Page last updated: 2024-10-20

trimethyloxamine and Cardiovascular Diseases

trimethyloxamine has been researched along with Cardiovascular Diseases in 174 studies

trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.

Cardiovascular Diseases: Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Research Excerpts

ExcerptRelevanceReference
" Trimethylamine N-oxide (TMAO) is reportedly associated with deteriorating metabolic profiles and cardiovascular diseases."8.31Association of Circulating Trimethylamine-N Oxide With Malnutrition and the Risk of Coronary Artery Disease in Patients With Maintenance Hemodialysis. ( Huang, Y; Liu, J; Peng, L; Tang, C; Wang, H; Wei, X; Yuan, X, 2023)
"Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver."6.72Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases. ( He, S; Jiang, H; Jiang, W; Zhuo, C, 2021)
" Trimethylamine N-oxide (TMAO) is produced from the metabolism of dietary choline and L-carnitine by intestinal microbiota, and many studies have shown that this important product inhibits cholesterol metabolism, induces platelet aggregation and thrombosis, and promotes atherosclerosis."5.41The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases. ( Cai, XC; Han, HX; He, M; Kang, XX; Liu, X; Lv, EH; Tian, JQ; Wang, YT; Wen, PB; Xiao, L; Zhang, MY; Zhen, J; Zhou, Z, 2023)
" More specifically, we review data on the following: (i) tryptophan metabolites and chronic kidney disease onset, illustrating the interpretation of metabolite data in the context of established biochemical pathways; (ii) trimethylamine-N-oxide and cardiovascular disease in chronic kidney disease, illustrating the integration of exogenous and endogenous inputs to the blood metabolome; and (iii) renal mitochondrial function in diabetic kidney disease and acute kidney injury, illustrating the potential for rapid translation of metabolite data for diagnostic or therapeutic aims."4.95An overview of renal metabolomics. ( Kalim, S; Rhee, EP, 2017)
" Trimethylamine N-oxide (TMAO) is reportedly associated with deteriorating metabolic profiles and cardiovascular diseases."4.31Association of Circulating Trimethylamine-N Oxide With Malnutrition and the Risk of Coronary Artery Disease in Patients With Maintenance Hemodialysis. ( Huang, Y; Liu, J; Peng, L; Tang, C; Wang, H; Wei, X; Yuan, X, 2023)
"Trimethylamine-N-oxide (TMAO) has been suggested as a marker and mediator of cardiovascular diseases."3.91TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology. ( Bielak-Zmijewska, A; Filipiak, K; Gasecka, A; Hering, D; Hołyst, R; Jaworska, K; Kapłon-Cieślicka, A; Konwerski, M; Mosieniak, G; Pilz, M; Sikora, E; Ufnal, M, 2019)
" Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo."3.88Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018)
"There is a dose-response relationship between TMAO levels and NCDs progression."3.01Trimethylamine N-Oxide as a Potential Risk Factor for Non-communicable Diseases: A Systematic Review. ( Ejtahed, HS; Hasani-Ranjbar, S; Hoseini-Tavassol, Z; Larijani, B, 2023)
" We aimed to assess the correlation between circulating TMAO concentration and the risk of all-cause and cardiovascular death in CKD patients of different dialysis statuses and different races by dose-response analyses, and the underlying mechanisms were also explored by analyzing the correlations of TMAO with glomerular filtration rate (GFR) and inflammation."3.01Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and dose-response meta-analysis. ( Guo, J; Li, Y; Liu, W; Liu, Y; Lu, H; Zhang, M; Zheng, H, 2023)
"Atherosclerotic cardiovascular diseases are preferential targets of healthy diet and preventive medicine partially through strategies to improve lipid profile and counteract oxidative metabolites."2.90Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial. ( Bocchino, B; Buonomo, G; Caruso, D; Ciampaglia, R; D'Avino, M; Maisto, M; Novellino, E; Schisano, C; Tenore, GC, 2019)
"Chronic obstructive pulmonary disease (COPD) is a prevalent disease worldwide with a high associated risk for cardiovascular disease and death due to an infectious cause."2.87Gut, microbiota-dependent trimethylamine-N-oxide is associated with long-term all-cause mortality in patients with exacerbated chronic obstructive pulmonary disease. ( Bernasconi, L; Christ-Crain, M; Henzen, C; Hoess, C; Huber, A; Mueller, B; Nickler, M; Ottiger, M; Schuetz, P; Steuer, C; Thomann, R; Zimmerli, W, 2018)
"The changes of intestinal bacteria in ESRD patients have contributed to the accumulation of gut-derived uremic toxins such as TMAO, indoxyl sulfate and indole-3-acetic acid."2.82[Gut-derived uremic toxin trimethylamine-N-oxide in cardiovascular disease under end-stage renal disease: an injury mechanism and therapeutic target]. ( Ren, Y; Wang, Z; Xue, J, 2022)
"The aim of this systematic review and meta-analysis was to summarize evidence of the relationship between circulating TMAO levels and risk of hypertension and increased serum lipids in a dose-response and 2-class meta-analysis of discrete and continuous variables."2.72Gut microbiota-associated trimethylamine N-oxide and increased cardiometabolic risk in adults: a systematic review and dose-response meta-analysis. ( Abbasalizad Farhangi, M; Vajdi, M, 2021)
"Trimethylamine (TMA) is a gut microbiota-derived metabolite which comes from diets rich of choline, betaine or L-carnitine and could be further converted to Trimethylamine-N-oxide (TMAO) in the liver."2.72Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases. ( He, S; Jiang, H; Jiang, W; Zhuo, C, 2021)
"Phenylacetylglutamine, for example, was recently shown to promote adverse cardiovascular phenotypes in the host via interaction with multiple ARs (adrenergic receptors)-a class of key receptors that regulate cardiovascular homeostasis."2.66Gut Microbiota and Cardiovascular Disease. ( Hazen, SL; Weeks, TL; Witkowski, M, 2020)
"Choline is a water-soluble nutrient essential for human life."2.66The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases. ( Allison, J; Arboleya, S; Arias, JL; Arias, N; Gueimonde, M; Higarza, SG; Kaliszewska, A, 2020)
"0001) according to the dose-response meta-analysis."2.66The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis. ( Fan, H; Ge, X; Liu, G; Xi, X; Xu, Z; Yu, P; Zheng, L; Zhou, X; Zhuang, R, 2020)
"Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier, which in turn increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of CVD."2.58The gut microbiota as a novel regulator of cardiovascular function and disease. ( Battson, ML; Gentile, CL; Lee, DM; Weir, TL, 2018)
" Dose-response meta-analysis revealed that the relative risk (RR) for all-cause mortality increased by 7."2.55Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis. ( Esposito, G; Franzone, A; Gargiulo, G; Giugliano, G; Perrino, C; Sannino, A; Schiattarella, GG; Toscano, E; Trimarco, B, 2017)
"This case-cohort study included Chronic Renal Insufficiency Cohort participants with baseline diabetes, estimated glomerular filtration rate <60 mL/min/1."1.91Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. ( Anderson, AH; Bhat, Z; Brown, J; Brunengraber, H; Charleston, J; Chen, J; Feldman, HI; He, J; Hostetter, TH; Hsu, CY; Ix, JH; Kimmel, PL; Mehta, R; Rao, P; Sapa, H; Schelling, JR; Schrauben, SJ; Seegmiller, JC; Shafi, T; Shlipak, MG; Townsend, R; Vasan, RS; Xie, D; Zhang, X, 2023)
"Vascular dysfunction: develops progressively with ageing; increases the risk of cardiovascular diseases (CVD); and is characterized by endothelial dysfunction and arterial stiffening, which are primarily mediated by superoxide-driven oxidative stress and consequently reduced nitric oxide (NO) bioavailability and arterial structural changes."1.72Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. ( Brunt, VE; Casso, AG; Clayton, ZS; Davy, KP; Gioscia-Ryan, RA; Greenberg, NT; Hutton, DA; Neilson, AP; Seals, DR; VanDongen, NS; Ziemba, BP, 2022)
"Atherosclerosis is a hallmark of cardiovascular disease, and lifestyle strongly impacts its onset and progression."1.72TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. ( Blanco, R; Daimiel, L; Dávalos, A; Díez-Ricote, L; Micó, V; Ordovás, JM; Ruiz-Valderrey, P; Tomé-Carneiro, J, 2022)
"Choline was associated with higher systolic blood pressure, TGs, lipopolysaccharide-binding protein, and lower HDL cholesterol (P ranging from <0."1.56Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study. ( Cheng, I; Franke, AA; Fu, BC; Hullar, MAJ; Lampe, JW; Le Marchand, L; Lim, U; Madeleine, MM; Monroe, KR; Randolph, TW; Shepherd, JA; Wilkens, LR, 2020)
" Dose-response analysis revealed a linear association between the TMAO concentration and the OR for frailty."1.56Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease. ( Cui, LL; Guo, D; He, W; Liu, JP; Luo, Y; Sun, N; Wang, H; Yang, JF; Yao, SM; Zheng, PP, 2020)
"Furthermore, cardiovascular diseases are associated with disturbances in water-electrolyte balance which produce changes in plasma osmolarity."1.51Is increased plasma TMAO a compensatory response to hydrostatic and osmotic stress in cardiovascular diseases? ( Nowiński, A; Ufnal, M, 2019)
"L-carnitine has been advertised as a fat-lowering and performance-enhancing supplement, although scientific evidence for its effectiveness is lacking."1.46The influence of a chronic L-carnitine administration on the plasma metabolome of male Fischer 344 rats. ( Egert, B; Empl, MT; Frommherz, L; Krüger, R; Kulling, SE; Steinberg, P; Weinert, CH, 2017)
"Betaine is a major osmolyte, also important in methyl group metabolism."1.40Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study. ( Atkinson, W; Bellamy, D; Chambers, ST; Elmslie, JL; Frampton, CM; George, PM; Ho, M; Lever, M; McEntyre, CJ; Molyneux, SL; Richards, AM; Slow, S; Troughton, RW; Young, JM, 2014)

Research

Studies (174)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's85 (48.85)24.3611
2020's89 (51.15)2.80

