trimethylamine has been researched along with Atherogenesis in 42 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| " Gut dysbiosis increases with aging, and it has been associated with the impairment of gut barrier function leading to the leakage of harmful metabolites such as trimethylamine (TMA)." | 9.41 | The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease. ( Al-Arawe, N; El Hage, R; Hinterseher, I, 2023) |
| " Among the well-known con¬tributors to atherosclerosis are less common ones, such as trimethylamine oxide (TMAO)." | 8.31 | TRIMETHYLAMINE OXIDE - FACTOR IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND A POTENTIAL TARGET FOR DIETARY AND PHARMACOLOGICAL INTERVENTIONS. ( Lazar, M; Olma, A; Streb, W, 2023) |
| "Recent evidence suggests that trimethylamine-N-oxide (TMAO), a metabolite of L-carnitine and choline, is linked to atherosclerosis and cardiovascular diseases." | 8.31 | Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults. ( Abe, T; Bhuiya, J; Isomura, M; Kobayashi, H; Nabika, T; Nagai, A; Notsu, Y; Okazaki, R; Sheikh, AM; Shibly, AZ; Yamaguchi, K; Yamasaki, M; Yano, S, 2023) |
| "Microbial trimethylamine (TMA)-lyase activity promotes the development of atherosclerosis by generating of TMA, the precursor of TMA N-oxide (TMAO)." | 8.12 | Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis. ( Alolga, RN; Cai, YY; Gao, X; Huang, FQ; Lao, X; Li, J; Liu, B; Lu, Y; Qi, LW; Shang, J; Wang, Y; Yin, K; Zhou, X, 2022) |
| "Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation." | 8.12 | Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. ( Hong, Y; Ji, N; Luo, X; Ma, W; Nie, Z; Shan, J; Xue, J; Zhang, T; Zhang, Y; Zhou, S; Zhu, W, 2022) |
| "Studies have shown that cadmium (Cd) exposure primarily occurs through diet, and Cd ingestion is a risk factor for atherosclerosis (AS)." | 8.12 | Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota. ( Chen, M; Ou, C; Zhang, J, 2022) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 8.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| "Recently, trimethylamine-N-oxide (TMAO) has been identified as a novel and independent risk factor for promoting atherosclerosis (AS) partially through inhibiting hepatic bile acid (BA) synthesis." | 7.83 | Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota. ( Chen, ML; Mi, MT; Ran, L; Yang, J; Yi, L; Zhang, QY; Zhang, Y; Zhou, X; Zhu, JD, 2016) |
| "Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with cardiovascular risks in clinical studies." | 7.81 | Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. ( Buffa, JA; Culley, MK; DiDonato, AJ; DiDonato, JA; Fu, X; Gu, X; Hazen, JE; Hazen, SL; Huang, Y; Krajcik, D; Levison, BS; Lusis, AJ; Org, E; Roberts, AB; Wang, Z; Zamanian-Daryoush, M; Zhu, W, 2015) |
| "Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis." | 7.79 | Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. ( Allayee, H; Bennett, BJ; Crooke, R; de Aguiar Vallim, TQ; Edwards, PA; Graham, M; Gregory, J; Hazen, SL; Lee, R; Lusis, AJ; Meng, Y; Shih, DM; Wang, Z, 2013) |
| "Atherosclerosis is a chronic inflammatory disease of the arterial wall involving inflammation, redox imbalance, and impaired cholesterol transport." | 5.72 | Chronic oral trimethylamine-N-oxide administration induces experimental incipient atherosclerosis in non-genetically modified mice. ( Ancuta, B; Cismaru, G; Decea, N; Filip, GA; Florea, CM; Moldovan, R; Rosu, R; Toma, V; Vlase, L, 2022) |
