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trimethyloxamine and Fatty Liver, Nonalcoholic

trimethyloxamine has been researched along with Fatty Liver, Nonalcoholic in 10 studies

trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.

Research Excerpts

ExcerptRelevanceReference
"Evidence shows that trimethylamine (TMA)/trimethylamine-N-oxide (TMAO) is closely related to non-alcoholic fatty liver disease (NAFLD)."8.12Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine. ( Cao, P; Chen, Q; Deng, W; Gong, Z; Guo, J; Li, X; Pei, M; Shi, C; Wang, L; Wang, Y; Zhang, L, 2022)
"Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk of cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD)."7.83Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. ( Chen, XL; Chen, YM; Ling, WH; Liu, Y; Tan, XY; Wang, C; Wang, LJ; Zhang, HW; Zheng, RD; Zhou, RF; Zhu, HL, 2016)
"Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder with complicated pathophysiology."5.72Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. ( Abdi, M; Ghaderi, D; Moloudi, MR; Moradzad, M; Rahmani, K; Sheikh Esmaeili, F; Vahabzadeh, Z, 2022)
"Evidence shows that trimethylamine (TMA)/trimethylamine-N-oxide (TMAO) is closely related to non-alcoholic fatty liver disease (NAFLD)."4.12Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine. ( Cao, P; Chen, Q; Deng, W; Gong, Z; Guo, J; Li, X; Pei, M; Shi, C; Wang, L; Wang, Y; Zhang, L, 2022)
"Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)."4.02Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021)
"Many studies suggest that trimethylamine-N-oxide (TMAO), a gut-flora-dependent metabolite of choline, contributes to the risk of cardiovascular diseases, but little is known for non-alcoholic fatty liver disease (NAFLD)."3.83Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults. ( Chen, XL; Chen, YM; Ling, WH; Liu, Y; Tan, XY; Wang, C; Wang, LJ; Zhang, HW; Zheng, RD; Zhou, RF; Zhu, HL, 2016)
"Choline is a water-soluble nutrient essential for human life."2.66The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. ( Allison, J; Arboleya, S; Arias, JL; Arias, N; Gueimonde, M; Higarza, SG; Kaliszewska, A, 2020)
"Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disease worldwide but still lacks specific treatment modalities."1.91Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro. ( Jin, N; Lu, X; Nian, F; Wu, L; Xia, Q; Zhu, C, 2023)
"Non-alcoholic fatty liver disease (NAFLD) is a multifactorial disorder with complicated pathophysiology."1.72Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease. ( Abdi, M; Ghaderi, D; Moloudi, MR; Moradzad, M; Rahmani, K; Sheikh Esmaeili, F; Vahabzadeh, Z, 2022)
"Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes with no approved therapies."1.72Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis. ( Ding, BS; Mo, C; Xiao, C; Zhang, J; Zhou, D, 2022)
"However, its role in nonalcoholic steatohepatitis (NASH) is unknown."1.51Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats. ( Fan, JG; Liu, XL; Pan, Q; Xin, FZ; Xue, YQ; Yang, RX; Zhao, ZH; Zhou, D, 2019)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (30.00)24.3611
2020's7 (70.00)2.80

Authors

AuthorsStudies
Shi, C1
Pei, M1
Wang, Y1
Chen, Q1
Cao, P1
Zhang, L1
Guo, J1
Deng, W1
Wang, L2
Li, X1
Gong, Z1
Moradzad, M1
Abdi, M1
Sheikh Esmaeili, F1
Ghaderi, D1
Rahmani, K1
Moloudi, MR1
Vahabzadeh, Z1
Zhou, D2
Zhang, J1
Xiao, C1
Mo, C1
Ding, BS1
Nian, F1
Zhu, C1
Jin, N1
Xia, Q1
Wu, L1
Lu, X1
Arias, N1
Arboleya, S1
Allison, J1
Kaliszewska, A1
Higarza, SG1
Gueimonde, M1
Arias, JL1
León-Mimila, P1
Villamil-Ramírez, H1
Li, XS1
Shih, DM1
Hui, ST1
Ocampo-Medina, E1
López-Contreras, B1
Morán-Ramos, S1
Olivares-Arevalo, M1
Grandini-Rosales, P1
Macías-Kauffer, L1
González-González, I1
Hernández-Pando, R1
Gómez-Pérez, F1
Campos-Pérez, F1
Aguilar-Salinas, C1
Larrieta-Carrasco, E1
Villarreal-Molina, T1
Wang, Z1
Lusis, AJ1
Hazen, SL1
Huertas-Vazquez, A1
Canizales-Quinteros, S1
Flores-Guerrero, JL1
Post, A1
van Dijk, PR1
Connelly, MA1
Garcia, E1
Navis, G1
Bakker, SJL1
Dullaart, RPF1
Tan, X1
Liu, Y2
Long, J1
Chen, S1
Liao, G1
Wu, S1
Li, C1
Ling, W1
Zhu, H1
Zhao, ZH1
Xin, FZ1
Xue, YQ1
Liu, XL1
Yang, RX1
Pan, Q1
Fan, JG1
Chen, YM1
Zhou, RF1
Chen, XL1
Wang, C1
Tan, XY1
Wang, LJ1
Zheng, RD1
Zhang, HW1
Ling, WH1
Zhu, HL1