Authors

AuthorsStudies
Annunziata, G2
Ciampaglia, R3
Capò, X1
Guerra, F1
Sureda, A1
Tenore, GC3
Novellino, E3
Xie, G1
Yan, A1
Lin, P1
Wang, Y3
Guo, L1
Ringel, C1
Dittrich, J1
Gaudl, A1
Schellong, P1
Beuchel, CF1
Baber, R1
Beutner, F1
Teren, A1
Engel, C1
Wirkner, K1
Thiele, H1
Büttner, P1
Löffler, M1
Scholz, M1
Thiery, J1
Ceglarek, U1
Díez-Ricote, L2
Ruiz-Valderrey, P2
Micó, V2
Blanco-Rojo, R1
Tomé-Carneiro, J2
Dávalos, A2
Ordovás, JM2
Daimiel, L2
Chang, D1
Xu, X2
Yang, Z1
Ma, T1
Nie, J1
Dong, J2
Kang, JW1
Zivkovic, AM1
Chen, G1
He, L1
Dou, X1
Liu, T1
Nandi, S1
Pyne, A1
Layek, S1
Arora, C1
Sarkar, N1
Buffa, JA3
Romano, KA2
Copeland, MF1
Cody, DB1
Zhu, W2
Galvez, R1
Fu, X4
Ward, K1
Ferrell, M1
Dai, HJ1
Skye, S1
Hu, P1
Li, L3
Parlov, M1
McMillan, A1
Wei, X2
Nemet, I3
Koeth, RA3
Li, XS7
Wang, Z16
Sangwan, N1
Hajjar, AM1
Dwidar, M1
Weeks, TL2
Bergeron, N2
Krauss, RM2
Tang, WHW7
Rey, FE3
DiDonato, JA6
Gogonea, V1
Gerberick, GF1
Garcia-Garcia, JC1
Hazen, SL19
Amrein, M1
Walter, J1
Zimmermann, T1
Strebel, I1
Honegger, U1
Leu, K1
Schäfer, I1
Twerenbold, R1
Puelacher, C1
Glarner, N1
Nestelberger, T1
Koechlin, L1
Ceresa, B1
Haaf, P1
Bakula, A1
Zellweger, M1
Mueller, C1
Li, D1
Lu, Y5
Yuan, S1
Cai, X1
He, Y3
Chen, J3
Wu, Q1
He, D1
Fang, A1
Bo, Y1
Song, P1
Bogaert, D1
Tsilidis, K1
Larsson, SC1
Yu, H1
Zhu, H1
Theodoratou, E1
Zhu, Y5
Li, X3
Sapa, H2
Gutiérrez, OM1
Shlipak, MG2
Katz, R1
Ix, JH2
Sarnak, MJ1
Cushman, M1
Rhee, EP2
Kimmel, PL2
Vasan, RS2
Schrauben, SJ2
Feldman, HI2
Seegmiller, JC2
Brunengraber, H2
Hostetter, TH3
Schelling, JR2
Konieczny, RA2
Kuliczkowski, W3
Bean, LD1
Wing, JJ1
Harris, RE1
Smart, SM1
Raman, SV1
Milks, MW1
Cantero, MA1
Guedes, MRA1
Fernandes, R1
Lollo, PCB1
Fretts, AM1
Jensen, P1
Budoff, M3
Sitlani, CM1
Wang, M3
de Oliveira Otto, MC3
Lee, Y2
Psaty, BM3
Siscovick, DS3
Sotoodehnia, N3
Lai, H1
Lemaitre, RN3
Mozaffarian, D3
Żurawska-Płaksej, E2
Kaaz, K2
Czapor-Irzabek, H2
Bombała, W2
Mysiak, A2
Li, DY2
Chaikijurajai, T1
Lai, HTM1
Fretts, A2
McKnight, B1
Konieczny, R1
Hsu, BG1
Wang, CH1
Lin, YL1
Lai, YH1
Tsai, JP1
Ren, Y1
Xue, J2
Buawangpong, N1
Pinyopornpanish, K1
Phrommintikul, A2
Chindapan, N1
Devahastin, S1
Chattipakorn, N1
Chattipakorn, SC1
Casso, AG1
VanDongen, NS1
Gioscia-Ryan, RA1
Clayton, ZS1
Greenberg, NT1
Ziemba, BP1
Hutton, DA1
Neilson, AP2
Davy, KP2
Seals, DR1
Brunt, VE1
Zhu, B1
Ren, H1
Xie, F1
An, Y1
Tan, Y1
Huang, Y2
Zhang, H2
Fan, X1
Wang, J1
Yin, Y1
Zhang, Y1
Shi, K1
Yu, F1
Blanco, R1
Hoseini-Tavassol, Z1
Ejtahed, HS1
Larijani, B1
Hasani-Ranjbar, S1
Saaoud, F4
Liu, L3
Xu, K3
Cueto, R3
Shao, Y3
Sun, Y5
Snyder, NW3
Wu, S3
Yang, L3
Zhou, Y3
Williams, DL3
Li, C3
Martinez, L3
Vazquez-Padron, RI3
Zhao, H3
Jiang, X3
Wang, H6
Yang, X4
Cao, H3
Hu, G3
Zhang, Q3
Zheng, L5
Yuan, X1
Liu, J2
Tang, C1
Peng, L1
Canyelles, M1
Borràs, C1
Rotllan, N1
Tondo, M1
Escolà-Gil, JC1
Blanco-Vaca, F1
Tacconi, E1
Palma, G1
De Biase, D1
Luciano, A1
Barbieri, M1
de Nigris, F1
Bruzzese, F1
Zhen, J1
Zhou, Z1
He, M2
Han, HX1
Lv, EH1
Wen, PB1
Liu, X2
Wang, YT1
Cai, XC1
Tian, JQ1
Zhang, MY1
Xiao, L1
Kang, XX1
Çelikkol, A1
Mercan, R1
Güzel, S1
Yılmaz, A1
Mu, HN1
Zhao, XH1
Zhang, RR1
Li, ZY1
Yang, RY1
Wang, SM1
Li, HX1
Chen, WX1
Naghipour, S2
Fisher, JJ1
Perkins, AV1
Peart, JN2
Headrick, JP2
Toit, EFD1
Lei, D1
Yu, W1
Liu, Y4
Jiang, Y1
Lv, J1
Li, Y4
Xie, D1
Zhang, X3
Anderson, AH1
Hsu, CY1
Shafi, T2
Mehta, R1
Bhat, Z1
Brown, J1
Charleston, J1
He, J1
Rao, P1
Townsend, R1
Lu, H1
Guo, J1
Zhang, M1
Zheng, H1
Liu, W1
Yang, Y1
Karampoor, S1
Mirzaei, R1
Borozdkin, L1
Zhu, P2
Hemmati, M1
Kashanipoor, S1
Mazaheri, P1
Alibabaei, F1
Babaeizad, A1
Asli, S1
Mohammadi, S1
Gorgin, AH1
Ghods, K1
Yousefi, B1
Eslami, M1
Belli, M1
Barone, L1
Longo, S1
Prandi, FR1
Lecis, D1
Mollace, R1
Margonato, D1
Muscoli, S1
Sergi, D1
Federici, M1
Barillà, F1
Lee, H1
An, JP1
Chan, MM1
Fong, D1
Jaworska, K2
Konop, M1
Hutsch, T1
Perlejewski, K1
Radkowski, M1
Grochowska, M1
Bielak-Zmijewska, A2
Mosieniak, G2
Sikora, E2
Ufnal, M5
Hering, D1
Pilz, M1
Konwerski, M1
Gasecka, A1
Kapłon-Cieślicka, A1
Filipiak, K1
Hołyst, R1
Mitchell, SM1
Milan, AM1
Mitchell, CJ1
Gillies, NA1
D'Souza, RF1
Zeng, N1
Ramzan, F1
Sharma, P1
Knowles, SO1
Roy, NC1
Sjödin, A1
Wagner, KH1
Zeisel, SH1
Cameron-Smith, D1
Eyupoglu, ND1
Caliskan Guzelce, E1
Acikgoz, A1
Uyanik, E1
Bjørndal, B1
Berge, RK4
Svardal, A3
Yildiz, BO1
Kasahara, K1
Moludi, J1
Maleki, V1
Jafari-Vayghyan, H1
Vaghef-Mehrabany, E1
Alizadeh, M1
Dai, Q1
Berger, M1
Kleber, ME1
Delgado, GE1
März, W1
Andreas, M1
Hellstern, P1
Marx, N1
Schuett, KA1
Montrucchio, C1
De Nicolò, A1
D'Ettorre, G1
D'Ascenzo, F1
Lazzaro, A1
Tettoni, M1
D'Avolio, A1
Bonora, S1
Celani, L1
Di Perri, G1
Calcagno, A1
Fu, BC1
Hullar, MAJ1
Randolph, TW1
Franke, AA1
Monroe, KR1
Cheng, I1
Wilkens, LR1
Shepherd, JA1
Madeleine, MM1
Le Marchand, L1
Lim, U1
Lampe, JW1
Yue, SJ1
Wang, WX1
Tao, HJ1
Bai, X1
Huang, YX1
Zhang, S1
Shen, X1
Liu, JP2
Tang, YP1
Fadhlaoui, K1
Arnal, ME1
Martineau, M1
Camponova, P1
Ollivier, B1
O'Toole, PW1
Brugère, JF1
Croyal, M1
Saulnier, PJ1
Aguesse, A1
Gand, E1
Ragot, S1
Roussel, R1
Halimi, JM1
Ducrocq, G1
Cariou, B1
Montaigne, D1
Wargny, M1
Krempf, M1
Hadjadj, S1
Meyer, KA1
Papandreou, C1
Moré, M1
Bellamine, A1
Dannenberg, L1
Zikeli, D1
Benkhoff, M1
Ahlbrecht, S1
Kelm, M1
Levkau, B1
Polzin, A1
Özcan-Ekşi, EE1
Ekşi, MŞ1
Turgut, VU1
Canbolat, Ç1
Pamir, MN1
Nocentini, A1
Del Prete, S1
Mastrolorenzo, MD1
Donald, WA1
Capasso, C1
Supuran, CT1
Zheng, Y4
Tang, Z1
You, L1
Wu, Y5
Bin Waleed, K1
Liu, Q1
Zeng, F1
Tu, H1
Wei, Y1
Xu, S1
Zhang, Z2
Rongfeng, Y1
Fan, A1
Altaf, A1
Chang, J1
Wang, L1
Winther, SA2
Rossing, P2
Shui, X1
Liang, Z1
Huang, Z1
Qi, Y1
Chen, C1
Luo, H1
Lei, W1
Cox, AJ1
Du Toit, EF1
Cho, CE1
Aardema, NDJ1
Bunnell, ML1
Larson, DP1
Aguilar, SS1
Bergeson, JR1
Malysheva, OV2
Caudill, MA2
Lefevre, M1
Witkowski, M1
Arias, N1
Arboleya, S1
Allison, J1
Kaliszewska, A1
Higarza, SG1
Gueimonde, M1
Arias, JL1
Guasti, L1
Galliazzo, S1
Molaro, M1
Visconti, E1
Pennella, B1
Gaudio, GV1
Lupi, A1
Grandi, AM1
Squizzato, A1
Crimarco, A1
Springfield, S1
Petlura, C1
Streaty, T1
Cunanan, K1
Lee, J1
Fielding-Singh, P1
Carter, MM1
Topf, MA1
Wastyk, HC1
Sonnenburg, ED1
Sonnenburg, JL1
Gardner, CD1
Ravid, JD1
Chitalia, VC1
Zhang, P1
Zou, JZ1
Tan, X1
Xiang, FF1
Shen, B1
Hu, JC1
Wang, JL1
Wang, YQ1
Yu, JB1
Nie, YX1
Chen, XH1
Yu, JW1
Lv, WL1
Xie, YQ1
Cao, XS1
Ding, XQ1
He, W1
Luo, Y1
Sun, N1
Guo, D1
Cui, LL1
Zheng, PP1
Yao, SM1
Yang, JF1
Zhou, W1
Cheng, Y1
Nasser, MI1
Zhao, M1
Rajendiran, E1
Ramadass, B1
Ramprasath, V1
Bordoni, L1
Samulak, JJ1
Sawicka, AK1
Pelikant-Malecka, I1
Radulska, A1
Lewicki, L1
Kalinowski, L1
Gabbianelli, R1
Olek, RA1
Ebert, T1
Painer, J1
Bergman, P4
Qureshi, AR2
Giroud, S1
Stalder, G1
Kublickiene, K1
Göritz, F1
Vetter, S1
Bieber, C1
Fröbert, O1
Arnemo, JM1
Zedrosser, A1
Redtenbacher, I1
Shiels, PG1
Johnson, RJ1
Stenvinkel, P4
Abbasalizad Farhangi, M1
Vajdi, M1
Tan, CP1
Xu, YJ1
Duttaroy, AK1
Iglesias-Carres, L1
Hughes, MD1
Steele, CN1
Ponder, MA1
Thomas, MS1
Fernandez, ML2
Øllgaard, JC1
Hansen, TW1
von Scholten, BJ1
Reinhard, H1
Ahluwalia, TS1
Gæde, P1
Parving, HH1
Hazen, S1
Pedersen, O1
Mei, Z1
Chen, GC1
Usyk, M1
Yu, B1
Baeza, YV1
Humphrey, G1
Benitez, RS1
Li, J3
Williams-Nguyen, JS1
Daviglus, ML1
Hou, L1
Cai, J1
Knight, R2
Burk, RD1
Boerwinkle, E1
Kaplan, RC1
Qi, Q1
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Wilkinson, JE1
Franke, A1
Lee, KH1
Chan, A1
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Hu, FB3
Rimm, EB2
Sun, Q1
He, S1
Jiang, H1
Zhuo, C1
Jiang, W1
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Brooks, CR1
Senthong, V2
Kiatchoosakun, S1
Wongvipaporn, C1
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Tatsanavivat, P1
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Bennett, DW1
Connelly, MA1
Otvos, JD1
Jeyarajah, EJ1
Haissman, JM1
Haugaard, AK1
Ostrowski, SR1
Hov, JR2
He, Z1
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Heianza, Y1
Ma, W1
Manson, JE2
Rexrode, KM2
Qi, L2
Krüger, R2
Merz, B1
Rist, MJ1
Ferrario, PG1
Bub, A1
Kulling, SE2
Watzl, B1
Qi, J1
You, T1
Pan, T1
Xiang, L1
Han, Y2
Zhu, L1
Tomlinson, JAP1
Wheeler, DC1
Ottiger, M1
Nickler, M1
Steuer, C1
Bernasconi, L1
Huber, A1
Christ-Crain, M1
Henzen, C1
Hoess, C1
Thomann, R1
Zimmerli, W1
Mueller, B1
Schuetz, P1
Schiattarella, GG2
Sannino, A1
Toscano, E1
Giugliano, G1
Gargiulo, G1
Franzone, A1
Trimarco, B2
Esposito, G1
Perrino, C1
Guasch-Ferré, M1
Ruiz-Canela, M1
Bulló, M1
Toledo, E1
Corella, D1
Gómez-Gracia, E1
Fiol, M1
Estruch, R1
Lapetra, J1
Fitó, M1
Arós, F1
Serra-Majem, L1
Ros, E1
Dennis, C1
Liang, L1
Clish, CB1
Martínez-González, MA1
Salas-Salvadó, J1
Ascher, S1
Reinhardt, C1
Mafra, D2
Borges, NA1
Cardozo, LFMF1
Anjos, JS1
Black, AP1
Moraes, C2
Lindholm, B2
Nowiński, A2
Missimer, A1
DiMarco, DM1
Norris, GH1
Blesso, CN2
Murillo, AG1
Vergara-Jimenez, M1
Lemos, BS1
Medina-Vera, I1
Battson, ML1
Lee, DM1
Weir, TL1
Gentile, CL1
Schmedes, M1
Brejnrod, AD1
Aadland, EK1
Kiilerich, P1
Kristiansen, K1
Jacques, H1
Lavigne, C1
Graff, IE1
Eng, Ø1
Holthe, A1
Mellgren, G1
Young, JF1
Sundekilde, UK1
Liaset, B1
Bertram, HC1
Cajka, T1
Hurd, AG1
Gu, X1
Skye, SM1
Roberts, AB1
Shahen, CJ1
Wagner, MA1
Hartiala, JA1
Kerby, RL1
Obeid, S1
Lüscher, TF1
Allayee, H2
Fiehn, O2
Missailidis, C2
Neogi, U1
Nowak, P1
Rhainds, D1
Brodeur, MR1
Tardif, JC1
Haghikia, A2
Liman, TG1
Bledau, N1
Schmidt, D1
Zimmermann, F1
Kränkel, N1
Widera, C1
Sonnenschein, K1
Weissenborn, K1
Fraccarollo, D1
Heimesaat, MM1
Bauersachs, J1
Bavendiek, U1
Endres, M1
Landmesser, U1
Manor, O1
Zubair, N1
Conomos, MP1
Rohwer, JE1
Krafft, CE1
Lovejoy, JC1
Magis, AT1
Latkovskis, G2
Makarova, E1
Mazule, M1
Bondare, L1
Hartmane, D2
Cirule, H1
Grinberga, S2
Erglis, A2
Liepinsh, E2
Dambrova, M2
Janeiro, MH1
Ramírez, MJ1
Milagro, FI1
Martínez, JA1
Solas, M1
Kanitsoraphan, C1
Rattanawong, P1
Charoensri, S1
Wu, WK1
Chen, CC1
Liu, PY1
Panyod, S1
Liao, BY1
Chen, PC1
Kao, HL1
Kuo, HC1
Kuo, CH1
Chiu, THT1
Chen, RA1
Chuang, HL1
Huang, YT1
Zou, HB1
Hsu, CC1
Chang, TY1
Lin, CL1
Ho, CT1
Yu, HT1
Sheen, LY1
Wu, MS1
Peng, J1
Xiao, X1
Hu, M1
Al-Rubaye, H1
Perfetti, G1
Kaski, JC1
Zheng, J1
Xie, Y1
Li, Z1
Guo, X1
Sun, G1
Sun, Z1
Xing, F1
Caruso, D1
Buonomo, G1
D'Avino, M1
Maisto, M2
Schisano, C2
Bocchino, B1
Narciso, V1
Stubbs, JR1
Stedman, MR1
Liu, S1
Long, J1
Franchetti, Y1
West, RE1
Prokopienko, AJ1
Mahnken, JD1
Chertow, GM2
Nolin, TD1
Jin, M1
Qian, Z1
Yin, J2
Xu, W1
Zhou, X2
Cassambai, S1
Salzano, A1
Yazaki, Y1
Bernieh, D1
Wong, M1
Israr, MZ1
Heaney, LM2
Suzuki, T2
Park, JE1
Miller, M1
Rhyne, J1
Kalagi, NA1
Abbott, KA1
Alburikan, KA1
Alkofide, HA1
Stojanovski, E1
Garg, ML1
Abbasi, J1
Ge, X1
Zhuang, R1
Yu, P1
Xu, Z1
Liu, G1
Xi, X1
Fan, H1
Tang, WH5
Levison, BS3
Britt, EB3
Loscalzo, J1
Stock, J1
Miller, MJ1
Ussher, JR1
Lopaschuk, GD1
Arduini, A1
Brown, JM2
Fan, Y1
Khan, MS1
Bawany, FI1
Khan, A1
Lever, M1
George, PM1
Slow, S1
Bellamy, D1
Young, JM1
Ho, M1
McEntyre, CJ1
Elmslie, JL1
Atkinson, W1
Molyneux, SL1
Troughton, RW1
Frampton, CM1
Richards, AM1
Chambers, ST1
Kaysen, GA1
Johansen, KL1
Dalrymple, LS1
Kornak, J1
Grimes, B1
Dwyer, T1
Chassy, AW1
Fouque, D1
Amaral, AC1
Mente, A1
Chalcraft, K1
Ak, H1
Davis, AD1
Lonn, E1
Miller, R1
Potter, MA1
Yusuf, S1
Anand, SS1
McQueen, MJ1
Jones, DJ1
Mbasu, RJ1
Ng, LL1
Aron-Wisnewsky, J1
Clément, K1
Hällqvist, J1
Barany, P1
Heimbürger, O1
Obeid, R1
Awwad, HM1
Rabagny, Y1
Graeber, S1
Herrmann, W1
Geisel, J1
Nestvold, TK1
Thoresen, H1
Lappegård, KT1
Kim, RB1
Morse, BL1
Djurdjev, O1
Tang, M1
Muirhead, N1
Barrett, B1
Holmes, DT1
Madore, F1
Clase, CM1
Rigatto, C1
Levin, A1
Mondal, JA1
Wang, S1
Xia, GH1
Liao, SX1
Sheng, HF1
Zhou, HW1
Kuka, J1
Strele, I1
Konrade, I1
Pugovics, O1
Fennema, D1
Phillips, IR1
Shephard, EA1
Albert, CM1
Powe, NR1
Meyer, TW1
Hwang, S1
Hai, X1
Melamed, ML1
Banerjee, T1
Coresh, J1
Chhibber-Goel, J1
Singhal, V1
Parakh, N1
Bhargava, B1
Sharma, A1
Kalim, S1
Velasquez, MT1
Ramezani, A1
Manal, A1
Raj, DS1
Weinert, CH1
Empl, MT1
Frommherz, L1
Egert, B1
Steinberg, P1
Williams, PT1
Lamendella, R1
Faghihnia, N1
Grube, A1
Jansson, JK1
Pham, K1
Stremmel, W1
Schmidt, KV1
Schuhmann, V1
Kratzer, F1
Garbade, SF1
Langhans, CD1
Fricker, G1
Okun, JG1
Rak, K1
Rader, DJ1
Klipfell, E1
Bennett, BJ1
Koeth, R1
Dugar, B1
Feldstein, AE1
Chung, YM1
Schauer, P1
Smith, JD1
Lusis, AJ1
Willyard, C1

