trimethoprim has been researched along with Leukocytopenia in 22 studies
Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.
trimethoprim : An aminopyrimidine antibiotic whose structure consists of pyrimidine 2,4-diamine and 1,2,3-trimethoxybenzene moieties linked by a methylene bridge.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We report the hematologic changes in 90 black children who were randomized to receive a 10-day course of either trimethoprim-sulfamethoxazole (TMP-SMZ) or amoxicillin as therapy for acute otitis media." | 9.05 | Similar hematologic changes in children receiving trimethoprim-sulfamethoxazole or amoxicillin for otitis media. ( Doolittle, M; Feldman, S; Hughes, WT; Lott, L; Roberson, P, 1985) |
| " Only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse reactions that included rash, fever, neutropenia, thrombocytopenia, and transaminase elevation." | 7.67 | Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. ( Gordin, FM; Mills, J; Simon, GL; Wofsy, CB, 1984) |
| "We report the hematologic changes in 90 black children who were randomized to receive a 10-day course of either trimethoprim-sulfamethoxazole (TMP-SMZ) or amoxicillin as therapy for acute otitis media." | 5.05 | Similar hematologic changes in children receiving trimethoprim-sulfamethoxazole or amoxicillin for otitis media. ( Doolittle, M; Feldman, S; Hughes, WT; Lott, L; Roberson, P, 1985) |
| "Ninety-four patients receiving immunosuppressive therapy with azathioprine and prednisone after human cadaver kidney transplantation developed urinary tract infections and were treated with co-trimoxazole or another antibiotic in a controlled randomized prospective trial." | 5.04 | Co-trimoxazole and azathioprine: a safe combination. ( Hall, CL, 1974) |
| " Here we describe the occurrence of severe combined immunodeficiency (SCID) with megaloblastic anemia, leukopenia, atypical hemolytic uremic syndrome, and neurologic abnormalities in which hydroxocobalamin and folate therapy provided partial immune reconstitution." | 3.79 | Severe combined immunodeficiency resulting from mutations in MTHFD1. ( Baluarte, HJ; Bergqvist, AG; Ganesh, J; Heltzer, M; Keller, MD; Orange, JS; Paessler, M; Rosenblatt, DS; Watkins, D, 2013) |
| " Only 5 of 37 patients started on trimethoprim-sulfamethoxazole were able to complete treatment; in 29 patients drug toxicity occurred and in 19 treatment was changed due to adverse reactions that included rash, fever, neutropenia, thrombocytopenia, and transaminase elevation." | 3.67 | Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome. ( Gordin, FM; Mills, J; Simon, GL; Wofsy, CB, 1984) |
| "Clinical features of 49 episodes of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome were compared with those of 39 episodes in patients with other immunosuppressive diseases." | 1.27 | Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies. ( Hiemenz, JW; Honig, C; Kovacs, JA; Lane, HC; Longo, DL; Macher, AM; Murray, HW; Shelhamer, J; Stover, D; Urmacher, C, 1984) |
| "12 AIDS/ARC patients with or suspected of Pneumocystis carinii pneumonia were treated with co-trimoxazole and received supplementary folic or folinic acid to avoid peripheral blood cytopenia." | 1.27 | Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia. ( Bygbjerg, IC; Hørding, M; Lund, JT, 1988) |
| "Patients with the acquired immunodeficiency syndrome who have PCP have a high trimethoprim-sulfamethoxazole failure rate, due either to adverse reactions or unresponsive infection." | 1.27 | The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. ( Friedland, GH; Harris, CA; Klein, RS; Small, CB, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 21 (95.45) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (4.55) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keller, MD | 1 |
| Ganesh, J | 1 |
| Heltzer, M | 1 |
| Paessler, M | 1 |
| Bergqvist, AG | 1 |
| Baluarte, HJ | 1 |
| Watkins, D | 1 |
| Rosenblatt, DS | 1 |
| Orange, JS | 1 |
| Gordin, FM | 1 |
| Simon, GL | 1 |
| Wofsy, CB | 1 |
| Mills, J | 1 |
| Kovacs, JA | 1 |
| Hiemenz, JW | 1 |
| Macher, AM | 1 |
| Stover, D | 1 |
| Murray, HW | 1 |
| Shelhamer, J | 1 |
| Lane, HC | 1 |
| Urmacher, C | 1 |
| Honig, C | 1 |
| Longo, DL | 1 |
| Wormser, GP | 1 |
| Krupp, LB | 1 |
| Hanrahan, JP | 1 |
| Gavis, G | 1 |
| Spira, TJ | 1 |
| Cunningham-Rundles, S | 1 |
| Deroń, Z | 1 |
| Jabłkowski, M | 1 |
| Bailey, RR | 1 |
| Bygbjerg, IC | 1 |
| Lund, JT | 1 |
| Hørding, M | 1 |
| Heimpel, H | 1 |
| Raghavachar, A | 1 |
| D'Antonio, RG | 1 |
| Johnson, DB | 1 |
| Winn, RE | 1 |
| van Dellen, AF | 1 |
| Evans, ME | 1 |
| Hollander, H | 1 |
| Small, CB | 1 |
| Harris, CA | 1 |
| Friedland, GH | 1 |
| Klein, RS | 1 |
| Feldman, S | 1 |
| Doolittle, M | 1 |
| Lott, L | 1 |
| Roberson, P | 1 |
| Hughes, WT | 1 |
| Frisch, JM | 1 |
| Kerstan, J | 1 |
| Wolf, H | 1 |
| Herbert, V | 1 |
| Hall, CL | 1 |
| Tosovská, A | 1 |
| Ulrychová, Z | 1 |
| Veen, MR | 1 |
| Maier, C | 1 |
| Heer, HR | 1 |
| Gaylarde, PM | 1 |
| Sarkany, I | 1 |
| Destaing, F | 1 |
| Villand, J | 1 |
| Carli, H | 1 |
| Carli, PM | 1 |
| Martin, F | 1 |
| Klepping, C | 1 |
| Wegmüller, E | 1 |
2 reviews available for trimethoprim and Leukocytopenia
| Article | Year |
|---|---|
Hematological side effects of co-trimoxazole.
