trimethyloxamine has been researched along with Disease Models, Animal in 62 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Disease Models, Animal: Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 8.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 7.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "2% adenine diet for 14 weeks developed CKD with elevated plasma levels of TMAO, provision of a non-lethal inhibitor of gut microbial trimethylamine (TMA) production, iodomethylcholine (IMC), significantly reduced multiple markers of renal injury (plasma creatinine, cystatin C, FGF23, and TMAO), reduced histopathologic evidence of fibrosis, and markedly attenuated development of microalbuminuria." | 4.02 | Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice. ( Charugundla, S; Guo, F; Hazen, SL; Jia, X; Kaczor-Urbanowicz, KE; Lusis, AJ; Magyar, C; Miikeda, A; Nicholas, SB; Pellegrini, M; Shih, DM; Wang, Z; Zhang, W; Zhou, Z; Zuckerman, J, 2021) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 4.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Gut microbial metabolism of dietary choline, a nutrient abundant in a Western diet, produces trimethylamine (TMA) and the atherothrombosis- and fibrosis-promoting metabolite TMA-N-oxide (TMAO)." | 3.96 | Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease. ( Buffa, JA; DiDonato, JA; Gupta, N; Hazen, SL; Ho, KJ; Li, L; Roberts, AB; Sangwan, N; Skye, SM; Tang, WHW; Varga, J, 2020) |
| "Background Patients at increased risk for coronary artery disease and adverse prognosis during heart failure exhibit increased levels of circulating trimethylamine N-oxide (TMAO), a metabolite formed in the metabolism of dietary phosphatidylcholine." | 3.96 | Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure. ( Goodchild, TT; Gupta, N; Hazen, SL; Lefer, DJ; Li, Z; Organ, CL; Polhemus, DJ; Sharp, TE; Tang, WHW, 2020) |
| " Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo." | 3.88 | Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018) |
| "Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite of dietary choline and other trimethylamine-containing nutrients, is both elevated in the circulation of patients having heart failure and heralds worse overall prognosis." | 3.83 | Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure. ( Bhushan, S; Bradley, J; Hazen, SL; Lefer, DJ; Organ, CL; Otsuka, H; Polhemus, DJ; Tang, WH; Trivedi, R; Wang, Z; Wu, Y, 2016) |
| "The choline-derived metabolite trimethylamine N-oxide (TMAO) has been demonstrated to contribute to atherosclerosis and is associated with coronary artery disease risk." | 3.83 | Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB. ( Hazen, SL; Lusis, AJ; Meng, Y; Qi, H; Seldin, MM; Shih, DM; Wang, Z; Zhu, W, 2016) |