Clinical Trials (27)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
BASEL VIII Trial - Biochemical and Electrocardiographic Signatures in the Detection of Exercise-induced Myocardial Ischemia[NCT01838148]4,000 participants (Anticipated)Observational2004-05-31Recruiting
Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.[NCT05795946]45 participants (Anticipated)Interventional2023-04-15Recruiting
Concentration of Trimethylamine-N-oxide Versus Echocardiographic, Biochemical and Histopathological Parameters of Heart Failure in Patients With Severe Aortic Stenosis: a Prospective, Observatory Trial[NCT04406805]70 participants (Anticipated)Observational2019-01-15Recruiting
Discovering the Effects of Pulses Through the Gut Microbiome and Bioavailability of Bioactive Compounds[NCT05999136]78 participants (Anticipated)Interventional2023-10-02Recruiting
Impact of Facilitated Vegan Diet on Cardiometabolic Endpoints and Trimethylamine N-oxide[NCT05071196]70 participants (Anticipated)Interventional2022-01-01Active, not recruiting
SWAP-MEAT (Study With Appetizing Plant-Food, Meat Eating Alternatives Trial) Athlete for MC-URC (Menus of Change University Research Collaborative): Three Diets on Athletic Performance[NCT06014307]120 participants (Anticipated)Interventional2023-10-04Recruiting
SWAP-MEAT: Study With Appetizing Plant Food - Meat Eating Alternatives Trial[NCT03718988]38 participants (Actual)Interventional2019-01-17Completed
Nurses' Health Study (Cardiovascular Component)[NCT00005152]121,700 participants (Actual)Observational1980-08-31Active, not recruiting
"Plant-Based Meat vs Animal Red Meat: a Randomized Cross-over Trial"[NCT04510324]41 participants (Actual)Interventional2020-11-01Completed
Investigation on the Effect of Carnitine Supplement on Gut Microbiota and TMAO Production Capacity[NCT02838732]56 participants (Actual)Interventional2016-05-18Completed
A Randomised, Double-blinded, Cross-over, Placebo- Controlled Pilot Study to Investigate the Effect of Tomato Extract on TMAO in Overweight or Obese Adults[NCT04160481]37 participants (Actual)Interventional2019-11-12Completed
Association Analysis of Cardiovascular and Nervous System Diseases and Intestinal Microbiome Based on Multi-omics Big Data and Related Applications[NCT06099496]490 participants (Anticipated)Observational [Patient Registry]2023-04-01Recruiting
Effect of Choline Source and Gut Microbiota Composition on Trimethylamine-N-oxide Response in Humans[NCT04255368]44 participants (Actual)Interventional2017-11-09Completed
Does the Human Gut Microbiome Serve as a Novel Personalized Therapeutic Target for Coronary Atherosclerosis?[NCT03009565]800 participants (Anticipated)Observational2017-01-31Not yet recruiting
GutHeart: Targeting Gut Microbiota to Treat Heart Failure[NCT02637167]Phase 2150 participants (Anticipated)Interventional2016-03-11Recruiting
Gut Flora Metabolite Reduction After Dietary Intervention (GRADY)[NCT02016430]150 participants (Anticipated)Interventional2014-04-04Recruiting
Analysis of MicroBial Metabolites After Eating Refined Food[NCT04308473]46 participants (Actual)Interventional2020-09-01Active, not recruiting
Evaluation of Red Wine Effects Upon Gut Flora and Plasma Levels of Trimethylamine-N-oxide (TMAO) in Patients With Established Atherosclerotic Disease[NCT03232099]42 participants (Actual)Interventional2016-08-31Completed
A Trial of the Ideal Protein System Versus Low Fat Diet for Weight Loss[NCT03515889]192 participants (Actual)Interventional2018-05-23Completed
Effect of Probiotic Supplementation on Endothelial Function II[NCT03267758]215 participants (Anticipated)Interventional2018-05-15Recruiting
Effect of 1 Year Vitamin D or D Plus B-vitamins on Bone Markers in Elderly People[NCT02586181]93 participants (Actual)Interventional2009-08-31Completed
B-Vitamins and Polyneuropathy in Patients With Type 2 Diabetes[NCT02588898]212 participants (Actual)Observational2009-09-30Completed
Effect of Dapagliflozin on Metabolomics and Cardiac Mechanics in Chronic Kidney Disease[NCT05719714]Phase 1/Phase 260 participants (Anticipated)Interventional2023-11-01Recruiting
Low Fat Vegan Diet or American Heart Association Diet, Impact on Biomarkers of Inflammation, Oxidative Stress and Cardiovascular Risk in Obese 9-18 y.o. With Elevated Cholesterol: A Four Week Randomized Trial[NCT01817491]60 participants (Actual)Interventional2013-03-31Completed
Effects of Choline Supplementation on Fetal Growth in Gestational Diabetes Mellitus[NCT04302168]60 participants (Anticipated)Interventional2020-04-01Recruiting
Impact of Diet and Gut Microbiota on Trimethylamine-N-oxide Production and Fate in Humans[NCT02558673]40 participants (Actual)Interventional2014-05-31Completed
Effects of Choline From Eggs vs. Supplements on the Generation of TMAO in Humans (EGGS)[NCT03039023]86 participants (Actual)Interventional2016-09-02Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in PAQ (Physical Activity Questionnaire)

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: baseline, 4 weeks

Interventionunits on a scale (Mean)
Reduced Fat Vegan Diet0.22
American Heart Association Diet-0.16

