trimethoprim has been researched along with Neoplasms in 36 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Neoplasms: New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral trimethoprim-sulfamethoxazole (Bactrim) plus erythromycin (TMZ-E) was tested versus placebo (P) as prophylaxis for bacterial infection in a randomized, double-blind trial in adult cancer patients receiving cytotoxic chemotherapy expected to result in significant neutropenia." | 9.05 | Prophylaxis of fever and infection in adult cancer patients. A placebo-controlled trial of oral trimethoprim-sulfamethoxazole plus erythromycin. ( Carr, DJ; Johnson, A; Kramer, BS; Pizzo, PA; Rand, KH; Robichaud, KJ; Yucha, JB, 1984) |
| "Eighty-four cancer patients at risk of infection because of neutropenia were randomized to receive nalidixic acid as an alternative to trimethoprim-sulfamethoxazole (TMP-SMX) for infection prophylaxis." | 5.06 | Selective gut decontamination with nalidixic acid or trimethoprim-sulfamethoxazole for infection prophylaxis in neutropenic cancer patients: relationship of efficacy to antimicrobial spectrum and timing of administration. ( Bow, EJ; Louie, TJ; Rayner, E; Scott, BA, 1987) |
| "In an attempt to reduce the incidence of fever and infection, we randomized patients with cancer to receive trimethoprim/sulfamethoxazole plus erythromycin (TMP/SMX + E) versus placebos after each cycle of chemotherapy (no crossover) and to continue until granulocytopenia (polymorphonuclear leukocytes less than 500/mm3) resolved or the patient became febrile." | 5.05 | Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial. ( Edwards, BK; Johnson, A; Kramer, BS; Pizzo, PA; Robichaud, KJ; Schumaker, C, 1983) |
| "Oral trimethoprim-sulfamethoxazole (Bactrim) plus erythromycin (TMZ-E) was tested versus placebo (P) as prophylaxis for bacterial infection in a randomized, double-blind trial in adult cancer patients receiving cytotoxic chemotherapy expected to result in significant neutropenia." | 5.05 | Prophylaxis of fever and infection in adult cancer patients. A placebo-controlled trial of oral trimethoprim-sulfamethoxazole plus erythromycin. ( Carr, DJ; Johnson, A; Kramer, BS; Pizzo, PA; Rand, KH; Robichaud, KJ; Yucha, JB, 1984) |
| "Ketoconazole or miconazole was randomly administered to 42 and 46 neutropenic patients respectively." | 2.65 | Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients. ( Cruciani, M; Klastersky, J; Meunier-Carpentier, F, 1983) |
| " Initial protocol dosing achieved target plasma levels of trimethoprim (3 to 8 micrograms/ml) or gentamicin (4 to 10 micrograms/ml) in 57 of 68 (84 per cent) C-T/S trials compared to 21 of 60 (35 per cent) C-G trials." | 2.65 | Carbenicillin-trimethoprim/sulfamethoxazole versus carbenicillin-gentamicin as empiric therapy of infection in granulocytopenic patients. A prospective, randomized, double-blind study. ( Braine, HG; Fuller, DJ; Lietman, PS; Saral, R; Stuart, RK, 1980) |
| "One hundred children with cancer and bacterial sepsis were observed for one month after completion of antibiotic treatment for subsequent episodes of infection." | 1.27 | Post-sepsis prophylaxis in cancer patients. ( Hughes, WT; Patterson, G, 1984) |
| "Between 1976 and 1983, 53 cases of Pneumocystis carinii pneumonia were documented at the Mayo Clinic." | 1.27 | Pneumocystis carinii pneumonia. Review of 53 cases. ( Peters, SG; Prakash, UB, 1987) |