| "Phenylacetylglutamine, for example, was recently shown to promote adverse cardiovascular phenotypes in the host via interaction with multiple ARs (adrenergic receptors)-a class of key receptors that regulate cardiovascular homeostasis." | 2.66 | Gut Microbiota and Cardiovascular Disease. ( Hazen, SL; Weeks, TL; Witkowski, M, 2020) |
| "Liver fibrosis is one main histological characteristic of nonalcoholic steatohepatitis (NASH), a disease paralleling a worldwide surge in metabolic syndromes with no approved therapies." | 1.72 | Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis. ( Ding, BS; Mo, C; Xiao, C; Zhang, J; Zhou, D, 2022) |
| "Vascular calcification is highly prevalent in patients with chronic kidney disease." | 1.56 | Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals. ( Chen, M; Chen, Y; Li, Y; Li, Z; Liu, H; Liu, X; Lu, L; Ou, C; Yan, J; Yang, P; Zhang, X; Zhong, X, 2020) |
| "Cardiac function, plasma TMAO level, cardiac hypertrophy and fibrosis, expression of inflammatory, electrophysiological studies and signaling pathway were analyzed at the sixth week after AB surgery." | 1.56 | 3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice. ( Fu, H; Huang, H; Jiang, X; Kong, B; Shuai, W; Wang, G, 2020) |
| "Trimethylamine was used as a probe substrate to assess FMO activity." | 1.51 | Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease. ( Leblond, FA; Nolin, TD; Pichette, V; Prokopienko, AJ; Schrum, DP; Stubbs, JR; West, RE, 2019) |
| "Additionally, TMAO treatment induced cardiac hypertrophy and cardiac fibrosis in SD rats." | 1.51 | Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis. ( Chen, M; Deng, Y; Li, Z; Liu, H; Liu, Q; Ou, C; Wu, Z; Yan, J, 2019) |
| "However, its role in nonalcoholic steatohepatitis (NASH) is unknown." | 1.51 | Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats. ( Fan, JG; Liu, XL; Pan, Q; Xin, FZ; Xue, YQ; Yang, RX; Zhao, ZH; Zhou, D, 2019) |
| "Atherosclerosis is a multifactorial and progressive disease commonly correlated with a high fat diet." | 1.40 | Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy. ( Guo, J; Li, J; Li, X; Liu, Y; Wang, L; Wu, T; Yang, Y; Yuan, F; Zhang, Q; Zheng, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (4.84) | 29.6817 |
| 2010's | 29 (46.77) | 24.3611 |
| 2020's | 30 (48.39) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, X | 7 |
| Shi, L | 1 |
| Chen, R | 1 |
| Zhao, Y | 1 |
| Ren, D | 1 |
| Yang, X | 1 |
| Coué, M | 1 |
| Croyal, M | 1 |
| Habib, M | 1 |
| Castellano, B | 1 |
| Aguesse, A | 2 |
| Grit, I | 1 |
| Gourdel, M | 1 |
| Billard, H | 1 |
| Lépine, O | 1 |
| Michel, C | 1 |
| Ouguerram, K | 2 |
| Yang, G | 1 |
| Liu, A | 1 |
| Zhang, Y | 3 |
| Xun, S | 1 |
| Sun, M | 1 |
| Hu, J | 1 |
| Xu, J | 1 |
| Shen, S | 1 |
| Zhang, W | 2 |
| Chen, H | 2 |
| Sun, X | 1 |
| Qi, Y | 1 |
| Zhang, Q | 2 |
| Guo, M | 1 |
| Peng, N | 1 |
| Xu, B | 1 |
| Li, C | 1 |
| Zhu, L | 2 |
| Dai, Y | 1 |
| Zhang, Z | 1 |
| Huang, L | 1 |
| Wang, TJ | 1 |
| Fu, P | 1 |
| Li, Y | 2 |
| Wang, J | 3 |
