trimethoprim has been researched along with Stevens-Johnson Syndrome in 37 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Stevens-Johnson Syndrome: Rare cutaneous eruption characterized by extensive KERATINOCYTE apoptosis resulting in skin detachment with mucosal involvement. It is often provoked by the use of drugs (e.g., antibiotics and anticonvulsants) or associated with PNEUMONIA, MYCOPLASMA. It is considered a continuum of Toxic Epidermal Necrolysis.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trimethoprim is the antibiotic of choice for treating uncomplicated community acquired urinary tract infections." | 3.73 | Fatal adverse drug reaction to trimethoprim. ( Bermingham, MR; Chapple, SJ; Mortimer, NJ; Sladden, MJ, 2005) |
| "Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare, severe mucocutaneous reaction with few large cohorts reported." | 1.48 | Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States. ( Agarwal, A; Aleshin, M; Boggs, J; Cardones, AR; Chen, JK; Chiesa-Fuxench, Z; Cotliar, J; Davis, MDP; Dominguez, A; Fox, LP; Gelfand, JM; Gordon, S; Hamrick, R; Ho, B; Hughey, LC; John, JS; Jones, LM; Kaffenberger, BH; Kindley, K; Kroshinsky, D; Kwong, BY; Margolis, DJ; Micheletti, RG; Miller, DD; Mostaghimi, A; Musiek, A; Noe, MH; Ortega-Loayza, AG; Patel, R; Posligua, A; Rani, M; Rosenbach, M; Saluja, S; Sharon, VR; Shinkai, K; Stephen, S; Strickland, N; Summers, EM; Sun, N; Wanat, KA; Wetter, DA; Worswick, S; Yang, C, 2018) |
| "To report a case of toxic epidermal necrolysis (TEN) associated with trimethoprim/sulfamethoxazole (TMP/SMX)." | 1.31 | Trimethoprim/sulfamethoxazole-induced toxic epidermal necrolysis. ( Mumford, JM; See, S, 2001) |
| "Silver nitrate was selected over silver sulfadiazine (Silvadene) and mafenide in view of the nature of the offending agent." | 1.26 | Toxic epidermal necrolysis-case report and review of the literature. ( Horn, MS; Ortiz, JE; Peterson, HD, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 27 (72.97) | 18.7374 |
| 1990's | 2 (5.41) | 18.2507 |
| 2000's | 3 (8.11) | 29.6817 |
| 2010's | 4 (10.81) | 24.3611 |
| 2020's | 1 (2.70) | 2.80 |
| Authors | Studies |
|---|---|
| Shanbhag, SS | 1 |
| Shih, G | 1 |
| Bispo, PJM | 1 |
| Chodosh, J | 1 |
| Jacobs, DS | 1 |
| Saeed, HN | 1 |
| Micheletti, RG | 1 |
| Chiesa-Fuxench, Z | 1 |
| Noe, MH | 1 |
| Stephen, S | 1 |
| Aleshin, M | 1 |
| Agarwal, A | 1 |
| Boggs, J | 1 |
| Cardones, AR | 1 |
| Chen, JK | 1 |
| Cotliar, J | 1 |
| Davis, MDP | 1 |
| Dominguez, A | 1 |
| Fox, LP | 1 |
| Gordon, S | 1 |
| Hamrick, R | 1 |
| Ho, B | 1 |
| Hughey, LC | 1 |
