trimethoprim has been researched along with Pregnancy in 126 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Sixty consecutive pregnant women with asymptomatic (covert) bacteriuria detected between 16 and 30 weeks gestation were randomly allocated to treatment with either a single 600 mg dose or a standard five-day course of trimethoprim." | 9.06 | Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy. ( Bailey, RR; Bishop, V; Peddie, BA, 1986) |
| "Data available on the fetal safety of trimethoprim-sulfamethoxazole (TMP-SMX) exposure during pregnancy remains scarce and inconclusive." | 7.88 | Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study. ( Bérard, A; Muanda, FT; Sheehy, O, 2018) |
| "Malformations linked to folic acid depletion following exposure during the 3 months before pregnancy." | 7.83 | Trimethoprim during the 3 months before pregnancy: malformations in children. ( , 2016) |
| "38, respectively] if their mothers had a trimethoprim prescription in the 3 months before pregnancy and subtypes of CM for example in the musculoskeletal system, which were consistent to the previous findings from a cohort study." | 7.80 | Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design. ( Olsen, J; Sun, Y; Wu, CS, 2014) |
| "Ofloxacin appears to be an appropriate antibiotic for short term therapy of acute, uncomplicated, lower urinary tract infections, comparing favourably with trimethoprim-sulphamethoxazole treatment in this study." | 6.66 | Ofloxacin versus trimethoprim-sulphamethoxazole in acute cystitis. ( Bjertnaes, A; Block, JM; Hafstad, PE; Holte, M; Ottemo, I; Peterson, LE; Rolstad, T; Svarva, PL; Walstad, RA, 1987) |
| "The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2∙04 (95% confidence interval 1∙43-2∙91)." | 5.39 | Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. ( Afzal, S; Andersen, EW; Andersen, JT; Andersen, NL; Broedbaek, K; Jimenez-Solem, E; Keiding, N; Petersen, M; Poulsen, HE; Torp-Pedersen, C, 2013) |
| " There are no consequences concerning the dosage of Berlocombin in bacterial infections during pregnancy." | 5.26 | [Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy]. ( Müller, B; Nöschel, H; Peiker, G; Pischke, U; Schröder, S; Traeger, A, 1982) |
| "Our exploratory analyses support the hypothesis that IRS may significantly reduce malaria and preterm birth risk among pregnant women with HIV receiving bed nets, daily trimethoprim-sulfamethoxazole, and combination antiretroviral therapy." | 5.24 | Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis. ( Awori, P; Clark, TD; Cohan, D; Dorsey, G; Gosling, R; Havlir, DV; Jagannathan, P; Kakuru, A; Kamya, MR; Koss, CA; Muhindo, M; Nakalambe, M; Natureeba, P; Ochieng, T; Plenty, A; Roh, ME; Shiboski, S, 2017) |
| "Intermittent preventive treatment in pregnancy with sulfadoxine/pyrimethamine is contra-indicated in HIV-positive pregnant women receiving sulfamethoxazole/trimethoprim prophylaxis." | 5.22 | Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya. ( Desai, M; González, R; Green, M; Kariuki, S; Katana, A; Menendez, C; Otieno, K; Ouma, P; Slutsker, L; ter Kuile, F, 2016) |
| "Sixty consecutive pregnant women with asymptomatic (covert) bacteriuria detected between 16 and 30 weeks gestation were randomly allocated to treatment with either a single 600 mg dose or a standard five-day course of trimethoprim." | 5.06 | Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy. ( Bailey, RR; Bishop, V; Peddie, BA, 1986) |
| "Single-dose trimethoprim-sulfamethoxazole prophylaxis after clamping of the umbilical cord decreased the rate of endomyometritis in high-risk patients by 50% when compared with placebo." | 5.06 | Single-dose trimethoprim-sulfamethoxazole prophylaxis for cesarean section. ( Apuzzio, JJ; Bergen, B; Dispenziere, B; Ganesh, V; Louria, DB; Patel, K, 1986) |
| "Data available on the fetal safety of trimethoprim-sulfamethoxazole (TMP-SMX) exposure during pregnancy remains scarce and inconclusive." | 3.88 | Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study. ( Bérard, A; Muanda, FT; Sheehy, O, 2018) |
| " Adult wild-type (WT) and Cxcr2-/- mice were fed a diet supplemented with sulfamethoxazole/trimethoprim (SMZ/TMP) during pregnancy and lactation, and their pups were injected intraperitoneally with rhesus rotavirus (RRV) within 24 hours of life to induce experimental biliary atresia." | 3.85 | Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia. ( Bezerra, JA; Fei, L; Jee, J; Mourya, R; Shivakumar, P; Wagner, M, 2017) |
| "Ciprofloxacin, ceftriaxone, and sulfamethoxazole/trimethoprim are suitable choices for the treatment of bacterial acute diarrhea." | 3.83 | Characteristics of bacterial acute diarrhea among women. ( Antonello, VS; Dallé, J; Jimenez, MF; Kronbauer, K; Riche, CW; Rocha-Castro, J; Santiago, JA, 2016) |
| "Malformations linked to folic acid depletion following exposure during the 3 months before pregnancy." | 3.83 | Trimethoprim during the 3 months before pregnancy: malformations in children. ( , 2016) |
| "38, respectively] if their mothers had a trimethoprim prescription in the 3 months before pregnancy and subtypes of CM for example in the musculoskeletal system, which were consistent to the previous findings from a cohort study." | 3.80 | Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design. ( Olsen, J; Sun, Y; Wu, CS, 2014) |
