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trimethoprim and Streptococcal Infections

trimethoprim has been researched along with Streptococcal Infections in 52 studies

Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.

Streptococcal Infections: Infections with bacteria of the genus STREPTOCOCCUS.

Research Excerpts

ExcerptRelevanceReference
"Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection."9.04Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975)
"Horses with lower respiratory tract infections caused by S equi subsp zooepidemicus were treated with a new formulation of combined trimethoprim-sulfadiazine oral suspension at a dosage of 24 mg/kg (10."5.20A randomized controlled field trial of a novel trimethoprim-sulfadiazine oral suspension for treatment of Streptococcus equi subsp zooepidemicus infection of the lower respiratory tract in horses. ( Hawkins, PA; Koenig, R; McClure, SR, 2015)
"We evaluated the following five treatment regimens for acute cystitis in nonpregnant women: cefadroxil, 1,000 mg single-dose; cefadroxil, 500 mg twice a day for three days; cefadroxil, 500 mg twice a day for seven days; trimethoprim-sulfamethoxazole (TMP-SMZ), 320-1,600 mg single-dose, and TMP-SMZ, 160-800 mg twice a day for three days."5.06Randomized study of single-dose, three-day, and seven-day treatment of cystitis in women. ( Bollinger, MR; Ellington, LL; Greenberg, RN; Luppen, KL; Reilly, PM; Weinandt, WJ, 1986)
"Of 545 patients expected to develop prolonged neutropenia and randomized to received trimethoprim-sulfamethoxazole (TMP-SMZ) or placebo, 342 were evaluable for occurrence of infection or bacteremia."5.05Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. EORTC International Antimicrobial Therapy Project Group. ( , 1984)
"Seventy-nine children with acute otitis media were the subjects in a study designed to compare the effectiveness of ampicillin and trimethoprim-sulfamethoxazole in this infection."5.04Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media. ( Cameron, GG; Johnston, MT; Pomahac, AC, 1975)
"Ninety patients with urinary tract infections were treated in a randomized double-blind study with either a combination of trimethoprim and sulfamethoxazole (TMP-SMX) or sulfamethoxazole alone (SMX)."5.04A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys. ( Boutros, P; Harding, GK; Lank, B; Ronald, AR, 1975)
"Two patients with uncomplicated enterococcal urinary tract infections were treated with trimethoprim-sulfamethoxazole based on in vitro susceptibilities."3.67In vivo v in vitro susceptibility of enterococcus to trimethoprim-sulfamethoxazole. A pitfall. ( Goodhart, GL, 1984)
"Trimethoprim was found in higher concentrations in the sputum than in the blood, although there were wide and significant variations in individual patient's sputum pharmacokinetic profiles."2.66Trimethoprim alone compared to co-trimoxazole in lower respiratory infections: pharmacokinetics and clinical effectiveness. ( Brumfitt, W; Hamilton-Miller, JM; Havard, CW; Tansley, H, 1985)
"Aditoprim (ADP) has potential use as an antimicrobial agent in animals."1.46The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. ( Chen, D; Cheng, G; Hao, H; Huang, L; Liu, Z; Pan, Y; Wang, L; Wang, Y; Xie, S; Xu, Y; Yuan, Z; Zhu, X, 2017)
"Trimethoprim/sulfadiazine treatment resulted in a marked reduction of viable bacteria in the tissue chamber but did not eliminate the infection, resulting in abscessation from day 19 onwards in all six ponies."1.33Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies. ( Bosch, G; Ensink, JM; van Duijkeren, E, 2005)

Research

Studies (52)

