Risk in Patients with Preserved Ejection Fraction.
Topics: Biomarkers; Heart Failure; Humans; Methylamines; Natriuretic Peptide, Brain; Peptide Fragments; Prog | 2021 |
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study.
Topics: Aged; Atrial Fibrillation; Betaine; Carnitine; Case-Control Studies; Choline; Female; Heart Failure; | 2021 |
Association of gut-related metabolites with outcome in acute heart failure.
Topics: Acetylcarnitine; Acute Disease; Aged; Aged, 80 and over; Betaine; Carnitine; Choline; Female; Gastro | 2021 |
Trimethylamine N-oxide and outcomes in patients hospitalized with acute heart failure and preserved ejection fraction.
Topics: Aftercare; Heart Failure; Humans; Methylamines; Patient Discharge; Risk Factors; Stroke Volume | 2021 |
Levels of Trimethylamine N-Oxide Remain Elevated Long Term After Left Ventricular Assist Device and Heart Transplantation and Are Independent From Measures of Inflammation and Gut Dysbiosis.
Topics: Aged; Aged, 80 and over; Dysbiosis; Female; Gastrointestinal Microbiome; Heart Failure; Heart Transp | 2021 |
FMO3-TMAO axis modulates the clinical outcome in chronic heart-failure patients with reduced ejection fraction: evidence from an Asian population.
Topics: Carnitine; Choline; Chronic Disease; Heart Failure; Humans; Methylamines; Oxygenases; Prospective St | 2022 |
Metagenomic and metabolomic analyses unveil dysbiosis of gut microbiota in chronic heart failure patients.
Topics: Adult; Aged; Bacteria; Butyrates; Dysbiosis; Female; Gastrointestinal Microbiome; Heart Failure; Hum | 2018 |
Association with outcomes and response to treatment of trimethylamine N-oxide in heart failure: results from BIOSTAT-CHF.
Topics: Biomarkers, Pharmacological; Disease Progression; Europe; Female; Heart Failure; Hospitalization; Hu | 2019 |
A pilot study investigating circulating trimethylamine N-oxide and its precursors in dogs with degenerative mitral valve disease with or without congestive heart failure.
Topics: Animals; Carnitine; Case-Control Studies; Choline; Cross-Sectional Studies; Dog Diseases; Dogs; Echo | 2019 |
Trimethylamine N-oxide and risk of heart failure progression: marker or mediator of disease.
Topics: Biomarkers; Disease Progression; Heart Failure; Humans; Methylamines | 2019 |
Reductions in gut microbiota‑derived metabolite trimethylamine N‑oxide in the circulation may ameliorate myocardial infarction‑induced heart failure in rats, possibly by inhibiting interleukin‑8 secretion.
Topics: Animals; Gastrointestinal Microbiome; Heart Failure; Hexanols; Interleukin-8; Male; Methylamines; My | 2019 |
Geographical location affects the levels and association of trimethylamine N-oxide with heart failure mortality in BIOSTAT-CHF: a post-hoc analysis.
Topics: Aged; Aged, 80 and over; Female; Heart Failure; Humans; Internationality; Male; Methylamines; Middle | 2019 |
Microbiota-dependent metabolite trimethylamine-N-oxide is associated with disease severity and survival of patients with chronic heart failure.
Topics: Aged; Betaine; Biomarkers; Choline; Chronic Disease; Female; Heart Failure; Humans; Intestinal Mucos | 2015 |
Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis.
Topics: Aged; Biomarkers; Female; Follow-Up Studies; Heart Failure; Humans; Intestinal Mucosa; Intestines; K | 2014 |
Gut feelings about heart failure.
Topics: Female; Heart Failure; Humans; Intestinal Mucosa; Male; Methylamines; Microbiota; Risk Assessment | 2014 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |
Trimethylamine N-oxide and prognosis in acute heart failure.
Topics: Acute Disease; Aged; Aged, 80 and over; Biomarkers; Chi-Square Distribution; Chromatography, Liquid; | 2016 |
Trimethylamine-N-oxide (TMAO) predicts fatal outcomes in community-acquired pneumonia patients without evident coronary artery disease.
Topics: Age Factors; Aged; Aged, 80 and over; Anti-Bacterial Agents; Cause of Death; Cerebrovascular Disorde | 2016 |