| " Pregnancy termination was refused, and she was treated with intravenous ampicillin and gentamicin followed by oral trimethoprim/sulfamethoxazol." | 3.67 | First-trimester maternal Listeria monocytogenes sepsis and chorioamnionitis with normal neonatal outcome. ( Cruikshank, DP; Warenski, JC, 1989) |
| "Trimethoprim recently has been released by the Food and Drug Administration (FDA) exclusively for the treatment of acute symptomatic uncomplicated bacterial urinary tract infections." | 3.66 | Introduction of trimethoprim: a mixed blessing. ( Gleckman, RA, 1981) |
| " Seven women with indications for interruption of pregnancy for social reasons have taken Biseptol 480--Polfa (400 mg sulfamethoxazole and 80 mg trimethoprim) for 4-5 days before the operation." | 3.66 | [Sulfamethoxazole concentration in the homogenate of the human embryo]. ( Prokopczyk, J; Raczyński, A; Troszyński, M; Wańkowicz, B; Wenzel, E, 1979) |
| "The present chemotherapy to treat or prevent toxoplasmosis is deficient and is based on diverse drugs such as atovaquone, trimethoprim, spiramycine, which are effective in acute toxoplasmosis." | 3.01 | An updated review of chemical compounds with anti-Toxoplasma gondii activity. ( Rodriguez, JB; Szajnman, SH, 2023) |
| "Ofloxacin appears to be an appropriate antibiotic for short term therapy of acute, uncomplicated, lower urinary tract infections, comparing favourably with trimethoprim-sulphamethoxazole treatment in this study." | 2.66 | Ofloxacin versus trimethoprim-sulphamethoxazole in acute cystitis. ( Bjertnaes, A; Block, JM; Hafstad, PE; Holte, M; Ottemo, I; Peterson, LE; Rolstad, T; Svarva, PL; Walstad, RA, 1987) |
| " It is believed that traditional dosage regimens for uncomplicated UTIs are extravagant." | 2.38 | Management of lower urinary tract infections. ( Bailey, RR, 1993) |
| "Pneumocystis carinii pneumonia is the most common life-threatening disease diagnosed in patients infected with the human immunodeficiency virus (HIV)." | 2.38 | Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia. ( Sarti, GM, 1989) |
| "Trimethoprim has a lesser propensity to select resistant organisms than most other antimicrobials." | 2.36 | Pharmacological principles in the treatment of urinary tract infections. ( Sommers, DK, 1983) |
| " In the present study, we aimed to develop a pharmacokinetic (PK) model of transplacental transfer of metformin to predict in vivo fetal exposure to metformin and to resolve the apparent inconsistency between open and closed ex vivo systems." | 1.56 | Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure. ( Chiba, K; Kurosawa, K; Nishimura, T; Noguchi, S; Tomi, M, 2020) |
| "The adjusted hazard ratio of having a miscarriage after exposure to trimethoprim in the first trimester compared to non-exposure was 2∙04 (95% confidence interval 1∙43-2∙91)." | 1.39 | Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study. ( Afzal, S; Andersen, EW; Andersen, JT; Andersen, NL; Broedbaek, K; Jimenez-Solem, E; Keiding, N; Petersen, M; Poulsen, HE; Torp-Pedersen, C, 2013) |
| " The pharmacokinetic parameters of SDX showed no significant difference between lactating and pregnant sows (Vss, 0." | 1.29 | Pharmacokinetics of sulphadoxine and trimethoprim in sows: influence of lactation. ( Hellwig, EG; Küng, K; Wanner, M, 1994) |
| "Five drug regimens for the treatment of acute toxoplasmosis were compared in a monkey model." | 1.27 | Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys. ( Harper, JS; London, WT; Sever, JL, 1985) |
| "Tetracycline is an effective drug for management of childhood brucellosis." | 1.27 | Brucellosis in children in Iraq. ( Al-Dubooni, HM; Al-Shirkat, SA; Nagi, NA, 1986) |
| "Ethical and medical problems arise with typhoid infections in pregnant women." | 1.27 | Treatment of typhoid fever in pregnancy. ( Buongiorno, R; Schiraldi, O, 1984) |
| " Sows in five of the groups were dosed with high levels of tiamulin and trimethoprim-sulphonamide preparations from their entry into the farrowing house until their biggest piglets were weaned." | 1.26 | Medicated early weaning to obtain pigs free from pathogens endemic in the herd of origin. ( Alexander, TJ; Boon, G; Gush, AF; Lysons, RJ; Thornton, K, 1980) |
| " The dosage was 1,500, 1,000, 750 and 200 mg trimethoprim per kg bodyweight." | 1.26 | [Investigation on the influence of trimethoprim at the intrauterine development in the rat (author's transl)]. ( Kreutz, R, 1981) |
| " In this dose range the pup weights and the weight gain of the offspring of dams with continued dosing during lactation were also reduced." | 1.26 | [Investigations on the effect of the combination sulfamoxole/trimethoprim on fertility and fetal development in rats and rabbits (author's tranls)]. ( Helm, F; Kretzschmar, R; Leuschner, F; Neumann, W, 1976) |
| " There are no consequences concerning the dosage of Berlocombin in bacterial infections during pregnancy." | 1.26 | [Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy]. ( Müller, B; Nöschel, H; Peiker, G; Pischke, U; Schröder, S; Traeger, A, 1982) |
| "Chloramphenicol was give to 45, ampicillin to 19." | 1.25 | [Clinical course of typhoid in the Heidelberg region (author's transl)]. ( Bamberger, M; Gasparaitis, A; Kredel, L; Schettler, G, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 93 (73.81) | 18.7374 |
