trimethoprim has been researched along with Thrombopenia in 40 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The efficacy of orally administered trimethoprim-sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol-resistant and endemic chloramphenicol-sensitive Salmonella typhi." | 9.04 | Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever. ( Calderone, E; Gilman, RH; Hernandez-Mendosa, P; Hornick, RB; Levine, MM; Martinez, E; Snyder, MJ; Terminel, M; Vasquez, V, 1975) |
| "A diagnosis of trimethoprim/sulfadiazine-induced, immune-mediated thrombocytopenia in a dog was made, using a novel in vitro assay for thrombolytic activity." | 7.68 | Thrombocytopenia associated with administration of trimethoprim/sulfadiazine in a dog. ( Arrington, K; McDonald, TP; Sullivan, PS; West, R, 1992) |
| "Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole." | 7.66 | Thrombocytopenia secondary to trimethoprim-sulfamethoxazole. ( Hagen, MD; White, RD, 1983) |
| "A 3-year-old white boy had symptomatic thrombocytopenia after receiving trimethoprim-sulfamethoxazole in recommended doses for one week." | 7.66 | Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole. ( Luban, NL; Rodriguez, WJ; Schwartz, RH, 1981) |
| "Thrombocytopenia is an uncommon but serious side effect of the antimicrobial combination of trimethoprim and sulphamethoxazole." | 7.66 | Trimethoprim-sulphamethoxazole and thrombocytopenia. ( Dickson, HG, 1978) |
| "The efficacy of orally administered trimethoprim-sulfamethoxazole was compared with that of oral amoxicillin in therapy of typhoid fever due to both epidemic chloramphenicol-resistant and endemic chloramphenicol-sensitive Salmonella typhi." | 5.04 | Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever. ( Calderone, E; Gilman, RH; Hernandez-Mendosa, P; Hornick, RB; Levine, MM; Martinez, E; Snyder, MJ; Terminel, M; Vasquez, V, 1975) |
| "A diagnosis of trimethoprim/sulfadiazine-induced, immune-mediated thrombocytopenia in a dog was made, using a novel in vitro assay for thrombolytic activity." | 3.68 | Thrombocytopenia associated with administration of trimethoprim/sulfadiazine in a dog. ( Arrington, K; McDonald, TP; Sullivan, PS; West, R, 1992) |
| "Two patients had severe thrombocytopenia while taking trimethoprim-sulfamethoxazole." | 3.66 | Thrombocytopenia secondary to trimethoprim-sulfamethoxazole. ( Hagen, MD; White, RD, 1983) |
| "A 3-year-old white boy had symptomatic thrombocytopenia after receiving trimethoprim-sulfamethoxazole in recommended doses for one week." | 3.66 | Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole. ( Luban, NL; Rodriguez, WJ; Schwartz, RH, 1981) |
| " He developed severe thrombocytopenia when pentamidine was added to the regimen." | 3.66 | Treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity. ( Milder, JE; Powell, RD; Walzer, PD, 1979) |
| "Thrombocytopenia is an uncommon but serious side effect of the antimicrobial combination of trimethoprim and sulphamethoxazole." | 3.66 | Trimethoprim-sulphamethoxazole and thrombocytopenia. ( Dickson, HG, 1978) |
| "12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia." | 1.27 | Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. ( Bygbjerg, IC; Hørding, M; Lund, JT, 1988) |
| "Thrombocytopenia is a common serious adverse effect of drug treatment." | 1.26 | Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro. ( Barr, R; Bianchi, F; Carter, CJ; Giles, AR; Hirsh, J; Kelton, JG; Meltzer, D; Moore, J; Neame, PB; Powers, PJ; Walker, I; Wilson, WE, 1981) |
| "Thrombocytopenia was noted between the seventh and 16th day (mean, 10." | 1.26 | Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children. ( Asmar, BI; Dajani, AS; Maqbool, S, 1981) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 35 (87.50) | 18.7374 |