TimeframeStudies, this research(%)All Research%
pre-199044 (84.62)18.7374
1990's2 (3.85)18.2507
2000's4 (7.69)29.6817
2010's2 (3.85)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McClure, SR1
Koenig, R1
Hawkins, PA1
Cheng, G1
Xu, Y1
Zhu, X1
Xie, S1
Wang, L1
Huang, L1
Hao, H1
Liu, Z1
Pan, Y1
Chen, D1
Wang, Y1
Yuan, Z1
Donnenfeld, ED1
O'Brien, TP1
Solomon, R1
Perry, HD1
Speaker, MG1
Wittpenn, J1
Ensink, JM2
Smit, JA1
van Duijkeren, E2
Bosch, G1
Brochet, M1
Couvé, E1
Zouine, M1
Poyart, C1
Glaser, P1
Breitenbucher, RB1
Goodhart, GL1
Belli, DC1
Auckenthaler, R1
Paunier, L1
Ferrier, PE1
Frame, PT1
McLaurin, RL1
Hoskins, TW1
Bernstein, LS1
Layes Molla, A1
Donald, JF1
Powers, TE1
Powers, JD1
Garg, RC1
Scialli, VT1
Hajian, GH1
Golland, LC1
Hodgson, DR1
Davis, RE1
Rawlinson, RJ1
Collins, MB1
McClintock, SA1
Hutchins, DR1
Hawkins, JF1
Lescun, TB1
Hamory, BH1
Sande, MA1
Sydnor, A1
Seale, DL1
Gwaltney, JM1
Pomahac, AC2
Bajpai, J1
Chaturvedi, SN1
Khanuja, SP1
Benn, RA1
Kurzynski, TA1
Meise, CK1
Dykstra, MA1
McLaughlin, JC1
Bartlett, RC1
Ardati, KO1
Thirumoorthi, MC1
Dajani, AS1
Sher, N1
Cameron, GG1
Johnston, MT1
Harding, GK1
Ronald, AR1
Boutros, P1
Lank, B1
Výmola, F1
Jedlicková, Z1
Hamilton-Miller, JM3
Lohr, JA1
Austin, RD1
Grossman, M1
Hayden, GF1
Knowlton, GM1
Dudley, SM1
Purves, D1
Tuncer, AM1
Kunak, B1
Kirsaç, N1
Yeğinaltay, T1
Kotiloğlu, G1
Can, R1
Güngör, A1
Nalça, M1
Greenberg, RN1
Reilly, PM1
Luppen, KL1
Weinandt, WJ1
Ellington, LL1
Bollinger, MR1
Tokatli, A1
Topçu, M1
Ozkutlu, S1
Akçevim, A1
Marks, MI1
Wüst, J1
Kayser, FH1
Morenzoni, G1
Guise, HJ2
Penny, RH2
Petherick, DJ1
Brumfitt, W1
Havard, CW1
Tansley, H1
Hansman, D1
Morris, S1
Gregory, M1
McDonald, B1
Räisänen, S1
Ylitalo, P1
Toponen, A1
Seppänen, J1
Duthie, AN1
Quick, CA1
Wagner, D1
Drach, GW1
Niutta, R1
Urciuoli, A1
Trickett, PC1
Dineen, P1
Mogabgab, W1
Geddes, AM1
Chattopadhyay, B1
Wesolowski, J1
Trznadel, K1
Maciejek, Z1
Seligman, SJ1
Madhavan, T1
Alcid, D1
Hoffer, M1
Grunberg, E1
Mitrovic, M1
Brossi, A1
Tauchnitz, C1
Renzini, G1
Ravagnan, G1
Bormioli, P1
D'Alessandro, A1
Kühni, M1
Böhni, E1
Gamba, G1
Braunsteiner, A1

Reviews

4 reviews available for trimethoprim and Streptococcal Infections

ArticleYear
Infectious keratitis after photorefractive keratectomy.
    Ophthalmology, 2003, Volume: 110, Issue:4

    Topics: Adult; Ciprofloxacin; Corneal Ulcer; Cross Infection; Drug Therapy, Combination; Eye Infections, Bac

