trimethoprim has been researched along with Sensitivity and Specificity in 29 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "A simple, precise, and reliable chromatographic method was developed for the simultaneous determination in plasma and infected tissue of five antimicrobials proposed for the treatment of actinomycotic mycetoma: amoxicillin, trimethoprim, linezolid, sulfamethoxazole and garenoxacin." | 3.74 | Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection. ( Cavazos-Rocha, N; de la Luz Salazar-Cavazos, M; Vera-Cabrera, L; Waksman-de-Torres, N; Welsh-Lozano, O, 2007) |
| " the LTA by using trypan blue exclusion and to determine the utility of the assay to confirm drug hypersensitivity syndrome (DHS) to sulphonamides (SMX) and aromatic anticonvulsants." | 3.70 | A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes. ( Malkiewicz, IM; Neuman, MG; Shear, NH, 2000) |
| "A rapid and sensitive liquid chromatography-tandem mass spectrometric method (LC/MS/MS) for the determination of tetrandrine in rat plasma has been developed, fully validated and successfully applied to pharmacokinetic study in Sprague-Dawley (SD) rats after a single oral administration." | 1.35 | Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study. ( Li, Q; Liu, C; Song, N; Zhang, S, 2008) |
| " The present LC method was successfully applied to the pharmacokinetic studies of coformulated cefalexin dispersible tablets after oral administration to beagle dogs." | 1.33 | Liquid chromatographic method for the simultaneous determination of cefalexin and trimethoprim in dog plasma and application to the pharmacokinetic studies of a coformulated preparation. ( Liu, X; Qi, M; Sun, P; Wang, P, 2006) |
| "Treatment with sulfamethoxazole-trimethoprim for three days was compared with daily prophylaxis with sulfamethoxazole-trimethoprim or doxycycline." | 1.27 | A cost-effectiveness comparison of the use of antimicrobial agents for treatment or prophylaxis of travelers' diarrhea. ( DuPont, HL; Ericsson, CD; Johnson, PC; Reves, RR, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (3.45) | 18.7374 |
| 1990's | 4 (13.79) | 18.2507 |
| 2000's | 18 (62.07) | 29.6817 |
| 2010's | 6 (20.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Kim, DH | 1 |
| Kim, H | 1 |
| Chon, JW | 1 |
| Moon, JS | 1 |
| Song, KY | 1 |
| Seo, KH | 1 |
| Martins, MT | 1 |
| Melo, J | 1 |
| Barreto, F | 1 |
| Hoff, RB | 1 |
| Jank, L | 1 |
| Bittencourt, MS | 1 |
| Arsand, JB | 1 |
| Schapoval, EE | 1 |
| Sellmyer, MA | 1 |
| Lee, I | 1 |
| Hou, C | 1 |
| Lieberman, BP | 1 |
| Zeng, C | 1 |
| Mankoff, DA | 1 |
| Mach, RH | 1 |
| Song, N | 1 |
| Zhang, S | 1 |
| Li, Q | 1 |
| Liu, C | 1 |
| Shewiyo, DH | 1 |
| Kaale, E | 1 |
| Risha, PG | 1 |
| Dejaegher, B | 1 |
| Smeyers-Verbeke, J | 1 |
| Vander Heyden, Y | 2 |
| Leblanc, A | 1 |
| Shiao, TC | 1 |
| Roy, R | 1 |
| Sleno, L | 1 |
| Wombacher, R | 1 |
| Heidbreder, M | 1 |
| van de Linde, S | 1 |
| Sheetz, MP | 1 |
| Heilemann, M | 1 |
| Cornish, VW | 1 |
| Sauer, M | 1 |
| Ftayeh, RM | 1 |
| von Tiedemann, A | 1 |
| Rudolph, KW | 1 |
| Demirkaya, O | 1 |
| Althaus, RL | 1 |
| Torres, A | 1 |
| Montero, A | 1 |
| Balasch, S | 1 |
| Molina, MP | 1 |
| Teshima, D | 1 |
| Otsubo, K | 1 |
| Makino, K | 1 |
| Itoh, Y | 1 |
| Oishi, R | 1 |
| Göbel, A | 1 |
| McArdell, CS | 2 |
| Suter, MJ | 2 |
| Giger, W | 1 |
| Berzas Nevado, JJ | 1 |
| Castañeda Peñalvo, G | 1 |
| Guzmán Bernardo, FJ | 1 |
| Kovarik, P | 1 |
| Hodgson, RJ | 1 |
| Covey, T | 1 |
| Brook, MA | 1 |
| Brennan, JD | 1 |
