trimethoprim has been researched along with Opportunistic Infections in 31 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Opportunistic Infections: An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Fever, hypotension, pulmonary infiltrates, and hypoxemia developed upon re-exposure to trimethoprim-sulfamethoxazole in 2 patients with the Acquired Immunodeficiency Syndrome." | 7.67 | Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole. ( Alexander, RC; Jensen, WA; Rose, RM; Silvestri, RC; Zibrak, JD, 1987) |
| " Here we describe the occurrence of severe combined immunodeficiency (SCID) with megaloblastic anemia, leukopenia, atypical hemolytic uremic syndrome, and neurologic abnormalities in which hydroxocobalamin and folate therapy provided partial immune reconstitution." | 3.79 | Severe combined immunodeficiency resulting from mutations in MTHFD1. ( Baluarte, HJ; Bergqvist, AG; Ganesh, J; Heltzer, M; Keller, MD; Orange, JS; Paessler, M; Rosenblatt, DS; Watkins, D, 2013) |
| "Fever, hypotension, pulmonary infiltrates, and hypoxemia developed upon re-exposure to trimethoprim-sulfamethoxazole in 2 patients with the Acquired Immunodeficiency Syndrome." | 3.67 | Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole. ( Alexander, RC; Jensen, WA; Rose, RM; Silvestri, RC; Zibrak, JD, 1987) |
| "Voriconazole was used to treat pulmonary aspergillosis, besides sulfamethoxazole and trimethoprim (SMZ-TMP), and caspofungin acetate to treat Pneumocystis jirovecii infection for 6 days." | 1.62 | Rapid and precise diagnosis of pneumonia coinfected by Pneumocystis jirovecii and Aspergillus fumigatus assisted by next-generation sequencing in a patient with systemic lupus erythematosus: a case report. ( Ai, L; Chen, Y; Huang, J; Liang, Y; Tang, W; Zhao, Y; Zhou, Y, 2021) |
| " Antimicrobial treatment-related side effects require close monitoring, and dosage changes or therapy adjustments may be necessary." | 1.46 | First reported case of disseminated Nocardia kroppenstedtii sp nov. infection presenting with brain abscess and endocarditis in an immunocompromised patient with mantle cell lymphoma: challenges in diagnosis and treatment. ( Abdullah, HM; Al Mohajer, M; Majeed, A; Ullah, W, 2017) |
| "The predisposing conditions were COPD (23%), transplantation (29%), HIV infection (19%), alcoholism (6." | 1.34 | Pulmonary nocardiosis: risk factors and outcomes. ( Gobernado Serrano, M; Martínez Tomás, R; Menéndez Villanueva, R; Modesto Alapont, M; Reyes Calzada, S; Santos Durantez, M; Vallés Tarazona, JM, 2007) |
| "As the AIDS epidemic has evolved, so have improvements been made in diagnosis and treatment of Pneumocystis carinii pneumonia, the most common opportunistic infection in AIDS." | 1.28 | Pneumocystis carinii pneumonia: advances in diagnosis and therapy. ( Ettinger, NA, 1990) |
| "In 11 of these a diagnosis of AIDS was confirmed because of an alternative opportunistic infection within 6 months." | 1.28 | Diagnosis, treatment and outcome of pneumonia in the acquired immune deficiency syndrome. ( Collins, JV; Gardner, TD; Gazzard, BG; Griffiths, PD; Hanson, PJ; Youle, M, 1989) |
| "Four cases of pneumocystis carinii pneumonia occurred among 38 renal transplant recipients." | 1.28 | [Pneumocystis carinii pneumonia in renal transplant recipients treated with cyclosporin]. ( Arai, Y; Ishida, A; Kim, CJ; Konishi, T; Kounami, T; Okino, K; Pak, K; Sako, H; Tomoyoshi, T; Wakabayashi, Y, 1989) |
