trimethoprim has been researched along with Malaria, Falciparum in 15 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study intends to compare the efficacy and tolerability of the combination dihydroartemisinin-piperaquine phosphate-trimethoprim (DPT) versus artemether-lumefantrine (AL) in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal." | 9.15 | Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. ( Faye, B; Faye, O; Kane, D; Kassi, KF; Kiki Barro, CP; Kone, M; Kuete, T; Menan, H; N'diaye, JL; Oga, AS; Same-Ekobo, A; Tine, R; Vicky, AM; Yavo, W, 2011) |
| " This study intends to compare the efficacy and tolerability of the combination dihydroartemisinin-piperaquine phosphate-trimethoprim (DPT) versus artemether-lumefantrine (AL) in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal." | 5.15 | Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. ( Faye, B; Faye, O; Kane, D; Kassi, KF; Kiki Barro, CP; Kone, M; Kuete, T; Menan, H; N'diaye, JL; Oga, AS; Same-Ekobo, A; Tine, R; Vicky, AM; Yavo, W, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (6.67) | 18.2507 |
| 2000's | 9 (60.00) | 29.6817 |
| 2010's | 5 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tarnchompoo, B | 1 |
| Sirichaiwat, C | 1 |
| Phupong, W | 1 |
| Intaraudom, C | 1 |
| Sirawaraporn, W | 1 |
| Kamchonwongpaisan, S | 1 |
| Vanichtanankul, J | 1 |
| Thebtaranonth, Y | 1 |
| Yuthavong, Y | 1 |
| Miller, ME | 1 |
| Parrott, EE | 1 |
| Singh, R | 1 |
| Nelson, SW | 1 |
| Crowther, GJ | 1 |
| Hillesland, HK | 1 |
| Keyloun, KR | 1 |
| Reid, MC | 1 |
| Lafuente-Monasterio, MJ | 1 |
| Ghidelli-Disse, S | 1 |
| Leonard, SE | 1 |
| He, P | 1 |
| Jones, JC | 1 |
| Krahn, MM | 1 |
| Mo, JS | 1 |
| Dasari, KS | 1 |
| Fox, AM | 1 |
| Boesche, M | 1 |
| El Bakkouri, M | 1 |
| Rivas, KL | 1 |
| Leroy, D | 1 |
| Hui, R | 1 |
| Drewes, G | 1 |
| Maly, DJ | 1 |
| Van Voorhis, WC | 1 |
| Ojo, KK | 1 |
| Patel, TS | 1 |
| Bhatt, JD | 1 |
| Dixit, RB | 1 |
| Chudasama, CJ | 1 |
| Patel, BD | 1 |
| Dixit, BC | 1 |
| Hobbs, CV | 1 |
| Neal, J | 1 |
| Conteh, S | 1 |
| Donnelly, L | 1 |
| Chen, J | 1 |
| Marsh, K | 1 |
| Lambert, L | 1 |
| Orr-Gonzalez, S | 1 |
| Hinderer, J | 1 |
| Healy, S | 1 |
| Borkowsky, W | 1 |
| Penzak, SR | 1 |
| Chakravarty, S | 1 |
| Hoffman, SL | 1 |
| Duffy, PE | 1 |
| Menan, H | 1 |
| Faye, O | 1 |
| Same-Ekobo, A | 1 |
| Oga, AS | 1 |
| Faye, B | 1 |
| Kiki Barro, CP | 1 |
| Kuete, T | 1 |
| N'diaye, JL | 1 |
| Vicky, AM | 1 |
| Tine, R | 1 |
| Yavo, W | 1 |
| Kane, D | 1 |
| Kassi, KF | 1 |
| Kone, M | 1 |
| Wilairatana, P | 1 |
| Krudsood, S | 2 |
| Chalermrut, K | 2 |
| Pengruksa, C | 2 |
| Srivilairit, S | 2 |
| Silachamroon, U | 2 |
| Treeprasertsuk, S | 2 |
| Looareesuwan, S | 2 |
| Khalil, I | 1 |
| Rønn, AM | 1 |
| Alifrangis, M | 1 |
| Gabar, HA | 1 |
| Satti, GM | 1 |
| Bygbjerg, IC | 1 |
| Kano, S | 1 |
| Brittenham, GM | 1 |
| Tran, TH | 1 |
| Dolecek, C | 1 |
| Pham, PM | 1 |
| Nguyen, TD | 1 |
| Nguyen, TT | 1 |
| Le, HT | 1 |
| Dong, TH | 1 |
| Tran, TT | 1 |
| Stepniewska, K | 1 |
| White, NJ | 1 |
| Farrar, J | 1 |
| Giao, PT | 1 |
| de Vries, PJ | 1 |
| Hung, le Q | 1 |
| Binh, TQ | 1 |
| Nam, NV | 1 |
| Kager, PA | 1 |
| Nambei, WS | 1 |
| Gbagba, FE | 1 |
| Ndémanga, J | 1 |
| Doui-Doumgba, K | 1 |
| Diallo, TO | 1 |
| Ndadjimbaye, V | 1 |
| Flori, P | 1 |
| Perraut, R | 1 |
| Garraud, O | 1 |
| Parikh, S | 1 |
| Ouedraogo, JB | 1 |
| Goldstein, JA | 1 |
| Rosenthal, PJ | 1 |
| Kroetz, DL | 1 |
| Basco, LK | 1 |
| Le Bras, J | 1 |
| Iyer, JK | 1 |
| Milhous, WK | 1 |
| Cortese, JF | 1 |
| Kublin, JG | 1 |