| Jiang, C | 1 |
| Lanz, M | 1 |
| Janeiro, MH | 1 |
| Milagro, FI | 1 |
| Puerta, E | 1 |
| Ludwig, IA | 1 |
| Pineda-Lucena, A | 1 |
| Ramírez, MJ | 1 |
| Solas, M | 1 |
| Chen, CY | 1 |
| Leu, HB | 1 |
| Wang, SC | 1 |
| Tsai, SH | 1 |
| Chou, RH | 1 |
| Lu, YW | 1 |
| Tsai, YL | 1 |
| Kuo, CS | 1 |
| Huang, PH | 1 |
| Chen, JW | 1 |
| Lin, SJ | 1 |
| Badran, M | 1 |
| Khalyfa, A | 1 |
| Ericsson, AC | 1 |
| Puech, C | 1 |
| McAdams, Z | 1 |
| Bender, SB | 1 |
| Gozal, D | 1 |
| Zhou, D | 2 |
| Zhang, J | 4 |
| Xiao, C | 1 |
| Mo, C | 1 |
| Ding, BS | 1 |
| Zarbock, KR | 1 |
| Han, JH | 1 |
| Singh, AP | 1 |
| Thomas, SP | 1 |
| Bendlin, BB | 1 |
| Denu, JM | 1 |
| Yu, JJ | 1 |
| Rey, FE | 2 |
| Ulland, TK | 1 |
| Qiao, CM | 1 |
| Quan, W | 1 |
| Zhou, Y | 1 |
| Niu, GY | 1 |
| Hong, H | 2 |
| Wu, J | 1 |
| Zhao, LP | 1 |
| Li, T | 1 |
| Cui, C | 1 |
| Zhao, WJ | 1 |
| Shen, YQ | 1 |
| Gao, Q | 1 |
| Wang, Y | 3 |
| Wang, X | 3 |
| Fu, S | 1 |
| Wang, RT | 2 |
| Prokopienko, AJ | 1 |
| West, RE | 1 |
| Schrum, DP | 1 |
| Stubbs, JR | 1 |
| Leblond, FA | 1 |
| Pichette, V | 1 |
| Nolin, TD | 1 |
| Wu, D | 1 |
| Cao, M | 1 |
| Li, N | 3 |
| Zhang, A | 1 |
| Yu, Z | 1 |
| Cheng, J | 1 |
| Xie, X | 1 |
| Wang, Z | 6 |
| Lu, S | 1 |
| Yan, S | 1 |
| Zhou, J | 1 |
| Peng, J | 1 |
| Zhao, J | 1 |
| Yang, P | 1 |
| Liu, X | 1 |
| Lu, L | 1 |
| Chen, Y | 2 |
| Zhong, X | 1 |
| Li, Z | 3 |
| Liu, H | 3 |
| Ou, C | 2 |
| Yan, J | 2 |
| Chen, M | 2 |
| Wu, T | 2 |
| Gao, Y | 2 |
| Hao, J | 1 |
| Geng, J | 2 |
| Yin, J | 1 |
| Liu, R | 1 |
| Sui, W | 1 |
| Gong, L | 1 |
| Zhang, M | 1 |
| Wang, G | 1 |
| Kong, B | 1 |
| Shuai, W | 1 |
| Fu, H | 1 |
| Jiang, X | 1 |
| Huang, H | 1 |
| Liu, J | 2 |
| Zhang, T | 1 |
| Si, C | 1 |
| Lv, Z | 2 |
| Gupta, N | 2 |
| Buffa, JA | 2 |
| Roberts, AB | 2 |
| Sangwan, N | 1 |
| Skye, SM | 2 |
| Li, L | 3 |
| Ho, KJ | 1 |
| Varga, J | 1 |
| DiDonato, JA | 2 |
| Tang, WHW | 4 |
| Hazen, SL | 8 |
| Koay, YC | 1 |
| Chen, YC | 1 |
| Wali, JA | 1 |
| Luk, AWS | 1 |
| Li, M | 1 |
| Doma, H | 1 |
| Reimark, R | 1 |
| Zaldivia, MTK | 1 |
| Habtom, HT | 1 |
| Franks, AE | 1 |
| Fusco-Allison, G | 1 |
| Yang, J | 2 |
| Holmes, A | 1 |
| Simpson, SJ | 1 |
| Peter, K | 1 |
| O'Sullivan, JF | 1 |
| Organ, CL | 2 |
| Sharp, TE | 1 |
| Polhemus, DJ | 2 |
| Goodchild, TT | 1 |
| Lefer, DJ | 2 |
| Papandreou, C | 1 |
| Moré, M | 1 |
| Bellamine, A | 2 |
| Witkowski, M | 1 |
| Weeks, TL | 1 |
| Chen, L | 1 |
| Jin, Y | 1 |
| Wang, N | 1 |
| Yuan, M | 1 |
| Lin, T | 1 |
| Lu, W | 1 |
| Wang, T | 1 |
| Lu, D | 1 |
| Zhang, H | 1 |
| Shan, Q | 1 |
| Zhou, B | 1 |
| Shan, X | 1 |
| Tu, Q | 1 |
| Chen, J | 1 |
| Yang, Y | 3 |
| Miikeda, A | 2 |
| Zuckerman, J | 1 |
| Jia, X | 2 |
| Charugundla, S | 1 |
| Zhou, Z | 1 |
| Kaczor-Urbanowicz, KE | 1 |
| Magyar, C | 1 |
| Guo, F | 1 |
| Pellegrini, M | 1 |
| Nicholas, SB | 1 |
| Lusis, AJ | 3 |
