Page last updated: 2024-10-20

trimethylamine and Syndrome

trimethylamine has been researched along with Syndrome in 24 studies

Syndrome: A characteristic symptom complex.

Research Excerpts

ExcerptRelevanceReference
"The fish odour syndrome was diagnosed in 11 subjects: the percentage of total trimethylamine excreted in their urine samples that was oxidised to trimethylamine N-oxide was < 55% under normal dietary conditions and < 25% after oral challenge with trimethylamine (in normal subjects > 80% of trimethylamine was N-oxidised)."5.07The fish odour syndrome: biochemical, familial, and clinical aspects. ( Ayesh, R; Mitchell, SC; Smith, RL; Zhang, A, 1993)
" The aliphatic tertiary amine, trimethylamine, is such a volatile compound that is generated to excess in patients with a metabolic disorder known as trimethylaminuria (fish-odour syndrome)."4.82Trimethylaminuria (fish-odour syndrome) and oral malodour. ( Mitchell, SC, 2005)
"Trimethylaminuria or fish odor syndrome is a metabolic disorder characterized by a failure in the oxidation route from trimethylamine (TMA) to trimethylamineN-oxide (TMA-O)."3.72[Primary trimethylaminuria or fish odor syndrome. A novel mutation in the first documented case in Spain]. ( Bandrés Echeverri, T; Berrade Zubiri, S; Engelke, U; Gil-Setas, A; Mazón Ramos, A; Wevers, R; Zschocke, J, 2003)
"Fish odour syndrome (trimethylaminuria) is a metabolic syndrome caused by abnormal excretion of trimethylamine in the breath, urine, sweat, saliva and vaginal secretions."3.70Fish odor syndrome. ( Rehman, HU, 1999)
"We have previously shown that primary trimethylaminuria, or fish-odour syndrome, is caused by an inherited defect in the flavin-containing monooxygenase 3 (FMO3) catalysed N-oxidation of the dietary-derived malodorous amine, trimethylamine (TMA)."3.70A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy. ( Chalmers, RA; Dolphin, CT; Holmes, HC; Iles, RA; Janmohamed, A; Michelakakis, H; Murphy, HC; Phillips, IR; Shephard, EA, 2000)
"An oral trimethylamine challenge test has been used to confirm the heterozygous status of patients with 'fish-odour syndrome'."3.69Fish odour syndrome: verification of carrier detection test. ( Mitchell, S; Smith, R; Zhang, AQ, 1995)
" Beginning with a single propositus, who had been previously diagnosed at the age of 10 as suffering from trimethylaminuria (fish-odour syndrome), both her parents and two sisters were investigated biochemically with respect to their ability to N-oxidize trimethylamine (TMA), both when derived from the diet and when administered exogenously."3.67Trimethylaminuria ('fish-odour syndrome'): a study of an affected family. ( Al-Waiz, M; Ayesh, R; Idle, JR; Mitchell, SC; Smith, RL, 1988)

Research

Studies (24)

TimeframeStudies, this research(%)All Research%
pre-19905 (20.83)18.7374
1990's11 (45.83)18.2507
2000's8 (33.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Almenar Bonet, MV1
Llinares Tello, F1
Torregrosa Quesada, ME1
Segrelles Lloret, M1
Mountain, H1
Brisbane, JM1
Hooper, AJ1
Burnett, JR1
Goldblatt, J1
Mazón Ramos, A1
Gil-Setas, A1
Berrade Zubiri, S1
Bandrés Echeverri, T1
Wevers, R1
Engelke, U1
Zschocke, J2
Mitchell, SC6
Arseculeratne, G1
Wong, AK1
Goudie, DR1
Ferguson, J1
Werner, D1
Fenwick, GR1
Butler, EJ1
Brewster, MA1
Shelley, ED1
Shelley, WB1
Ruocco, V1
Florio, M1
Walker, V1
Ayesh, R3
Zhang, A2
Smith, RL5
Chen, H1
Aiello, F1
Zhang, AQ1
Mitchell, S1
Smith, R1
Dolphin, CT2
Janmohamed, A2
Shephard, EA2
Phillips, IR2
Eugène, M1
Kohlmueller, D1
Quak, E1
Meissner, T1
Hoffmann, GF1
Mayatepek, E1
Rehman, HU1
Kashyap, AS1
Kashyap, S1
Murphy, HC1
Holmes, HC1
Michelakakis, H1
Chalmers, RA1
Iles, RA1
Al-Waiz, M2
Idle, JR2
Rothschild, JG1
Hansen, RC1