| Jones, LM | 1 |
| Kaffenberger, BH | 1 |
| Kindley, K | 1 |
| Kroshinsky, D | 1 |
| Kwong, BY | 1 |
| Miller, DD | 1 |
| Mostaghimi, A | 1 |
| Musiek, A | 1 |
| Ortega-Loayza, AG | 1 |
| Patel, R | 1 |
| Posligua, A | 1 |
| Rani, M | 1 |
| Saluja, S | 1 |
| Sharon, VR | 1 |
| Shinkai, K | 1 |
| John, JS | 1 |
| Strickland, N | 1 |
| Summers, EM | 1 |
| Sun, N | 1 |
| Wanat, KA | 1 |
| Wetter, DA | 1 |
| Worswick, S | 1 |
| Yang, C | 1 |
| Margolis, DJ | 1 |
| Gelfand, JM | 1 |
| Rosenbach, M | 1 |
| Potocnik, E | 1 |
| Drozdzewska, K | 1 |
| Schwarz, B | 1 |
| Reese, D | 1 |
| Henning, JS | 2 |
| Rockers, K | 1 |
| Ladd, D | 1 |
| Gilson, R | 1 |
| Firoz, BF | 1 |
| Zarzabal, LA | 1 |
| Pollock, BH | 1 |
| Nomura, T | 1 |
| Abe, R | 1 |
| Fujimoto, K | 1 |
| Endo, T | 1 |
| Shimizu, H | 1 |
| Koike, T | 1 |
| Mortimer, NJ | 1 |
| Bermingham, MR | 1 |
| Chapple, SJ | 1 |
| Sladden, MJ | 1 |
| Kauppinen, K | 1 |
| Stubb, S | 1 |
| Nagy, G | 1 |
| Meszáros, A | 1 |
| Fong, PH | 1 |
| Ratnagopal, P | 1 |
| Wong, KL | 1 |
| Petersen, P | 1 |
| Kastrup, J | 1 |
| Bartram, R | 1 |
| Brettle, RP | 1 |
| Gray, JA | 1 |
| Sangster, G | 1 |
| Murdoch, JM | 1 |
| Dick, HM | 1 |
| Ortiz, JE | 1 |
| Horn, MS | 1 |
| Peterson, HD | 1 |
| Klein, CE | 1 |
| Trautmann, A | 1 |
| Zillikens, D | 1 |
| Bröcker, EB | 1 |
| Arola, O | 1 |
| Peltonen, R | 1 |
| Rossi, T | 1 |
| See, S | 1 |
| Mumford, JM | 1 |
| Thorpe, JA | 1 |
| Nysenbaum, A | 1 |
| Kikuchi, S | 1 |
| Okazaki, T | 1 |
| Richmond, JM | 1 |
| Whitworth, JA | 1 |
| Fairley, KF | 1 |
| Kincaid-Smith, P | 1 |
| Kostrzewa, J | 1 |
| Pawłowska, EM | 1 |
| Petricević, I | 1 |
| Tomljenović, V | 1 |
| Soldo, I | 1 |
| Caumes, E | 1 |
| Feyeux, C | 1 |
| Garrouste, MT | 1 |
| Schlemmer, B | 1 |
| Wallach, D | 1 |
| Whittington, RM | 1 |
| Carmichael, AJ | 1 |
| Tan, CY | 1 |
| Born, TE | 1 |
| Zawada, ET | 1 |
| Romeu, J | 1 |
| Clotet, B | 1 |
| Tural, C | 1 |
| Carles, J | 1 |
| Foz, M | 1 |
| Schöpf, E | 1 |
| Nwokolo, C | 1 |
| Byrne, L | 1 |
| Misch, KJ | 1 |
| Das, G | 1 |
| Bailey, MJ | 1 |
| Wickham, JE | 1 |
| Baird, BJ | 1 |
| De Villez, RL | 1 |
| Roujeau, JC | 1 |
| Albengres, E | 1 |
| Moritz, S | 1 |
| Piacentino, A | 1 |
| Cuny, M | 1 |
| Revuz, J | 1 |
| Touraine, R | 1 |
| Avery, JK | 1 |
| Schulz, KH | 1 |
| Lalla, M | 1 |
| Virolainen, M | 1 |
| Chanial, G | 2 |
| Gayet, J | 2 |
| Campagni, JP | 2 |
| Gallet, M | 2 |
| Hugues, M | 2 |
| Barnay, C | 1 |
1 review available for trimethoprim and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Cyclosporine for SJS/TEN: a case series and review of the literature.