| Shih, DM | 3 |
| Ma, R | 1 |
| Fu, W | 1 |
| Hu, X | 1 |
| Jiang, H | 2 |
| Li, X | 4 |
| Su, C | 1 |
| Jiang, Z | 2 |
| Yang, M | 1 |
| Du, Y | 2 |
| Wang, L | 2 |
| Jiang, J | 1 |
| Hong, B | 1 |
| Shi, W | 1 |
| Huang, Y | 1 |
| Yang, Z | 1 |
| Yu, B | 1 |
| Mao, J | 1 |
| Zhao, P | 1 |
| Wang, Q | 2 |
| Chen, A | 1 |
| Liu, T | 1 |
| Tao, Z | 1 |
| Gong, M | 1 |
| Song, L | 1 |
| Shi, H | 1 |
| Li, DY | 1 |
| Chen, ML | 1 |
| Zhu, XH | 1 |
| Ran, L | 1 |
| Lang, HD | 1 |
| Yi, L | 1 |
| Mi, MT | 1 |
| Trenteseaux, C | 1 |
| Gaston, AT | 1 |
| Poupeau, G | 1 |
| de Coppet, P | 1 |
| Andriantsitohaina, R | 1 |
| Laschet, J | 1 |
| Amarger, V | 1 |
| Krempf, M | 1 |
| Nobecourt-Dupuy, E | 1 |
| Sun, G | 1 |
| Yin, Z | 1 |
| Liu, N | 1 |
| Bian, X | 1 |
| Yu, R | 1 |
| Su, X | 1 |
| Zhang, B | 1 |
| Yang, C | 1 |
| Wang, B | 1 |
| Hu, T | 1 |
| Gu, Y | 1 |
| Li, J | 3 |
| Ke, Y | 1 |
| Li, D | 2 |
| Zhao, M | 1 |
| Liu, C | 1 |
| Zeng, A | 1 |
| Shi, X | 1 |
| Cheng, S | 1 |
| Pan, B | 1 |
| Zheng, L | 2 |
| Li, XS | 1 |
| Cajka, T | 1 |
| Nemet, I | 1 |
| Hurd, AG | 1 |
| Gu, X | 1 |
| Wu, Y | 2 |
| Shahen, CJ | 1 |
| Wagner, MA | 1 |
| Hartiala, JA | 1 |
| Kerby, RL | 1 |
| Romano, KA | 1 |
| Han, Y | 1 |
| Obeid, S | 1 |
| Lüscher, TF | 1 |
| Allayee, H | 2 |
| Fiehn, O | 1 |
| Lindskog Jonsson, A | 1 |
| Caesar, R | 1 |
| Akrami, R | 1 |
| Reinhardt, C | 1 |
| Fåk Hållenius, F | 1 |
| Borén, J | 1 |
| Bäckhed, F | 1 |
| Wu, Z | 1 |
| Liu, Q | 2 |
| Deng, Y | 1 |
| Coffey, AR | 1 |
| Kanke, M | 1 |
| Smallwood, TL | 1 |
| Albright, J | 1 |
| Pitman, W | 1 |
| Gharaibeh, RZ | 1 |
| Hua, K | 1 |
| Gertz, E | 1 |
| Biddinger, SB | 1 |
| Temel, RE | 1 |
| Pomp, D | 1 |
| Sethupathy, P | 1 |
| Bennett, BJ | 1 |
| Skrzypecki, J | 2 |
| Huc, T | 1 |
| Ciepiaszuk, K | 1 |
| Ufnal, M | 2 |
| Tang, J | 1 |
| Meng, F | 1 |
| Song, B | 1 |
| Zhu, W | 2 |
| Schugar, RC | 1 |
| Meng, Y | 2 |
| Zieger, M | 1 |
| Lee, R | 1 |
| Graham, M | 1 |
| Cantor, RM | 1 |
| Mueller, C | 1 |
| Brown, JM | 1 |
| Zhao, ZH | 1 |
| Xin, FZ | 1 |
| Xue, YQ | 1 |
| Liu, XL | 1 |
| Yang, RX | 1 |
| Pan, Q | 1 |
| Fan, JG | 1 |
| Weng, Z | 1 |
| Shao, W | 1 |
| Guo, W | 1 |
| Chen, C | 1 |
| Jiao, L | 1 |
| Lu, Q | 1 |
| Sun, H | 1 |
| Gu, A | 1 |
| Hu, H | 1 |
| Yang, W | 1 |
| Zhang, S | 1 |
| Zhu, J | 1 |
| Jia, D | 1 |
| Ou, T | 1 |
| Qi, Z | 1 |
| Zou, Y | 1 |
| Qian, J | 1 |
| Sun, A | 1 |
| Ge, J | 1 |
| Liu, Y | 1 |
| Yuan, F | 1 |
| Guo, J | 1 |
| Jazwiec, R | 1 |
| Dadlez, M | 1 |
| Drapala, A | 1 |
| Sikora, M | 1 |
| Moraes, C | 1 |
| Fouque, D | 1 |
| Amaral, AC | 1 |
| Mafra, D | 1 |
| Yazdekhasti, N | 1 |
| Brandsch, C | 1 |
| Schmidt, N | 1 |
| Schloesser, A | 1 |
| Huebbe, P | 1 |
| Rimbach, G | 1 |
| Stangl, GI | 1 |
| Collins, HL | 1 |
| Drazul-Schrader, D | 1 |
| Sulpizio, AC | 1 |
| Koster, PD | 1 |
| Williamson, Y | 1 |
| Adelman, SJ | 1 |
| Owen, K | 1 |
| Sanli, T | 1 |