| Pereira, AV | 1 |
| Cass, QB | 1 |
| Qi, M | 1 |
| Wang, P | 1 |
| Sun, P | 1 |
| Liu, X | 1 |
| Cavazos-Rocha, N | 1 |
| Vera-Cabrera, L | 1 |
| Welsh-Lozano, O | 1 |
| Waksman-de-Torres, N | 1 |
| de la Luz Salazar-Cavazos, M | 1 |
| Romero-González, R | 1 |
| López-Martínez, JC | 1 |
| Gómez-Milán, E | 1 |
| Garrido-Frenich, A | 1 |
| Martínez-Vidal, JL | 1 |
| Qu, QS | 1 |
| Mangelings, D | 1 |
| Shen, F | 1 |
| Hu, XY | 1 |
| Yan, C | 1 |
| Zhang, YK | 1 |
| McClure, EL | 1 |
| Wong, CS | 1 |
| Baccanari, DP | 1 |
| Kuyper, LF | 1 |
| Grant, AN | 1 |
| Laidler, LA | 1 |
| Widdowson, CA | 1 |
| Klugman, KP | 1 |
| Neuman, MG | 1 |
| Malkiewicz, IM | 1 |
| Shear, NH | 1 |
| Batzias, GC | 1 |
| Botsoglou, NA | 1 |
| Kotsaki-Kovatsi, VP | 1 |
| Kounenis, G | 1 |
| Haller, MY | 1 |
| Müller, SR | 1 |
| Alder, AC | 1 |
| Chen, Y | 1 |
| Potter, JM | 1 |
| Ravenscroft, PJ | 1 |
| Reves, RR | 1 |
| Johnson, PC | 1 |
| Ericsson, CD | 1 |
| DuPont, HL | 1 |
2 reviews available for trimethoprim and Sensitivity and Specificity
| Article | Year |
|---|---|
Basis of selectivity of antibacterial diaminopyrimidines.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Humans; Mice; NADP; Protein Conformation; Py | 1993 |
Molecular mechanisms of resistance to commonly used non-betalactam drugs in Streptococcus pneumoniae.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Cats; Drug Resistance, Multiple; Erythromycin | 1999 |
27 other studies available for trimethoprim and Sensitivity and Specificity
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Development of blood-yolk-polymyxin B-trimethoprim agar for the enumeration of Bacillus cereus in various foods.
Topics: Agar; Animals; Bacillus cereus; Bacterial Load; Culture Media; Egg Yolk; Food Microbiology; Polymyxi | 2013 |
A simple, fast and cheap non-SPE screening method for antibacterial residue analysis in milk and liver using liquid chromatography-tandem mass spectrometry.
Topics: Animals; Anti-Bacterial Agents; Cattle; Chromatography, Liquid; Drug Residues; Ethanol; Fluoroquinol | 2014 |
Quantitative PET Reporter Gene Imaging with [
Topics: Animals; Carbon Radioisotopes; Cell Line; Genes, Reporter; Mice; Molecular Imaging; Positron-Emissio | 2017 |
Establishment of a liquid chromatographic/mass spectrometry method for quantification of tetrandrine in rat plasma and its application to pharmacokinetic study.
Topics: Animals; Area Under Curve; Benzylisoquinolines; Calibration; Chromatography, Liquid; Drug Stability; | 2008 |
Development and validation of a normal-phase high-performance thin layer chromatographic method for the analysis of sulfamethoxazole and trimethoprim in co-trimoxazole tablets.
Topics: Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Linear Models; Reproducibility of | 2009 |
Improved detection of reactive metabolites with a bromine-containing glutathione analog using mass defect and isotope pattern matching.
Topics: Acetaminophen; Animals; Bromine Compounds; Chromatography, Liquid; Clozapine; Glutathione; Microsome | 2010 |
Live-cell super-resolution imaging with trimethoprim conjugates.
Topics: Cell Survival; HeLa Cells; Histones; Humans; Microscopy, Fluorescence; Sensitivity and Specificity; | 2010 |
A new selective medium for isolation of Clavibacter michiganensis subsp. michiganensis from tomato plants and seed.
Topics: Boric Acids; Culture Media; Micrococcaceae; Nalidixic Acid; Plant Diseases; Polymyxins; Seeds; Sensi | 2011 |
Anisotropic diffusion filtering of PET attenuation data to improve emission images.