| 1990's | 3 (7.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (5.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mitta, A | 1 |
| Curtis, BR | 1 |
| Reese, JA | 1 |
| George, JN | 1 |
| Worthing, KA | 1 |
| Norris, JM | 1 |
| Briscoe, KA | 1 |
| Ahmad, S | 1 |
| McGeady, SJ | 1 |
| Murphey, SA | 1 |
| Hagen, MD | 1 |
| White, RD | 1 |
| Preisler, HD | 1 |
| Early, A | 1 |
| Hryniuk, W | 1 |
| Barr, AL | 1 |
| Whineray, M | 1 |
| Kelton, JG | 1 |
| Meltzer, D | 1 |
| Moore, J | 1 |
| Giles, AR | 1 |
| Wilson, WE | 1 |
| Barr, R | 1 |
| Hirsh, J | 1 |
| Neame, PB | 1 |
| Powers, PJ | 1 |
| Walker, I | 1 |
| Bianchi, F | 1 |
| Carter, CJ | 1 |
| Lanzkowsky, P | 1 |
| Schaeffer, J | 1 |
| Bradley, PP | 1 |
| Warden, GD | 1 |
| Maxwell, JG | 1 |
| Rothstein, G | 1 |
| Guess, HA | 1 |
| Cohen, MS | 1 |
| Schwartz, RH | 1 |
| Rodriguez, WJ | 1 |
| Luban, NL | 1 |
| Stockman, JA | 1 |
| Asmar, BI | 1 |
| Maqbool, S | 1 |
| Dajani, AS | 1 |
| Nenci, GG | 1 |
| Agnelli, G | 1 |
| Berrettini, M | 1 |
| Nielsen, HV | 1 |
| Hawkins, T | 1 |
| Carter, JM | 1 |
| Romeril, KR | 1 |
| Jackson, SR | 1 |
| Green, GJ | 1 |
| Dodds, WJ | 1 |
| Gilman, RH | 1 |
| Terminel, M | 1 |
| Levine, MM | 1 |
| Hernandez-Mendosa, P | 1 |
| Calderone, E | 1 |
| Vasquez, V | 1 |
| Martinez, E | 1 |
| Snyder, MJ | 1 |
| Hornick, RB | 1 |
| Milder, JE | 1 |
| Walzer, PD | 1 |
| Powell, RD | 1 |
| Dickson, HG | 1 |
| Bosset, JF | 1 |
| Faivre, R | 1 |
| Rozenbaum, A | 1 |
| Flesch, M | 1 |
| Leconte Des Floris, R | 1 |
| Girdwood, RH | 1 |
| Sullivan, PS | 1 |
| Arrington, K | 1 |
| West, R | 1 |
| McDonald, TP | 1 |
| Israel, HL | 1 |
| Bygbjerg, IC | 1 |
| Lund, JT | 1 |
| Hørding, M | 1 |
| Heimpel, H | 1 |
| Raghavachar, A | 1 |
| Verma, A | 1 |
| Maheshwari, MC | 1 |
| First, LR | 1 |
| Smith, BR | 1 |
| Lipton, J | 1 |
| Nathan, DG | 1 |
| Parkman, R | 1 |
| Rappeport, JM | 1 |
| Nielsen, ML | 1 |
| Laursen, H | 1 |
| Christensen, P | 1 |
| Böse, W | 1 |
| Karama, A | 1 |
| Linzenmeier, G | 1 |
| Olbing, H | 1 |
| Wellmann, P | 1 |
| Frisch, JM | 1 |
| Kerstan, J | 1 |
| Wolf, H | 1 |
| Casey, TP | 1 |
| Matthews, JR | 1 |
| Buchanan, JG | 1 |
| Herbert, V | 1 |
| Raik, E | 1 |
| Vincent, PC | 1 |
| Veen, MR | 1 |
| Toghill, PJ | 1 |
| Ryrie, DR | 1 |
| Tanna, MK | 1 |
| Tattersall, RB | 1 |
| Maier, C | 1 |
| Heer, HR | 1 |
| Wegmüller, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Azacitidine (AZA) Combined With N-Acetyl-L-cysteine (NAC) for Prolonged Isolated Thrombocytopenia (PIT) After Hematopoietic Stem Cell Transplantation (HSCT)[NCT05126004] | Phase 2 | 100 participants (Anticipated) | Interventional | 2021-12-01 | Not yet recruiting | ||
| A Prospective Study of Patients With Isolated Thrombocytopenia Following Hematopoietic Stem Cell Transplantation[NCT02487563] | Phase 3 | 97 participants (Actual) | Interventional | 2015-10-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The total number of megakaryocytes as well as the platelet-shedding megakaryocytes of bone marrow smears (per cm2) was counted and cross-checked by blinded observers. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | cells/cm^2 (Median) |
|---|---|
| Experimental Group 1 | 6.7 |
| Experimental Group 2 | 7.5 |
| Control Group | 3.3 |
Platelet response refers to a sustained increase (stable or increasing level) of at least 30×10E9/L independent of transfusion for 3 days. (NCT02487563)
Timeframe: Up to 4 weeks after the treatment
| Intervention | Participants (Count of Participants) |
|---|---|
| Experimental Group 1 | 20 |
| Experimental Group 2 | 22 |
| Control Group | 6 |
3 reviews available for trimethoprim and Thrombopenia
| Article | Year |
|---|---|
Drug-induced thrombocytopenia: 2019 Update of clinical and laboratory data.