| Otsuka, H | 1 |
| Bhushan, S | 1 |
| Bradley, J | 1 |
| Trivedi, R | 1 |
| Tang, WH | 1 |
| Seldin, MM | 1 |
| Qi, H | 1 |
| Dambrova, M | 1 |
| Latkovskis, G | 1 |
| Kuka, J | 1 |
| Strele, I | 1 |
| Konrade, I | 1 |
| Grinberga, S | 1 |
| Hartmane, D | 1 |
| Pugovics, O | 1 |
| Erglis, A | 1 |
| Liepinsh, E | 1 |
| Al-Ani, B | 1 |
| Fitzpatrick, M | 1 |
| Al-Nuaimi, H | 1 |
| Coughlan, AM | 1 |
| Hickey, FB | 1 |
| Pusey, CD | 1 |
| Savage, C | 1 |
| Benton, CM | 1 |
| O'Brien, EC | 1 |
| O'Toole, D | 1 |
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| Yang, JY | 1 |
| Kwack, SJ | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Lp299v on Vascular Aging in Healthy Adults[NCT05296395] | 20 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 reviews available for trimethyloxamine and Disease Models, Animal
| Article | Year |
|---|---|
Trimethylamine N-Oxide in Relation to Cardiometabolic Health-Cause or Effect?
Topics: Age Factors; Amines; Animals; Cardiometabolic Risk Factors; Cardiovascular Diseases; Carnitine; Dige | 2020 |
Gut Microbiota and Cardiovascular Disease.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cardiovascular Diseases; Carnitine; Choline; Disease | 2020 |
Gut Microbiota and Atherosclerosis.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Carnitine; Diet; Disease Models, Animal; Gastrointes | 2017 |
Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet.
Topics: Animals; Cardiovascular Diseases; Carnitine; Choline; Diet, Protein-Restricted; Disease Models, Anim | 2015 |
58 other studies available for trimethyloxamine and Disease Models, Animal
| Article | Year |
|---|---|
Chlorogenic acid inhibits trimethylamine-
Topics: Animal Feed; Animals; Carnitine; Chlorogenic Acid; Disease Models, Animal; Gastrointestinal Microbio | 2021 |
Perinatal Administration of C-Phycocyanin Protects Against Atherosclerosis in apoE-Deficient Mice by Modulating Cholesterol and Trimethylamine-N-Oxide Metabolisms.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cholesterol; Disease Models, Animal; Female; Male; Meth | 2021 |
Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytokines; Disease Models, Animal; | 2022 |
Trimethylamine N-oxide promotes atherosclerosis via regulating the enriched abundant transcript 1/miR-370-3p/signal transducer and activator of transcription 3/flavin-containing monooxygenase-3 axis.
Topics: Aged; Animals; Atherosclerosis; Case-Control Studies; Diet, High-Fat; Disease Models, Animal; Feedba | 2022 |
Trimethylamine N-Oxide Promotes Abdominal Aortic Aneurysm Formation by Aggravating Aortic Smooth Muscle Cell Senescence in Mice.
Topics: Angiotensin II; Animals; Aorta, Abdominal; Aortic Aneurysm, Abdominal; Calcium Chloride; Disease Mod | 2022 |
Diet-Induced High Serum Levels of Trimethylamine-N-oxide Enhance the Cellular Inflammatory Response without Exacerbating Acute Intracerebral Hemorrhage Injury in Mice.