Topics: Acetaminophen; Adult; Analgesics, Non-Narcotic; Anti-Infective Agents; Anticonvulsants; Cyclosporine | 2011 |
36 other studies available for trimethoprim and Stevens-Johnson Syndrome
| Article | Year |
|---|---|
Diphtheroids as Corneal Pathogens in Chronic Ocular Surface Disease in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
Topics: Adult; Aged; Anti-Bacterial Agents; Chronic Disease; Corneal Ulcer; Corynebacterium; Corynebacterium | 2021 |
Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: A Multicenter Retrospective Study of 377 Adult Patients from the United States.
Topics: Adrenal Cortex Hormones; Adult; Aged; Cohort Studies; Critical Care; Female; Humans; Immunoglobulins | 2018 |
Presumed Sulfonamide-Associated Uveitis With Stevens-Johnson Syndrome in a Quarter Horse Mare.
Topics: Acinetobacter; Animals; Female; Horse Diseases; Horses; Stevens-Johnson Syndrome; Sulfanilamide; Sul | 2019 |
Toxic epidermal necrolysis: five years of treatment experience from a burn unit.
Topics: Adult; Aged; Allopurinol; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antimetabolites; | 2012 |
Plasma exchange; a promising treatment for toxic epidermal necrolysis with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Anti-HIV Agents; A | 2004 |
Fatal adverse drug reaction to trimethoprim.
Topics: Aged; Anti-Infective Agents, Urinary; Drug Hypersensitivity; Fatal Outcome; Humans; Male; Stevens-Jo | 2005 |
Drug eruptions: causative agents and clinical types. A series of in-patients during a 10-year period.
Topics: Ampicillin; Anti-Bacterial Agents; Barbiturates; Drug Eruptions; Humans; Penicillins; Stevens-Johnso | 1984 |
[Acetylsalicylic acid intolerance in Lyell syndrome].
Topics: Aspirin; Drug Combinations; Drug Eruptions; Female; Humans; Middle Aged; Respiratory Tract Infection | 1984 |
Drug induced toxic epidermal necrolysis.
Topics: Adult; Allopurinol; Burns; Critical Care; Drug Combinations; Emergencies; Female; Humans; Middle Age | 1984 |
[Toxic epidermal necrolysis. A case caused by sulphamethoxazole combined with trimethoprim].
Topics: Anti-Infective Agents, Urinary; Drug Combinations; Humans; Male; Middle Aged; Stevens-Johnson Syndro | 1983 |
The mucocutaneous syndromes--Erythema multiforme, Stevens-Johnson and Ectodermosis erosiva pluriorificialis.
Topics: Adolescent; Adult; Aged; Bacterial Infections; Child; Child, Preschool; Drug Combinations; Erythema | 1982 |
Toxic epidermal necrolysis-case report and review of the literature.
Topics: Adult; Drug Therapy, Combination; Humans; Male; Resuscitation; Silver Nitrate; Stevens-Johnson Syndr | 1982 |
Patch testing in an unusual case of toxic epidermal necrolysis.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents, Urinary; Diagnosis, Differential; Humans; Male; Patc | 1995 |
Arthritis, uveitis, and Stevens-Johnson syndrome induced by trimethoprim.
Topics: Adult; Anti-Infective Agents, Urinary; Arthritis; Female; Humans; Stevens-Johnson Syndrome; Trimetho | 1998 |
Trimethoprim/sulfamethoxazole-induced toxic epidermal necrolysis.
Topics: Adult; Drug Combinations; Female; Humans; Stevens-Johnson Syndrome; Sulfamethizole; Trimethoprim; Ur | 2001 |
Co-trimoxazole fatality.
Topics: Drug Combinations; Female; Humans; Middle Aged; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimetho | 1978 |
Stevens-Johnson syndrome due to co-trimoxazole.
Topics: Adult; Drug Combinations; Female; Humans; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim | 1978 |
Co-trimoxazole nephrotoxicity.
Topics: Acute Kidney Injury; Drug Combinations; Drug Hypersensitivity; Erythema; Humans; Kidney; Stevens-Joh | 1979 |
Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-1978.