Topics: Anti-Bacterial Agents; Autoantibodies; Blood Platelets; Dexamethasone; Exenatide; Flavonoids; Humans | 2019 |
Hematological side effects of co-trimoxazole.
Topics: Anemia; Anti-Infective Agents; Blood Cells; Drug Combinations; Humans; Leukopenia; Risk; Sulfamethox | 1987 |
Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man.
Topics: Agranulocytosis; Aminobenzoates; Anemia; Bile; Biological Transport, Active; Bone Marrow; Bone Marro | 1973 |
2 trials available for trimethoprim and Thrombopenia
| Article | Year |
|---|---|
Comparison of trimethoprim-sulfamethoxazole and amoxicillin in therapy of chloramphenicol-resistant and chloramphenicol-sensitive typhoid fever.
Topics: Adolescent; Adult; Amoxicillin; Ampicillin; Child; Chloramphenicol; Clinical Trials as Topic; Drug C | 1975 |
Controlled trial of co-trimoxazole in children with urinary-tract infection. Bacteriological efficacy and haematological toxicity.
Topics: Adolescent; Ampicillin; Bacteriuria; Blood Cell Count; Blood Platelets; Child; Child, Preschool; Cli | 1974 |
35 other studies available for trimethoprim and Thrombopenia
| Article | Year |
|---|---|
Severe acute cellulitis and sepsis caused by Aeromonas spp. in a dog on immunosuppressive therapy.
Topics: Aeromonas; Animals; Anti-Bacterial Agents; Cellulitis; Dog Diseases; Dogs; Drug Combinations; Female | 2019 |
Severe thrombocytopenia-hemorrhage due to trimethoprim-sulfamethoxazole: a case report.
Topics: Aged; Anti-Infective Agents, Urinary; Drug Combinations; Escherichia coli Infections; Female; Hematu | 1984 |
Disseminated Mycobacterium kansasii infection.
Topics: Cardiomegaly; Child, Preschool; Disseminated Intravascular Coagulation; Heart Failure; Humans; Immun | 1981 |
Thrombocytopenia secondary to trimethoprim-sulfamethoxazole.
Topics: Acute Disease; Child, Preschool; Drug Therapy, Combination; Female; Folic Acid; Humans; Male; Middle | 1983 |
Prevention of infection and bleeding in leukemic patients receiving intensive remission maintenance therapy.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Bacterial Infections; Drug Combinations; Female | 1981 |
Immune thrombocytopenia induced by cotrimoxazole.
Topics: Adult; Autoantibodies; Autoimmune Diseases; Blood Platelets; Drug Combinations; Female; Humans; Sulf | 1980 |
Drug-induced thrombocytopenia is associated with increased binding of IgG to platelets both in vivo and in vitro.
Topics: Adult; Aged; Antibodies, Antinuclear; Binding Sites, Antibody; Blood Platelets; Child; Convalescence | 1981 |
Prophylactic use of TMP-SMZ in leukemia.
Topics: Agranulocytosis; Child; Drug Combinations; Humans; Leukemia, Lymphoid; Neutropenia; Pulmonary Fibros | 1982 |
Neutropenia and thrombocytopenia in renal allograft recipients treated with trimethoprim-sulfamethoxazole.
Topics: Adult; Agranulocytosis; Azathioprine; Bone Marrow; Drug Combinations; Drug Synergism; Humans; Kidney | 1980 |
Drug treatment of otitis media and urinary tract infections.
Topics: Agranulocytosis; Child; Humans; Neutropenia; Otitis Media; Sulfamethoxazole; Thrombocytopenia; Trime | 1982 |
Thrombocytopenia associated with PF3 antiplatelet activity against the sulfa component of trimethoprim-sulfamethoxazole.
Topics: Blood Coagulation Factors; Child, Preschool; Humans; Male; Platelet Factor 3; Sulfamethoxazole; Thro | 1981 |
Trimethoprim-sulfamethoxazole therapy. Everything's not turning up roses.
Topics: Bacterial Infections; Child; Drug Combinations; Humans; Neutropenia; Sulfamethoxazole; Thrombocytope | 1981 |
Hematologic abnormalities after oral trimethoprim-sulfamethoxazole therapy in children.