Children Change in BMI Z Score

Body mass index z-scores, also called BMI standard deviation (s.d.) scores, are measures of relative weight adjusted for child age and sex. Given a child's age, sex, BMI, and an appropriate reference standard, a BMI z-score (or its equivalent BMI-for-age percentile) can be determined. Negative BMI z-scores indicate a BMI that is lower than the population mean, while positive BMI scores indicate a value that is higher than the population mean. A decrease in the BMI z-score over time indicate a lowering of the BMI. Z-scores of 1.03 and 1.64 correspond to the 85th and 95th percentiles of BMI-for-age, which are the definitions of overweight and obesity in children. (NCT01817491)
Timeframe: baseline, 4 weeks

InterventionZ Score (Mean)
Reduced Fat Vegan Diet-0.14
American Heart Association Diet-0.03

PB/AHA - Adjusted Mean Difference BMI Z Score Children

(NCT01817491)
Timeframe: Baseline, 4 weeks

InterventionZ score (Mean)
PB/AHA-0.13

PB/AHA - Adjusted Mean Difference PAQ Children

PAQ self reported questions based on activity level from 1 (low activity) to 5 (high activity), overall PAQ score is a mean of the questions. (NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionunits on a scale (Mean)
PB/AHA0.39

Change in Blood Pressure (BP)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmm Hg (Mean)
Children Systolic BPParents Systolic BPChildren Diastolic BPParent Diastolic BP
American Heart Association Diet-5.14-3.14-4.36-6.64
Reduced Fat Vegan Diet-6.43-7.96-2.61-3.46

Change in Body Mass Index BMI Percentile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionBMI percentile (Mean)
ChildrenParents
American Heart Association Diet-0.08-0.73
Reduced Fat Vegan Diet-1.12-1.29

Change in Circumference

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventioncm (Mean)
Children Waist CircumferenceParents Waist CircumferenceChildren Midarm CircumferenceParents Midarm Circumference
American Heart Association Diet-2.96-0.49-1.140.35
Reduced Fat Vegan Diet-1.53-1.94-2.02-1.32

Change in Glucose

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
ChildrenParent
American Heart Association Diet-.64-5.43
Reduced Fat Vegan Diet0.934.93

Change in HgbA1c (Hemoglobin A1c)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpercentage (Mean)
ChildrenParent
American Heart Association Diet0.210.14
Reduced Fat Vegan Diet0.17-0.16

Change in hsCRP (High-sensitivity C-reactive Protein)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/L (Mean)
ChildrenParent
American Heart Association Diet2.780.21
Reduced Fat Vegan Diet-2.09-0.24

Change in IL-6 (Interleukin-6)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpg/ml (Mean)
ChildrenParent
American Heart Association Diet-0.19-0.19
Reduced Fat Vegan Diet-0.170.16

Change in Insulin

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionuU/ml (Mean)
ChildrenParents
American Heart Association Diet3.16-3.15
Reduced Fat Vegan Diet-5.42-3.11

Change in Lipid Profile

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionmg/dL (Mean)
total cholesterol childrentriglycerides childrenhigh-density lipoprotein cholesterol childrenlow-density lipoprotein cholesterol childrentotal cholesterol parentstriglycerides parentshigh-density lipoprotein cholesterol parentslow-density lipoprotein cholesterol parents
American Heart Association Diet-16.50-13.14-2.93-11.00-7.1416.8616.86-5.50
Reduced Fat Vegan Diet-22.50-25.50-5.93-13.14-33.796.21-8.14-27.00

Change in Liver Enzymes

(NCT01817491)
Timeframe: baseline, 4 weeks

,
InterventionU/L (Mean)
alanine aminotransferase (ALT) childrenaspartate aminotransferase (AST) childrenalanine aminotransferase (ALT) parentsaspartate aminotransferase (AST) parents
American Heart Association Diet-1.140.004.574.43
Reduced Fat Vegan Diet0.792.790.860.14

Change in MPO (Myeloperoxidase)

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionpmol/L (Mean)
ChildrenParent
American Heart Association Diet-69.231.78
Reduced Fat Vegan Diet-75.3416.91

Change in Weight

(NCT01817491)
Timeframe: baseline, 4 weeks

,
Interventionkg (Mean)
ChildrenParents
American Heart Association Diet-1.55-2.01
Reduced Fat Vegan Diet-3.05-3.64

PB/AHA - Adjusted Mean BP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
Children adj mean ratio systolic BPChildren adj mean ratio diastolic BPparents adj mean ratio systolic BPparents adj mean ratio diastolic BP
PB/AHA1.871.010.971.03

PB/AHA - Adjusted Mean Difference BMI

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionpercentile (Mean)
Children Change in BMIParents Change in BMI
PB/AHA-1.17-0.69

PB/AHA - Adjusted Mean Difference Circumference

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventioncm (Mean)
children waist circumferenceparents waist circumferencechildren arm circumferenceparents arm circumference
PB/AHA1.32-1.14-1.25-1.68

PB/AHA - Adjusted Mean Difference Weight

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionkg (Mean)
Children WeightParents Weight
PB/AHA-1.71-1.95

PB/AHA - Adjusted Mean Lipid Profile

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionmg/dL (Mean)
CHOL childrenTRIG childrenHDL childrenLDL childrenCHOL parentsTRIG parentsHDL parentsLDL parents
PB/AHA-10.341.010.170.95-27.290.950.94-21.92

PB/AHA - Adjusted Mean Ratio Glucose

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA1.011.06

PB/AHA - Adjusted Mean Ratio HgbA1c

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.990.96

PB/AHA - Adjusted Mean Ratio hsCRP

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.460.68

PB/AHA - Adjusted Mean Ratio IL-6

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.261.14

PB/AHA - Adjusted Mean Ratio Insulin

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.70.87

PB/AHA - Adjusted Mean Ratio Liver Enzymes

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ALT childrenAST childrenALT parentsAST parents
PB/AHA11.130.850.83

PB/AHA - Adjusted Mean Ratio MPO

(NCT01817491)
Timeframe: Baseline, 4 weeks

Interventionratio (Mean)
ChildrenParents
PB/AHA0.950.93

Changes in Levels of Fasting Trimethylamine-N-oxide (TMAO) in 24-hour Urine Collections

Changes in levels of non-labeled TMAO from baseline to Day 28 measured by established mass spectrometry techniques. (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionmg in 24 hours (Median)
BaselineDay 28
Choline Bitartrate Tablets26.2139.0
Egg Whites + Choline Bitartrate Tablets29.3186.9
Hardboiled Eggs + Choline Bitartrate Tablets27.5221.8
Phosphatidylcholine Capsules15.833.1
Whole Hardboiled Eggs24.328.5

Changes in Lipid Profile, HDL

Changes in measured HDL levels between baseline and Day 28 (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionmg/dL (Median)
BaselineDay 28
Choline Bitartrate Tablets4951
Egg Whites + Choline Bitartrate Tablets4850
Hardboiled Eggs + Choline Bitartrate Tablets5756
Phosphatidylcholine Capsules6162
Whole Hardboiled Eggs4849

Changes in Lipid Profile, LDL

Changes in measured LDL levels between baseline and Day 28 (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionmg/dL (Median)
BaselineDay 28
Choline Bitartrate Tablets9094
Egg Whites + Choline Bitartrate Tablets104101
Hardboiled Eggs + Choline Bitartrate Tablets108118
Phosphatidylcholine Capsules107106
Whole Hardboiled Eggs9186

Changes in Lipid Profile, Total Cholesterol

Changes in total cholesterol levels between baseline and Day 28 (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionmg/dL (Median)
BaselineDay 28
Choline Bitartrate Tablets180172
Egg Whites + Choline Bitartrate Tablets186178
Hardboiled Eggs + Choline Bitartrate Tablets187198
Phosphatidylcholine Capsules175172
Whole Hardboiled Eggs156158

Changes in Lipid Profile, Triglycerides

Changes in measured triglyceride levels between baseline and Day 28 (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionmg/dL (Median)
BaselineDay 28
Choline Bitartrate Tablets10696
Egg Whites + Choline Bitartrate Tablets122109
Hardboiled Eggs + Choline Bitartrate Tablets10397
Phosphatidylcholine Capsules7484
Whole Hardboiled Eggs86100

Changes in Plasma Levels of Fasting Betaine.

Fasting plasma levels of betaine from samples obtained at baseline and at day 28 were compared. (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
InterventionuM (Median)
BaselineDay 28
Choline Bitartrate Tablets38.269.0
Egg Whites + Choline Bitartrate Tablets38.759.8
Hardboiled Eggs + Choline Bitartrate Tablets30.746.9
Phosphatidylcholine Capsules33.646.3
Whole Hardboiled Eggs28.139.7

Changes in Plasma Levels of Fasting Carnitine.

Fasting plasma levels of carnitine from samples obtained at baseline and at day 28 were compared. (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
InterventionuM (Median)
BaselineDay 28
Choline Bitartrate Tablets21.218.7
Egg Whites + Choline Bitartrate Tablets21.118.9
Hardboiled Eggs + Choline Bitartrate Tablets21.515.6
Phosphatidylcholine Capsules23.420.8
Whole Hardboiled Eggs19.119.4

Changes in Plasma Levels of Fasting Choline

Fasting plasma levels of choline from samples obtained at baseline and at day 28 were compared. (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
InterventionuM (Median)
BaselineDay 28
Choline Bitartrate Tablets7.512.9
Egg Whites + Choline Bitartrate Tablets9.512.8
Hardboiled Eggs + Choline Bitartrate Tablets8.514.0
Phosphatidylcholine Capsules7.610.6
Whole Hardboiled Eggs8.310.9

Changes in Plasma Levels of Fasting Trimethylamine-N-oxide (TMAO), a Choline Metabolite

Changes in levels of non-labeled TMAO from baseline to end-of-study (day 28) as measured by established techniques by mass spectrometry. (NCT03039023)
Timeframe: Baseline, 28 days

,,,,
InterventionuM (Median)
BaselineDay 28
Choline Bitartrate Tablets1.911.1
Egg Whites + Choline Bitartrate Tablets2.628.1
Hardboiled Eggs + Choline Bitartrate Tablets2.312.3
Phosphatidylcholine Capsules2.83.4
Whole Hardboiled Eggs2.02.3

Changes in Platelet Function With Increased Choline Intake

The activation and functioning of platelets within a single subject will be compared before and after increased choline intake. (NCT03039023)
Timeframe: Baseline, Day 28

,,,,
Interventionaggregation percentage (Median)
BaselineDay 28
Choline Bitartrate Tablets2.612.8
Egg Whites + Choline Bitartrate Tablets3.029.4
Hardboiled Eggs + Choline Bitartrate Tablets2.312.3
Phosphatidylcholine Capsules2.83.4
Whole Hardboiled Eggs2.63.6

Reviews

71 reviews available for trimethyloxamine and Cardiovascular Diseases

ArticleYear
Polycystic ovary syndrome and cardiovascular risk. Could trimethylamine N-oxide (TMAO) be a major player? A potential upgrade forward in the DOGMA theory.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2021, Volume: 143

    Topics: Animals; Bacteria; Cardiovascular Diseases; Dysbiosis; Female; Gastrointestinal Microbiome; Heart Di

2021
Trimethylamine N-oxide-a marker for atherosclerotic vascular disease.
    Reviews in cardiovascular medicine, 2021, Sep-24, Volume: 22, Issue:3

    Topics: Animals; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Humans; Methylamines

2021
Are eggs good again? A precision nutrition perspective on the effects of eggs on cardiovascular risk, taking into account plasma lipid profiles and TMAO.
    The Journal of nutritional biochemistry, 2022, Volume: 100

    Topics: Bacteria; Biological Variation, Population; Cardiovascular Diseases; Cholesterol; Choline; Diet; Egg

2022
Association of Trimethylamine-N-Oxide Levels with Risk of Cardiovascular Disease and Mortality among Elderly Subjects: A Systematic Review and Meta-Analysis.
    Cardiorenal medicine, 2022, Volume: 12, Issue:2

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Heart Failure; Humans; Methylamines; Oxides; Prospective

2022
Gut microbiota-derived metabolite trimethylamine-N-oxide and multiple health outcomes: an umbrella review and updated meta-analysis.
    The American journal of clinical nutrition, 2022, 07-06, Volume: 116, Issue:1

    Topics: Cardiovascular Diseases; Diabetes Mellitus; Gastrointestinal Microbiome; Humans; Hypertension; Methy

2022
Trimethylamine N-oxide in cardiovascular disease.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2022, Volume: 31, Issue:8