| Plowe, CV | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Targeted Chemo-elimination (TCE) to Eradicate Malaria in Areas of Suspected or Proven Artemisinin Resistance in Southeast Asia and South Asia[NCT01872702] | 8,000 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| Assessment of Antimalaria Drugs Susceptibility Testing for an Effective Management of Infected Patients in Sub-Sahara Africa[NCT02974348] | Phase 3 | 300 participants (Actual) | Interventional | 2013-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 trials available for trimethoprim and Malaria, Falciparum
| Article | Year |
|---|---|
Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemether; Artemisinins; Cameroon; Child; Child, Prescho | 2011 |
An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Aged; Antimalarials; Artemisinins; Artesunate; Child; Drug Combinations; Drug Res | 2002 |
Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand.
Topics: Adolescent; Adult; Antimalarials; Artemether; Artemisinins; Drug Therapy, Combination; Ethanolamines | 2003 |
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; | 2004 |
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; | 2004 |
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; | 2004 |
Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Child; Child, Preschool; Drug Combinations; | 2004 |
CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Artemisinins; Atovaquone; Drug Combinations; Drug T | 2004 |
Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Central African Republic; Drug Combinations | 2005 |
9 other studies available for trimethoprim and Malaria, Falciparum
| Article | Year |
|---|---|
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
Topics: Animals; Antimalarials; Binding, Competitive; Chlorocebus aethiops; Folic Acid Antagonists; Humans; | 2002 |
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
Topics: Antimalarials; Apicoplasts; Chloroplasts; DNA; DNA-Directed DNA Polymerase; Drug Discovery; Exonucle | 2014 |
Biochemical Screening of Five Protein Kinases from Plasmodium falciparum against 14,000 Cell-Active Compounds.
Topics: Antimalarials; Calcium; Cell Line, Tumor; Hep G2 Cells; Humans; Malaria, Falciparum; Mitogen-Activat | 2016 |
Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway.
Topics: Antimalarials; Humans; Malaria, Falciparum; Molecular Docking Simulation; Molecular Structure; Pheny | 2019 |
HIV treatments reduce malaria liver stage burden in a non-human primate model of malaria infection at clinically relevant concentrations in vivo.
Topics: Animals; Antimalarials; Disease Models, Animal; Drug Combinations; HIV Protease Inhibitors; Liver; L | 2014 |
Dihydrofolate reductase and dihydropteroate synthase genotypes associated with in vitro resistance of Plasmodium falciparum to pyrimethamine, trimethoprim, sulfadoxine, and sulfamethoxazole.
Topics: Adolescent; Adult; Aged; Animals; Antimalarials; Child; Dihydropteroate Synthase; Drug Resistance; G | 2003 |
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa.
Topics: Alkynes; Amodiaquine; Antimalarials; Aryl Hydrocarbon Hydroxylases; Benzoxazines; Burkina Faso; Chro | 2007 |
In vitro sensitivity of Plasmodium falciparum to anti-folinic agents (trimethoprim, pyrimethamine, cycloguanil): a study of 29 African strains.
Topics: Animals; Antimalarials; Confidence Intervals; Drug Resistance; Folic Acid Antagonists; Humans; Letha | 1997 |
Plasmodium falciparum cross-resistance between trimethoprim and pyrimethamine.
Topics: Africa; Alleles; Animals; Antimalarials; Child; Drug Resistance; Genotype; Humans; Malaria, Falcipar | 2001 |