Topics: Amoxicillin; Anemia; Blood; Child; Child, Preschool; Drug Therapy, Combination; Eosinophilia; Female | 1981 |
[Acute immunoallergic thrombopenia due to sulfamethoxazole-trimethoprim].
Topics: Acute Disease; Drug Hypersensitivity; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethoprim | 1980 |
[Thrombocytopenia during treatment with sulphamethoxazole with trimethoprim].
Topics: Aged; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethoprim | 1980 |
Severe trimethoprim induced neutropenia and thrombocytopenia.
Topics: Adult; Aged; Aged, 80 and over; Female; Humans; Neutropenia; Thrombocytopenia; Trimethoprim | 1993 |
Hemorrhagic complications attributable to certain drugs.
Topics: Animals; Cat Diseases; Cats; Dog Diseases; Dogs; Drug Combinations; Hemorrhage; Sulfonamides; Thromb | 1993 |
Treatment of Pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity.
Topics: Adult; Amidines; Drug Combinations; Drug Therapy, Combination; Humans; Male; Pentamidine; Pneumonia, | 1979 |
Trimethoprim-sulphamethoxazole and thrombocytopenia.
Topics: Adolescent; Adult; Age Factors; Animals; Child, Preschool; Drug Combinations; Female; Humans; Infant | 1978 |
[Acute thrombopenia during treatment with sulfamethoxazole-trimethoprim].
Topics: Acute Disease; Adult; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimeth | 1978 |
The nature of possible adverse reactions to co-trimoxazole.
Topics: Aminopterin; Anemia, Megaloblastic; Chemical Phenomena; Chemistry; Drug Combinations; Folic Acid; Hu | 1976 |
Thrombocytopenia associated with administration of trimethoprim/sulfadiazine in a dog.
Topics: Animals; Anti-Infective Agents; Blood Platelets; Dog Diseases; Dogs; Drug Combinations; Epistaxis; F | 1992 |
Sulfamethoxazole-trimethoprim therapy for Wegener's granulomatosis.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Combinations; Female; Granulom | 1988 |
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Drug Combinations; Folic Acid; Hem | 1988 |
Spontaneous thalamic haemorrhage in drug-induced thrombocytopenia.
Topics: Adult; Cerebral Hemorrhage; Drug Combinations; Female; Humans; Sulfamethizole; Sulfathiazoles; Thala | 1987 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Isolated thrombocytopenia after allogeneic bone marrow transplantation: existence of transient and chronic thrombocytopenic syndromes.
Topics: Actuarial Analysis; Adolescent; Adult; Azathioprine; Bone Marrow; Bone Marrow Transplantation; Child | 1985 |
Control of bacteriuria with sulphamethoxazole-trimethoprim in patients with urinary tract obstruction and chronic infection. A preliminary report.
Topics: Adult; Aged; Anti-Infective Agents; Bacteriuria; Female; Folic Acid Antagonists; Humans; Male; Middl | 1972 |
Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Child; Depression; Drug Combinations; D | 1973 |
[Therapeutic experience with trimethoprim and sulfamethoxazole in infections of infancy and childhood].
Topics: Adolescent; Anti-Infective Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Drug S | 1972 |
Adverse haematological effects and trimethoprim-sulphamethoxazole administration.
Topics: Aged; Agranulocytosis; Anemia; Child; Drug Combinations; Female; Hematologic Diseases; Humans; Male; | 1973 |
Letter: Thrombocytopenia with combined trimethoprim-sulphamethoxazole and allopurinol therapy.
Topics: Aged; Allopurinol; Drug Combinations; Female; Humans; Sulfamethoxazole; Thrombocytopenia; Trimethopr | 1973 |
[Side effects of trimethoprim-sulfamethoxazole (co-trimoxazole)].
Topics: Adult; Aged; Crystallization; Humans; Leukopenia; Male; Sulfamethoxazole; Thrombocytopenia; Trimetho | 1973 |
Induction of remission in myeloblastic and monoblastic leukaemia in adults with rubidomycin.
Topics: Adolescent; Adult; Aged; Alopecia; Ampicillin; Anemia, Aplastic; Antibiotics, Antineoplastic; Blood | 1971 |
[Studies on the hematologic tolerance of Bactrim].
Topics: Anti-Infective Agents; Erythrocytes; Folic Acid Antagonists; Folic Acid Deficiency; Hematologic Dise | 1972 |
[Treatment of chronically recurring urinary tract infection with trimethoprim sulfamethoxazole (Eusaprim)].
Topics: Adult; Aged; Anti-Infective Agents; Chronic Disease; Female; Folic Acid Antagonists; Gastrointestina | 1970 |