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines

2022
Trimethylamine N-oxide reduction is related to probiotic strain specificity: A systematic review.
    Nutrition research (New York, N.Y.), 2022, Volume: 104

    Topics: Animals; Cardiovascular Diseases; Choline; Gastrointestinal Microbiome; Humans; Methylamines; Probio

2022
[Gut-derived uremic toxin trimethylamine-N-oxide in cardiovascular disease under end-stage renal disease: an injury mechanism and therapeutic target].
    Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi, 2022, Aug-25, Volume: 39, Issue:4

    Topics: Cardiovascular Diseases; Humans; Kidney Failure, Chronic; Methylamines; Oxides; Uremic Toxins

2022
Trimethylamine N-Oxide Generated by the Gut Microbiota: Potential Atherosclerosis Treatment Strategies.
    Current pharmaceutical design, 2022, Volume: 28, Issue:35

    Topics: Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2022
The Role of Gut Microbiota and Trimethylamine N-oxide in Cardiovascular Diseases.
    Journal of cardiovascular translational research, 2023, Volume: 16, Issue:3

    Topics: Cardiovascular Diseases; Coronary Artery Disease; Gastrointestinal Microbiome; Humans; Methylamines;

2023
Trimethylamine N-Oxide as a Potential Risk Factor for Non-communicable Diseases: A Systematic Review.
    Endocrine, metabolic & immune disorders drug targets, 2023, Volume: 23, Issue:5

    Topics: Animals; Cardiovascular Diseases; Cross-Sectional Studies; Noncommunicable Diseases; Risk Factors

2023
Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis?
    Pharmacological research, 2023, Volume: 187

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2023
Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis?
    Pharmacological research, 2023, Volume: 187

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2023
Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis?
    Pharmacological research, 2023, Volume: 187

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2023
Gut microbiome and metabolites, the future direction of diagnosis and treatment of atherosclerosis?
    Pharmacological research, 2023, Volume: 187

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2023
Gut Microbiota-Derived TMAO: A Causal Factor Promoting Atherosclerotic Cardiovascular Disease?
    International journal of molecular sciences, 2023, Jan-18, Volume: 24, Issue:3

    Topics: Atherosclerosis; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines; Prospec

2023
Microbiota Effect on Trimethylamine N-Oxide Production: From Cancer to Fitness-A Practical Preventing Recommendation and Therapies.
    Nutrients, 2023, Jan-21, Volume: 15, Issue:3

    Topics: Animals; Cardiovascular Diseases; Choline; Inflammation; Methylamines; Microbiota; Neoplasms

2023
The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases.
    Frontiers in endocrinology, 2023, Volume: 14

    Topics: Atherosclerosis; Cardiovascular Diseases; Choline; Gastrointestinal Microbiome; Humans; Methylamines

2023
Gut microbiota-derived trimethylamine N-oxide is associated with the risk of all-cause and cardiovascular mortality in patients with chronic kidney disease: a systematic review and dose-response meta-analysis.
    Annals of medicine, 2023, Volume: 55, Issue:1

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Inflammation; Renal Insufficiency, Chr

2023
The interplay between microbial metabolites and macrophages in cardiovascular diseases: A comprehensive review.
    International immunopharmacology, 2023, Volume: 121

    Topics: Atherosclerosis; Cardiovascular Diseases; Cholesterol; Humans; Macrophages; Methylamines

2023
Importance of gut microbiota metabolites in the development of cardiovascular diseases (CVD).
    Life sciences, 2023, Sep-15, Volume: 329

    Topics: Atherosclerosis; Cardiovascular Diseases; Dysbiosis; Gastrointestinal Microbiome; Humans; Inflammati

2023
Gut Microbiota Composition and Cardiovascular Disease: A Potential New Therapeutic Target?
    International journal of molecular sciences, 2023, Jul-26, Volume: 24, Issue:15

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Heart Failure; Humans; Methylamines

2023
The Microbial Metabolite Trimethylamine N-Oxide Links Vascular Dysfunctions and the Autoimmune Disease Rheumatoid Arthritis.
    Nutrients, 2019, Aug-07, Volume: 11, Issue:8

    Topics: Amyloid; Animals; Arthritis, Rheumatoid; Autoimmune Diseases; Cardiovascular Diseases; Diet; Dysbios

2019
The emerging role of gut microbial metabolism on cardiovascular disease.
    Current opinion in microbiology, 2019, Volume: 50

    Topics: Animals; Bacteria; Cardiovascular Diseases; Diet; Gastrointestinal Microbiome; Humans; Metabolomics;

2019
Metabolic endotoxemia and cardiovascular disease: A systematic review about potential roles of prebiotics and probiotics.
    Clinical and experimental pharmacology & physiology, 2020, Volume: 47, Issue:6

    Topics: Animals; Bacteria; Cardiovascular Diseases; Dysbiosis; Endotoxemia; Gastrointestinal Microbiome; Hea

2020
Archaea, specific genetic traits, and development of improved bacterial live biotherapeutic products: another face of next-generation probiotics.
    Applied microbiology and biotechnology, 2020, Volume: 104, Issue:11

    Topics: Animals; Archaea; Biological Therapy; Cardiovascular Diseases; Diet; Gastrointestinal Microbiome; Hu

2020
Trimethylamine N-Oxide in Relation to Cardiometabolic Health-Cause or Effect?
    Nutrients, 2020, May-07, Volume: 12, Issue:5

    Topics: Age Factors; Amines; Animals; Cardiometabolic Risk Factors; Cardiovascular Diseases; Carnitine; Dige

2020
Targeting the human microbiome and its metabolite TMAO in cardiovascular prevention and therapy.
    Pharmacology & therapeutics, 2020, Volume: 213

    Topics: Animals; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Life Style; Methylamines; Mic

2020
Gut microbiota metabolites as integral mediators in cardiovascular diseases (Review).
    International journal of molecular medicine, 2020, Volume: 46, Issue:3

    Topics: Amino Acids; Animals; Bile Acids and Salts; Cardiovascular Diseases; Fatty Acids; Gastrointestinal M

2020
Gut Microbiota and Cardiovascular Disease.
    Circulation research, 2020, 07-31, Volume: 127, Issue:4

    Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cardiovascular Diseases; Carnitine; Choline; Disease

2020
The Relationship between Choline Bioavailability from Diet, Intestinal Microbiota Composition, and Its Modulation of Human Diseases.
    Nutrients, 2020, Aug-05, Volume: 12, Issue:8

    Topics: Animals; Biological Availability; Cardiovascular Diseases; Choline; Diet; Dysbiosis; Gastrointestina

2020
TMAO as a biomarker of cardiovascular events: a systematic review and meta-analysis.
    Internal and emergency medicine, 2021, Volume: 16, Issue:1

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Methylamines; Risk Factors

2021
Molecular Mechanisms Underlying the Cardiovascular Toxicity of Specific Uremic Solutes.
    Cells, 2020, 09-02, Volume: 9, Issue:9

    Topics: Basic Helix-Loop-Helix Transcription Factors; Blood Platelets; Cardiovascular Diseases; Disease Prog

2020
Implication of Gut Microbiota in Cardiovascular Diseases.
    Oxidative medicine and cellular longevity, 2020, Volume: 2020

    Topics: Cardiovascular Diseases; Cell Death; Energy Metabolism; Fatty Acids, Volatile; Gastrointestinal Micr

2020
Understanding connections and roles of gut microbiome in cardiovascular diseases.
    Canadian journal of microbiology, 2021, Volume: 67, Issue:2

    Topics: Bacteria; Bile Acids and Salts; Cardiovascular Diseases; Diet; Fatty Acids, Volatile; Gastrointestin

2021
Gut microbiota-associated trimethylamine N-oxide and increased cardiometabolic risk in adults: a systematic review and dose-response meta-analysis.
    Nutrition reviews, 2021, 08-09, Volume: 79, Issue:9

    Topics: Adult; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines; Risk Factors

2021
Gut microbiota-derived trimethylamine-N-oxide: A bridge between dietary fatty acid and cardiovascular disease?
    Food research international (Ottawa, Ont.), 2020, Volume: 138, Issue:Pt B

    Topics: Cardiovascular Diseases; Fatty Acids; Gastrointestinal Microbiome; Humans; Methylamines; Oxides

2020
Role of Gut Microbiota and Their Metabolites on Atherosclerosis, Hypertension and Human Blood Platelet Function: A Review.
    Nutrients, 2021, Jan-03, Volume: 13, Issue:1

    Topics: Animals; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Fatty Acids, Volatile; Gastroint

2021
Use of dietary phytochemicals for inhibition of trimethylamine N-oxide formation.
    The Journal of nutritional biochemistry, 2021, Volume: 91

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Drug Discovery; Gastrointestinal Microbiome; Huma

2021
Trimethylamine N-Oxide (TMAO), Diet and Cardiovascular Disease.
    Current atherosclerosis reports, 2021, 02-17, Volume: 23, Issue:4

    Topics: Cardiovascular Diseases; Choline; Diet; Humans; Methylamines

2021
Trimethylamine N-oxide (TMAO): a new attractive target to decrease cardiovascular risk.
    Postgraduate medical journal, 2022, Volume: 98, Issue:1163

    Topics: Cardiovascular Diseases; Heart Disease Risk Factors; Humans; Methylamines; Risk Factors

2022
Two Gut Microbiota-Derived Toxins Are Closely Associated with Cardiovascular Diseases: A Review.
    Toxins, 2021, 04-22, Volume: 13, Issue:5

    Topics: Bacterial Toxins; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Lipopolysaccharides;

2021
Trimethylamine/Trimethylamine-N-Oxide as a Key Between Diet and Cardiovascular Diseases.
    Cardiovascular toxicology, 2021, Volume: 21, Issue:8

    Topics: Animals; Bacteria; Cardiovascular Diseases; Diet; Gastrointestinal Microbiome; Heart Disease Risk Fa

2021
Dysbiosis-Related Advanced Glycation Endproducts and Trimethylamine N-Oxide in Chronic Kidney Disease.
    Toxins, 2021, 05-19, Volume: 13, Issue:5

    Topics: Animals; Cardiovascular Diseases; Disease Progression; Dysbiosis; Gastrointestinal Microbiome; Glyca

2021
Nutrients Turned into Toxins: Microbiota Modulation of Nutrient Properties in Chronic Kidney Disease.
    Nutrients, 2017, May-12, Volume: 9, Issue:5

    Topics: Cardiovascular Diseases; Carnitine; Choline; Diet; Gastrointestinal Microbiome; Humans; Methylamines

2017
Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.
    Journal of the American Heart Association, 2017, Jun-29, Volume: 6, Issue:7

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; Gastrointestinal Microbiome; Humans; Meth

2017
Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.
    Journal of the American Heart Association, 2017, Jun-29, Volume: 6, Issue:7

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; Gastrointestinal Microbiome; Humans; Meth

2017
Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.
    Journal of the American Heart Association, 2017, Jun-29, Volume: 6, Issue:7

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; Gastrointestinal Microbiome; Humans; Meth

2017
Gut Microbiota Metabolites and Risk of Major Adverse Cardiovascular Disease Events and Death: A Systematic Review and Meta-Analysis of Prospective Studies.
    Journal of the American Heart Association, 2017, Jun-29, Volume: 6, Issue:7

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; Gastrointestinal Microbiome; Humans; Meth

2017
Circulating trimethylamine N-oxide and the risk of cardiovascular diseases: a systematic review and meta-analysis of 11 prospective cohort studies.
    Journal of cellular and molecular medicine, 2018, Volume: 22, Issue:1

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Female; Humans; Male; Methylamines; Middle Aged; P

2018
The role of trimethylamine N-oxide as a mediator of cardiovascular complications in chronic kidney disease.
    Kidney international, 2017, Volume: 92, Issue:4

    Topics: Biomarkers; Cardiovascular Diseases; Diet Therapy; Gastrointestinal Microbiome; Humans; Kidney; Lipi

2017
Gut microbe-generated metabolite trimethylamine-N-oxide as cardiovascular risk biomarker: a systematic review and dose-response meta-analysis.
    European heart journal, 2017, Oct-14, Volume: 38, Issue:39

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; Dose-Response Relationship, Drug; Female;

2017
The gut microbiota: An emerging risk factor for cardiovascular and cerebrovascular disease.
    European journal of immunology, 2018, Volume: 48, Issue:4

    Topics: Animals; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Cerebrovascular Disorders; Gastr

2018
Red meat intake in chronic kidney disease patients: Two sides of the coin.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 46