Topics: Acute Disease; Animals; Astrocytes; Brain Injuries; Cerebral Hemorrhage; Choline; Diet; Disease Mode | 2022 |
Trimethylamine N-oxide (TMAO) drives insulin resistance and cognitive deficiencies in a senescence accelerated mouse model.
Topics: Animals; Cognition; Dementia; Disease Models, Animal; Dysbiosis; Gastrointestinal Microbiome; Insuli | 2022 |
Inhibition of Trimethylamine N-Oxide Attenuates Neointimal Formation Through Reduction of Inflammasome and Oxidative Stress in a Mouse Model of Carotid Artery Ligation.
Topics: Animals; Atherosclerosis; Carotid Arteries; Choline; Disease Models, Animal; Humans; Inflammasomes; | 2023 |
Gut microbiota mediate vascular dysfunction in a murine model of sleep apnoea: effect of probiotics.
Topics: Animals; Coronary Artery Disease; Disease Models, Animal; Gastrointestinal Microbiome; Hypoxia; Mice | 2023 |
Trimethylamine-N-oxide (TMAO) mediates the crosstalk between the gut microbiota and hepatic vascular niche to alleviate liver fibrosis in nonalcoholic steatohepatitis.
Topics: Animals; Disease Models, Animal; Gastrointestinal Microbiome; Liver Cirrhosis; Methylamines; Mice; N | 2022 |
Trimethylamine N-Oxide Reduces Neurite Density and Plaque Intensity in a Murine Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Mice; Mice, Transgenic; N | 2022 |
Orally Induced High Serum Level of Trimethylamine N-oxide Worsened Glial Reaction and Neuroinflammation on MPTP-Induced Acute Parkinson's Disease Model Mice.
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Disease Models, Animal; Dopamine; Dopaminergi | 2023 |
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cognition; Disease Models, Anim | 2019 |
Metabolic Activation of Flavin Monooxygenase-mediated Trimethylamine-N-Oxide Formation in Experimental Kidney Disease.
Topics: Activation, Metabolic; Animals; Blood Urea Nitrogen; Creatinine; Cytochrome P-450 CYP1A2; Disease Mo | 2019 |
Effect of trimethylamine N-oxide on inflammation and the gut microbiota in Helicobacter pylori-infected mice.
Topics: Animals; Cell Line; Disease Models, Animal; DNA, Bacterial; Escherichia; Feeding Behavior; Female; G | 2020 |
Trimethylamine-N-Oxide Promotes Vascular Calcification Through Activation of NLRP3 (Nucleotide-Binding Domain, Leucine-Rich-Containing Family, Pyrin Domain-Containing-3) Inflammasome and NF-κB (Nuclear Factor κB) Signals.
Topics: Adult; Aged; Animals; Anti-Bacterial Agents; Aorta, Thoracic; Cells, Cultured; Disease Models, Anima | 2020 |
Capsanthin extract prevents obesity, reduces serum TMAO levels and modulates the gut microbiota composition in high-fat-diet induced obese C57BL/6J mice.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Male; Methylamines; Mi | 2020 |
3,3-Dimethyl-1-butanol attenuates cardiac remodeling in pressure-overload-induced heart failure mice.
Topics: Animals; Cardiomegaly; Disease Models, Animal; Echocardiography; Electrocardiography; Fibroblasts; H | 2020 |
Baicalin ameliorates neuropathology in repeated cerebral ischemia-reperfusion injury model mice by remodeling the gut microbiota.
Topics: Animals; Brain; Clusterin; Cytokines; Disease Models, Animal; Flavonoids; Gastrointestinal Microbiom | 2020 |
Targeted Inhibition of Gut Microbial Trimethylamine N-Oxide Production Reduces Renal Tubulointerstitial Fibrosis and Functional Impairment in a Murine Model of Chronic Kidney Disease.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; | 2020 |
Plasma levels of trimethylamine-N-oxide can be increased with 'healthy' and 'unhealthy' diets and do not correlate with the extent of atherosclerosis but with plaque instability.
Topics: Animal Feed; Animals; Atherosclerosis; Bacteria; Biomarkers; Carotid Artery Diseases; Choline; Coron | 2021 |
Nonlethal Inhibition of Gut Microbial Trimethylamine N-oxide Production Improves Cardiac Function and Remodeling in a Murine Model of Heart Failure.