| " Gut dysbiosis increases with aging, and it has been associated with the impairment of gut barrier function leading to the leakage of harmful metabolites such as trimethylamine (TMA)." | 5.41 | The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease. ( Al-Arawe, N; El Hage, R; Hinterseher, I, 2023) |
| "l-Carnitine, an abundant nutrient in red meat, accelerates atherosclerosis in mice via gut microbiota-dependent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway involving an atherogenic intermediate, γ-butyrobetaine (γBB)." | 5.30 | l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans. ( Bartlett, D; Cody, DB; Copeland, MF; Culley, MK; Dai, HJ; DiDonato, JA; Fu, X; Garcia-Garcia, JC; Gu, X; Hazen, SL; Kirsop, J; Koeth, RA; Lam-Galvez, BR; Levison, BS; Li, L; Li, XS; Tang, WHW; Wang, Z; Wu, Y, 2019) |
| " To demonstrate the potential for integrating big data into a functional microbiology workflow, we review literature on trimethylamine (TMA), a microbiota-generated metabolite linked to atherosclerosis development." | 4.91 | Microbiology Meets Big Data: The Case of Gut Microbiota-Derived Trimethylamine. ( Falony, G; Raes, J; Vieira-Silva, S, 2015) |
| " Articles were selected using the following search terms: "Intestinal microbiota", "trimethylamine N-oxide (TMAO)", "trimethylamine (TMA)", "cardiovascular", and "atherosclerosis"." | 4.91 | Intestinal Microbiota Metabolism and Atherosclerosis. ( Liu, TX; Niu, HT; Zhang, SY, 2015) |
| "Recent evidence suggests that trimethylamine-N-oxide (TMAO), a metabolite of L-carnitine and choline, is linked to atherosclerosis and cardiovascular diseases." | 4.31 | Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults. ( Abe, T; Bhuiya, J; Isomura, M; Kobayashi, H; Nabika, T; Nagai, A; Notsu, Y; Okazaki, R; Sheikh, AM; Shibly, AZ; Yamaguchi, K; Yamasaki, M; Yano, S, 2023) |
| " Among the well-known con¬tributors to atherosclerosis are less common ones, such as trimethylamine oxide (TMAO)." | 4.31 | TRIMETHYLAMINE OXIDE - FACTOR IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND A POTENTIAL TARGET FOR DIETARY AND PHARMACOLOGICAL INTERVENTIONS. ( Lazar, M; Olma, A; Streb, W, 2023) |
| "Microbial trimethylamine (TMA)-lyase activity promotes the development of atherosclerosis by generating of TMA, the precursor of TMA N-oxide (TMAO)." | 4.12 | Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis. ( Alolga, RN; Cai, YY; Gao, X; Huang, FQ; Lao, X; Li, J; Liu, B; Lu, Y; Qi, LW; Shang, J; Wang, Y; Yin, K; Zhou, X, 2022) |
| "Trimethylamine-N-oxide (TMAO), a gut-microbiota-dependent metabolite after ingesting dietary choline, has been identified as a novel risk factor for atherosclerosis through inducing vascular inflammation." | 4.12 | Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. ( Hong, Y; Ji, N; Luo, X; Ma, W; Nie, Z; Shan, J; Xue, J; Zhang, T; Zhang, Y; Zhou, S; Zhu, W, 2022) |
| "Studies have shown that cadmium (Cd) exposure primarily occurs through diet, and Cd ingestion is a risk factor for atherosclerosis (AS)." | 4.12 | Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota. ( Chen, M; Ou, C; Zhang, J, 2022) |