Topics: Anemia; Anti-Infective Agents; Blood Cells; Drug Combinations; Humans; Leukopenia; Risk; Sulfamethox | 1987 |
Trimethoprim-sulfamethoxazole. Metabolism of folic acid in man.
Topics: Agranulocytosis; Aminobenzoates; Anemia; Bile; Biological Transport, Active; Bone Marrow; Bone Marro | 1973 |
2 trials available for trimethoprim and Leukocytopenia
| Article | Year |
|---|---|
Similar hematologic changes in children receiving trimethoprim-sulfamethoxazole or amoxicillin for otitis media.
Topics: Amoxicillin; Clinical Trials as Topic; Drug Combinations; Female; Humans; Infant; Leukocyte Count; L | 1985 |
Co-trimoxazole and azathioprine: a safe combination.
Topics: Administration, Oral; Azathioprine; Cadaver; Clinical Trials as Topic; Drug Therapy, Combination; Hu | 1974 |
18 other studies available for trimethoprim and Leukocytopenia
| Article | Year |
|---|---|
Severe combined immunodeficiency resulting from mutations in MTHFD1.
Topics: 3-Hydroxyacyl CoA Dehydrogenases; Anemia, Megaloblastic; Bone Marrow Examination; Cardiomyopathies; | 2013 |
Adverse reactions to trimethoprim-sulfamethoxazole in patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Drug Combinations; Drug Eruptions; Drug Hypersensitivity; | 1984 |
Pneumocystis carinii pneumonia: a comparison between patients with the acquired immunodeficiency syndrome and patients with other immunodeficiencies.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Aged; Child; Drug Combinations; Drug Eruption | 1984 |
Acquired immunodeficiency syndrome in male prisoners. New insights into an emerging syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Candida albicans; Drug-Related Side Effects and Adverse R | 1983 |
[Side effects of toxoplasmosis treatment].
Topics: Adolescent; Adult; Anemia; Antiprotozoal Agents; Child; Child, Preschool; Drug Eruptions; Dyspepsia; | 1980 |
Leukopenia due to a trimethoprim-azathioprine interaction.
Topics: Azathioprine; Drug Interactions; Humans; Leukopenia; Male; Middle Aged; Trimethoprim | 1984 |
Effect of folic and folinic acid on cytopenia occurring during co-trimoxazole treatment of Pneumocystis carinii pneumonia.
Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Complex; Anemia; Drug Combinations; Folic Acid; Hem | 1988 |
Effect of folinic acid on the capacity of trimethoprim-sulfamethoxazole to prevent and treat Pneumocystis carinii pneumonia in rats.
Topics: Animals; Dexamethasone; Drug Combinations; Drug Interactions; Immunosuppression Therapy; Leucovorin; | 1986 |
Leukopenia, trimethoprim-sulfamethoxazole, and folinic acid.
Topics: Acquired Immunodeficiency Syndrome; Drug Combinations; Humans; Leucovorin; Leukopenia; Sulfamethoxaz | 1985 |
The treatment of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Amidines; Drug Combinations; Drug Therapy, Combination; H | 1985 |
Clinical experience with adverse reactions to trimethoprim-sulfamethoxazole.
Topics: Aged; Agranulocytosis; Anemia, Aplastic; Anemia, Macrocytic; Child; Depression; Drug Combinations; D | 1973 |
[Therapeutic experience with trimethoprim and sulfamethoxazole in infections of infancy and childhood].
Topics: Adolescent; Anti-Infective Agents; Bacterial Infections; Bronchitis; Child; Child, Preschool; Drug S | 1972 |
[Our experience with Septrin in the therapy of urinary tract infections in chldren].
Topics: Adolescent; Anti-Infective Agents; Child; Child, Preschool; Drug Combinations; Evaluation Studies as | 1973 |
[Side effects of trimethoprim-sulfamethoxazole (co-trimoxazole)].
Topics: Adult; Aged; Crystallization; Humans; Leukopenia; Male; Sulfamethoxazole; Thrombocytopenia; Trimetho | 1973 |
[Studies on the hematologic tolerance of Bactrim].
Topics: Anti-Infective Agents; Erythrocytes; Folic Acid Antagonists; Folic Acid Deficiency; Hematologic Dise | 1972 |
Suppression of thymidine uptake of human lymphocytes by co-trimoxazole.
Topics: Anti-Infective Agents; Culture Techniques; Depression, Chemical; Drug Combinations; Drug Synergism; | 1972 |
[Transient agranulocytosis in the course of treatment with sulfamethoxazole-trimethoprim].
Topics: Adolescent; Adult; Aged; Agranulocytosis; Anemia, Hemolytic; Anti-Infective Agents; Bone Marrow; Bon | 1972 |
[Treatment of chronically recurring urinary tract infection with trimethoprim sulfamethoxazole (Eusaprim)].
Topics: Adult; Aged; Anti-Infective Agents; Chronic Disease; Female; Folic Acid Antagonists; Gastrointestina | 1970 |