| 1990's | 11 (8.73) | 18.2507 |
| 2000's | 6 (4.76) | 29.6817 |
| 2010's | 14 (11.11) | 24.3611 |
| 2020's | 2 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Rodriguez, JB | 1 |
| Szajnman, SH | 1 |
| Kurosawa, K | 1 |
| Chiba, K | 1 |
| Noguchi, S | 1 |
| Nishimura, T | 1 |
| Tomi, M | 1 |
| Jee, J | 1 |
| Mourya, R | 1 |
| Shivakumar, P | 1 |
| Fei, L | 1 |
| Wagner, M | 1 |
| Bezerra, JA | 1 |
| Roh, ME | 1 |
| Shiboski, S | 1 |
| Natureeba, P | 1 |
| Kakuru, A | 1 |
| Muhindo, M | 1 |
| Ochieng, T | 1 |
| Plenty, A | 1 |
| Koss, CA | 1 |
| Clark, TD | 1 |
| Awori, P | 1 |
| Nakalambe, M | 1 |
| Cohan, D | 1 |
| Jagannathan, P | 1 |
| Gosling, R | 1 |
| Havlir, DV | 1 |
| Kamya, MR | 1 |
| Dorsey, G | 1 |
| Muanda, FT | 1 |
| Sheehy, O | 1 |
| Bérard, A | 1 |
| Abdullah, NL | 1 |
| Gunasekaran, R | 1 |
| Mohd-Zin, SW | 1 |
| Lim, BH | 1 |
| Maniam, P | 1 |
| Mohd-Salleh, AS | 1 |
| Thong, MK | 1 |
| Chik, Z | 1 |
| Nordin, N | 1 |
| Omar, Z | 1 |
| Engkasan, JP | 1 |
| Ganesan, D | 1 |
| Aiezzah, ZN | 1 |
| Ahmad-Annuar, A | 1 |
| Abdul-Aziz, NM | 1 |
| Sun, Y | 1 |
| Wu, CS | 1 |
| Olsen, J | 1 |
| Wang, X | 1 |
| Tan, Z | 1 |
| Cheng, G | 1 |
| Awais, I | 1 |
| Huang, L | 1 |
| Chen, D | 1 |
| Pan, Y | 1 |
| Liu, Z | 1 |
| Yuan, Z | 1 |
| Hansen, C | 1 |
| Andrade, SE | 1 |
| Freiman, H | 1 |
| Dublin, S | 1 |
| Haffenreffer, K | 1 |
| Cooper, WO | 1 |
| Cheetham, TC | 1 |
| Toh, S | 1 |
| Li, DK | 1 |
| Raebel, MA | 1 |
| Kuntz, JL | 1 |
| Perrin, N | 1 |
| Rosales, AG | 1 |
| Carter, S | 1 |
| Pawloski, PA | 1 |
| Maloney, EM | 1 |
| Graham, DJ | 1 |
| Sahin, L | 1 |
| Scott, PE | 1 |
| Yap, J | 1 |
| Davis, R | 1 |
| Rocha-Castro, J | 1 |
| Kronbauer, K | 1 |
| Dallé, J | 1 |
| Jimenez, MF | 1 |
| Riche, CW | 1 |
| Santiago, JA | 1 |
| Antonello, VS | 1 |
| Green, M | 1 |
| Otieno, K | 1 |
| Katana, A | 1 |
| Slutsker, L | 1 |
| Kariuki, S | 1 |
| Ouma, P | 1 |
| González, R | 1 |
| Menendez, C | 1 |
| ter Kuile, F | 1 |
| Desai, M | 1 |
| Gauld, NJ | 1 |
| Zeng, IS | 1 |
| Ikram, RB | 1 |
| Thomas, MG | 1 |
| Buetow, SA | 1 |
| Orden-Martínez, B | 1 |
| Martínez-Ruiz, R | 1 |
| Millán-Pérez, R | 1 |
| Bischoff, A | 1 |
| Melendez, J | 1 |
| Claxton, A | 1 |
| Erskine, K | 1 |
| Andersen, JT | 1 |
| Petersen, M | 1 |
| Jimenez-Solem, E | 1 |
| Broedbaek, K | 1 |
| Andersen, EW | 1 |
| Andersen, NL | 1 |
| Afzal, S | 1 |
| Torp-Pedersen, C | 1 |
| Keiding, N | 1 |
| Poulsen, HE | 1 |
| Barwitz, HJ | 1 |
| Ismaili, K | 1 |
| Hall, M | 1 |
| Piepsz, A | 1 |
| Wissing, KM | 1 |
| Collier, F | 1 |
| Schulman, C | 1 |
| Avni, FE | 1 |
| Schmiemann, G | 1 |
| Hummers-Pradier, E | 1 |
| Leeming, RJ | 1 |
| Reeves, D | 1 |
| Smithells, RW | 1 |
| Johnson, CA | 1 |
| Bennett, M | 1 |
| Jensen, RK | 1 |
| Schirmer, R | 1 |
| Nguyen, BT | 2 |
| Stadtsbaeder, S | 2 |
| Harpey, JP | 1 |
| Veron, P | 1 |
| Ruiz López, R | 1 |
| Saavedra, S | 1 |
| Ramírez-Ronda, CH | 2 |
| Harris, RE | 2 |
| Buongiorno, R | 1 |
| Schiraldi, O | 1 |
| Abraham, E | 1 |
| Brenner, BE | 1 |
| Simon, RR | 1 |
| Sommers, DK | 1 |
| Ronald, AR | 1 |
| Bailey, RR | 4 |
| Bishop, V | 2 |
| Peddie, BA | 2 |
| Daum, RS | 1 |
| Glode, MP | 1 |
| Wenzel, E | 2 |
| Wańkowicz, B | 2 |
| Prokopczyk, J | 2 |
| Brumfitt, W | 4 |
| Hamilton-Miller, JM | 1 |
| Kannangara, DW | 1 |
| Lefrock, JL | 1 |
| Harvengt, C | 1 |
| Peiker, G | 1 |
| Traeger, A | 1 |
| Pischke, U | 1 |
| Schröder, S | 1 |
| Müller, B | 1 |
| Nöschel, H | 1 |
| Gleckman, RA | 1 |
| Kreutz, R | 1 |
| Haliniarz, W | 2 |
| Sikorski, R | 2 |
| Alexander, TJ | 1 |
| Thornton, K | 1 |
| Boon, G | 1 |
| Lysons, RJ | 1 |
| Gush, AF | 1 |
| Küng, K | 1 |
| Hellwig, EG | 1 |
| Wanner, M | 1 |
| Post, K | 1 |
| Panciera, DL | 1 |
| Clark, EG | 1 |
| Ajisawa, A | 1 |
| Martens, M | 1 |
| Son, DS | 1 |
| Shimoda, M | 1 |
| Kokve, E | 1 |
| Mengelers, MJ | 1 |
| Kleter, GA | 1 |
| Hoogenboom, LA | 1 |
| Kuiper, HA | 1 |
| Van Miert, AS | 1 |
| Scott, JE | 1 |
| Swallow, V | 1 |
| Coulthard, MG | 1 |
| Lambert, HJ | 1 |
| Lee, RE | 1 |
| Amitai, Y | 1 |
| Leventhal, A | 1 |
| Wiersma, TJ | 1 |
| Timmermans, AE | 1 |
| Kensit, J | 1 |
| Herxheimer, A | 1 |
| Heidt, PJ | 1 |
| Timmermans, CP | 1 |
| Raczyński, A | 1 |
| Troszyński, M | 1 |
| Pepper, TA | 1 |
| Taylor, DJ | 1 |
| Hof, H | 1 |
| Boisen, E | 1 |
| Nielsen, JB | 1 |
| El Sanousi, SM | 1 |
| El Tayeb Amna, B | 1 |
| Shadad, EY | 1 |
| de Pascale, V | 1 |
| Crema, A | 1 |
| Craveri, F | 1 |
| Mandelli, V | 1 |
| Finch, RG | 1 |
| French, GL | 1 |
| Phillips, I | 1 |
| Craig, WA | 1 |
| Helm, F | 1 |
| Kretzschmar, R | 1 |
| Leuschner, F | 1 |
| Neumann, W | 1 |
| Kredel, L | 1 |
| Gasparaitis, A | 1 |
| Schettler, G | 1 |
| Bamberger, M | 1 |
| Reid, DW | 1 |
| Caille, G | 1 |
| Kaufmann, NR | 1 |
| Samin, F | 1 |
| Yedo-Yedes, P | 1 |
| Schiffman, DO | 1 |
| Gaudreault, P | 1 |
| Beland, M | 1 |
| Girodias, JB | 1 |
| Thivierge, RL | 1 |
| Bawdon, RE | 1 |
| Maberry, MC | 1 |
| Fortunato, SJ | 1 |
| Gilstrap, LC | 1 |
| Kim, S | 1 |
| Gordon, AC | 1 |
| Thomas, DF | 1 |
| Arthur, RJ | 1 |
| Irving, HC | 1 |
| Smith, SE | 1 |
| Al-Dubooni, HM | 1 |
| Al-Shirkat, SA | 1 |
| Nagi, NA | 1 |
| Boyd, EH | 1 |
| Allen, WE | 1 |
| Sarti, GM | 1 |
| Cruikshank, DP | 1 |
| Warenski, JC | 1 |
| Santana, JL | 1 |
| Bartlett, MS | 1 |
| Durkin, MM | 1 |
| Jay, MA | 1 |
| Queener, SF | 1 |
| Smith, JW | 1 |