| "A total of 229 pediatric cancer patients considered at high risk for getting PCP received prophylaxis, while 19 additonal low-risk cancer patients did not receive sulfamethoxazole-trimethoprim." | 1.26 | Prevention of pneumocystis pneumonia. Use of continuous sulfamethoxazole-trimethroprim therapy. ( Allen, SA; Baehner, RL; Barton, AS; Harris, RE; McCallister, JA, 1980) |
| "Sulfamethoxazole-trimethoprim was administered prophylactically to 786 patients judged to be at sufficient risk for development of Pneumocystis carinii pneumonitis." | 1.26 | Chemoprophylaxis for Pneumocystis carinii pneumonitis: outcome of unstructured delivery. ( Aur, RJ; Feldman, S; Hughes, WT; Malone, WJ; Ryan, M; Wilber, RB, 1980) |
| " Trimethoprim-sulfamethoxazole (TMP-SMX) was used at one of two dosage levels in the treatment of 20 children with PCP and cancer." | 1.25 | Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole. ( Feldman, S; Hughes, WT; Sanyal, SK, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (88.89) | 18.7374 |
| 1990's | 2 (5.56) | 18.2507 |
| 2000's | 1 (2.78) | 29.6817 |
| 2010's | 1 (2.78) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Diamandis, P | 1 |
| Wildenhain, J | 1 |
| Clarke, ID | 1 |
| Sacher, AG | 1 |
| Graham, J | 1 |
| Bellows, DS | 1 |
| Ling, EK | 1 |
| Ward, RJ | 1 |
| Jamieson, LG | 1 |
| Tyers, M | 1 |
| Dirks, PB | 1 |
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 1 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Cieplik, J | 1 |
| Królicki, ZA | 1 |
| Meunier-Carpentier, F | 2 |
| Cruciani, M | 1 |
| Klastersky, J | 3 |
| Hughes, WT | 5 |
| Pizzo, PA | 3 |
| Robichaud, KJ | 2 |
| Edwards, BK | 1 |
| Schumaker, C | 1 |
| Kramer, BS | 2 |
| Johnson, A | 2 |
| Thompson, EI | 1 |
| Callihan, TR | 1 |
| Mauer, AM | 1 |
| Henry, SA | 1 |
| Wolff, LJ | 1 |
| Gualtieri, RJ | 1 |
| Donowitz, GR | 1 |
| Kaiser, DL | 1 |
| Hess, CE | 1 |
| Sande, MA | 1 |
| Carr, DJ | 1 |
| Rand, KH | 1 |
| Yucha, JB | 1 |
| Imoke, E | 1 |
| Dudgeon, DL | 1 |
| Colombani, P | 1 |
| Leventhal, B | 1 |
| Buck, JR | 1 |
| Haller, JA | 1 |
| Patterson, G | 1 |
| Harris, RE | 1 |
| McCallister, JA | 1 |
| Allen, SA | 1 |
| Barton, AS | 1 |
| Baehner, RL | 1 |
| Wilber, RB | 1 |
| Feldman, S | 3 |
| Malone, WJ | 1 |
| Ryan, M | 1 |
| Aur, RJ | 2 |
| Ekert, H | 1 |
| Jurk, IH | 1 |
| Waters, KD | 1 |
| Tiedemann, K | 1 |
| Stuart, RK | 1 |
| Braine, HG | 1 |
| Lietman, PS | 1 |
| Saral, R | 1 |
| Fuller, DJ | 1 |
| Malarme, M | 1 |
| Keating, MJ | 1 |
| Lawson, R | 1 |
| Grose, W | 1 |
| Bodey, GP | 2 |
| Kuhn, S | 1 |
| Chaudhary, S | 1 |
| Verzosa, M | 1 |
| Pratt, C | 1 |
| George, SL | 1 |
| Grose, WE | 1 |
| Rodriguez, V | 1 |
| Sanyal, SK | 1 |
| Hitchings, GH | 1 |
| Ehninger, G | 1 |
| Vallbracht, A | 1 |
| Schüch, K | 1 |
| Kumbier, I | 1 |
| Dopfer, R | 1 |
| Schmidt, H | 1 |
| Ostendorf, P | 1 |
| Gava, R | 1 |
| Carli, M | 1 |
| Pioda, GB | 2 |
| Del Favero, A | 2 |
| Menichetti, F | 2 |
| Spinozzi, F | 1 |
| Gernini, I | 2 |
| Rambotti, P | 2 |
| Davis, RE | 1 |
| Funada, H | 1 |
| Bow, EJ | 1 |
| Rayner, E | 1 |
| Scott, BA | 1 |
| Louie, TJ | 1 |
| Esquembre, C | 1 |
| Ferris, J | 1 |
| Verdeguer, A | 1 |
| Castel, V | 1 |
| Peters, SG | 1 |
| Prakash, UB | 1 |
| Guerciolini, R | 1 |
| Mayer, KH | 1 |
| DeTorres, OH | 1 |
| Israël, L | 1 |
10 reviews available for trimethoprim and Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
Pyrimidines as the chemotherapeutic drugs.
