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trimethoprim and Phenylketonurias

trimethoprim has been researched along with Phenylketonurias in 6 studies

Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.

Phenylketonurias: A group of autosomal recessive disorders marked by a deficiency of the hepatic enzyme PHENYLALANINE HYDROXYLASE or less frequently by reduced activity of DIHYDROPTERIDINE REDUCTASE (i.e., atypical phenylketonuria). Classical phenylketonuria is caused by a severe deficiency of phenylalanine hydroxylase and presents in infancy with developmental delay; SEIZURES; skin HYPOPIGMENTATION; ECZEMA; and demyelination in the central nervous system. (From Adams et al., Principles of Neurology, 6th ed, p952).

Research Excerpts

ExcerptRelevanceReference
"Patients with classical phenylketonuria did not show this effect."1.26Effect of cotrimoxazole on the response to phenylalanine loading in man. ( , 1976)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19906 (100.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dhondt, JL2
Farriaux, JP2
Dautrevaux, M1
Biserte, G1
Watts, RW1
Purkiss, P1
Chalmers, RA1
Goutet, JM1
Aymard, P1
Leroy, D1
Polonovski, C1
Navarro, J1
Pueschel, SM1
Boylan, J1
Ellenbogen, R1

Other Studies

6 other studies available for trimethoprim and Phenylketonurias

ArticleYear
Study of blood aminoacids in experimental hyperphenylalaninemia.
    Biomedicine / [publiee pour l'A.A.I.C.I.G.], 1977, Volume: 27, Issue:2

    Topics: Amino Acids; Animals; Disease Models, Animal; Fenclonine; Humans; Male; Phenylalanine; Phenylketonur

1977
A new experimental model of hyperphenylalaninemia in rat. Effect of p-chlorophenylalanine and cotrimoxazole.
    Biochimie, 1977, Volume: 59, Issue:8-9

    Topics: Animals; Disease Models, Animal; Drug Combinations; Fenclonine; Humans; Kidney; Liver; Male; Phenyla

1977
A new variant form of phenylketonuria.
    The Quarterly journal of medicine, 1979, Volume: 48, Issue:191

    Topics: Adult; Child; Diseases in Twins; Drug Combinations; Drug Tolerance; Female; Humans; Intelligence; Ma

1979
[Hyperphenylalaninemia induced by trimethoprim-sulfamethoxazole in an infant heterozygous for phenylketonuria].
    La Nouvelle presse medicale, 1979, Dec-17, Volume: 8, Issue:49

    Topics: Heterozygote; Humans; Infant; Male; Phenylalanine; Phenylketonurias; Sulfamethoxazole; Trimethoprim

1979
Effect of cotrimoxazole on the response to phenylalanine loading in man.
    Clinica chimica acta; international journal of clinical chemistry, 1976, Apr-01, Volume: 68, Issue:1

    Topics: Adult; Amino Acid Metabolism, Inborn Errors; Drug Combinations; Female; Glomerular Filtration Rate;

1976
Studies on experimentally induced hyperphenylalaninemia.
    Journal of mental deficiency research, 1988, Volume: 32 ( Pt 4)

    Topics: Animals; Disease Models, Animal; Drug Combinations; Female; Fenclonine; Phenylalanine; Phenylalanine

1988