| Davis, RE | 1 |
| Soper, DE | 1 |
| Merrill-Nach, S | 1 |
| Ganesh, V | 1 |
| Apuzzio, JJ | 1 |
| Dispenziere, B | 1 |
| Patel, K | 1 |
| Bergen, B | 1 |
| Louria, DB | 1 |
| Block, JM | 1 |
| Walstad, RA | 1 |
| Bjertnaes, A | 1 |
| Hafstad, PE | 1 |
| Holte, M | 1 |
| Ottemo, I | 1 |
| Svarva, PL | 1 |
| Rolstad, T | 1 |
| Peterson, LE | 1 |
| Whitworth, JA | 1 |
| Berg, AO | 1 |
| Soman, MP | 1 |
| Kelly, RT | 1 |
| Bibbins, B | 1 |
| Fowler, JE | 1 |
| Awadalla, SG | 1 |
| Mercer, LJ | 1 |
| Brown, LG | 1 |
| Pahnke, VG | 1 |
| Kitschke, HJ | 1 |
| Bernauer, M | 1 |
| Koll, R | 1 |
| van Spreeuwel, JP | 1 |
| Remmert, BP | 1 |
| Le Loux, AM | 1 |
| Nadorp, JH | 1 |
| Mevissen-Verhage, EA | 1 |
| Heilmann, FG | 1 |
| Verbrugh, HA | 1 |
| Kayser, AM | 1 |
| Landheer, JE | 1 |
| Harper, JS | 1 |
| London, WT | 1 |
| Sever, JL | 1 |
| el-Tamtamy, S | 1 |
| Schulz, R | 3 |
| Salter, AJ | 1 |
| Hing, NK | 1 |
| Hai, CK | 1 |
| Ping, WW | 1 |
| Godts, P | 1 |
| Wren, BG | 1 |
| Pursell, R | 3 |
| Bailey, MJ | 1 |
| Neary, JT | 1 |
| Notelovitz, M | 1 |
| Coggiola, F | 1 |
| Herbert, V | 1 |
| Shaw, EJ | 1 |
| Clark, AD | 1 |
| Anderson, FM | 1 |
| Domart, A | 1 |
| Robineau, M | 1 |
| Carbon, C | 1 |
| Spector, I | 1 |
| Green, R | 1 |
| Bowes, D | 1 |
| Cohen, H | 1 |
| Miller, S | 1 |
| Metz, J | 1 |
| Samim, F | 1 |
| Ylikorkala, O | 1 |
| Sjöstedt, E | 1 |
| Järvinen, PA | 1 |
| Tikkanen, R | 1 |
| Raines, T | 1 |
| Finland, M | 2 |
| Kass, EH | 1 |
| Backlund, I | 1 |
| Lagerstedt, B | 1 |
| Nyström, B | 1 |
| Tunell, R | 1 |
| de Tourris, H | 1 |
| Kamina, P | 1 |
| Allal, A | 1 |
| Hauser, GA | 1 |
| McEwen, LM | 1 |
| Villard, J | 1 |
| Bobichon, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Reducing the Burden of Malaria in HIV-Infected Pregnant Women and Their HIV-Exposed Children (PROMOTE Birth Cohort 2)[NCT02282293] | Phase 3 | 200 participants (Actual) | Interventional | 2014-12-09 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Proportion with low birth weight (<2500 gm), spontaneous abortion (<28 weeks), stillbirth (fetal demise ≥28 weeks), congenital anomaly, or preterm delivery (<37 weeks) (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 15 |
| Daily TS + Monthly DP Pregnancy | 20 |
The primary outcome will be the incidence of malaria, defined as the number of incident episodes per time at risk. Incident cases will include all treatments for malaria not proceeded by another treatment in the previous 14 days. (NCT02282293)
Timeframe: Time at risk will begin following administration of first dose of study drug to delivery
| Intervention | Events per person-year (Number) |
|---|---|
| TS + DP Placebo Pregnancy | 0.03 |
| Daily TS + Monthly DP Pregnancy | 0.00 |
Proportion of monthly routine blood samples positive by LAMP for parasites (NCT02282293)
Timeframe: Following administration of first dose of study drug to delivery
| Intervention | visits with positive blood sample (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 12 |
| Daily TS + Monthly DP Pregnancy | 5 |
The primary outcome will be the prevalence of placental malaria based on placental histopathology and dichotomized into any evidence of placental infection (parasites or pigment) vs. no evidence of placental infection. (NCT02282293)
Timeframe: at delivery estimated to be within 10 to 30 weeks of study entry
| Intervention | Participants (Count of Participants) |
|---|---|
| TS + DP Placebo Pregnancy | 3 |
| Daily TS + Monthly DP Pregnancy | 6 |
Anemia (hemoglobin less than 11g/dL) measured every 8 weeks during pregnancy (NCT02282293)
Timeframe: Following administration of first dose of study drugs to delivery
| Intervention | Routine visit done every 8 weeks (Count of Units) |
|---|---|
| TS + DP Placebo Pregnancy | 65 |
| Daily TS + Monthly DP Pregnancy | 51 |
Proportion of women with parasitemia detected by microscopy or LAMP at delivery (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy | LAMP | |
| Daily TS + Monthly DP Pregnancy | 1 | 4 |
| TS + DP Placebo Pregnancy | 0 | 2 |
Proportion of placental blood samples positive for malaria by microscopy or PCR (NCT02282293)
Timeframe: At delivery
| Intervention | Participants (Count of Participants) | |
|---|---|---|
| Microscopy of placental blood | LAMP analysis of placental blood | |
| Daily TS + Monthly DP Pregnancy | 1 | 3 |
| TS + DP Placebo Pregnancy | 0 | 1 |
13 reviews available for trimethoprim and Pregnancy
| Article | Year |
|---|---|
An updated review of chemical compounds with anti-Toxoplasma gondii activity.
Topics: Animals; Atovaquone; Female; Humans; Mammals; Pregnancy; Toxoplasma; Toxoplasmosis; Trimethoprim | 2023 |
Cystitis and pyelonephritis.
Topics: Amoxicillin; Bacterial Infections; Bacteriuria; Cystitis; Diagnosis, Differential; Drug Therapy, Com | 1983 |
Pharmacological principles in the treatment of urinary tract infections.
Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cephalosporins; Female; Huma | 1983 |
Current concepts in the management of urinary tract infections in adults.
Topics: Adult; Aged; Amoxicillin; Bacteriuria; Female; Humans; Male; Middle Aged; Nephritis; Pregnancy; Preg | 1984 |
Trimethoprim.
Topics: Anti-Infective Agents, Urinary; Bacteriuria; Drug Resistance, Microbial; Drug Therapy, Combination; | 1980 |
Management of lower urinary tract infections.