Topics: Animals; Bacteria; Bacterial Proteins; Choline; Disease Models, Animal; Down-Regulation; Enzyme Inhi | 2020 |
Trimethylamine N-oxide impairs perfusion recovery after hindlimb ischemia.
Topics: Animals; Blood Circulation; Disease Models, Animal; Hindlimb; Human Umbilical Vein Endothelial Cells | 2020 |
Renal denervation improves chronic intermittent hypoxia induced hypertension and cardiac fibrosis and balances gut microbiota.
Topics: Animals; Blood Pressure; Cardiomyopathies; Denervation; Disease Models, Animal; Fibrosis; Gastrointe | 2020 |
Ginkgolide B treatment regulated intestinal flora to improve high-fat diet induced atherosclerosis in ApoE
Topics: Animals; Atherosclerosis; Bacteroides; Diet, High-Fat; Disease Models, Animal; Fibrinolytic Agents; | 2021 |
Inhibition of microbiota-dependent TMAO production attenuates chronic kidney disease in mice.
Topics: Adenine; Albuminuria; Animals; Cardiomegaly; Choline; Disease Models, Animal; Female; Fibroblast Gro | 2021 |
TMAO: a potential mediator of clopidogrel resistance.
Topics: Animals; Biomarkers; Blood Platelets; Clopidogrel; Coronary Artery Disease; Disease Models, Animal; | 2021 |
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome.
Topics: Animals; Atherosclerosis; Berberine; Choline; Diet; Disease Models, Animal; Disease Susceptibility; | 2021 |
Reduction of TMAO level enhances the stability of carotid atherosclerotic plaque through promoting macrophage M2 polarization and efferocytosis.
Topics: Animals; Carotid Arteries; Carotid Artery Diseases; Disease Models, Animal; Down-Regulation; Enzyme | 2021 |
Repeated 3,3-Dimethyl-1-butanol exposure alters social dominance in adult mice.
Topics: Animals; Anxiety; Behavior Observation Techniques; Behavior, Animal; Brain-Gut Axis; Depression; Dis | 2021 |
Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway.
Topics: Animals; Antioxidants; Apoptosis Regulatory Proteins; Atherosclerosis; Cells, Cultured; Disease Mode | 2017 |
Perinatal Hypercholesterolemia Exacerbates Atherosclerosis Lesions in Offspring by Altering Metabolism of Trimethylamine-N-Oxide and Bile Acids.
Topics: Age Factors; Animals; Animals, Newborn; Aorta; Aortic Diseases; Apolipoproteins E; Atherosclerosis; | 2017 |
Gut microbial metabolite TMAO contributes to renal dysfunction in a mouse model of diet-induced obesity.
Topics: Animals; Diet, High-Fat; Disease Models, Animal; Gastrointestinal Microbiome; Hemodynamics; Inflamma | 2017 |
Trimethylamine N-oxide promotes atherosclerosis via CD36-dependent MAPK/JNK pathway.
Topics: Animals; Apolipoproteins E; Atherosclerosis; CD36 Antigens; Cytokines; Disease Models, Animal; Disea | 2018 |
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; beta-Galactosidase; Blood Proteins; Cell | 2018 |
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo | 2018 |
Impact of Gut Microbiota and Diet on the Development of Atherosclerosis in Apoe
Topics: Animal Feed; Animals; Aortic Diseases; Atherosclerosis; Bacteria; Cholesterol; Choline; Diet, Wester | 2018 |
Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis.
Topics: Animals; Cardiomegaly; Cells, Cultured; Disease Models, Animal; Fibrosis; Gastrointestinal Microbiom | 2019 |
microRNA-146a-5p association with the cardiometabolic disease risk factor TMAO.
Topics: Animals; Atherosclerosis; Chlorocebus aethiops; Choline; Cohort Studies; Collaborative Cross Mice; D | 2019 |
Effect of TMAO, a Gut-Bacteria Metabolite, on Dry Eye in a Rat Model.
Topics: Administration, Ophthalmic; Animals; Blinking; Disease Models, Animal; Dry Eye Syndromes; Female; Fl | 2019 |
Increased circulating trimethylamine N-oxide plays a contributory role in the development of endothelial dysfunction and hypertension in the RUPP rat model of preeclampsia.
