Page last updated: 2024-10-20

trimethyloxamine and Cognitive Decline

trimethyloxamine has been researched along with Cognitive Decline in 14 studies

trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.

Research Excerpts

ExcerptRelevanceReference
"Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment."9.41Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021)
"Patients with higher choline and betaine levels had lower risk of cognitive impairment after ischemic stroke, supporting promising prognostic roles of choline pathway nutrients for poststroke cognitive impairment."5.41Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke. ( Bu, X; Che, B; Ju, Z; Lu, Z; Qian, S; Wang, A; Xu, T; Zhang, J; Zhang, Y; Zheng, X; Zhong, C, 2021)
"There is increasing evidence for the association of trimethylamine-N-oxide (TMAO) with cognitive impairment after minor stroke or transient ischemic attack (TIA)."4.31Association between plasma trimethylamine-N-oxide and cognitive impairment in patients with transient ischemic attack. ( Bao, Y; Huang, D; Jiang, L; Qv, S; Wang, J; Wang, L; Xu, G; Yang, J; Zhan, X, 2023)
"We examined prospective associations of TMAO, γ-butyrobetaine, crotonobetaine, carnitine, choline, and betaine with risk of cognitive impairment and dementia among older adults aged 65 years and older in the Cardiovascular Health Study (CHS)."4.12Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study. ( de Oliveira Otto, MC; Fretts, A; Hazen, SL; Lai, HTM; Lee, Y; Lemaitre, RN; Li, XS; Lopez, O; Mozaffarian, D; Nemet, I; Newman, AB; Siscovick, DS; Tang, WHW; Wang, M; Wang, Z, 2022)

Research

Studies (14)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (28.57)24.3611
2020's10 (71.43)2.80

Authors

AuthorsStudies
de Oliveira Otto, MC1
Li, XS1
Wang, Z1
Siscovick, DS1
Newman, AB1
Lai, HTM1
Nemet, I1
Lee, Y1
Wang, M1
Fretts, A1
Lemaitre, RN1
Tang, WHW1
Lopez, O1
Hazen, SL1
Mozaffarian, D1
Buawangpong, N1
Pinyopornpanish, K1
Phrommintikul, A1
Chindapan, N1
Devahastin, S1
Chattipakorn, N1
Chattipakorn, SC1
Deng, Y3
Zou, J3
Hong, Y3
Peng, Q3
Fu, X3
Duan, R3
Chen, J3
Chen, X3
Zhang, Y4
Wang, G3
Li, R3
Liu, R3
Yu, Z3
Zhang, Z3
Wan, Z3
Tu, R1
Xia, J1
Wang, L1
Zhan, X1
Jiang, L2
Xu, G1
Bao, Y1
Wang, J1
Qv, S1
Yang, J1
Huang, D1
Liu, J2
Zhou, S1
Wang, Y1
Sun, S1
Sun, Y1
Xu, P1
Xu, X1
Zhu, B1
Wu, H1
Zhu, C1
Li, G1
Lv, Z1
Li, J1
Wang, X1
Kang, J1
Zhan, C1
Zhao, L1
Zhang, C1
Cao, G1
Dong, X1
Li, D3
Tan, AH1
Chong, CW1
Lim, SY1
Yap, IKS1
Teh, CSJ1
Loke, MF1
Song, SL1
Tan, JY1
Ang, BH1
Tan, YQ1
Kho, MT1
Bowman, J1
Mahadeva, S1
Yong, HS1
Lang, AE1
Zhong, C1
Lu, Z1
Che, B1
Qian, S1
Zheng, X1
Wang, A1
Bu, X1
Zhang, J1
Ju, Z1
Xu, T1
Ke, Y1
Zhan, R1
Liu, C1
Zhao, M1
Zeng, A1
Shi, X1
Ji, L1
Cheng, S1
Pan, B1
Zheng, L1
Hong, H1
Vogt, NM1
Romano, KA1
Darst, BF1
Engelman, CD1
Johnson, SC1
Carlsson, CM1
Asthana, S1
Blennow, K1
Zetterberg, H1
Bendlin, BB1
Rey, FE1
Meng, F1
Li, N1
Song, B1
Li, L1

Reviews

1 review available for trimethyloxamine and Cognitive Decline

ArticleYear
Stroke and Vascular Cognitive Impairment: The Role of Intestinal Microbiota Metabolite TMAO.
    CNS & neurological disorders drug targets, 2024, Volume: 23, Issue:1