Topics: 4-Quinolones; Anti-Bacterial Agents; Anti-Infective Agents; Female; Humans; Pregnancy; Pregnancy Com | 1993 |
[Summary of the 'Urinary tract infections' guideline (first revision) of the Dutch College of General Practitioners].
Topics: Adult; Amoxicillin; Anti-Infective Agents, Urinary; Diagnosis, Differential; Female; Humans; Netherl | 2001 |
Ad Hoc Committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety.
Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Child; Clindamycin; Clinical Trials as Topi | 1975 |
Aerosolized pentamidine in HIV. Promising new treatment for Pneumocystis carinii pneumonia.
Topics: Aerosols; Amidines; Animals; Anti-Infective Agents; Child; Drug Combinations; Female; HIV Seropositi | 1989 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
Single-dose therapy in the management of urinary tract infections.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cephalosporins; Child | 1986 |
Lower genitourinary infections in women.
Topics: Amoxicillin; Anti-Infective Agents, Urinary; Cystitis; Diagnosis, Differential; Drug Combinations; F | 1986 |
Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man.
Topics: Agranulocytosis; Aminobenzoates; Anemia; Bile; Biological Transport, Active; Bone Marrow; Bone Marro | 1973 |
17 trials available for trimethoprim and Pregnancy
| Article | Year |
|---|---|
Protective Effect of Indoor Residual Spraying of Insecticide on Preterm Birth Among Pregnant Women With HIV Infection in Uganda: A Secondary Data Analysis.
Topics: Adolescent; Adult; Anti-Retroviral Agents; Chemoprevention; Drug Combinations; Female; HIV Infection | 2017 |
Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.
Topics: Adolescent; Adult; Antimalarials; Double-Blind Method; Female; HIV Infections; Humans; Kenya; Malari | 2016 |
Comparison of single dose with a 5-day course of co-trimoxazole for asymptomatic (covert) bacteriuria of pregnancy.
Topics: Adult; Anti-Infective Agents, Urinary; Drug Administration Schedule; Drug Combinations; Female; Huma | 1983 |
Rifampin prophylaxis against H. flu type b spread - is it valid?
Topics: Adolescent; Adult; Carrier State; Cellulitis; Child; Child, Preschool; Clinical Trials as Topic; Dou | 1982 |
Screening of newborn babies for familial ureteric reflux.
Topics: Female; Genetic Linkage; Humans; Infant, Newborn; Kidney; Male; Neonatal Screening; Pregnancy; Radio | 1997 |
Ad Hoc Committee report: systemic antibiotics for treatment of acne vulgaris: efficacy and safety.
Topics: Acne Vulgaris; Adolescent; Adult; Anti-Bacterial Agents; Child; Clindamycin; Clinical Trials as Topi | 1975 |
Single daily doses of trimethoprim/sulphadiazine for three or 10 days in urinary tract infections.
Topics: Adolescent; Anti-Infective Agents, Urinary; Child; Child, Preschool; Drug Combinations; Escherichia | 1992 |
Comparison of single dose with a five-day course of trimethoprim for asymptomatic (covert) bacteriuria of pregnancy.
Topics: Adolescent; Adult; Bacteriuria; Drug Administration Schedule; Drug Evaluation; Female; Humans; Pregn | 1986 |
Single-dose trimethoprim-sulfamethoxazole prophylaxis for cesarean section.
Topics: Adolescent; Anti-Infective Agents; Cesarean Section; Drug Combinations; Endometritis; Female; Humans | 1986 |
Ofloxacin versus trimethoprim-sulphamethoxazole in acute cystitis.
Topics: Acute Disease; Anti-Infective Agents; Cystitis; Drug Combinations; Female; Humans; Infant, Newborn; | 1987 |
Single-dose therapy in the management of urinary tract infections.
Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents, Urinary; Cephalosporins; Child | 1986 |
Double-blind trial comparing trimethoprim-sulphamethoxazole (bactrim) with ampicillin in treating urinary infections.
Topics: Ampicillin; Anti-Infective Agents; Clinical Trials as Topic; Drug Combinations; Drug Synergism; Fema | 1972 |
Double-blind trial to compare ampicillin, cephalexin, co-trimoxazole, and trimethoprim in treatment of urinary infection.
Topics: Ampicillin; Bacteriuria; Cephalexin; Cephalosporins; Drug Hypersensitivity; Escherichia coli Infecti | 1972 |
A comparison of trimethoprim-sulphamethoxazole compound and tetracycline in exacerbations of chronic bronchitis. A double-blind multi-centre trial on in-patients.
Topics: Aged; Anti-Infective Agents; Bacteriological Techniques; Bronchitis; Child; Chronic Disease; Clinica | 1972 |
[Preliminary results of treatment of symptomatic and asymptomatic bacteriuria in pregnancy with a new chemotherapeutic agent].
Topics: Adult; Anti-Infective Agents; Bacteriuria; Clinical Trials as Topic; Evaluation Studies as Topic; Fe | 1973 |
Trimethoprim-sulphamethoxazole in the treatment of urinary infection.
Topics: Abnormalities, Drug-Induced; Ampicillin; Anti-Infective Agents; Cephalexin; Clinical Trials as Topic | 1973 |
Trimethoprim-sulfamethoxazole in the treatment of bacteriuria in women.
Topics: Abnormalities, Drug-Induced; Ambulatory Care; Ampicillin; Bacteriuria; Cephalexin; Clinical Trials a | 1973 |
98 other studies available for trimethoprim and Pregnancy
| Article | Year |
|---|---|
Development of a Pharmacokinetic Model of Transplacental Transfer of Metformin to Predict In Vivo Fetal Exposure.
Topics: Cell Membrane; Computer Simulation; Female; Fetus; Humans; Maternal-Fetal Exchange; Metformin; Model | 2020 |
Cxcr2 signaling and the microbiome suppress inflammation, bile duct injury, and the phenotype of experimental biliary atresia.
Topics: Animals; Bile Ducts; Biliary Atresia; Disease Models, Animal; Female; Gene Expression Profiling; Inf | 2017 |
Use of trimethoprim-sulfamethoxazole during pregnancy and risk of spontaneous abortion: a nested case control study.
Topics: Abortion, Spontaneous; Adolescent; Adult; Anti-Bacterial Agents; Case-Control Studies; Drug Combinat | 2018 |
Cranial neural tube defect after trimethoprim exposure.
Topics: Animals; Anti-Infective Agents, Urinary; Female; Germany; Japan; Malaysia; Male; Mice; Neural Tube D | 2018 |
Trimethoprim use before pregnancy and risk of congenital malformation: reanalyzed using a case-crossover design and a case-time-control design.
Topics: Abnormalities, Drug-Induced; Case-Control Studies; Cross-Over Studies; Denmark; Electronic Health Re | 2014 |
Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Anti-Bacterial Agents; Dose-Response Rel | 2015 |
Trimethoprim-sulfonamide use during the first trimester of pregnancy and the risk of congenital anomalies.
