trimethyloxamine has been researched along with Diabetes Mellitus, Type 2 in 34 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We examined associations of weight loss diet-induced changes in a gut microbiota-related metabolite trimethylamine N-oxide (TMAO), and its precursors (choline and l-carnitine), with changes in bone mineral density (BMD) considering diabetes-related factors." | 5.30 | Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial. ( Bray, GA; Chen, Y; DiDonato, JA; Heianza, Y; LeBoff, MS; Li, X; Pei, X; Qi, L; Sacks, FM; Sun, D; Zhou, T, 2019) |
| " We examined associations of 6-month changes in blood metabolites (TMAO, choline, and l-carnitine) with improvements in body weight (BW), waist circumference (WC), body fat composition, fat distribution, and resting energy expenditure (REE)." | 5.27 | Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial. ( Bray, GA; Heianza, Y; Qi, L; Sacks, FM; Smith, SR; Sun, D, 2018) |
| "The relationship between sodium glucose co-transporter 2 inhibitors (SGLT2i) and trimethylamine N-oxide (TMAO) following acute myocardial infarction (AMI) is not yet explored." | 4.31 | Alterations in trimethylamine-N-oxide in response to Empagliflozin therapy: a secondary analysis of the EMMY trial. ( Aziz, F; Curcic, P; Hermann, M; Kolesnik, E; Mangge, H; Meinitzer, A; Pferschy, PN; Sourij, H; Tripolt, NJ; von Lewinski, D, 2023) |
| "Trimethylamine N-oxide (TMAO) and phenylacetylglutamine (PAGln) are associated with acute myocardial infarction (AMI) and type 2 diabetes mellitus (T2DM)." | 4.12 | Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spectrometry method. ( Cui, J; Ma, X; Qiu, L; Tang, Y; Yu, S; Zhang, L; Zou, Y, 2022) |
| "Trimethylamine N-oxide (TMAO), choline and betaine serum levels have been associated with metabolic diseases including type 2 diabetes (T2D) and non-alcoholic fatty liver disease (NAFLD)." | 4.02 | Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes. ( Aguilar-Salinas, C; Campos-Pérez, F; Canizales-Quinteros, S; Gómez-Pérez, F; González-González, I; Grandini-Rosales, P; Hazen, SL; Hernández-Pando, R; Huertas-Vazquez, A; Hui, ST; Larrieta-Carrasco, E; León-Mimila, P; Li, XS; López-Contreras, B; Lusis, AJ; Macías-Kauffer, L; Morán-Ramos, S; Ocampo-Medina, E; Olivares-Arevalo, M; Shih, DM; Villamil-Ramírez, H; Villarreal-Molina, T; Wang, Z, 2021) |
| "Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite generated from its dietary precursors such as choline, has been identified as an independent risk factor for atherosclerosis." | 4.02 | Metformin alleviates choline diet-induced TMAO elevation in C57BL/6J mice by influencing gut-microbiota composition and functionality. ( Du, Y; Hong, B; Li, X; Su, C; Wang, L; Yang, Y; Zhang, X, 2021) |