2003
Antibiotics: use and abuse in office practice.
    Drugs, 1977, Volume: 13, Issue:4

    Topics: Anti-Bacterial Agents; Cephalosporins; Clindamycin; Erythromycin; Fusidic Acid; Humans; Kidney Disea

1977
New applications of old antimicrobials.
    Pediatric annals, 1986, Volume: 15, Issue:6

    Topics: Anti-Bacterial Agents; Bacterial Infections; Child; Chloramphenicol; Drug Combinations; Haemophilus

1986
Chemotherapy.
    The Practitioner, 1974, Volume: 213, Issue:1276 SPEC

    Topics: Aminoglycosides; Ampicillin; Anti-Infective Agents; Antifungal Agents; Antitubercular Agents; Antivi

1974

Trials

12 trials available for trimethoprim and Streptococcal Infections

ArticleYear
A randomized controlled field trial of a novel trimethoprim-sulfadiazine oral suspension for treatment of Streptococcus equi subsp zooepidemicus infection of the lower respiratory tract in horses.
    Journal of the American Veterinary Medical Association, 2015, Jun-15, Volume: 246, Issue:12

    Topics: Administration, Oral; Animals; Drug Combinations; Female; Horse Diseases; Horses; Male; Respiratory

2015
Clinical efficacy of trimethoprim/sulfadiazine and procaine penicillin G in a Streptococcus equi subsp. zooepidemicus infection model in ponies.
    Journal of veterinary pharmacology and therapeutics, 2003, Volume: 26, Issue:4

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Drug Combinations; Drug Therapy, Combination;

2003
Trimethoprim-sulfamethoxazole in the prevention of infection in neutropenic patients. EORTC International Antimicrobial Therapy Project Group.
    The Journal of infectious diseases, 1984, Volume: 150, Issue:3

    Topics: Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topic; Drug Combina

1984
Trimethoprim/sulphadiazine compared with penicillin V in the treatment of streptococcal throat infections.
    The Journal of antimicrobial chemotherapy, 1981, Volume: 8, Issue:6

    Topics: Adolescent; Child; Drug Therapy, Combination; Humans; Male; Penicillin V; Streptococcal Infections;

1981
A comparison of Bracen and co-trimoxazole in the treatment of acute respiratory tract infections in children.
    The Journal of international medical research, 1982, Volume: 10, Issue:4

    Topics: Acute Disease; Anti-Infective Agents; Camphanes; Child; Child, Preschool; Drug Combinations; England

1982
Comparative efficacy of ampicillin and trimethoprim-sulfamethoxazole in otitis media.
    Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No

    Topics: Administration, Oral; Ampicillin; Bacterial Infections; Body Weight; Child; Clinical Trials as Topic

1975
A comparison of trimethorprim-sulfamethoxazole with sulfamethoxazole alone in infections localized to the kidneys.
    Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No

    Topics: Administration, Oral; Adolescent; Adult; Aged; Bacterial Infections; Clinical Trials as Topic; Drug

1975
Comparison of three topical antimicrobials for acute bacterial conjunctivitis.
    The Pediatric infectious disease journal, 1988, Volume: 7, Issue:9

    Topics: Administration, Topical; Adolescent; Adult; Child; Child, Preschool; Conjunctivitis, Bacterial; Drug

1988
Randomized study of single-dose, three-day, and seven-day treatment of cystitis in women.
    The Journal of infectious diseases, 1986, Volume: 153, Issue:2

    Topics: Administration, Oral; Antibody-Coated Bacteria Test, Urinary; Bacteriuria; Cefadroxil; Cystitis; Dru

1986
Trimethoprim alone compared to co-trimoxazole in lower respiratory infections: pharmacokinetics and clinical effectiveness.
    Scandinavian journal of infectious diseases, 1985, Volume: 17, Issue:1

    Topics: Adolescent; Adult; Aged; Drug Combinations; Female; Haemophilus Infections; Haemophilus influenzae;