Topics: Abnormalities, Drug-Induced; Adult; Anti-Bacterial Agents; Cohort Studies; Female; Humans; Infant; I | 2016 |
Characteristics of bacterial acute diarrhea among women.
Topics: Adolescent; Adult; Ampicillin; Anti-Bacterial Agents; Brazil; Ceftriaxone; Ciprofloxacin; Cross-Sect | 2016 |
Trimethoprim during the 3 months before pregnancy: malformations in children.
Topics: Abnormalities, Drug-Induced; Anti-Infective Agents, Urinary; Female; Folic Acid; Folic Acid Antagoni | 2016 |
Treatment of uncomplicated cystitis: analysis of prescribing in New Zealand.
Topics: Adolescent; Adult; Aged; Anti-Infective Agents; Cystitis; Dose-Response Relationship, Drug; Drug Pre | 2016 |
[What are we learning about Staphylococcus saprophyticus?].
Topics: Adolescent; Adult; Anti-Bacterial Agents; Contraindications; Drug Combinations; Drug Resistance, Mul | 2008 |
[Urological emergencies in family practice.Terrible pain, blood in the urine].
Topics: Aged; Anti-Infective Agents, Urinary; Diagnosis, Differential; Emergencies; Family Practice; Female; | 2010 |
MRSA bacteraemia after caesarean section wound infection: when screening is missed and things go wrong.
Topics: Adult; Amikacin; Anti-Bacterial Agents; Antibiotic Prophylaxis; Bacteremia; Cefuroxime; Cesarean Sec | 2012 |
Trimethoprim use in early pregnancy and the risk of miscarriage: a register-based nationwide cohort study.
Topics: Abortion, Spontaneous; Adult; Anti-Infective Agents, Urinary; Cohort Studies; Denmark; Female; Folic | 2013 |
[Dysuria].
Topics: Adult; Anti-Infective Agents, Urinary; Child; Cystitis; Female; Humans; Male; Pregnancy; Pregnancy C | 2003 |
Primary vesicoureteral reflux detected in neonates with a history of fetal renal pelvis dilatation: a prospective clinical and imaging study.
Topics: Anti-Infective Agents, Urinary; Antibiotic Prophylaxis; Chelating Agents; Chromium Radioisotopes; Ed | 2006 |
[Urinary tract infection].
Topics: Adult; Diagnosis, Differential; Dysuria; Female; Humans; Middle Aged; Nitrofurantoin; Pregnancy; Rec | 2007 |
Co-trimoxazole and phenylalanine metabolism.
Topics: Child; Drug Synergism; Female; Humans; Phenylalanine; Pregnancy; Sulfamethoxazole; Trimethoprim | 1980 |
Sulphonamides and trimethoprim.
Topics: Bacterial Infections; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Fema | 1982 |
Co-trimoxazole in pregnancy.
Topics: Anti-Infective Agents; Drug Combinations; Female; Humans; Pregnancy; Pregnancy Complications, Infect | 1983 |
Effect of combined antibiotic therapy on fertility in brood bitches infected with Brucella canis.
Topics: Abortion, Septic; Abortion, Veterinary; Animals; Brucellosis; Dihydrostreptomycin Sulfate; Dog Disea | 1982 |
[Therapeutic future of trimethoprim-sulfamethoxazole in toxoplasmosis].
Topics: Animals; Drug Combinations; Female; Humans; Mice; Pregnancy; Sulfamethoxazole; Toxoplasmosis; Toxopl | 1983 |
[Treatment of toxoplasmosis with trimethoprim-sulfamethoxazole].
Topics: Drug Combinations; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Sulfamethoxazole; | 1983 |
Therapeutic progress: trimethoprim-sulfamethoxazole.
Topics: Anti-Infective Agents, Urinary; Bacterial Infections; Drug Combinations; Female; Humans; Male; Pregn | 1984 |
Acute urinary tract infections and subsequent problems.
Topics: Acute Disease; Aminoglycosides; Anti-Bacterial Agents; Bacteriuria; Cystitis; Drug Combinations; Fem | 1984 |
Treatment of typhoid fever in pregnancy.
Topics: Adolescent; Adult; Ampicillin; Chloramphenicol; Drug Combinations; Female; Humans; Pregnancy; Pregna | 1984 |
Single-dose antibacterial treatment for bacteriuria in pregnancy.
Topics: Bacteriuria; Cephaloridine; Drug Combinations; Drug Therapy, Combination; Female; Humans; Nitrofuran | 1984 |
[The effect of biseptol and sodium salicylate administration on the concentration of serotonin and histamine and mono- and diamine oxidase activities in rat placenta].
Topics: Amine Oxidase (Copper-Containing); Animals; Drug Combinations; Enzyme Activation; Female; Histamine; | 1982 |
Drugs for urinary tract infections in women.
Topics: Aged; Ampicillin; Anti-Bacterial Agents; Drug Therapy, Combination; Escherichia coli Infections; Fem | 1981 |
[Recently registered drugs].
Topics: Enterobacteriaceae Infections; Female; Humans; Pregnancy; Trimethoprim; Urinary Tract Infections | 1982 |
[Studies on the pharmacokinetics of the compound preparation sulfamerazine/trimethoprim (Berlocombin-200) in pregnancy].
Topics: Drug Combinations; Female; Half-Life; Humans; Kinetics; Pregnancy; Sulfamerazine; Trimethoprim | 1982 |
Introduction of trimethoprim: a mixed blessing.
Topics: Bacterial Infections; Female; Humans; Pregnancy; Trimethoprim; Urinary Tract Infections | 1981 |
[Investigation on the influence of trimethoprim at the intrauterine development in the rat (author's transl)].
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Embryo Implantation; Female; Fetal Resor | 1981 |
[Evaluation of embryotoxicity of Biseptol-Polfa in pregnant female rats and rabbits].
Topics: Animals; Drug Combinations; Drug Evaluation, Preclinical; Ecchymosis; Edema; Embryo, Mammalian; Fema | 1980 |
Medicated early weaning to obtain pigs free from pathogens endemic in the herd of origin.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Bordetella; Colon; Diterpenes; Female; Housing | 1980 |
Pharmacokinetics of sulphadoxine and trimethoprim in sows: influence of lactation.
Topics: Animals; Drug Combinations; Female; Injections, Intravenous; Lactation; Milk; Pregnancy; Sulfadoxine | 1994 |
Lack of effect of trimethoprim and sulfadiazine in combination in mid- to late gestation on thyroid function in neonatal dogs.
Topics: Animals; Animals, Newborn; Dogs; Drug Combinations; Female; Gestational Age; Maternal-Fetal Exchange | 1993 |
[Protozoan infections in AIDS].
