trimethoprim has been researched along with Liver Diseases in 11 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
Liver Diseases: Pathological processes of the LIVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " the half-life t1/2 of their elimination from the plasma; 4." | 5.25 | [Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons]. ( Rieder, VJ; Schwartz, DE, 1975) |
| " The plasma half-life increased moderately with age." | 1.29 | Pharmacokinetics of brodimoprim in special populations. ( Borzio, F; Deroubaix, X; Gaspari, F; Jeanbaptiste, B; Lebacq, E; Lins, R; Pavesio, D; Pelozi, GC; Rosillon, D; Stockis, A, 1993) |
| "Patients with the acquired immunodeficiency syndrome who have PCP have a high trimethoprim-sulfamethoxazole failure rate, due either to adverse reactions or unresponsive infection." | 1.27 | The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. ( Friedland, GH; Harris, CA; Klein, RS; Small, CB, 1985) |
| " the half-life t1/2 of their elimination from the plasma; 4." | 1.25 | [Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons]. ( Rieder, VJ; Schwartz, DE, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kocoshis, SA | 1 |
| Riely, CA | 1 |
| Burrell, M | 1 |
| Gryboski, JD | 1 |
| Lindgren, A | 1 |
| Olsson, R | 1 |
| Stockis, A | 1 |
| Borzio, F | 1 |
| Deroubaix, X | 1 |
| Gaspari, F | 1 |
| Jeanbaptiste, B | 1 |
| Lebacq, E | 1 |
| Lins, R | 1 |
| Pavesio, D | 1 |
| Pelozi, GC | 1 |
| Rosillon, D | 1 |
| Bunch, SE | 1 |
| Pretet, S | 1 |
| Paul, G | 1 |
| Claret, Y | 1 |
| Marin, I | 1 |
| Bagot, M | 1 |
| Dyan, A | 1 |
| Follath, F | 1 |
| Rieder, VJ | 1 |
| Schwartz, DE | 1 |
| Rowland, PH | 1 |
| Center, SA | 1 |
| Dougherty, SA | 1 |
| Muñoz, SJ | 1 |
| Martinez-Hernandez, A | 1 |
| Maddrey, WC | 1 |
| Small, CB | 1 |
| Harris, CA | 1 |
| Friedland, GH | 1 |
| Klein, RS | 1 |
| Goodwin, NM | 1 |
1 review available for trimethoprim and Liver Diseases
| Article | Year |
|---|---|
Hepatotoxicity associated with pharmacologic agents in dogs and cats.
Topics: Animals; Anthelmintics; Benzimidazoles; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; | 1993 |
10 other studies available for trimethoprim and Liver Diseases
| Article | Year |
|---|---|
Cholangitis in a child due to biliary tract anomalies.
Topics: Bile Ducts, Intrahepatic; Celiac Disease; Child, Preschool; Cholangitis; Humans; Klebsiella Infectio | 1980 |
Liver reactions from trimethoprim.
Topics: Adult; Aged; Aged, 80 and over; Alanine Transaminase; Alkaline Phosphatase; Chemical and Drug Induce | 1994 |
Pharmacokinetics of brodimoprim in special populations.
Topics: Adult; Aged; Aged, 80 and over; Aging; Child; Child, Preschool; Dose-Response Relationship, Drug; Fe | 1993 |
[Hepato-pulmonary Nocardia infections (report of one case) (author's transl)].
Topics: Aged; Drug Combinations; Humans; Liver Diseases; Lung Diseases; Male; Middle Aged; Nocardia asteroid | 1979 |
Pharmacokinetics of long half-life antibacterials.
Topics: Anti-Infective Agents; Half-Life; Humans; Kidney Diseases; Kinetics; Liver Diseases; Sulfonamides; T | 1979 |
[Comparison of pharmacokinetics of the combination trimethoprim and sulfamethoxazole in patients with liver diseases and healthy persons].
Topics: Adult; Aged; Body Weight; Drug Combinations; Female; Half-Life; Humans; Liver Diseases; Male; Middle | 1975 |
Presumptive trimethoprim-sulfadiazine-related hepatotoxicosis in a dog.
Topics: Animals; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Drug Combinations; Follow-Up St | 1992 |
Intrahepatic cholestasis and phospholipidosis associated with the use of trimethoprim-sulfamethoxazole.
Topics: Chemical and Drug Induced Liver Injury; Cholestasis, Intrahepatic; Drug Combinations; Female; Humans | 1990 |
The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amidines; Drug Combinations; Drug Therapy, Combination; H | 1985 |
Intravenous bactrim. A preliminary report.
Topics: Adolescent; Adult; Aged; Bacterial Infections; Drug Combinations; Female; Humans; Infant; Injections | 1973 |