| "An empirical approach to treating Pneumocystis carinii pneumonia was adopted in a prospective study of 73 men with antibodies to human immunodeficiency virus 1 (HIV-1) presenting with respiratory problems." | 1.28 | Empirical treatment without bronchoscopy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. ( Millar, AB; Miller, RF; Semple, SJ; Weller, IV, 1989) |
| "The nocardiosis was cured by a 26-day high-dosage regimen of imipenem and amikacin in combination." | 1.27 | [Successful antibiotic treatment of a pulmonary infection with Nocardia asteroides (biovariety A3)]. ( Egner, E; Jipp, P; Reinold, HM; Ruppert, S; Schaal, KP; Schröter, G, 1988) |
| "Trimethoprim Sulfa is a valuable agent in the prophylaxis of Pneumocystis carinii pneumonia in immunocompromised children." | 1.27 | [Effect of long-term preventive use of TMPS on the composition and resistance behavior of aerobic fecal flora]. ( Allerberger, F; Ausserer, B; Dierich, M; Fink, FM; Guggenbichler, JP, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 16 (51.61) | 18.7374 |
| 1990's | 6 (19.35) | 18.2507 |
| 2000's | 4 (12.90) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Queener, SF | 5 |
| Piper, JR | 1 |
| Johnson, CA | 1 |
| Krauth, CA | 1 |
| Carter, RL | 1 |
| Hosmer, CA | 1 |
| Borotz, SE | 1 |
| Pfefferkorn, ER | 1 |
| Gangjee, A | 1 |
| Adair, OO | 1 |
| Rosowsky, A | 1 |
| Forsch, RA | 1 |
| Sibley, CH | 1 |
| Inderlied, CB | 1 |
| Muramatsu, H | 1 |
| Kuriyama, A | 1 |
| Anzai, Y | 1 |
| Ikegami, T | 1 |
| Chen, Y | 1 |
| Ai, L | 1 |
| Zhou, Y | 1 |
| Zhao, Y | 1 |
| Huang, J | 1 |
| Tang, W | 1 |
| Liang, Y | 1 |
| Majeed, A | 1 |
| Abdullah, HM | 1 |
| Ullah, W | 1 |
| Al Mohajer, M | 1 |
| Liu, J | 1 |
| Bolstad, DB | 1 |
| Bolstad, ES | 1 |
| Wright, DL | 1 |
| Anderson, AC | 1 |
| Bag, S | 1 |
| Tawari, NR | 1 |
| Degani, MS | 1 |
| Keller, MD | 1 |
| Ganesh, J | 1 |
| Heltzer, M | 1 |
| Paessler, M | 1 |
| Bergqvist, AG | 1 |
| Baluarte, HJ | 1 |
| Watkins, D | 1 |
| Rosenblatt, DS | 1 |
| Orange, JS | 1 |
| Martínez Tomás, R | 1 |
| Menéndez Villanueva, R | 1 |
| Reyes Calzada, S | 1 |
| Santos Durantez, M | 1 |
| Vallés Tarazona, JM | 1 |
| Modesto Alapont, M | 1 |
| Gobernado Serrano, M | 1 |
| Tuan, IZ | 1 |
| Dennison, D | 1 |
| Weisdorf, DJ | 1 |
| Holdcroft, CJ | 1 |
| Ellison, RT | 1 |
| Moriuchi, Y | 1 |
| Kamihira, S | 1 |
| Satoh, T | 1 |
| Yanagisako, T | 1 |
| Miyazaki, Y | 1 |
| Nagai, K | 1 |
| Murata, K | 1 |
| Tokunaga, S | 1 |
| Maeda, T | 1 |
| Atogami, S | 1 |
| Ettinger, NA | 1 |
| Hunziker, UA | 1 |
| Nadal, D | 1 |
| Jendis, JB | 1 |
| Tomasik, Z | 1 |
| Wetzel, JC | 1 |
| Schüpbach, J | 1 |
| Seger, RA | 1 |
| Gardner, TD | 1 |
| Youle, M | 1 |
| Hanson, PJ | 1 |
| Griffiths, PD | 1 |
| Collins, JV | 1 |
| Gazzard, BG | 1 |
| Kim, CJ | 1 |
| Pak, K | 1 |
| Wakabayashi, Y | 1 |
| Ishida, A | 1 |
| Arai, Y | 1 |
| Konishi, T | 1 |
| Kounami, T | 1 |
| Tomoyoshi, T | 1 |
| Sako, H | 1 |
| Okino, K | 1 |
| Takabayashi, K | 1 |
| Koike, T | 1 |
| Kurasawa, K | 1 |
| Yamazaki, S | 1 |
| Sugiyama, T | 1 |
| Matsumura, R | 1 |
| Yoshida, H | 1 |
| Tomioka, H | 1 |
| Yoshida, S | 1 |
| Ohshima, H | 1 |
| Papakonstantinou, G | 1 |
| Füessl, H | 1 |
| Matuschke, A | 1 |
| Hehlmann, R | 1 |
| Miller, RF | 1 |
| Millar, AB | 1 |
| Weller, IV | 1 |
| Semple, SJ | 1 |
| Santana, JL | 1 |
| Ramírez-Ronda, CH | 1 |
| Günther, I | 1 |
| Kaben, U | 1 |
| Dunker, H | 1 |
| Brijmohan-Günther, R | 1 |
| Konrad, H | 1 |
| Ruppert, S | 1 |
| Reinold, HM | 1 |
