trimethoprim has been researched along with Muscle Spasticity in 2 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Muscle Spasticity: A form of muscle hypertonia associated with upper MOTOR NEURON DISEASE. Resistance to passive stretch of a spastic muscle results in minimal initial resistance (a free interval) followed by an incremental increase in muscle tone. Tone increases in proportion to the velocity of stretch. Spasticity is usually accompanied by HYPERREFLEXIA and variable degrees of MUSCLE WEAKNESS. (From Adams et al., Principles of Neurology, 6th ed, p54)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Results revealed lessened spasticity, improvement in walker-assisted gait, and correlative subjective responses." | 2.66 | Effect of sulfamethoxazole and trimethoprim on neurologic dysfunction in a patient with Joseph's disease. ( Abbott, BP; Mello, KA, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dehen, H | 1 |
| Sangla, S | 1 |
| De Broucker, T | 1 |
| Cheron, F | 1 |
| Cambier, J | 1 |
| Mello, KA | 1 |
| Abbott, BP | 1 |
1 trial available for trimethoprim and Muscle Spasticity
| Article | Year |
|---|---|
Effect of sulfamethoxazole and trimethoprim on neurologic dysfunction in a patient with Joseph's disease.
Topics: Adult; Double-Blind Method; Drug Combinations; Humans; Locomotion; Male; Motor Skills; Muscle Spasti | 1988 |
1 other study available for trimethoprim and Muscle Spasticity
| Article | Year |
|---|---|
[Considerable improvement of spasticity and dystonic phenomena by sulfamethoxazole-trimethoprim in Joseph's disease].
Topics: Adult; Anti-Infective Agents; Drug Combinations; Dystonia; Humans; Male; Muscle Spasticity; Spinocer | 1988 |