trimethoprim has been researched along with Rheumatoid Arthritis in 14 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A 61-year-old patient with rheumatoid arthritis receiving treatment with methotrexate developed bone marrow hypoplasia after treatment with trimethoprim-sulfamethoxazole." | 3.67 | Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole. ( Gutterman, LA; Thomas, MH, 1986) |
| "Trimethoprim seems not to be a safe form of therapy in patients with a megaloblastic process; many of the toxic reactions reported with this drug may be on the basis of an unrecognized megaloblastic form of haemopoiesis." | 1.25 | Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis. ( Chanarin, I; England, JM, 1972) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (64.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Knuckley, B | 1 |
| Luo, Y | 1 |
| Thompson, PR | 1 |
| Saravana, S | 1 |
| Lalukotta, K | 1 |
| Sathi, N | 1 |
| Dawson, J | 1 |
| Gordon, DL | 1 |
| Philpot, CR | 1 |
| McGuire, C | 1 |
| Steuer, A | 1 |
| Gumpel, JM | 1 |
| Wilson, C | 1 |
| Senior, BW | 1 |
| Tiwana, H | 1 |
| Caparros-Wanderley, W | 1 |
| Ebringer, A | 1 |
| Nair, SR | 1 |
| Karthikeyan, GS | 1 |
| Cherubin, CE | 1 |
| Wallace, SL | 1 |
| Grennan, DM | 1 |
| Bell, G | 1 |
| Rooney, PJ | 1 |
| Kennedy, AC | 1 |
| Thevenet, JP | 1 |
| Ristori, JM | 1 |
| Cure, H | 1 |
| Mizony, MH | 1 |
| Bussiere, JL | 1 |
| Davis, RE | 1 |
| Astbury, C | 1 |
| Hill, J | 1 |
| Bird, HA | 1 |
| Thomas, MH | 1 |
| Gutterman, LA | 1 |
| Kalliomaki, JL | 1 |
| Chanarin, I | 1 |
| England, JM | 1 |
1 review available for trimethoprim and Rheumatoid Arthritis
| Article | Year |
|---|---|
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
2 trials available for trimethoprim and Rheumatoid Arthritis
| Article | Year |
|---|---|
Co-trimoxazole in rheumatoid arthritis: a comparison with sulphapyridine.
Topics: Arthritis, Rheumatoid; Clinical Trials as Topic; Drug Combinations; Humans; Sulfamethoxazole; Sulfap | 1988 |
A therapeutic trial with a combination of trimethoprim-sulphamethoxazole in rheumatoid arthritis.
Topics: Adult; Anti-Infective Agents; Arthritis, Rheumatoid; Blood Sedimentation; Clinical Trials as Topic; | 1972 |
11 other studies available for trimethoprim and Rheumatoid Arthritis
| Article | Year |
|---|---|
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors.
Topics: Arthritis, Rheumatoid; Chlortetracycline; Combinatorial Chemistry Techniques; Enzyme Inhibitors; Flu | 2008 |
Myelotoxicity due to methotrexate - an iatrogenic cause.
Topics: Aged; Anti-Infective Agents, Urinary; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Interactions | 2003 |
Methotrexate-induced pancytopenia associated with co-prescription of penicillin and trimethoprim.
Topics: Anti-Infective Agents; Antirheumatic Agents; Arthritis, Rheumatoid; Drug Prescriptions; Humans; Medi | 2007 |
Plesiomonas shigelloides septic arthritis complicating rheumatoid arthritis.
Topics: Aged; Arthritis, Infectious; Arthritis, Rheumatoid; Bacterial Infections; Drug Combinations; Humans; | 1983 |
Methotrexate and trimethoprim: a fatal interaction.
Topics: Aged; Arthritis, Rheumatoid; Drug Interactions; Fatal Outcome; Female; Humans; Methotrexate; Trimeth | 1998 |
Antibiotic sensitivity and proticine typing of Proteus mirabilis strains associated with rheumatoid arthritis.
Topics: Adult; Aged; Anti-Bacterial Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Arthritis | 1998 |
Medical treatment of Serratia arthritis with trimethoprim-sulfamethoxazole.
Topics: Arthritis, Infectious; Arthritis, Rheumatoid; Drug Combinations; Enterobacteriaceae Infections; Fema | 1978 |
SLE precipitated by antibiotics in a patient with Sjøgren's syndrome and rheumatoid arthritis.
Topics: Adult; Anti-Bacterial Agents; Arthritis, Rheumatoid; Female; Humans; Lupus Erythematosus, Systemic; | 1975 |
[Pancytopenia during treatment of rheumatoid arthritis with methotrexate after administration of trimethoprim-sulfamethoxazole].
Topics: Anti-Infective Agents; Arthritis, Rheumatoid; Drug Combinations; Drug Synergism; Drug Therapy, Combi | 1987 |
Methotrexate toxicity in a patient receiving trimethoprim-sulfamethoxazole.
Topics: Arthritis, Rheumatoid; Bone Marrow Diseases; Drug Combinations; Drug Interactions; Female; Humans; M | 1986 |
Toxicity of trimethoprim-sulphamethoxazole in patients with megaloblastic haemopoiesis.
Topics: Adult; Aged; Agranulocytosis; Anemia, Macrocytic; Anemia, Pernicious; Anti-Infective Agents; Arthrit | 1972 |