| "Trimethylamine-N-oxide (TMAO), a derivative from the gut microbiota metabolite trimethylamine (TMA), has been identified to be an independent risk factor for promoting atherosclerosis." | 4.02 | Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome. ( Du, Y; Hong, B; Jiang, J; Jiang, Z; Li, X; Su, C; Wang, L; Yang, M; Yang, Y; Zhang, J; Zhang, X; Zhang, Y, 2021) |
| " Trimethylamine-N-oxide (TMAO) and trimethylamine (TMA) are gut microbiota-derived metabolites, and both are known uraemic toxins that are implicated in CKD, atherosclerosis, colorectal cancer and cardiovascular risk." | 4.02 | Rapid Detection of Gut Microbial Metabolite Trimethylamine N-Oxide for Chronic Kidney Disease Prevention. ( Chang, YC; Chu, YH; Tain, YL; Wang, CC; Wang, CH; Yang, HW, 2021) |
| " Furthermore, unlike chronic dietary choline, TML supplementation in mice failed to elevate plasma TMAO or heighten thrombosis potential in vivo." | 3.88 | Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk. ( Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y, 2018) |
| "Recently, trimethylamine-N-oxide (TMAO) has been identified as a novel and independent risk factor for promoting atherosclerosis (AS) partially through inhibiting hepatic bile acid (BA) synthesis." | 3.83 | Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota. ( Chen, ML; Mi, MT; Ran, L; Yang, J; Yi, L; Zhang, QY; Zhang, Y; Zhou, X; Zhu, JD, 2016) |
| "We performed silencing and overexpression studies of flavin containing monooxygenase (FMO) 3 in hyperlipidemic mouse models to examine its effects on trimethylamine N-oxide (TMAO) levels and atherosclerosis." | 3.81 | Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis. ( Bennett, BJ; Brown, JM; Charugundla, S; Che, N; Graham, M; Hazen, SL; Lee, R; Lusis, AJ; Meng, Y; Pan, C; Qi, H; Shih, DM; Vallim, T; Wang, Z; Wu, J, 2015) |
| " Here we test the hypothesis that gut microbial transplantation can transmit choline diet-induced TMAO production and atherosclerosis susceptibility." | 3.81 | Transmission of atherosclerosis susceptibility with gut microbial transplantation. ( Bennett, BJ; Buffa, JA; DiDonato, JA; Gregory, JC; Hazen, SL; Levison, BS; Li, L; Lusis, AJ; Org, E; Wagner, MA; Wang, Z; Zhu, W, 2015) |
| "Trimethylamine (TMA) N-oxide (TMAO), a gut-microbiota-dependent metabolite, both enhances atherosclerosis in animal models and is associated with cardiovascular risks in clinical studies." | 3.81 | Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis. ( Buffa, JA; Culley, MK; DiDonato, AJ; DiDonato, JA; Fu, X; Gu, X; Hazen, JE; Hazen, SL; Huang, Y; Krajcik, D; Levison, BS; Lusis, AJ; Org, E; Roberts, AB; Wang, Z; Zamanian-Daryoush, M; Zhu, W, 2015) |
| "Circulating trimethylamine-N-oxide (TMAO) levels are strongly associated with atherosclerosis." | 3.79 | Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. ( Allayee, H; Bennett, BJ; Crooke, R; de Aguiar Vallim, TQ; Edwards, PA; Graham, M; Gregory, J; Hazen, SL; Lee, R; Lusis, AJ; Meng, Y; Shih, DM; Wang, Z, 2013) |
| "Atherosclerosis is a major cause of mortalities and morbidities worldwide." | 2.61 | Amelioration of TMAO through probiotics and its potential role in atherosclerosis. ( Din, AU; Gregersen, H; Hassan, A; Wang, G; Yin, T; Zhu, Y, 2019) |