| Jipp, P | 1 |
| Schröter, G | 1 |
| Egner, E | 1 |
| Schaal, KP | 1 |
| Allerberger, F | 1 |
| Guggenbichler, JP | 1 |
| Ausserer, B | 1 |
| Dierich, M | 1 |
| Fink, FM | 1 |
| De Pauw, BE | 1 |
| Novakova, IR | 1 |
| Ubachs, E | 1 |
| Hoes, A | 1 |
| Stalpers, L | 1 |
| Verhagen, C | 1 |
| Deluol, AM | 1 |
| Cenac, J | 1 |
| Michon, C | 1 |
| Matheron, S | 1 |
| Coulaud, JP | 1 |
| Savel, J | 1 |
| Mochizuki, Y | 1 |
| Eeftinck Schattenkerk, JK | 1 |
| Danner, SA | 1 |
| Silvestri, RC | 1 |
| Jensen, WA | 1 |
| Zibrak, JD | 1 |
| Alexander, RC | 1 |
| Rose, RM | 1 |
| Rossi, MR | 1 |
| Banfi, P | 1 |
| Cappuccilli, M | 1 |
| Conter, V | 1 |
| de Poli, D | 1 |
| Piacentini, G | 1 |
| Zurlo, MG | 1 |
| Masera, G | 1 |
2 reviews available for trimethoprim and Opportunistic Infections
| Article | Year |
|---|---|
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Topics: Animals; Drug Design; Humans; Immunosuppression Therapy; Molecular Structure; Opportunistic Infectio | 1995 |
[Refractory respiratory tract infections. 9. Chemotherapy of recent respiratory tract infections. e. Pneumocystis carinii infection].
Topics: Amidines; Drug Combinations; Humans; Opportunistic Infections; Pentamidine; Pneumonia, Pneumocystis; | 1987 |
1 trial available for trimethoprim and Opportunistic Infections
| Article | Year |
|---|---|
Prospective randomized comparison of two prophylactic regimens with trimethoprim-sulfamethoxazole in leukemic children: a two year study.
Topics: Acute Disease; Adolescent; Child; Child, Preschool; Drug Administration Schedule; Drug Combinations; | 1987 |
28 other studies available for trimethoprim and Opportunistic Infections
| Article | Year |
|---|---|
Lipophilic antifolates as agents against opportunistic infections. 1. Agents superior to trimetrexate and piritrexim against Toxoplasma gondii and Pneumocystis carinii in in vitro evaluations.
Topics: Animals; Anti-Infective Agents; Folic Acid Antagonists; Opportunistic Infections; Pneumocystis; Pneu | 1996 |
Synthesis and biological evaluation of 2,4-diamino-6-(arylaminomethyl)pyrido[2,3-d]pyrimidines as inhibitors of Pneumocystis carinii and Toxoplasma gondii dihydrofolate reductase and as antiopportunistic infection and antitumor agents.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cricetinae; Drug | 2003 |
New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.
Topics: AIDS-Related Opportunistic Infections; Animals; Folic Acid Antagonists; Humans; Inhibitory Concentra | 2004 |
A co-infection of varicella-zoster virus and Pneumocystis jirovecii in a non-HIV immunocompromised patient: a case report.
Topics: Acyclovir; Aged, 80 and over; Anti-Infective Agents, Urinary; Antiviral Agents; Coinfection; Fatal O | 2019 |
Rapid and precise diagnosis of pneumonia coinfected by Pneumocystis jirovecii and Aspergillus fumigatus assisted by next-generation sequencing in a patient with systemic lupus erythematosus: a case report.
Topics: Adolescent; Aspergillus fumigatus; Caspofungin; Coinfection; Female; High-Throughput Nucleotide Sequ | 2021 |
First reported case of disseminated Nocardia kroppenstedtii sp nov. infection presenting with brain abscess and endocarditis in an immunocompromised patient with mantle cell lymphoma: challenges in diagnosis and treatment.
Topics: Aged; Anti-Infective Agents; Brain Abscess; Diagnosis, Differential; Drug Combinations; Echocardiogr | 2017 |
Towards new antifolates targeting eukaryotic opportunistic infections.
