trimethyloxamine has been researched along with Diabetic Glomerulosclerosis in 7 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
| Excerpt | Relevance | Reference |
|---|---|---|
| " More specifically, we review data on the following: (i) tryptophan metabolites and chronic kidney disease onset, illustrating the interpretation of metabolite data in the context of established biochemical pathways; (ii) trimethylamine-N-oxide and cardiovascular disease in chronic kidney disease, illustrating the integration of exogenous and endogenous inputs to the blood metabolome; and (iii) renal mitochondrial function in diabetic kidney disease and acute kidney injury, illustrating the potential for rapid translation of metabolite data for diagnostic or therapeutic aims." | 4.95 | An overview of renal metabolomics. ( Kalim, S; Rhee, EP, 2017) |
| "Nowadays, diabetic kidney disease (DKD) has become one of the most threatening to the end-stage renal diseases, and the early prevention of DKD is inevitable for Diabetes Mellitus (DM) patients." | 1.91 | Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: Intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis. ( Huang, JH; Hui, BP; Lin, QX; Liu, X; Liu, Z; Peng, YJ; Wang, Y; Xie, J; Yi, ZY; Yu, R; Zhang, SH; Zhao, D, 2023) |
| "This case-cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1." | 1.91 | Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. ( Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X, 2023) |
| "In individuals with type 1 diabetes, higher concentrations of plasma TMAO were associated with mortality, CVD events, and poor renal outcome, independent of conventional risk factors." | 1.51 | Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes. ( Ahluwalia, TS; Hansen, TW; Hazen, SL; Jorsal, A; Parving, HH; Pedersen, O; Rossing, P; Tarnow, L; Theilade, S; Tofte, N; Wang, Z; Winther, SA; Øllgaard, JC, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 5 (71.43) | 2.80 |
| Authors | Studies |
|---|---|
| Sapa, H | 2 |
| Gutiérrez, OM | 1 |
| Shlipak, MG | 2 |
| Katz, R | 1 |
| Ix, JH | 2 |
| Sarnak, MJ | 1 |
| Cushman, M | 1 |
| Rhee, EP | 2 |
| Kimmel, PL | 2 |
| Vasan, RS | 2 |
| Schrauben, SJ | 2 |
| Feldman, HI | 2 |
| Seegmiller, JC | 2 |
| Brunengraber, H | 2 |
| Hostetter, TH | 2 |
| Schelling, JR | 2 |
| Yang, M | 1 |
| Zhang, R | 1 |
| Zhuang, C | 1 |
| Wu, Y | 1 |
| Yang, Q | 1 |
| Yu, Z | 1 |
| Liu, J | 1 |
| Zha, B | 1 |
| Gong, Q | 1 |
| Yang, B | 1 |
| Zeng, M | 1 |
| Yan, C | 1 |
| Yi, ZY | 1 |
| Peng, YJ | 1 |
| Hui, BP | 1 |
| Liu, Z | 1 |
| Lin, QX | 1 |
| Zhao, D | 1 |
| Wang, Y | 1 |
| Liu, X | 1 |
| Xie, J | 1 |
| Zhang, SH | 1 |
| Huang, JH | 1 |
| Yu, R | 1 |
| Xie, D | 1 |
| Zhang, X | 1 |
| Anderson, AH | 1 |
| Hsu, CY | 1 |
| Shafi, T | 1 |
| Mehta, R | 1 |
| Bhat, Z | 1 |
| Brown, J | 1 |
| Charleston, J | 1 |
| Chen, J | 1 |
| He, J | 1 |
| Rao, P | 1 |
| Townsend, R | 1 |
| Fang, Q | 1 |
| Liu, N | 1 |
| Zheng, B | 1 |
| Guo, F | 1 |
| Zeng, X | 1 |
| Huang, X | 1 |
| Ouyang, D | 1 |
| Winther, SA | 1 |
| Øllgaard, JC | 1 |
| Tofte, N | 1 |
| Tarnow, L | 1 |
| Wang, Z | 1 |
| Ahluwalia, TS | 1 |
| Jorsal, A | 1 |
| Theilade, S | 1 |
| Parving, HH | 1 |
| Hansen, TW | 1 |
| Hazen, SL | 1 |
| Pedersen, O | 1 |
| Rossing, P | 1 |
| Kalim, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714] | Phase 1/Phase 2 | 60 participants (Anticipated) | Interventional | 2023-11-01 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for trimethyloxamine and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Roles of Gut Microbial Metabolites in Diabetic Kidney Disease.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fatty Acids, Volatile; Gastrointestinal | 2021 |
An overview of renal metabolomics.
Topics: Acute Kidney Injury; Analytic Sample Preparation Methods; Cardiovascular Diseases; Diabetic Nephropa | 2017 |
5 other studies available for trimethyloxamine and Diabetic Glomerulosclerosis
| Article | Year |
|---|---|
Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diabetic Nephropathies; Humans; Me | 2022 |
Serum Trimethylamine N-oxide and the Diversity of the Intestinal Microbial Flora in Type 2 Diabetes Complicated by Diabetic Kidney Disease.
Topics: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Male; Methylamines; Peptides; Sco | 2022 |
Zuogui-Jiangtang-Yishen decoction prevents diabetic kidney disease: Intervene pyroptosis induced by trimethylamine n-oxide through the mROS-NLRP3 axis.
Topics: Animals; Chromatography, Liquid; Diabetes Mellitus; Diabetic Nephropathies; Drugs, Chinese Herbal; H | 2023 |
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; D | 2023 |
Utility of Plasma Concentration of Trimethylamine N-Oxide in Predicting Cardiovascular and Renal Complications in Individuals With Type 1 Diabetes.
Topics: Aged; Biomarkers; Diabetes Mellitus, Type 1; Diabetic Cardiomyopathies; Diabetic Nephropathies; Fema | 2019 |