| " We aimed to synthesize the evidence on the relation between TMAO levels and the risk of diabetes mellitus (DM) and to investigate the association further in a dose-response meta-analysis." | 2.61 | Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis. ( Fan, H; Ge, X; Gong, X; Han, L; Liu, Z; Meng, Q; Yu, P; Zhang, Y; Zheng, L; Zhou, X; Zhuang, R, 2019) |
| "Blood samples were obtained from 122 type 2 diabetes mellitus (T2DM) patients with or without DR." | 1.62 | Elevated plasma trimethylamine-N-oxide levels are associated with diabetic retinopathy. ( Gu, Y; Li, X; Liu, G; Liu, W; Lu, P; Ren, C; Wang, C; Xia, W; Xia, Y, 2021) |
| "Betaine is a major osmolyte, also important in methyl group metabolism." | 1.40 | Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. ( Atkinson, W; Bellamy, D; Chambers, ST; Elmslie, JL; Frampton, CM; George, PM; Ho, M; Lever, M; McEntyre, CJ; Molyneux, SL; Richards, AM; Slow, S; Troughton, RW; Young, JM, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 14 (41.18) | 24.3611 |
| 2020's | 20 (58.82) | 2.80 |
| Authors | Studies |
|---|---|
| Krueger, ES | 1 |
| Beales, JL | 1 |
| Russon, KB | 1 |
| Elison, WS | 1 |
| Davis, JR | 1 |
| Hansen, JM | 2 |
| Neilson, AP | 1 |
| Tessem, JS | 1 |
| Yang, M | 1 |
| Zhang, R | 1 |
| Zhuang, C | 1 |
| Wu, Y | 2 |
| Yang, Q | 1 |
| Yu, Z | 1 |
| Liu, J | 1 |
| Zha, B | 1 |
| Gong, Q | 1 |
| Yang, B | 1 |
| Zeng, M | 1 |
| Yan, C | 1 |
| Kalagi, NA | 1 |
| Thota, RN | 1 |
| Stojanovski, E | 1 |
| Alburikan, KA | 1 |
| Garg, ML | 1 |
| Jiang, WY | 1 |
| Huo, JY | 1 |
| Wang, SC | 1 |
| Cheng, YD | 1 |
| Lyu, YT | 1 |
| Jiang, ZX | 1 |
| Shan, QJ | 1 |
| Zou, H | 1 |
| Huang, C | 1 |
| Zhou, L | 1 |
| Lu, R | 1 |
| Zhang, Y | 3 |
| Lin, D | 1 |
| Tang, Y | 1 |
| Zou, Y | 1 |
| Cui, J | 1 |
| Ma, X | 1 |
| Zhang, L | 1 |
| Yu, S | 1 |
| Qiu, L | 1 |
| Sánchez-Quintero, MJ | 1 |
| Delgado, J | 1 |
| Medina-Vera, D | 1 |
| Becerra-Muñoz, VM | 1 |
| Queipo-Ortuño, MI | 1 |
| Estévez, M | 1 |
| Plaza-Andrades, I | 1 |
| Rodríguez-Capitán, J | 1 |
| Sánchez, PL | 1 |
| Crespo-Leiro, MG | 1 |
| Jiménez-Navarro, MF | 1 |
| Pavón-Morón, FJ | 1 |
| Aziz, F | 1 |
| Tripolt, NJ | 1 |
| Pferschy, PN | 1 |
| Kolesnik, E | 1 |
| Mangge, H | 1 |
| Curcic, P | 1 |
| Hermann, M | 1 |
| Meinitzer, A | 1 |
| von Lewinski, D | 1 |
| Sourij, H | 1 |
| Cardona, A | 1 |
| O'Brien, A | 1 |
| Bernier, MC | 1 |
| Somogyi, A | 1 |
| Wysocki, VH | 1 |
| Smart, S | 1 |
| He, X | 1 |
| Ambrosio, G | 1 |
| Hsueh, WA | 1 |
| Raman, SV | 1 |
| Zhu, T | 1 |
| Goodarzi, MO | 1 |
| Croyal, M | 1 |
| Saulnier, PJ | 1 |
| Aguesse, A | 1 |
| Gand, E | 1 |