1985
Trimethoprim-sulfamethoxazole in the treatment of infections of the ears, nose, and throat.
    The Journal of infectious diseases, 1973, Volume: 128

    Topics: Acute Disease; Bacterial Infections; Chronic Disease; Clinical Trials as Topic; Haemophilus Infectio

1973
Clinical experience: respiratory tract. Trimethoprim-sulfamethoxazole versus penicillin G in the treatment of group A beta-hemolytic streptococcal pharyngitis and tonsillitis.
    The Journal of infectious diseases, 1973, Volume: 128

    Topics: Adolescent; Clinical Trials as Topic; Drug Combinations; Humans; Penicillin G; Pharyngitis; Pharynx;

1973

Other Studies

36 other studies available for trimethoprim and Streptococcal Infections

ArticleYear
The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis.
    Scientific reports, 2017, 02-01, Volume: 7

    Topics: Animals; Anti-Bacterial Agents; Microbial Sensitivity Tests; Streptococcal Infections; Swine; Swine

2017
Clinical efficacy of prophylactic administration of trimethoprim/sulfadiazine in a Streptococcus equi subsp. zooepidemicus infection model in ponies.
    Journal of veterinary pharmacology and therapeutics, 2005, Volume: 28, Issue:1

    Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Antibiotic Prophylaxis; Disease Models, Animal

2005
A naturally occurring gene amplification leading to sulfonamide and trimethoprim resistance in Streptococcus agalactiae.
    Journal of bacteriology, 2008, Volume: 190, Issue:2

    Topics: Anti-Bacterial Agents; Dihydropteroate Synthase; DNA, Bacterial; Drug Resistance, Bacterial; Folic A

2008
Bacterial changes in the urine samples of patients with long-term indwelling catheters.
    Archives of internal medicine, 1984, Volume: 144, Issue:8

    Topics: Adult; Aged; Anti-Infective Agents, Urinary; Bacteriuria; Catheters, Indwelling; Citrobacter; Drug C

1984
In vivo v in vitro susceptibility of enterococcus to trimethoprim-sulfamethoxazole. A pitfall.
    JAMA, 1984, Nov-16, Volume: 252, Issue:19

    Topics: Drug Combinations; Drug Therapy, Combination; Female; Humans; Male; Microbial Sensitivity Tests; Mid

1984
Throat cultures for group A beta-hemolytic Streptococcus. Importance of anaerobic incubation.
    American journal of diseases of children (1960), 1984, Volume: 138, Issue:3

    Topics: Anaerobiosis; Bacteriological Techniques; Child; Child, Preschool; Culture Media; Drug Combinations;

1984
Treatment of CSF shunt infections with intrashunt plus oral antibiotic therapy.
    Journal of neurosurgery, 1984, Volume: 60, Issue:2

    Topics: Administration, Oral; Cerebrospinal Fluid Shunts; Child; Child, Preschool; Corynebacterium Infection

1984
Trimethoprim and sulfadiazine: experimental infection of Beagles.
    American journal of veterinary research, 1980, Volume: 41, Issue:7

    Topics: Animals; Blood; Dog Diseases; Dogs; Drug Combinations; Female; Injections, Subcutaneous; Male; Strep

1980
Retropharyngeal lymph node infection in horses: 46 cases (1977-1992).
    Australian veterinary journal, 1995, Volume: 72, Issue:5

    Topics: Administration, Oral; Animals; Drainage; Drug Therapy, Combination; Female; Horse Diseases; Horses;

1995
Sepsis of the common digital extensor tendon sheath secondary to hemicircumferential periosteal transection in a foal.
    Journal of the American Veterinary Medical Association, 1997, Aug-01, Volume: 211, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Combined Modality Therapy; Forelimb; Gentamicins; Horse Diseases; Ho

1997
Etiology and antimicrobial therapy of acute maxillary sinusitis.
    The Journal of infectious diseases, 1979, Volume: 139, Issue:2

