trimethyloxamine has been researched along with Alzheimer Disease in 12 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alzheimer's disease is associated with multiple risk factors and is the most common type of dementia." | 2.82 | The role of trimethylamine-N-Oxide in the development of Alzheimer's disease. ( Buawangpong, N; Chattipakorn, N; Chattipakorn, SC; Pinyopornpanish, K; Siri-Angkul, N, 2022) |
| "Alzheimer's disease is a severe brain illness that causes vast numbers of nerve cells in the brain to die, driven by the production and deposition of amyloid beta (Aβ) peptides." | 1.48 | Synergistic approaches unraveling regulation and aggregation of intrinsically disordered β-amyloids implicated in Alzheimer's disease. ( Grover, A; Kumari, A; Rajput, R; Shrivastava, N; Somvanshi, P, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 5 (41.67) | 2.80 |
| Authors | Studies |
|---|---|
| Buawangpong, N | 1 |
| Pinyopornpanish, K | 1 |
| Siri-Angkul, N | 1 |
| Chattipakorn, N | 1 |
| Chattipakorn, SC | 1 |
| Zarbock, KR | 1 |
| Han, JH | 1 |
| Singh, AP | 1 |
| Thomas, SP | 1 |
| Bendlin, BB | 2 |
| Denu, JM | 1 |
| Yu, JJ | 1 |
| Rey, FE | 2 |
| Ulland, TK | 1 |
| Arsiccio, A | 1 |
| Liu, X | 1 |
| Ganguly, P | 1 |
| Buratto, SK | 1 |
| Bowers, MT | 1 |
| Shea, JE | 1 |
| Gao, Q | 1 |
| Wang, Y | 1 |
| Wang, X | 1 |
| Fu, S | 1 |
| Zhang, X | 2 |
| Wang, RT | 1 |
| Zhuang, Z | 1 |
| Gao, M | 1 |
| Yang, R | 1 |
| Liu, Z | 1 |
| Cao, W | 1 |
| Huang, T | 1 |
| Arrona Cardoza, P | 1 |
| Spillane, MB | 1 |
| Morales Marroquin, E | 1 |
| Del Rio, D | 1 |
| Zimetti, F | 1 |
| Caffarra, P | 1 |
| Tassotti, M | 1 |
| Bernini, F | 1 |
| Brighenti, F | 1 |
| Zini, A | 1 |
| Zanotti, I | 1 |
| Kumari, A | 1 |
| Rajput, R | 1 |
| Shrivastava, N | 1 |
| Somvanshi, P | 1 |
| Grover, A | 1 |
| Vogt, NM | 1 |
| Romano, KA | 1 |
| Darst, BF | 1 |
| Engelman, CD | 1 |
| Johnson, SC | 1 |
| Carlsson, CM | 1 |
| Asthana, S | 1 |
| Blennow, K | 1 |
| Zetterberg, H | 1 |
| Xu, R | 1 |
| Wang, Q | 1 |
| LeVine, H | 1 |
| Yang, DS | 1 |
| Yip, CM | 1 |
| Huang, TH | 1 |
| Chakrabartty, A | 1 |
| Fraser, PE | 1 |
2 reviews available for trimethyloxamine and Alzheimer Disease
| Article | Year |
|---|---|
The role of trimethylamine-N-Oxide in the development of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Choline; Methylamines; Oxides | 2022 |
Alzheimer's disease and gut microbiota: does trimethylamine N-oxide (TMAO) play a role?
Topics: Alzheimer Disease; Gastrointestinal Microbiome; Humans; Methylamines; Neurodegenerative Diseases | 2022 |
10 other studies available for trimethyloxamine and Alzheimer Disease
| Article | Year |
|---|---|
Trimethylamine N-Oxide Reduces Neurite Density and Plaque Intensity in a Murine Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Disease Models, Animal; Mice; Mice, Transgenic; N | 2022 |
Effect of Cosolutes on the Aggregation of a Tau Fragment: A Combined Experimental and Simulation Approach.
Topics: 2-Hydroxypropyl-beta-cyclodextrin; Alzheimer Disease; Humans; Molecular Dynamics Simulation; tau Pro | 2023 |
Decreased levels of circulating trimethylamine N-oxide alleviate cognitive and pathological deterioration in transgenic mice: a potential therapeutic approach for Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Behavior, Animal; Cognition; Disease Models, Anim | 2019 |
Causal relationships between gut metabolites and Alzheimer's disease: a bidirectional Mendelian randomization study.
Topics: Alzheimer Disease; Betaine; Carnitine; Choline; Female; Gastrointestinal Microbiome; Genetic Predisp | 2021 |
The Gut Microbial Metabolite Trimethylamine-N-Oxide Is Present in Human Cerebrospinal Fluid.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bacteria; Chromatography, Liquid; Dementia; Female; Gast | 2017 |
Synergistic approaches unraveling regulation and aggregation of intrinsically disordered β-amyloids implicated in Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Humans; Intrinsically Disordered Proteins; Methylamines; P | 2018 |
The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cognitive Dysfunction; Female; Gastroint | 2018 |
Towards understanding brain-gut-microbiome connections in Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Computational Biology; Gastrointestinal Microbiome; Genome-Wide Associatio | 2016 |
Y10W beta(1-40) fluorescence reflects epitope exposure in conformers of Alzheimer's beta-peptide.
Topics: Alzheimer Disease; Amino Acid Sequence; Amino Acid Substitution; Amyloid beta-Peptides; Antibodies, | 2003 |
Manipulating the amyloid-beta aggregation pathway with chemical chaperones.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Circular Dichroism; Fluorescent Dyes; Glycerol; Humans; Me | 1999 |