| Ragot, S | 1 |
| Roussel, R | 1 |
| Halimi, JM | 1 |
| Ducrocq, G | 1 |
| Cariou, B | 1 |
| Montaigne, D | 1 |
| Wargny, M | 1 |
| Krempf, M | 1 |
| Hadjadj, S | 1 |
| Winther, SA | 2 |
| Rossing, P | 2 |
| León-Mimila, P | 1 |
| Villamil-Ramírez, H | 1 |
| Li, XS | 3 |
| Shih, DM | 2 |
| Hui, ST | 1 |
| Ocampo-Medina, E | 1 |
| López-Contreras, B | 1 |
| Morán-Ramos, S | 1 |
| Olivares-Arevalo, M | 1 |
| Grandini-Rosales, P | 1 |
| Macías-Kauffer, L | 1 |
| González-González, I | 1 |
| Hernández-Pando, R | 1 |
| Gómez-Pérez, F | 1 |
| Campos-Pérez, F | 1 |
| Aguilar-Salinas, C | 1 |
| Larrieta-Carrasco, E | 1 |
| Villarreal-Molina, T | 1 |
| Wang, Z | 5 |
| Lusis, AJ | 3 |
| Hazen, SL | 4 |
| Huertas-Vazquez, A | 1 |
| Canizales-Quinteros, S | 1 |
| Kumari, A | 1 |
| Sharma, R | 1 |
| Somvanshi, P | 1 |
| Grover, A | 1 |
| Liu, W | 1 |
| Wang, C | 1 |
| Xia, Y | 1 |
| Xia, W | 1 |
| Liu, G | 1 |
| Ren, C | 1 |
| Gu, Y | 1 |
| Li, X | 3 |
| Lu, P | 1 |
| Fikri, AM | 1 |
| Smyth, R | 1 |
| Kumar, V | 1 |
| Al-Abadla, Z | 1 |
| Abusnana, S | 1 |
| Munday, MR | 1 |
| Argyridou, S | 1 |
| Bernieh, D | 1 |
| Henson, J | 1 |
| Edwardson, CL | 1 |
| Davies, MJ | 1 |
| Khunti, K | 1 |
| Suzuki, T | 1 |
| Yates, T | 1 |
| Kwee, LC | 1 |
| Ilkayeva, O | 1 |
| Muehlbauer, MJ | 1 |
| Bihlmeyer, N | 1 |
| Wolfe, B | 1 |
| Purnell, JQ | 1 |
| Xavier Pi-Sunyer, F | 1 |
| Chen, H | 1 |
| Bahnson, J | 1 |
| Newgard, CB | 1 |
| Shah, SH | 1 |
| Laferrère, B | 1 |
| Øllgaard, JC | 1 |
| Hansen, TW | 1 |
| von Scholten, BJ | 1 |
| Reinhard, H | 1 |
| Ahluwalia, TS | 1 |
| Gæde, P | 1 |
| Parving, HH | 1 |
| Hazen, S | 1 |
| Pedersen, O | 1 |
| Fang, Q | 1 |
| Liu, N | 1 |
| Zheng, B | 1 |
| Guo, F | 1 |
| Zeng, X | 1 |
| Huang, X | 1 |
| Ouyang, D | 1 |
| Su, C | 1 |
| Yang, Y | 1 |
| Du, Y | 1 |
| Zhang, X | 1 |
| Wang, L | 1 |
| Hong, B | 1 |
| Hove-Skovsgaard, M | 1 |
| Gaardbo, JC | 1 |
| Kolte, L | 1 |
| Winding, K | 1 |
| Seljeflot, I | 1 |
| Svardal, A | 2 |
| Berge, RK | 2 |
| Gerstoft, J | 1 |
| Ullum, H | 1 |
| Trøseid, M | 2 |
| Nielsen, SD | 1 |
| Org, E | 1 |
| Blum, Y | 1 |
| Kasela, S | 1 |
| Mehrabian, M | 1 |
| Kuusisto, J | 1 |
| Kangas, AJ | 1 |
| Soininen, P | 1 |
| Ala-Korpela, M | 1 |
| Laakso, M | 2 |
| Schugar, RC | 1 |
| Warrier, M | 1 |
| Helsley, RN | 1 |
| Burrows, A | 1 |
| Ferguson, D | 1 |
| Brown, AL | 1 |
| Gromovsky, AD | 1 |
| Heine, M | 1 |
| Chatterjee, A | 1 |
| Li, L | 1 |
| Willard, B | 1 |
| Meng, Y | 1 |
| Kim, H | 1 |
| Che, N | 1 |
| Pan, C | 1 |
| Lee, RG | 1 |
| Crooke, RM | 1 |
| Graham, MJ | 1 |
| Morton, RE | 1 |
| Langefeld, CD | 1 |
| Das, SK | 1 |
| Rudel, LL | 1 |
| Zein, N | 1 |
| McCullough, AJ | 1 |