    Topics: Adult; Amoxicillin; Ampicillin; Anti-Bacterial Agents; Bacteria; Haemophilus Infections; Haemophilus

1979
Use of trimethoprim-sulfamethoxazole in external otitis.
    Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No

    Topics: Administration, Oral; Administration, Topical; Adolescent; Adult; Anti-Inflammatory Agents; Bacitrac

1975
Chemotherapy of acute bone and joint infections.
    International surgery, 1977, Volume: 62, Issue:3

    Topics: Acute Disease; Adolescent; Adult; Anti-Bacterial Agents; Arthritis, Infectious; Bacterial Infections

1977
Evaluation of sulfamethoxazole-trimethoprim blood agar plates for recovery of group A streptocci from throat cultures.
    Journal of clinical microbiology, 1979, Volume: 9, Issue:2

    Topics: Adolescent; Agar; Blood; Child; Child, Preschool; Diagnosis, Differential; Humans; Pharynx; Streptoc

1979
Comparison of media and techniques for detection of group A streptococci in throat swab specimens.
    Journal of clinical microbiology, 1979, Volume: 9, Issue:2

    Topics: Aerobiosis; Agar; Anaerobiosis; Blood; Diagnosis, Differential; Humans; Pharynx; Streptococcal Infec

1979
Intravenous trimethoprim-sulfamethoxazole in the treatment of serious infections in children.
    The Journal of pediatrics, 1979, Volume: 95, Issue:5 Pt 1

    Topics: Adolescent; Bacterial Infections; Child; Child, Preschool; Drug Therapy, Combination; Escherichia co

1979
Prophylactic chemotherapy with low-dosage trimethoprim-sulfamethoxazole following acute urinary tract infections in children.
    Canadian Medical Association journal, 1975, Jun-14, Volume: 112, Issue:13 Spec No

    Topics: Ampicillin; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Esche

1975
The effects of chemotherapeutics on the species streptococcus in vitro.
    Journal of hygiene, epidemiology, microbiology, and immunology, 1975, Volume: 19, Issue:3

    Topics: Anti-Bacterial Agents; Clindamycin; Dose-Response Relationship, Drug; Doxycycline; Floxacillin; Micr

1975
Antibiotic treatment of enterococcal infection.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:12

    Topics: Humans; Streptococcal Infections; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination; Uri

1989
Enterococci and antifolate antibiotics.
    European journal of clinical microbiology, 1986, Volume: 5, Issue:4

    Topics: Drug Combinations; Drug Synergism; Enterococcus faecalis; Humans; Microbial Sensitivity Tests; Strep

1986
[The frequency of group A beta-hemolytic Streptococcus in acute tonsillopharyngitis and therapy with cefadroxil, clavulanic acid-amoxicillin combination and erythromycin in patients unresponsive to procaine penicillin therapy].
    Mikrobiyoloji bulteni, 1987, Volume: 21, Issue:3

    Topics: Acute Disease; Adolescent; Anti-Bacterial Agents; Cefadroxil; Child; Child, Preschool; Drug Combinat

1987
[Treatment of infectious endocarditis with trimethoprim-sulfamethoxazole and cardiac surgery].
    Mikrobiyoloji bulteni, 1986, Volume: 20, Issue:3

    Topics: Child; Combined Modality Therapy; Drug Combinations; Endocarditis, Bacterial; Humans; Male; Mitral V

1986
[Antibiotic resistance and serotypes of Streptococcus pneumoniae in Zurich (1984-1985)].
    Schweizerische medizinische Wochenschrift, 1987, Jun-06, Volume: 117, Issue:23

    Topics: Amoxicillin; Anti-Bacterial Agents; Cefaclor; Erythromycin; Humans; Microbial Sensitivity Tests; Pen

1987
Streptococcal meningitis in pigs: field trial to study the prophylactic effect of trimethoprim/sulphadiazine medication in feed.
    The Veterinary record, 1986, Oct-18, Volume: 119, Issue:16