| "Trimethylamine (TMA) is a tertiary amine with a characteristic fishy odour." | 2.53 | The complex metabolism of trimethylamine in humans: endogenous and exogenous sources. ( Bhargava, B; Chhibber-Goel, J; Gaur, A; Parakh, N; Sharma, A; Singhal, V, 2016) |
| "Atherosclerosis is a hallmark of cardiovascular disease, and lifestyle strongly impacts its onset and progression." | 1.72 | TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis. ( Blanco, R; Daimiel, L; Dávalos, A; Díez-Ricote, L; Micó, V; Ordovás, JM; Ruiz-Valderrey, P; Tomé-Carneiro, J, 2022) |
| "Atherosclerosis is a chronic inflammatory disease of the arterial wall involving inflammation, redox imbalance, and impaired cholesterol transport." | 1.72 | Chronic oral trimethylamine-N-oxide administration induces experimental incipient atherosclerosis in non-genetically modified mice. ( Ancuta, B; Cismaru, G; Decea, N; Filip, GA; Florea, CM; Moldovan, R; Rosu, R; Toma, V; Vlase, L, 2022) |
| "Trimethylamine N-oxide was extensively formed in vivo in humanized-liver mice, but not in control mice." | 1.48 | Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice. ( Kusama, T; Miura, T; Mizuno, S; Shimizu, M; Suemizu, H; Uehara, S; Yamazaki, H, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 21 (50.00) | 24.3611 |
| 2020's | 21 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chang, YC | 1 |
| Chu, YH | 1 |
| Wang, CC | 1 |
| Wang, CH | 1 |
| Tain, YL | 1 |
| Yang, HW | 1 |
| Panyod, S | 1 |
| Wu, WK | 1 |
| Chen, PC | 1 |
| Chong, KV | 1 |
| Yang, YT | 1 |
| Chuang, HL | 1 |
| Chen, CC | 1 |
| Chen, RA | 1 |
| Liu, PY | 1 |
| Chung, CH | 1 |
| Huang, HS | 1 |
| Lin, AY | 1 |
| Shen, TD | 1 |
| Yang, KC | 1 |
| Huang, TF | 1 |
| Hsu, CC | 1 |
| Ho, CT | 2 |
| Kao, HL | 1 |
| Orekhov, AN | 1 |
| Wu, MS | 1 |
| Sheen, LY | 1 |
| Cai, YY | 1 |
| Huang, FQ | 1 |
| Lao, X | 1 |
| Lu, Y | 1 |
| Gao, X | 1 |
| Alolga, RN | 1 |
| Yin, K | 1 |
| Zhou, X | 2 |
| Wang, Y | 2 |
| Liu, B | 1 |
| Shang, J | 1 |
| Qi, LW | 1 |
| Li, J | 1 |
| Iglesias-Carres, L | 1 |
| Racine, KC | 1 |
| Neilson, AP | 1 |
| Zhou, S | 1 |
| Xue, J | 1 |
| Shan, J | 1 |
| Hong, Y | 1 |
| Zhu, W | 5 |
| Nie, Z | 1 |
| Zhang, Y | 3 |
| Ji, N | 1 |
| Luo, X | 1 |
| Zhang, T | 1 |
| Ma, W | 1 |
| Zhang, J | 2 |
| Ou, C | 1 |
| Chen, M | 1 |
| Díez-Ricote, L | 1 |
| Ruiz-Valderrey, P | 1 |
| Micó, V | 1 |
| Blanco, R | 1 |
| Tomé-Carneiro, J | 1 |
| Dávalos, A | 1 |
| Ordovás, JM | 1 |
| Daimiel, L | 1 |
| Liu, C | 1 |
| Li, Z | 1 |
| Song, Z | 1 |
| Fan, X | 1 |
| Shao, H | 1 |
| Schönke, M | 1 |
| Boon, MR | 1 |
| Rensen, PCN | 1 |
| Melnychuk, I | 1 |
| Lizogub, VG | 1 |
| El Hage, R | 1 |
| Al-Arawe, N | 1 |
| Hinterseher, I | 1 |
| Bhuiya, J | 1 |
| Notsu, Y | 1 |
| Kobayashi, H | 1 |
| Shibly, AZ | 1 |
| Sheikh, AM | 1 |
| Okazaki, R | 1 |
| Yamaguchi, K | 1 |
| Nagai, A | 1 |
| Nabika, T | 1 |
| Abe, T | 1 |
| Yamasaki, M | 1 |
| Isomura, M | 1 |
| Yano, S | 1 |
| Florea, CM | 1 |
| Rosu, R | 1 |
| Cismaru, G | 1 |
| Moldovan, R | 1 |
| Vlase, L | 1 |
| Toma, V | 1 |
| Decea, N | 1 |
| Ancuta, B | 1 |
| Filip, GA | 1 |
| Olma, A | 1 |
| Streb, W | 1 |
| Lazar, M | 1 |
| Oktaviono, YH | 1 |
| Dyah Lamara, A | 1 |
| Saputra, PBT | 1 |
| Arnindita, JN | 1 |
| Pasahari, D | 1 |
| Saputra, ME | 1 |
| Suasti, NMA | 1 |
| Lemaitre, RN | 1 |
| Jensen, PN | 1 |