| Dasarathy, S | 1 |
| Tang, WHW | 1 |
| Erokwu, BO | 1 |
| Flask, CA | 1 |
| Civelek, M | 1 |
| Naga Prasad, SV | 1 |
| Heeren, J | 1 |
| Brown, JM | 1 |
| Li, H | 1 |
| Qi, T | 1 |
| Huang, ZS | 1 |
| Ying, Y | 1 |
| Wang, B | 1 |
| Ye, L | 1 |
| Zhang, B | 1 |
| Chen, DL | 1 |
| Chen, J | 1 |
| Heianza, Y | 2 |
| Sun, D | 2 |
| Smith, SR | 1 |
| Bray, GA | 2 |
| Sacks, FM | 2 |
| Qi, L | 2 |
| Papandreou, C | 1 |
| Bulló, M | 1 |
| Zheng, Y | 1 |
| Ruiz-Canela, M | 1 |
| Yu, E | 1 |
| Guasch-Ferré, M | 1 |
| Toledo, E | 1 |
| Clish, C | 1 |
| Corella, D | 1 |
| Estruch, R | 1 |
| Ros, E | 1 |
| Fitó, M | 1 |
| Arós, F | 1 |
| Fiol, M | 1 |
| Lapetra, J | 1 |
| Serra-Majem, L | 1 |
| Gómez-Gracia, E | 1 |
| Liang, L | 1 |
| Fragkiadakis, GA | 1 |
| Razquin, C | 1 |
| Hu, FB | 1 |
| Salas-Salvadó, J | 1 |
| Dong, Z | 1 |
| Liang, Z | 1 |
| Guo, M | 1 |
| Hu, S | 1 |
| Shen, Z | 1 |
| Hai, X | 1 |
| Zhuang, R | 1 |
| Ge, X | 1 |
| Han, L | 1 |
| Yu, P | 1 |
| Gong, X | 1 |
| Meng, Q | 1 |
| Fan, H | 1 |
| Zheng, L | 1 |
| Liu, Z | 1 |
| Zhou, X | 1 |
| Zhou, T | 1 |
| Chen, Y | 1 |
| DiDonato, JA | 1 |
| Pei, X | 1 |
| LeBoff, MS | 1 |
| Seeliger, J | 1 |
| Estel, K | 1 |
| Erwin, N | 1 |
| Winter, R | 1 |
| Lever, M | 1 |
| George, PM | 1 |
| Slow, S | 1 |
| Bellamy, D | 1 |
| Young, JM | 1 |
| Ho, M | 1 |
| McEntyre, CJ | 1 |
| Elmslie, JL | 1 |
| Atkinson, W | 1 |
| Molyneux, SL | 1 |
| Troughton, RW | 1 |
| Frampton, CM | 1 |
| Richards, AM | 1 |
| Chambers, ST | 1 |
| Hov, JR | 1 |
| Nestvold, TK | 1 |
| Thoresen, H | 1 |
| Lappegård, KT | 1 |
| Tang, WH | 1 |
| Fan, Y | 1 |
| Li, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Developmental Impacts of MicroPLastics Exposure in Early Life[NCT06107933] | 40 participants (Anticipated) | Observational | 2023-10-01 | Recruiting | |||
| Analysis of MicroBial Metabolites After Eating Refined Food[NCT04308473] | 46 participants (Actual) | Interventional | 2020-09-01 | Active, not recruiting | |||
| Preventing Overweight Using Novel Dietary Strategies (Pounds Lost)[NCT00072995] | 811 participants | Interventional | 2003-09-30 | Completed | |||
| Longitudinal Profiling of Gut Microbiome in Overweight or Obese Participants on a Modified Atkins Diet: a Prospective Cohort Study[NCT04207879] | 75 participants (Actual) | Observational | 2020-01-01 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for trimethyloxamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Metabolites Linking the Gut Microbiome with Risk for Type 2 Diabetes.
Topics: Amino Acids, Branched-Chain; Animals; Bile Acids and Salts; Diabetes Mellitus, Type 2; Diet Therapy; | 2020 |
Roles of Gut Microbial Metabolites in Diabetic Kidney Disease.