    Topics: Animal Feed; Animals; Female; Male; Meningitis; Streptococcal Infections; Sulfadiazine; Swine; Swine

1986
Pneumococcal carriage amongst Australian aborigines in Alice Springs, Northern Territory.
    The Journal of hygiene, 1985, Volume: 95, Issue:3

    Topics: Adolescent; Adult; Age Factors; Aged; Anti-Bacterial Agents; Australia; Bacterial Vaccines; Carrier

1985
Trimethoprim and methenamine hippurate. A new theoretical combination for the treatment of urinary tract infections.
    Scandinavian journal of infectious diseases, 1985, Volume: 17, Issue:2

    Topics: Adult; Drug Resistance, Microbial; Drug Synergism; Drug Therapy, Combination; Escherichia coli Infec

1985
Streptococcal meningitis in pigs: field trial to compare the effects of two different treatments.
    The Veterinary record, 1985, Jul-20, Volume: 117, Issue:3

    Topics: Animals; Drug Combinations; Female; Male; Meningitis; Penicillins; Streptococcal Infections; Sulfadi

1985
Trimethoprim sulfamethoxazole therapy of chronic bacterial prostatitis.
    The Journal of urology, 1974, Volume: 111, Issue:5

    Topics: Adolescent; Adult; Aged; Bacterial Infections; Candidiasis, Oral; Child; Drug Eruptions; Escherichia

1974
[Trimethoprim-sulfamethoxazole association in the treatment of some infectious diseases. Preliminary results].
    Minerva medica, 1974, Oct-10, Volume: 65, Issue:71

    Topics: Adolescent; Adult; Bacterial Infections; Brucellosis; Child; Child, Preschool; Drug Combinations; Dr

1974
Trimethoprim-sulphamethoxazole in urinary tract infection due to Streptococcus faecalis.
    Journal of clinical pathology, 1972, Volume: 25, Issue:6

    Topics: Ampicillin; Anti-Bacterial Agents; Enterococcus faecalis; Folic Acid Antagonists; Humans; Microbial

1972
[Biseptolin in the treatment of streptococcal infections].
    Wiadomosci lekarskie (Warsaw, Poland : 1960), 1973, Aug-01, Volume: 26, Issue:15

    Topics: Acute Disease; Adult; Anti-Infective Agents; Evaluation Studies as Topic; Folic Acid Antagonists; Hu

1973
Trimethoprim-sulfamethoxazole in the treatment of bacterial endocarditis.
    The Journal of infectious diseases, 1973, Volume: 128

    Topics: Adolescent; Adult; Aged; Child; Drug Combinations; Endocarditis, Bacterial; Female; Humans; Male; Mi

1973
An improved synthesis of diaveridine, trimethoprim, and closely related 2,4-diaminopyrimidines.
    Journal of medicinal chemistry, 1971, Volume: 14, Issue:5

    Topics: Administration, Oral; Animals; Anti-Infective Agents; Drug Synergism; Escherichia coli Infections; K

1971
[Experiences with trimethoprim-sulfamethoxazole in the chemotherapy of bacterial infections].
    Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete, 1970, Aug-15, Volume: 25, Issue:16

    Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Bacterial Infections; Bacteriuria; Bronchiectasis; B

1970
[Antibacterial activity in vitro and in vivo of the trimethoprim-sulphamethoxazole combination].
    Antibiotica, 1969, Volume: 7, Issue:4

    Topics: Animals; Anti-Bacterial Agents; Drug Combinations; Drug Resistance, Microbial; Escherichia coli; Fol

1969
[Comparative clinical and bacteriological studies of trimethoprim-sulfamethoxazole and ampicillin in pediatrics].
    Padiatrie und Padologie, 1972, Volume: 7, Issue:4

    Topics: Ampicillin; Anti-Infective Agents; Child; Child, Preschool; Drug Combinations; Evaluation Studies as

1972