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Drug Design; Humans; Neoplasms; Pipemidic Aci | 1992 |
Prophylaxis in severe granulocytopenia.
Topics: Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Clinical Trials as | 1984 |
Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients.
Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topi | 1984 |
Supportive care for children with cancer. Guidelines of the Childrens Cancer Study Group. Use of prophylactic antibiotics.
Topics: Adolescent; Adult; Amphotericin B; Anti-Bacterial Agents; Bacterial Infections; Candidiasis; Child; | 1984 |
Properties of purine and pyrimidine analogs.
Topics: Animals; Antimetabolites; Antimetabolites, Antineoplastic; Escherichia coli; Folic Acid Antagonists; | 1991 |
[Co-trimoxazole chemoprophylaxis in immunocompromised patients: analysis of the literature].
Topics: Adult; Agranulocytosis; Anti-Infective Agents; Bacterial Infections; Child; Drug Combinations; Human | 1989 |
Clinical chemistry of folic acid.
Topics: Absorption; Aged; Alcoholism; Anemia, Sickle Cell; Anticonvulsants; Arthritis, Rheumatoid; Biologica | 1986 |
[Prophylactic administration of antimicrobiological agents and reflection thereon--prevention of infections in hematologic diseases and malignancies].
Topics: Agranulocytosis; Drug Combinations; Hematologic Diseases; Humans; Infection Control; Neoplasms; Pati | 1986 |
Current guidelines on the use of antibacterial drugs in patients with malignancies.
Topics: Aminoglycosides; Anti-Bacterial Agents; Anti-Infective Agents; Antibody Formation; Bacterial Infecti | 1985 |
11 trials available for trimethoprim and Neoplasms
| Article | Year |
|---|---|
Oral prophylaxis with miconazole or ketoconazole of invasive fungal disease in neutropenic cancer patients.
Topics: Agranulocytosis; Antifungal Agents; Candidiasis; Drug Combinations; Female; Humans; Imidazoles; Keto | 1983 |
Oral antibiotic prophylaxis in patients with cancer: a double-blind randomized placebo-controlled trial.
Topics: Adolescent; Adult; Agranulocytosis; Bacterial Infections; Child; Child, Preschool; Clinical Trials a | 1983 |
Prophylaxis in severe granulocytopenia.
Topics: Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Blood Transfusion; Clinical Trials as | 1984 |
Symposium on infectious complications of neoplastic disease (Part II). Chemoprophylaxis of bacterial infections in granulocytopenic patients.
Topics: Acute Disease; Agranulocytosis; Anti-Bacterial Agents; Bacterial Infections; Clinical Trials as Topi | 1984 |
Double-blind randomized study of prophylactic trimethoprim/sulfamethoxazole in granulocytopenic patients with hematologic malignancies.
Topics: Adolescent; Adult; Aged; Agranulocytosis; Clinical Trials as Topic; Double-Blind Method; Drug Therap | 1983 |
Prophylaxis of fever and infection in adult cancer patients. A placebo-controlled trial of oral trimethoprim-sulfamethoxazole plus erythromycin.
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; D | 1984 |
Prophylactic co-trimoxazole and lactobacilli preparation in neutropenic patients.
Topics: Agranulocytosis; Anti-Bacterial Agents; Antifungal Agents; Bacterial Infections; Biological Products | 1980 |
Carbenicillin-trimethoprim/sulfamethoxazole versus carbenicillin-gentamicin as empiric therapy of infection in granulocytopenic patients. A prospective, randomized, double-blind study.
Topics: Adult; Aged; Agranulocytosis; Bacterial Infections; Carbenicillin; Clinical Trials as Topic; Double- | 1980 |
Vancomycin plus gentamicin and cotrimoxazole for prevention of infections in neutropenic cancer patients (a comparative, placebo-controlled pilot study).
Topics: Adult; Agranulocytosis; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Infections; Clinical | 1981 |
Successful chemoprophylaxis for Pneumocystis carinii pneumonitis.