| Wang, Z | 8 |
| Fretts, AM | 1 |
| Sitlani, CM | 1 |
| Nemet, I | 2 |
| Sotoodehnia, N | 1 |
| de Oliveira Otto, MC | 1 |
| Budoff, M | 1 |
| Longstreth, WT | 1 |
| Psaty, BM | 1 |
| Siscovick, DS | 1 |
| Hazen, SL | 9 |
| Mozaffarian, D | 1 |
| He, Z | 1 |
| Zhu, H | 1 |
| Liu, J | 1 |
| Kwek, E | 1 |
| Ma, KY | 1 |
| Chen, ZY | 1 |
| Din, AU | 1 |
| Hassan, A | 1 |
| Zhu, Y | 1 |
| Yin, T | 1 |
| Gregersen, H | 1 |
| Wang, G | 1 |
| Bordoni, L | 1 |
| Sawicka, AK | 1 |
| Szarmach, A | 1 |
| Winklewski, PJ | 1 |
| Olek, RA | 1 |
| Gabbianelli, R | 1 |
| Lüscher, TF | 2 |
| Paul, N | 1 |
| Sarkar, R | 1 |
| Sarkar, S | 1 |
| Li, X | 1 |
| Su, C | 1 |
| Jiang, Z | 2 |
| Yang, Y | 1 |
| Yang, M | 1 |
| Zhang, X | 1 |
| Du, Y | 1 |
| Wang, L | 1 |
| Jiang, J | 1 |
| Hong, B | 1 |
| Liu, S | 1 |
| He, F | 1 |
| Zheng, T | 1 |
| Wan, S | 1 |
| Chen, J | 1 |
| Yang, F | 1 |
| Xu, X | 1 |
| Pei, X | 1 |
| He, H | 1 |
| Lian, X | 1 |
| Tang, Z | 1 |
| Palinski, W | 1 |
| Li, XS | 2 |
| Cajka, T | 1 |
| Buffa, JA | 3 |
| Hurd, AG | 1 |
| Gu, X | 3 |
| Skye, SM | 1 |
| Roberts, AB | 2 |
| Wu, Y | 2 |
| Li, L | 3 |
| Shahen, CJ | 1 |
| Wagner, MA | 2 |
| Hartiala, JA | 1 |
| Kerby, RL | 1 |
| Romano, KA | 1 |
| Han, Y | 1 |
| Obeid, S | 1 |
| Allayee, H | 3 |
| Rey, FE | 1 |
| DiDonato, JA | 4 |
| Fiehn, O | 1 |
| Tang, WHW | 2 |
| Shimizu, M | 1 |
| Suemizu, H | 1 |
| Mizuno, S | 1 |
| Kusama, T | 1 |
| Miura, T | 1 |
| Uehara, S | 1 |
| Yamazaki, H | 1 |
| Gautam, A | 1 |
| Paudel, YN | 1 |
| Abidin, S | 1 |
| Bhandari, U | 1 |
| Koeth, RA | 1 |
| Lam-Galvez, BR | 1 |
| Kirsop, J | 1 |
| Levison, BS | 3 |
| Copeland, MF | 1 |
| Bartlett, D | 1 |
| Cody, DB | 1 |
| Dai, HJ | 1 |
| Culley, MK | 2 |
| Fu, X | 2 |
| Garcia-Garcia, JC | 1 |
| Shih, DM | 3 |
| Schugar, RC | 1 |
| Meng, Y | 3 |
| Jia, X | 1 |
| Miikeda, A | 1 |
| Zieger, M | 1 |
| Lee, R | 3 |
| Graham, M | 3 |
| Cantor, RM | 1 |
| Mueller, C | 1 |
| Brown, JM | 2 |
| Lusis, AJ | 5 |
| Chen, Y | 1 |
| Weng, Z | 1 |
| Liu, Q | 1 |
| Shao, W | 1 |
| Guo, W | 1 |
| Chen, C | 1 |
| Jiao, L | 1 |
| Wang, Q | 1 |
| Lu, Q | 1 |
| Sun, H | 1 |
| Gu, A | 1 |
| Hu, H | 1 |
| Chen, PY | 1 |
| Li, S | 1 |
| Koh, YC | 1 |
| Wu, JC | 1 |
| Yang, MJ | 1 |
| Pan, MH | 1 |
| Ussher, JR | 1 |
| Lopaschuk, GD | 1 |
| Arduini, A | 1 |
| Tang, WH | 1 |
| Che, N | 1 |
| Charugundla, S | 1 |
| Qi, H | 1 |
| Wu, J | 1 |
| Pan, C | 1 |
| Vallim, T | 1 |
| Bennett, BJ | 3 |
| Gregory, JC | 1 |
| Org, E | 2 |
| Falony, G | 1 |
| Vieira-Silva, S | 1 |
| Raes, J | 1 |
| Liu, TX | 1 |
| Niu, HT | 1 |
| Zhang, SY | 1 |
| Huang, Y | 1 |
| Zamanian-Daryoush, M | 1 |
| DiDonato, AJ | 1 |
| Hazen, JE | 1 |
| Krajcik, D | 1 |
| Chen, ML | 1 |
| Yi, L | 1 |
| Ran, L | 1 |
| Yang, J | 1 |
| Zhu, JD | 1 |
| Zhang, QY | 1 |
| Mi, MT | 1 |
| Chhibber-Goel, J | 1 |
| Gaur, A | 1 |
| Singhal, V | 1 |
| Parakh, N | 1 |
| Bhargava, B | 1 |
| Sharma, A | 1 |
| Petriello, MC | 1 |
| Hoffman, JB | 1 |
| Sunkara, M | 1 |
| Wahlang, B | 1 |
| Perkins, JT | 1 |
| Morris, AJ | 1 |
| Hennig, B | 1 |
| de Aguiar Vallim, TQ | 1 |
| Gregory, J | 1 |
| Crooke, R | 1 |
| Edwards, PA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effects of Dietary Supplementation Allicor on Patients With Multifocal Atherosclerosis After Peripheral Artery Revascularization Treatment During a Year[NCT05813171] | Phase 4 | 300 participants (Anticipated) | Interventional | 2023-04-20 | Not yet recruiting | ||
