trimethoprim has been researched along with Phenylketonurias in 6 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).
Excerpt | Relevance | Reference |
---|---|---|
"Patients with classical phenylketonuria did not show this effect." | 1.26 | Effect of cotrimoxazole on the response to phenylalanine loading in man. ( , 1976) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 6 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Dhondt, JL | 2 |
Farriaux, JP | 2 |
Dautrevaux, M | 1 |
Biserte, G | 1 |
Watts, RW | 1 |
Purkiss, P | 1 |
Chalmers, RA | 1 |
Goutet, JM | 1 |
Aymard, P | 1 |
Leroy, D | 1 |
Polonovski, C | 1 |
Navarro, J | 1 |
Pueschel, SM | 1 |
Boylan, J | 1 |
Ellenbogen, R | 1 |
6 other studies available for trimethoprim and Phenylketonurias
Article | Year |
---|---|
Study of blood aminoacids in experimental hyperphenylalaninemia.
Topics: Amino Acids; Animals; Disease Models, Animal; Fenclonine; Humans; Male; Phenylalanine; Phenylketonur | 1977 |
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
Topics: Animals; Disease Models, Animal; Drug Combinations; Fenclonine; Humans; Kidney; Liver; Male; Phenyla | 1977 |
A new variant form of phenylketonuria.
Topics: Adult; Child; Diseases in Twins; Drug Combinations; Drug Tolerance; Female; Humans; Intelligence; Ma | 1979 |
[Hyperphenylalaninemia induced by trimethoprim-sulfamethoxazole in an infant heterozygous for phenylketonuria].
Topics: Heterozygote; Humans; Infant; Male; Phenylalanine; Phenylketonurias; Sulfamethoxazole; Trimethoprim | 1979 |
Effect of cotrimoxazole on the response to phenylalanine loading in man.
Topics: Adult; Amino Acid Metabolism, Inborn Errors; Drug Combinations; Female; Glomerular Filtration Rate; | 1976 |
Studies on experimentally induced hyperphenylalaninemia.
Topics: Animals; Disease Models, Animal; Drug Combinations; Female; Fenclonine; Phenylalanine; Phenylalanine | 1988 |