Reviews

3 reviews available for trimethylamine and Syndrome

ArticleYear
Trimethylaminuria (fish-odour syndrome) and oral malodour.
    Oral diseases, 2005, Volume: 11 Suppl 1

    Topics: Amino Acid Metabolism, Inborn Errors; Fish Products; Halitosis; Humans; Liver Diseases; Methylamines

2005
Trimethylaminuria in a girl with Prader-Willi syndrome and del(15)(q11q13).
    American journal of medical genetics, 1993, Feb-01, Volume: 45, Issue:3

    Topics: Animals; Child; Choline; Chromosome Deletion; Chromosomes, Human, Pair 15; Diet; Female; Fishes; Hum

1993
The fish-odor syndrome.
    Perspectives in biology and medicine, 1996,Summer, Volume: 39, Issue:4

    Topics: Diet; Halitosis; Humans; Metabolism, Inborn Errors; Methylamines; Odorants; Sweat; Syndrome

1996

Trials

1 trial available for trimethylamine and Syndrome

ArticleYear
The fish odour syndrome: biochemical, familial, and clinical aspects.
    BMJ (Clinical research ed.), 1993, Sep-11, Volume: 307, Issue:6905

    Topics: Adolescent; Adult; Animals; Female; Fishes; Humans; Infant; Male; Mental Disorders; Metabolism, Inbo

1993

Other Studies

20 other studies available for trimethylamine and Syndrome

ArticleYear
[Trimethylaminuria (fish-odor syndrome): a case report].
    Medicina clinica, 2008, Sep-20, Volume: 131, Issue:9

    Topics: Humans; Male; Metabolic Diseases; Methylamines; Middle Aged; Odorants; Syndrome

2008
Trimethylaminuria (fish malodour syndrome): a "benign" genetic condition with major psychosocial sequelae.
    The Medical journal of Australia, 2008, Oct-20, Volume: 189, Issue:8

    Topics: Adult; Animals; Female; Fishes; Humans; Methylamines; Mutation; Odorants; Oxygenases; Syndrome

2008
[Primary trimethylaminuria or fish odor syndrome. A novel mutation in the first documented case in Spain].
    Medicina clinica, 2003, Feb-22, Volume: 120, Issue:6

    Topics: Child, Preschool; Female; Humans; Metabolic Diseases; Methylamines; Mutation; Spain; Syndrome

2003
Trimethylaminuria (fish-odor syndrome): a case report.
    Archives of dermatology, 2007, Volume: 143, Issue:1

    Topics: Adult; Antioxidants; Consanguinity; Humans; Male; Metabolism, Inborn Errors; Methylamines; Mutation;

2007
[Trimethylaminuria (fish-odour syndrome)--hints for a new therapeutic option with desmopressin].
    Aktuelle Urologie, 2007, Volume: 38, Issue:5

    Topics: Antidiuretic Agents; Child, Preschool; Deamino Arginine Vasopressin; Fish Products; Humans; Male; Me

2007
Are brassica vegetables aggravating factors in trimethylaminuria (fish odour syndrome)?
    Lancet (London, England), 1983, Oct-15, Volume: 2, Issue:8355