    Topics: Cardiovascular Diseases; Diet, Protein-Restricted; Dietary Fats; Dietary Proteins; Gastrointestinal

2018
Trimethylamine N-oxide: A harmful, protective or diagnostic marker in lifestyle diseases?
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 46

    Topics: Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diet; Gastrointestinal Microbiome; Homeostas

2018
The gut microbiota as a novel regulator of cardiovascular function and disease.
    The Journal of nutritional biochemistry, 2018, Volume: 56

    Topics: Aging; Animals; Anti-Bacterial Agents; Atherosclerosis; Bile Acids and Salts; Cardiovascular Disease

2018
Contributory Role of Gut Microbiota and Their Metabolites Toward Cardiovascular Complications in Chronic Kidney Disease.
    Seminars in nephrology, 2018, Volume: 38, Issue:2

    Topics: Animals; Cardiovascular Diseases; Cresols; Diet Therapy; Dietary Supplements; Dysbiosis; Enzyme Inhi

2018
Lipids, Apolipoproteins, and Inflammatory Biomarkers of Cardiovascular Risk: What Have We Learned?
    Clinical pharmacology and therapeutics, 2018, Volume: 104, Issue:2

    Topics: Animals; Apolipoproteins; Biomarkers; Cardiovascular Diseases; Dyslipidemias; Gastrointestinal Micro

2018
Implication of Trimethylamine N-Oxide (TMAO) in Disease: Potential Biomarker or New Therapeutic Target.
    Nutrients, 2018, Oct-01, Volume: 10, Issue:10

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Inflammation Mediators; Metabolic Networks and Pathways

2018
Trimethylamine N-Oxide and Risk of Cardiovascular Disease and Mortality.
    Current nutrition reports, 2018, Volume: 7, Issue:4

    Topics: Animals; Bacteria; Biomarkers; Cardiovascular Diseases; Cause of Death; Gastrointestinal Microbiome;

2018
Interaction between gut microbiome and cardiovascular disease.
    Life sciences, 2018, Dec-01, Volume: 214

    Topics: Cardiovascular Diseases; Fatty Acids, Volatile; Fecal Microbiota Transplantation; Gastrointestinal M

2018
The Role of Microbiota in Cardiovascular Risk: Focus on Trimethylamine Oxide.
    Current problems in cardiology, 2019, Volume: 44, Issue:6

    Topics: Cardiovascular Diseases; Cause of Death; Global Health; Humans; Methylamines; Microbiota; Morbidity;

2019
The role of intestinal microbiota in cardiovascular disease.
    Journal of cellular and molecular medicine, 2019, Volume: 23, Issue:4

    Topics: Bile Acids and Salts; Cardiovascular Diseases; Dysbiosis; Fatty Acids; Gastrointestinal Microbiome;

2019
Modulation of Circulating Trimethylamine N-Oxide Concentrations by Dietary Supplements and Pharmacological Agents: A Systematic Review.
    Advances in nutrition (Bethesda, Md.), 2019, 09-01, Volume: 10, Issue:5

    Topics: Anti-Bacterial Agents; Antioxidants; Cardiovascular Diseases; Carnitine; Choline; Dietary Supplement

2019
The Gut Microbial Metabolite Trimethylamine N-Oxide and Hypertension Risk: A Systematic Review and Dose-Response Meta-analysis.
    Advances in nutrition (Bethesda, Md.), 2020, 01-01, Volume: 11, Issue:1

    Topics: Adult; Aged; Bacteria; Cardiovascular Diseases; Female; Gastrointestinal Microbiome; Humans; Hyperte

2020
Gut microbiota metabolism of L-carnitine and cardiovascular risk.
    Atherosclerosis, 2013, Volume: 231, Issue:2

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Dietary Supplements; Humans; Ins

2013
Metaorganismal nutrient metabolism as a basis of cardiovascular disease.
    Current opinion in lipidology, 2014, Volume: 25, Issue:1

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Humans; Methylamines; Risk

2014
The contributory role of gut microbiota in cardiovascular disease.
    The Journal of clinical investigation, 2014, Volume: 124, Issue:10

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Choline; Diet; Female; Food; Humans; I

2014
The gut microbial endocrine organ: bacterially derived signals driving cardiometabolic diseases.
    Annual review of medicine, 2015, Volume: 66

    Topics: Bacteria; Cardiovascular Diseases; Diet; Endocrine System; Humans; Intestines; Methylamines; Microbi

2015
Egg phospholipids and cardiovascular health.
    Nutrients, 2015, Apr-13, Volume: 7, Issue:4

    Topics: Animals; Biomarkers; Cardiovascular Diseases; Cardiovascular System; Cholesterol, HDL; Diet; Eggs; G

2015
Trimethylamine N-Oxide From Gut Microbiota in Chronic Kidney Disease Patients: Focus on Diet.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2015, Volume: 25, Issue:6

    Topics: Animals; Cardiovascular Diseases; Carnitine; Choline; Diet, Protein-Restricted; Disease Models, Anim

2015
The gut microbiome, diet, and links to cardiometabolic and chronic disorders.
    Nature reviews. Nephrology, 2016, Volume: 12, Issue:3

    Topics: Animals; Biomarkers; Cardiovascular Diseases; Chronic Disease; Diet; Gastrointestinal Microbiome; Hu

2016
Trimethylamine and Trimethylamine N-Oxide, a Flavin-Containing Monooxygenase 3 (FMO3)-Mediated Host-Microbiome Metabolic Axis Implicated in Health and Disease.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:11

    Topics: Animals; Cardiovascular Diseases; Gastrointestinal Microbiome; Host-Pathogen Interactions; Humans; M

2016
Microbiome, trimethylamine N-oxide, and cardiometabolic disease.
    Translational research : the journal of laboratory and clinical medicine, 2017, Volume: 179

    Topics: Animals; Cardiovascular Diseases; Humans; Metabolic Diseases; Methylamines; Microbiota

2017
The Metabolite Trimethylamine-N-Oxide is an Emergent Biomarker of Human Health.
    Current medicinal chemistry, 2017, Nov-24, Volume: 24, Issue:36

    Topics: Animals; Biomarkers; Cardiovascular Diseases; Drugs, Chinese Herbal; Humans; Kidney Diseases; Methyl

2017
An overview of renal metabolomics.
    Kidney international, 2017, Volume: 91, Issue:1

    Topics: Acute Kidney Injury; Analytic Sample Preparation Methods; Cardiovascular Diseases; Diabetic Nephropa

2017
Trimethylamine N-Oxide: The Good, the Bad and the Unknown.
    Toxins, 2016, 11-08, Volume: 8, Issue:11

    Topics: Animals; Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines; Renal Insuffici

2016

Trials

12 trials available for trimethyloxamine and Cardiovascular Diseases

ArticleYear
Protein Intake at Twice the RDA in Older Men Increases Circulatory Concentrations of the Microbiome Metabolite Trimethylamine-N-Oxide (TMAO).
    Nutrients, 2019, Sep-12, Volume: 11, Issue:9

    Topics: Aged; Biomarkers; Cardiovascular Diseases; Cholesterol, LDL; Diet, High-Protein; Dietary Proteins; F

2019
Association of trimethylamine N-oxide with coronary atherosclerotic burden in patients with non-ST-segment elevation myocardial infarction.
    Medicine, 2020, Jul-02, Volume: 99, Issue:27

    Topics: Adolescent; Adult; Aged; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Coronary Artery Disea

2020
Effect of Choline Forms and Gut Microbiota Composition on Trimethylamine-
    Nutrients, 2020, Jul-25, Volume: 12, Issue:8

    Topics: Adult; Biomarkers; Cardiovascular Diseases; Choline; Cross-Over Studies; Diet; Dietary Supplements;

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
A randomized crossover trial on the effect of plant-based compared with animal-based meat on trimethylamine-N-oxide and cardiovascular disease risk factors in generally healthy adults: Study With Appetizing Plantfood-Meat Eating Alternative Trial (SWAP-ME
    The American journal of clinical nutrition, 2020, 11-11, Volume: 112, Issue:5

    Topics: Adult; Animals; Cardiovascular Diseases; Cattle; Chickens; Cross-Over Studies; Diet, Vegetarian; Exe

2020
Gut, microbiota-dependent trimethylamine-N-oxide is associated with long-term all-cause mortality in patients with exacerbated chronic obstructive pulmonary disease.
    Nutrition (Burbank, Los Angeles County, Calif.), 2018, Volume: 45

    Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Female; Gastrointestinal Microbiome; H

2018
Plasma Metabolites From Choline Pathway and Risk of Cardiovascular Disease in the PREDIMED (Prevention With Mediterranean Diet) Study.
    Journal of the American Heart Association, 2017, Oct-28, Volume: 6, Issue:11

    Topics: Aged; Aged, 80 and over; Betaine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chi-Squ

2017
Compared to an Oatmeal Breakfast, Two Eggs/Day Increased Plasma Carotenoids and Choline without Increasing Trimethyl Amine N-Oxide Concentrations.
    Journal of the American College of Nutrition, 2018, Volume: 37, Issue:2

    Topics: Adolescent; Adult; Antioxidants; Avena; Biomarkers; Breakfast; Cardiovascular Diseases; Carotenoids;

2018
The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results from a Randomized Crossover Intervention Study.
    Molecular nutrition & food research, 2019, Volume: 63, Issue:1

    Topics: Adolescent; Adult; Aged; Cardiovascular Diseases; Cross-Over Studies; Diet; Feces; Female; Gastroint

2019
Lactofermented Annurca Apple Puree as a Functional Food Indicated for the Control of Plasma Lipid and Oxidative Amine Levels: Results from a Randomised Clinical Trial.
    Nutrients, 2019, Jan-09, Volume: 11, Issue:1

    Topics: Adolescent; Adult; Aged; Blood Glucose; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL;

2019
Effects of Grape Pomace Polyphenolic Extract (Taurisolo
    Nutrients, 2019, Jan-10, Volume: 11, Issue:1

    Topics: Adult; Bacteria; Cardiovascular Diseases; Cross-Over Studies; Dietary Supplements; Double-Blind Meth

2019
Trimethylamine N-Oxide and Cardiovascular Events in Hemodialysis Patients.
    Journal of the American Society of Nephrology : JASN, 2017, Volume: 28, Issue:1

    Topics: Black People; Cardiovascular Diseases; Female; Humans; Male; Methylamines; Middle Aged; Prospective

2017
Diets high in resistant starch increase plasma levels of trimethylamine-N-oxide, a gut microbiome metabolite associated with CVD risk.
    The British journal of nutrition, 2016, Volume: 116, Issue:12

    Topics: Adult; Biomarkers; Body Mass Index; California; Cardiovascular Diseases; Cross-Over Studies; Diet, C

2016

Other Studies

91 other studies available for trimethyloxamine and Cardiovascular Diseases

ArticleYear
Association of plasma trimethylamine N-oxide levels with atherosclerotic cardiovascular disease and factors of the metabolic syndrome.
    Atherosclerosis, 2021, Volume: 335

    Topics: Adult; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Humans; Metabolic Syndrome; Methylamine

2021
Trimethylamine
    International journal of molecular sciences, 2021, Oct-15, Volume: 22, Issue:20

    Topics: Animals; Cardiovascular Diseases; Cells, Cultured; Gene Expression Regulation; Hep G2 Cells; Humans;

2021
Trimethylamine-N-oxide (TMAO) and clinical outcomes in patients with end-stage kidney disease receiving peritoneal dialysis.
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2022, Volume: 42, Issue:6

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Kidney Failure, Chronic; Oxides; Peritoneal Dialysis; P

2022
The Dietary Nutrient Trimethylamine
    The journal of physical chemistry letters, 2021, Dec-30, Volume: 12, Issue:51

    Topics: Animals; Cardiovascular Diseases; Dietary Supplements; Humans; Lipid Bilayers; Methylamines; Nutrien

2021
The microbial gbu gene cluster links cardiovascular disease risk associated with red meat consumption to microbiota L-carnitine catabolism.
    Nature microbiology, 2022, Volume: 7, Issue:1

    Topics: Animals; Cardiovascular Diseases; Carnitine; Clostridiales; Feces; Female; Gastrointestinal Microbio

2022
Gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and cardiovascular risk in patients with suspected functionally relevant coronary artery disease (fCAD).
    Clinical research in cardiology : official journal of the German Cardiac Society, 2022, Volume: 111, Issue:6

    Topics: Betaine; Cardiovascular Diseases; Carnitine; Choline; Coronary Artery Disease; Gastrointestinal Micr

