trimethyloxamine has been researched along with Aging in 10 studies
trimethyloxamine: used in manufacture of quaternary ammonium cpds; insect attractant; warming agent for gas; oxidant; structure
trimethylamine N-oxide : A tertiary amine oxide resulting from the oxidation of the amino group of trimethylamine.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Gut dysbiosis increases with aging, and it has been associated with the impairment of gut barrier function leading to the leakage of harmful metabolites such as trimethylamine (TMA)." | 9.41 | The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease. ( Al-Arawe, N; El Hage, R; Hinterseher, I, 2023) |
| " Gut dysbiosis increases with aging, and it has been associated with the impairment of gut barrier function leading to the leakage of harmful metabolites such as trimethylamine (TMA)." | 5.41 | The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease. ( Al-Arawe, N; El Hage, R; Hinterseher, I, 2023) |
| "Dysbiosis is associated with intestinal inflammation and reduced integrity of the gut barrier, which in turn increases circulating levels of bacterial structural components and microbial metabolites that may facilitate the development of CVD." | 2.58 | The gut microbiota as a novel regulator of cardiovascular function and disease. ( Battson, ML; Gentile, CL; Lee, DM; Weir, TL, 2018) |
| "Vascular dysfunction: develops progressively with ageing; increases the risk of cardiovascular diseases (CVD); and is characterized by endothelial dysfunction and arterial stiffening, which are primarily mediated by superoxide-driven oxidative stress and consequently reduced nitric oxide (NO) bioavailability and arterial structural changes." | 1.72 | Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. ( Brunt, VE; Casso, AG; Clayton, ZS; Davy, KP; Gioscia-Ryan, RA; Greenberg, NT; Hutton, DA; Neilson, AP; Seals, DR; VanDongen, NS; Ziemba, BP, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 7 (70.00) | 2.80 |
| Authors | Studies |
|---|---|
| Casso, AG | 3 |
| VanDongen, NS | 3 |
| Gioscia-Ryan, RA | 5 |
| Clayton, ZS | 2 |
| Greenberg, NT | 1 |
| Ziemba, BP | 3 |
| Hutton, DA | 2 |
| Neilson, AP | 5 |
| Davy, KP | 4 |
| Seals, DR | 5 |
| Brunt, VE | 5 |
| Zhang, L | 1 |
| Yu, F | 1 |
| Xia, J | 1 |
| El Hage, R | 1 |
| Al-Arawe, N | 1 |
| Hinterseher, I | 1 |
| Sapinsley, ZJ | 3 |
| Richey, JJ | 3 |
| Zigler, MC | 3 |
| LaRocca, TJ | 1 |
| Bazzoni, AE | 2 |
| Miyamoto-Ditmon, J | 1 |
| Link, CD | 1 |
| Craven, H | 1 |
| McGuinness, D | 1 |
| Buchanan, S | 1 |
| Galbraith, N | 1 |
| McGuinness, DH | 1 |
| Jones, B | 1 |
| Combet, E | 1 |
| Mafra, D | 1 |
| Bergman, P | 1 |
| Ellaway, A | 1 |
| Stenvinkel, P | 1 |
| Ijaz, UZ | 1 |
| Shiels, PG | 1 |
| Ke, Y | 1 |
| Li, D | 1 |
| Zhao, M | 1 |
| Liu, C | 1 |
| Liu, J | 1 |
| Zeng, A | 1 |
| Shi, X | 1 |
| Cheng, S | 1 |
| Pan, B | 1 |
| Zheng, L | 1 |
| Hong, H | 1 |
| Battson, ML | 2 |
| Lee, DM | 1 |
| Weir, TL | 1 |
| Gentile, CL | 1 |
| Cuevas, LM | 1 |
| Gonzalez, A | 1 |
| Vázquez-Baeza, Y | 1 |
| Smithson, AT | 1 |
| Gilley, AD | 1 |
| Ackermann, G | 1 |
| Weir, T | 1 |
| Knight, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Impact of Lp299v on Vascular Aging in Healthy Adults[NCT05296395] | 20 participants (Anticipated) | Interventional | 2023-02-01 | Recruiting | |||
| Effects of a Whole Food Based Nutritional Formulation on Trimethylamine N-oxide and Cardiometabolic Endpoints in Healthy Adults.[NCT05795946] | 45 participants (Anticipated) | Interventional | 2023-04-15 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for trimethyloxamine and Aging
| Article | Year |
|---|---|
Trimethylamine N-oxide: role in cell senescence and age-related diseases.
Topics: Aging; Animals; Cellular Senescence; Methylamines; Mice; Oxidative Stress | 2023 |
The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease.
Topics: Aged; Aging; Animals; Atherosclerosis; Dysbiosis; Gastrointestinal Microbiome; Humans; Methylamines | 2023 |
The gut microbiota as a novel regulator of cardiovascular function and disease.
Topics: Aging; Animals; Anti-Bacterial Agents; Atherosclerosis; Bile Acids and Salts; Cardiovascular Disease | 2018 |
7 other studies available for trimethyloxamine and Aging
| Article | Year |
|---|---|
Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice.
Topics: Aging; Animals; Butanols; Cardiovascular Diseases; Drinking Water; Endothelium, Vascular; Humans; Mi | 2022 |
Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans.
Topics: Acetylcholine; Adolescent; Adult; Aged; Aging; Animals; Antioxidants; Ascorbic Acid; Brachial Artery | 2020 |
The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging.
Topics: Aging; Animals; Cognition; Gastrointestinal Microbiome; Methylamines; Mice | 2021 |
Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.
Topics: Adolescent; Adult; Age Factors; Aged; Aging; Animals; Aorta; Blood Pressure; Female; Humans; Male; M | 2021 |
Socioeconomic position links circulatory microbiota differences with biological age.
Topics: Adult; Aged; Aging; Bacteria; Betaine; Female; Humans; Life Style; Male; Methylamines; Middle Aged; | 2021 |
Gut flora-dependent metabolite Trimethylamine-N-oxide accelerates endothelial cell senescence and vascular aging through oxidative stress.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Animals; beta-Galactosidase; Blood Proteins; Cell | 2018 |
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Topics: Aging; Animals; Anti-Bacterial Agents; Carotid Arteries; Endothelium, Vascular; Gastrointestinal Mic | 2019 |
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Topics: Aging; Animals; Anti-Bacterial Agents; Carotid Arteries; Endothelium, Vascular; Gastrointestinal Mic | 2019 |
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Topics: Aging; Animals; Anti-Bacterial Agents; Carotid Arteries; Endothelium, Vascular; Gastrointestinal Mic | 2019 |
Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice.
Topics: Aging; Animals; Anti-Bacterial Agents; Carotid Arteries; Endothelium, Vascular; Gastrointestinal Mic | 2019 |