Topics: Acquired Immunodeficiency Syndrome; Administration, Inhalation; AIDS-Related Opportunistic Infection | 1993 |
[Careful with trimethoprim in pregnant sows].
Topics: Abnormalities, Drug-Induced; Animals; Female; Pregnancy; Pregnancy Complications, Infectious; Swine; | 1993 |
Implication of altered levels of plasma alpha(1)-acid glycoprotein and its derived sialic acid on plasma protein binding of trimethoprim in pigs in physiological and pathological states.
Topics: Actinobacillus Infections; Actinobacillus pleuropneumoniae; Animals; Chromatography, High Pressure L | 1996 |
The biotransformation of sulfadimethoxine, sulfadimidine, sulfamethoxazole, trimethoprim and aditoprim by primary cultures of pig hepatocytes.
Topics: Acetylation; Animals; Anti-Infective Agents; Biotransformation; Cells, Cultured; Chromatography, Hig | 1997 |
Folic acid antagonists during pregnancy and risk of birth defects.
Topics: Abnormalities, Drug-Induced; Cleft Lip; Female; Folic Acid Antagonists; Heart Defects, Congenital; H | 2001 |
Prophylactic antimicrobial drug therapy at five London teaching hospitals. A report by the Study Group on the Use of Antimicrobial Drugs.
Topics: Administration, Oral; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Child; Cross Infection; F | 1977 |
[Studies on the embryotoxicity of the preparation Biseptol-Polfa in pregnant hamsters].
Topics: Abnormalities, Drug-Induced; Animals; Cricetinae; Drug Combinations; Drug Evaluation, Preclinical; E | 1979 |
Selective decontamination of the digestive tract of pregnant rabbits: a method for producing Enterobacteriaceae-free rabbits.
Topics: Animals; Cecum; Digestive System; Drug Combinations; Enterobacteriaceae; Feces; Female; Germ-Free Li | 1975 |
[Sulfamethoxazole concentration in the homogenate of the human embryo].
Topics: Biological Transport; Drug Combinations; Embryo, Mammalian; Female; Humans; Maternal-Fetal Exchange; | 1979 |
Breeding record analysis in pig herds and its veterinary applications--2: Experiences with a large commercial unit.
Topics: Abscess; Animals; Bordetella Infections; Breeding; Computers; Diarrhea; Escherichia coli Infections; | 1977 |
[Toxoplasma gondii. Infection and its prevention].
Topics: Animals; Antibody Formation; Cats; Chorioretinitis; Chronic Disease; Complement Fixation Tests; Dise | 1978 |
Postpartum urinary retention: role of antimicrobial therapy.
Topics: Ampicillin; Bacteriuria; Catheters, Indwelling; Drug Combinations; Female; Humans; Nitrofurantoin; P | 1979 |
[Adverse effects following sulfamethoxazole and trimethoprim. Review and 2 case reports].
Topics: Adult; Denmark; Drug Combinations; Female; Humans; Male; Middle Aged; Pregnancy; Sulfamethoxazole; T | 1979 |
Co-trimoxazole - too toxic for minor infections?
Topics: Drug Combinations; Female; Humans; Infant, Newborn; Pregnancy; Sulfamethoxazole; Trimethoprim | 1979 |
Bacteria isolated from uterine washings from mares in the Sudan.
Topics: Animals; Bacteria; Bacterial Infections; Female; Horse Diseases; Horses; Infertility, Female; Pregna | 1979 |
[Effects of trimethoprim-sulfamethozypyrazine combination on the reproduction in rats and rabbits].
Topics: Animals; Female; Lactation; Male; Pregnancy; Rabbits; Rats; Reproduction; Spermatogenesis; Sulfalene | 1979 |
Group B streptococci in the female genital tract.
Topics: Anti-Bacterial Agents; Carrier State; Contraceptives, Oral; Female; Humans; Labor, Obstetric; Leukor | 1976 |
Urinary tract infections: regimens to avoid recurrence.
Topics: Adult; Ampicillin; Carbenicillin; Cephalexin; Child; Female; Humans; Male; Middle Aged; Nalidixic Ac | 1977 |
[Investigations on the effect of the combination sulfamoxole/trimethoprim on fertility and fetal development in rats and rabbits (author's tranls)].
Topics: Abnormalities, Drug-Induced; Animals; Animals, Newborn; Birth Weight; Drug Combinations; Female; Fer | 1976 |
[Clinical course of typhoid in the Heidelberg region (author's transl)].
Topics: Abortion, Septic; Adult; Ampicillin; Chloramphenicol; Disease Outbreaks; Female; Gastrointestinal He | 1975 |
Maternal and transplacental kinetics of trimethoprim and sulfamethoxazole, separately and in combination.
Topics: Administration, Oral; Adult; Amniotic Fluid; Biological Assay; Colorimetry; Drug Combinations; Femal | 1975 |
[Retrospective study of bactrim tolerance(author's transl)].
Topics: Adolescent; Adult; Anti-Infective Agents; Drug Combinations; Drug Tolerance; Female; Humans; Liver; | 1975 |
Evaluation of an anti-infective combination. Trimethoprim-sulfamethoxazole (Bactrim, Septra).
Topics: Acute Disease; Administration, Oral; Adult; Bacteria; Bacterial Infections; Brucellosis; Child; Chro | 1975 |
Trimethoprim and sulfamethoxazole transfer in the in vitro perfused human cotyledon.
Topics: Female; Humans; Maternal-Fetal Exchange; Metabolic Clearance Rate; Placenta; Pregnancy; Sulfamethoxa | 1991 |
Prenatally diagnosed reflux: a follow-up study.
Topics: Female; Fetal Diseases; Follow-Up Studies; Humans; Infant, Newborn; Male; Pregnancy; Prenatal Diagno | 1990 |
Brucellosis in children in Iraq.
Topics: Adolescent; Age Factors; Agglutination Tests; Brucellosis; Child; Child, Preschool; Drug Combination | 1986 |
Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Child; Drug Combinations; Female; Humans; Infan | 1989 |
From the Centers for Disease Control. Guidelines for prophylaxis against Pneumocystis carinii pneumonia for persons infected with human immunodeficiency virus.
Topics: Acquired Immunodeficiency Syndrome; Adult; Aerosols; Anti-Bacterial Agents; Child; Drug Combinations | 1989 |
Absorption of two trimethoprim/sulphonamide combinations from the uterus of pony mares.
Topics: Absorption; Animals; Drug Combinations; Female; Horses; Lactation; Milk; Pregnancy; Sulfadiazine; Su | 1989 |
First-trimester maternal Listeria monocytogenes sepsis and chorioamnionitis with normal neonatal outcome.
Topics: Adult; Ampicillin; Anti-Infective Agents; Chorioamnionitis; Drug Combinations; Drug Therapy, Combina | 1989 |
[The pregnant woman infected with the human immunodeficiency virus: recommendations for her management].