    Topics: Animals; Brassica; Humans; Methylamines; Odorants; Syndrome

1983
The fish odor syndrome. Trimethylaminuria.
    JAMA, 1984, Jan-13, Volume: 251, Issue:2

    Topics: Abnormalities, Multiple; Adult; Humans; Liver; Male; Metabolic Diseases; Methylamines; Odorants; Syn

1984
Fish-odor syndrome: an olfactory diagnosis.
    International journal of dermatology, 1995, Volume: 34, Issue:2

    Topics: Diet; Humans; Metabolism, Inborn Errors; Methylamines; Odorants; Sweat; Syndrome

1995
The fish odour syndrome.
    BMJ (Clinical research ed.), 1993, Sep-11, Volume: 307, Issue:6905

    Topics: Humans; Metabolism, Inborn Errors; Methylamines; Odorants; Oxidation-Reduction; Syndrome

1993
Fish-odour syndrome and impaired N-oxidation.
    Biochemical Society transactions, 1996, Volume: 24, Issue:1

    Topics: Diet; Female; Genetic Carrier Screening; Homozygote; Humans; Male; Metal Metabolism, Inborn Errors;

1996
Fish odour syndrome: verification of carrier detection test.
    Journal of inherited metabolic disease, 1995, Volume: 18, Issue:6

    Topics: Adult; Female; Genetic Carrier Screening; Humans; Male; Metabolism, Inborn Errors; Methylamines; Odo

1995
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome.
    Nature genetics, 1997, Volume: 17, Issue:4

    Topics: Amino Acid Sequence; Animals; Base Sequence; Humans; Metabolism, Inborn Errors; Methylamines; Molecu

1997
[Diagnosis of "fish odor syndrome" by urine nuclear magnetic resonance proton spectrometry].
    Annales de dermatologie et de venereologie, 1998, Volume: 125, Issue:3

    Topics: Genetic Carrier Screening; Genetic Diseases, Inborn; Humans; Magnetic Resonance Spectroscopy; Methyl

1998
Mild trimethylaminuria caused by common variants in FMO3 gene.
    Lancet (London, England), 1999, Sep-04, Volume: 354, Issue:9181

    Topics: Adult; Child; Genes, Recessive; Genetic Variation; Humans; Metabolism, Inborn Errors; Methylamines;

1999
Fish odor syndrome.
    Postgraduate medical journal, 1999, Volume: 75, Issue:886

    Topics: Enterobacteriaceae; Humans; Metabolic Diseases; Methylamines; Odorants; Oxidation-Reduction; Syndrom

1999
Fish odour syndrome.
    Postgraduate medical journal, 2000, Volume: 76, Issue:895

    Topics: Alleles; Humans; Methylamines; Odorants; Oxygenases; Phenotype; Polymorphism, Genetic; Syndrome

2000
A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy.
    Pharmacogenetics, 2000, Volume: 10, Issue:5

    Topics: Adult; Alleles; Amino Acid Sequence; Amino Acid Substitution; Base Sequence; Child, Preschool; Femal

2000
Trimethylaminuria (fish-odour syndrome): an inborn error of oxidative metabolism.
    Lancet (London, England), 1987, Mar-14, Volume: 1, Issue:8533

    Topics: Animals; Child; Female; Fishes; Humans; Metabolism, Inborn Errors; Methylamines; Odorants; Oxidation

1987
Trimethylaminuria ('fish-odour syndrome'): a study of an affected family.
    Clinical science (London, England : 1979), 1988, Volume: 74, Issue:3

    Topics: Adult; Female; Humans; Male; Metabolism, Inborn Errors; Methylamines; Syndrome

1988
Fish odor syndrome: trimethylaminuria with milk as chief dietary factor.
    Pediatric dermatology, 1985, Volume: 3, Issue:1

    Topics: Animals; Cattle; Child; Choline; Humans; Infant; Liver; Male; Methylamines; Milk; Syndrome

1985