Topics: Algorithms; Anisotropy; Artifacts; Drug Combinations; Feedback; Humans; Image Enhancement; Nonlinear | 2002 |
Detection limits of antimicrobials in ewe milk by delvotest photometric measurements.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Anti-Infective Agents; Chloramphenicol; Drug Residu | 2003 |
Simultaneous determination of sulfamethoxazole and trimethoprim in human plasma by capillary zone electrophoresis.
Topics: Electrophoresis, Capillary; Humans; Reference Standards; Reproducibility of Results; Sensitivity and | 2004 |
Trace determination of macrolide and sulfonamide antimicrobials, a human sulfonamide metabolite, and trimethoprim in wastewater using liquid chromatography coupled to electrospray tandem mass spectrometry.
Topics: Macrolides; Medical Waste Disposal; Molecular Conformation; Sensitivity and Specificity; Sulfonamide | 2004 |
Micellar electrokinetic chromatography method for the determination of sulfamethoxazole, trimethoprim and their main metabolites in human serum.
Topics: Anti-Infective Agents; Chromatography, Micellar Electrokinetic Capillary; Humans; Molecular Structur | 2005 |
Capillary-scale frontal affinity chromatography/MALDI tandem mass spectrometry using protein-doped monolithic silica columns.
Topics: Automation; Binding Sites; Buffers; Chromatography, Affinity; Coumaric Acids; Fluorescein; Folic Aci | 2005 |
High-performance liquid chromatography method for the simultaneous determination of sulfamethoxazole and trimethoprim in bovine milk using an on-line clean-up column.
Topics: Animals; Cattle; Chromatography, High Pressure Liquid; Drug Stability; Female; Freezing; Milk; Onlin | 2005 |
Liquid chromatographic method for the simultaneous determination of cefalexin and trimethoprim in dog plasma and application to the pharmacokinetic studies of a coformulated preparation.
Topics: Animals; Anti-Bacterial Agents; Cephalexin; Chromatography, Liquid; Dogs; Drug Combinations; Quality | 2006 |
Simultaneous determination and validation of antimicrobials in plasma and tissue of actinomycetoma by high-performance liquid chromatography with diode array and fluorescence detection.
Topics: Acetamides; Acetonitriles; Amoxicillin; Animals; Anti-Bacterial Agents; Buffers; Chemical Precipitat | 2007 |
Simultaneous determination of selected veterinary antibiotics in gilthead seabream (Sparus Aurata) by liquid chromatography-mass spectrometry.
Topics: Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Drug Residues; Fish Diseases; | 2007 |
Pressurized capillary electrochromatographic assay of trimethoprim impurities using 1 microm particle-based columns.
Topics: Biological Assay; Calibration; Chromatography, Micellar Electrokinetic Capillary; Drug Contamination | 2007 |
Solid phase microextraction of macrolide, trimethoprim, and sulfonamide antibiotics in wastewaters.
Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Dimethylpolysiloxanes; Macrolides; Mole | 2007 |
Assessment of the antimicrobial sensitivity of Aeromonas salmonicida isolates from farmed Atlantic salmon in Scotland.
Topics: Aeromonas; Animals; Anti-Bacterial Agents; Aquaculture; Drug Combinations; Drug Resistance, Microbia | 1993 |
A novel lymphocyte toxicity assay to assess drug hypersensitivity syndromes.
Topics: Adolescent; Adult; Aged; Animals; Anticonvulsants; Carbamazepine; Case-Control Studies; Cell Surviva | 2000 |
New simple liquid chromatographic method for the determination of trimethoprim, sulfadiazine and N4-acetylsulfadiazine in plasma of broilers.
Topics: Animals; Anti-Infective Agents; Chickens; Chromatography, Liquid; Reproducibility of Results; Sensit | 2002 |
Quantification of veterinary antibiotics (sulfonamides and trimethoprim) in animal manure by liquid chromatography-mass spectrometry.
Topics: Animals; Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Feces; Mass Spectrometry; Qual | 2002 |
A quick, sensitive high-performance liquid chromatography assay for monoethylglycinexylidide and lignocaine in serum/plasma using solid-phase extraction.
Topics: Chemistry Techniques, Analytical; Chromatography, High Pressure Liquid; Humans; Lidocaine; Liver Tra | 1992 |
A cost-effectiveness comparison of the use of antimicrobial agents for treatment or prophylaxis of travelers' diarrhea.
Topics: Anti-Bacterial Agents; Chronic Disease; Cost-Benefit Analysis; Diarrhea; Doxycycline; Drug Combinati | 1988 |