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Cytomegalovirus Infections; Female; Humans; Ketocon | 1988 |
Sources of rats free of latent Pneumocystis carinii.
Topics: Animals; Disease Models, Animal; Drug Combinations; Female; Immunosuppression Therapy; Pneumonia, Pn | 1987 |
Successful therapy of penicillinase-producing Neisseria gonorrhoeae pharyngeal infection during pregnancy.
Topics: Adult; Anti-Bacterial Agents; Drug Combinations; Female; Gonorrhea; Humans; Infant, Newborn; Neisser | 1986 |
Pregnancy and brucellosis.
Topics: Adult; Brucellosis; Female; Humans; Pregnancy; Pregnancy Complications, Infectious; Recurrence; Sulf | 1987 |
Staphylococcus saprophyticus as the cause of infected urinary calculus.
Topics: Adult; Ampicillin; Bacteriuria; Drug Combinations; Female; Humans; Magnesium; Magnesium Compounds; P | 1985 |
Pregnancy complicated by intraamniotic infection by Salmonella typhi.
Topics: Abortion, Spontaneous; Adult; Amniotic Fluid; Ampicillin; Clindamycin; Disseminated Intravascular Co | 1985 |
[Nonpuerperal mastitis--a disease with increasing clinical relevance?].
Topics: Abscess; Adolescent; Adult; Aged; Anti-Bacterial Agents; Bromocriptine; Doxycycline; Drug Combinatio | 1985 |
Comparative effects of cotrimoxazole (trimethoprim-sulphamethoxazole) and spiramycin in pregnant mice infected with Toxoplasma gondii (Beverley strain).
Topics: Animals; Antibodies; Birth Weight; Congenital Abnormalities; Delivery, Obstetric; Drug Combinations; | 1985 |
[Clinical observations during an epidemic caused by Shigella flexneri].
Topics: Adult; Aged; Arthritis, Infectious; Child, Preschool; Drug Combinations; Dysentery, Bacillary; Femal | 1985 |
Five drug regimens for treatment of acute toxoplasmosis in squirrel monkeys.
Topics: Animals; Clindamycin; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Leuco | 1985 |
Editorial: Co-trimoxazole and blood.
Topics: Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Bone Marrow; Drug Combinations; Female; Folic | 1973 |
Letter: Co-trimoxazole and the blood.
Topics: Adult; Aged; Anemia, Macrocytic; Drug Combinations; Female; Folic Acid Deficiency; Humans; Male; Pre | 1974 |
Distribution and elimination of trimethoprim in pregnant and newborn rats.
Topics: Animals; Animals, Newborn; Anti-Infective Agents; Brain Chemistry; Female; Fetus; Fluorometry; Folic | 1972 |
Rat folic acid reductase activity during the perinatal period, in newborns, and after trimethoprim administration.
Topics: Administration, Oral; Animals; Animals, Newborn; Anti-Infective Agents; Dactinomycin; Female; Fetus; | 1972 |
Inhibition of rat folic acid reductase activity activity by trimethoprim during the later stages of gestation.
Topics: Administration, Oral; Animals; Anti-Infective Agents; Female; Fetus; Folic Acid Antagonists; Liver; | 1973 |
The toxicity profile of trimethoprim-sulphamethoxazole after four years of widespread use.
Topics: Abnormalities, Drug-Induced; Adolescent; Adult; Animals; Anti-Infective Agents; Child; Child, Presch | 1973 |
Trimethoprim-sulphamethoxazole in the treatment of infections in obstetrical and gynaecological practice. A bacteriological and clinical study.
Topics: Bacterial Infections; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications, | 1974 |
[Use of the antibacterial combination sulfamethoxazole + rimethoprim in the treatment of leukorrhea].
Topics: Adult; Aged; Drug Combinations; Female; Humans; Leukorrhea; Middle Aged; Pregnancy; Sulfamethoxazole | 1974 |
The Uricult dip-slide in significant bacteriuria.
Topics: Ampicillin; Bacteria; Bacteriological Techniques; Bacteriuria; Female; Humans; Microbial Sensitivity | 1972 |
R factors in Enterobacteriaceae causing asymptomatic bacteriuria of pregnancy.
Topics: Ampicillin; Bacteriuria; Chloramphenicol; Enterobacteriaceae; Enterobacteriaceae Infections; Escheri | 1973 |
[Acquired toxoplasmosis: a new chemotherapy: the sulfamethoxazole-trimethoprim combination].
Topics: Administration, Oral; Anti-Infective Agents; Drug Combinations; Female; Humans; Male; Pregnancy; Pro | 1973 |
Trimethoprim-sulphamethoxazole therapy and folate nutrition.
Topics: Adult; Anti-Infective Agents; Blood Cell Count; Bone Marrow Examination; Bronchopneumonia; Female; F | 1973 |
[Ad hoc administration of Bactrim(Roche) erfusion in obstetrics and gynecology].
Topics: Anti-Infective Agents; Drug Combinations; Female; Folic Acid Antagonists; Genital Diseases, Female; | 1973 |
Trimethoprim-sulfonamide combination administered orally and intravaginally in the first trimester of pregnancy: its absorption into serum and transfer to amniotic fluid.
Topics: Administration, Oral; Amniotic Fluid; Drug Combinations; Female; Half-Life; Humans; Ointments; Pregn | 1973 |
Trimethoprim-sulfamethoxazole. Summary and comments on the conference.
Topics: Bacteria; Bacterial Infections; Carrier State; Child; Child, Preschool; Drug Combinations; Drug Resi | 1973 |
[Spread of a Salmonella-Durham infection in a maternity clinic].
Topics: Birth Weight; Female; Humans; Hydrocephalus; Infant; Infant, Newborn; Infant, Premature; Meningitis; | 1973 |
Editorial: Combinations of antimicrobial drugs: trimethoprim-sulfamethoxazole.
Topics: Adult; American Medical Association; Ascorbic Acid; Attitude of Health Personnel; Bacterial Infectio | 1974 |
[Use of a new association trimethoprime-sulfamethoxazole in urinary infections in gyneco-obstetrics].
Topics: Abortion, Septic; Anti-Infective Agents; Female; Folic Acid Antagonists; Genital Diseases, Female; H | 1972 |
[Indications and results in the Bactrim treatment of gynecologic diseases].
Topics: Fallopian Tubes; Female; Folic Acid Antagonists; Genital Diseases, Female; Humans; Infertility, Fema | 1971 |
Trimethoprim-sulphamethoxazole mixture in pregnancy.
Topics: Abnormalities, Drug-Induced; Animals; Anti-Infective Agents; Drug Combinations; Female; Fetus; Folic | 1971 |
[Study of the sulfamethoxazole-trimethoprim combination in gynecology and obstetrics].
Topics: Abortion, Septic; Anti-Infective Agents; Female; Folic Acid Antagonists; Humans; Pregnancy; Pregnanc | 1971 |