    Topics: Choline; Cognitive Dysfunction; Gastrointestinal Microbiome; Humans; Inflammation; Stroke; Thrombosi

2024

Trials

1 trial available for trimethyloxamine and Cognitive Decline

ArticleYear
Choline Pathway Nutrients and Metabolites and Cognitive Impairment After Acute Ischemic Stroke.
    Stroke, 2021, Volume: 52, Issue:3

    Topics: Aged; Antihypertensive Agents; Brain Ischemia; China; Choline; Cognition; Cognition Disorders; Cogni

2021

Other Studies

12 other studies available for trimethyloxamine and Cognitive Decline

ArticleYear
Longitudinal Associations of Plasma TMAO and Related Metabolites with Cognitive Impairment and Dementia in Older Adults: The Cardiovascular Health Study.
    Journal of Alzheimer's disease : JAD, 2022, Volume: 89, Issue:4

    Topics: Animals; Betaine; Carnitine; Choline; Cognitive Dysfunction; Dementia; Medicare; Methylamines; Unite

2022
Increased plasma trimethylamine-
    Food & function, 2022, Oct-03, Volume: 13, Issue:19

    Topics: Aged; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cognitive Dysfunction; Heart Disease Risk

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Higher Circulating Trimethylamine N-Oxide Aggravates Cognitive Impairment Probably via Downregulating Hippocampal SIRT1 in Vascular Dementia Rats.
    Cells, 2022, 11-17, Volume: 11, Issue:22

    Topics: Animals; Cognitive Dysfunction; Dementia, Vascular; Hippocampus; Inflammation; Rats; Sirtuin 1; Vasc

2022
Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise.
    Neurochemistry international, 2023, Volume: 162

    Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betaine; Brain-Derived

2023
Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise.
    Neurochemistry international, 2023, Volume: 162

    Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betaine; Brain-Derived

2023
Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise.
    Neurochemistry international, 2023, Volume: 162

    Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betaine; Brain-Derived

2023
Trimethylamine N-oxide aggravated cognitive impairment from APP/PS1 mice and protective roles of voluntary exercise.
    Neurochemistry international, 2023, Volume: 162

    Topics: Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Betaine; Brain-Derived

2023
Association between plasma trimethylamine-N-oxide and cognitive impairment in patients with transient ischemic attack.
    Neurological research, 2023, Volume: 45, Issue:7

    Topics: Aged; Cognitive Dysfunction; Humans; Ischemic Attack, Transient; Male; Oxides; Retrospective Studies

2023
ZeXieYin Formula alleviates TMAO-induced cognitive impairment by restoring synaptic plasticity damage.
    Journal of ethnopharmacology, 2023, Oct-05, Volume: 314

    Topics: Animals; Cognitive Dysfunction; Learning; Mice; Neuronal Plasticity; TOR Serine-Threonine Kinases

2023
Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study.
    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020, Volume: 41, Issue:1

    Topics: Aged; Aged, 80 and over; Biomarkers; Brain Ischemia; Cognitive Dysfunction; Female; Follow-Up Studie

2020
Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A.
    Neurochemical research, 2019, Volume: 44, Issue:11

    Topics: Animals; Cognitive Dysfunction; Down-Regulation; Fear; Hippocampus; Inflammation; Interleukin-1beta;

2019
Gut Microbial Ecosystem in Parkinson Disease: New Clinicobiological Insights from Multi-Omics.
    Annals of neurology, 2021, Volume: 89, Issue:3

    Topics: Aged; Ceramides; Chromatography, Liquid; Cognitive Dysfunction; Constipation; Fatty Acids, Volatile;

2021
Trimethylamine-N-oxide promotes brain aging and cognitive impairment in mice.
    Aging cell, 2018, Volume: 17, Issue:4

    Topics: Adolescent; Adult; Aged; Animals; Brain; Cellular Senescence; Cognitive Dysfunction; Humans; Male; M

2018
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.
    Alzheimer's research & therapy, 2018, 12-22, Volume: 10, Issue:1

    Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Female; Gastroint

2018
The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats.
    Behavioural brain research, 2019, 08-05, Volume: 368

    Topics: Age Factors; Animals; Brain; Cognitive Dysfunction; Disease Models, Animal; Gastrointestinal Microbi

2019