Topics: Animals; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Fatty Acids, Volatile; Gastrointestinal | 2021 |
Gut microbe-generated metabolite trimethylamine N-oxide and the risk of diabetes: A systematic review and dose-response meta-analysis.
Topics: Diabetes Mellitus, Type 2; Gastrointestinal Microbiome; Humans; Methylamines; Risk Factors | 2019 |
4 trials available for trimethyloxamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Trimethylamine N-oxide and incident atherosclerotic events in high-risk individuals with diabetes: an ACCORD trial post hoc analysis.
Topics: Aged; Antihypertensive Agents; Atherosclerosis; Case-Control Studies; Diabetes Mellitus, Type 2; Dia | 2019 |
Metabolites and diabetes remission after weight loss.
Topics: Amino Acids, Branched-Chain; Bariatric Surgery; Betaine; Biomarkers; Choline; Diabetes Mellitus, Typ | 2021 |
Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
Topics: Adipose Tissue, White; Adiposity; Adult; Body Weight; Caloric Restriction; Carnitine; Choline; Diabe | 2018 |
Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
Topics: Adipose Tissue, White; Adiposity; Adult; Body Weight; Caloric Restriction; Carnitine; Choline; Diabe | 2018 |
Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
Topics: Adipose Tissue, White; Adiposity; Adult; Body Weight; Caloric Restriction; Carnitine; Choline; Diabe | 2018 |
Changes in Gut Microbiota-Related Metabolites and Long-term Successful Weight Loss in Response to Weight-Loss Diets: The POUNDS Lost Trial.
Topics: Adipose Tissue, White; Adiposity; Adult; Body Weight; Caloric Restriction; Carnitine; Choline; Diabe | 2018 |
Circulating Gut Microbiota Metabolite Trimethylamine N-Oxide (TMAO) and Changes in Bone Density in Response to Weight Loss Diets: The POUNDS Lost Trial.
Topics: Absorptiometry, Photon; Adult; Bone Density; Carnitine; Choline; Diabetes Mellitus, Type 2; Diet, Re | 2019 |
27 other studies available for trimethyloxamine and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Gut Metabolite Trimethylamine N-Oxide Protects INS-1 β-Cell and Rat Islet Function under Diabetic Glucolipotoxic Conditions.
Topics: Animals; Cell Proliferation; Cell Survival; Cells, Cultured; Diabetes Mellitus, Type 2; Endoplasmic | 2021 |
Serum Trimethylamine N-oxide and the Diversity of the Intestinal Microbial Flora in Type 2 Diabetes Complicated by Diabetic Kidney Disease.
Topics: Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Humans; Male; Methylamines; Peptides; Sco | 2022 |
Association between Plasma Trimethylamine N-Oxide Levels and Type 2 Diabetes: A Case Control Study.
Topics: Animals; Case-Control Studies; Chromatography, Liquid; Diabetes Mellitus, Type 2; Humans; Longitudin | 2022 |
Trimethylamine N-oxide facilitates the progression of atrial fibrillation in rats with type 2 diabetes by aggravating cardiac inflammation and connexin remodeling.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Connexins; Diabetes Mellitus, Experimental; Diabete | 2022 |
NMR-Based Metabolomic Analysis for the Effects of Trimethylamine N-Oxide Treatment on C2C12 Myoblasts under Oxidative Stress.
Topics: Alanine; Catalase; Diabetes Mellitus, Type 2; Glycine; Histidine; Humans; Hydrogen Peroxide; Isoleuc | 2022 |
Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spectrometry method.
Topics: Chromatography, Liquid; Diabetes Mellitus, Type 2; Glutamine; Humans; Isotopes; Methylamines; Myocar | 2022 |
Beneficial Effects of Essential Oils from the Mediterranean Diet on Gut Microbiota and Their Metabolites in Ischemic Heart Disease and Type-2 Diabetes Mellitus.
Topics: Animals; Carnitine; Diabetes Mellitus, Type 2; Diet, Mediterranean; Emulsions; Fatty Acids, Volatile | 2022 |
Alterations in trimethylamine-N-oxide in response to Empagliflozin therapy: a secondary analysis of the EMMY trial.