Topics: Animals; Disease Models, Animal; Endothelium, Vascular; Female; Hexanols; Inflammation; Interleukin- | 2019 |
The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats.
Topics: Age Factors; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Gastrointestinal Microbi | 2019 |
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
Topics: Animals; Atherosclerosis; Choline; Disease Models, Animal; Lipid Metabolism; Methylamines; Mice; Mic | 2019 |
Trimethylamine N-oxide attenuates high-fat high-cholesterol diet-induced steatohepatitis by reducing hepatic cholesterol overload in rats.
Topics: Administration, Oral; Animals; Cholesterol, Dietary; Diet, High-Fat; Disease Models, Animal; Disease | 2019 |
FMO3 and its metabolite TMAO contribute to the formation of gallstones.
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Casse | 2019 |
Gut microbe-derived metabolite trimethylamine N-oxide accelerates fibroblast-myofibroblast differentiation and induces cardiac fibrosis.
Topics: Animals; Cell Differentiation; Collagen Type I; Disease Models, Animal; Fibroblasts; Fibrosis; Gastr | 2019 |
Serum metabonomic analysis of apoE(-/-) mice reveals progression axes for atherosclerosis based on NMR spectroscopy.
Topics: Animals; Atherosclerosis; Biomarkers; Cholesterol, HDL; Cholesterol, LDL; Choline; Diet, High-Fat; D | 2014 |
Trimethylamine-N-oxide: a carnitine-derived metabolite that prolongs the hypertensive effect of angiotensin II in rats.
Topics: Angiotensin II; Animals; Blood Pressure; Chromatography, High Pressure Liquid; Disease Models, Anima | 2014 |
Fish protein increases circulating levels of trimethylamine-N-oxide and accelerates aortic lesion formation in apoE null mice.
Topics: Animals; Aorta, Thoracic; Apolipoproteins E; Atherosclerosis; Disease Models, Animal; Fish Proteins; | 2016 |
L-Carnitine intake and high trimethylamine N-oxide plasma levels correlate with low aortic lesions in ApoE(-/-) transgenic mice expressing CETP.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Carnitine; Cells, Cultured; Cholesterol Ester Transfer | 2016 |
Choline Diet and Its Gut Microbe-Derived Metabolite, Trimethylamine N-Oxide, Exacerbate Pressure Overload-Induced Heart Failure.
Topics: Animals; Bacteria; Cardiomegaly; Choline; Diet; Disease Models, Animal; Disease Progression; Fibrosi | 2016 |
Trimethylamine N-Oxide Promotes Vascular Inflammation Through Signaling of Mitogen-Activated Protein Kinase and Nuclear Factor-κB.
Topics: Animals; Aorta; Aortitis; Atherosclerosis; Cell Adhesion; Cells, Cultured; Choline; Coculture Techni | 2016 |
Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels.
Topics: Age Factors; Aged; Animals; Body Mass Index; Cardiovascular Diseases; Carnitine; Diabetes Mellitus; | 2016 |
Changes in urinary metabolomic profile during relapsing renal vasculitis.
Topics: Animals; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Citric Acid; Disease Models, An | 2016 |
Toxicometabolomics of urinary biomarkers for human gastric cancer in a mouse model.
Topics: Adenocarcinoma; Animals; Biomarkers, Tumor; Cell Line, Tumor; Citric Acid; Discriminant Analysis; Di | 2010 |
Investigations into biochemical changes of genetic hypertensive rats using 1H nuclear magnetic resonance-based metabonomics.
Topics: Animals; Citric Acid; Creatine; Creatinine; Dimethylamines; Disease Models, Animal; Hypertension; Ke | 2005 |
Cellular osmolytes reduce lens epithelial cell death and alleviate cataract formation in galactosemic rats.
Topics: Animals; Body Weight; Cataract; Cell Death; Cell Survival; Cells, Cultured; Disease Models, Animal; | 2007 |
Trimetazidine reduces renal dysfunction by limiting the cold ischemia/reperfusion injury in autotransplanted pig kidneys.
Topics: Animals; Cold Temperature; Dimethylamines; Disease Models, Animal; Graft Rejection; Graft Survival; | 2000 |