| The Effects of Dietary Supplementation Allicor on the Effectiveness of Treatment of Patients After Coronary Arteria Revascularization[NCT05803759] | Phase 4 | 200 participants (Anticipated) | Interventional | 2023-04-10 | Recruiting | ||
| CARNIVAL Study: Gut Flora Dependent Metabolism of Dietary CARNItine and Phosphatidylcholine and cardioVAscuLar Disease[NCT01731236] | Early Phase 1 | 100 participants (Anticipated) | Interventional | 2011-02-11 | Enrolling by invitation | ||
| "Plant-Based Meat vs Animal Red Meat: a Randomized Cross-over Trial"[NCT04510324] | 41 participants (Actual) | Interventional | 2020-11-01 | Completed | |||
| Impact of the Combined Treatment of Curcumin and Resveratrol Liposomed Polyphenols With G04CB02 on the Clinical Improvement of ALS Patients[NCT04654689] | Phase 2 | 90 participants (Actual) | Interventional | 2021-11-20 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
8 reviews available for trimethylamine and Atherogenesis
| Article | Year |
|---|---|
The Role of the Gut Microbiome and Trimethylamine Oxide in Atherosclerosis and Age-Related Disease.
Topics: Aged; Aging; Animals; Atherosclerosis; Dysbiosis; Gastrointestinal Microbiome; Humans; Methylamines | 2023 |
The roles of trimethylamine-N-oxide in atherosclerosis and its potential therapeutic aspect: A literature review.
Topics: Atherosclerosis; Choline; Endothelial Cells; Humans; Lyases; Oxides; Plaque, Atherosclerotic | 2023 |
Amelioration of TMAO through probiotics and its potential role in atherosclerosis.
Topics: Animals; Atherosclerosis; Humans; Metabolomics; Methylamines; Mice; Microbiota; MicroRNAs; Probiotic | 2019 |
Gut microbiota metabolism of L-carnitine and cardiovascular risk.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Diet; Dietary Supplements; Humans; Ins | 2013 |
The contributory role of gut microbiota in cardiovascular disease.
Topics: Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Choline; Diet; Female; Food; Humans; I | 2014 |
Microbiology Meets Big Data: The Case of Gut Microbiota-Derived Trimethylamine.
Topics: Animals; Atherosclerosis; Dysbiosis; Gastrointestinal Microbiome; Humans; Metagenomics; Methylamines | 2015 |
Intestinal Microbiota Metabolism and Atherosclerosis.
Topics: Atherosclerosis; Gastrointestinal Microbiome; Humans; Methylamines | 2015 |
The complex metabolism of trimethylamine in humans: endogenous and exogenous sources.
Topics: Air Pollutants; Animals; Atherosclerosis; Diet; Humans; Metabolism, Inborn Errors; Methylamines; Neo | 2016 |
3 trials available for trimethylamine and Atherogenesis
| Article | Year |
|---|---|
Plasma Trimethylamine-
Topics: Aged; Atherosclerosis; Female; Humans; Ischemic Stroke; Methylamines; Oxides; Prospective Studies; R | 2023 |
A Pilot Study on the Effects of l-Carnitine and Trimethylamine-N-Oxide on Platelet Mitochondrial DNA Methylation and CVD Biomarkers in Aged Women.
Topics: Aged; Atherosclerosis; Biomarkers; Blood Platelets; Cardiovascular System; Carnitine; Dietary Supple | 2020 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
l-Carnitine in omnivorous diets induces an atherogenic gut microbial pathway in humans.