Reviews

1 review available for trimethyloxamine and Fatty Liver, Nonalcoholic

ArticleYear
The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases.
    Nutrients, 2020, Aug-05, Volume: 12, Issue:8

    Topics: Animals; Biological Availability; Cardiovascular Diseases; Choline; Diet; Dysbiosis; Gastrointestina

2020

Other Studies

9 other studies available for trimethyloxamine and Fatty Liver, Nonalcoholic

ArticleYear
Changes of flavin-containing monooxygenases and trimethylamine-N-oxide may be involved in the promotion of non-alcoholic fatty liver disease by intestinal microbiota metabolite trimethylamine.
    Biochemical and biophysical research communications, 2022, 02-26, Volume: 594

    Topics: Animals; Cell Line; Endoplasmic Reticulum Chaperone BiP; Gastrointestinal Microbiome; Gene Silencing

2022
Possible correlation between high circulatory levels of trimethylamine-N-oxide and 2177G>C polymorphisms of hepatic flavin containing monooxygenase 3 in Kurdish Population with non-alcoholic fatty liver disease.
    Molecular biology reports, 2022, Volume: 49, Issue:7

    Topics: Case-Control Studies; Chromatography, Liquid; Flavins; Humans; Methylamines; Mixed Function Oxygenas

2022
Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis.
    Frontiers in immunology, 2022, Volume: 13

    Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Liver Cirrhosis; Methylamines; Mice; N

2022
Gut microbiota metabolite TMAO promoted lipid deposition and fibrosis process via KRT17 in fatty liver cells in vitro.
    Biochemical and biophysical research communications, 2023, 08-20, Volume: 669

    Topics: Fibrosis; Gastrointestinal Microbiome; Humans; Lipids; Liver Cirrhosis; Methylamines; Non-alcoholic

2023
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
    Diabetes & metabolism, 2021, Volume: 47, Issue:2

    Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female

2021
Circulating trimethylamine-N-oxide is associated with all-cause mortality in subjects with nonalcoholic fatty liver disease.
    Liver international : official journal of the International Association for the Study of the Liver, 2021, Volume: 41, Issue:10

    Topics: Biomarkers; Cohort Studies; Humans; Methylamines; Non-alcoholic Fatty Liver Disease; Oxides; Prospec

2021
Trimethylamine N-Oxide Aggravates Liver Steatosis through Modulation of Bile Acid Metabolism and Inhibition of Farnesoid X Receptor Signaling in Nonalcoholic Fatty Liver Disease.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:17

    Topics: Adult; Animals; Bile Acids and Salts; Case-Control Studies; Cholesterol 7-alpha-Hydroxylase; Diet, H

2019
Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats.
    World journal of gastroenterology, 2019, May-28, Volume: 25, Issue:20

    Topics: Administration, Oral; Animals; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Disease

2019
Associations of gut-flora-dependent metabolite trimethylamine-N-oxide, betaine and choline with non-alcoholic fatty liver disease in adults.
    Scientific reports, 2016, Jan-08, Volume: 6

    Topics: Adolescent; Adult; Aged; Betaine; Biomarkers; Case-Control Studies; Choline; Chromatography, High Pr

2016