trimethoprim has been researched along with Toxoplasmosis, Animal in 22 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Toxoplasmosis, Animal: Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the chronic cystogenic murine models, the combination TMP plus SMX administered from day 5 for 15 days or from day 28 for 288 days, gave protection and even apparent toxoplasmal eradication ('cure') at the highest dosing (60/300 mg/kg per day)." | 1.30 | Evaluation of trimethoprim and sulphamethoxazole as monotherapy or in combination in the management of toxoplasmosis in murine models. ( Dumas, JL; Pechère, JC; Pizzolato, G, 1999) |
| "We examined the effect of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone, against Toxoplasma gondii." | 1.29 | Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii. ( Arsenijevic, D; Chang, HR; Comte, R; Pechère, JC; Polak, A; Then, RL, 1994) |
| "Thus epiroprim is an active and potentially less toxic alternative pyrimethamine for the treatment of toxoplasmosis." | 1.29 | Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice. ( Allegra, CJ; Kovacs, JA; Martinez, A, 1996) |
| "Five drug regimens for the treatment of acute toxoplasmosis were compared in a monkey model." | 1.27 | Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys. ( Harper, JS; London, WT; Sever, JL, 1985) |
| " By the suitable dosage the mortality rate could be reduced considerably." | 1.26 | [Experimental studies on the effect of the combination sulfamoxole/trimethoprim on the Toxoplasma infection of the mouse (author's transl)]. ( Maier, W; Piekarski, G, 1976) |
| "Trimethoprim was found to have no effect." | 1.25 | Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations. ( Seah, SK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (72.73) | 18.7374 |
| 1990's | 6 (27.27) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rosowsky, A | 1 |
| Papoulis, AT | 1 |
| Forsch, RA | 1 |
| Queener, SF | 1 |
| Nguyen, BT | 3 |
| Stadtsbaeder, S | 4 |
| Garin, JP | 1 |
| Paillard, B | 1 |
| Mehlhorn, H | 1 |
| Dankert, W | 1 |
| Hartman, PG | 1 |
| Then, RL | 2 |
| Chang, HR | 1 |
| Arsenijevic, D | 1 |
| Comte, R | 1 |
| Polak, A | 1 |
| Pechère, JC | 2 |
| Martinez, A | 1 |
| Allegra, CJ | 2 |
| Kovacs, JA | 2 |
| Brun-Pascaud, M | 1 |
| Chau, F | 1 |
| Garry, L | 1 |
| Jacobus, D | 1 |
| Derouin, F | 1 |
| Girard, PM | 1 |
| Dumas, JL | 1 |
| Pizzolato, G | 1 |
| Grossman, PL | 1 |
| Remington, JS | 2 |
| Thiermann, E | 1 |
| Apt, W | 1 |
| Atias, A | 1 |
| Lorca, M | 1 |
| Olguín, J | 1 |
| Coradello, H | 1 |
| Kretschmer, S | 1 |
| Maier, W | 1 |
| Piekarski, G | 1 |
| Seah, SK | 1 |
| Hamadto, HH | 1 |
| Rashed, SM | 1 |
| Marii, NE | 1 |
| Sobhy, MM | 1 |
| el-Ridi, AM | 1 |
| el-Fakahany, AF | 1 |
| Chabner, BA | 1 |
| Swan, JC | 1 |
| Drake, J | 1 |
| Lunde, M | 1 |
| Parrillo, JE | 1 |
| Masur, H | 1 |
| Harper, JS | 1 |
| London, WT | 1 |
| Sever, JL | 1 |
| Vischer, WA | 1 |
| Terragna, A | 1 |
| Rossolini, A | 1 |
| Cellesi, C | 1 |
| Figura, N | 1 |
| Barberi, A | 1 |
| Calvin-Preval, MC | 1 |
22 other studies available for trimethoprim and Toxoplasmosis, Animal
| Article | Year |
|---|---|
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Topics: Animals; Antifungal Agents; Antineoplastic Agents; Antiprotozoal Agents; Cell Line; Drug Screening A | 1999 |
[Therapeutic future of trimethoprim-sulfamethoxazole in toxoplasmosis].
Topics: Animals; Drug Combinations; Female; Humans; Mice; Pregnancy; Sulfamethoxazole; Toxoplasmosis; Toxopl | 1983 |
[Experimental toxoplasmosis in mice. Comparative activity of clindamycin, midecamycin, josamycin, spiramycin, pyrimethamine-sulfadoxine, and trimethoprim-sulfamethoxazole].