Topics: Animals; Atherosclerosis; Betaine; Carnitine; Clostridiales; Female; Gastrointestinal Microbiome; Hu | 2019 |
31 other studies available for trimethylamine and Atherogenesis
| Article | Year |
|---|---|
Rapid Detection of Gut Microbial Metabolite Trimethylamine N-Oxide for Chronic Kidney Disease Prevention.
Topics: Atherosclerosis; Gastrointestinal Microbiome; Humans; Manganese Compounds; Methylamines; Oxides; Ren | 2021 |
Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.
Topics: Animals; Atherosclerosis; Disulfides; Garlic; Gastrointestinal Microbiome; Humans; Methylamines; Mic | 2022 |
Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.
Topics: Animals; Atherosclerosis; Disulfides; Garlic; Gastrointestinal Microbiome; Humans; Methylamines; Mic | 2022 |
Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.
Topics: Animals; Atherosclerosis; Disulfides; Garlic; Gastrointestinal Microbiome; Humans; Methylamines; Mic | 2022 |
Atherosclerosis amelioration by allicin in raw garlic through gut microbiota and trimethylamine-N-oxide modulation.
Topics: Animals; Atherosclerosis; Disulfides; Garlic; Gastrointestinal Microbiome; Humans; Methylamines; Mic | 2022 |
Integrated metagenomics identifies a crucial role for trimethylamine-producing Lachnoclostridium in promoting atherosclerosis.
Topics: Animals; Atherosclerosis; Choline; Gastrointestinal Microbiome; Humans; Metagenomics; Methylamines; | 2022 |
Phenolic-rich beverages reduce bacterial TMA formation in an
Topics: Atherosclerosis; Bacteria; Beverages; Chlorogenic Acid; Choline; Coffee; Fermentation; Humans; Methy | 2022 |
Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1.
Topics: AMP-Activated Protein Kinases; Animals; Atherosclerosis; Choline; Gastrointestinal Microbiome; Infla | 2022 |
Curcumin attenuates cadmium-induced atherosclerosis by regulating trimethylamine-N-oxide synthesis and macrophage polarization through remodeling the gut microbiota.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cadmium; Curcumin; Gastrointestinal Microbiome; Macroph | 2022 |
TMAO Upregulates Members of the miR-17/92 Cluster and Impacts Targets Associated with Atherosclerosis.
Topics: Animals; Atherosclerosis; Betaine; Cardiovascular Diseases; Carnitine; Choline; Humans; Inflammation | 2022 |
Choline and butyrate beneficially modulate the gut microbiome without affecting atherosclerosis in APOE*3-Leiden.CETP mice.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Butyrates; Cholesterol Ester Transfer Proteins; Choline | 2022 |
GUT MICROBIOTA COMPOSITION AND ITS METABOLITES CHANGES IN PATIENTS WITH ATHEROSCLEROSIS AND ATRIAL FIBRILLATION.
Topics: Atherosclerosis; Atrial Fibrillation; Bacteria; Gastrointestinal Microbiome; Humans | 2022 |
Neither Trimethylamine-N-Oxide nor Trimethyllysine Is Associated with Atherosclerosis: A Cross-Sectional Study in Older Japanese Adults.
Topics: Animals; Atherosclerosis; Carnitine; Carotid Intima-Media Thickness; Choline; Cross-Sectional Studie | 2023 |
Chronic oral trimethylamine-N-oxide administration induces experimental incipient atherosclerosis in non-genetically modified mice.
Topics: Animals; Atherosclerosis; C-Reactive Protein; Cholesterol; Inflammation; Male; Mice; Oxides; Rats; R | 2022 |
TRIMETHYLAMINE OXIDE - FACTOR IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND A POTENTIAL TARGET FOR DIETARY AND PHARMACOLOGICAL INTERVENTIONS.
Topics: Atherosclerosis; Carnitine; Choline; Humans; Methylamines | 2023 |
Mangiferin alleviates trimethylamine-
Topics: Animals; Atherosclerosis; Cholesterol; Choline; Female; Gastrointestinal Microbiome; Methylamines; M | 2023 |
They eat, what we eat, they digest, what we ingest: the microbiome and the vulnerable plaque.