Topics: Amino Acid Sequence; Animals; Candida glabrata; Drug Design; Folic Acid Antagonists; Fungal Proteins | 2009 |
Synthesis and biological evaluation of biguanide and dihydrotriazine derivatives as potential inhibitors of dihydrofolate reductase of opportunistic microorganisms.
Topics: Animals; Biguanides; Computer Simulation; Drug Design; Folic Acid Antagonists; Liver; Microbial Sens | 2010 |
Severe combined immunodeficiency resulting from mutations in MTHFD1.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Anemia, Megaloblastic; Bone Marrow Examination; Cardiomyopathies; | 2013 |
Pulmonary nocardiosis: risk factors and outcomes.
Topics: Adrenal Cortex Hormones; Adult; Aged; Anti-Infective Agents; Female; Humans; Immunosuppressive Agent | 2007 |
Pneumocystis carinii pneumonitis following bone marrow transplantation.
Topics: Adolescent; Adult; Bone Marrow Transplantation; Child; Drug Combinations; Female; Humans; Infant; Le | 1992 |
Trimethoprim-sulfamethoxazole reaction simulating Pneumocystis carinii pneumonia.
Topics: Diagnosis, Differential; Drug Combinations; HIV Infections; Humans; Hypoxia; Male; Middle Aged; Oppo | 1991 |
[Infection prophylaxis in patients with hematological malignancies (I)--Successful prophylaxis of Pneumocystis carinii pneumonitis with sulfamethoxazole-trimethoprim].
Topics: Administration, Oral; Adult; Aged; Child; Drug Combinations; Hematologic Diseases; Humans; Middle Ag | 1990 |
Pneumocystis carinii pneumonia: advances in diagnosis and therapy.
Topics: Acquired Immunodeficiency Syndrome; Humans; Immunotherapy; Opportunistic Infections; Pentamidine; Pn | 1990 |
Stable human immunodeficiency virus encephalopathy in two infants receiving early intravenous gammaglobulin plus antimicrobial prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Drug Combinations; Drug Therapy, Combination; HI | 1989 |
Diagnosis, treatment and outcome of pneumonia in the acquired immune deficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Biopsy; Bronchoscopy; Cytomegalovirus Infections; Drug Combinati | 1989 |
[Pneumocystis carinii pneumonia in renal transplant recipients treated with cyclosporin].
Topics: Adult; Cyclosporins; Cytomegalovirus Infections; Humans; Kidney Failure, Chronic; Kidney Transplanta | 1989 |
[Pulmonary opportunistic infections in patients with autoimmune diseases].
Topics: Adult; Aged; Autoimmune Diseases; Female; Humans; Isoniazid; Lung Diseases, Fungal; Male; Middle Age | 1989 |
Therapy of pneumocystis carinii pneumonia after trimethoprim-sulfamethoxazole desensitization.
Topics: Acquired Immunodeficiency Syndrome; Adult; Combined Modality Therapy; Desensitization, Immunologic; | 1989 |
Empirical treatment without bronchoscopy for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Bronchoscopy; Drug Combinations; H | 1989 |
[The pregnant woman infected with the human immunodeficiency virus: recommendations for her management].
Topics: Acquired Immunodeficiency Syndrome; Candidiasis; Cytomegalovirus Infections; Female; Humans; Ketocon | 1988 |
Selective decontamination of the digestive tract and fungal infection in acute leukemia patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Digestive System; Drug Administration | 1988 |
[Successful antibiotic treatment of a pulmonary infection with Nocardia asteroides (biovariety A3)].
Topics: Aged; Amikacin; Anti-Bacterial Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinat | 1988 |
[Effect of long-term preventive use of TMPS on the composition and resistance behavior of aerobic fecal flora].
Topics: Adolescent; Bacteria; Child; Child, Preschool; Cross Infection; Dose-Response Relationship, Drug; Dr | 1987 |
Co-trimoxazole in patients with haematological malignancies: a review of 10-years' clinical experience.
Topics: Anti-Infective Agents; Drug Combinations; Humans; Intestines; Leukemia; Neutropenia; Opportunistic I | 1988 |
[11 cases of isosporiasis (Isospora belli) in patients with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Adult; Anti-Infective Agents; Coccidiosis; Cryptosporidiosis; Di | 1988 |
[Pneumocystis carinii pneumonia in patients with AIDS].
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Humans; Male; Middle Aged; Opportunist | 1987 |
Pulmonary infiltrates and hypoxemia in patients with the acquired immunodeficiency syndrome re-exposed to trimethoprim-sulfamethoxazole.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Exudates and Transudates; Humans; Hypo | 1987 |