Topics: Animals; Clindamycin; Drug Combinations; Leucomycins; Mice; Pyrimethamine; Sulfadoxine; Sulfamethoxa | 1984 |
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole), pyrimethamine-sulphadiazine and spiramycin during avirulent infection with Toxoplasma gondii (Beverley strain) in mice.
Topics: Animals; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Female; Leucomyci | 1983 |
A pilot study on the efficacy of epiroprim against developmental stages of Toxoplasma gondii and Pneumocystis carinii in animal models.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Dapsone; Drug Therapy, Combination; Female; F | 1995 |
Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii.
Topics: Animals; Dapsone; Drug Synergism; Female; Folic Acid Antagonists; Mice; Toxoplasma; Toxoplasmosis, A | 1994 |
Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice.
Topics: Acute Disease; Administration, Oral; Animals; Anti-Infective Agents; Antiprotozoal Agents; Dapsone; | 1996 |
Combination of PS-15, epiroprim, or pyrimethamine with dapsone in prophylaxis of Toxoplasma gondii and Pneumocystis carinii dual infection in a rat model.
Topics: Animals; Anti-Bacterial Agents; Antiprotozoal Agents; Dapsone; Drug Therapy, Combination; Folic Acid | 1996 |
Evaluation of trimethoprim and sulphamethoxazole as monotherapy or in combination in the management of toxoplasmosis in murine models.
Topics: Animals; Chronic Disease; Disease Models, Animal; Drug Evaluation; Mice; Sulfamethoxazole; Toxoplasm | 1999 |
The effect of trimethoprim and sulfamethoxazole on Toxoplasma gondii in vitro and in vivo.
Topics: Administration, Oral; Animals; Culture Techniques; Dose-Response Relationship, Drug; Drug Therapy, C | 1979 |
A comparative study of some combined treatment regimens in acute toxoplasmosis in mice.
Topics: Acute Disease; Animals; Clindamycin; Drug Therapy, Combination; Humans; Leucomycins; Mice; Pyrimetha | 1978 |
[A comparison of Ultrax, Diazil, Bactrim and Spiramycin in experimental toxoplasmosis in mice (author's transl)].
Topics: Animals; Injections, Subcutaneous; Leucomycins; Mice; Pyrimethamine; Sulfameter; Sulfamethazine; Sul | 1978 |
[Experimental studies on the effect of the combination sulfamoxole/trimethoprim on the Toxoplasma infection of the mouse (author's transl)].
Topics: Animals; Drug Combinations; Mice; Sulfamethoxazole; Sulfamoxole; Toxoplasmosis, Animal; Trimethoprim | 1976 |
Chemotherapy in experimental toxoplasmosis: comparison of the efficacy of trimethoprim-sulfur and pyrimethamine-sulfur combinations.
Topics: Animals; Drug Combinations; Drug Evaluation; Female; Mice; Pyrimethamine; Sulfadiazine; Sulfamethoxa | 1975 |
Trimethoprim-sulfamethoxazole in murine toxoplasmosis.
Topics: Animals; Drug Therapy, Combination; Mice; Sulfamethoxazole; Toxoplasmosis, Animal; Trimethoprim | 1976 |
The effect of some drugs on acute toxoplasmosis in mice.
Topics: Animals; Chloroquine; Clindamycin; Drug Combinations; Levamisole; Mice; Praziquantel; Sulfamethoxazo | 1989 |
Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.
Topics: Animals; Cells, Cultured; Drug Therapy, Combination; Folic Acid Antagonists; Macrophages; Mice; Mice | 1987 |
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole) and spiramycin in pregnant mice infected with Toxoplasma gondii (Beverley strain).
Topics: Animals; Antibodies; Birth Weight; Congenital Abnormalities; Delivery, Obstetric; Drug Combinations; | 1985 |
Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.
Topics: Animals; Clindamycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leuco | 1985 |
[Comparative study on the effect of some clinically used sulfanilamide derivatives against toxoplasmosis in the mouse].
Topics: Aminobenzoates; Animals; Dapsone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Syn | 1973 |
Activity of the combination trimethoprim-sulfamethoxazole on experimental toxoplasmosis.
Topics: Animals; Drug Combinations; Fluorescent Antibody Technique; Histocytochemistry; Liver; Mice; Succina | 1973 |
[The trimethoprim-sulfamethoxazole association in experimental toxoplasmosis in mice].
Topics: Animals; Mice; Sulfamethoxazole; Toxoplasmosis, Animal; Trimethoprim | 1973 |