2022
Association of Uremic Solutes With Cardiovascular Death in Diabetic Kidney Disease.
    American journal of kidney diseases : the official journal of the National Kidney Foundation, 2022, Volume: 80, Issue:4

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Diabetes Mellitus; Diabetic Nephropathies; Humans; Me

2022
Transferrin predicts trimethylamine-N-oxide levels and is a potential biomarker of cardiovascular disease.
    BMC cardiovascular disorders, 2022, 05-10, Volume: 22, Issue:1

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Methylamines; Oxides; Transferrin

2022
Association of Trimethylamine N-Oxide and Metabolites With Mortality in Older Adults.
    JAMA network open, 2022, 05-02, Volume: 5, Issue:5

    Topics: Aged; Betaine; Cardiovascular Diseases; Carnitine; Choline; Cohort Studies; Female; Humans; Male; Me

2022
Citrulline and long-term mortality in patients with cardiovascular disease.
    Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 2022, Volume: 31, Issue:10

    Topics: Acute Coronary Syndrome; Biomarkers; Cardiovascular Diseases; Citrulline; Female; Humans; Male; Midd

2022
Relation of Statin Use to Gut Microbial Trimethylamine N-Oxide and Cardiovascular Risk.
    The American journal of cardiology, 2022, 09-01, Volume: 178

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Heart Disease Risk Factors; Humans; Hydroxymet

2022
Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study.
    Arteriosclerosis, thrombosis, and vascular biology, 2022, Volume: 42, Issue:9

    Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Humans; Meat; Methylamines; Risk Facto

2022
All-Cause Mortality and Trimethylamine N-Oxide Levels in Patients with Cardiovascular Disease.
    Cardiology, 2022, Volume: 147, Issue:4

    Topics: Atrial Fibrillation; Biomarkers; Cardiovascular Diseases; Female; Heart Failure; Humans; Male; Methy

2022
Serum Trimethylamine N-Oxide Level Is Associated with Peripheral Arterial Stiffness in Advanced Non-Dialysis Chronic Kidney Disease Patients.
    Toxins, 2022, 07-31, Volume: 14, Issue:8

    Topics: Ankle Brachial Index; C-Reactive Protein; Cardiovascular Diseases; Humans; Methylamines; Pulse Wave

2022
Increased plasma trimethylamine-
    Food & function, 2022, Oct-03, Volume: 13, Issue:19

    Topics: Aged; Biomarkers; Blood Glucose; Cardiovascular Diseases; Cognitive Dysfunction; Heart Disease Risk

2022
Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice.
    The Journal of physiology, 2022, Volume: 600, Issue:21

    Topics: Aging; Animals; Butanols; Cardiovascular Diseases; Drinking Water; Endothelium, Vascular; Humans; Mi

2022
TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis.
    International journal of molecular sciences, 2022, Oct-11, Volume: 23, Issue:20

    Topics: Animals; Atherosclerosis; Betaine; Cardiovascular Diseases; Carnitine; Choline; Humans; Inflammation

2022
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Aorta- and liver-generated TMAO enhances trained immunity for increased inflammation via ER stress/mitochondrial ROS/glycolysis pathways.
    JCI insight, 2023, 01-10, Volume: 8, Issue:1

    Topics: Animals; Aorta; Cardiovascular Diseases; Endothelial Cells; Humans; Inflammation; Intercellular Adhe

2023
Association of Circulating Trimethylamine-N Oxide With Malnutrition and the Risk of Coronary Artery Disease in Patients With Maintenance Hemodialysis.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2023, Volume: 33, Issue:3

    Topics: Cardiovascular Diseases; Coronary Artery Disease; Humans; Malnutrition; Oxides; Renal Dialysis

2023
Trimethylamine N-oxide is associated with long-term mortality risk: the multi-ethnic study of atherosclerosis.
    European heart journal, 2023, 05-07, Volume: 44, Issue:18

    Topics: Adult; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Dementia; Humans; Methylamines; Neoplas

2023
Cardiovascular disease risk prediction in scleroderma.
    Revista da Associacao Medica Brasileira (1992), 2023, Volume: 69, Issue:2

    Topics: Biomarkers; Cardiac Myosins; Cardiovascular Diseases; Female; Humans; Troponin T

2023
Choline and trimethylamine N-oxide supplementation in normal chow diet and western diet promotes the development of atherosclerosis in Apoe -/- mice through different mechanisms.
    International journal of food sciences and nutrition, 2023, Volume: 74, Issue:2

    Topics: Animals; Apolipoproteins E; Atherosclerosis; Cardiovascular Diseases; Choline; Diet, Western; Dietar

2023
A gut microbiome metabolite paradoxically depresses contractile function while activating mitochondrial respiration.
    Disease models & mechanisms, 2023, 05-01, Volume: 16, Issue:5

    Topics: Animals; Cardiovascular Diseases; Gastrointestinal Microbiome; Glycogen Synthase Kinase 3 beta; Male

2023
Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome.
    Molecules (Basel, Switzerland), 2023, Apr-29, Volume: 28, Issue:9

    Topics: Animals; Cardiovascular Diseases; Cathepsin B; Cells, Cultured; Chromatography, High Pressure Liquid

2023
Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023, Nov-30, Volume: 38, Issue:12

    Topics: Arginine; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Cohort Studies; Diabetes Mellitus; D

2023
Identification of Polymethoxyflavones (PMFs) from Orange Peel and Their Inhibitory Effects on the Formation of Trimethylamine (TMA) and Trimethylamine-N-oxide (TMAO) Using cntA/B and cutC/D Enzymes and Molecular Docking.
    Journal of agricultural and food chemistry, 2023, Nov-01, Volume: 71, Issue:43

    Topics: Cardiovascular Diseases; Citrus sinensis; Methylamines; Molecular Docking Simulation; Oxides

2023
Trimethylamine But Not Trimethylamine Oxide Increases With Age in Rat Plasma and Affects Smooth Muscle Cells Viability.
    The journals of gerontology. Series A, Biological sciences and medical sciences, 2020, 06-18, Volume: 75, Issue:7

    Topics: Age Factors; Animals; Cardiovascular Diseases; Cell Culture Techniques; Cell Survival; Gastrointesti

2020
TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology.
    Toxins, 2019, 08-26, Volume: 11, Issue:9

    Topics: Adult; Aged; Animals; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Cell Survival; Cell

2019
Circulating gut microbiota metabolite trimethylamine N-oxide and oral contraceptive use in polycystic ovary syndrome.
    Clinical endocrinology, 2019, Volume: 91, Issue:6

    Topics: Adolescent; Adult; Betaine; Blood Glucose; Cardiovascular Diseases; Carnitine; Choline; Female; Gast

2019
[Trimethylamine-N-oxide and cardiovascular events in chronic kidney disease].
    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2019, Nov-28, Volume: 44, Issue:11

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Methylamines; Oxides; Renal Insufficiency, Chronic

2019
Trimethylamine N-Oxide and Adenosine Diphosphate-Induced Platelet Reactivity Are Independent Risk Factors for Cardiovascular and All-Cause Mortality.
    Circulation research, 2020, 02-28, Volume: 126, Issue:5

    Topics: Biomarkers; Cardiovascular Diseases; Humans; Methylamines; Mortality; Platelet Activation; Thrombosi

2020
Serum Trimethylamine-N-oxide Concentrations in People Living with HIV and the Effect of Probiotic Supplementation.
    International journal of antimicrobial agents, 2020, Volume: 55, Issue:4

    Topics: Adult; Anti-Retroviral Agents; Atherosclerosis; Biomarkers; Cardiovascular Diseases; Carotid Intima-

2020
Associations of plasma trimethylamine N-oxide, choline, carnitine, and betaine with inflammatory and cardiometabolic risk biomarkers and the fecal microbiome in the Multiethnic Cohort Adiposity Phenotype Study.
    The American journal of clinical nutrition, 2020, 06-01, Volume: 111, Issue:6

    Topics: Adiposity; Aged; Bacteria; Betaine; Biomarkers; Cardiovascular Diseases; Carnitine; Choline; Cohort

2020
[Research progress of targeting gut microbiota-TMA-TMAO pathway in cardiovascular diseases].
    Zhonghua xin xue guan bing za zhi, 2020, Feb-24, Volume: 48, Issue:2

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines

2020
Plasma Trimethylamine N-Oxide and Risk of Cardiovascular Events in Patients With Type 2 Diabetes.
    The Journal of clinical endocrinology and metabolism, 2020, 07-01, Volume: 105, Issue:7

    Topics: Aged; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Female; Humans; Male; Methylamines; Middle

2020
Population studies of TMAO and its precursors may help elucidate mechanisms.
    The American journal of clinical nutrition, 2020, 06-01, Volume: 111, Issue:6

    Topics: Adiposity; Betaine; Biomarkers; Cardiovascular Diseases; Carnitine; Choline; Humans; Methylamines; M

2020
    British journal of neurosurgery, 2021, Volume: 35, Issue:2

    Topics: Aged; Amines; Amino Acids; Biomarkers; Carbonic Anhydrases; Cardiovascular Diseases; Catalysis; Cros

2021
TMAO: Trimethylamine-N-Oxide or Time to Minimize Intake of Animal Products?
    The Journal of clinical endocrinology and metabolism, 2020, 12-01, Volume: 105, Issue:12

    Topics: Animals; Cardiovascular Diseases; Diabetes Mellitus, Type 2; Humans; Methylamines; Oxides; Plasma

2020
Trimethylamine
    Nutrition research reviews, 2021, Volume: 34, Issue:1

    Topics: Cardiovascular Diseases; Gastrointestinal Microbiome; Humans; Methylamines; Microbiota

2021
Association of trimethylamine
    Renal failure, 2020, Volume: 42, Issue:1

    Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Cause of Death; China; Comorbidity; Female; Humans

2020
Trimethylamine N-Oxide, a Gut Microbiota-Dependent Metabolite, is Associated with Frailty in Older Adults with Cardiovascular Disease.
    Clinical interventions in aging, 2020, Volume: 15

    Topics: Aged; Aged, 80 and over; Biomarkers; Cardiovascular Diseases; Cognition Disorders; Cross-Sectional S

2020
Trimethylamine N-oxide and the reverse cholesterol transport in cardiovascular disease: a cross-sectional study.
    Scientific reports, 2020, 10-29, Volume: 10, Issue:1

    Topics: Aged; Biological Transport; Cardiovascular Diseases; Case-Control Studies; Cholesterol; Cholesterol

2020
Insights in the regulation of trimetylamine N-oxide production using a comparative biomimetic approach suggest a metabolic switch in hibernating bears.
    Scientific reports, 2020, 11-23, Volume: 10, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Animals; Betaine; Biomimetics; Cardiovascular Diseases; Choline; Fem

2020
Plasma trimethylamine N-oxide and its metabolic precursors and risk of mortality, cardiovascular and renal disease in individuals with type 2-diabetes and albuminuria.
    PloS one, 2021, Volume: 16, Issue:3

    Topics: Aged; Albuminuria; Biomarkers; Cardiovascular Diseases; Cohort Studies; Denmark; Diabetes Mellitus,

2021
Dietary factors, gut microbiota, and serum trimethylamine-N-oxide associated with cardiovascular disease in the Hispanic Community Health Study/Study of Latinos.
    The American journal of clinical nutrition, 2021, 06-01, Volume: 113, Issue:6

    Topics: Adult; Aged; Biomarkers; Cardiovascular Diseases; Cross-Sectional Studies; Diet; Female; Gastrointes

2021
Trimethylamine N-oxide variation in humans: the product of a diet-microbiota interaction?
    The American journal of clinical nutrition, 2021, 06-01, Volume: 113, Issue:6

    Topics: Cardiovascular Diseases; Diet; Gastrointestinal Microbiome; Hispanic or Latino; Humans; Methylamines

2021
Interplay between diet and gut microbiome, and circulating concentrations of trimethylamine N-oxide: findings from a longitudinal cohort of US men.
    Gut, 2022, Volume: 71, Issue:4

    Topics: Cardiovascular Diseases; Choline; Diet; Gastrointestinal Microbiome; Humans; Male; Methylamines

2022
Gut microbiota-generated metabolite, trimethylamine-N-oxide, and subclinical myocardial damage: a multicenter study from Thailand.
    Scientific reports, 2021, 07-22, Volume: 11, Issue:1

    Topics: Aged; Aged, 80 and over; Atherosclerosis; Cardiovascular Diseases; Case-Control Studies; Female; Gas

2021
Pathogenic Mechanisms of Trimethylamine N-Oxide-induced Atherosclerosis and Cardiomyopathy.
    Current vascular pharmacology, 2022, Volume: 20, Issue:1