Topics: Adolescent; Adult; Bacteria; Child; Child, Preschool; Drug Combinations; Drug Evaluation; Female; Fu | 1977 |
Selective gut decontamination with nalidixic acid or trimethoprim-sulfamethoxazole for infection prophylaxis in neutropenic cancer patients: relationship of efficacy to antimicrobial spectrum and timing of administration.
Topics: Agranulocytosis; Antineoplastic Agents; Bacteria; Bacterial Infections; Clinical Trials as Topic; Dr | 1987 |
17 other studies available for trimethoprim and Neoplasms
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutic | 2007 |
Five-year absence of Pneumocystis carinii pneumonitis in a pediatric oncology center.
Topics: Child; Humans; Neoplasms; Pneumonia, Pneumocystis; Sulfamethoxazole; Trimethoprim | 1984 |
Open lung biopsy in the immunocompromised pediatric patient.
Topics: Adolescent; Biopsy; Child; Child, Preschool; Drug Combinations; Female; Humans; Immunosuppression Th | 1983 |
Post-sepsis prophylaxis in cancer patients.
Topics: Antineoplastic Combined Chemotherapy Protocols; Bacterial Infections; Child; Drug Therapy, Combinati | 1984 |
Infectious complications in the child with cancer. III. Prevention.
Topics: Anti-Bacterial Agents; Child; Cross Infection; Filtration; Humans; Immunization; Immunization, Passi | 1981 |
Prevention of pneumocystis pneumonia. Use of continuous sulfamethoxazole-trimethroprim therapy.
Topics: Administration, Oral; Child; Child, Preschool; Drug Combinations; Female; Humans; Immunosuppression | 1980 |
Chemoprophylaxis for Pneumocystis carinii pneumonitis: outcome of unstructured delivery.
Topics: Adolescent; Child; Child, Preschool; Drug Therapy, Combination; Female; Humans; Infant; Male; Neopla | 1980 |
Combination therapy with ticarcillin and sulfamethoxazole-trimethoprim for infections in patients with cancer.
Topics: Bacterial Infections; Drug Therapy, Combination; Female; Fever; Humans; Leukocyte Count; Male; Middl | 1981 |
Sulfamethoxazole-trimethoprim for infections in cancer patients.
Topics: Administration, Oral; Adult; Aged; Bacterial Infections; Drug Synergism; Female; Humans; Male; Middl | 1977 |
Treatment of Pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole.
Topics: Administration, Oral; Adolescent; Amidines; Child; Child, Preschool; Drug Combinations; Drug Evaluat | 1975 |
[Oral prophylaxis of herpes infections using acyclovir following bone marrow transplantation: a clinical and clinico-pharmacological study].
Topics: Acyclovir; Administration, Oral; Adolescent; Adult; Bone Marrow Transplantation; Child; Child, Presc | 1986 |
[Allergy to trimethoprim-sulfamethoxazole in normal, atopic and immunodepressed subjects].
Topics: Anti-Infective Agents; Drug Combinations; Drug Hypersensitivity; Humans; Hypersensitivity, Immediate | 1987 |
Failure of trimethoprim/sulfamethoxazole as prophylactic therapy of gram-negative sepsis in pediatric patients with cancer.
Topics: Bacterial Infections; Child; Drug Combinations; Drug Evaluation; Drug Resistance, Microbial; Gram-Ne | 1986 |
Pneumocystis carinii pneumonia. Review of 53 cases.
Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Drug Combinations; Female; Humans; Leuk | 1987 |
[Immuno-allergic reactions to cotrimoxazole in a hospital population].
Topics: Anti-Infective Agents; Complement Activation; Drug Combinations; Drug Hypersensitivity; Hospitalizat | 1987 |
[Therapeutic use of antibiotic combinations].
Topics: Ampicillin; Anti-Bacterial Agents; Carbenicillin; Chloramphenicol; Colistin; Drug Combinations; Drug | 1971 |
[Infections during antineoplastic drug therapy. Use of the sulfamethoxazole-trimethoprim association].
Topics: Anti-Infective Agents; Antineoplastic Agents; Drug Combinations; Drug Tolerance; Female; Folic Acid | 1972 |