Topics: Aged; Diabetes Mellitus, Type 2; Female; Humans; Male; Middle Aged; Myocardial Infarction; Oxides; S | 2023 |
Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients With Type 2 Diabetes.
Topics: Aged; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Male; Methylamines; Middle | 2020 |
TMAO: Trimethylamine-N-Oxide or Time to Minimize Intake of Animal Products?
Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Methylamines; Oxides; Plasma | 2020 |
Trimethylamine N-oxide levels are associated with NASH in obese subjects with type 2 diabetes.
Topics: Adult; Betaine; Bile Acids and Salts; Biomarkers; Biopsy; Choline; Diabetes Mellitus, Type 2; Female | 2021 |
Assessing the role of osmolytes on the conformational harmony of islet amyloid polypeptide.
Topics: Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Methylamines; Protein Aggregates; Prot | 2020 |
Elevated plasma trimethylamine-N-oxide levels are associated with diabetic retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Case-Control Studies; China; Cross-Sectional Studies; Di | 2021 |
Pre-diagnostic biomarkers of type 2 diabetes identified in the UAE's obese national population using targeted metabolomics.
Topics: 3-Hydroxybutyric Acid; Adult; Alanine; Amino Acids, Branched-Chain; Biomarkers; Chromatography, Liqu | 2020 |
Associations between physical activity and trimethylamine
Topics: Adult; Diabetes Mellitus, Type 2; Exercise; Female; Humans; Male; Methylamines; Sedentary Behavior | 2020 |
Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria.
Topics: Aged; Albuminuria; Biomarkers; Cardiovascular Diseases; Cohort Studies; Denmark; Diabetes Mellitus, | 2021 |
Metformin alleviates choline diet-induced TMAO elevation in C57BL/6J mice by influencing gut-microbiota composition and functionality.
Topics: Akkermansia; Animals; Atherosclerosis; Bifidobacterium; Choline; Diabetes Mellitus, Type 2; Diet; Dy | 2021 |
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation.
Topics: Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure L | 2017 |
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort.
Topics: Aged; Amino Acids; Bacteria; Blood Glucose; Body Mass Index; Cohort Studies; Diabetes Mellitus, Type | 2017 |
The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.
Topics: Adipocytes, Beige; Animals; Diabetes Mellitus, Type 2; Female; Gene Expression; Humans; Male; Methyl | 2017 |
Relationship between gut microbiota and type 2 diabetic erectile dysfunction in Sprague-Dawley rats.
Topics: Animals; Biodiversity; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Erectile Dysfunction; | 2017 |
Plasma trimethylamine-N-oxide and related metabolites are associated with type 2 diabetes risk in the Prevención con Dieta Mediterránea (PREDIMED) trial.
Topics: Aged; Case-Control Studies; Cohort Studies; Diabetes Mellitus, Type 2; Diet, Mediterranean; Female; | 2018 |
The Association between Plasma Levels of Trimethylamine N-Oxide and the Risk of Coronary Heart Disease in Chinese Patients with or without Type 2 Diabetes Mellitus.
Topics: Aged; China; Coronary Disease; Creatine Kinase, MB Form; Diabetes Mellitus, Type 2; Female; Humans; | 2018 |
Cosolvent effects on the fibrillation reaction of human IAPP.
Topics: Amyloid; Betaine; Diabetes Mellitus, Type 2; Humans; Islet Amyloid Polypeptide; Methylamines; Protei | 2013 |
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study.
Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Betaine; Biomarkers; Cardiovascular Diseases; Case | 2014 |
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery.
Topics: Adult; Atherosclerosis; Bariatric Surgery; Betaine; Body Mass Index; Cardiovascular Diseases; Carnit | 2016 |
Increased Trimethylamine N-Oxide Portends High Mortality Risk Independent of Glycemic Control in Patients with Type 2 Diabetes Mellitus.
Topics: Aged; Betaine; Blood Glucose; Choline; Cohort Studies; Diabetes Mellitus, Type 2; Female; Humans; Ma | 2017 |