Topics: Adult; Diagnosis, Differential; Female; Humans; Lupus Erythematosus, Systemic; Skin; Stevens-Johnson | 1978 |
[Case of severe Stevens-Johnson syndrome following administration of Biseptol 480].
Topics: Drug Combinations; Humans; Male; Middle Aged; Stevens-Johnson Syndrome; Sulfamoxole; Trimethoprim | 1978 |
[Lyell's disease. Report of a case (author's transl)].
Topics: Aged; Drug Combinations; Humans; Male; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim | 1978 |
[Bullous toxic skin disease with fatal outcome in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Humans; Male; Middle Aged; Prognosis; Pyrimethamine; Stevens-Joh | 1989 |
Toxic epidermal necrolysis and co-trimoxazole.
Topics: Aged; Aged, 80 and over; Anti-Infective Agents; Bronchitis; Drug Combinations; Humans; Male; Postope | 1989 |
Fatal toxic epidermal necrolysis associated with co-trimoxazole.
Topics: Aged; Drug Combinations; Humans; Stevens-Johnson Syndrome; Sulfamethoxazole; Trimethoprim; Trimethop | 1989 |
Toxic epidermal necrolysis: a medical student's perspective.
Topics: Adult; Drug Combinations; Female; Humans; Stevens-Johnson Syndrome; Students, Medical; Sulfamethizol | 1989 |
Therapeutic challenge for Isospora belli enteritis in an AIDS patient who developed Lyell syndrome after co-trimoxazole therapy.
Topics: Acquired Immunodeficiency Syndrome; Adult; Coccidiosis; Drug Combinations; Enteritis; Humans; Male; | 1989 |
Skin reactions to co-trimoxazole.
Topics: Anti-Infective Agents; Drug Combinations; Drug Eruptions; Humans; Skin; Stevens-Johnson Syndrome; Su | 1987 |
Toxic epidermal necrolysis occurring during treatment with trimethoprim alone.
Topics: Aged; Female; Humans; Stevens-Johnson Syndrome; Trimethoprim | 1988 |
Toxic epidermal necrolysis and trimethoprim.
Topics: Female; Humans; Stevens-Johnson Syndrome; Trimethoprim; Ureteral Calculi | 1988 |
Widespread bullous fixed drug eruption mimicking toxic epidermal necrolysis.
Topics: Adult; Anti-Infective Agents; Diagnosis, Differential; Drug Combinations; Female; Humans; Male; Phen | 1988 |
Lymphocyte transformation test in drug-induced toxic epidermal necrolysis.
Topics: Adolescent; Adult; Aged; Carbamazepine; Child; Dipyrone; Drug Combinations; Female; Flurbiprofen; Hu | 1985 |
If only I had seen him ...
Topics: Adult; Carbenicillin; Drug Combinations; Humans; Male; Malpractice; Prostatitis; Staphylococcal Infe | 1985 |
[Lymphocyte transformation test in drug hypersensitivity].
Topics: Ampicillin; Drug Hypersensitivity; Exanthema; Humans; Immunologic Techniques; Lymphocyte Activation; | 1972 |
Blood lymphoblast proliferation in vivo in cutaneous drug hypersensitivity reactions.
Topics: Blood Cell Count; Carbamazepine; Chlorpromazine; Drug Hypersensitivity; Exanthema; Humans; Lymphocyt | 1974 |
[Lyell's syndrome in the 2nd month of viral hepatitis after administration of sulfamethoxazole-trimethoprim; associated cardiac rhythm disorders].
Topics: Aged; Anti-Infective Agents; Arrhythmias, Cardiac; Electrocardiography; Female; Folic Acid Antagonis | 1972 |
[Lyell's syndrome in the 2d month of a viral hepatitis following ingestion of sulfamethoxazole-trimethoprime; associated heart rhythm disorders].
Topics: Aged; Anti-Infective Agents; Arrhythmias, Cardiac; Bradycardia; Drug Combinations; Female; Heart Blo | 1971 |