    Topics: Animals; Atherosclerosis; Betaine; Cardiomyopathies; Cardiovascular Diseases; Humans; Methylamines

2022
HIV-infected persons with type 2 diabetes show evidence of endothelial dysfunction and increased inflammation.
    BMC infectious diseases, 2017, 03-29, Volume: 17, Issue:1

    Topics: Arginine; Biomarkers; Cardiovascular Diseases; Case-Control Studies; Chromatography, High Pressure L

2017
NMR quantification of trimethylamine-N-oxide in human serum and plasma in the clinical laboratory setting.
    Clinical biochemistry, 2017, Volume: 50, Issue:16-17

    Topics: Adult; Cardiovascular Diseases; Female; Humans; Magnetic Resonance Spectroscopy; Male; Methylamines;

2017
Microbiota-dependent metabolite and cardiovascular disease marker trimethylamine-N-oxide (TMAO) is associated with monocyte activation but not platelet function in untreated HIV infection.
    BMC infectious diseases, 2017, 06-23, Volume: 17, Issue:1

    Topics: Adult; Betaine; Biomarkers; Blood Platelets; Cardiovascular Diseases; Carnitine; Choline; Cross-Sect

2017
What Are Missing Parts in the Research Story of Trimethylamine-N-oxide (TMAO)?
    Journal of agricultural and food chemistry, 2017, Jul-05, Volume: 65, Issue:26

    Topics: Animals; Cardiovascular Diseases; Cattle; Gastrointestinal Microbiome; Humans; Intestinal Mucosa; In

2017
Associations of current diet with plasma and urine TMAO in the KarMeN study: direct and indirect contributions.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:11

    Topics: Adult; Animals; Biomarkers; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Cross-Sec

2017
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
    JCI insight, 2018, 03-22, Volume: 3, Issue:6

    Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo

2018
The microbial metabolite trimethylamine-N-oxide in association with inflammation and microbial dysregulation in three HIV cohorts at various disease stages.
    AIDS (London, England), 2018, 07-31, Volume: 32, Issue:12

    Topics: Adult; Aged; Bacterial Translocation; Cardiovascular Diseases; Cluster Analysis; DNA, Bacterial; DNA

2018
Gut Microbiota-Dependent Trimethylamine N-Oxide Predicts Risk of Cardiovascular Events in Patients With Stroke and Is Related to Proinflammatory Monocytes.
    Arteriosclerosis, thrombosis, and vascular biology, 2018, Volume: 38, Issue:9

    Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Brain Ischemia; Cardiovascular Disea

2018
A Multi-omic Association Study of Trimethylamine N-Oxide.
    Cell reports, 2018, 07-24, Volume: 24, Issue:4

    Topics: Atherosclerosis; Cardiovascular Diseases; Female; Gastrointestinal Microbiome; Humans; Male; Methyla

2018
Loop diuretics decrease the renal elimination rate and increase the plasma levels of trimethylamine-N-oxide.
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:11

    Topics: Aged; Animals; Biomarkers; Cardiovascular Agents; Cardiovascular Diseases; Cross-Sectional Studies;

2018
Identification of TMAO-producer phenotype and host-diet-gut dysbiosis by carnitine challenge test in human and germ-free mice.
    Gut, 2019, Volume: 68, Issue:8

    Topics: Animals; Cardiovascular Diseases; Carnitine; Diet; Dysbiosis; Feeding Behavior; Gastrointestinal Mic

2019
Serum gut microbe-dependent trimethylamine N-oxide improves the prediction of future cardiovascular disease in a community-based general population.
    Atherosclerosis, 2019, Volume: 280

    Topics: Aged; Cardiovascular Diseases; Case-Control Studies; Chromatography, Liquid; Female; Follow-Up Studi

2019
Trimethylamine
    Clinical journal of the American Society of Nephrology : CJASN, 2019, 02-07, Volume: 14, Issue:2

    Topics: Adult; Aged; Angina, Unstable; Calcimimetic Agents; Cardiovascular Diseases; Cinacalcet; Female; Hos

2019
Impact of acute choline loading on circulating trimethylamine N-oxide levels.
    European journal of preventive cardiology, 2019, Volume: 26, Issue:17

    Topics: Biomarkers; Cardiovascular Diseases; Choline; Diet; Healthy Volunteers; Humans; Lipotropic Agents; M

2019
Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers.
    Nutrition, metabolism, and cardiovascular diseases : NMCD, 2019, Volume: 29, Issue:5

    Topics: Amino Acids, Branched-Chain; Bacteria; Biomarkers; Cardiovascular Diseases; Diet, Fat-Restricted; Di

2019
TMAO and Heart Disease: The New Red Meat Risk?
    JAMA, 2019, Jun-11, Volume: 321, Issue:22

    Topics: Cardiovascular Diseases; Carnitine; Diet; Fatty Acids; Gastrointestinal Microbiome; Humans; Methylam

2019
Microbial metabolites as predictive biomarkers: a paradigm shift for cardiovascular risk stratification.
    European heart journal, 2019, 08-21, Volume: 40, Issue:32

    Topics: Acute Coronary Syndrome; Biomarkers; Cardiovascular Diseases; Humans; Lysine; Methylamines; Prognosi

2019
Is increased plasma TMAO a compensatory response to hydrostatic and osmotic stress in cardiovascular diseases?
    Medical hypotheses, 2019, Volume: 130

    Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Carnitine; Choline; Diet; Humans; Hydrostat

2019
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Administration, Oral; Aged; Anti-Bacterial Agents; Betaine; Cardiovascular Diseases; Choline; Female

2013
Gut microbiota, the genome, and diet in atherogenesis.
    The New England journal of medicine, 2013, Apr-25, Volume: 368, Issue:17

    Topics: Anti-Bacterial Agents; Cardiovascular Diseases; Female; Humans; Intestines; Male; Metagenome; Methyl

2013
Gut microbiota: an environmental risk factor for cardiovascular disease.
    Atherosclerosis, 2013, Volume: 229, Issue:2

    Topics: Cardiovascular Diseases; Choline; Diet, Mediterranean; Environment; Environmental Pollutants; Humans

2013
Risk factors for cardiovascular disease: a cautionary tale of diet-microbiome interactions.
    Journal of the American College of Nutrition, 2013, Volume: 32, Issue:2

    Topics: Cardiovascular Diseases; Carnitine; Choline; Diet; Gastrointestinal Tract; Humans; Methylamines; Mic

2013
Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide.
    European heart journal, 2014, Volume: 35, Issue:14

    Topics: Animals; Betaine; Cardiovascular Diseases; Choline; Female; Humans; Intestinal Mucosa; Kaplan-Meier

2014
Intestinal microbiota produced trimethylamine-N-oxide can increase the risk of cardiovascular disease.
    JPMA. The Journal of the Pakistan Medical Association, 2014, Volume: 64, Issue:4

    Topics: Cardiovascular Diseases; Humans; Intestinal Mucosa; Intestines; Methylamines; Microbiota; Oxidants;

2014
Betaine and Trimethylamine-N-Oxide as Predictors of Cardiovascular Outcomes Show Different Patterns in Diabetes Mellitus: An Observational Study.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Acute Coronary Syndrome; Aged; Aged, 80 and over; Betaine; Biomarkers; Cardiovascular Diseases; Case

2014
Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis.
    Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation, 2015, Volume: 25, Issue:4

    Topics: Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, Liquid; Cohort Studies; Com

2015
The Relationship Between Trimethylamine-N-Oxide and Prevalent Cardiovascular Disease in a Multiethnic Population Living in Canada.
    The Canadian journal of cardiology, 2015, Volume: 31, Issue:9

    Topics: Canada; Cardiovascular Diseases; Cross-Sectional Studies; Female; Humans; Male; Methylamines; Middle

2015
High mass accuracy assay for trimethylamine N-oxide using stable-isotope dilution with liquid chromatography coupled to orthogonal acceleration time of flight mass spectrometry with multiple reaction monitoring.
    Analytical and bioanalytical chemistry, 2016, Volume: 408, Issue:3

    Topics: Aged; Aged, 80 and over; Cardiovascular Diseases; Cohort Studies; Female; Humans; Indicator Dilution

2016
Serum Trimethylamine-N-Oxide Is Strongly Related to Renal Function and Predicts Outcome in Chronic Kidney Disease.
    PloS one, 2016, Volume: 11, Issue:1

    Topics: Adult; Aged; Betaine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Choline; Female; Fibr

2016
Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:3

    Topics: Aged; Bacteria; Betaine; Cardiovascular Diseases; Choline; Creatinine; Diabetes Mellitus; Female; Ga

2016
Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:3

    Topics: Aged; Bacteria; Betaine; Cardiovascular Diseases; Choline; Creatinine; Diabetes Mellitus; Female; Ga

2016
Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:3

    Topics: Aged; Bacteria; Betaine; Cardiovascular Diseases; Choline; Creatinine; Diabetes Mellitus; Female; Ga

2016
Plasma trimethylamine N-oxide concentration is associated with choline, phospholipids, and methyl metabolism.
    The American journal of clinical nutrition, 2016, Volume: 103, Issue:3

    Topics: Aged; Bacteria; Betaine; Cardiovascular Diseases; Choline; Creatinine; Diabetes Mellitus; Female; Ga

2016
Major Increase in Microbiota-Dependent Proatherogenic Metabolite TMAO One Year After Bariatric Surgery.
    Metabolic syndrome and related disorders, 2016, Volume: 14, Issue:4

    Topics: Adult; Atherosclerosis; Bariatric Surgery; Betaine; Body Mass Index; Cardiovascular Diseases; Carnit

2016
Advanced chronic kidney disease populations have elevated trimethylamine N-oxide levels associated with increased cardiovascular events.
    Kidney international, 2016, Volume: 89, Issue:5

    Topics: Aged; Aged, 80 and over; Biomarkers; Canada; Cardiovascular Diseases; Disease-Free Survival; Female;

2016
Effect of Trimethylamine N-Oxide on Interfacial Electrostatics at Phospholipid Monolayer-Water Interfaces and Its Relevance to Cardiovascular Disease.
    The journal of physical chemistry letters, 2016, 05-05, Volume: 7, Issue:9

    Topics: Cardiovascular Diseases; Cell Membrane; Endothelial Cells; Humans; Methylamines; Phospholipids; Stat

2016
[Distribution characteristics of trimethylamine N-oxide and its association with gut microbiota].
    Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2016, Volume: 36, Issue:4

    Topics: Adult; Atherosclerosis; Bacteria; Biomarkers; Cardiovascular Diseases; Chromatography, Liquid; Gastr

2016
Diabetes is Associated with Higher Trimethylamine N-oxide Plasma Levels.
    Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association, 2016, Volume: 124, Issue:4

    Topics: Age Factors; Aged; Animals; Body Mass Index; Cardiovascular Diseases; Carnitine; Diabetes Mellitus;

2016
Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men.
    The American journal of clinical nutrition, 2016, Volume: 104, Issue:1

    Topics: Adult; Cardiovascular Diseases; Cohort Studies; Diabetes Complications; Diet; Female; Humans; Male;

2016
The influence of a chronic L-carnitine administration on the plasma metabolome of male Fischer 344 rats.
    Molecular nutrition & food research, 2017, Volume: 61, Issue:5

    Topics: Animals; Carcinogens; Cardiovascular Diseases; Carnitine; Dietary Supplements; Dose-Response Relatio

2017
The gut-blood barrier permeability - A new marker in cardiovascular and metabolic diseases?
    Medical hypotheses, 2017, Volume: 98

    Topics: Biomarkers; Cardiovascular Diseases; Cardiovascular System; Gastrointestinal Microbiome; Homeostasis

2017
Blood Trimethylamine-N-Oxide Originates from Microbiota Mediated Breakdown of Phosphatidylcholine and Absorption from Small Intestine.
    PloS one, 2017, Volume: 12, Issue:1

    Topics: Aged; Cardiovascular Diseases; Gas Chromatography-Mass Spectrometry; Humans; Intestine, Small; Male;

2017
Cardiovascular disease: the diet-microbe morbid union.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Choline; Diet; Dietary Fats;

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease.
    Nature, 2011, Apr-07, Volume: 472, Issue:7341

    Topics: Animals; Atherosclerosis; Betaine; Biomarkers; Cardiovascular Diseases; Cholesterol, HDL; Choline; D

2011
Pathology: At the heart of the problem.
    Nature, 2013, Jan-31, Volume: 493, Issue:7434

    Topics: Animals; Bacteria; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diet; Gastrointestin

2013