Topics: Atherosclerosis; Diet; Humans; Methylamines; Microbiota; Oxides; Plaque, Atherosclerotic | 2021 |
Zinc protoporphyrin-trimethylamine-N-oxide complex involves cholesterol oxidation causing atherosclerosis.
Topics: Atherosclerosis; Cholesterol; Coordination Complexes; Humans; Liver; Methylamines; Oxidation-Reducti | 2021 |
Berberine attenuates choline-induced atherosclerosis by inhibiting trimethylamine and trimethylamine-N-oxide production via manipulating the gut microbiome.
Topics: Animals; Atherosclerosis; Berberine; Choline; Diet; Disease Models, Animal; Disease Susceptibility; | 2021 |
Ligustrum robustum Alleviates Atherosclerosis by Decreasing Serum TMAO, Modulating Gut Microbiota, and Decreasing Bile Acid and Cholesterol Absorption in Mice.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cholesterol; Dietary Supplements; Female; Gastrointe | 2021 |
[Research progress of trimethylamine-N-oxide in the pathogenesis of atherosclerosis].
Topics: Atherosclerosis; Humans; Methylamines; Oxides | 2017 |
A Gut Feeling About Developmental Programming Mechanisms: Trimethylamine-N-Oxide May Enhance Atherosclerosis in Offspring of Hypercholesterolemic Mice.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Female; Hypercholesterolemia; Methylamines; Mice; Ox | 2017 |
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Mo | 2018 |
Human plasma concentrations of trimethylamine N-oxide extrapolated using pharmacokinetic modeling based on metabolic profiles of deuterium-labeled trimethylamine in humanized-liver mice.
Topics: Administration, Oral; Animals; Atherosclerosis; Deuterium; Hepatocytes; Humans; Methylamines; Mice; | 2018 |
Guggulsterone, a farnesoid X receptor antagonist lowers plasma trimethylamine-
Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Atherosclerosis; Cardiotonic Agents; Choline; Clost | 2019 |
Genetic Deficiency of Flavin-Containing Monooxygenase 3 ( Fmo3) Protects Against Thrombosis but Has Only a Minor Effect on Plasma Lipid Levels-Brief Report.
Topics: Animals; Atherosclerosis; Choline; Disease Models, Animal; Lipid Metabolism; Methylamines; Mice; Mic | 2019 |
FMO3 and its metabolite TMAO contribute to the formation of gallstones.
Topics: Animals; Atherosclerosis; ATP Binding Cassette Transporter, Subfamily G, Member 5; ATP Binding Casse | 2019 |
Oolong Tea Extract and Citrus Peel Polymethoxyflavones Reduce Transformation of l-Carnitine to Trimethylamine-
Topics: Animals; Atherosclerosis; Bacteria; Biotransformation; Camellia sinensis; Carnitine; Citrus; Female; | 2019 |
Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis.
Topics: Animals; Atherosclerosis; Bile Acids and Salts; Cell Line, Tumor; Diet, Western; DNA-Binding Protein | 2015 |
Transmission of atherosclerosis susceptibility with gut microbial transplantation.
Topics: Animals; Aorta; Atherosclerosis; Cecum; Choline; Diet; Disease Susceptibility; Female; Gastrointesti | 2015 |
Non-lethal Inhibition of Gut Microbial Trimethylamine Production for the Treatment of Atherosclerosis.
Topics: Animals; Apolipoproteins E; Atherosclerosis; Cholesterol; Choline; Diet; Feces; Foam Cells; Gastroin | 2015 |
Resveratrol Attenuates Trimethylamine-N-Oxide (TMAO)-Induced Atherosclerosis by Regulating TMAO Synthesis and Bile Acid Metabolism via Remodeling of the Gut Microbiota.
Topics: Animals; Atherosclerosis; Bacteria; Bile Acids and Salts; Cholesterol 7-alpha-Hydroxylase; Female; G | 2016 |
Dioxin-like pollutants increase hepatic flavin containing monooxygenase (FMO3) expression to promote synthesis of the pro-atherogenic nutrient biomarker trimethylamine N-oxide from dietary precursors.
Topics: Administration, Oral; Animals; Atherosclerosis; Biomarkers; Choline; Deuterium; Dietary Fats; Enviro | 2016 |
Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation.
Topics: Androgens; Animals; Atherosclerosis; Base Sequence; Bile Acids and Salts; Choline; Diet; Down-Regula | 2013 |